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| 20090202631 | METHODS AND DOSAGE FORMS FOR CONTROLLED DELIVERY OF PALIPERIDONE AND RISPERIDONE - Dosage forms and methods for providing a substantially ascending rate of release of paliperidone or risperidone are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma paliperidone or risperidone concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma paliperidone or risperidone concentration occurrence in each 24 hour period. In addition, the peak plasma paliperidone or risperidone concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma paliperidone or risperidone concentration that occurs following administration of paliperidone or risperidone in an immediate-release dosage form. | 08-13-2009 |
| 20100028389 | HYDROMORPHONE THERAPY - A hydromorphone composition, a hydromorphone dosage form and a method for administering hydromorphone are disclosed, indicated for the management of pain. | 02-04-2010 |
| 20100196425 | OROS PUSH-STICK FOR CONTROLLED DELIVERY OF ACTIVE AGENTS - A sustained release dosage form is provided comprising a pharmaceutically active agent and pharmaceutically acceptable salts thereof and adapted to release as an erodible solid over a prolonged period of time, wherein the dosage form provides burst release of the pharmaceutically active agent without the use of an immediate release drug coating. The dosage form is able to deliver high doses of poorly soluble or slowly dissolving active agents at a controlled rate. Methods of using the dosage forms to treat disease or conditions in human patients are also disclosed. | 08-05-2010 |
| 20110195981 | METHODS AND DOSAGE FORMS FOR REDUCING SIDE EFFECTS OF BENZISOZAZOLE DERIVATIVES - Disclosed are dosage forms and methods comprising benzisoxazole derivatives. More particularly, disclosed are dosage forms, methods, and new uses of benzisoxazole derivatives that substantially reduce or substantially eliminate certain side effects of the benzisoxazole derivatives when dosed to a patient. | 08-11-2011 |
| 20110300217 | HYDROMORPHONE THERAPY - A hydromorphone composition, a hydromorphone dosage form and a method for administering hydromorphone are disclosed, indicated for the management of pain. | 12-08-2011 |
| 20120283275 | METHODS AND DOSAGE FORMS FOR REDUCING SIDE EFFECTS OF BENZISOZAZOLE DERIVATIVES - Disclosed are dosage forms and methods comprising benzisoxazole derivatives. More particularly, disclosed are dosage forms, methods, and new uses of benzisoxazole derivatives that substantially reduce or substantially eliminate certain side effects of the benzisoxazole derivatives when dosed to a patient. | 11-08-2012 |
| 20130209562 | METHODS AND DEVICES FOR PROVIDING PROLONGED DRUG THERAPY - Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug. | 08-15-2013 |
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| 20090075118 | Weld metal compositions for joining steel structures in the oil and gas industry - Provided are metal structures and methods of forming such structures for use in oil, gas and/or petrochemical applications that are joined with non-ferrous weld metal compositions or a high alloy weld metal compositions. The welded metal structures include two or more segments of ferrous or non-ferrous components, and fusion welds, friction stir welds or a combination thereof bonding adjacent segments of the components together, wherein the welds comprise a non-ferrous weld metal composition or a high alloy weld metal composition that is substantially different from the metal composition of the two or more components. The resultant welded structures exhibit improvements in fatigue resistance, toughness, strain capacity, strength, stress corrosion cracking resistance, and hydrogen embrittlement resistance compared to traditional iron-based weld compositions. The structures and methods of forming such structures are advantageous in joining metal components in applications for natural gas transportation and storage, oil and gas well completion and production, and oil and gas refinery and chemical plants. | 03-19-2009 |
| 20090155623 | High strength nickel alloy welds through precipitation hardening - Provided are precipitation hardened high strength nickel based alloy welds that yield improved properties and performance in joining high strength metals. The advantageous weldments include two or more segments of ferrous or non-ferrous components, and fusion welds, friction stir welds, electron beam welds, laser beam welds, or a combination thereof bonding adjacent segments of the components together, wherein the welds comprise a precipitation hardened nickel based alloy weld metal composition including greater than or equal to 1.4 wt % of combined aluminum and titanium based on the total weight of the nickel based alloy weld metal composition. Also provided are methods for forming the welds from the nickel based alloy weld compositions, wherein the precipitation hardening occurs in the as-welded condition. The nickel based welds do not require a separate heat treatment step after welding to produce advantageous strength properties. | 06-18-2009 |
| 20090301613 | Low Yield Ratio Dual Phase Steel Linepipe with Superior Strain Aging Resistance - A steel composition and method from making a dual phase steel therefrom. The dual phase steel may have carbon of about 0.05% by weight to about 0.12 wt %; niobium of about 0.005 wt % to about 0.03 wt %; titanium of about 0.005 wt % to about 0.02 wt %; nitrogen of about 0.001 wt % to about 0.01 wt %; silicon of about 0.01 wt % to about 0.5 wt %; manganese of about 0.5 wt % to about 2.0 wt %; and a total of molybdenum, chromium, vanadium and copper less than about 0.15 wt %. The steel may have a first phase consisting of ferrite and a second phase having one or more of carbide, pearlite, martensite, lower bainite, granular bainite, upper bainite, and degenerate upper bainite. A solute carbon content in the first phase may be about 0.01 wt % or less. | 12-10-2009 |
| 20100021761 | High strength nickel alloy welds through strain hardening - Provided are strain hardened high strength nickel based alloy welds that yield improved properties and performance in joining high strength metals. The advantageous weldments include two or more segments of ferrous or non-ferrous components, and fusion welds, friction stir welds, electron beam welds, laser beam welds, or a combination thereof bonding adjacent segments of the components together, wherein the welds comprise a strain hardened nickel based alloy weld metal composition including greater than or equal to 10 wt % Mo based on the total weight of the nickel based alloy weld metal composition. Also provided are methods for forming the welds from the nickel based alloy weld compositions. The strain hardened high strength nickel based alloy welds are useful in the oil, gas and petrochemical industry in applications for natural gas transportation and storage, oil and gas well completion and production, and oil and gas refinery and chemical plants. | 01-28-2010 |
| 20100136369 | High strength and toughness steel structures by friction stir welding - Provided are steel structures methods of making such steel structures including structural steel components bonded by friction stir weldments with advantageous microstructures to yield improved weldment strength and weldment toughness. In one form of the present disclosure, the steel structure includes: two or more structural steel components produced by conventional melting or secondary refining practices and friction stir weldments bonding faying surfaces of the components together, wherein the chemistry and grain size of the starting structural steel satisfies one or more of the following criteria: a) 0.02 wt %| 06-03-2010 | |
| 20110042069 | Coated sleeved oil and gas well production devices - Provided are coated sleeved oil and gas well production devices and methods of making and using such coated sleeved devices. In one form, the coated sleeved oil and gas well production device includes an oil and gas well production device including one or more bodies and one or more sleeves proximal to the outer or inner surface of the one or more bodies, and a coating on at least a portion of the inner sleeve surface, outer sleeve surface, or a combination thereof, wherein the coating is chosen from an amorphous alloy, a heat-treated electroless or electro plated based nickel-phosphorous composite with a phosphorous content greater than 12 wt %, graphite, MoS | 02-24-2011 |
| 20110120723 | Low Alloy Steels With Superior Corrosion Resistance For Oil Country Tubular Goods - The present application describes a steel composition that provides enhanced corrosion resistance. This steel composition includes one of vanadium in an amount of 1 wt % to 9 wt %, titanium in an amount of about 1 wt % to 9 wt %, and a combination of vanadium and titanium in an amount of 1 wt % to about 9 wt %. In addition, the steel composition includes carbon in an amount of 0.03 wt % to about 0.45 wt %, manganese in an amount up to 2 wt % and silicon in an amount up to 0.45 wt %. In one embodiment, the steel composition includes a microstructure of one of the following: ferrite, martensite, tempered martensite, dual phase ferrite and martensite, and dual phase ferrite and tempered martensite. Further, the present application describes a method for processing the steel composition and use of equipment such as oil country tubular goods, fabricated with the steel composition. | 05-26-2011 |
| 20120125490 | LOW YIELD RATIO DUAL PHASE STEEL LINEPIPE WITH SUPERIOR STRAIN AGING RESISTANCE - A steel composition and method from making a dual phase steel therefrom. The dual phase steel may have carbon of about 0.05% by weight to about 0.12 wt %; niobium of about 0.005 wt % to about 0.03 wt %; titanium of about 0.005 wt % to about 0.02 wt %; nitrogen of about 0.001 wt % to about 0.01 wt %; silicon of about 0.01 wt % to about 0.5 wt %; manganese of about 0.5 wt % to about 2.0 wt %; and a total of molybdenum, chromium, vanadium and copper less than about 0.15 wt %. The steel may have a first phase consisting of ferrite and a second phase having one or more of carbide, pearlite, martensite, lower bainite, granular bainite, upper bainite, and degenerate upper bainite. A solute carbon content in the first phase may be about 0.01 wt % or less. | 05-24-2012 |
| 20120160363 | HIGH MANGANESE CONTAINING STEELS FOR OIL, GAS AND PETROCHEMICAL APPLICATIONS - Provided are high manganese containing ferrous based components and their use in oil, gas and/or petrochemical applications. In one form, the components include 5 to 40 wt % manganese, 0.01 to 3.0 wt % carbon and the balance iron. The components may optionally include one or more alloying elements chosen from chromium, nickel, cobalt, molybdenum, niobium, copper, titanium, vanadium, nitrogen, boron and combinations thereof. | 06-28-2012 |
| 20130292362 | High Toughness Weld Metals With Superior Ductile Tearing Resistance - Weld metals and methods for welding ferritic steels are provided. The weld metals have high strength and high ductile tearing resistance and are suitable for use in strain based pipelines. The weld metal contains retained austenite and has a cellular microstructure with cell walls containing lath martensite and cell interiors containing degenerate upper bainite. The weld metals are comprised of between 0.02 and 0.12 wt % carbon, between 7.50 and 14.50 wt % nickel, not greater than about 1.00 wt % manganese, not greater than about 0.30 wt % silicon, not greater than about 150 ppm oxygen, not greater than about 100 ppm sulfur, not greater than about 75 ppm phosphorus, and the balance essentially iron. Other elements may be added to enhance the properties of the weld metal. The weld metals are applied using a power source with current waveform control which produces a smooth, controlled welding arc and weld pool in the absence of CO | 11-07-2013 |
| 20140261918 | ENHANCED WEAR RESISTANT STEEL AND METHODS OF MAKING THE SAME - Improved steel compositions and methods of making the same are provided. The present disclosure provides advantageous wear resistant steel. More particularly, the present disclosure provides high manganese (Mn) steel having enhanced wear resistance, and methods for fabricating high manganese steel compositions having enhanced wear resistance. The advantageous steel compositions/components of the present disclosure improve one or more of the following properties: wear resistance, ductility, crack resistance, erosion resistance, fatigue life, surface hardness, stress corrosion resistance, fatigue resistance, and/or environmental cracking resistance. In general, the present disclosure provides high manganese steels tailored to resist wear and/or erosion. | 09-18-2014 |
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| 20130324910 | ABLATION DEVICE WITH DRUG DELIVERY COMPONENT AND BIOPSY TISSUE-SAMPLING COMPONENT - An ablation device includes a handle assembly, an ablation electrode extending from the handle assembly, and one or more delivery needles extending from the handle assembly. The ablation electrode includes an ablation needle. The ablation needle includes a distal end portion including a drug delivery port defined therethrough. The ablation device also includes and a biopsy tool extending from the handle assembly. | 12-05-2013 |
| 20130324911 | ABLATION DEVICE WITH DRUG DELIVERY COMPONENT - An ablation system includes a source of electrosurgical energy, a source of coolant fluid, and an ablation electrode assembly operatively connected to the source of electrosurgical energy and fluidly-coupled to the source of coolant fluid. The ablation electrode assembly includes a hub defining a chamber therein and one or more electrically-conductive ablation needles extending from the hub. The ablation system also includes one or more delivery needles extending from the hub. The one or more delivery needles are selectively moveable from a first position, wherein the distal end of the delivery needle is disposed proximal to the distal end portion of the ablation needle, to at least a second position, wherein at least the distal end of the delivery needle is disposed distally beyond the distal end portion of the ablation needle. | 12-05-2013 |
| 20150065944 | DRUG-DELIVERY DEVICE FOR USE WITH ABLATION DEVICE - A drug-delivery device includes a body configured for attachment to a handle of an ablation device, a shaft portion defining a passageway therein, and a delivery lumen to provide for drug delivery to tissue. The body includes a proximal portion, a distal portion, and a contoured portion disposed therebetween. The contoured portion is configured for engagement with a contoured portion of the handle of the ablation device. The shaft portion includes a proximal end and a distal end. The proximal end of the shaft engages with an opening defined in the distal end of the body. The passageway of the shaft portion is configured to receive the delivery lumen slideably moveably therein. The delivery lumen includes a proximal portion and a distal portion. The drug-delivery device also includes a knob member coupled to the proximal portion of the delivery lumen. | 03-05-2015 |
| 20150065964 | DRUG-DELIVERY CANNULA ASSEMBLY - A drug-delivery cannula assembly includes a cannula housing adapted for receiving at least one obturator shaft of an obturator assembly therethrough, one or more cannulae, and a supply line coupled to the cannula housing. The cannula housing is adapted for receiving one or more obturator shafts of an obturator assembly therethrough. The one or more cannulae define a longitudinal axis and a passageway aligned with the longitudinal axis. The one or more cannulae each include a proximal end coupled to the cannula housing. The cannula housing is configured to fluidly-couple the one or more cannulae to a source of a drug delivery supply for supplying drugs via the supply line to the one or more cannulae. | 03-05-2015 |
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| 20100297209 | SOLVENT/POLYMER SOLUTIONS AS SUSPENSION VEHICLES - A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed. | 11-25-2010 |
| 20110104111 | Osmotic drug delivery devices containing suspension formulations comprising particles having active agents and nonaqueous single-phase vehicles - A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed. | 05-05-2011 |
| 20110264077 | SOLVENT/POLYMER SOLUTIONS AS SUSPENSION VEHICLES - A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed. | 10-27-2011 |
| 20120259318 | SOLVENT/POLYMER SOLUTIONS AS SUSPENSION VEHICLES - A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed. | 10-11-2012 |
| 20130034210 | SOLVENT/POLYMER SOLUTIONS AS SUSPENSION VEHICLES - A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed. | 02-07-2013 |
| 20130035670 | SOLVENT/POLYMER SOLUTIONS AS SUSPENSION VEHICLES - A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed. | 02-07-2013 |
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| 20090015403 | METHOD AND MECHANISM FOR ASSISTED DIAGNOSIS AND MAINTENANCE OF HEALTH MONITORING SYSTEM - The invention relates to a system and method of a health monitoring network which automates detection of faulty or failed sensors using real-time fault checking on a dynamically registered sensor data stream. The monitoring system and sensor network can provide a one-touch system to notify users when a sensor requires attention, without prior knowledge of the operational characteristics, installation method or configuration of sensors in the network. The network uses a decision engine to assist in maintenance according to a profile based on individual preferences and capabilities. | 01-15-2009 |
| 20090037634 | METHOD AND APPARATUS FOR EXTERNAL DATA TRANSFER IN A PERSONAL STORAGE DEVICE - A micro-watt class sensing device uses host-computer Input/Output (I/O) capabilities when transferring data to/from the host-computer directly from/to memory in the sensing device. This capability allows data to be directly transferred (downloaded/uploaded) to/from the host system at a higher rate when a host system is present. | 02-05-2009 |
| 20090043920 | SIMULTANEOUS PERSONAL SENSING AND DATA STORAGE - A personal sensing device that may be used for storing personal data and sensed data arbitrates and prioritizes competing requests for memory access from sensing, wireless, and wired interfaces. The personal sensing device enables power efficiency with burst-writes to the memory at higher data rates then an incoming sensor data stream without risk of data loss. Sensing operations coordinated by reconfigurable control logic are partitioned from storage operations coordinated by a multi-port memory controller. The interface between the functional partitioning uses message passing, status/control registers and buffering to reduce or eliminate system interdependencies. | 02-12-2009 |
| 20090184821 | Smart display device for independent living care - A wireless contextual prompting device provides contextual (context-aware) prompting in the home for applications such as Activities of Daily Living (ADL) monitoring, medication adherence, journaling, social messaging and coaching. The device combines the advantages of a small, wireless, battery-operated sensor that may be easily mounted at critical places in a person's daily routine with a low-power, high-contrast display panel that may be palm sized. The context may be displayed on the display screen as images, icons and/or text such that it is easy to interpret warnings by the young, elderly, or the language-challenged. | 07-23-2009 |
| 20100162024 | Enabling a Charge Limited Device to Operate for a Desired Period of Time - A charge limited device that has only limited access to power can be operated to ensure a given operating time. The operating time may, for example, correspond to the time period between recharging of a battery. Instead of simply reducing power consumption, a budget is developed that enables dynamic monitoring of power consumption over that time to ensure that actual power consumption conforms to the budget. | 06-24-2010 |
| 20110213938 | SIMULTANEOUS PERSONAL SENSING AND DATA STORAGE - A personal sensing device that may be used for storing personal data and sensed data arbitrates and prioritizes competing requests for memory access from sensing, wireless, and wired interfaces. The personal sensing device enables power efficiency with burst-writes to the memory at higher data rates then an incoming sensor data stream without risk of data loss. Sensing operations coordinated by reconfigurable control logic are partitioned from storage operations coordinated by a multi-port memory controller. The interface between the functional partitioning uses message passing, status/control registers and buffering to reduce or eliminate system interdependencies. | 09-01-2011 |
| 20120223835 | SMART DISPLAY DEVICE FOR INDEPENDENT LIVING CARE - A wireless contextual prompting device provides contextual (context-aware) prompting in the home for applications such as Activities of Daily Living (ADL) monitoring, medication adherence, journaling, social messaging and coaching. The device combines the advantages of a small, wireless, battery-operated sensor that may be easily mounted at critical places in a person's daily routine with a low-power, high-contrast display panel that may be palm sized. The context may be displayed on the display screen as images, icons and/or text such that it is easy to interpret warnings by the young, elderly, or the language-challenged. | 09-06-2012 |
| 20130009772 | METHOD AND MECHANISM FOR ASSISTED DIAGNOSIS AND MAINTENANCE OF HEALTH MONITORING SYSTEM - The invention relates to a system and method of a health monitoring network which automates detection of faulty or failed sensors using realt-time fault checking on a dynamically registered sensor data stream. The monitoring system and sensor network can provide a one-touch system to notify users when a sensor requires attention, without prior knowledge of the operational characteristics, installation method or configuration of sensors in the network. The network uses a decision engine to assist in maintenance according to a profile based on individual preferences and capabilities. | 01-10-2013 |
