Anu
Anu Ajithkumar, Neuchatel CH
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20120006343 | AEROSOL-GENERATING SUBSTRATE FOR SMOKING ARTICLES - Strands of homogenized tobacco material include at least one aerosol former, An aerosol-generating substrate includes a plurality of those strands of homogenized tobacco material. A smoking article may further include the aerosol-generating substrate. Those strands of homogenized tobacco material preferably have a mass-to-surface-area ratio of at least about 0.09 mg/mm | 01-12-2012 |
Anu Appaji, Plano, TX US
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20080267101 | Universal Browser - A method, a computer readable medium and a system for universal browsing that comprises, sending a request for a service by a mobile terminal to a service portal, determining a protocol needed to fulfill the request by the service portal, if the protocol needed is resident on the mobile terminal, determining a sensor that can fulfill the request, sending the request by the service portal to the sensor, establishing a connection between the mobile terminal and the sensor, and sending a response to the request to the mobile terminal via the connection. | 10-30-2008 |
Anu Hopia, Helsinki FI
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20100298261 | EDIBLE COMPOSITIONS FOR LOWERING CHOLESTEROL - The present invention is related to improved compositions for reducing serum total and/or LDL cholesterol levels. The compositions are combinations of dietary fibre and plant sterol. The compositions are used as such or more advantageously in food products and comprise one or several fibres, preferably β-glucan, in combination with one or several plant sterols and/or stanols in their free and/or esterified forms. | 11-25-2010 |
Anu Ilmonen, Espoo FI
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20140093648 | Method for surface modification of a body - The invention concerns a method for modification of the surface of a body, especially a film-shaped body, wherein a fibre-containing substance comprising nano-sized polysaccharide fibre particles is dispersed in a medium essentially composed of water and a polar solvent to form a suspension. The suspension is applied on the surface by a printing method. According to the invention, the viscosity of the suspension is adjusted to a range that is suitable for the printing method by adjusting the fibre concentration of the suspension. The invention concerns also a composition disposable onto the surface of a body, such as a film-shaped body, by a non-contact inkjet printing method. According to the invention, the composition comprises nanocellulose fibres suspended in a medium essentially composed of water and a polar solvent, miscible with water, wherein the concentration of nanocellulose fibres is 0.5 to 1.5%, preferably 0.5 to 1%, most preferably about 0.7% of said composition. | 04-03-2014 |
Anu Jalanko, Helsinki FI
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20150368641 | Methods to screen compounds for regulating USF1 activity and methods and compounds to treat cardiometabolic and lipid pathologies - The deficiency of Usf1 confers a remarkable number of clinically relevant beneficial metabolic effects in mice via activation of brown adipose tissue. The Usf1 deficient mice have high serum HDL-cholesterol and low triglyceride levels, a beneficial lipid profile opposite to that of human metabolic syndrome. The elevated HDL-C is associated with enhanced cholesterol efflux, and low triglycerides with decreased hepatic VLDL production and elevated triglyceride clearance. Despite their elevated food intake and lower physical activity, the Usf1 deficient mice are protected against diet-induced obesity. Their concomitant increase in energy expenditure is related to the activation of brown adipose tissue. The protective effects of Usf1 deficiency against obesity, insulin resistance, fatty liver, dyslipidemia, vascular inflammation, and atherosclerosis coupled with brown adipose tissue activation are demonstrated. Inhibition or silencing of USF1 is suggested as a therapeutic target to treat various human diseases. | 12-24-2015 |
Anu Kaukovirta-Norja, Espoo FI
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20100092651 | METHOD FOR FRACTIONATING OAT, PRODUCTS THUS OBTAINED, AND USE THEREOF - The invention relates to a method of preparing functionally valuable products, such as β-glucan, protein, starch and lipid concentrates from oat. The invention also relates to products thus obtained and to the use thereof. The invention further relates to the use of non-heat-treated or slightly heat-treated oat fat-extracted with supercritical extraction for preparing said products by using dry milling, sieving and air classification. | 04-15-2010 |
20110009613 | METHOD OF PROCESSING BETA-GLUCAN - The invention relates to a method of degrading plant-based β-glucan into a controlled molecular size by hydrolyzing β-glucan in a closed space under pressure by means of an acid at an elevated temperature. The invention also relates to a degraded β-glucan product. The β-glucan product obtained is useful in foodstuffs applications, such as beverages. | 01-13-2011 |
Anu Launiainen, Pirkkala FI
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20090021377 | Tamperproof tag - A tag including a substrate bordered by an outer edge and an inner circular edge. The substrate has a face side and a reverse side. An arrangement includes an antenna and an integrated circuit on a chip on the reverse side of the substrate. The integrated circuit on the chip is electrically connected to the antenna. An adhesive on the reverse side of the substrate covers the arrangement. A part of the arrangement has a greater adhesion to the adhesive than to the substrate. First cuts extend radially from the inner circular edge. Second cuts extend parallel to the first cuts from the outer edge. A region without cuts between the first cuts and the second cuts. | 01-22-2009 |
20120292399 | RFID TAG, A METHOD FOR MANUFACTURING AN RFID TAG, AND A PACKAGE - An RFID tag including a body part and a fixing part for attaching the body part to an object to be identified. The RFID tag includes at least one transponder. The body part and the fixing part include a single integrated piece. The fixing part is formed of a part with a ring-like or loop-like shape that can be fitted around at least a part of the object to be identified. A method for manufacturing an RFID tag and a package including several products separate from each other, including RFID tags for identifying the products separately from each other. | 11-22-2012 |
Anu Lokkiluoto, Helsinki FI
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20120067740 | METHOD FOR CONCENTRATING DILUTE SULFURIC ACID AND AN APPARATUS FOR CONCENTRATING DILUTE SULFURIC ACID - A method for concentrating dilute sulfuric acid involves feeding dilute sulfuric acid through at least two electrolytic cells depolarized by sulfur dioxide, and through a cation conductive membrane separating the cathode and anode sides in the electrolytic cell. Also provided is an apparatus for concentrating sulfuric acid, wherein at least a first electrolytic cell is in fluid communication with a second electrolytic cell, and wherein a cation conductive membrane separates the cathode and anode sides in the electrolytic cells. | 03-22-2012 |
Anu Muona, Harjamaki FI
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20130109750 | NOVEL ARYLAMIDE DERIVATIVES HAVING ANTIANDROGENIC PROPERTIES | 05-02-2013 |
Anu Närhi, Karjenniemi FI
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20100261006 | RELEASE PRODUCT - A release product including a basic substrate and a siliconized release layer. The basic substrate has a first side and a second side. The siliconized release layer has been applied on the first side of the basic substrate. The release product includes a coating layer which has been applied directly on either the first side of the basic substrate, or the second side of the basic substrate. The coating layer includes silica particles and a binder. | 10-14-2010 |
Anu Närhi, Karjenniemi FI
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20100261006 | RELEASE PRODUCT - A release product including a basic substrate and a siliconized release layer. The basic substrate has a first side and a second side. The siliconized release layer has been applied on the first side of the basic substrate. The release product includes a coating layer which has been applied directly on either the first side of the basic substrate, or the second side of the basic substrate. The coating layer includes silica particles and a binder. | 10-14-2010 |
Anu Parvatiyar, Lilburn, GA US
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20130053785 | MEDICAL ARTICLE SECUREMENT DEVICE - A securement device includes a retainer having at least one retention member extending into a channel of the retainer. The retention member is coupled to the retainer and includes a distal end. The distal end is movable relative to the retainer. The retention member can extend from the body and/or supports of the retainer on opposite sides of the channel axis. In some embodiments, a first set of retention members extends from a first support and a second set of retention members extends from the other support. The first set and the second set of retention members can be staggered laterally along the channel axis such that the lateral sides of the retainer are asymmetric which allow the same retainer to secure medical article having different shapes and sizes. The retainer may further include one or more abutment features or pills configured to contact the medical article. | 02-28-2013 |
Anu Pathria, San Diego, CA US
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20090094064 | Healthcare Insurance Claim Fraud and Error Detection Using Co-Occurrence - A healthcare insurance claim that includes variables characterizing aspects of a healthcare service for which reimbursement is sought is analyzed in order to determine whether there are any aspects that are indicative of fraud or error. This analysis includes generating score variables from the variables of the healthcare insurance claim and determining whether a presence of one or more of the pairs of variables is indicative of fraud or error based on levels of co-occurrence of the one or more pairs in historical healthcare insurance claims. If a positive determination occurs, then the healthcare insurance claim can be flagged or elevated for review by a user. Related techniques, apparatus, systems, and articles are also described. | 04-09-2009 |
Anu Punnoose, Wurzburg DE
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20110017944 | Method for Encapsulating Latent Heat Storage Material and Products Obtained Thereby - The invention relates to a method for producing an inorganic latent heat storage material that is surrounded by an encapsulating layer that is made of an inorganic-organic polymer material that comprises a metal and/or semi-metal oxygen network with embedded organic groups. The method is characterised in that a liquid or liquefied latent heat storage material, in the form of discrete units that are to be, respectively, encapsulated, is introduced into a liquid or viscous precursor material of the encapsulating material such that the encapsulating material solidifies when coming into contact with the outer surfaces of said latent heat storage material. The invention also relates to an inorganic latent heat storage material that is surrounded by an encapsulating layer and is present in said encapsulation, said encapsulating material being made of an inorganic-organic polymer material that comprises a (semi) metal oxygen network with embedded organic groups, connected, preferably at least partially to (semi) metal. Silane resins are well suited as precursor material. | 01-27-2011 |
Anu Remm, Tartu EE
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20130150262 | Method and Kit for Identifying Compounds Capable of Inhibiting Human Papilloma Virus Replication - This invention provides a method, kit and an in vitro system for identifying compounds capable of inhibiting Human Papilloma Virus replication at all the stages of viral replication cycle. The method, kit and in vitro system is applicable to all types of Human Papilloma Virus. The method enables high throughput screening of compounds inhibiting HPV replication in one or more phases of the cycle. | 06-13-2013 |
Anu Sadasiva, Maple Grove, MN US
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20080312645 | Vascular Sealing Device and Method Using Clot Enhancing Balloon and Electric Field Generation - An apparatus and method for closing an opening in a blood vessel wall is disclosed. The apparatus includes at least one member which is extended through a tissue tract formed through the epidermis and subcutaneous layer of skin and through the opening in the blood vessel. The member includes a proximal end and a distal end with the distal end being positionable proximate to the opening in the blood vessel wall. A positive electrode is positioned next to the distal end with a negative electrode being positioned next to the proximal end When the electrodes are energized an electric field is created therebetween, blood cells are attracted to the positive electrode, and a thrombus is formed at the opening in the blood vessel wall. The member may include a balloon at the distal end to temporarily occlude blood flow from the blood vessel to the tissue tract to facilitate formation of the thrombus. In addition, the shape of the balloon may be tailored to facilitate the formation of the thrombus including, but not limited to, the creation of pockets and self-supporting balloons | 12-18-2008 |
20080312667 | Self-Orientating Suture Wound Closure Device - A device is disclosed for providing an indication as to the relative position of a vessel or artery opening thereby facilitating the choice of which suturing or plugging technique to thereafter use. A disclosed device includes an outer tube and a collapsible foot slidably disposed within a distal end of the outer tube. The foot is connected to a shaft that passes through the tube and exits a proximal end thereof. The device may further include one or more threaded suture needles, a biodegradable plug or other wound closing device that is connected to another shaft. The collapsed or folded foot is pushed distally out of the tube and through the opening in the vessel whereupon the foot expands. Pulling the expanded foot in the proximal direction provides an indication as to the orientation of the opening in the vessel, which assists in determining the type of closing procedure to be carried out. The shaft connected to the foot is preferably connected to an indicator that indicates to the operator or physician that the vessel opening is in one of three positions on the vessel—left, top or right. As an alternative, the indicator bar may indicate a relative position in degrees, mm or μm in deviation from a top stick (or top position). | 12-18-2008 |
20080312683 | Apparatus and Method for Closing an Opening in a Blood Vessel Using Memory Metal and Collagen - An apparatus and method for closing an arteriotomy site are disclosed. The apparatus and method employ the use of a delivery sheath within which is provided an anchoring device formed of memory metal. The delivery sheath can be inserted through a tissue tract extending from an epidermal layer to the blood vessel wall, whereupon the anchoring device can be extended from the delivery sheath into the blood vessel itself The memory metal, once freed from the delivery sheath, obtains a non-linear or coiled configuration which can then be pulled back against the inner surface of the blood vessel to form a backstop. A biodegradable plug is then introduced into the tissue tract until it engages the backstop formed by the anchoring device thereby ensuring proper positioning of the biodegradable plug. The anchoring device can then be retracted through the biodegradable plug leaving the arteriotomy site substantially closed with hemostasis being formed therearound The various biodegradable plugs disclosed provide for improved retention of the biodegradable plug and proper positioning of the plug within the tissue tract. | 12-18-2008 |
Anu Sadisiva, Maple Grove, MN US
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20080312684 | Apparatus and Method for Closing an Opening in a Blood Vessel Using a Permanent Implant - An apparatus and method for closing an arteriotomy site is disclosed. The apparatus includes inner and outer frames adapted to sandwich a blood vessel wall therebetween. The inner and outer frames may be manufactured from memory metals such that they can be compressed during the insertion into the tissue tract proximate the arteriotomy site, and then deployed into an expanded configuration larger than the dimensions of the arteriotomy opening itself. A universal joint connects the inner and outer frames to ensure proper pivoting therebetween. In addition, polymeric coverings can be provided on the inner and outer frames to ensure closure, while a collagen plug can also be provided between inner and outer frames to facilitate closure as well. | 12-18-2008 |
20130172886 | VASCULAR SEALING DEVICE AND METHOD USING CLOT ENHANCING BALLOON AND ELECTRIC FIELD GENERATION - An apparatus and method for closing an opening in a blood vessel wall is disclosed. The apparatus includes at least one member which is extended through a tissue tract formed through the epidermis and subcutaneous layer of skin and through the opening in the blood vessel. The member includes a proximal end and a distal end with the distal end being positionable proximate to the opening in the blood vessel wall. A positive electrode is positioned next to the distal end with a negative electrode being positioned next to the proximal end When the electrodes are energized an electric field is created therebetween, blood cells are attracted to the positive electrode, and a thrombus is formed at the opening in the blood vessel wall. The member may include a balloon at the distal end to temporarily occlude blood flow from the blood vessel to the tissue tract to facilitate formation of the thrombus. In addition, the shape of the balloon may be tailored to facilitate the formation of the thrombus including, but not limited to, the creation of pockets and self-supporting balloons | 07-04-2013 |
Anu Sharma, El Cerrito, CA US
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20090258016 | Substituted imidazole derivatives - The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula: | 10-15-2009 |
20100280006 | 6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling - Benzoxazole and benzothiazole compounds and the stereoisomers, tautomers, solvates, oxides, esters, and prodrugs thereof and pharmaceutically acceptable salts thereof are disclosed. Compositions of the compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier, and uses of the compounds, either alone or in combination with at least one additional therapeutic agent are also disclosed. The embodiments are useful for inhibiting cellular proliferation, inhibiting the growth and/or metathesis of tumors, treating or preventing cancer, treating or preventing degenerating bone diseases such as rheumatoid arthritis, and/or inhibiting molecules such as CSF-1R. | 11-04-2010 |
20120225861 | 6-O-Substituted Benzoxazole and Benzothiazole Compounds and Methods of Inhibiting CSF-1R Signaling - Benzoxazole and benzothiazole compounds and the stereoisomers, tautomers, solvates, oxides, esters, and prodrugs thereof and pharmaceutically acceptable salts thereof are disclosed. Compositions of the compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier, and uses of the compounds, either alone or in combination with at least one additional therapeutic agent are also disclosed. The embodiments are useful for inhibiting cellular proliferation, inhibiting the growth and/or metathesis of tumors, treating or preventing cancer, treating or preventing degenerating bone diseases such as rheumatoid arthritis, and/or inhibiting molecules such as CSF-1R. | 09-06-2012 |
20130017196 | SUBSTITUTED IMIDAZOLE DERIVATIVES - The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula: | 01-17-2013 |
Anu Sreepathy, Bangalore IN
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20120208569 | FACILITATING A TEXT MESSAGE CONVERSATION USING TELE-LINKS - One embodiment of the present invention provides a system for facilitating a text message conversation using tele-links. During operation, the system receives a text message from a service at a mobile device, wherein the text message includes a tele-link, wherein the tele-link is comprised of a phone number. Next, the system receives a selection of the tele-link from a user at the mobile device. In response to the selection, the system then automatically initiates a call from the mobile device to a number indicated by the tele-link, wherein the act of calling the number results in the service sending a second text message to the mobile device. Finally, the system receives the second text message from the service at the mobile device. | 08-16-2012 |
20130176108 | AUTOMATED MECHANISM TO SWITCH USER DATA SETS IN A TOUCH-BASED DEVICE - A method to use a single touch-based device for a set of users involves analyzing a biometric signal of a user, obtained using a biometric sensor of the single touch-based device, to generate a biometric data item; determining an identity of the user by comparing the biometric data item to a set of biometric data items stored in the single touch-based device; activating, in response solely to the biometric signal and based on the identity of the user, a user data set residing on the single touch-based device, where the user data set belongs to the user; and performing, in response to a touch input from the user and activation of the user data set, a task on the single touch-based device using the user data set. | 07-11-2013 |
20140294304 | METHOD AND SYSTEM FOR CREATING OPTIMIZED IMAGES FOR DATA IDENTIFICATION AND EXTRACTION - A viewfinder screen display is generated and positioned such that a source document is displayed in the viewfinder screen display. Source document image blocks corresponding to different portions of the source document are then defined. For each source document image block, the image capture parameter of an image capture device is set to an optimized image capture parameter setting for the source document image block. The image capture device then captures an image block optimized image of the source document optimized for the source document image block. The optimized source document image blocks are then extracted from each image block optimized image of the source document. The extracted optimized source document image blocks are then aggregated and used to construct an image capture parameter optimized image of the source document. | 10-02-2014 |
20150030241 | METHOD AND SYSTEM FOR DATA IDENTIFICATION AND EXTRACTION USING PICTORIAL REPRESENTATIONS IN A SOURCE DOCUMENT - Data extraction templates are created and associated with source documents from a specific source document source. One or more known pictorial representations associated with one or more source document sources are then identified and key data is generated for the known pictorial representations. Source document data is then obtained and analyzed to identify potential pictorial representation data. Key data associated with the potential pictorial representation data is then generated and compared with the key data associated with one or more known pictorial representations and if the key data matches, the data extraction template associated with the matched known pictorial representations is obtained and used for identifying and extracting data from the source document data. | 01-29-2015 |
20150058774 | GESTURE-BASED VISUALIZATION OF FINANCIAL DATA - The disclosed embodiments provide a system that processes financial data. During operation, the system provides a user interface for displaying the financial data to a user. Upon detecting a gesture provided by the user through the user interface, the system identifies a context associated with the gesture. Next, the system displays a visualization of the financial data within the user interface based on the context. | 02-26-2015 |
20150063653 | METHOD AND SYSTEM FOR PROVIDING EFFICIENT FEEDBACK REGARDING CAPTURED OPTICAL IMAGE QUALITY - An optical image of a source document is captured. Two or more source document image test regions are then defined/determined. An optical image scan is performed on each source document image test region to determine if there are identifiable alpha-numeric characters or symbols present. If one or more of the source document image test regions are determined not to contain identifiable alpha-numeric characters, the captured optical image of the source document is determined to be of insufficient quality to identify and extract individual characters and symbols and it is recommended that optical images of source documents determined to be of insufficient quality to identify and extract individual characters and symbols be re-captured using an image capture device. | 03-05-2015 |
20150127659 | METHOD AND SYSTEM FOR DOCUMENT DATA EXTRACTION TEMPLATE MANAGEMENT - User acceptance of a given data extraction template and the number of data fields that the data extraction template can extract accurately is used to calculate data extraction template ranking, or a ranking score, to be associated with the data extraction template. Then the data extraction template having the highest data extraction template ranking score is used in a first attempt to extract data from a source documents of the source document type associated with the data extraction templates. As more data extraction templates associated with a given source document type are received, data extraction template ranking scores are updated/modified, and, in one example, the data extraction templates having the lowest data extraction template ranking scores are detected/eliminated. | 05-07-2015 |
20150261836 | EXTRACTING DATA FROM COMMUNICATIONS RELATED TO DOCUMENTS - The disclosed embodiments provide a system that processes data. During operation, the system obtains a communication associated with a document and extracts data associated with the document from the communication. Next, the system uses the extracted data from the communication and document data from the document to build a context associated with the document. The system then uses the context to facilitate use of the document by a user associated with the communication. | 09-17-2015 |
Anu Tammiste, Tartu EE
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20130096212 | Method and a Kit to Predict Response to Antidepressant Treatment - The present invention relates to the method for predicting the pharmacoresponse of antidepressants in patients diagnosed with major depression and panic disorder. According to the invention, SNP (rs41271330) in the coding region of the BMP5 gene together with the markers in linkage disequilibrium with this SNP could be used as predictors of SSRI treatment efficacy. The knowledge obtained by using the method disclosed in present invention has potential to increase the efficacy of pharmacological treatment in patients with major depression and panic disorder. The invention also provides a kit for detecting individual who are likely to respond to antidepressant treatment. | 04-18-2013 |
Anu Vaari, Vtt FI
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20130017457 | Multilayered StructureAANM Vaari; AnuAACI VttAACO FIAAGP Vaari; Anu Vtt FIAANM Ojala; Ville-MikkoAACI VttAACO FIAAGP Ojala; Ville-Mikko Vtt FIAANM Valkiainen; MattiAACI EspooAACO FIAAGP Valkiainen; Matti Espoo FIAANM Smolander; MariaAACI EspooAACO FIAAGP Smolander; Maria Espoo FIAANM Boer; HarryAACI SiuntioAACO FIAAGP Boer; Harry Siuntio FI - A multilayered structure suitable as an electrode in a power source and a method of producing the same. The structure comprises a conductive laminar layer; and an enzyme layer containing an essentially dry enzyme capable of oxidizing or dehydrogenating carbohydrate material under suitable conditions. Because the enzymatic anode layer and the fuel containing layer are not interacting during the production and since they are kept latent during storage time, the power source will remain stable for extended periods of time, thus increasing the utility of the power source. | 01-17-2013 |
Anu Wallecha, Yardley, PA US
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20110129499 | DUAL DELIVERY SYSTEM FOR HETEROLOGOUS ANTIGENS - Provided herein are recombinant | 06-02-2011 |
20120135033 | MULTIPLE DELIVERY SYSTEM FOR HETEROLOGOUS ANTIGENS - The invention is directed to an episomal recombinant nucleic acid encoding at least two heterologous antigens each fused to a PEST-endogenous polypeptide, vaccines comprising the same, methods of preparing same, and methods of inducing an immune response, and treating, inhibiting, or suppressing cancer or tumors comprising administering the same. | 05-31-2012 |
20140314708 | DUAL DELIVERY SYSTEM FOR HETEROLOGOUS ANTIGENS - Provided herein are recombinant | 10-23-2014 |
20140335120 | DUAL DELIVERY SYSTEM FOR HETEROLOGOUS ANTIGENS - Provided herein are recombinant | 11-13-2014 |
20150098964 | SUPPRESSOR CELL FUNCTION INHIBITION FOLLOWING LISTERIA VACCINE TREATMENT - This invention provides methods and compositions for using a live attenuated | 04-09-2015 |
20150238584 | COMPOSITIONS AND METHODS FOR PREVENTION OF ESCAPE MUTATION IN THE TREATMENT OF HER2/NEU OVER-EXPRESSING TUMORS - This invention provides compositions and methods for treating and vaccinating against a Her2/neu antigen-expressing tumor and inducing an immune response against dominant in a non-human animal. | 08-27-2015 |
20150297702 | COMPOSITIONS AND METHODS FOR PREVENTION OF ESCAPE MUTATION IN THE TREATMENT OF HER2/NEU OVER-EXPRESSING TUMORS - This invention provides compositions and methods for treating and vaccinating against a Her2/neu antigen-expressing tumor and inducing an immune response against dominant in a human subject. | 10-22-2015 |
20150366955 | COMPOSITIONS AND METHODS FOR PREVENTION OF ESCAPE MUTATION IN THE TREATMENT OF HER2/NEU OVER-EXPRESSING TUMORS - This invention provides compositions and methods for treating and vaccinating against a Her2/neu antigen-expressing tumor and inducing an immune response against dominant in a non-human animal. | 12-24-2015 |
Anu Wartiovaara, Helsinki FI
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20120064091 | DYSFUNCTION OF THE MITOCHONDRIAL RESPIRATORY CHAIN, METHODS FOR DIAGNOSIS, TREATMENT AND FOLLOW-UP - The invention relates to a method, of assessing whether a subject is affected with or at risk for developing a dysfunction of the mitochondrial respiratory chain, the method comprising determining the concentration of fibroblast growth factor 21 (FGF21) in a biological sample from the subject, and comparing it to the concentration of FGF21 in a biological sample from at least one normal control, wherein an increase in the concentration of FGF21 in the biological sample from the subject when compared to the concentration of FGF21 in the biological sample from at least one normal control is indicative of occurrence of the dysfunction of the mitochondrial respiratory chain in said subject, or of risk for developing said dysfunction. The invention also relates to a method for follow-up of a dysfunction of the mitochondrial respiratory chain in a subject diagnosed with but not being treated for said dysfunction, to a method for treating a subject having a dysfunction of the mitochondrial respiratory chain, to a method for determining whether a dysfunction of the mitochondrial respiratory chain in a subject diagnosed with and being treated for said dysfunction is responding to the treatment, and for selecting patients for clinical trials. | 03-15-2012 |