Patents - stay tuned to the technology

Inventors list

Assignees list

Classification tree browser

Top 100 Inventors

Top 100 Assignees


Ali, GB

Ahmed Ali, Swansea GB

Patent application numberDescriptionPublished
20110165277Biological Materials and Uses Thereof - There is provided the use of a sandalwood extract or a sandalwood analogue as an additive to animal foodstuff for the reduction of methane production, reduction of bacterial mediated protein breakdown and reduces bacterial growth in the stomach. There are also provided food products and methods of making food products incorporating sandalwood extracts or sandalwood analogues.07-07-2011

Ahmed Yasine Ali, Morriston, Swansea GB

Patent application numberDescriptionPublished
20120177754INHIBITOR OF INFLAMMATORY CONDITIONS - The invention relates to 07-12-2012

Ayyaz Ali, Cambridge GB

Patent application numberDescriptionPublished
20150017710APPARATUS FOR TESTING, ASSESSMENT, AND MAINTENANCE OF HARVESTED HEARTS FOR TRANSPLANTING - An apparatus, a system, and methods for receiving, perfusing and maintaining and assessing excised donor heart physiological functionality, The system generally comprises an apparatus for receiving and holding an excised heart that is interconnected with: (i) a perfusate-processing system, (ii) a bi01-15-2015

Bajwa Ali, North Yorkshire GB

Patent application numberDescriptionPublished
20110301610FIXATOR - We describe fixator (12-08-2011

Faris Abed Al-Hafidh Ali, Carrickfergus GB

Patent application numberDescriptionPublished
20140273684Protective Panels - A protective panel takes the form of a cement mortar panel made of cement mortar containing metal fibres and, optionally, polymer fibres. A core volume of the panel is reinforced by a network of 3D wire cells. The network of 3D wire cells may be defined by multiple layers of metal mesh that are fixedly connected or integrated together. Such protective panels are capable of resisting fire, explosion and/or blast impact.09-18-2014

Faris Abed Al-Hafidh Ali, Carrickfergus, Antrim GB

Patent application numberDescriptionPublished
20150316358Smart Blast Sensing - An automated smart system for forming a blast resistant structure comprises one or more remote blast sensors connected to at least one actuator arranged to actively deform a panel of the structure from an initial configuration to a curved configuration in response to sensing a blast.11-05-2015

Ghazanfer Ali, Reading Berkshire GB

Patent application numberDescriptionPublished
20090057920LOW-NOISE FLIP-CHIP PACKAGES AND FLIP CHIPS THEREOF - A low-noise flip-chip package, comprising: a carrier substrate having first and second opposing main faces; and a flip-chip substrate connected in a face-down manner onto the first main face of the carrier substrate via a connection array, wherein: the flip-chip substrate comprises at least first and second circuitry portions spaced apart from one another; the flip-chip substrate comprises a substrate-contact boundary located between the first and second circuitry portions; and each of the first circuitry portion, the second circuitry portion and the substrate-contact boundary has its own separate signal-reference connection extending via a respective connection of the connection array through the carrier substrate to a respective electrical contact at the second main face of the carrier substrate for connection to a common signal-reference element in an external circuit.03-05-2009
20120106094LOW-NOISE FLIP-CHIP PACKAGES AND FLIP CHIPS THEREOF - A low-noise flip-chip package, comprising: a carrier substrate having first and second opposing main faces; and a flip-chip substrate connected in a face-down manner onto the first main face of the carrier substrate via a connection array, wherein: the flip-chip substrate comprises at least first and second circuitry portions spaced apart from one another; the flip-chip substrate comprises a substrate-contact boundary located between the first and second circuitry portions; and each of the first circuitry portion, the second circuitry portion and the substrate-contact boundary has its own separate signal-reference connection extending via a respective connection of the connection array through the carrier substrate to a respective electrical contact at the second main face of the carrier substrate for connection to a common signal-reference element in an external circuit.05-03-2012
20120187579LOW NOISE FLIP-CHIP PACKAGES AND FLIP CHIPS THEREOF - A flip chip comprises first and second circuitry portions formed in a substrate. The first and second circuitry portions are spaced apart from one another in a separation direction. A substrate-contact boundary is formed in the substrate between the first and second circuitry portions.07-26-2012
20120326335LOW-NOISE FLIP-CHIP PACKAGES AND FLIP CHIPS THEREOF - A low-noise flip-chip package, comprising: a carrier substrate having first and second opposing main faces; and a flip-chip substrate connected in a face-down manner onto the first main face of the carrier substrate via a connection array, wherein: the flip-chip substrate comprises at least first and second circuitry portions spaced apart from one another; the flip-chip substrate comprises a substrate-contact boundary located between the first and second circuitry portions; and each of the first circuitry portion, the second circuitry portion and the substrate-contact boundary has its own separate signal-reference connection extending via a respective connection of the connection array through the carrier substrate to a respective electrical contact at the second main face of the carrier substrate for connection to a common signal-reference element in an external circuit.12-27-2012
20140124930LOW-NOISE FLIP-CHIP PACKAGES AND FLIP CHIPS THEREOF - A low-noise flip-chip package, comprising: a carrier substrate having first and second opposing main faces; and a flip-chip substrate connected in a face-down manner onto the first main face of the carrier substrate via a connection array, wherein: the flip-chip substrate comprises at least first and second circuitry portions spaced apart from one another; the flip-chip substrate comprises a substrate-contact boundary located between the first and second circuitry portions; and each of the first circuitry portion, the second circuitry portion and the substrate-contact boundary has its own separate signal-reference connection extending via a respective connection of the connection array through the carrier substrate to a respective electrical contact at the second main face of the carrier substrate for connection to a common signal-reference element in an external circuit.05-08-2014

Patent applications by Ghazanfer Ali, Reading Berkshire GB

Hanif Ali, Cambridge GB

Patent application numberDescriptionPublished
20150079680METHODS, CELLS & ORGANISMS - The invention relates to an approach for introducing one or more desired insertions and/or deletions of known sizes into one or more predefined locations in a nucleic acid (eg, in a cell or organism genome). They developed techniques to do this either in a sequential fashion or by inserting a discrete DNA fragment of defined size into the genome precisely in a predefined location or carrying out a discrete deletion of a defined size at a precise location. The technique is based on the observation that DNA single-stranded breaks are preferentially repaired through the HDR pathway, and this reduces the chances of indels (eg, produced by NHEJ) in the present invention and thus is more efficient than prior art techniques. The invention also provides sequential insertion and/or deletions using single- or double-stranded DNA cutting.03-19-2015
20150133641TRANSGENIC NON-HUMAN VERTEBRATE FOR THE IN VIVO PRODUCTION OF DUAL SPECIFICITY IMMUNOGLOBULINS OR HYPERMUTATED HEAVY CHAIN ONLY IMMUNOGLOBULINS - The invention relates, in one aspect, generally to novel concept of guided selection of antibody variable domains, combination and expression entirely in vivo. An application is to produce multivalent polypeptides. The present invention relates to multivalent (eg, multispecific) antibodies, antibody chains and polypeptides, as well as heavy chain-only antibodies (H2 antibodies) that are devoid of light chains. The invention further relates to the selection, maturation and production of these in vivo in non-human vertebrates and non-human vertebrate cells. To this end the invention also relates to such non-human vertebrates and cells. The invention also relates to the provision of means to produce and select heavy chain-only antibodies and heavy chains comprising variable domains that have undergone affinity maturation.05-14-2015

Hussain Ali, London GB

Patent application numberDescriptionPublished
20140328951Composition for Preventing and Treating Vision Deterioration and Age-Related Macular Degeneration through Retinal Repair Using Ginseng/Red Ginseng Extracts and Ginsenoside - The present invention provides a composition comprising ginseng extract, red ginseng extract or ginsenosides as active ingredients for the prevention, slowed progression, and treatment of macular degeneration. More specifically it provides pharmaceutical composition to improve visual function by regenerating the transport characteristics of Bruch's membrane.11-06-2014

Isaac Ali, Bristol GB

Patent application numberDescriptionPublished
20090085660AGC MODULE AND METHOD FOR CONTROLLING NOISE FIGURE AND INTERMODULATION CHARACTERISTICS THEREIN - An Automatic Gain Control (AGC) module for controlling Noise Figure (NF) and IM characteristics therein is disclosed. The AGC module comprises a plurality of AGC stages. Each AGC stage comprises a differential amplifier circuit, an input signal transistor and a current-steering circuit. Differential amplifier circuits of the plurality of AGC stages receive control signals at their differential inputs and their output is connected to a common load. The input signal transistors of the plurality of AGC stages receive a common input signal and is further coupled to the differential amplifier circuit and the current-steering circuit. The current-steering circuits and the control signals at the differential amplifier circuits control gain of the each AGC stage of the plurality of AGC stage, which is used to control the NF and the IM characteristics.04-02-2009
20100323636Apparatus and methods for implementing multi-channel tuners - Embodiments of systems and methods for implementing multi-channel tuners are generally described herein. Other embodiments may be described and claimed.12-23-2010
20100330932Apparatus and methods for efficient implementation of tuners - Embodiments of systems and methods for the efficient implementation of tuners are generally described herein. Other embodiments may be described and claimed.12-30-2010
20110019785Alignment of channel filters for multiple-tuner apparatuses - Apparatuses, systems, and methods that align channel filters for dual tuners are disclosed. An embodiment may comprise an IC having two tuners. Each tuner may have a low-noise amplifier, a mixer with a local oscillator, and channel filter. To perform a channel filter alignment, a bandwidth controller may cross-couple the local oscillator of each tuner to the input of the mixer of the opposite tuner. The bandwidth controller may adjust the frequencies of the local oscillators to produce different configuration tone frequencies at the outputs of the mixers, which are inputs to the channel filters. The bandwidth controller may then determine an amplitude difference between two separate measurements of a channel filter output and, based on a comparison of the measurements with predicted values, increment or decrement the filter bandwidth for each tuner and store parameters for the channel filters which create the largest signal amplitudes.01-27-2011
20110069744METHODS AND SYSTEMS TO COMPENSATE IQ IMBALANCE IN WIDEBAND ZERO-IF TUNERS - Methods and systems to compensate IQ imbalances in a tuner system, including relatively wideband ZIF tuner systems and tuner systems having substantially linear frequency dependent phase imbalance, where a one-tap compensation element may be utilized to compensate frequency dependent phase imbalance. A two tone probe may be applied in controlled loop-back modes, and resultant baseband components may be used to determine a straight line from which to determine compensation. The probe may include a Multi-Media over Coax Alliance (MoCA) Type 2 probe. Compensation parameters may be determined as fixed or non-adaptive compensation parameters in a digital domain and may be applied at baseband. One or more compensation values may be determined in a fixed point circuit.03-24-2011
20110075034METHOD AND APPARATUS TO SUPPORT MULTI-CHANNEL RECEPTION - In accordance with various aspects of the disclosure, a method and apparatus for receiving multiple channels from a broadcast source and interfacing to multiple demodulators within a common silicon implementation is disclosed. A receiver apparatus is disclosed that may aggregate multiple channels output by multiple tuners into at least one composite signal. The at least one composite signal may be passed to a single ADC. The channels may then be extracted from the at least one composite signal in the digital domain prior to demodulation in separate demodulators.03-31-2011
20110149171Efficient tuning and demodulation techniques - Techniques for the reception and processing of wireless signals are disclosed. For instance, an apparatus may include multiple receiving paths, a content stream generation module, and a distribution module. The multiple receiving paths include a first receiving path that generates a first decoded signal from an input RF signal in accordance with a first tuning setting. The content stream generation module has first and second inputs. Based on decoded signals received at the first and second inputs, the content stream generation module may generate first and second content streams, respectively. In situations where both the first and second content streams correspond to the first tuning setting, the distribution module provides the first decoded signal to both the first and second inputs of the content stream generation module. Also, a control module may remove operational power from any of the plurality of receiving paths that are currently being unused.06-23-2011
20110151818CORRECTING QUADRATURE CROSSTALK CONTAMINATION IN RECEIVERS - An apparatus, a method and a system for correcting a phase imbalance are described. Embodiments may measure the phase imbalance inherent in a tuner and use the imbalance measure to correct the output of the tuner. Embodiments may include a tone generator to produce a single frequency tone and a tuner to receive the single frequency tone and output an intermediate frequency. The intermediate frequency may be corrected by a correction loop. Other embodiments are described and claimed.06-23-2011
20110293043DC OFFSET CORRECTION TECHNIQUES - Techniques are disclosed that involve the reduction of DC offsets. For instance, embodiments may receive a baseband signal, and determine a DC characteristic of the baseband signal. When the DC characteristic has a value that is outside of a predetermined range, a correction signal is adjusted. The correction signal is injected into the baseband signal.12-01-2011
20110293048Quadrature gain and phase imbalance correction - Generally speaking, methods and apparatuses which correct errors related to phase and gain imbalances in quadrature tuners are disclosed. The quadrature tuner may be online and operating, receiving data. An embodiment may generate a squared signal from the IF frequency signal of the tuner. In generating the squared signal, the embodiment may enable the extraction of phase error and gain error information of the IF signal. The embodiment may determine a phase error component, a gain error component, or both, by frequency translation. The frequency translation may involve down-converting the signal associated with the error component to direct current (DC) signals and enable the determination of the associated phase error and/or gain error. The embodiments may generate an adjusted signal via the IF signal by applying a phase correction signal or gain correction signal to components used to correct the IF signal.12-01-2011
20120076191Apparatus and method to process signals from one or more transmission sources - A receiver and a method to process signals from one or more transmission sources. The receives includes a front-end having: an input coupling path to route an analog input signal received from one or more transmission sources; an equalizer to generate an equalized signal from the analog input signal; and an ADC to generate a digitized signal from the equalized signal. The method includes routing the analog input signal through an input coupling path; equalizing the analog input signal to generate an equalized signal therefrom; and digitizing the equalized signal to generate a digitized signal therefrom.03-29-2012
20120249107COUPLED INDUCTOR TO FACILITATE INTEGRATED POWER DELIVERY - An embodiment of the present invention provides an apparatus, comprising a surface mounted device (SMD) inductor, the SMD inductor including at least two counter wound aircoils formed on a same SMD former; wherein the at least two counter wound aircoils are connected to three terminals on the SMD former, wherein a single terminal is connected to a common node of both windings with two independent terminals accessing the other winding node.10-04-2012
20130154732POWER MANAGEMENT IN TRANSCEIVERS - Various embodiments are directed to apparatuses and methods to reduce average power dissipation in transceiver stages such as power amplifiers and low noise amplifiers (LNAs) that process signals of varying output amplitudes. Power dissipation may be reduced by varying the supply voltage in sympathy with the amplitude of the signal and/or the stage current density which may also be varied in sympathy with the signal amplitude.06-20-2013
20130157482DECOUPLING ARRANGEMENT - In various embodiments, apparatuses and methods are disclosed that may be able to implement a multi-layer, three dimensional routing between a decoupling component and an input port for a SoC or MCM. A three dimensional (3D) structure may provide a defined current return path from the decoupling component to the input port. The current return path may be constrained by design to provide an equal and opposite electromagnetic flux to the input port thereby reducing series inductance between the input port and the decoupling component.06-20-2013
20140091958METHODS AND ARRANGEMENTS FOR HIGH-SPEED DIGITAL-TO-ANALOG CONVERSION - Embodiments may comprise logic such as hardware and/or code for high-speed digital-to-analog conversion of signals. Many embodiments comprise a demultiplexer to distribute sets of bits to digital-to-analog converters, the digital-to-analog converters to receive the sets of bits and the operate concurrently to convert the sets of bits from digital representations of signal segments to output analog signal segments, and an interleaver to interleave the analog signal segments from each of digital-to-analog converters in the sequence to generate an analog signal. In many embodiments, the interleaver is adapted to interleave the analog signal segments by latching magnitudes of each of the analog signal segments to an interleaved output near ends of clock cycles to attenuate non-linearities in the magnitudes of each of the analog signal segments when the magnitudes are output.04-03-2014
20140091960METHODS AND ARRANGEMENTS FOR HIGH-SPEED ANALOG-TO-DIGITAL CONVERSION - Logic such as hardware and/or code for high-speed analog-to-digital conversion of a signal. Logic may receive an analog signal as an input to a sampling receiver. The sampling receiver may implement a successive approximation register (SAR), analog-to-digital converter (ADC) to produce the digital output. Logic may re-task a comparator of the SAR ADC during a sampling mode to generate a digital comparator output that represents a comparison of a voltage of the charge on a capacitance of the DAC against a threshold reference voltage. The digital comparator output may be applied to the input of automatic gain control (AGC) logic. The AGC logic may receive the digital comparator signal which is representative of one sample of a multiple sample, sample cycle, allowing the AGC logic to generate a gain control signal that is responsive to both total composite average and peak amplitudes.04-03-2014
20150035507DUAL MODE VOLTAGE REGULATOR WITH DYNAMIC RECONFIGURATION CAPABILITY - A dual mode voltage regulator according to one embodiment includes a passive regulator circuit; a switching regulator circuit; and a controller circuit configured to monitor operational parameters of the dual mode voltage regulator and selectively couple either the passive regulator circuit or the switching regulator circuit between an input voltage port and an output load. The selective coupling is based on the monitoring of parameters including current through the output load, voltage at the input voltage port and voltage at the output load as well as the availability of a system clock signal.02-05-2015
20150131190DECOUPLING ARRANGEMENT - In various embodiments, apparatuses and methods are disclosed that may be able to implement a multi-layer, three dimensional routing between a decoupling component and an input port for a SoC or MCM. A three dimensional (3D) structure may provide a defined current return path from the decoupling component to the input port. The current return path may be constrained by design to provide an equal and opposite electromagnetic flux to the input port thereby reducing series inductance between the input port and the decoupling component.05-14-2015
20150295550POWER MANAGEMENT IN TRANSCEIVERS - Various embodiments are directed to apparatuses and methods to generate a first signal representing modulation data and a second signal representing an amplitude of the modulation data, the first signal and the second signal to depend on an output signal and vary a power supply voltage to a gain stage in proportion to the amplitude of the modulation data.10-15-2015

Patent applications by Isaac Ali, Bristol GB

Isaac Ali, Berkshire GB

Patent application numberDescriptionPublished
20150042295DUAL MODE VOLTAGE REGULATOR WITH RECONFIGURATION CAPABILITY - A dual mode voltage regulator according to one embodiment includes a passive regulator circuit, a switching regulator circuit, and a controller circuit configured to determine parameters of an external select input. The controller is configured to selectively couple, on a cold boot up, either the passive regulator circuit or the switching regulator circuit between an input voltage port and an output load based on the determination of parameters.02-12-2015

Khadija Ali, London GB

Patent application numberDescriptionPublished
20130111670Baby Support Arrangement - A device for supporting an infant, the device comprising: a support arrangement and a holding arrangement, the support arrangement being configured to support the holding arrangement at a distance above a surface on which the support arrangement rests, the holding arrangement having a main aperture formed there through and a first engagement arrangement; and first and second inserts that may be interchangeably engaged with the holding arrangement, herein when each of the inserts is engaged with the first engagement arrangement, the legs of the infant may pass through the main aperture and the weight of the infant may be substantially supported by the insert.05-09-2013

Mezher Hussein Ali, Berkshire GB

Patent application numberDescriptionPublished
20080220005Comb Polymers - The present invention provides a process for producing a comb polymer comprising the steps of: a) providing: (i) (w+z) molar equivalents of a monomer; (ii) one molar equivalent of an initiator compound of formula (IX), wherein B09-11-2008

Mezher Hussein Ali, Slough GB

Patent application numberDescriptionPublished
20130296338Quinoline and Quinoxaline Derivatives as Kinase Inhibitors - A series of quinoline and quinoxaline derivatives comprising a fluorinated ethyl side-chain, being selective inhibitors of P13 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.11-07-2013

Mohammad Tareq Bin Ali, Huddersfield GB

Patent application numberDescriptionPublished
20140311245PIPE INSPECTION SYSTEM AND RELATED METHODS - The present invention provides an improved pipe inspection system and related methods. In one embodiment, the invention provides an airbourne acoustic pipe inspection system and method. The present invention further comprises a non-transitory computer-readable medium storing executable computer program code for inspecting pipes.10-23-2014

Mohammed Yaseen Ali, West Midlands GB

Patent application numberDescriptionPublished
20100235696EMBEDDED TEST SYSTEM AND METHOD - An embedded test system is provided where asynchronous communications links are used to pass the boundary scan information by the use of a network router to a boundary scan adapter (09-16-2010

Peter Kalam Ali, London GB

Patent application numberDescriptionPublished
20130014334CLEANING DEVICE WITH CLEANING PADAANM Ali; Peter KalamAACI LondonAACO GBAAGP Ali; Peter Kalam London GBAANM Yates; Russell PeterAACI LondonAACO GBAAGP Yates; Russell Peter London GBAANM Yates; Francis EdzardAACI LondonAACO GBAAGP Yates; Francis Edzard London GB - A cleaning device (01-17-2013

Rana Ali, Berkshire GB

Patent application numberDescriptionPublished
20130072408USES AND COMPOSITIONS - The use of an oil-soluble mono-, di-, or tri-glyceride of at least one hydroxy polycarboxylic acid, or a derivative thereof, as an anti-wear additive and/or friction modifier in a non-aqueous lubricant composition and/or in a fuel composition. Also, a non-aqueous lubricant composition and a fuel composition for an internal combustion engine which comprise at least one additive which is an oil-soluble mono-, di-, or tri-glyceride of at least one hydroxy polycarboxylic acid, or a derivative thereof.03-21-2013

Robin R. Ali, London GB

Patent application numberDescriptionPublished
20100081707DEVICES AND METHODS FOR DELIVERING POLYNUCLEOTIDES INTO RETINAL CELLS OF THE MACULA AND FOVEA - Methods and systems for the delivery of polynucleotides to the subretinal space of the macula or fovea of an eye of a human are provided. The methods and systems are useful for treating ocular disorders.04-01-2010

Saad Ali, York GB

Patent application numberDescriptionPublished
20100040662Fixation Devices For Tissue Repair - Fixation devices for tissue repair, for example sutures, surgical arrows, staples, darts, bolts, screws, buttons, anchors, nails, rivets, or barbed devices comprise at least one of angiogenic material; angiogenic precursor material which is capable of breaking down in vivo to form angiogenic material; or tissue-engineered material, which tissue-engineered material is capable of producing angiogenic material. In a preferred form, the material is incorporated into a polymer matrix having predetermined hydrophobicity to allow controlled release of angiogenic materials such as butyric or hydroxybutyric acid or salts thereof. Polymer matrix compositions comprising angiogenic materials and methods for tissue repair are also provided.02-18-2010

Saad Abdul Majeed Ali, Leeds GB

Patent application numberDescriptionPublished
20140370100BONE FILLER COMPOSITION - A bone filler composition comprises a mixture of a curable calcium phosphate based bone filler which is formed from a liquid component and a calcium phosphate based powder component, and a formulation which comprises a bisphosphonate in particulate form. The particles of the bisphosphonate being embedded in particles of a polymeric material which resorbs when the formulation is implanted.12-18-2014

Shahena Ali, Stanford-Le-Hope GB

Patent application numberDescriptionPublished
20120301410COSMETIC - A cosmetic for application to skin, the cosmetic comprising a base matrix to coat a skin surface as a wet covering to present a pheromone component within for contact transfer release with or without the base matrix.11-29-2012

Simak Ali, London GB

Patent application numberDescriptionPublished
20090082250Control of gene expression using a complex of an oligonucleotide and a regulatory peptide - A method for suppressing the expression of a selected gene in a cell the method comprising introducing into the cell a molecule comprising (1) a nucleic acid binding portion which binds to a site or associated with the selected gene which site is present in a genome and (2) an expression repressor portion, wherein the nucleic acid binding portion comprises an oligonucleotide or oligonucleotide mimic or analogue, and wherein the repressor portion comprises a polypeptide or peptidomimetic. Molecules for use in the methods of the invention are provided. The repressor may be a portion of a histone deacetylase or DNA methylase or polypeptide capable of recruiting a histone deacetylase or DNA methylase.03-26-2009
20100261683Selective Inhibitors for Cyclin-Dependent Kinases - This invention provides a class of compounds which are useful for specifically inhibiting cyclin-dependent kinases. This class of compounds finds use in treating diseases resulting from inappropriate activity of cyclin-dependent kinases, including cancer, viral infections (e.g., HIV) neurodegenerative disorders (e.g. Alzheimer's disease), and cardiovascular disorders (e.g. atherosclerosis). Moreover, certain members of this class are particularly useful for inhibiting cyclin-dependent kinase 7 and are especially useful for the treatment of breast cancer.10-14-2010
20110189669METHODS OF AIDING IN THE DIAGNOSIS OF PROSTATE CANCER - The current invention provides a method for aiding in the assessment of prostate cancer (including metastatic prostate cancer) and/or benign prostate hyperplasia in a patient, wherein the method comprises the step of determining the level of Glycine N-methyltransferase (GNMT) nucleic acid and/or protein in a sample from the patient. The invention also provides compounds that target Glycine N-methyltransferase (GNMT) protein and/or nucleic acid for use in treating prostate cancer. Also provided are screening methods for selecting a compound considered to be useful in treating prostate cancer, comprising the steps of determining the ability of a test compound to reduce GNMT activity and selecting a compound that reduces GNMT activity. The invention also provides methods for aiding in the diagnosis of prostate cancer in a patient comprising obtaining a sample from the patient and assessing said sample for a marker of GNMT activity.08-04-2011
20120077270Control of Gene Expression Using a Complex of an Oligonucleotide and a Regulatory Peptide - A method for suppressing the expression of a selected gene in a cell, the method comprising introducing into the cell a molecule comprising (1) a nucleic acid binding portion which binds to a site or associated with the selected gene which site is present in a genome and (2) an expression repressor portion, wherein the nucleic acid binding portion comprises an oligonucleotide or oligonucleotide mimic or analogue, and wherein the repressor portion comprises a polypeptide or peptidomimetic. Molecules for use in the methods of the invention are provided. The repressor may be a portion of a histone deacetylase or DNA methylase or polypeptide capable of recruiting a histone deacetylase or DNA methylase.03-29-2012

Patent applications by Simak Ali, London GB

Simi Ali, Newcastle Upon Tyne GB

Patent application numberDescriptionPublished
20100298203SDF-I-BASED GLYCOSAMINOGLYCAN ANTAGONISTS AND METHODS OF USING SAME - The present invention relates to novel mutants of human stromal cell-derived factor-1 which exhibit increased glycosaminoglycan (GAG) binding affinity and inhibited or down-regulated GPCR activity compared to wild type SDF-1, methods for producing these mutants and to their use for preparing medicaments for the treatment of cancer.11-25-2010

Syed Zeeshan Ali, Cambridge GB

Patent application numberDescriptionPublished
20110174799MICRO-HOTPLATES - A micro-hotplate is provided in the form of a device comprising a sensor and one or more resistive heaters within the micro-hotplate arranged to heat the sensor. Furthermore a controller is provided for applying a bidirectional drive current to at least one of the heaters to reduce electromigration. The controller also serves to drive the heater at a substantially constant temperature. Such an arrangement is advantageous over an arrangement in which a unidirectional DC drive current is applied to the heater. This is because the unidirectional drive current causes electromigration which results in an increase in resistance over time. This is undesirable because it can lead to failure of the micro-hotplate. In contrast, the application of the bidirectional current reduces electromigration and as a result there is insignificant change in the resistance of the heater over time and under high temperature. This in turn improves the reliability of the micro-hotplate and therefore helps to improve the lifetime of the sensor07-21-2011
20120267532IR EMITTER AND NDIR SENSOR - An IR source in the form of a micro-hotplate device including a CMOS metal layer made of at least one layer of embedded on a dielectric membrane supported by a silicon substrate. The device is formed in a CMOS process followed by a back etching step. The IR source also can be in the form of an array of small membranes—closely packed as a result of the use of the deep reactive ion etching technique and having better mechanical stability due to the small size of each membrane while maintaining the same total IR emission level. SOI technology can be used to allow high ambient temperature and allow the integration of a temperature sensor, preferably in the form of a diode or a bipolar transistor right below the IR source.10-25-2012

Syed Zeeshan Ali, Cambridgeshire GB

Patent application numberDescriptionPublished
20140291704PLASMONIC IR DEVICES - An infra-red (IR) device comprising a dielectric membrane formed on a silicon substrate comprising an etched portion; and at least one patterned layer formed within or on the dielectric membrane for controlling IR emission or IR absorption of the IR device, wherein the at least one patterned layer comprises laterally spaced structures.10-02-2014

Zaki Ali, Enfield GB

Patent application numberDescriptionPublished
20140180658MODEL-DRIVEN SURVEILLANCE AND DIAGNOSTICS - Performing diagnostic of hydrocarbon production in a field includes generating a thermal-hydraulic production system model of a wellsite and a surface facility in the field, and simulating, using the thermal-hydraulic production system model, and based on multiple root causes, a hydrocarbon production problem to generate a feature vectors corresponding to the root causes. Each of feature vectors includes parameter values corresponding to physical parameters associated with the hydrocarbon production. Performing diagnostic further includes configuring, using the feature vectors, a classifier of the hydrocarbon production problem, detecting the hydrocarbon production problem in the field, analyzing, using the classifier, and in response to detecting the hydrocarbon production problem, surveillance data from the wellsite and the surface facility to identify a root cause, and presenting the root cause to a user. The classifier is configured to classify the hydrocarbon production problem according to the root causes.06-26-2014

Zulfiqur Ali, Stokesley GB

Patent application numberDescriptionPublished
20100141951DETECTION METHOD - The invention relates to an apparatus and method for the detection of the spectral absorption properties of a fluid in a microenvironment, the apparatus comprising a radiation source, a microfluidic device and detection means, wherein the apparatus additionally comprises means for increasing the path length of the radiation through the fluid. Preferably, the means for increasing the path length of the radiation through the fluid comprises two highly reflective mirrors which cause the base path length through the fluid to be increased by many orders of magnitude, and the method comprises Cavity Enhanced Absorption Spectroscopy. The method is especially useful for the handling of small volumes of fluids for chemical and biological processing.06-10-2010
Website © 2015 Advameg, Inc.