Patent application number | Description | Published |
20080281413 | METHOD AND APPARATUS FOR CREATING INCISIONS TO IMPROVE INTRAOCULAR LENS PLACEMENT - A system and method for inserting an intraocular lens in a patient's eye includes a light source for generating a light beam, a scanner for deflecting the light beam to form an enclosed treatment pattern that includes a registration feature, and a delivery system for delivering the enclosed treatment pattern to target tissue in the patient's eye to form an enclosed incision therein having the registration feature. An intraocular lens is placed within the enclosed incision, wherein the intraocular lens has a registration feature that engages with the registration feature of the enclosed incision. Alternately, the scanner can make a separate registration incision for a post that is connected to the intraocular lens via a strut member. | 11-13-2008 |
20100137982 | Method For Creating Incisions To Improve Intraocular Lens Placement - A system and method for inserting an intraocular lens in a patient's eye includes a light source for generating a light beam, a scanner for deflecting the light beam to form an enclosed treatment pattern that includes a registration feature, and a delivery system for delivering the enclosed treatment pattern to target tissue in the patient's eye to form an enclosed incision therein having the registration feature. An intraocular lens is placed within the enclosed incision, wherein the intraocular lens has a registration feature that engages with the registration feature of the enclosed incision. Alternately, the scanner can make a separate registration incision for a post that is connected to the intraocular lens via a strut member. | 06-03-2010 |
20100137983 | Intraocular Lens - A system and method for inserting an intraocular lens in a patient's eye includes a light source for generating a light beam, a scanner for deflecting the light beam to form an enclosed treatment pattern that includes a registration feature, and a delivery system for delivering the enclosed treatment pattern to target tissue in the patient's eye to form an enclosed incision therein having the registration feature. An intraocular lens is placed within the enclosed incision, wherein the intraocular lens has a registration feature that engages with the registration feature of the enclosed incision. Alternately, the scanner can make a separate registration incision for a post that is connected to the intraocular lens via a strut member. | 06-03-2010 |
20110172649 | METHOD AND SYSTEM FOR MODIFYING EYE TISSUE AND INTRAOCULAR LENSES - As shown in the drawings for purposes of illustration, a method and system for making physical modifications to intraocular targets is disclosed. In varying embodiments, the method and system disclosed herein provide many advantages over the current standard of care. Specifically, linear absorption facilitated photodecomposition and linear absorption facilitated plasma generation to modify intraocular tissues and synthetic intraocular lenses. | 07-14-2011 |
20110184395 | METHOD FOR LASER CAPSULOTOMY AND LENS CONDITIONING - A method of creating a capsulotomy and conditioning the crystalline lens is disclosed, wherein a laser is employed that provides improved performance by treating the capsule predominantly prior to treating the lens. | 07-28-2011 |
20110196350 | SYSTEM AND METHOD FOR PLASMA-MEDIATED MODIFICATION OF TISSUE - A system for cataract surgery on an eye of a patient is described. In one embodiment, the system comprises a first laser source configured to deliver a first laser beam in a pulsed form at a first pulse energy; a second laser source configured to deliver a second laser beam in a pulsed form at a second pulse energy greater than the first pulse energy; an scanning optical system, configured to: receive the first and second laser beams; and adjust a first focus position of the first laser beam, and a second focus position of the second laser beam, in up to three dimensions to direct the first and second laser beams onto one or more targeted tissue structure portions of the eye of the patient; a controller operatively coupled to the scanning optical system and configured to cause the scanning optical system to adjust the first focus position to photodisrupt a first tissue structure portion with the first laser beam, and subsequently adjust the second focus position to further photodisrupt the first tissue structure portion with the second laser beam. | 08-11-2011 |
20130096542 | SYSTEM AND METHOD FOR DETERMINING DOSIMETRY IN OPHTHALMIC PHOTOMEDICINE - A system and method for treating ophthalmic target tissue, including a light source for generating a beam of light, a beam delivery system that includes a scanner for generating patterns, and a controller for controlling the light source and delivery system to create a dosimetry pattern of the light beam on the ophthalmic target tissue. One or more dosage parameters of the light beam vary within the dosimetry pattern, to create varying exposures on the target tissue. A visualization device observes lesions formed on the ophthalmic target tissue by the dosimetry pattern. The controller selects dosage parameters for the treatment beam based upon the lesions resulting from the dosimetry pattern, either automatically or in response to user input, so that a desired clinical effect is achieved by selecting the character of the lesions as determined by the dosimetry pattern lesions. | 04-18-2013 |
20130096543 | SYSTEM AND METHOD FOR DETERMINING DOSIMETRY IN OPHTHALMIC PHOTOMEDICINE - A system and method for treating ophthalmic target tissue, including a light source for generating a beam of light, a beam delivery system that includes a scanner for generating patterns, and a controller for controlling the light source and delivery system to create a dosimetry pattern of the light beam on the ophthalmic target tissue. One or more dosage parameters of the light beam vary within the dosimetry pattern, to create varying exposures on the target tissue. A visualization device observes lesions formed on the ophthalmic target tissue by the dosimetry pattern. The controller selects dosage parameters for the treatment beam based upon the lesions resulting from the dosimetry pattern, either automatically or in response to user input, so that a desired clinical effect is achieved by selecting the character of the lesions as determined by the dosimetry pattern lesions. | 04-18-2013 |
20130317606 | APPARATUS FOR CREATING INCISIONS TO IMPROVE INTRAOCULAR LENS PLACEMENT - A system and method for inserting an intraocular lens in a patient's eye includes a light source for generating a light beam, a scanner for deflecting the light beam to form an enclosed treatment pattern that includes a registration feature, and a delivery system for delivering the enclosed treatment pattern to target tissue in the patient's eye to form an enclosed incision therein having the registration feature. An intraocular lens is placed within the enclosed incision, wherein the intraocular lens has a registration feature that engages with the registration feature of the enclosed incision. Alternately, the scanner can make a separate registration incision for a post that is connected to the intraocular lens via a strut member. | 11-28-2013 |
20140142558 | Method for Creating Incision to Improve Intraocular Lens Placement - A system and method for inserting an intraocular lens in a patient's eye includes a light source for generating a light beam, a scanner for deflecting the light beam to form an enclosed treatment pattern that includes a registration feature, and a delivery system for delivering the enclosed treatment pattern to target tissue in the patient's eye to form an enclosed incision therein having the registration feature. An intraocular lens is placed within the enclosed incision, wherein the intraocular lens has a registration feature that engages with the registration feature of the enclosed incision. Alternately, the scanner can make a separate registration incision for a post that is connected to the intraocular lens via a strut member. | 05-22-2014 |
20140207127 | SYSTEM AND METHOD FOR DETERMINING DOSIMETRY IN OPHTHALMIC PHOTOMEDICINE - A system and method for treating ophthalmic target tissue, including a light source for generating a beam of light, a beam delivery system that includes a scanner for generating patterns, and a controller for controlling the light source and delivery system to create a dosimetry pattern of the light beam on the ophthalmic target tissue. One or more dosage parameters of the light beam vary within the dosimetry pattern, to create varying exposures on the target tissue. A visualization device observes lesions formed on the ophthalmic target tissue by the dosimetry pattern. The controller selects dosage parameters for the treatment beam based upon the lesions resulting from the dosimetry pattern, either automatically or in response to user input, so that a desired clinical effect is achieved by selecting the character of the lesions as determined by the dosimetry pattern lesions. | 07-24-2014 |
20140296977 | Method for Creating Incision to Improve Intraocular Lens Placement - A system and method for insetting an intraocular lens in a patient's eye includes a light source for generating a light beam, a scanner for deflecting the light beam to form an enclosed treatment pattern that includes a registration feature, and a delivery system for delivering the enclosed treatment pattern to target tissue in the patient's eye to form an enclosed incision therein having the registration feature. An intraocular lens is placed within the enclosed incision, wherein the intraocular lens has a registration feature that engages with the registration feature of the enclosed incision. Alternately, the scanner can make a separate registration incision for a post that is connected to the intraocular lens via a strut member. | 10-02-2014 |
20150202456 | SYSTEM AND METHOD FOR OPTOGENETIC THERAPY - Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells. | 07-23-2015 |
20150217129 | SYSTEM AND METHOD FOR THERAPEUTIC MANAGEMENT OF OCULAR HYPERTENSION - One embodiment is directed to a method for treating hypertension within the eye of a patient, comprising: delivering an effective amount of polynucleotide comprising an exogenous receptor genetic material which is expressed in a targeted tissue structure of the eye, wherein the targeted tissue structure has been genetically modified to have light sensitive protein; waiting for a period of time to ensure that sufficient portions of the targeted tissue structure of the eye will express the desired light sensitive protein; and causing controlled mechanical changes to the permeability of the eye by directing light to the targeted tissue structure through a light deliver element optically intercoupled between a light source and the targeted tissue structure of the eye. | 08-06-2015 |
20150217133 | SYSTEM AND METHOD FOR THERAPEUTIC MANAGEMENT OF OCULAR HYPERTENSION - One embodiment is directed to a system for treating hypertension within the eye of a patient, comprising a light delivery element optically intercoupled between a light source and a targeted tissue structure of the eye; wherein the targeted tissue structure has been genetically modified to have light sensitive protein; and wherein exposure of the genetically modified targeted tissue structure to radiation delivered through the light delivery element modulates the contractility of the genetically modified targeted tissue structure to reduce an intraocular pressure within the eye. | 08-06-2015 |
20150230980 | INTRAOCULAR LENS - A system and method for inserting an intraocular lens in a patient's eye includes a light source for generating a light beam, a scanner for deflecting the light beam to form an enclosed treatment pattern that includes a registration feature, and a delivery system for delivering the enclosed treatment pattern to target tissue in the patient's eye to form an enclosed incision therein having the registration feature. An intraocular lens is placed within the enclosed incision, wherein the intraocular lens has a registration feature that engages with the registration feature of the enclosed incision. Alternately, the scanner can make a separate registration incision for a post that is connected to the intraocular lens via a strut member. | 08-20-2015 |
20150230987 | SYSTEM AND METHOD FOR PLASMA-MEDIATED MODIFICATION OF TISSUE - A method for cataract surgery on an eye of a patient includes scanning a first focus position of a first pulsed laser beam at a first pulse energy of between one-half microjoule and 50 microjoules in a first scanning pattern to photodisrupt a first tissue structure portion with a plurality of pulses of the first laser beam to form an incised surface; and afterwards, scanning a second focus position of a second pulsed laser beam having a second pulse energy being between 50 microjoules and 5,000 microjoules in a second scanning pattern that is co-registered to the first scanning pattern to further photodisrupt the same first tissue structure portion with the second laser beam to further separate segments of the first tissue structure along the incised surface. | 08-20-2015 |
20150246242 | SYSTEM AND METHOD FOR OPTOGENETIC THERAPY - Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells. | 09-03-2015 |
20150265458 | SYSTEM AND METHOD FOR THERAPEUTIC MANAGEMENT OF UNPRODUCTIVE COUGH - One embodiment is directed to a system for managing unproductive cough in a patient, comprising: an applicator comprising a resistive heating element and being configured to be positioned adjacent a portion of a targeted nerve tissue for treatment; a power source configured to provide electrical current to the resistive heating element; and a current controller operatively coupled to the power source and configured to raise the temperature of the portion of the targeted nerve tissue to inhibit nerve conduction. | 09-24-2015 |
20150265459 | SYSTEM AND METHOD FOR THERAPEUTIC MANAGEMENT OF UNPRODUCTIVE COUGH - One embodiment is directed to a method for managing unproductive cough in a patient, comprising: providing an applicator comprising a resistive heating element and being configured to be positioned adjacent a portion of a targeted nerve tissue for treatment; providing a power source configured to provide electrical current to the resistive heating element; providing a current controller operatively coupled to the power source and configured to raise the temperature of the portion of the targeted nerve tissue to inhibit nerve conduction; and modulating the temperature of the portion of the targeted nerve tissue to inhibit nerve conduction. | 09-24-2015 |
20150283397 | SYSTEM AND METHOD FOR THERAPEUTIC MANAGEMENT OF COUGH - One embodiment is directed to a system for controllably managing unproductive cough in a patient having a tissue structure that has been genetically modified to have light sensitive protein, comprising: a light delivery element configured to direct radiation to at least a portion of a targeted tissue structure; a light source configured to provide light to the light delivery element; and a controller operatively coupled to light source; wherein the controller is configured to be operated by an operator to illuminate the targeted tissue structure with radiation such that a membrane potential of cells comprising the targeted tissue structure is modulated at least in part due to exposure of the light sensitive protein to the radiation. | 10-08-2015 |
20150283398 | SYSTEM AND METHOD FOR THERAPEUTIC MANAGEMENT OF COUGH - One embodiment is directed to a method for controllably managing unproductive cough in a patient having a tissue structure that has been genetically modified to have light sensitive protein, comprising: providing a light delivery element configured to direct radiation to at least a portion of a targeted tissue structure, a light source configured to provide light to the light delivery element, and a controller operatively coupled to light source; and operating the controller to illuminate the targeted tissue structure with radiation such that a membrane potential of cells comprising the targeted tissue structure is modulated at least in part due to exposure of the light sensitive protein to the radiation. | 10-08-2015 |
20150335477 | METHOD AND SYSTEM FOR MODIFYING EYE TISSUE AND INTRAOCULAR LENSES - A system for ophthalmic surgery includes a laser source configured to deliver an ultraviolet laser beam comprising laser pulses having a wavelength between 320 nm and 370 nm to photodecompose one or more intraocular targets within the eye with chromophore absorbance. The pulse energy, the pulse duration, and the focal spot are such that an irradiance at the focal spot is sufficient to photodecompose the one or more intraocular targets without exceeding a threshold of formation of a plasma and an associated cavitation event. An optical system operatively coupled to the laser source and configured to focus the ultraviolet laser beam to a focal spot and direct the focal spot in a pattern into the one or more intraocular targets. The optical system focuses the laser beam at a numerical aperture that provides for the focal spot to be scanned over a scan range of 6 mm to 10 mm. | 11-26-2015 |
20150360049 | OPTOGENETIC THERAPIES FOR MOVEMENT DISORDERS - One embodiment is directed to a system for controllably managing motor function in the central nervous system of a patient having a targeted tissue structure that has been genetically modified to have light sensitive protein, comprising a light delivery element configured to direct radiation to at least a portion of a targeted tissue structure; a light source configured to provide light to the light delivery element; and a controller operatively coupled to light source; wherein the targeted tissue structure is a portion of the basal ganglia of the patient; and wherein the controller is configured to be automatically operated to illuminate the targeted tissue structure with radiation such that a membrane potential of cells comprising the targeted tissue structure is modulated at least in part due to exposure of the light sensitive protein to the radiation. | 12-17-2015 |
20150360050 | OPTOGENETIC THERAPIES FOR MOVEMENT DISORDERS - One embodiment is directed to a method for controllably managing motor function in the central nervous system of a patient having a targeted tissue structure that has been genetically modified to have light sensitive protein, comprising: providing a light delivery element configured to direct radiation to at least a portion of a targeted tissue structure, a light source configured to provide light to the light delivery element, and a controller operatively coupled to light source, wherein the targeted tissue structure is a portion of the basal ganglia of the patient; and automatically operating the controller to illuminate the targeted tissue structure with radiation such that a membrane potential of cells comprising the targeted tissue structure is modulated at least in part due to exposure of the light sensitive protein to the radiation. | 12-17-2015 |
20160030765 | SYSTEM AND METHOD FOR OPTOGENETIC THERAPY - One embodiment is directed to a system for controllably managing pain in the afferent nervous system of a patient having a targeted tissue structure that has been genetically modified to have light sensitive protein, comprising a light delivery element configured to direct radiation to at least a portion of a targeted tissue structure; a light source configured to provide light to the light delivery element; and a controller operatively coupled to light source; wherein the targeted tissue structure comprises a sensory neuron of the patient; and wherein the controller is configured to be automatically operated to illuminate the targeted tissue structure with radiation such that a membrane potential of cells comprising the targeted tissue structure is modulated at least in part due to exposure of the light sensitive protein to the radiation. | 02-04-2016 |
20160038755 | SYSTEM AND METHOD FOR OPTOGENETIC THERAPY - Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells. | 02-11-2016 |
20160038756 | SYSTEM AND METHOD FOR OPTOGENETIC THERAPY - Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells. | 02-11-2016 |
20160038757 | SYSTEM AND METHOD FOR OPTOGENETIC THERAPY - Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells. | 02-11-2016 |
20160038758 | SYSTEM AND METHOD FOR OPTOGENETIC THERAPY - Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells. | 02-11-2016 |
20160038759 | SYSTEM AND METHOD FOR OPTOGENETIC THERAPY - Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells. | 02-11-2016 |
20160038765 | SYSTEM AND METHOD FOR OPTOGENETIC THERAPY - Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells. | 02-11-2016 |
20160045764 | SYSTEM AND METHOD FOR OPTOGENETIC THERAPY - Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells. | 02-18-2016 |
20160051828 | SYSTEM AND METHOD FOR OPTOGENETIC THERAPY - Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells. | 02-25-2016 |
20160051830 | SYSTEM AND METHOD FOR OPTOGENETIC THERAPY - Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells. | 02-25-2016 |
20160051836 | SYSTEM AND METHOD FOR OPTOGENETIC THERAPY - Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells. | 02-25-2016 |
20160051837 | SYSTEM AND METHOD FOR OPTOGENETIC THERAPY - Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells. | 02-25-2016 |
20160051838 | SYSTEM AND METHOD FOR OPTOGENETIC THERAPY - Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells. | 02-25-2016 |
20160059030 | SYSTEM AND METHOD FOR OPTOGENETIC THERAPY - Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells. | 03-03-2016 |
20160074227 | Method and Apparatus for Creating Ocular Surgical and Relaxing Incisions - A system and method of treating target tissue in a patient's eye, which includes generating a light beam, deflecting the light beam using a scanner to form first and second treatment patterns, delivering the first treatment pattern to the target tissue to form an incision that provides access to an eye chamber of the patient's eye, and delivering the second treatment pattern to the target tissue to form a relaxation incision along or near limbus tissue or along corneal tissue anterior to the limbus tissue of the patient's eye to reduce astigmatism thereof. | 03-17-2016 |
20160074228 | Method and Apparatus for Creating Ocular Surgical and Relaxing Incisions - A system and method of treating target tissue in a patient's eye, which includes generating a light beam, deflecting the light beam using a scanner to form first and second treatment patterns, delivering the first treatment pattern to the target tissue to form an incision that provides access to an eye chamber of the patient's eye, and delivering the second treatment pattern to the target tissue to form a relaxation incision along or near limbus tissue or along corneal tissue anterior to the limbus tissue of the patient's eye to reduce astigmatism thereof. | 03-17-2016 |
20160082279 | SYSTEM AND METHOD FOR OPTOGENETIC THERAPY - Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells. | 03-24-2016 |
20160096034 | SYSTEM AND METHOD FOR OPTOGENETIC THERAPY - Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells. | 04-07-2016 |
20160096035 | SYSTEM AND METHOD FOR OPTOGENETIC THERAPY - Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells. | 04-07-2016 |
Patent application number | Description | Published |
20080281303 | METHOD AND APPARATUS FOR CREATING OCULAR SURGICAL AND RELAXING INCISIONS - A system and method of treating target tissue in a patient's eye, which includes generating a light beam, deflecting the light beam using a scanner to form first and second treatment patterns, delivering the first treatment pattern to the target tissue to form an incision that provides access to an eye chamber of the patient's eye, and delivering the second treatment pattern to the target tissue to form a relaxation incision along or near limbus tissue or along corneal tissue anterior to the limbus tissue of the patient's eye to reduce astigmatism thereof. | 11-13-2008 |
20090105699 | Scanner Laser Handpiece with Shaped Output Beam - A method for delivering electromagnetic radiation onto tissue to be ‘treated with the radiation includes delivering the radiation onto the tissue in a treatment-spot having a polygonal shape such as a rectangle or a hexagon. The polygonal shape is selected such that a region of the tissue to be treated’ can be completely covered by a plurality of such shapes essentially without overlapping the shapes. The radiation to be delivered is passed through a lightguide having a cross-section of the polygonal shape. Radiation exiting the lightguide is projected onto the tissue via a plurality of optical elements to provide the treatment-spot. | 04-23-2009 |
20100191226 | Method Of Patterned Plasma-Mediated Laser Trephination Of The Lens Capsule And Three Dimensional Phaco-Segmentation - System and method for making incisions in eye tissue at different depths. The system and method focuses light, possibly in a pattern, at various focal points which are at various depths within the eye tissue. A segmented lens can be used to create multiple focal points simultaneously. Optimal incisions can be achieved by sequentially or simultaneously focusing lights at different depths, creating an expanded column of plasma, and creating a beam with an elongated waist. | 07-29-2010 |
20110178511 | METHOD AND APPARATUS FOR PATTERNED PLASMA-MEDIATED LASER TREPHINATION OF THE LENS CAPSULE AND THREE DIMENSIONAL PHACO-SEGMENTATION - System and method for making incisions in eye tissue at different depths. The system and method focuses light, possibly in a pattern, at various focal points which are at various depths within the eye tissue. A segmented lens can be used to create multiple focal points simultaneously. Optimal incisions can be achieved by sequentially or simultaneously focusing lights at different depths, creating an expanded column of plasma, and creating a beam with an elongated waist. | 07-21-2011 |
20110178512 | METHOD AND APPARATUS FOR PATTERNED PLASMA-MEDIATED LASER TREPHINATION OF THE LENS CAPSULE AND THREE DIMENSIONAL PHACO-SEGMENTATION - System and method for making incisions in eye tissue at different depths. The system and method focuses light, possibly in a pattern, at various focal points which are at various depths within the eye tissue. A segmented lens can be used to create multiple focal points simultaneously. Optimal incisions can be achieved by sequentially or simultaneously focusing lights at different depths, creating an expanded column of plasma, and creating a beam with an elongated waist. | 07-21-2011 |
20120296394 | METHOD AND APPARATUS FOR CREATING OCULAR SURGICAL AND RELAXING INCISIONS - A system and method of treating target tissue in a patient's eye, which includes generating a light beam, deflecting the light beam using a scanner to form first and second treatment patterns, delivering the first treatment pattern to the target tissue to form an incision that provides access to an eye chamber of the patient's eye, and delivering the second treatment pattern to the target tissue to form a relaxation incision along or near limbus tissue or along corneal tissue anterior to the limbus tissue of the patient's eye to reduce astigmatism thereof. | 11-22-2012 |
20120316545 | METHOD AND APPARATUS FOR PATTERNED PLASMA-MEDIATED LASER TREPHINATION OF THE LENS CAPSULE AND THREE DIMENSIONAL PHACO-SEGMENTATION - System and method for making incisions in eye tissue at different depths. The system and method focuses light, possibly in a pattern, at various focal points which are at various depths within the eye tissue. A segmented lens can be used to create multiple focal points simultaneously. Optimal incisions can be achieved by sequentially or simultaneously focusing lights at different depths, creating an expanded column of plasma, and creating a beam with an elongated waist. | 12-13-2012 |
20130023864 | METHOD AND APPARATUS FOR PATTERNED PLASMA-MEDIATED LASER TREPHINATION OF THE LENS CAPSULE AND THREE DIMENSIONAL PHACO-SEGMENTATION - System and method for making incisions in eye tissue at different depths. The system and method focuses light, possibly in a pattern, at various focal points which are at various depths within the eye tissue. A segmented lens can be used to create multiple focal points simultaneously. Optimal incisions can be achieved by sequentially or simultaneously focusing lights at different depths, creating an expanded column of plasma, and creating a beam with an elongated waist. | 01-24-2013 |
20130197634 | APPARATUS FOR PATTERNED PLASMA-MEDIATED LASER TREPHINATION OF THE LENS CAPSULE AND THREE DIMENSIONAL PHACO-SEGMENTATION - System and method for making incisions in eye tissue at different depths. The system and method focuses light, possibly in a pattern, at various focal points which are at various depths within the eye tissue. A segmented lens can be used to create multiple focal points simultaneously. Optimal incisions can be achieved by sequentially or simultaneously focusing lights at different depths, creating an expanded column of plasma, and creating a beam with an elongated waist. | 08-01-2013 |
20140276676 | LASER CAPSULOVITREOTOMY - Methods and systems for performing laser-assisted surgery on an eye form a layer of bubbles in the Berger's space of the eye to increase separation between the posterior portion of the lens capsule of the eye and the anterior hyaloid surface of the eye. A laser is used to form the layer of bubbles in the Berger's space. The increased separation between the posterior portion of the lens capsule and the anterior hyaloid surface can be used to facilitate subsequent incision of the posterior portion of the lens capsule with decreased risk of compromising the anterior hyaloid surface. For example, the layer of bubbles can be formed prior to performing a capsulotomy on the posterior portion of the lens capsule. | 09-18-2014 |
20140276681 | MICROFEMTOTOMY METHODS AND SYSTEMS - Methods and systems for performing laser-assisted surgery on an eye form one or more small anchoring capsulotomies in the lens capsule of the eye. The one or more anchoring capsulotomies are configured to accommodate corresponding anchoring features of an intraocular lens and/or to accommodate one or more drug-eluting members. A method for performing laser-assisted eye surgery on an eye having a lens capsule includes forming an anchoring capsulotomy in the lens capsule and coupling an anchoring feature of the intraocular lens with the anchoring capsulotomy. The anchoring capsulotomy is formed by using a laser to incise the lens capsule. The anchoring feature can protrude transverse to a surface of the intraocular lens that interfaces with the lens capsule adjacent to the anchoring capsulotomy. | 09-18-2014 |
20140316386 | Method and Apparatus for Patterned Plasma-Mediated Laser Trephination of the Lens Capsule and Three Dimensional Phaco- Segmentation - System and method for making incisions in eye tissue at different depths. The system and method focuses light, possibly in a pattern, at various focal points which are at various depths within the eye issue. A segmented lens can be used to create multiple focal points simultaneously. Optimal incisions can be achieved by sequentially or simultaneously focusing lights at different depths, creating an expanded column of plasma, and creating a beam with an elongated waist. | 10-23-2014 |
20150038951 | Method and Apparatus for Patterned Plasma-Mediated Laser Trephination of the Lens Capsule and Three Dimensional Phaco-Segmentation - A laser surgical system for making incisions in ocular tissues during cataract surgery includes a laser system, an imaging device and a control system. The laser system includes a scanning assembly and a laser to generate a laser beam that incises ocular tissue. The imaging device acquires image data of a crystalline lens and constructs an image from the image data. The control system operates the imaging device to generate image data for the patient's crystalline lens, processes the image data to determine an anterior capsule incision scanning pattern for scanning a focal zone of the laser beam to perform an anterior capsule incision and operates the laser and the scanning assembly to scan the focal zone of the laser beam in the anterior capsule incision scanning pattern, wherein the focal zone is guided by the control system based on the image data. | 02-05-2015 |
20150038952 | Method and Apparatus for Patterned Plasma-Mediated Laser Trephination of the Lens Capsule and Three Dimensional Phaco-Segmentation - System and method for making incisions in eye tissue at different depths. The system and method focuses light, possibly in a pattern, at various focal points which are at various depths within the eye tissue. A segmented lens can be used to create multiple focal points simultaneously. Optimal incisions can be achieved by sequentially or simultaneously focusing lights at different depths, creating an expanded column of plasma, and creating a beam with an elongated waist. | 02-05-2015 |
20150100049 | SYSTEM AND METHOD FOR GENERATING TREATMENT PATTERNS - System and method for generating patterns P of aiming and treatment light on target eye tissue (e.g. the retina) of a patient's eye. The system includes light sources for treatment and aiming light, a scanner for generating patterns of spots of the generated light, a controller, and a graphic user interface that allows the user to select one of several possible spot patterns, adjust the spot density and/or spot size, and apply patterns with fixed or varied density. The patterns can be formed of interlaced sub-patterns and/or scanned without adjacent spots being consecutively formed to reduce localized heating. Partially or fully enclosed exclusion zones within the patterns protect sensitive target tissue from exposure to the light. | 04-09-2015 |
20150141968 | Method and Apparatus for Patterned Plasma-Mediated Laser Trephination of the Lens Capsule and Three Dimensional Phaco-Segmentation - System and method for making incisions in eye tissue at different depths. The system and method focuses light, possibly in a pattern, at various focal points which are at various depths within the eye tissue. A segmented lens can be used to create multiple focal points simultaneously. Optimal incisions can be achieved by sequentially or simultaneously focusing lights at different depths, creating an expanded column of plasma, and creating a beam with an elongated waist. | 05-21-2015 |
20150196428 | METHOD AND APPARATUS FOR CREATING OCULAR SURGICAL AND RELAXING INCISIONS - An optical beam scanning system for incising target tissue in a patient's eye includes a laser source configured to deliver a laser beam to produce optical breakdown and initiate a plasma-mediated process; an OCT imaging device used to create an image of eye tissue that includes the cornea; a delivery system for delivering the laser beam to the target tissue to form a cataract incision; a scanner operable to scan the focal spot of the laser beam to different locations within the patient's eye; and a controller operatively coupled to the laser source, the imaging device, and the scanner. The OCT device is configured to scan the eye tissue to generate imaging data used to define an incision pattern configured to incise one or more relaxation incisions into the cornea, so that the one or more relaxation incisions are formed starting from the inside and proceeding outward. | 07-16-2015 |
20150196429 | METHOD AND APPARATUS FOR CREATING OCULAR SURGICAL AND RELAXING INCISIONS - A scanning system for treating target tissue in a patient's eye includes an ultrafast laser source configured to deliver a laser beam comprising a plurality of laser pulses; an Optical Coherence Tomography (OCT) device configured to generate signals which may be used to create an image of the cornea and limbus of the eye of the patient; a scanner configured to focus and direct the laser beam in a pattern within the cornea or limbus to create incisions therein; and a controller operatively coupled to the laser source and scanner configured to control the scanner to adjust the position of the laser beam based upon the signals from the OCT device to create a cataract incision in the cornea or limbus that provides access for lens removal instrumentation to a crystalline lens of the patient's eye, and a relaxation incision in the cornea or limbus. | 07-16-2015 |
20150366712 | APPARATUS FOR PATTERNED PLASMA-MEDIATED LASER OPHTHALMIC SURGERY - A system for ophthalmic surgery on an eye includes: a pulsed laser which produces a treatment beam; an OCT imaging assembly capable of creating a continuous depth profile of the eye; an optical scanning system configured to position a focal zone of the treatment beam to a targeted location in three dimensions in one or more floaters in the posterior pole. The system also includes one or more controllers programmed to automatically scan tissues of the patient's eye with the imaging assembly; identify one or more boundaries of the one or more floaters based at least in part on the image data; iii. identify one or more treatment regions based upon the boundaries; and operate the optical scanning system with the pulsed laser to produce a treatment beam directed in a pattern based on the one or more treatment regions. | 12-24-2015 |
20160074214 | APPARATUS FOR PATTERNED PLASMA-MEDIATED LASER OPHTHALMIC SURGERY - A system for ophthalmic surgery on an eye includes: a pulsed laser which produces a treatment beam; an OCT imaging assembly capable of creating a continuous depth profile of the eye; an optical scanning system configured to position a focal zone of the treatment beam to a targeted location in three dimensions in one or more floaters in the posterior pole. The system also includes one or more controllers programmed to automatically scan tissues of the patient's eye with the imaging assembly; identify one or more boundaries of the one or more floaters based at least in part on the image data; iii. identify one or more treatment regions based upon the boundaries; and operate the optical scanning system with the pulsed laser to produce a treatment beam directed in a pattern based on the one or more treatment regions. | 03-17-2016 |
20160074216 | SYSTEM AND METHOD FOR DETERMINING DOSIMETRY IN OPHTHALMIC PHOTOMEDICINE - A system and method for treating ophthalmic target tissue, including a light source for generating a beam of light, a beam delivery system that includes a scanner for generating patterns, and a controller for controlling the light source and delivery system to create a dosimetry pattern of the light beam on the ophthalmic target tissue. One or more dosage parameters of the light beam vary within the dosimetry pattern, to create varying exposures on the target tissue. A visualization device observes lesions formed on the ophthalmic target tissue by the dosimetry pattern. The controller selects dosage parameters for the treatment beam based upon the lesions resulting from the dosimetry pattern, either automatically or in response to user input, so that a desired clinical effect is achieved by selecting the character of the lesions as determined by the dosimetry pattern lesions. | 03-17-2016 |
20160074218 | APPARATUS FOR PATTERNED PLASMA-MEDIATED LASER OPHTHALMIC SURGERY - A system for ophthalmic surgery on an eye includes: a pulsed laser which produces a treatment beam; an OCT imaging assembly capable of creating a continuous depth profile of the eye; an optical scanning system configured to position a focal zone of the treatment beam to a targeted location in three dimensions in one or more floaters in the posterior pole. The system also includes one or more controllers programmed to automatically scan tissues of the patient's eye with the imaging assembly; identify one or more boundaries of the one or more floaters based at least in part on the image data; iii. identify one or more treatment regions based upon the boundaries; and operate the optical scanning system with the pulsed laser to produce a treatment beam directed in a pattern based on the one or more treatment regions. | 03-17-2016 |
20160074229 | APPARATUS FOR PATTERNED PLASMA-MEDIATED LASER OPHTHALMIC SURGERY - A system for ophthalmic surgery on an eye includes: a pulsed laser which produces a treatment beam; an OCT imaging assembly capable of creating a continuous depth profile of the eye; an optical scanning system configured to position a focal zone of the treatment beam to a targeted location in three dimensions in one or more floaters in the posterior pole. The system also includes one or more controllers programmed to automatically scan tissues of the patient's eye with the imaging assembly; identify one or more boundaries of the one or more floaters based at least in part on the image data; iii. identify one or more treatment regions based upon the boundaries; and operate the optical scanning system with the pulsed laser to produce a treatment beam directed in a pattern based on the one or more treatment regions. | 03-17-2016 |
Patent application number | Description | Published |
20110206369 | FIBER OPTIC SECURITY SYSTEMS AND METHODS OF USING THE SAME - A fiber optic security system is provided. The fiber optic security system includes at least one length of fiber optic cable affixed to at least one item to be monitored using the fiber optic security system. The fiber optic security system also includes at least one local control node, the at least one local control node including at least one light source for generating and transmitting light through the at least one length of fiber optic cable, and the at least one local control node monitoring a status of the light. The fiber optic security system also includes a remote control unit for receiving information from the at least one local control node regarding the status of the light. | 08-25-2011 |
20120006109 | BOREHOLE SENSING AND CLAMPING SYSTEMS AND METHODS OF USING THE SAME - A sensing system configured for use in a borehole. The sensing system includes a body portion and a clamp arm engaged with the body portion. The clamp arm is configured to move between a retracted position and an extended position. The sensing system also includes an energy storage element engaged with the body portion. The energy storage element provides energy to move the clamp arm from the retracted position to the extended position. A method of using the sensing system is also provided. | 01-12-2012 |
20120227504 | FIBER OPTIC ACOUSTIC SENSOR ARRAYS AND SYSTEMS, AND METHODS OF FABRICATING THE SAME - A fiber optic acoustic sensor system. The fiber optic acoustic sensor system includes an optical source, and a fiber optic acoustic sensor array configured to receive an optical signal from the optical source. The fiber optic acoustic sensor array includes a core, a first polymer layer disposed on the core, an optical fiber wound around the first polymer layer, and a second polymer layer disposed on the first polymer layer such that the optical fiber is between the first polymer layer and the second polymer layer. | 09-13-2012 |
20120257208 | FIBER OPTIC TRANSDUCERS, FIBER OPTIC ACCELEROMETERS AND FIBER OPTIC SENSING SYSTEMS - A fiber optic transducer is provided. The fiber optic transducer includes a fixed portion configured to be secured to a body of interest, a moveable portion having a range of motion with respect to the fixed portion, a spring positioned between the fixed portion and the moveable portion, and a length of fiber wound between the fixed portion and the moveable portion. The length of fiber spans the spring. The fiber optic transducer also includes a mass engaged with the moveable portion. In one disclosed aspect of the transducer, the mass envelopes the moveable portion. | 10-11-2012 |
20120257209 | FIBER OPTIC MICROSEISMIC SENSING SYSTEMS - A fiber optic microseismic sensing system is provided. The system includes a plurality of nodes, each of the nodes including a surface portion, an underground portion, and an optical cable extending between the surface portion and the underground portion. The surface portion includes (1) an optical source for transmitting an optical signal along the optical cable to the underground portion, and (2) an optical receiver for receiving a return optical signal propagating along the optical cable from the underground portion. The underground portion includes at least one transducer, each of the at least one transducer including (1) a fixed portion configured to be secured to a body of interest, (2) a moveable portion having a range of motion with respect to the fixed portion, (3) a spring positioned between the fixed portion and the moveable portion, and (4) a mass engaged with the moveable portion. The optical cable includes a length of fiber wound between the fixed portion and the moveable portion of each of the at least one transducer, the length of fiber spanning the spring. In one disclosed aspect of the transducer, the mass envelopes the moveable portion. | 10-11-2012 |
20130025375 | FIBER OPTIC PIPELINE MONITORING SYSTEMS AND METHODS OF USING THE SAME - An optical detection system for monitoring a pipeline. The optical detection system includes a host node in the vicinity of or remote from, a pipeline to be monitored. The optical detection system includes (a) an optical source for generating optical signals, and (b) an optical receiver. The optical detection system also includes a plurality of fiber optic sensors local to the pipeline for converting at least one of vibrational and acoustical energy to optical intensity information, each of the fiber optic sensors having: (1) at least one length of optical fiber configured to sense at least one of vibrational and acoustical energy; (2) a reflector at an end of the at least one length of optical fiber; and (3) a field node for receiving optical signals from the host node, the field node transmitting optical signals along the at least one length of optical fiber, receiving optical signals back from the at least one length of optical fiber, and transmitting optical signals to the optical receiver of the host node. | 01-31-2013 |
20130034351 | FIBER OPTIC PERSONNEL SAFETY SYSTEMS AND METHODS OF USING THE SAME - A personnel monitoring system. The personnel monitoring system includes a host node having an optical source for generating optical signals, and an optical receiver. The personnel monitoring system also includes a plurality of fiber optic sensors for converting at least one of vibrational and acoustical energy to optical intensity information, each of the fiber optic sensors having: (1) at least one length of optical fiber configured to sense at least one of vibrational and acoustical energy; (2) a reflector at an end of the at least one length of optical fiber; and (3) a field node for receiving optical signals from the host node, the field node transmitting optical signals along the at least one length of optical fiber, receiving optical signals back from the at least one length of optical fiber, and transmitting optical signals to the optical receiver of the host node. | 02-07-2013 |
20130162432 | FIBER OPTIC SECURITY SYSTEMS AND METHODS OF USING THE SAME - A fiber optic security system is provided. The fiber optic security system includes at least one length of fiber optic cable affixed to at least one item to be monitored using the fiber optic security system. The fiber optic security system also includes at least one local control node, the at least one local control node including at least one light source for generating and transmitting light through the at least one length of fiber optic cable, and the at least one local control node monitoring a status of the light. The fiber optic security system also includes a remote control unit for receiving information from the at least one local control node regarding the status of the light. | 06-27-2013 |
20130201484 | OPTICAL DETECTION SYSTEMS AND METHODS OF USING THE SAME - An optical detection system. The optical detection system includes a host node having (a) an optical source for generating optical signals, and (b) an optical receiver. The optical detection system also includes a plurality of fiber optic sensors for converting at least one of vibrational and acoustical energy to optical intensity information, each of the fiber optic sensors having: (1) at least one length of optical fiber configured to sense at least one of vibrational and acoustical energy; (2) a reflector at an end of the at least one length of optical fiber; and (3) a field node for receiving optical signals from the host node, the field node transmitting optical signals along the at least one length of optical fiber, receiving optical signals back from the at least one length of optical fiber, and transmitting optical signals to the optical receiver of the host node. | 08-08-2013 |
20140105609 | LIGHT POWERED COMMUNICATION SYSTEMS AND METHODS OF USING THE SAME - A light powered communications system. The light powered communications system includes an audio control center having at least one optical source and at least one optical receiver. The light powered communications system also includes a plurality of optically powered remote communication systems located remote from the audio control center, each of the optically powered remote communication systems being configured to receive an optical signal from the audio control center. The light powered communication system also includes at least one length of fiber optic cable between the audio control center and each of the optically powered remote communication systems. | 04-17-2014 |
20140110124 | WELLBORE LEAK DETECTION SYSTEMS AND METHODS OF USING THE SAME - A leak detection system for a wellbore. The leak detection system includes: (1) at least one sensor configured to be positioned outside of a casing of the wellbore; (2) an interrogation system for sending signals to, and receiving signals from, the at least one sensor; and (3) an optical lead cable disposed between the interrogation system and the at least one sensor. A method of detecting a fluid leak in a wellbore is also disclosed. | 04-24-2014 |
20150177358 | FIBER OPTIC PERSONNEL SAFETY SYSTEMS AND METHODS OF USING THE SAME - A personnel monitoring system. The personnel monitoring system includes a host node having an optical source for generating optical signals, and an optical receiver. The personnel monitoring system also includes a plurality of fiber optic sensors for converting at least one of vibrational and acoustical energy to optical intensity information, each of the fiber optic sensors having: (1) at least one length of optical fiber configured to sense at least one of vibrational and acoustical energy; (2) a reflector at an end of the at least one length of optical fiber; and (3) a field node for receiving optical signals from the host node, the field node transmitting optical signals along the at least one length of optical fiber, receiving optical signals back from the at least one length of optical fiber, and transmitting optical signals to the optical receiver of the host node. | 06-25-2015 |
20150287300 | FIBER OPTIC SECURITY SYSTEMS AND METHODS OF USING THE SAME - A fiber optic security system is provided. The fiber optic security system includes at least one length of fiber optic cable affixed to at least one item to be monitored using the fiber optic security system. The fiber optic security system also includes at least one local control node, the at least one local control node including at least one light source for generating and transmitting light through the at least one length of fiber optic cable, and the at least one local control node monitoring a status of the light. The fiber optic security system also includes a remote control unit for receiving information from the at least one local control node regarding the status of the light. | 10-08-2015 |
20150300804 | FIBER OPTIC TRANSDUCERS, FIBER OPTIC ACCELEROMETERS AND FIBER OPTIC SENSING SYSTEMS - A fiber optic transducer is provided. The fiber optic transducer includes a fixed portion configured to be secured to a body of interest, a moveable portion having a range of motion with respect to the fixed portion, a spring positioned between the fixed portion and the moveable portion, and a length of fiber wound between the fixed portion and the moveable portion. The length of fiber spans the spring. The fiber optic transducer also includes a mass engaged with the moveable portion. In one disclosed aspect of the transducer, the mass envelopes the moveable portion. | 10-22-2015 |
20150369591 | OPTICAL DETECTION SYSTEMS AND METHODS OF USING THE SAME - An optical detection system. The optical detection system includes a host node having (a) an optical source for generating optical signals, and (b) an optical receiver. The optical detection system also includes a plurality of fiber optic sensors for converting at least one of vibrational and acoustical energy to optical intensity information, each of the fiber optic sensors having: (1) at least one length of optical fiber configured to sense at least one of vibrational and acoustical energy; (2) a reflector at an end of the at least one length of optical fiber; and (3) a field node for receiving optical signals from the host node, the field node transmitting optical signals along the at least one length of optical fiber, receiving optical signals back from the at least one length of optical fiber, and transmitting optical signals to the optical receiver of the host node. | 12-24-2015 |
Patent application number | Description | Published |
20090247425 | COMPOSITIONS AND METHODS FOR REUSING ARRAYS - The present disclosure relates generally to compositions and methods for the reuse of arrays, including microarrays. Specifically, the present disclosure discloses polynucleotide targets comprising nucleotide analogs that are not present within the probe polynucleotides immobilized on the array. The nucleotide-analog containing targets can be chemically modified to reduce their thermal stability and thus easier to remove from the array. In preferred embodiments, the disclosure relates to DNA probes hybridized to single-stranded deoxyribouridine-containing targets, the targets subsequently being chemically modified using a uracil DNA glycosylase and/or nuclease. Accordingly, the disclosure allows for the glycosylase treated, deoxyuridine-containing targets to be removed from the array by exposure to less stringent denaturing conditions than otherwise would have been required. Using less stringent denaturing conditions permits reuse of the array by reducing damage to the probe polynucleotides immobilized on the array during target removal. | 10-01-2009 |
20110052446 | FLOW CELLS AND METHODS OF FILLING AND USING SAME - Various flowcell configurations and systems are provided as are methods of making and using same. The flowcells, systems, and methods of use can be useful in carrying out sequencing reactions and next generation sequencing methods. | 03-03-2011 |
20120295819 | METHODS AND COMPOSITIONS FOR MULTIPLEX PCR - The present invention provides methods, compositions, kits, systems and apparatus that are useful for multiplex PCR of one or more nucleic acids present in a sample. In particular, various target-specific primers are provided that allow for the selective amplification of one or more target sequences. In one aspect, the invention relates to target-specific primers useful for the selective amplification of one or more target sequences associated with cancer or inherited disease. In some aspects, amplified target sequences obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing and used to detect the presence of genetic variants. | 11-22-2012 |
20130005613 | METHODS AND COMPOSITIONS FOR MULTIPLEX PCR - The present invention provides methods, compositions, kits, systems and apparatus that are useful for multiplex PCR of one or more nucleic acids present in a sample. In particular, various target-specific primers are provided that allow for the selective amplification of one or more target sequences. In one aspect, the invention relates to target-specific primers useful for the selective amplification of one or more target sequences associated with cancer or inherited disease. In some aspects, amplified target sequences obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing and used to detect the presence of genetic variants. | 01-03-2013 |
20130011881 | METHODS AND COMPOSITIONS FOR MULTIPLEX PCR - The present invention provides methods, compositions, kits, systems and apparatus that are useful for multiplex PCR of one or more nucleic acids present in a sample. In particular, various target-specific primers are provided that allow for the selective amplification of one or more target sequences. In one aspect, the invention relates to target-specific primers useful for the selective amplification of one or more target sequences associated with cancer or inherited disease. In some aspects, amplified target sequences obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing and used to detect the presence of genetic variants. | 01-10-2013 |
20130023011 | METHODS AND COMPOSITIONS FOR MULTIPLEX PCR - The present invention provides methods, compositions, kits, systems and apparatus that are useful for multiplex PCR of one or more nucleic acids present in a sample. In particular, various target-specific primers are provided that allow for the selective amplification of one or more target sequences. In one aspect, the invention relates to target-specific primers useful for the selective amplification of one or more target sequences associated with cancer or inherited disease. In some aspects, amplified target sequences obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing and used to detect the presence of genetic variants. | 01-24-2013 |
20130059738 | METHODS AND COMPOSITIONS FOR MULTIPLEX PCR - The present invention provides methods, compositions, kits, systems and apparatus that are useful for determining copy number variation of one or more nucleic acids present in a sample. In some aspects, the method includes various target-specific primers that allow for the selective amplification of one or more target nucleic acids in the sample. In yet another aspect, the invention relates to determining copy number variation with respect to gene or chromosome representation of a nucleic acid in the sample. In some aspects, the method for determining copy number variation of different target nucleic acids in a sample using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including diagnosis, predictive therapeutic regimes or other therapeutic purposes. | 03-07-2013 |
20130059762 | METHODS AND COMPOSITIONS FOR MULTIPLEX PCR - The present invention provides methods, compositions, kits, systems and apparatus that are useful for multiplex PCR of one or more nucleic acids present in a sample. In particular, various target-specific primers are provided that allow for the selective amplification of one or more target sequences. In one aspect, the invention relates to target-specific primers useful for the selective amplification of one or more target sequences associated with cancer or inherited disease. In some aspects, amplified target sequences obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing and used to detect the presence of genetic variants. | 03-07-2013 |
20130096014 | MULTIPLEX AMPLIFICATION OF POLYNUCLEOTIDES - The present invention provides methods, reagents and kits for carrying out a variety of assays suitable for analyzing polynucleotides or samples that include an amplification step performed in a multiplex fashion. Also provided are methods for analyzing and improving the efficiency of amplification and for carrying out gene expression analysis. | 04-18-2013 |
20140120529 | COMPOSITIONS, METHODS, SYSTEMS AND KITS FOR TARGET NUCLEIC ACID ENRICHMENT - The present invention provides methods, compositions, kits, systems and apparatus that are useful for isolating nucleic acid molecules from a sample. In particular, the methods generally relate to normalizing the concentration of target nucleic acid molecules from a sample. In one aspect, the invention relates to purifying a primer extension product from a primer extension reaction mixture. In some aspects, nucleic acid molecules obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing. | 05-01-2014 |
20140203169 | Flat-Field Imaging System and Methods of Use - A method of aligning a plurality of targets is provided. The method includes generating a plurality of targets. A third phase includes the plurality of targets. The method further includes combining a first phase, a second phase, and the third phase in a volume. The first phase, the second phase, and the third phase are substantially immiscible, and the third phase is in fluid communication with the first phase and the second phase, and the first phase, the second phase, and the third phase are operable to be in a configuration of the third phase between the first phase and the second phase in the volume. | 07-24-2014 |
20140248623 | System and Method for Determining Copies-per-Unit-Volume Using PCR and Flow Control of Droplets - Methods and systems for quantification of a target nucleic acid in a sample are provided. The method includes forming a plurality of discrete sample portions. Each of the plurality of discrete sample portions comprising a portion of the sample, and a reaction mixture. The method further includes amplifying the plurality of discrete sample portions to form a plurality of discrete processed sample portions. At least one discrete processed sample portion containing nucleic acid amplification reaction products. Fluorescence signals are detected from the at least one of the plurality of discrete processed sample portions to determine a presence of the at least one target nucleic acid. The method also includes determining the respective volumes of the plurality of the plurality of discrete processed sample portions, and estimating the number of copies-per-unit-volume of the at least one target nucleic acid in the sample. Estimating the number of copies-per-unit-volume is based on the number of discrete processed sample portions determined to contain the at least one target nucleic acid therein. | 09-04-2014 |
20150038342 | METHODS AND COMPOSITIONS FOR MULTIPLEX PCR - The present invention provides methods, compositions, kits, systems and apparatus that are useful for multiplex PCR of one or more nucleic acids present in a sample. In particular, various target-specific primers are provided that allow for the selective amplification of one or more target sequences. In one aspect, the invention relates to target-specific primers useful for the selective amplification of one or more target sequences associated with cancer or inherited disease. In some aspects, amplified target sequences obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing and used to detect the presence of genetic variants. | 02-05-2015 |
20150038343 | METHODS AND COMPOSITIONS FOR MULTIPLEX PCR - The present invention provides methods, compositions, kits, systems and apparatus that are useful for multiplex PCR of one or more nucleic acids present in a sample. In particular, various target-specific primers are provided that allow for the selective amplification of one or more target sequences. In one aspect, the invention relates to target-specific primers useful for the selective amplification of one or more target sequences associated with cancer or inherited disease. In some aspects, amplified target sequences obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing and used to detect the presence of genetic variants. | 02-05-2015 |
20150038375 | METHODS AND COMPOSITIONS FOR MULTIPLEX PCR - The present invention provides methods, compositions, kits, systems and apparatus that are useful for multiplex PCR of one or more nucleic acids present in a sample. In particular, various target-specific primers are provided that allow for the selective amplification of one or more target sequences. In one aspect, the invention relates to target-specific primers useful for the selective amplification of one or more target sequences associated with cancer or inherited disease. In some aspects, amplified target sequences obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing and used to detect the presence of genetic variants. | 02-05-2015 |
20150292002 | Multiplex Amplification of Polynucleotides - The present invention provides methods, reagents and kits for carrying out a variety of assays suitable for analyzing polynucleotides or samples that include an amplification step performed in a multiplex fashion. Also provided are methods for analyzing and improving the efficiency of amplification and for carrying out gene expression analysis. | 10-15-2015 |
20150307920 | METHODS AND COMPOSITIONS FOR MULTIPLEX PCR - The present invention provides methods, compositions, kits, systems and apparatus that are useful for multiplex PCR of one or more nucleic acids present in a sample. In particular, various target-specific primers are provided that allow for the selective amplification of one or more target sequences. In one aspect, the invention relates to target-specific primers useful for the selective amplification of one or more target sequences associated with cancer or inherited disease. In some aspects, amplified target sequences obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing and used to detect the presence of genetic variants. | 10-29-2015 |
20150307929 | METHODS AND COMPOSITIONS FOR MULTIPLEX PCR - The present invention provides methods, compositions, kits, systems and apparatus that are useful for multiplex PCR of one or more nucleic acids present in a sample. In particular, various target-specific primers are provided that allow for the selective amplification of one or more target sequences. In one aspect, the invention relates to target-specific primers useful for the selective amplification of one or more target sequences associated with cancer or inherited disease. In some aspects, amplified target sequences obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing and used to detect the presence of genetic variants. | 10-29-2015 |
20150322490 | METHODS AND COMPOSITIONS FOR MULTIPLEX PCR - The present invention provides methods, compositions, kits, systems and apparatus that are useful for multiplex PCR of one or more nucleic acids present in a sample. In particular, various target-specific primers are provided that allow for the selective amplification of one or more target sequences. In one aspect, the invention relates to target-specific primers useful for the selective amplification of one or more target sequences associated with cancer or inherited disease. In some aspects, amplified target sequences obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing and used to detect the presence of genetic variants. | 11-12-2015 |
20150344938 | MULTIPLEX TRANSCRIPTOME ANALYSIS - In some embodiments, the disclosure relates generally to methods, compositions, systems, apparatuses and kits comprising a multiplex nucleic acid amplification reaction that employs a plurality (e.g., hundreds, thousands, tens-of-thousands or hundreds-of-thousands) of different target-specific primer pairs that enable substantially simultaneous amplification of a plurality of different target sequences-of-interest in a single reaction mixture. In some embodiments, the multiplex nucleic acid amplification reaction generates a plurality of amplicons having sequences derived from a sample containing RNA or DNA, including whole transcriptome or genomic samples. In some embodiments, the sequences and abundances of at least some of the plurality of amplicons are characterized, optionally simultaneously or through a single assay, by suitable detection methods, including sequencing or other procedures known in the art. | 12-03-2015 |
20150353993 | COMPOSITIONS, METHODS, SYSTEMS AND KITS FOR TARGET NUCLEIC ACID ENRICHMENT - The present invention provides methods, compositions, kits, systems and apparatus that are useful for isolating nucleic acid molecules from a sample. In particular, the methods generally relate to normalizing the concentration of target nucleic acid molecules from a sample. In one aspect, the invention relates to purifying a primer extension product from a primer extension reaction mixture. In some aspects, nucleic acid molecules obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing. | 12-10-2015 |
20160046979 | METHODS AND COMPOSITIONS FOR MULTIPLEX PCR - The present invention provides methods, compositions, kits, systems and apparatus that are useful for determining copy number variation of one or more nucleic acids present in a sample. In some aspects, the method includes various target-specific primers that allow for the selective amplification of one or more target nucleic acids in the sample. In yet another aspect, the invention relates to determining copy number variation with respect to gene or chromosome representation of a nucleic acid in the sample. In some aspects, the method for determining copy number variation of different target nucleic acids in a sample using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including diagnosis, predictive therapeutic regimes or other therapeutic purposes. | 02-18-2016 |
Patent application number | Description | Published |
20110010168 | MULTIMODE CODING OF SPEECH-LIKE AND NON-SPEECH-LIKE SIGNALS - The invention relates to the coding of audio signals that may include both speech-like and non-speech-like signal components. It describes methods and apparatus for code excited linear prediction (CELP) audio encoding and decoding that employ linear predictive coding (LPC) synthesis filters controlled by LPC parameters, a plurality of codebooks each having codevectors, at least one codebook providing an excitation more appropriate for non-speech-like signals and at least one codebook providing an excitation more appropriate for speech-like signals, and a plurality of gain factors, each associated with a codebook. The encoding methods and apparatus select from the codebooks codevectors and/or associated gain factors by minimizing a measure of the difference between the audio signal and a reconstruction of the audio signal derived from the codebook excitations. The decoding methods and apparatus generate a reconstructed output signal from the LPC parameters, codevectors, and gain factors. | 01-13-2011 |
20130185124 | Mobile Card Processing Using Multiple Wireless Devices - A taxi fare system for a vehicle includes a meter, a wireless access point carried on the vehicle, a first mobile computing device a wireless, a second mobile computing device, a display and a credit card reader. The meter is configured to receive data from the vehicle indicating distance travelled, to measure waiting time, and to calculate an amount of a passenger fare based at least on the distance travelled and the waiting time. The first mobile computing device is positioned in a driver section of the vehicle and receives data from the meter. The second mobile computing device is positioned in a passenger section of the vehicle and receive card information from the card reader. The first and second mobile computing devices are configured to wirelessly connect to the wireless access point. | 07-18-2013 |
20130185208 | HANDLING TRANSACTION AND TRIP DATA - A method for a transaction with a taxi includes receiving from a mobile device in a vehicle an amount of a fare for a passenger trip, receiving trip information from the mobile device, the trip information including a start time, an end time and a distance traveled for the passenger trip, receiving a card number from the mobile device, submitting the transaction for authorization of payment, receiving an indication that the transaction is authorized, accessing financial payment information associated with an account of a driver of the vehicle, the financial payment information sufficient to make a deposit to a financial account of the driver, submitting the transaction for processing to make the deposit in the amount of the fare to the financial account of the driver, and sending the trip information to a computer system of the dispatch service. | 07-18-2013 |
20140052524 | Systems and Methods for Providing Transaction Rewards - A computer-implemented method for processing a transaction between a user and a merchant comprises receiving a request from the user to conduct a transaction with the merchant. The request is received by a computer system programmed to facilitate the transaction. Next, with the aid of a processor of the computer system, the transaction between the user and the merchant is processed. A rewards database of the computer system is then updated with a record of the processed transaction. The rewards database includes a history of one or more transactions between the user and the merchant and a milestone that must be met for the user to be provided a reward from the merchant. | 02-20-2014 |
20140052615 | Widgets for Use with Electronic Transaction Systems - A computer-implemented method for providing merchants to a user comprises providing, on a graphical user interface of an electronic device of the user, a directory of one or more merchant cards, each merchant card having information of or related to a given merchant. Each merchant card from the one or more merchant cards is configured to permit the user to initiate an electronic transaction with a merchant associated with the merchant card. At least one of the one or more merchant cards includes a widget that provides content that, with the aid of a processor, is generated in view of one or more user-specific merchant relevance criteria. | 02-20-2014 |
20140279436 | TRANSFERRING MONEY USING EMAIL - Method, systems, and apparatus for receiving the email message from a sender device; identifying, using data processing apparatus of a payment service system, a sender email address, a service email address, and one or more recipient email addresses from the email message; identifying, for the sender email address, a sender financial account associated with the payment service system and, for each of the one or more recipient email addresses, a respective recipient financial account associated with the payment service system; identifying a payment amount from a subject or body of the email message; submitting a request to transfer, using the payment service system, the payment amount from the respective sender financial account to the respective recipient financial account. | 09-18-2014 |
20150310404 | TRANSFERRING MONEY USING EMAIL - Methods, systems, and apparatus, including computer programs encoded on computer storage media, for sending or requesting money to or from multiple recipients using email. One of the methods includes receiving, at a user device, user input from a sender of a request to send a respective payment amount from a sender account of the sender with a payment service system to multiple recipient accounts of the payment service system. User input indicating respective recipient email addresses for the multiple recipients is received. A draft email message is generated, the draft email message being addressed to each of the multiple recipients, the draft email message including respective recipient email addresses for each of the multiple recipients. An indication that the sender sent the email message to the multiple recipients is sent to a payment service system. | 10-29-2015 |
20150325057 | Mobile Card Processing Using Multiple Wireless Devices - A payment transaction between a passenger and a driver may be processed using a mobile device of the passenger and a mobile device of the driver. For example, the mobile device of the passenger and the mobile device of the driver may be associated for processing the payment transaction. Fare data for a ride that is offered by the driver may be received from the mobile device that is associated with the driver and payment data for the passenger may be received from the mobile device that is associated with the passenger. A payment processing server may cause the payment transaction to be processed. | 11-12-2015 |