Bachmann, CH
Adrian Bachmann, Renens CH
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20090128824 | OPTICAL IMAGING SYSTEM WITH EXTENDED DEPTH OF FOCUS - The invention concerns an optical imaging apparatus comprising (o) a light source ( | 05-21-2009 |
20100141956 | DUAL BEAM HETERODYNE FOURIER DOMAIN OPTICAL COHERENCE TOMOGRAPHY - The present invention relates to an apparatus and a method combining achromatic complex FDOCT signal reconstruction with a common path and dual beam configuration. The complex signal reconstruction allows resolving the complex ambiguity of the Fourier transform and to enhance the achievable depth range by a factor of two. The dual beam configuration shares the property of high phase stability with common path FDOCT. This is of importance for a proper complex signal reconstruction and is in particular useful in combination with handheld probes such as in endoscopy and catheter applications. The advantages of the present invention are in particular the flexibility to choose arbitrarily positioned interfaces in the sample arm as reference together with the possibility to compensate for dispersion. | 06-10-2010 |
Adrian Bachmann, Tobel CH
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20090015842 | Phase Sensitive Fourier Domain Optical Coherence Tomography - Optical Coherence Tomography (OCT) is an imaging technique with high axial resolution in the micro-meter-scale range combined with a high sensitivity allowing for example to probe weakly back-scattering structures beneath the surface of biological tissues up to several millimeters. A major improvement of this conventional technique represents Fourier Domain OCT with a further decrease in image acquisition time and additional sensitivity. The apparatus including appropriate signal processing reconstructs the depth profile from the spectrally resolved light signal generated by a broadband source and an interferometric imaging system. By frequency shifting the light fields with frequency shifting means in the reference and sample arm a phase resolved signal at high speed can be registered. Therefore the reference arm does not rely on arm length changes or delays. The beating signal generated in this way shows high phase stability. The phase of this beating signal is not wavelength dependent, as the frequency shift applied is the same for all wavelengths. Moreover this results in an additional suppression of unwanted auto-correlated distortion as well as an extended depth range. | 01-15-2009 |
Christian Gottlieb Bachmann, Ellikon An Der Thur CH
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20080251127 | Reflux divider for a column having portions for the transfer of material arranged in parallel - The reflux divider for a separation column has portions for the transfer of material arranged in parallel which are mutually bounded by a vertical dividing wall and which include members for the controlled dividing of a liquid to be treated. A reflux divider feeds part flows to the respective portions employing connection lines that are feed from a common container. A restrictor valve is used in one connection line to control the flow based on signals from a pair of flow meters. | 10-16-2008 |
20090321362 | SYSTEM FOR GENERATING A DISCRETE LIQUID PHASE IN A CONTINUOUS LIQUID PHASE - The device ( | 12-31-2009 |
20100237518 | Liquid distributor - The liquid distributor includes a channel for the reception of a liquid which is divided by a dividing wall into a first chamber and a second chamber. An inlet element for a liquid opens into the first chamber to fill the first chamber with the liquid. Openings are provided in the dividing wall so that the liquid can be distributed from the first chamber via the openings into the second chamber in the form of jets to create turbulent vortices. | 09-23-2010 |
Christof Bachmann, Sennwald CH
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20150308584 | VALVE - A valve with an opening surrounded by a seat, and a closure member, which, in a closed position, presses onto the seat and closes the opening and, in an intermediate position, is raised from the seat and overlaps with the opening and, in a maximum opening position, at least partially releases the opening. The valve has a frst valve drive for moving the closure member between the maximum opening position and the intermediate position along a first movement track, and a second valve drive for moving the closure member between the intermediate position and the closed position along a second movement track which is at an angle to the first movement track. The valve has at least one transmission part which is provided for reversible deformation by the second valve drive, and the first valve drive acts on the closure member with the interposition of the transmission part. | 10-29-2015 |
Christoph Bachmann, Sennwald CH
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20150136236 | METHOD OF OPERATING A VALVE - Method of operating a valve ( | 05-21-2015 |
Felix Bachmann, Basel CH
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20080221171 | Phenylaminopyridines - The invention relates to novel substituted 3-phenylamino-5-(3-aminophenyl)pyridines and corresponding pyrazines of formula (I), wherein A is CH, C-lower alkyl or N, R | 09-11-2008 |
20080287681 | Substituted Benzimidazoles and their Use for Inducing Apoptosis - The invention relates to compounds of formula (I) | 11-20-2008 |
20120264792 | FURAZANOBENZIMIDAZOLES AS PRODRUGS TO TREAT NEOPLASTIC OR AUTOIMMUNE DISEASES - A compound of formula (II) | 10-18-2012 |
20130345263 | USE OF STATHMIN AS A BIOMARKER OF DRUG RESPONSE TO FURAZANOBENZIMIDAZOLES - Use of stathmin as a biomarker for predicting the response, such as resistance, to a compound, wherein the compound is a furazanobenzimidazole compound of general formula (I). | 12-26-2013 |
20140005237 | USE OF ACETYLATED TUBULIN AS A BIOMARKER OF DRUG RESPONSE TO FURAZANOBENZIMIDAZOLES | 01-02-2014 |
20140024686 | USE OF GLU-TUBULIN AS A BIOMARKER OF DRUG RESPONSE TO FURAZANOBENZIMIDAZOLES - Use of glu-tubulin as a biomarker for predicting the response to a compound, preferably resistance of a disease such as cancer in a subject to said compound, wherein the compound is a furazanobenzimidazole compound of general formula (I). | 01-23-2014 |
20140045897 | USE OF BUBR1 AS A BIOMARKER OF DRUG RESPONSE TO FURAZANOBENZIMIDAZOLES - Use of BUBR1 as a biomarker for predicting the response to a compound, preferably resistance of a disease such as cancer in a subject, wherein the compound is a furazanobenzimidazole compound of general formula (I). | 02-13-2014 |
20140080872 | USE OF PHOSPHO-AKT AS A BIOMARKER OF DRUG RESPONSE - Use of phospho-Akt as a biomarker for predicting the response, such as resistance, to a compound, wherein phospho-Akt is Akt that has been phosphorylated on one or more residues, with the proviso that for Akt1, Akt2, and Akt3 the designation phospho-Akt is used to indicate phosphorylation at a site other than T308, T309 or T305 respectively, wherein the compound is a compound of general formula (I) wherein R represents phenyl, thienyl or pyridinyl wherein phenyl is optionally substituted by one or two substituents independently selected from alkyl, halo-lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, acyloxy-lower alkyl, phenyl, hydroxy, lower alkoxy, hydroxy-lower alkoxy, lower alkoxy-lower alkoxy, phenyl-lower alkoxy, lower alkylcarbonyloxy, amino, monoalkylamino, dialkylamino, lower alkoxycarbonylamino, lower alkylcarbonylamino, substituted amino wherein the two substituents on nitrogen form together with the nitrogen heterocyclyl, lower alkylcarbonyl, carboxy, lower alkoxycarbonyl, cyano, halogen, and nitro; and wherein two adjacent substituents are methylenedioxy; and wherein pyridinyl is optionally substituted by lower alkoxy, amino or halogen; X represents a group C═Y, wherein Y stands for oxygen or nitrogen substituted by hydroxy or lower alkoxy; R | 03-20-2014 |
Hans-Rudolf Bachmann, Buttikon CH
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20090320617 | Device and Method for the Adjustment of a Temperature of a Liquid - A device and a method for the adjustment of a temperature of a liquid which is contained in one or more sample vessels are specified, a control unit and a temperature adjustment unit being provided, which acts on the liquid contained in the sample vessels. Furthermore, the control unit is operatively connected to the temperature adjustment unit. The liquid to be analyzed contains absorption elements in order to accelerate the temperature adjustment in the liquid to be analyzed. | 12-31-2009 |
20100114507 | METHOD FOR GRAVIMETRIC VOLUME DETERMINATION - A method of gravimetric volume determination is described in which a load cell can be calibrated either outside of an analytic analyzer for gravimetric calibration of said analyzer, or in a fully automated manner inside said analyzer. | 05-06-2010 |
20100137574 | SYSTEM AND METHOD FOR THE AUTOMATED EXTRACTION OF NUCLEIC ACIDS - A system and method for the automated extraction of nucleic acids from nucleic acids containing samples are disclosed. In the system, reagents provided in cavities of a reagent plate are transferred to samples accommodated in a process plate using a pipetting device comprising pipettes provided with disposable pipette tips for pipetting of the reagents to obtain sample-reagent mixtures, the sample-reagent mixtures accommodated in the process plate are incubated by an incubating device to release the nucleic acids; the released nucleic acids accommodated in the process plate are separated by a separating device and released to obtain extracted nucleic acids containing fluids; the extracted nucleic acids containing fluids are transferred to cavities of an output plate by disposable pipette tips; wherein each of the samples is assigned one-to-one to a cavity of the reagent plate, at least one of the disposable pipette tips and a cavity of the output plate. | 06-03-2010 |
Heinrich Bachmann, Wintersingen CH
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20110038960 | PREPARATION AND USE OF A PLANT EXTRACT FROM SOLANUM GLAUCOPHYLLUM WITH AN ENRICHED CONTENT OF 1,25-DIHYDROXYVITAMIN D3 GLYCOSIDES AND QUERCETIN GLYCOSIDES - The present invention relates to the preparation of an enriched and equilibrated plant extract from | 02-17-2011 |
20120288573 | USE OF EXTRACTS FROM SALONUM GLAUCOPHYLLUM FOR TREATING BONE METABOLISM DISORDERS AND KIDNEY DISORDERS - A method is provided for preventing or treating bone or musculoskeletal metabolism disorders or kidney malfunction in humans. It comprises providing to a subject in need of that a calcium containing or calcium enriched diet combined with the administration of an efficient amount of a plant extract of | 11-15-2012 |
20120301513 | COMPOSITION COMPRISING SOLANUM GLAUCOPHYLLUM FOR PREVENTING AND/OR TREATING HYPOCALCAEMIA AND FOR STABILIZING BLOOD CALCIUM LEVELS - The present invention provides a pharmaceutical and/or veterinary composition comprising a retard release formulation of a | 11-29-2012 |
20130280351 | PREPARATION AND USE OF A PLANT EXTRACT FROM SOLANUM GLAUCOPHYLLUM WITH AN ENRICHED CONTENT OF 1,25 DIHDROCYVITAMIN D3 GLYCOSIDES AND QUERCETIN GLYCOSIDES - The present invention relates to the preparation of an enriched and equilibrated plant extract from | 10-24-2013 |
20140322322 | COMPOSITION COMPRISING SOLANUM GLAUCOPHYLLUM FOR PREVENTING AND/OR TREATING HYPOCALCAEMIA AND FOR STABILIZING BLOOD CALCIUM LEVELS - The present invention provides a pharmaceutical and/or veterinary composition comprising a retard release formulation of a | 10-30-2014 |
Herbert Bachmann, Luzern CH
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20110172932 | METHOD AND DEVICE FOR DETERMINING THE REPLACEMENT STATE OF WEAR OF A SUPPORT MEANS OF AN ELEVATOR - A method for determining the degree service life end of a support cable of an elevator, wherein the support cable is routed over a drive sheave and/or one or more return pulleys and connects a car to a counterweight, includes the steps of: the support cable is subdivided into a plurality of sections; and for each of the sections, a determination is made as to whether the section passes over the drive sheave and/or one or more of the return pulleys during a trip, and if this is the case, a usage level representing the degree of service life use is increased accordingly. | 07-14-2011 |
Jeanne-Pierre Bachmann, Wadenswil CH
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20110263725 | Alpha-branched Alkenoic Acids and the Use of Alpha-branched Alkanoic and Alkenoic Acids as a Fragrance - The present invention refers to alpha branched alkanoic and alkenoic acids of formula (I) | 10-27-2011 |
Jean-Pierre Bachmann, Wadenswil CH
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20080200554 | Cycloaklyldiene-(Ortho Substituted Phenyl)-Acetonitriles and Their Use as Odorants - Compounds of formula (I) and their use as fragrance ingredients | 08-21-2008 |
20080269102 | 3-(2-Alkoxycarbonyloxy-Phenyl) Acrylic Acid Esters And Their Use As Precursors For The Delivery Of Olfactory Compounds - A compound of formula (I), their use as precursors and a method of their production | 10-30-2008 |
20080305066 | 2-C-Substituted Propane-1,3-Dicarbonyl Compounds and Their Use in Neutralising Malodour - Use of a compound of formula 1 as malodour neutraliser | 12-11-2008 |
20080306170 | Organic Compounds - The use of 2-phenyl-2-alkene nitriles as fragrance ingredients and fragrance applications comprising them. These fragrance applications can be e.g. perfumes, household products, laundry products, body care products and cosmetics. | 12-11-2008 |
20090036690 | ORGANIC COMPOUNDS - The use of indole carbamates as fragrance ingredients and fragrance applications comprising indole carbamates in an effective amount. | 02-05-2009 |
20100137627 | 3-(2-Alkoxycarbonyloxy-Phenyl) Acrylic Acid Esters and Their Use as Precursors for the Delivery of Olfactory Compounds - A compound of formula (I), their use as precursors and a method of their production | 06-03-2010 |
20140107006 | Organic Compounds - Disclosed are certain compounds according to the general formula (I) | 04-17-2014 |
20150299614 | IMPROVEMENTS IN OR RELATING TO ORGANIC COMPOUNDS - A fragrance oil comprising a compound of formula (I) | 10-22-2015 |
Joerg Bachmann, Buerglen/tg CH
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20150027355 | GRATE STEP MODULE FOR A THRUST COMBUSTION GRATE - A grate step module ( | 01-29-2015 |
Julien Bachmann, Cugy CH
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20120110429 | PLATFORM ENABLING WEB-BASED INTERPERSONAL COMMUNICATION WITHIN SHARED DIGITAL MEDIA - The invention consists of a new form of digital media document comprising content, applications and services that facilitate sharing and social expression on the Internet within a unified media object instead of being confined to specific websites such as social-networking services. This invention transforms content into content which is reusable, particularly for social expression, by enabling encapsulation of said content within an online document. This can be achieved by presenting a set of library applications to the user, where each application connects to a specific third-party web service, and presents the third-party service reusable content to the user, so the user can reuse in a very simple way, such as drag-and-drop. The invention promotes social engagement with digital multimedia while enabling social expression, commenting and editing of content or of the online document and optionally linking these activities to the website or service timeline. | 05-03-2012 |
Marco Bachmann, Burglen Tg CH
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20110259252 | Cladding Element for Device Sections of Incinerators - A cladding element for device sections of incinerators consists of a lower plate ( | 10-27-2011 |
Martin Bachmann, Seuzach CH
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20090175896 | CAT Allergen Conjugates and Uses Thereof - The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions comprising a virus-like particle (VLP) or a virus particle and at least one antigen, particularly at least one feline antigen, and more particularly at least one feline antigen that is a human allergen. In certain embodiments, the antigen is a Fel d1 antigen or a fragment thereof, covalently linked to the VLP. The invention also provides methods for producing the compositions. The compositions of the invention induce efficient immune responses, in particular antibody responses, in mammals, particularly humans. The compositions and methods of the invention are useful in the production of vaccines, in particular for the treatment and/or prevention of allergies to cat dander and other cat antigens and allergens. | 07-09-2009 |
20100119540 | Vaccination Regimen for B-Cell Vaccines - This invention relates to the field of vaccination and treatment or prevention diseases. In particular this invention relates to the treatment or prevention of diseases by inducing hapten-specific antibody responses in a vaccinated subject. The invention further provides a method for prevention or treatment of a disease by inducing hapten-specific antibodies in a subject comprising administering into said subject a composition comprising a virus-like particle of an RNA bacteriophage and at least one hapten linked thereto. | 05-13-2010 |
20110027220 | Interleukin-1 Conjugates and Uses Thereof - The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen array, wherein the antigen is an IL-1 protein, an IL-1 mutein or an IL-1 fragment. More specifically, the invention provides a composition comprising a virus-like particle, and at least one IL-1 protein, IL-1 mutein or at least one IL-1 fragment linked thereto. The invention also provides a process for producing the composition. The compositions of the invention are useful in the production of vaccines for the treatment of inflammatory diseases, and chronic autoimmune diseases, genetic diseases and cardiovascular diseases. The composition of the invention efficiently induces immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context. | 02-03-2011 |
20110045013 | CAT Allergen Conjugates and Uses Thereof - The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions comprising a virus-like particle (VLP) or a virus particle and at least one antigen, particularly at least one feline antigen, and more particularly at least one feline antigen that is a human allergen. In certain embodiments, the antigen is a Fel d1 antigen or a fragment thereof, covalently linked to the VLP. The invention also provides methods for producing the compositions. The compositions of the invention induce efficient immune responses, in particular antibody responses, in mammals, particularly humans. The compositions and methods of the invention are useful in the production of vaccines, in particular for the treatment and/or prevention of allergies to cat dander and other cat antigens and allergens. | 02-24-2011 |
20110081371 | Angiotensin peptide-carrier conjugates and uses thereof - The present invention provides conjugates of peptide derivatives of the mammalian peptide hormones angiotensinogen, angiotensin I and angiotensin II, presented in a repetitive scaffold by coupling the peptide derivatives to a carrier, particularly a virus-like particle (VLP). The invention also provides methods of producing such conjugates, and immunotherapeutic uses of the resulting immunogen conjugates for the therapy and prophylaxis of conditions associated with the renin-activated angiotensin system. | 04-07-2011 |
20110123541 | Human Monoclonal Nicotine Specific Antibodies - The invention relates to recombinantly produced human monoclonalantibodies which are specifically binding nicotine and to nucleic acids encoding the same. The invention further relates to the use of such antibodies in the treatment of nicotine addiction. | 05-26-2011 |
20110212122 | Nerve Growth Factor Conjugates and Uses Thereof - The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides composition comprising a virus-like particle (VLP) linked to at least one antigen, wherein said antigen is NGF antigen. The invention also provides a process for producing the composition. The compositions of this invention are useful in the production of vaccines, in particular, for the treatment of pain. Moreover, the compositions of the invention induce efficient immune responses, in particular antibody responses. | 09-01-2011 |
20110262472 | VACCINE COMPOSITIONS FOR THE TREATMENT OF DENGUE FEVER AND USES THEREOF - The invention provides compositions, vaccine compositions and pharmaceutical compositions for the treatment, amelioration and/or prevention of dengue fever. The compositions, vaccine compositions and pharmaceutical compositions of the invention comprise a virus-like particle of an RNA bacteriophage and at least one antigen, wherein said at least one antigen is a dengue antigen. When administered to an animal, preferably to a human, said compositions, vaccine compositions and pharmaceutical compositions induce efficient immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against dengue virus, preferably against dengue virus of any one of serotypes 1 to 4. Thus, the invention further provides methods of treating, ameliorating and/or preventing dengue virus infection by way of active immunization against domain III of the dengue virus envelope protein E, or against antigenic fragments thereof. | 10-27-2011 |
20110318300 | User of Interleukin-1 Conjugates in the Treatment of Diabetes - The invention provides compositions, pharmaceutical compositions and vaccines for the treatment, amelioration and/or prophylaxis of diabetes, preferably of type II diabetes. The compositions, pharmaceutical compositions and vaccines of the invention comprise a core particle and an antigen, wherein said antigen comprises an interleukin-1 (IL-1) molecule. When administered to an animal, preferably to a human, said compositions, pharmaceutical compositions, and vaccines induce efficient immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against IL-1. Thus, the invention provides methods of treating, ameliorating or preventing diabetes, preferably type II diabetes, by way of active immunization against IL-1. | 12-29-2011 |
20120114674 | Molecular Antigen Array - The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses. | 05-10-2012 |
20130344098 | CAT Allergen Conjugates and Uses Thereof - The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions comprising a virus-like particle (VLP) or a virus particle and at least one antigen, particularly at least one feline antigen, and more particularly at least one feline antigen that is a human allergen. In certain embodiments, the antigen is a Fel d1 antigen or a fragment thereof, covalently linked to the VLP. The invention also provides methods for producing the compositions. The compositions of the invention induce efficient immune responses, in particular antibody responses, in mammals, particularly humans. The compositions and methods of the invention are useful in the production of vaccines, in particular for the treatment and/or prevention of allergies to cat dander and other cat antigens and allergens. | 12-26-2013 |
Martin Bachmann, Winterthur CH
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20080274131 | Molecular antigen arrary - The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses. | 11-06-2008 |
20110305723 | Molecular Antigen Array - The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses. | 12-15-2011 |
20120301499 | Packaging of Immunostimulatory Substances into Virus-Like Particles: Method of Preparation and Use - The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs). Such CpG-VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against both the VLPs and antigens are especially directed to the Th1 type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases. | 11-29-2012 |
20130315949 | Molecular Antigen Array - The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses. | 11-28-2013 |
20150202281 | Molecular Antigen Array - The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses. | 07-23-2015 |
Martin Bachmann, Ramismuhle CH
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20120263743 | INFLUENZA HEMAGGLUTININ COMPOSITIONS AND USES THEREOF - The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions, vaccine compositions and pharmaceutical compositions for the treatment, amelioration and/or prevention of influenza. The compositions, vaccine compositions and pharmaceutical compositions of the invention comprise a virus-like particle of an RNA bacteriophage and at least one antigen, wherein said at least one antigen is an ectodomain of an influenza virus hemagglutinin protein or a fragment of said ectodomain of an influenza virus hemagglutinin protein. When administered to an animal, preferably to a human, said compositions, vaccine compositions and pharmaceutical compositions efficiently induce immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against influenza virus. Thus, the invention further provides methods of treating, ameliorating and/or preventing influenza virus infection. | 10-18-2012 |
20130230484 | Interleukin-1 Conjugates and Uses Thereof - The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen array, wherein the antigen is an IL-1 protein, an IL-1 mutein or an IL-1 fragment. More specifically, the invention provides a composition comprising a virus-like particle, and at least one IL-1 protein, IL-1 mutein or at least one IL-1 fragment linked thereto. The invention also provides a process for producing the composition. The compositions of the invention are useful in the production of vaccines for the treatment of inflammatory diseases, and chronic autoimmune diseases, genetic diseases and cardiovascular diseases. The composition of the invention efficiently induces immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context. | 09-05-2013 |
Martin F. Bachmann, Ramismuhle CH
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20130109845 | FULLY HUMAN INFLUENZA M2 SPECIFIC ANTIBODIES | 05-02-2013 |
20130115189 | Use of Interleukin-1 Beta Mutein Conjugates in the Treatment of Diabetes - The present invention provides compositions, pharmaceutical compositions and vaccines for the treatment, amelioration and/or prophylaxis of type II diabetes. The compositions, pharmaceutical compositions and vaccines of the invention comprise a virus-like particle of an RNA bacteriophage and an antigen, wherein said antigen comprises an interleukin-1 beta (IL-1β) mutein. When administered to an animal, preferably to a human, said compositions, pharmaceutical compositions, and vaccines induce efficient immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against IL-1β. Thus, the invention provides methods of treating, ameliorating or preventing type II diabetes by way of active immunization against IL-1β. | 05-09-2013 |
20130142821 | Hapten-Carrier Conjugates and Uses Thereof - The present invention provides compositions comprising a conjugate of a hapten with a carrier in an ordered and repetitive array, and methods of making such compositions. The conjugates and compositions of the invention may comprise a variety of haptens, including hormones, toxins and drugs, especially drugs of addiction such as nicotine. Compositions and conjugates of the invention are useful for inducing immune responses against haptens, which can use useful in a variety of therapeutic, prophylactic and diagnostic regimens. In certain embodiments, immune responses generated using the conjugates, compositions and methods of the present invention are useful to prevent or treat addiction to drugs of abuse and the resultant diseases associated with drug addiction. | 06-06-2013 |
20140141036 | In Vivo Activation of Antigen Presenting Cells for Enhancement of Immune Responses Induced by Virus Like Particles - The invention relates to the finding that stimulation of antigen presenting cell (APC) activation using substances such as anti-CD40 antibodies or DNA oligomers rich in non-methylated C and G (CpGs) can dramatically enhance the specific T cell response obtained after vaccination with recombinant virus like particles (VLPs) coupled, fused or otherwise attached to antigens. While vaccination with recombinant VLPs fused to a cytotoxic T cell (CTL) epitope of lymphocytic choriomeningitis virus induced low levels cytolytic activity only and did not induce efficient anti-viral protection, VLPs injected together with anti-CD40 antibodies or CpGs induced strong CTL activity and full anti-viral protection. Thus, stimulation of APC-activation through antigen presenting cell activators such as anti-CD40 antibodies or CpGs can exhibit a potent adjuvant effect for vaccination with VLPs coupled, fused or attached otherwise to antigens. | 05-22-2014 |
Martin F. Bachmann, Winterthur CH
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20110268740 | FULLY HUMAN INFLUENZA M2 SPECIFIC ANTIBODIES - The present invention relates to human antibodies, preferably to fully human antibodies, which are specifically binding to influenza M2e antigen. The invention further relates to individual light- and/or heavy chains of such antibodies, to nucleic acids encoding said antibodies or their light- and/or heavy chain, and to expression vectors for the expression of said anti-bodies. Furthermore, the invention relates to the use of said antibodies in the treatment and/or prevention of influenza A virus infection, preferably in humans. | 11-03-2011 |
20150030620 | PACKAGING OF IMMUNOSTIMULATORY SUBSTANCES INTO VIRUS-LIKE PARTICLES: METHOD OF PREPARATION AND USE - The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs). Such CpG-VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against both the VLPs and antigens are especially directed to the Th1 type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases. | 01-29-2015 |
Michael Bachmann, Butschwil CH
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20150074927 | FLOOR MAINTENANCE TOOL WITH MOP RELEASE MECHANISM - A floor maintenance too! including a handle and a tool coupled to the handle. The tool head includes a frame that supports a first engagement panel and a second engagement panel, with each panel disposed on an underside of the frame. The tool also includes a cable that extends between the tool head and the handle and that is coupled to the first engagement panel and the second engagement panel. An actuator mechanism is coupled to the cable and is manipulatable to move at least one of the first engagement panel and the second engagement panel via the cable relative to the frame to selectively engage and disengage a mop pad relative to the tool head. | 03-19-2015 |
Michel Bachmann, Vaux-Sur -Morges CH
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20100168673 | IMPLANTABLE DRUG DELIVERY DEVICE - The implantable drug delivery device comprises at least an implantable pump, a reservoir and a delivery chamber. | 07-01-2010 |
20110040141 | CLOSURE SYSTEM FOR TUBULAR ORGANS - In one embodiment, a surgically implantable adjustable ring comprises a ring body, which includes a closure system having first and second end parts. The ring body is designed to be closed around a tubular organ by the closure system, constricting the tubular organ by forming a loop. The first end part is shaped like a sleeve having a first and second end portions, and is designed to receive the second end part of the ring. The sleeve is substantially perpendicular to the main direction of the first end part of the ring, and the second end part of the ring includes a locking protrusion adapted to hold the sleeve in position, securing the ring in a closed position by engaging the locking protrusion in an opening disposed on the sleeve. | 02-17-2011 |
Michel Bachmann, Vaux S/morges CH
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20110152608 | FLOW CONTROL METHOD AND DEVICE - Apparatus and methods are provided comprising an implantable non-hydraulic ring that encircles and provides a controllable degree of constriction to an organ or duct and an external control that powers and controls operation of the ring. The ring includes a rigid dorsal periphery that maintains a constant exterior diameter, and a compliant constriction system that reduces intolerance phenomena. A high precision, energy efficient mechanical actuator is employed that is telemetrically powered and controlled, and maintains the ring at a selected diameter when the device is unpowered, even for extended periods. The actuator provides a reversible degree of constriction of the organ or duct, which is readily ascertainable without the need for radiographic imaging. Methods of use and implantation also are provided. | 06-23-2011 |
20140039250 | FLOW CONTROL METHOD AND DEVICE - Apparatus and methods are provided comprising an implantable non-hydraulic ring that encircles and provides a controllable degree of constriction to an organ or duct and an external control that powers and controls operation of the ring. The ring includes a rigid dorsal periphery that maintains a constant exterior diameter, and a compliant constriction system that reduces intolerance phenomena. A high precision, energy efficient mechanical actuator is employed that is telemetrically powered and controlled, and maintains the ring at a selected diameter when the device is unpowered, even for extended periods. The actuator provides a reversible degree of constriction of the organ or duct, which is readily ascertainable without the need for radiographic imaging. Methods of use and implantation also are provided. | 02-06-2014 |
Olaf Bachmann, Zurich CH
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20120173519 | PERFORMING PRE-AGGREGATION AND RE-AGGREGATION USING THE SAME QUERY LANGUAGE - A method includes: obtaining, at time intervals, subsets of data from a database using code of a query language; performing a pre-aggregation on the subsets of data to produce pre-aggregated data; storing the pre-aggregated data in the database; obtaining, in response to a query, at least some of the pre-aggregated data from the database, where the at least some of the pre-aggregated data is obtained using code from the query language used to obtain the subsets of data; and performing a re-aggregation on the pre-aggregated data to produce re-aggregated data | 07-05-2012 |
Patrice Bachmann, Winterthur CH
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20090270969 | DELIVERY SYSTEM HAVING A RELEASE MECHANISM FOR RELEASING AN OBJECT CARRIED BY A CATHETER AS WELL AS A RELEASE MECHANISM OF A DELIVERY SYSTEM - A delivery system having a release mechanism ( | 10-29-2009 |
20100030144 | BALLOON CATHETER AND METHOD FOR MANUFACTURING SAME - A balloon catheter comprises an outer shaft having a distal end, an inner shaft situated therein to form an annular fluid line and projecting beyond the distal end of the outer shaft, and a balloon which is dilatable under the influence of a fluid introduced through the fluid line under pressure. At its proximal end the balloon is attached in a fluid-tight manner to the distal end region of the outer shaft at a first attachment zone, and at its distal end is attached in a fluid-tight manner to the distal end region of the inner shaft at a second attachment zone. Between the attachment zones, in the undilated state the balloon is placed in longitudinal folds along its length. The balloon, at least at its distal end, has an untapered design with a thin wall thickness (d) which is essentially unchanged over the length of the balloon, and the longitudinal folds extend into the attachment zone at that location. | 02-04-2010 |
20100286608 | DRUG-COATED BALLOON CATHETER AND METHOD FOR THE PRODUCTION THEREOF - The invention relates to a drug-coated balloon catheter and to a method for producing the same. The balloon of the catheter includes (i) a main membrane, and (ii) an asymmetrical polymer membrane which is applied to an outside of the main membrane and into which at least one pharmaceutical active ingredient is introduced. | 11-11-2010 |
20110262684 | IMPLANT AND METHOD FOR PRODUCING THE SAME - An implant having a preferably hollow cylindrical basic structure. A nonwoven fabric is disposed in and/or on the basic structure, the nonwoven fabric preferably comprising biocompatible thermoplastic polyurethane and/or a polymer selected from the group consisting of polylactic acid; polycaprolactone, and a copolymer thereof, and/or a polymer including polyphosphazene. At least in at least one section of the implant, preferably at the proximal and/or distal ends of the implant, fastening means are provided or the nonwoven fabric is treated such that, at least in the expanded state of the implant, the protrusion of nonwoven fabric sections from the implant is significantly reduced. Furthermore, a method for producing such an implant is provided. | 10-27-2011 |
20120290082 | MECHANICAL TRANSCATHETER HEART VALVE PROSTHESIS - A mechanical transcatheter heart valve prosthesis including a support structure that can be expanded from a first size designed for minimally invasive insertion to a functional second size and a flexible heart valve made of a composite material containing woven fabric that is embedded in an elastic matrix and locally reinforced by fibers, the heart valve comprising a plurality of leaflets. | 11-15-2012 |
20120290083 | VALVE FOR A HEART VALVE PROSTHESIS - A valve for a heart valve prosthesis comprising a valve membrane composed of at least one spiral strip which, in the closed state of the valve membrane, assumes the form of an Archimedean spiral, wherein the outer edge regions of the spiral strip overlap an inner edge region of the spiral strip of a previous winding of the spiral. | 11-15-2012 |
Philipp Bachmann, Kusnacht CH
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20120277603 | Device and Method for Detecting and reporting of a stress condition of a person - For easy determination of the current stress condition of a person, a device is proposed that detects the pulse rate and therefrom additionally determines the heart rate variability—preferably by means of a fast Fourier transform. In addition, at least one parameter related to the history of one of the two values mentioned above shall be used. Preferably, the deviations of the cardiac frequency and of the heart rate variability from corresponding norm parameters are integrated and thus used as an additional stress indicator. | 11-01-2012 |
20150282723 | Device and Method for Detecting and Signalling a Stress State of a Person - For easy determination of the current stress condition of a person, a device is proposed that detects the pulse rate and therefrom additionally determines the heart rate variability. In addition, at least one parameter related to the history of one of the two above mentioned values shall be used. Preferably, the deviation of the cardiac frequency and of the heart rate variability from a reference value is integrated and used as an additional stress indicator. | 10-08-2015 |
Philipp Bachmann, Forch CH
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20100072368 | Spectral Measuring System - A spectral measuring system for determining substance properties using terahertz radiation comprises: one or more radiation sources of which at least one radiation source is adjustable or configurable with regard to its wavelength, wherein the first radiation source emits first radiation at a predetermined first wavelength; and is characterised by a sensor which responds to further radiation which is based on the radiation of the at least one radiation source; a control unit which is connected to the at least one radiation source and the sensor; wherein the control unit is configured to trigger at least one radiation source and to adjust the wavelength of the at least one adjustable radiation source as well as to read out the sensor. | 03-25-2010 |
Robert Bachmann, Colombier CH
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20080261167 | Accessory for Apex Locating Apparatus - The invention relates to an accessory for an apex locating apparatus, characterized in that it comprises a fitting ( | 10-23-2008 |
Rolf Bachmann, Busswil Be CH
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20150091679 | CONTACTLESS SWITCH - A switch includes a button which is connected to a ring-shaped permanent magnet that is magnetized along a z-axis, a guide member made from an non-ferromagnetic material inside which the button and the ring-shaped permanent magnet are arranged so as to be moveable along the z-axis, as well as at least one sensor that has a sensitive area that is arranged inside the ring-shaped permanent magnet and that is configured to measure a change in a magnetic field in the radial direction within a x-y-plane, wherein the x-axis and the y-axis lie orthogonally to the z-axis, respectively. | 04-02-2015 |
Stephan Bachmann, Allschwil CH
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20090012311 | PROCESS FOR THE PREPARATION OF INDOLE DERIVATIVES - A process for the preparation of indole derivatives of formula (I): | 01-08-2009 |
20090306423 | PROCESS FOR THE PREPARATION OF HALOGENATED BENZOIC ACID DERIVATIVES - The present invention comprises a process for the preparation of 3-chloro-2-fluoro-5-trifluoromethyl benzoic acid of the formula | 12-10-2009 |
20110040091 | PROCESS FOR THE PREPARATION OF (R)-2-PHENYL PROPIONIC ACID DERIVATIVES - The present invention relates to a process for the preparation of (R)-2-phenyl propionic acid derivatives of the formula | 02-17-2011 |
20110054174 | PROCESS FOR THE PREPARATION OF A GLUCOKINASE ACTIVATOR COMPOUND - The present invention relates to a process for the preparation of a compound of formula I, | 03-03-2011 |
20110105758 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED CYCLIC BETA-ARYL OR HETEROARYLCARBOCYCLIC ACIDS - The present invention relates to a process for the preparation of cis substituted cyclic β-aryl or heteroaryl carboxylic acid derivatives in high diastereo- and enantioselectivity by enantioselective hydrogenation in accordance with the following scheme | 05-05-2011 |
20110313196 | NOVEL PROCESS - The present invention relates to a process for the preparation of benzamide derivatives which are useful as intermediates in the preparation of pharmaceutically active compounds. | 12-22-2011 |
20120130121 | PROCESS FOR THE PREPARATION OF HALOGENATED BENZOIC ACID DERIVATIVES - The present invention comprises a process for the preparation of 3-chloro-2-fluoro-5-trifluoromethyl benzoic acid of the formula | 05-24-2012 |
20120330055 | PROCESS FOR THE PREPARATION OF HALOGENATED BENZOIC ACID DERIVATIVES - The present invention comprises a process for the preparation of 3-chloro-2-fluoro-5-trifluoromethyl benzoic acid of the formula | 12-27-2012 |
20130059833 | PDE10 MODULATORS - The present invention relates to compounds of formula (I) | 03-07-2013 |
20130085278 | METHODS FOR THE PREPARATION OF 5-[2-[7 (TRIFLUOROMETHYL)-5-[4- (TRIFLUOROMETHYL)PHENYL]PYRAZOLO [1,5-A]PYRIMIDIN-3-YL]ETHYNYL]-2-PYRIDINAMINE - The present invention provides methods for preparing 5-[2-[7-(trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]ethynyl]-2-pyridinamine (compound A), which is useful for the treatment of depression and other CNS disorders. The present methods are useful for preparing compound A on large scale in manufacturing facilities. | 04-04-2013 |
20130253201 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED CYCLIC BETA-ARYL OR HETEROARYL CARBOCYCLIC ACIDS - The present invention relates to a process for the preparation of cis substituted cyclic β-aryl or heteroaryl carboxylic acid derivatives in high diastereo- and enantioselectivity by enantioselective hydrogenation in accordance with the following scheme | 09-26-2013 |
Theo Bachmann, Haag CH
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20120152739 | METHOD FOR APPLYING A HIGH-TEMPERATURE LUBRICANT - The present invention relates to a method for applying hexagonal boron nitride to a rough surface, wherein it is intended for the boron nitride to be provided as a temperature-resistant lubricant of the surface. According to the invention, a pin composed of hexagonal boron nitride is rubbed with pressure over the rough surface, such that abraded boron nitride adheres to the surface. | 06-21-2012 |
20140193572 | METHOD FOR APPLYING A HIGH-TEMPERATURE LUBRICANT - The present invention relates to a method for applying hexagonal boron nitride to a rough surface, wherein it is intended for the boron nitride to be provided as a temperature-resistant lubricant of the surface. According to the invention, a pin composed of hexagonal boron nitride is rubbed with pressure over the rough surface, such that abraded boron nitride adheres to the surface. | 07-10-2014 |