Patent application number | Description | Published |
20080227088 | Approaches to Identify Less Harmful Tobacco and Tobacco Products - Aspects of the invention concern methods for detecting, identifying and evaluating tobacco and tobacco products to determine the potential that these compositions have to contribute to a tobacco-related disease. It is based, at least in part; on the discovery that exposure of pulmonary cells to smoke or smoke condensate obtained from tobacco or tobacco products induces double stranded breaks in cellular DNA, which were efficiently detected using assays that measure the presence, absence, or amount of phosphorylation of the histone, H2AX. | 09-18-2008 |
20100132726 | APPROACHES TO IDENTIFY LESS HARMFUL TOBACCO AND TOBACCO PRODUCTS - Aspects of the invention concern methods for detecting, identifying and evaluating tobacco and tobacco products to determine the potential that these compositions have to contribute to a tobacco-related disease. It is based, at least in part; on the discovery that exposure of pulmonary cells to smoke or smoke condensate obtained from tobacco or tobacco products induces double stranded breaks in cellular DNA, which were efficiently detected using assays that measure the presence, absence, or amount of phosphorylation of the histone, H2AX. | 06-03-2010 |
20100206317 | REDUCED RISK TOBACCO PRODUCTS AND USE THEREOF - Reduced risk tobacco-related products and methods of use. These tobacco-related products (e.g., cigarettes or filters) are designed to reduce the biological insult, for example, DSBs, cell death or perturbation of RNA transcriptome or proteome as compared to the amount of biological insult induced by another cigarette, such as a conventional or reference cigarette (e.g., 2R4F), in human cells, and to provide a reduced risk cigarette that meets a cigarette smoker's sensory/perception needs. | 08-19-2010 |
20100273171 | GLOBAL GENE EXPRESSION ANALYSIS OF HUMAN BRONCHIAL EPITHELIAL CELLS EXPOSED TO CIGARETTE SMOKE, SMOKE CONDENSATES, OR COMPONENTS THEREOF - Aspects of the present invention concern the identification of several methods to analyze the genes that are modulated in normal human bronchial epithelial (NHBE) cells after exposure to cigarette smoke condensates (CSC) or cigarette smoke (CS). Embodiments described herein include methods to identify a gene that is modulated in response to exposure to CSC or CS, methods to identify tobacco products that have a reduced potential to contribute to tobacco-related disease, methods to make tobacco products that have a reduced potential to contribute to a tobacco-related disease, methods to identify a subject's predilection to acquire a tobacco related disease, the use of particular genes as biomarkers for tobacco-related disease, and patterns of gene expression or genetic signatures that are unique to each particular tobacco product. | 10-28-2010 |
20110005534 | REDUCED RISK TOBACCO PRODUCTS AND USE THEREOF - Reduced risk tobacco-related products and methods of use. These tobacco-related products (e.g., cigarettes or filters) are designed to reduce the biological insult, for example, DSBs, cell death or perturbation of RNA transcriptome or proteome as compared to the amount of biological insult induced by another cigarette, such as a conventional or reference cigarette (e.g., 2R4F), in human cells, and to provide a reduced risk cigarette that meets a cigarette smoker's sensory/perception needs. | 01-13-2011 |
20110173721 | REDUCED RISK TOBACCO PRODUCTS AND METHODS OF MAKING SAME - Embodiments provided herein concern tobacco and tobacco products having a reduced amount of a harmful compound. More specifically, several embodiments concern approaches to modify the expression of a gene that is involved in the production of a harmful compound in tobacco, tobacco products made using these approaches and methods of determining whether the removal of said compounds using said approaches yields a tobacco and/or a tobacco product that has a reduced potential to contribute to a tobacco-related disease. | 07-14-2011 |
20110214680 | APPROACHES TO IDENTIFY LESS HARMFUL TOBACCO AND TOBACCO PRODUCTS - Aspects of the invention concern methods for detecting, identifying and evaluating tobacco and tobacco products to determine the potential that these compositions have to contribute to a tobacco-related disease. It is based, at least in part; on the discovery that exposure of pulmonary cells to smoke or smoke condensate obtained from tobacco or tobacco products induces double stranded breaks in cellular DNA, which were efficiently detected using assays that measure the presence, absence, or amount of phosphorylation of the histone, H2AX. | 09-08-2011 |
20140174460 | REDUCED RISK TOBACCO PRODUCTS AND METHODS OF MAKING SAME - Embodiments provided herein concern tobacco and tobacco products having a reduced amount of a harmful compound. More specifically, several embodiments concern approaches to modify the expression of a gene that is involved in the production of a harmful compound in tobacco, tobacco products made using these approaches and methods of determining whether the removal of said compounds using said approaches yields a tobacco and/or a tobacco product that has a reduced potential to contribute to a tobacco-related disease. | 06-26-2014 |
Patent application number | Description | Published |
20120005213 | METHODS AND APPARATUS TO OBTAIN ANONYMOUS AUDIENCE MEASUREMENT DATA FROM NETWORK SERVER DATA FOR PARTICULAR DEMOGRAPHIC AND USAGE PROFILES - Methods and apparatus to obtain anonymous audience measurement data from network server data for particular demographic and usage profiles are disclosed. An example method to provide anonymous audience measurement data to an audience measurement entity disclosed herein comprises obtaining a demographic profile and a network usage profile, sampling customer data stored in a customer database not accessible by the audience measurement entity to generate a customer sample representative of the demographic profile and the network usage profile without customer intervention, the customer sample including customer identification information, processing log data obtained from a network server not accessible by the audience measurement entity using the customer identification information to determine audience measurement data associated with customers in the customer sample, and removing the customer identification information from the audience measurement data to prepare the anonymous audience measurement data for the audience measurement entity. | 01-05-2012 |
20130036435 | METHODS AND APPARATUS TO OBTAIN ANONYMOUS AUDIENCE MEASUREMENT DATA FROM NETWORK SERVER DATA FOR PARTICULAR DEMOGRAPHIC AND USAGE PROFILES - Methods and apparatus to obtain anonymous audience measurement data from network server data for particular demographic and usage profiles are disclosed. An example method to provide anonymous audience measurement data to an audience measurement entity disclosed herein comprises obtaining a demographic profile and a network usage profile, sampling customer data stored in a customer database not accessible by the audience measurement entity to generate a customer sample representative of the demographic profile and the network usage profile without customer intervention, the customer sample including customer identification information, processing log data obtained from a network server not accessible by the audience measurement entity using the customer identification information to determine audience measurement data associated with customers in the customer sample, and removing the customer identification information from the audience measurement data to prepare the anonymous audience measurement data for the audience measurement entity. | 02-07-2013 |
20150081704 | METHODS AND APPARATUS TO OBTAIN ANONYMOUS AUDIENCE MEASUREMENT DATA FROM NETWORK SERVER DATA FOR PARTICULAR DEMOGRAPHIC AND USAGE PROFILES - Example audience measurement methods disclosed herein include accessing demographic information and identification information for subscribers of a service provider based on first data received from an audience measurement entity. Such disclosed example methods also include accessing network log data stored by the service provider for the subscribers using the identification information. Such disclosed example methods further include determining audience measurement data for the subscribers based on the network log data, the demographic information and the identification information, and removing the identification information from the audience measurement data to determine anonymous audience measurement data to send to the audience measurement entity. | 03-19-2015 |
Patent application number | Description | Published |
20140232106 | SUMP WALL PENETRATION FITTING - A penetration fitting includes a first fitting half having an inner surface and an outer surface opposite the inner surface, the first fitting half defining an arcuate channel, and a second fitting half having an inner surface and an outer surface opposite the inner surface, the second fitting half defining an arcuate channel, wherein the first and second fitting halves are adapted to abut one another with the inner surfaces of the first and second fitting halves together defining an inner end, the outer surfaces of the first and second fitting halves defining an outer end, and the arcuate channels of the first and second fitting halves cooperating to define a tapered opening configured to accept the at least one pipe segment, the opening having a larger diameter at the inner end and a smaller diameter at the outer end. | 08-21-2014 |
20140265157 | SUMP WALL PENETRATION FITTING FOR FLEXIBLE PIPING - A penetration fitting configured to form a seal around a flexible pipe penetrating through an aperture in a sump wall is provided. In one embodiment, the penetration fitting includes first and second fitting halves defining first and second arcuate channels having a wider end and a narrower end, wherein the first and second fitting halves are configured to abut one another with the arcuate channels of the first and second fitting halves together defining a tapered opening, the tapered opening having a smaller diameter at an inner end and a larger diameter at an outer end with the inner end configured to be sealed to the sump wall around the aperture, an elastically deformable sealing ring configured to be received in the tapered opening, the sealing ring defining an opening configured to accept the flexible pipe, and a compression plate configured to retain the sealing ring in the tapered opening. | 09-18-2014 |