Patent application number | Description | Published |
20110034534 | siRNA compounds and methods of use thereof - The present invention relates to compounds, pharmaceutical compositions comprising same and methods of use thereof for the inhibition of certain genes, including SOX9, ASPP1, CTSD, CAPNS1, FAS and FAS ligand. The compounds and compositions are useful in the treatment of subjects suffering from diseases or conditions and or symptoms associated with diseases or conditions in which gene expression has adverse consequences. | 02-10-2011 |
20110229557 | METHODS FOR TREATING EYE DISORDERS - The present invention relates to compositions and methods for inhibiting loss of a retinal ganglion cell in a subject, comprising non-invasively applying to the surface of the eye of the subject an ophthalmic composition comprising a therapeutically effective amount of at 5 least one siRNA which down regulates expression of a target gene associated with loss of the retinal ganglion cell, thereby inhibiting loss of the retinal ganglion cell in the subject. The methods of the invention also relate to the use of chemically modified siRNA compounds possessing structural motifs which down-regulate the expression of human genes expressed in retinal tissue in the mammalian eye. | 09-22-2011 |
20120252875 | METHODS AND COMPOSITIONS FOR TREATING DISEASES, DISORDERS OR INJURY OF THE CNS - The present invention relates to non-invasive methods for treating diseases, disorders and injury to the central nervous system (CNS), and in particular to otic compositions and to methods of use thereof. | 10-04-2012 |
20140066493 | COMPOSITIONS AND METHODS FOR TREATMENT OF EAR DISORDERS - The present invention relates to pharmaceutical compositions useful for topical, non-invasive delivery of an oligonucleotide to the ear and to methods for the treatment of an ear disorder, including hearing loss arising from chemical-induced ototoxicity, acoustic trauma and presbycusis; and microbial infections. The method comprises topically administering to the ear of a subject in need thereof a pharmaceutical composition comprising an inhibitory oligonucleotide, a permeability enhancer and a pharmaceutically acceptable carrier, wherein the oligonucleotide reduces or inhibits expression of a gene associated with the ear disorder in the subject. | 03-06-2014 |
20150050328 | METHODS FOR TREATING EYE DISORDERS - The present invention relates to compositions and methods for inhibiting loss of a retinal ganglion cell in a subject, comprising non-invasively applying to the surface of the eye of the subject an ophthalmic composition comprising a therapeutically effective amount of at least one siRNA which down regulates expression of a target gene associated with loss of the retinal ganglion cell, thereby inhibiting loss of the retinal ganglion cell in the subject. The methods of the invention also relate to the use of chemically modified siRNA compounds possessing structural motifs which down-regulate the expression of human genes expressed in retinal tissue in the mammalian eye. | 02-19-2015 |
20150140108 | LIPIDATED GLYCOSAMINOGLYCAN PARTICLES FOR THE DELIVERY OF NUCLEIC ACIDS - There are provided compositions comprising lipidated glycosaminoglycan particles, methods for their preparation and uses thereof for the efficient in-vivo and in-vitro delivery of nucleic acids, such as, siRNA molecules. | 05-21-2015 |
Patent application number | Description | Published |
20130165147 | IRREGULAR PERIODIC LOCATION REPORTING MECHANISM - Described herein are techniques related to irregular periodic reporting of location-related information. The techniques enable the location engine to operate in irregular periodic reporting modes and dynamically adapt one or more different irregular periodic reporting patterns. The techniques may advantageously enable significant power saving while maintaining adequate accuracy in the reported location-related information to satisfy a given level of quality of service. This Abstract is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. | 06-27-2013 |
20130238921 | SYSTEMS AND METHODS FOR LOW POWER PROCESSING BASED ON LOCATION INFORMATION - Methods, systems, and computer-readable media are provided for offloading services and functionalities from a main host central processing unit (CPU) of a computing device to a dedicated power-efficient offload engine, thereby enabling a longer battery life for the device and an enhanced set of features. | 09-12-2013 |
20130311764 | SYSTEM FOR PROTECTION AND AUTHENTICATION OF LOCATION SERVICES WITH DISTRIBUTED SECURITY - Generally, this disclosure provides methods and apparatus for the protection and authentication of location services based on a distributed security system. The method may include exchanging security keys between a secure location processor (SLP) and a location requesting entity, the location requesting entity external to the SLP; obtaining location determination measurements, the obtaining performed by the SLP; determining a location based on the location determination measurements, the determining performed by the SLP; encrypting the location based on the security keys, the encrypting performed by the SLP; and transmitting the encrypted location from the SLP to the location requesting entity. | 11-21-2013 |
20140085136 | SYSTEMS AND METHODS FOR TIME SYNCHRONIZATION - A method and system for time synchronization in a mobile device are disclosed. The method includes negotiating a synchronization schedule. The synchronization schedule defines a plurality of synchronization times for receiving synchronization messages. The method further includes transitioning the mobile device from a first state to a second state to receive a synchronization message. The mobile device uses less power in the first state than the second state and the mobile device cannot receive the synchronization message when in the first state. The method further includes synchronizing a clock component in response to receiving the synchronization message. | 03-27-2014 |
20140179337 | SYSTEMS AND METHODS FOR SELECTING AN OPTIMAL LOCATION SERVICE - Systems and methods are described herein for selecting a location service based, at least in part, on service availability, capability, and/or accuracy. In one instance, the selection may be based, at least in part, on which location service that may result in the least amount of power consumed by a user device. The selection may also be balanced between user preferences and application demands for accurate and timely location services information. | 06-26-2014 |
20140179343 | OPTIMIZING LOCATION SYSTEM CONFIGURATION EXCHANGES THROUGH DYNAMIC LOCATION WORKING PROFILES - A wireless location information system, device, and method are presented that include location system components (LSCs) that perform location-based operations; one or more location work profiles (LWPs) associated with each of the LSCs, in which the LWPs include configuration information of the LSCs; and a controller that controls the configuration information exchanges between the LSCs. As such, the controller component provides, in advance, one or more LWPs to each LSC, in which each of the LWPs is designated with a unique identifier and, upon a change in operational status, the controller provides the LSCs with only the identifier of the LWP affected by the change. | 06-26-2014 |
20140179366 | METHODS AND SYSTEMS FOR MULTI-DIRECTIONAL TIME PRESERVATION DISTRIBUTION IN MULTI-COMMUNICATION CORE DEVICES - A system and method for the distribution of time signals is available for devices with multiple communication cores. An embodiment may or may not use a centralized manager for the management of time preservation. When a communication core in a multiple communication core device requires timing information, it may request the time information from another communication core or from the centralized manager. The centralized manager, if present, can obtain time information from an external source or from one of the communication cores. The result can be reduced power consumption at a lower cost. | 06-26-2014 |
20140253390 | PASSIVE WIRELESS TRANSMITTER AUTHENTICATION USED FOR RECEIVER LOCATION DETERMINATION - A client device includes an application to request a client device location, and a receiver to receive a signal from a transmitter. The receiver extracts a transmitter identifier (ID) and a wave propagation parameter (WPP) from the signal. A validator validates the extracted transmitter ID based on comparisons of the extracted ID against a list of pre-assigned transmitter IDs. A location calculator computes the client device location based at least in part on the extracted WPP and provides the computed client device location to the application, if the transmitter ID is validated by the validator. | 09-11-2014 |
20150189612 | METHODS AND SYSTEMS FOR MULTI-DIRECTIONAL TIME PRESERVATION DISTRIBUTION IN MULTI-COMMUNICATION CORE DEVICES - A system and method for the distribution of time signals is available for devices with multiple communication cores. An embodiment may or may not use a centralized manager for the management of time preservation. When a communication core in a multiple communication core device requires timing information, it may request the time information from another communication core or from the centralized manager. The centralized manager, if present, can obtain time information from an external source or from one of the communication cores. The result can be reduced power consumption at a lower cost. | 07-02-2015 |
Patent application number | Description | Published |
20080254820 | Power Control in Wireless Communications Networks During Hand-Over - A method and devices are provided for adapting the transmission power level of a mobile terminal during a handover phase at which the mobile terminal switches from one base station to another. The method provided comprises applying values of operating parameters that characterize both base stations and adapting the transmission power level to an acceptable level at which communications transmitted from the terminal to the second station would be properly received without applying further increase in the transmission power while ensuring that the communications transmitted by the mobile terminal to the second base station, will not cause severe interference to communications exchanged between the second base station and the other terminals communicating therewith. | 10-16-2008 |
20080291831 | Dynamic Management of Wireless Transmissions - There is provided a method and devices for dynamically controlling transmission of communications in a wireless network, which comprises a managing entity and a managed entity that communicate which each other. The managed entity transmits updating information that includes indications of current resources available thereat and/or indications that relate to the reception of communications transmitted by the managing entity. A reporting rate for transmitting the updating information by the managed entity to the managing entity is then determined, and based on the reporting rate that has been determined—modifying, if required, parameters associated with the wireless link extending between the two entities so as to affect changes in the operating conditions at one or both of these entities. | 11-27-2008 |
20090086657 | HYBRID AUTOMATIC REPEAT REQUEST BUFFER FLUSHING MECHANISM - A novel and useful buffer flushing mechanism for use in a communications link. Using hybrid automatic repeat request (HARQ) protocol mechanisms, network elements in a radio access network initiate a HARQ buffer flushing operation. Network elements on both ends of a communication link can autonomously initiate coordinated or uncoordinated flushing of their respective HARQ process buffers based on internal algorithms and/or criteria previously negotiated between the two elements. The flushing operation may be performed on all or a part of the buffer (transmit and/or receive) or on certain complete or partial accumulated information. The criteria may comprise any suitable data including, for example, timeout data, thresholds based on one or more link quality parameters, data measurements exceeding a threshold, etc. which can be used to trigger a buffer flushing event. | 04-02-2009 |
20090180451 | APPARATUS FOR AND METHOD OF COORDINATING TRANSMISSION AND RECEPTION OPPORTUNITIES IN A COMMUNICATIONS DEVICE INCORPORATING MULTIPLE RADIOS - A novel and useful apparatus for and method of coordinating the allocation of transmission and reception availability and/or unavailability periods for use in a communications device incorporating collocated multiple radios. The mechanism provide both centralized and distributed coordination to enable the coordination (e.g., to achieve coexistence) of multiple radio access communication devices (RACDs) collocated in a single device such as a mobile station. A distributed activity coordinator modifies the activity pattern of multiple RACDs. The activity pattern comprises a set of radio access specific modes of operation, (e.g., IEEE 802.16 Normal, Sleep, Scan or Idle modes, 3GPP GSM/EDGE operation mode (PTM, IDLE, Connected, DTM modes), etc.) and a compatible set of wake-up events, such as reception and transmission availability periods. To prevent interference and possible loss of data, a radio access is prevented from transmitting or receiving data packets while another radio access is transmitting or receiving. In the event two or more RATs desire to be active at the same time, the mechanism negotiates an availability pattern between the MS and a corresponding BS to achieve coordination between the RATs. | 07-16-2009 |
20090219849 | APPARATUS FOR AND METHOD OF MULTICAST AND BROADCAST SERVICE (MBS) MACRO-DIVERSITY BASED INFORMATION PROCESSING - A novel and useful apparatus for and method of multicast and broadcast service (MBS) macro-diversity based information processing for use in MBS enabled wireless communication systems. MBS allocations and transmissions from base stations are not coordinated and independent of each other. The characteristics of the MBS signal, such as waveform, modulation, timing and frequency domain, used for transmissions in one or more MBS zones by a base station are uncoordinated and unsynchronized with respect to transmissions in other base stations or MBS zones. They all, however, contain the same information content and relate to the same CID (MCID and/or SA). The MS, using multiple detection techniques, uses time and frequency diversity reception techniques to combine MBS transmissions received from multiple base stations. Base stations and/or the network inform mobile stations of whether or not uncoordinated MBS data transmission is supported on the network via a TLV transmitted during the MBS connection setup process. If supported, mobile stations can receive multiple MBS data signals, combining them to generate a single MBS data output stream. | 09-03-2009 |
20090290555 | Autonomous anonymous association between a mobile station and multiple network elements in a wireless communication system - A novel and useful autonomous association mechanism for use in user equipment (UE) network connections in one or more cellular communications systems. The handover process is optimized by improving the selection of target base stations and optimizing the discontinuity period from the time of disconnection from a serving base station and connection to a target base station and by establishing anonymous bidirectional communications with base stations. The mechanism facilitates multiple cell association in a network unaware manner while preserving single endpoint connectivity. The UE does not need to negotiate for or receive pre-allocated opportunities from the network for making associations with neighboring base stations. Association opportunities are created by the UE autonomously in accordance with UE activity patterns. Association opportunities are used to exchange preliminary information needed for handover between the UE and candidate base stations over the same or a plurality of access technologies. The information includes any parameter that can affect the handover process, e.g., link quality, etc. | 11-26-2009 |
20090291686 | Autonomous connectivity between a mobile station and multiple network elements for minimizing service discontinuities during handovers in a wireless communication system - A novel and useful autonomous connectivity mechanism for use in user equipment (UE) connectivity in one or more cellular communications systems. The handover process is optimized by improving the selection of target base stations and optimizing the discontinuity period from the time of disconnection from a serving base station and connection to a target base station. The mechanism facilitates multiple cell connectivity in a network unaware manner while preserving single endpoint connectivity. The UE does not need to negotiate for or receive pre-allocated opportunities from the network for making neighboring base stations measurements. Measurement opportunities are created by the UE autonomously in accordance with UE activity patterns. Measurement opportunities are used to measure and maintain a candidate target base station list over the same or a plurality of access technologies. The parameter set tracked includes parameters that can be measured without any assistance from the target base station and which can effect the handover process, e.g., link quality, etc. | 11-26-2009 |
20100317374 | APPARATUS FOR AND METHOD OF MANAGING PAGING INTERVAL ACCESS ON A MOBILE STATION - A novel and useful apparatus for and method of managing paging availability of a mobile station in a wireless communications network. The paging availability mechanism of the present invention is able to achieve a substantial amount of power saving by modifying mobile station access to paging intervals. The mechanism dynamically controls access to the wireless network after unavailability periods when mobile stations enter into idle mode. Paging listening intervals for one or more mobile stations are scheduled and synchronized in accordance with the values of one or more parameters or metrics such as link quality. In one embodiment, this is achieved by the mobile station modifying the paging listening intervals access pattern received from the base station. Depending on the one or more parameters or metrics, one or more paging intervals may be skipped thus reducing the power consumption of the mobile station. | 12-16-2010 |
20130238857 | DEVICE, SYSTEM AND METHOD OF CONTROLLING ACCESS TO LOCATION SOURCES - Some demonstrative embodiments include devices, systems and/or methods of controlling access to location sources. For example, a device may include a location caching controller to store cached location information in a cache based on location information retrieved from two or more location sources, to receive at least one location request from at least one application, to select between retrieving requested location information from at least one of the location sources and retrieving the requested location information from the cache, and to provide to the application a location response including the requested location information. | 09-12-2013 |
20130337834 | DEVICE, SYSTEM AND METHOD OF LOCATION ESTIMATION OF A MOBILE DEVICE - Some demonstrative embodiments include devices, systems and/or methods of location estimation of a mobile device. For example, a device may include a location error corrector to provide location data to at least one application executed by the device, the location data indicating an estimated location of the device, which is based on location information from at least one location-information generator; to receive from the application error feedback information indicating an error in the estimated location; to determine a correction based on the error feedback information; and to provide to the application corrected location data based on the correction. | 12-19-2013 |
20140003542 | DEVICE, SYSTEM AND METHOD OF CLOCK DISTRIBUTION | 01-02-2014 |
20140135034 | SYSTEM AND METHOD FOR AUTONOMOUS CONNECTIVITY TO IMPROVE LOCATION-BASED INFORMATION - A wireless location information system, device, and method are directed to a plurality of location origin network transceivers (LONTs) configured to facilitate wireless communications, and provide notification information of their presence within a servicing area and a wireless device including one or more transceivers configured to transmit and receive wireless signals and a location information database configured to store location-related information. Upon the wireless device entering the area serviced by the LONTs, the wireless device detects the presence of one or more LONTs, initiates an autonomous connection request with the detected LONTs, establishes a partial association connection link with the detected LONTs, the partial association connection link being insufficient to establish full network attachment connectivity, initiates location-related information request with the LONTs, retrieves the location-related information provided by the LONTs, and stores the location-related information in the location information database. | 05-15-2014 |
20140140426 | DEVICE, SYSTEM AND METHOD OF CONTROLLING WIRELESS COMMUNICATION BASED ON AN ORIENTATION-RELATED ATTRIBUTE OF A WIRELESS COMMUNICATION DEVICE - Some demonstrative embodiments include devices, systems and/or methods of controlling wireless communication based on an orientation-related attribute of a wireless communication device. For example, a wireless communication device may include a controller to receive from a sensor orientation-related information indicating an orientation-related attribute of the wireless communication device, and to control an antenna scheme of one or more antennas of the wireless communication device based on said orientation-related information. | 05-22-2014 |
20140160951 | APPARATUS, SYSTEM AND METHOD OF SIMULTANEOUS CONNECTIVITY TO LOCATION ORIGIN TRANSCEIVERS - Some demonstrative embodiments include apparatuses, systems and/or methods of simultaneous connectivity to location origin transceivers. For example, a transceiver may be configured to simultaneously maintain a plurality of simultaneous Media-Access-Control (MAC) layer connections with a plurality of location origin beacon transceivers (LOBTs), and to communicate wireless communication signals with the plurality of LOBTs via the plurality of simultaneous MAC-layer connections. | 06-12-2014 |
20140162683 | APPARATUS, SYSTEM AND METHOD OF ESTIMATING A LOCATION OF A MOBILE DEVICE - Some demonstrative embodiments include devices, systems and/or methods of estimating a location of a mobile device. For example, a location estimation entity (LE) may be configured to receive from a server location-based location-enabling source (LES) information identifying one or more location-enabling sources based on a location area of a mobile device, and to communicate with the one or more identified location-enabling sources information for estimating the location of the mobile device. | 06-12-2014 |
20140375496 | APPARATUS, SYSTEM AND METHOD OF TIME PRESERVATION - Some demonstrative embodiments include apparatuses, systems and/or methods of time preservation. For example, an apparatus may include a time controller to preserve a time of a clock of a mobile device based on signals received by the mobile device from less than four location origin transmitters, the time controller is to determine the time based on a position of a location origin transmitter of the less than four location origin transmitters and one or more parameters relating to a transmission path between the location origin transmitter and the mobile device. | 12-25-2014 |
20150065159 | DEVICE, SYSTEM AND METHOD OF COLLABORATIVE LOCATION ERROR CORRECTION - Sonic demonstrative embodiments include devices, systems and/or methods of collaboratively correct location errors. For example, a device may include a collaborative location error corrector to collaboratively correct location errors for at least one group of two or more wireless communication devices, the location error corrector is to receive from at least a first wireless communication device of the group an error report indicating an error in an estimated location of the first wireless communication device, to determine correction information based at least on the error report from the first wireless communication device, and to provide the correction information to at least a second wireless communication device of the group. | 03-05-2015 |