Patent application number | Description | Published |
20080241351 | USING MAGNETISM TO PREPARE A MEDICAL DEVICE - The present invention is directed to methods, processes, and systems for delivering therapeutic agent to a medical device. Under some methods, processes, and systems of the invention, particles including a magnetic material and a therapeutic agent may be directed towards a medical device via magnetic attraction. In another embodiment particles including a magnetic material may force a therapeutic agent/solvent solution into porous matrix by using a magnetic attraction. In still another embodiment, a medical device having at least a portion thereof including a magnetic material is used to attract and adhere particles comprising magnetic material and therapeutic agent to a target surface of the medical device, wherein the particles are fused to the target surface. | 10-02-2008 |
20090068339 | ENDOPROSTHESES HAVING POROUS CLADDINGS PREPARED USING METAL HYDRIDES - A process for making an endoprosthesis comprising: (a) applying a powder that includes a metal hydride to a surface of a metal endoprosthesis, or precursor tubing thereof; and (b) exposing the powder to a heat source to melt the powder and liberate hydrogen gas, thereby forming a porous coating on the surface of the endoprosthesis, or precursor tubing thereof. | 03-12-2009 |
20090081272 | MEDICAL DEVICES HAVING A METAL PARTICULATE COMPOSITION FOR CONTROLLED DIFFUSION - An implantable or insertable medical device is provided which includes as components: (a) a substrate component comprising a depression that is at least partially filled with a therapeutic agent-containing material that comprises a first therapeutic agent, and (b) a particulate composition disposed in the depression such that it regulates transport of chemical species between the depression and the exterior of the device upon implantation or insertion of the device into a subject. | 03-26-2009 |
20090082856 | MEDICAL DEVICES HAVING NANOFIBER-TEXTURED SURFACES - According to an aspect of the present invention, medical devices are provided which comprise (a) a substrate having first and second surfaces, (b) a nanofiber-textured layer comprising nanofibers disposed over at least the first surface of the substrate and defining a nanotextured outer surface for the device, and (c) a therapeutic-agent-eluting layer comprising a therapeutic agent and a polymer disposed over at least the second surface of the substrate. | 03-26-2009 |
20090104244 | THERAPEUTIC AGENT-ELUTING MEDICAL DEVICES HAVING TEXTURED POLYMERIC SURFACES - A medical device comprising: (a) a substrate having first and second surfaces, (b) a therapeutic-agent-eluting polymeric layer disposed over the first substrate surface and (c) a textured polymeric layer that is textured to promote cell attachment, cell growth, or both, disposed over the second surface. | 04-23-2009 |
20090123517 | MEDICAL DEVICES FOR RELEASING THERAPEUTIC AGENT AND METHODS OF MAKING THE SAME - An implantable medical device for releasing therapeutic agent having a medical device body and a plurality of reservoir-defining structures disposed on a surface of the body. A reservoir can be defined by the reservoir-defining structures and therapeutic agent may be located in the reservoir. A cover may extend over the reservoir so that the therapeutic agent is released from the reservoir when the medical device implanted. Methods for making the medical device may also include providing a medical device body, positioning a plurality of reservoir-defining structures on a surface of the body to form a reservoir, loading therapeutic agent into the reservoir, and covering the reservoir so that the therapeutic agent may release when the medical device is implanted. Alternatively, the reservoir may be covered with a cover and an opening formed in the cover so that the therapeutic agent may release when the medical device is implanted. | 05-14-2009 |
20090123521 | Medical devices having coatings for controlled therapeutic agent delivery - According to an aspect of the invention, medical devices are provided, which include a nanoparticle-derived inorganic layer disposed over a least a portion of structure that includes a substrate, and optionally, a therapeutic-agent-containing layer disposed over at least a portion of the substrate. In some embodiments, the inorganic layer is a nanoporous inorganic layer. Other aspects of the invention comprise methods for forming such medical device. | 05-14-2009 |
20090264975 | MEDICAL DEVICES HAVING A COATING OF INORGANIC MATERIAL - In one aspect, a medical device has a first configuration and a second configuration, a reservoir containing a therapeutic agent, and a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material. In another aspect, a medical device has a reservoir containing a therapeutic agent, a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material, and a swellable material disposed between the barrier layer and a surface of the medical device, wherein the swellable material is a material that swells upon exposure to an aqueous environment. In yet another aspect, a medical device has a multi-layered coating having alternating reservoir layers and barrier layers, and a plurality of excavated regions penetrating through at least a partial thickness of the multi-layered coating. In yet another aspect, a medical device has a polymer layer comprising a block co-polymer, wherein the polymer layer contains a therapeutic agent, and a barrier layer disposed over the polymer layer, wherein the barrier layer comprises an inorganic material, and wherein the barrier layer has a plurality of discontinuities. Methods of forming coatings on medical devices and methods of delivering therapeutic agents to body sites are also disclosed. | 10-22-2009 |
20090299283 | Balloon Design and Weld Design to Increase EAS of Re-Wrapping and Decrease Withdrawal Force - A balloon catheter that has at least one shaft, and a balloon. The balloon has a first weld region, a first cone region, a middle region, a second cone region and a second weld region where the first weld region engages the balloon to the at least one shaft, the first region is adjacent to the first weld region, the middle region is between the first cone region and the second cone region, the second cone region is adjacent to the second weld region, and the second weld region engages the balloon to at least one shaft. The balloon has an uninflated state and an inflated state, where the balloon has at least one fold extending from the first weld region to the second weld region in the uninflated state and the first and second cone regions of the balloon have at least one fold in the inflated state. | 12-03-2009 |
20100055151 | MEDICAL DEVICES HAVING COATINGS FOR THERAPEUTIC AGENT DELIVERY - According to an aspect of the invention, implantable and insertable medical devices are provided that include (a) a substrate, (b) a porous layer comprising interconnected pores disposed over the substrate, (c) at least one first therapeutic agent disposed within and/or beneath the porous layer, (d) a composite layer disposed over the porous layer that includes (i) at least one therapeutic agent eluting region containing at least one second therapeutic agent and at least one matrix material and (ii) at least one bioerodible region containing at least one bioerodible material that extends from the surface of the composite layer to the porous layer. | 03-04-2010 |
20100269838 | MAGNETIC PARTICLES FOR DELIVERING THERAPEUTIC AGENT TO A TARGET LOCATION - A system for delivering therapeutic agent to a target location in a body in accordance with one embodiment is provided comprising a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, and a magnetic device for attracting the magnetic particles to a target location. The magnetic particles may be delivered by a catheter into a blood vessel upstream from the target location so that they travel toward the target location. A method for delivering therapeutic agent to a target location in a body in accordance with another embodiment comprises providing a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, placing a magnetic device in a position to attract the magnetic particles to a target location, and allowing the magnetic particles to infuse the target location by the attraction of the magnetic particles to the magnetic device. The therapeutic agent may comprises a therapeutic agent for preventing or treating reperfusion injury, and the step of providing the plurality of magnetic particles may comprise delivering the plurality of magnetic particles through a blood vessel. | 10-28-2010 |
20100331760 | BIODEGRADABLE IMPLANT FOR TREATING OR PREVENTING REPERFUSION INJURY - A biodegradable implant for iontophoretic therapeutic agent delivery is provided. The implant comprises a biodegradable battery and at least one biodegradable iontophoresis electrode assembly. The biodegradable battery comprises first and second biodegradable electrodes and a biodegradable polymer electrolyte layer between the first and second biodegradable electrodes. The biodegradable iontophoresis electrode assembly comprises a biodegradable iontophoresis electrode and a charged therapeutic agent. When the biodegradable battery is electrically connected to generate an electric current through the biodegradable iontophoresis electrode assembly, the charged therapeutic agent is delivered by iontophoresis to a target location. The charged therapeutic agent may be a scavenger for reactive oxygen species. The electrical connection of the biodegradable battery may be controlled remotely. | 12-30-2010 |
20100331775 | IMPLANTABLE SELF-POWERED BIODEGRADABLE MEDICAL DEVICE TO TREAT OR PREVENT REPERFUSION INJURY - In one embodiment, the present disclosure provides a biodegradable, self-powered medical device for preventing or reducing reperfusion injury, comprising a galvanic cell, the galvanic cell comprising: a first biodegradable electrode member; and a second biodegradable electrode member comprising a biodegradable conductive polymer and an electrode-releasable therapeutic agent, wherein the galvanic cell generates an electric force sufficient to cause the electrode-releasable therapeutic agent to be released from the biodegradable conductive polymer and elute to a target location. The device may further include a reservoir material containing a burst-release therapeutic agent. | 12-30-2010 |
20110008260 | Use of Nanocrystals for Drug Delivery from a Balloon - A drug delivery balloon ( | 01-13-2011 |
20110045055 | MEDICAL DEVICES CONTAINING THERAPEUTIC AGENTS - According to one aspect of the invention, implantable or insertable medical devices are provided which can delay release of one or more therapeutic agents for a predetermined time after implantation in a subject. In various embodiments, a therapeutic agent delivery profile of this type is provided by employing a temporary barrier layer which initially permits little to no release of the therapeutic agent, but which layer permits much greater release levels after a predetermined period of time. Other aspects of the invention relate to methods of forming such devices and to methods of using such devices. | 02-24-2011 |
20110130829 | Medical Devices Containing Therapeutic Agents - The present invention pertains to implantable or insertable medical devices which comprise a substrate and one or more therapeutic-agent-containing regions contain one or more therapeutic agents. In various aspects of the invention, one or more characteristics of such therapeutic-agent-containing regions are controlled. Further aspects of the invention relate to methods of forming such devices and to methods of using such devices. | 06-02-2011 |
20120259405 | Radial Radiopaque Markers - A deployable medical device having at least one radiopaque marker is herein disclosed. In particular, the deployable medical device comprises a bio-absorbable stent or expandable medical balloon. Upon insertion of the deployable medical device, the at least one radiopaque marker is inserted into adjacent tissue, where it will remain even after the deployable medical device has been removed. | 10-11-2012 |
20130338698 | TRANSCATHETER AORTIC VALVULOPLASTY DEVICE - A valvuloplasty device comprises an expandable anchor and an expansion member mounted about an outer surface of the expandable anchor. The expansion member is either an annular balloon or a sleeve. The valvuloplasty device can be used for valvuloplasty and for valve implantation. | 12-19-2013 |