Ana P.
Ana P. Cotrim, Bethesda, MD US
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20140066472 | METHODS OF PREVENTING THE DEVELOPMENT OF MUCOSITIS AND RELATED DISORDERS - Disclosed is a method of preventing the development of mucositis in a subject undergoing radiation therapy or chemotherapy for a disease in need thereof comprising administering an effective amount of a mammalian target of rapamycin (mTOR) inhibitor, such as rapamycin, to the subject. Further disclosed is a method of increasing the lifespan of a normal oral keratinocyte and/or reducing oxidative stress in a normal epithelial cell, wherein the method comprises administering an effective amount of an mTOR inhibitor to a subject undergoing radiation therapy or chemotherapy for a disease in need thereof. | 03-06-2014 |
Ana P. Goncalvez, Rockville, MD US
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20100247549 | MONOCLONAL ANTIBODIES AGAINST DENGUE AND OTHER VIRUSES WITH DELETION IN FC REGION - The present invention relates to a variant of a parent polypeptide comprising an Fc region, which variant binds an Fc gamma receptor (FcγR) with lower affinity than the parent polypeptide and comprises a deletion of at least one amino acid in about position 100 to about position 150 in the Fc region and related nucleic acids, vectors, host cells and methods of producing the variant and methods for preventing or treating a disorder in a mammal. | 09-30-2010 |
20110033462 | HUMANIZED MONOCLONAL ANTIBODIES THAT SPECIFICALLY BIND AND/OR NEUTRALIZE JAPANESE ENCEPHALITIS VIRUS (JEV) AND THEIR USE - Disclosed herein are isolated humanized monoclonal antibodies that specifically bind Japanese encephalitis virus (JEV) with a binding affinity of about 1.0 nM or less. Nucleic acids encoding these antibodies, expression vectors including these nucleic acid molecules, and isolated host cells that express the nucleic acid molecules are also disclosed. Methods of treating, preventing, and/or ameliorating JEV infection in a subject with JEV also are disclosed. Additionally, the antibodies can be used to detect JEV in a sample, and methods of diagnosing JEV infection, or confirming a diagnosis of JEV infection in a subject, are disclosed herein that utilize these antibodies. | 02-10-2011 |
20130295090 | HUMANIZED MONOCLONAL ANTIBODIES THAT SPECIFICALLY BIND AND/OR NEUTRALIZE JAPANESE ENCEPHALITIS VIRUS (JEV) AND THEIR USE - Disclosed herein are isolated humanized monoclonal antibodies that specifically bind Japanese encephalitis virus (JEV) with a binding affinity of about 1.0 nM or less. Nucleic acids encoding these antibodies, expression vectors including these nucleic acid molecules, and isolated host cells that express the nucleic acid molecules are also disclosed. Methods of treating, preventing, and/or ameliorating JEV infection in a subject with JEV also are disclosed. Additionally, the antibodies can be used to detect JEV in a sample, and methods of diagnosing JEV infection, or confirming a diagnosis of JEV infection in a subject, are disclosed herein that utilize these antibodies. | 11-07-2013 |
Ana P. Goncalvez, Watertown, MA US
Patent application number | Description | Published |
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20130344058 | MONOCLONAL ANTIBODIES AGAINST DENGUE AND OTHER VIRUSES WITH DELETION IN FC REGION - The present invention relates to a variant of a parent polypeptide comprising an Fc region, which variant binds an Fc gamma receptor (FcγR) with lower affinity than the parent polypeptide and comprises a deletion of at least one amino acid in about position 100 to about position 150 in the Fc region and related nucleic acids, vectors, host cells and methods of producing the variant and methods for preventing or treating a disorder in a mammal. | 12-26-2013 |
Ana P. Keef, Allen, TX US
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20120059442 | STIMULATION LEAD, STIMULATION SYSTEM, AND METHOD FOR LIMITING MRI INDUCED CURRENT IN A STIMULATION LEAD - In one embodiment, a percutaneous stimulation lead for electrically stimulating tissue of a patient, comprises: a plurality of electrodes being electrically coupled to a plurality of terminals through a plurality of conductors within a lead body of the lead, wherein each electrode comprises a respective first surface exposed on an exterior surface of the stimulation lead to conduct current to or from tissue of the patient and a respective second surface disposed within an interior of the stimulation lead, the plurality of electrodes are arranged such that adjacent pairs of electrodes are capacitively coupled through a first surface of a first electrode of the respective pair and a respective second surface of a second electrode of the respective pair to substantially block current flow between adjacent electrodes at stimulation frequencies and to substantially pass current between adjacent electrodes at MRI frequencies. | 03-08-2012 |
Ana P. Nadu, Belo Horizonte BR
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20100158995 | SYSTEMS FOR DELIVERY AND RELEASE OF ANGIOTENSIN-(1-7) - The prior art lacks a formulation, application or product of D-Ala7-Angiotensin-(1-7) (A- | 06-24-2010 |