Patent application number | Description | Published |
20090130228 | PHARMACEUTICAL COMBINATION FOR THE TREATMENT AND OR CHEMOSENSIBILIZATION OF REFRACTORY TUMORS TO ANTICANCER DRUGS - This invention is related to a pharmaceutical combination that contains a Casein kinase 2 (CK2) peptide inhibitor (termed P15) along with the standard chemotherapeutic drugs used in cancer treatment and which are administered together, separated or sequentially. The chemothearapeutic drugs include cisplatin, taxol, alkaloids from Vinca, 5-fluorouracil, doxorubicin, cyclophosphamide, etoposide, mitomicin C, imatinib, iressa and velcade (vortezomib). The synergism between the P15 peptide and the anticancer drugs achieves an efficient concentration of each cytostatic drug in the combination which is from 10- to 100-fold lower than that for each cytostatic drug alone. The pharmaceutical combination described in this invention exhibits lower toxicity compared to that reported by the anticancer therapeutics and therefore, it represents a crucial advantage for its use in cancer therapy. Furthermore, the sequential administration of this pharmaceutical combination through the pretreatment with the P15 peptide leads to the chemo sensibilization of refractory tumors to the anticancer therapeutics. | 05-21-2009 |
20150030700 | PHARMACEUTICAL COMBINATION FOR THE TREATMENT AND/OR CHEMOSENSIBILIZATION OF REFRACTORY TUMORS TO ANTICANCER DRUGS - This invention is related to a pharmaceutical combination that contains a Casein kinase 2 (CK2) peptide inhibitor (termed P15) along with the standard chemotherapeutic drugs used in cancer treatment and which are administered together, separated or sequentially. The chemothearapeutic drugs include cisplatin, taxol, alkaloids from Vinca, 5-fluorouracil, doxorubicin, cyclophosphamide, etoposide, mitomycin C, imatinib, iressa and velcade (bortezomib). The synergism between the P15 peptide and the anticancer drugs achieves an efficient concentration of each cytostatic drug in the combination which is from 10- to 100-fold lower than that for each cytostatic drug alone. The pharmaceutical combination described in this invention exhibits lower toxicity compared to that reported by the anticancer therapeutics and therefore, it represents a crucial advantage for its use in cancer therapy. Furthermore, the sequential administration of this pharmaceutical combination through the pretreatment with the P15 peptide leads to the chemo sensibilization of refractory tumors to the anticancer therapeutics. | 01-29-2015 |
20150111832 | PHARMACEUTICAL COMBINATION FOR THE TREATMENT AND/OR CHEMOSENSIBILIZATION OF REFRACTORY TUMORS TO ANTICANCER DRUGS - This invention is related to a pharmaceutical combination that contains a Casein kinase 2 (CK2) peptide inhibitor (termed P15) along with the standard chemotherapeutic drugs used in cancer treatment and which are administered together, separated or sequentially. The chemotherapeutic drugs include cisplatin, taxol, alkaloids from Vinca, 5-fluorouracil, doxorubicin, cyclophosphamide, etoposide, mitomycin C, imatinib, iressa, velcade (bortezomib), cytarabine (Ara C), fludarabine and mitroxantrone. The synergism between the P15 peptide and the anticancer drugs achieves an efficient concentration of each cytostatic drug in the combination which is from 10- to 100-fold lower than that for each cytostatic drug alone. The pharmaceutical combination described in this invention exhibits lower toxicity compared to that reported by the anticancer therapeutics and therefore, it represents a crucial advantage for its use in cancer therapy. Furthermore, the sequential administration of this pharmaceutical combination through the pretreatment with the P15 peptide leads to the chemo sensibilization of refractory tumors to the anticancer therapeutics. | 04-23-2015 |
Patent application number | Description | Published |
20090320991 | Methods of synthesis of nanotubes and uses thereof - The invention relates to novel methods of incorporating nanotubes for use in micro- or nano-devices. The invention further relates to incorporating nanotubes in micro or nano-devices and particularly synthesizing or growing nanotubes directly in or on components of a micro- or nano-device. In a particular embodiment, the invention relates to methods of synthesizing or growing nanotubes in a gas chromatography column and their use in portable gas chromatography devices. | 12-31-2009 |
20100213364 | SMART FAIMS SENSOR - A smart FAIMS sensor system and method includes a 2/2-electrode filter that pumps the ions through the system and separates the ionic species, a detector for collecting the separated ions and generating a detector signal in response to the collected ions, and a controller configured to change the operating parameters of the system in response to changes in the sensor's environment detected by the sensor. The ability to dynamically change the operating parameters of the sensor enables the sensor to maintain high sensitivity to environmental threats while decreasing the incidences of false positive events. | 08-26-2010 |
20110006196 | ION MOBILITY SPECTROMETER - An ion mobility spectrometer is described having an ion filter in the form of at least one ion channel having a plurality of electrodes. A time-varying electric potential applied to the conductive layers allows the filler to selectively admit ion species. The electric potential has a drive and a transverse component, and in preferred embodiments each of the electrodes is involved in generating a component of both the drive and transverse fields. The device may be used without a drift gas flow. Microfabrication techniques are described for producing microscale spectrometers, as are various uses of the spectrometer. | 01-13-2011 |
20110036973 | ION PUMP - The invention provides an ion pump to be used for selectively transferring ionised molecules across a barrier from a first volume to a second volume. The pump comprises an ion gate or filter separating the two volumes, the filter comprising at least one ion channel extending between the first and second spaces, the channel defined by a plurality of conductive layers separated along the length of the channel by at least one non-conductive layer; the device further comprising control means for applying an electric potential to the conductive layers such that the conductive layers act as electrodes. Other aspects of the invention relate to methods for selectively transferring ions. | 02-17-2011 |
20110198490 | PULSED FLOW ION MOBILITY SPECTROMETER - An ion mobility spectrometer is described which makes use of a pulsed flow pump to draw gas through an ion filter in pulsed operation. A gas counterflow may also be provided, in some embodiments this may also be a pulsed counterflow. | 08-18-2011 |
Patent application number | Description | Published |
20110320420 | Decentralized, distributed internet data management - In a light-weight transactional system architecture, each component providing a service performs its own scheduling and transaction management. An invocation of one of these services (through remote method invocation) results in the creation of a local transaction (child of the invoking transaction and parent of any transaction that might be triggered by invoking the services of other servers). The information that is required to build a global composite transaction is implicitly added by the system to each call. Each transaction is, however, independently handled at each server. That is, the servers neither communicate among themselves nor rely on a centralized component to make scheduling or recovery decisions. In this way, components can be dynamically added or removed from the system without compromising correctness. Regardless of the configuration, the system according to the invention guarantees that transactions executed over these servers are correct and recoverable at a global and local level. | 12-29-2011 |
20120197868 | Continuous Full Scan Data Store Table And Distributed Data Store Featuring Predictable Answer Time For Unpredictable Workload - A method for storing and retrieving data in a storage node of a data store and storage node of a data store, storing in main-memory at least one segment of a relational table The storage node includes at least one computational core running at least one scan thread each dedicated to the scanning of one of the at least one segment. At least one scan thread uniquely, continuously and exhaustively scans the dedicated segment of the relational table. The storage node receives and processes batches of query and update operations for the at least one segment of the relational table. The query and update operations of a batch are re-indexed at beginning of each scan by the scan thread. Then, the indexed query and update operations of a batch are independently joined to data records of said segment that match with predicates of the indexed query and update operations. | 08-02-2012 |
20130290397 | Decentralized, distributed internet data management - In a light-weight transactional system architecture, each component providing a service performs its own scheduling and transaction management. An invocation of one of these services (through remote method invocation) results in the creation of a local transaction (child of the invoking transaction and parent of any transaction that might be triggered by invoking the services of other servers). The information that is required to build a global composite transaction is implicitly added by the system to each call. Each transaction is, however, independently handled at each server. That is, the servers neither communicate among themselves nor rely on a centralized component to make scheduling or recovery decisions. In this way, components can be dynamically added or removed from the system without compromising correctness. Regardless of the configuration, the system according to the invention guarantees that transactions executed over these servers are correct and recoverable at a global and local level. | 10-31-2013 |
20150154225 | CONTINUOUS FULL SCAN DATA STORE TABLE AND DISTRIBUTED DATA STORE FEATURING PREDICTABLE ANSWER TIME FOR UNPREDICTABLE WORKLOAD - A distributed data store includes a storage layer comprised of a plurality of storage nodes, each storage node configured to receive and queue table operations, and an aggregation layer comprised of aggregator nodes configured to route table operations to storage nodes in the storage layer and merge results of table operations returned by storage nodes in the storage layer. Each storage node includes in part scan threads dedicated to continuous and full scanning of segments of a table that are respectively associated with processor cores upon which such scan threads are running. | 06-04-2015 |
Patent application number | Description | Published |
20090203912 | Regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles - The present invention relates to a process for the regioselective synthesis of compounds of the formula I, | 08-13-2009 |
20100168429 | Transition metal catalyzed synthesis of N-aminoindoles - The present invention relates to a process for the regioselective synthesis of compounds of the formula I, | 07-01-2010 |
20100216988 | Regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles - The present invention relates to a process for the regioselective synthesis of compounds of the formula I, | 08-26-2010 |
20100234601 | Transition metal catalyzed synthesis of 2H-indazoles - The present invention relates to a process for the regioselective synthesis of compounds of the formula I, | 09-16-2010 |
20100261900 | Process for the palladium-catalyzed coupling of terminal alkynes with heteroaryl tosylates and heteroaryl benzenesulfonates - A process for the palladium-catalyzed coupling of terminal alkynes with heteroaryl tosylates and heteroaryl benzenesulfonates | 10-14-2010 |
20100261909 | Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles - The present invention relates to a process for the regioselective synthesis of compounds of the formula I, | 10-14-2010 |
20140221354 | IMIDAZO [1,2-a]PYRIDINE COMPOUNDS FOR USE IN THERAPY - The present invention provides novel imidazo[1,2-a]pyridine compounds that are useful in therapy of diseases and disorders. The novel compounds inhibit the activation of Hypoxia Inducible Factor (HIF)-mediated transcription and signaling under hypoxic conditions. In one aspect, the compounds of the present invention are useful for the preparation of a medicament for the treatment or prevention of a disease or disorder selected from the group consisting of an inflammatory disease, a hyperproliferative disease or disorder, a hypoxia-related pathology and a disease characterized by excessive vascularization. Also provided is a pharmaceutical composition, comprising a compound of the invention and a second therapeutic agent or radiation, useful for the treatment or prevention of the mentioned diseases or disorders, wherein X is CH | 08-07-2014 |