Patent application number | Description | Published |
20090221466 | FLUORINATED SURFACTANTS - A composition of formula I | 09-03-2009 |
20110009668 | POLYFLUOROSULFONAMIDO AMINE AND INTERMEDIATE - Current methods for making polyfluorosulfonamido amines, which involve the use of a diamine reactant, provide low yields and produce an undesirable fluorine containing bis-sulfonamide by-product representing an economic loss. The bis-sulfonamide by-product is particularly undesirable because it shares very similar physical properties with the desired monoamine product thus making isolation of the desired polyfluorosulfonamido amine product difficult and costly. Furthermore, instead of the efficient incorporation of fluorine to make the desired polyfluorosulfonamido amine product, the bis-sulfonamide by-product constitutes a substantial loss of costly fluorinated starting material. The bis-sulfonamide by-product also constitutes an undesirable impurity that can worsen surfactancy, repellency, or other performance characteristics of the desired polyfluorosulfonamido amine product. The present invention provides a method of making a polyfluorosulfonamido amine without the production of a bis-sulfonamide by-product by reacting a polyfluoroalkylsulfonic compound with a monoamino amide rather than with a diamine reactant as in previously known methods. | 01-13-2011 |
20110232924 | SURFACTANT COMPOSITION FROM POLYFLUOROALKYLSULFONAMIDO ALKYL AMINES - The present invention relates to aminosulfonate and aminocarboxylate compositions derived from a mixture of polyfluoroalkylsulfonamido alkyl amines including at least one polyfluoroalkylsulfonamido alkyl amine and its analog, a di(polyfluoroalkylsulfonamido alkyl) amine. The aminosulfonate and aminocarboxylate compositions are useful for many purposes including amphoteric surface-active agents and aqueous film forming foams in fire fighting applications. | 09-29-2011 |
20110233459 | MIXTURE OF POLYFLUOROALKYLSULFONAMIDO ALKYL AMINES - The present invention relates to a mixture of polyfluoroalkylsulfonamido alkyl amines including at least one polyfluoroalkylsulfonamido alkyl amine and its analog, a di(polyfluoroalkylsulfonamido alkyl) amine. The invention also relates to polyfluoroalkylsulfonamido alkyl halide intermediate used to make the aforementioned mixture. | 09-29-2011 |
20110237834 | POLYFLUOROALKYLSULFONAMIDO ALKYL HALIDE INTERMEDIATE - The present invention relates to a polyfluoroalkylsulfonamido alkyl halide intermediate. The invention also relates to the use of the aforementioned halide intermediate to prepare a mixture of polyfluoroalkylsulfonamido alkyl amines including at least one polyfluoroalkylsulfonamido alkyl amine and its analog, a di(polyfluoroalkylsulfonamido alkyl) amine. | 09-29-2011 |
20130284048 | FLUORINATED SURFACTANTS - A composition of formula I | 10-31-2013 |
20140024855 | PROCESS TO PRODUCE FLUORINATED BETAINES - A process to prepare fluorinated sulfobetaine compounds of formula (I) | 01-23-2014 |
Patent application number | Description | Published |
20110257081 | MULTIGAND CONSTRUCTS - Multiligand constructs and intermediate multivalent constructs for use in their preparation are described. The multiligand constructs have utility in diagnostic and therapeutic applications. | 10-20-2011 |
20120021430 | FUNCTIONAL LIPID CONSTRUCTS - The invention relates to methods for effecting qualitative and quantitative changes in the functional moieties expressed at the surface of cells and multi-cellular structures, and functional lipid constructs for use in such methods. In particular, the invention relates to functional lipid constructs and their use in diagnostic and therapeutic applications, including serodiagnosis, where the functional moiety is a carbohydrate, peptide, chemically reactive group, conjugator or fluorophore. | 01-26-2012 |
20140135477 | MULTILIGAND CONSTRUCTS - Multiligand constructs and intermediate multivalent constructs for use in their preparation are described. The multiligand constructs have utility in diagnostic and therapeutic applications. | 05-15-2014 |
20140161723 | IN VIVO METHODS OF MONITORING BIODISTRIBUTION - Functional-lipid constructs of the structure F-S-L are disclosed, wherein F comprises a tyrosine or histidine residue, S is a spacer covalently linking F to L and L is a lipid. The functional residue may be iodinated and used to radiolabel a biological entity with 1251 and the iodinated constructs are used in a non-invasive method of monitoring the distribution of a biological entity in vivo. | 06-12-2014 |
20140350217 | FUNCTIONAL LIPID CONSTRUCTS - The invention relates to methods for effecting qualitative and quantitative changes in the functional moieties expressed at the surface of cells and multi-cellular structures, and functional lipid constructs for use in such methods. In particular, the invention relates to functional lipid constructs and their use in diagnostic and therapeutic applications, including serodiagnosis, where the functional moiety is a carbohydrate, peptide, chemically reactive group, conjugator or fluorophore. | 11-27-2014 |
Patent application number | Description | Published |
20080228204 | Limited Access Suturing Devices, System, and Methods - Medical suturing devices, systems, and methods will be useful for endoscopic (with or without access ports) or other surgeries in which access is limited, including ear, nose, and throat procedures. Articulation motions may be transferred from a handle to needle grasping jaws using an axial movement of a shaft that has axial stiffness (such as being stiff in compression) and lateral flexibility or an axial movement of a cable. An extension body (within which the shaft or cable moves) between the handle and jaws can be pre-bent or custom bent by the user. Portions of the devices may be disposable, replaceable, and/or reusable. A spring adjacent the clamp may open the clamp or impose a gripping force. | 09-18-2008 |
20080243147 | Replaceable Tip Suturing Devices, System, and Methods for Use with Differing Needles - Medical suturing devices, systems, and methods will be useful for endoscopic or open surgeries, including ear, nose, and throat procedures. Articulation motions may be transferred from a handle to needle grasping jaws using an axial movement of a shaft. Portions of the devices may be disposable, replaceable, and/or reusable, with different needle-grasping jaws and/or different elongate extension bodies having different configurations optionally being selectably coupleably to an articulatable handle and housing so as to allow the user to configure the device for a particular procedure. | 10-02-2008 |
20100268257 | SUTURING DEVICE, SYSTEM, AND METHOD - Improved medical suturing devices, systems, and methods may hold a suture needle at a fixed location relative to a handle of the device, allowing the surgeon to grasp and manipulate the handle of the suturing device to insert the needle through tissues in a manner analogous to use of a standard needle gripper. Cycling the handle from a closed position to an open position and back to the closed position may alternate the device between gripping the needle with a first clamp (for example, along a proximal portion of the needle) to gripping the needle with a second clamp (for example, along a distal portion of the needle) and optionally back to gripping with the first clamp, with the needle often staying at a substantially fixed location relative to the suturing device body. Related single-clamp needle grasping devices can be bent plastically by a surgeon, and/or have bodies that are grasped by a hand while a portion of the hand actuates a handle. | 10-21-2010 |
20110251627 | Suturing Device, System, and Method - Improved medical suturing devices, systems, and methods may hold a suture needle at a fixed location relative to a handle of the device, allowing the surgeon to grasp and manipulate the handle of the suturing device to insert the needle through tissues in a manner analogous to use of a standard needle gripper. Cycling the handle from a closed position to an open position and back to the closed position may alternate the device between gripping the needle with a first clamp (for example, along a proximal portion of the needle) to gripping the needle with a second clamp (for example, along a distal portion of the needle) and optionally back to gripping with the first clamp, with the needle often staying at a substantially fixed location relative to the suturing device body. Related single-clamp needle grasping devices can be bent plastically by a surgeon, and/or have bodies that are grasped by a hand while a portion of the hand actuates a handle. | 10-13-2011 |
20120165837 | Endoscopic Suturing Device, System and Method - Improved medical suturing devices, systems, and methods may hold a suture needle at a fixed location relative to a handle of the device, allowing a surgeon to grasp and manipulate the handle of the suturing device to insert the needle through tissues. The exemplary device includes two needle grasping clamps extending from an elongate distal portion for endoscopic surgeries, including ear, nose and throat procedures. The two clamps alternate holding the suture needle, as the surgeon sutures the tissues, each clamp having a proximal and distal gripping jaw for grasping the needle. Preferably, the gripping surfaces of the proximal and distal gripping jaws are substantially parallel to the needle's plane of curvature and exert a holding force on the needle substantially along an axis of the device. | 06-28-2012 |
20120316580 | OFFSET JAW SUTURING DEVICE, SYSTEM, AND METHODS - Improved medical suturing devices, systems, and methods for maintaining a position and orientation of a suture needle at a fixed location relative to a suturing device. An exemplary device include a clamp having opposing grasping surfaces for grasping the needle at a first location, and a needle contacting surface for contacting the needle at a second location, the second location a distance axially away from the first location so as to inhibit unintended movement of the needle relative to the device, which may include rotation of the needle about the first location and rotation of the needle about its axis. In many embodiments, the device includes a first and second clamp and a mechanism for alternating grasping of the needle between the first and second clamp. The device may also be incorporated into a single-clamp needle grasping device. | 12-13-2012 |
20130060262 | LIMITED ACCESS SUTURING DEVICES, SYSTEM, AND METHODS - Medical suturing devices, systems, and methods will be useful for endoscopic (with or without access ports) or other surgeries in which access is limited, including ear, nose, and throat procedures. Articulation motions may be transferred from a handle to needle grasping jaws using an axial movement of a shaft that has axial stiffness (such as being stiff in compression) and lateral flexibility or an axial movement of a cable. An extension body (within which the shaft or cable moves) between the handle and jaws can be pre-bent or custom bent by the user. Portions of the devices may be disposable, replaceable, and/or reusable. A spring adjacent the clamp may open the clamp or impose a gripping force. | 03-07-2013 |
20140222036 | Suturing Device, System, and Method - Improved medical suturing devices, systems, and methods may hold a suture needle at a fixed location relative to a handle of the device, allowing the surgeon to grasp and manipulate the handle of the suturing device to insert the needle through tissues in a manner analogous to use of a standard needle gripper. Cycling the handle from a closed position to an open position and back to the closed position may alternate the device between gripping the needle with a first clamp (for example, along a proximal portion of the needle) to gripping the needle with a second clamp (for example, along a distal portion of the needle) and optionally back to gripping with the first clamp, with the needle often staying at a substantially fixed location relative to the suturing device body. Related single-clamp needle grasping devices can be bent plastically by a surgeon, and/or have bodies that are grasped by a hand while a portion of the hand actuates a handle. | 08-07-2014 |
20140288581 | REPLACEABLE TIP SUTURING DEVICES, SYSTEM, AND METHODS FOR USE WITH DIFFERING NEEDLES - Medical suturing devices, systems, and methods will be useful for endoscopic or open surgeries, including ear, nose, and throat procedures. Articulation motions may be transferred from a handle to needle grasping jaws using an axial movement of a shaft. Portions of the devices may be disposable, replaceable, and/or reusable, with different needle-grasping jaws and/or different elongate extension bodies having different configurations optionally being selectably coupleably to an articulatable handle and housing so as to allow the user to configure the device for a particular procedure. | 09-25-2014 |