Aimetti
Alex Aimetti, Superior, CO US
Patent application number | Description | Published |
---|---|---|
20130197189 | Method For Synthesizing A Cyclic Multivalent Peptide Using A Thiol-Mediated Reaction - A method has been developed for the formation of multivalent cyclic peptides. This procedure exploits on-resin peptide cyclization using a photoinitiated thiol-ene click reaction and subsequent clustering using thiol-yne photochemistry. Both reactions utilize the sulfhydrl group on natural cysteine amino acids to participate in the thiol-mediated reactions. | 08-01-2013 |
Alex Aimetti, Waltham, MA US
Patent application number | Description | Published |
---|---|---|
20130142781 | PEG BASED HYDROGEL FOR PERIPHERAL NERVE INJURY APPLICATIONS AND COMPOSITIONS AND METHOD OF USE OF SYNTHETIC HYDROGEL SEALANTS - Hydrogels that may be used for treating peripheral nerves and related methods are provided. Synthetic hydrogel sealants, methods of forming synthetic hydrogel sealants, and the use of synthetic hydrogel sealants are provided. | 06-06-2013 |
20130149318 | PAINTING THE PIA, ARACHNOID, AND SPINAL CORD PARENCHYMA - A PEG based hydrogel and a procedure for its topical application to the surface of the pia mater of the spinal cord that can be used for intrathecal delivery of diverse drug and biomolecular therapies for the treatment of traumatic central nervous system injuries and disorders including spinal cord injury (SCI), multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) are provided. This “painting of the pia” with biofunctionalized hydrogel material may be used as a prelude strategy in the therapeutic management of these CNS disorders. The strategy may be designed to create a microenvironment within the damaged regions of the spinal cord that is more conducive to the successful application of subsequent regeneration based treatments such as cell replacement therapies or endogenous regeneration and plasticity stimulation via application of growth factors or gene therapy. Compositions and methods for topical application of the PEG based hydrogel to the arachnoid mater, the intrathecal portions of the spinal nerves, and application directly to the spinal cord parenchyma are also provided. | 06-13-2013 |
Alex A. Aimetti, Waltham, MA US
Patent application number | Description | Published |
---|---|---|
20140271601 | CROSSLINKABLE TREHALOSE FOR THE COVALENT INCORPORATION IN HYDROGELS AND METHODS OF USE - Methods of controlled delivery of bioactive therapeutics are provided. Compositions comprising therapeutic implants are provided. | 09-18-2014 |
Alex Arthur Aimetti, Waltham, MA US
Patent application number | Description | Published |
---|---|---|
20150025005 | SELF-REGULATED PEPTIDE HYDROGEL FOR INSULIN DELIVERY - A glucose binding amphiphilic peptide hydrogel insulin delivery system that is responsive to glucose concentrations under physiological conditions is provided. Insulin is encapsulated in a glucose binding hydrogel, made from self-assembling amphiphilic peptides including a hydrophobic domain including a beta sheet forming region coupled to a charged hydrophilic domain modified to contain a glucose binding segment. The formulations are designed to release insulin as a function of blood glucose level, maintaining the patients' blood glucose level in an optimum range and avoiding both hyper- and hypoglycemia. | 01-22-2015 |