Akoulitchev
Alexandre Akoulitchev, Oxfordshire GB
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20110098342 | METHODS OF DETECTING LONG RANGE CHROMOSOMAL INTERACTIONS - The present invention relates to a method of monitoring epigenetic changes comprising monitoring changes in conditional long range chromosomal interactions at at least one chromosomal locus where the spectrum of long range interaction is associated with a specific physiological condition, the method comprising the steps of: —(i) in vitro crosslinking of said long range chromosomal interactions present at the at least one chromosomal locus; (ii) isolating the cross linked DNA from said chromosomal locus; (iii) subjecting said cross linked DNA to restriction digestion with an enzyme that cuts at least once within the at least one chromosomal locus; (iv) ligating said cross linked cleaved DNA ends to form DNA loops; (v) identifying the presence of said DNA loops; wherein the presence of DNA loops indicates the presence of a specific long range chromosomal interaction. | 04-28-2011 |
Alexandre Akoulitchev, Oxford GB
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20090186352 | DNA Conformation - Method of detection or diagnosis of abnormal gene expression in an individual comprising determining in a sample from the individual the presence or absence of a chromosome structure in which two separate regions of the gene have been brought into close proximity, to thereby detect or diagnose whether the individual has abnormal gene expression. | 07-23-2009 |
20150317795 | METHOD FOR ASSESSING CELL AGING - The present invention relates to a method for determining a change in the mobility of a population of organisms over time, said method comprising: a) obtaining a first image ( | 11-05-2015 |
Alexandre Akoulitchev, Ewelme GB
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20120136046 | METHOD OF TREATING AGE RELATED DISORDERS - The present invention relates to the use of fujimycin for the treatment of a disorder related to the chronological and/or replicative life-span of a cell, and to methods for increasing the replicative life span of a cell, said method comprising disrupting the function of a polynucleotide or gene encoding a polypeptide comprising SEQ ID No: 1, 3 or 5. | 05-31-2012 |
20120270213 | SCREENING METHOD FOR CELL AGING - The present invention relates to a method for increasing the chronological lifespan of a cell comprising disrupting the function of at least one of the SAGA1 SLIK and/or SALSA complexes in said cell. | 10-25-2012 |
Alexandre Akoulitchev, Yarnton GB
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20140162271 | METHODS OF DETECTING LONG RANGE CHROMOSOMAL INTERACTIONS - The present invention relates to a method of monitoring epigenetic changes comprising monitoring changes in conditional long range chromosomal interactions at at least one chromosomal locus where the spectrum of long range interaction is associated with a specific physiological condition, the method comprising the steps of:— | 06-12-2014 |
Alexandre Akoulitchev, Ewelme, Oxfordshire GB
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20160120853 | TACROLIMUS AND ANALOGUES THEREOF FOR MEDICAL USE - The present invention relates to a method of treating adverse fat accumulation and related conditions with very low doses of tacrolimus or a close structural analogue thereof. In particular this invention relates to treating adverse fat accumulation and/or sarcopenia and/or metabolic syndrome inpatients by administering tacrolimus in very low dose. Most particularly this invention relates to the use of tacrolimus in treating age related fat accumulation. | 05-05-2016 |