Aguirre, US
Alvaro Cesar Aguirre, Port Charlotte, FL US
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20140167373 | Rolling PVC cart for curbside ricycle bins - The main purpose of my Rolling Recycle Bin Dolly, or Cart, is to make easier the task of taking the household recycling items like paper, cardboard, glass, plastic containers, etc, out to the curb to be picked up. It allows the user to transport both bins in one single trip, with minimum effort as opposed to carrying them by hand. This also helps to avoid physical injuries caused by lifting heavy loads. | 06-19-2014 |
Ana Aguirre, Chicago, IL US
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20160068521 | THIAZOLES AND USES THEREOF - This disclosure relates to: (a) compounds and salts thereof that, inter alia, inhibit RSV infection and/or replication; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions. | 03-10-2016 |
Ana L. Aguirre, Chicago, IL US
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20150210720 | FURO-3-CARBOXAMIDE DERIVATIVES AND METHODS OF USE - Compounds of formula (I) | 07-30-2015 |
Andres Aguirre, Coral Gables, FL US
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20090103700 | SYSTEM AND METHOD FOR MODELING, MONITORING AND MANAGING TELECOMMUNICATIONS NETWORKS AND INFRASTRUCTURE - An analyzing a telecommunications network that receives environmental data, vendor data, and customer data related to a telecommunications transaction. A telecommunications transaction identifier is generated for each telecommunications transaction to determine attributes associated with each telecommunications transaction. The telecommunications transaction identifier and the attributes associated with the identified telecommunications transaction are mapped to a customer-specific parameter. The telecommunications network determines whether the transaction conforms to the parameters. | 04-23-2009 |
Andres Aguirre, Belmont, MA US
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20130158627 | APPARATUS AND METHOD FOR RELIEVING PAIN USING TRANSCUTANEOUS ELECTRICAL NERVE STIMULATION - Apparatus for transcutaneous electrical nerve stimulation in humans, comprising a housing; stimulation means mounted within the housing for electrically stimulating nerves; an electrode array releasably mounted to the housing, connectable to the stimulation means, and comprising electrodes for electrical stimulation of nerves; control means mounted to the housing and electrically connected to the stimulation means for controlling the stimulation means; monitoring means mounted to the housing and electrically connected to the stimulation means for monitoring the stimulation means; user interface means mounted to the housing and electrically connected to the control means for controlling the stimulation means; display means mounted to the housing and electrically connected to the control means and the monitoring means for displaying the status of the stimulations means; and a strap attached to the housing and configured to hold the housing, stimulation means and electrode array at a specific anatomical location to treat pain. | 06-20-2013 |
20140296934 | DETECTING CUTANEOUS ELECTRODE PEELING USING ELECTRODE-SKIN IMPEDANCE - Apparatus for transcutaneous electrical nerve stimulation in a user, the apparatus comprising: | 10-02-2014 |
20140296935 | TRANSCUTANEOUS ELECTRICAL NERVE STIMULATOR WITH USER GESTURE DETECTOR AND ELECTRODE-SKIN CONTACT DETECTOR, WITH TRANSIENT MOTION DETECTOR FOR INCREASING THE ACCURACY OF THE SAME - Apparatus for transcutaneous electrical nerve stimulation in a user, the apparatus comprising: | 10-02-2014 |
20150148865 | APPARATUS AND METHOD FOR RELIEVING PAIN USING TRANSCUTANEOUS ELECTRICAL NERVE STIMULATION - Apparatus for transcutaneous electrical nerve stimulation in humans, the apparatus comprising: | 05-28-2015 |
AndrÉs Aguirre, Chicago, IL US
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20130226205 | Pediatric Esophageal Atresia Magnetic Anastomosis System - A system and a method for joining an upper and lower esophageal sacs in an infant are provided. The system includes a first elongate member having a first magnet, the first magnet including an end portion configured to abut an interior surface of the upper esophageal sac. The system also includes a second elongate member having a second magnet, the second magnet including an end portion configured to abut an interior surface of the lower esophageal sac. The system further includes a third elongate member having a third magnet and a spacer positioned distal to the third magnet. The third elongate member is positionable in the upper esophageal sac after the first elongate member has been removed. A magnetic force between the first magnet and the second magnet is configured to pull the first magnet and the second magnet towards each other to lengthen the upper and lower esophageal sacs. | 08-29-2013 |
Andres F. Aguirre, Chicago, IL US
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20110118546 | BALLOON CATHETER WITH DETACHABLE HUB, AND METHODS FOR SAME - A balloon catheter may include a distal anchoring balloon and a proximal hub that is removable from the catheter body. The catheter body may include a valve structure providing for maintaining the balloon in an inflated state during and after removal of the proximal hub. The valve preferably is constructed such that removal of the hub provides a low-profile proximal catheter end that will allow that proximal catheter end to pass through an endoscopic surgical device such as, for example, through an accessory channel of a standard duodenoscope and/or an ultra-slim endoscope/cholangioscope, facilitating a scope-exchange for use during, for example, a cholangioscopy or pancreatoscopy procedure. A method useful for scope exchange and/or introducing another elongate surgical device may utilize a balloon catheter with a distal anchoring balloon and a proximal hub that is removable from the catheter body. | 05-19-2011 |
20110118765 | ANASTOMOSIS STENT - A stent made of single nitinol wire or other biocompatible material having shape memory properties may be configured to define a flower-like configuration generally providing a proximal plane and a distal plane, each generally centered around a generally cylindrical passage and configured for maintaining patency of an anastomosis or other opening. The wire or other biocompatible material may include a shroud or other covering and may also include one or more loops configured to allow relatively secure engagement of sutures. Methods of deployment are also provided. | 05-19-2011 |
20110160752 | ELONGATE MAGNET FOR A MAGNETIC ANASTOMOSIS DEVICE - A magnetic anastomosis device is provided for forming an anastomosis between two bodily walls. The device includes a first magnet assembly and a second magnet assembly configured to be magnetically coupled to compress the two bodily walls therebetween to form the anastomosis. The first magnet assembly includes a first magnet and a second magnet disposed within a first jacket and the second magnet assembly includes a third magnet and a fourth magnet disposed within a second jacket. | 06-30-2011 |
20110288534 | DEVICE FOR EXTERNAL PERCUTANEOUS CONNECTIONS - The present invention provides devices for creating an external percutaneous fluidic connections. In one embodiment, the device includes a first tube defining a longitudinal axis, and a first bolster supporting the first tube, a second tube, and a second bolster supporting the second tube. The first and second bolsters are magnetically attractable, and promote airflow to the skin. | 11-24-2011 |
20120010470 | DEVICES AND METHODS FOR ANCHORING A TUBE - Devices and methods are provided for accessing a bodily opening that, among other things, are safe, reliable and repeatable. One embodiment of a device for anchoring to tissue includes an elongated tube and a magnet. The elongated tube has a proximal end opposite a distal end, and defines a central axis. The magnet is attached to the distal end of the elongated tube and has a magnetic field attractive to the magnetic material in the tissue. The magnet has an annular shape defining an aperture through which the elongated tube extends. | 01-12-2012 |
20120016391 | MEDICAL DEVICES WITH DETACHABLE PIVOTABLE JAWS - Medical systems, devices and methods are provided for engaging tissue, e.g. for clipping tissue, closing a perforation or performing hemostasis. Generally, the medical system including a housing, first and second jaws rotatable relative to the housing, a driver, and an elongate drive wire. The elongate drive wire may be disconnected from the driver, first and second jaws, and the housing, which are left in vivo engaged with the tissue. | 01-19-2012 |
20120035628 | DELIVERY SYSTEM FOR MAGNETIC ANASTOMOSIS DEVICE - A magnet delivery system for forming an anastomosis that comprises a wire guide; a catheter having a delivery portion for advancement into a intracorporeal space, the delivery portion having a lumen extending at least partially therethrough, and a strand connected to the catheter, whereby the magnet is disposed over the wire guide and distal to the catheter, and retained by the strand being releasably connected to the wire guide. | 02-09-2012 |
Andres F. Aguirre, Burlington, NC US
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20100160931 | VARIABLE THICKNESS TACKING DEVICES AND METHODS OF DELIVERY AND DEPLOYMENT - The present embodiments provide a tacking device for engaging tissue, which may be useful for coupling a graft member to tissue or facilitating closure of a bodily opening. In one embodiment, the tacking device comprises a main body having proximal and distal ends, a proximal base member disposed at the proximal end of the main body, and at least one tissue engaging member disposed at the distal end of the main body. A spring member is disposed to surround the main body and extends from the proximal base member. In use, the spring member has a relaxed state in which it is biased to extend distally towards the at least one tissue engaging member, and further has a compressed state in which the distal end of the spring member is spaced further apart from the at least one tissue engaging member. Therefore, one or more tissue segments of varying thickness are adapted to be captured between the distal end of the spring member and the at least one tissue engaging member. A delivery system and methods for deploying the tacking device also are provided. | 06-24-2010 |
20100160935 | CLIP DEVICES AND METHODS OF DELIVERY AND DEPLOYMENT - The present embodiments provide a clip device for engaging tissue. The clip device comprises at least first and second arms having proximal and distal ends. The clip device comprises an open state when the spring member is in a compressed state in which the distal end of the spring member is spaced further apart from the distal ends of the first and second arms. In the open state, the distal ends of the first and second arms tend to be spaced apart from each other. Further, the clip device comprises a closed state when the spring member is in a relaxed state in which the spring member is biased to extend distally towards the distal ends of the first and second arms. In the closed state, the distal ends of the first and second arms are adjacent to each other and may engage tissue and promote hemostatis. A delivery system and methods for deploying one or more clip devices also are provided. | 06-24-2010 |
20100292541 | SYSTEMS, DEVICES AND METHODS FOR ACCESSING A BODILY OPENING - Medical systems, devices and methods are provided for accessing a bodily opening that, among other things, are safe and reliable, and facilitate manipulation of a medical instrument. The medical access device generally includes an elongated flexible sheath and an expandable frame connected to the distal end of the flexible sheath. The sheath and expandable frame are operable between expanded and collapsed configurations to provide a pathway from a natural orifice to the bodily opening. | 11-18-2010 |
20100292729 | Delivery System for Magnetic Anastomosis Device - A magnet delivery system for forming an anastomosis that comprises a wire guide; a catheter having a delivery portion for advancement into a visceral space, the delivery portion having a lumen extending at least partially therethrough and an expandable balloon for dilation and a lumen extending therethrough, a first port and a second port in communication with the lumen through which the wire guide is disposed; a magnet comprising a lumen therethrough wherein the magnet is removably secured to the delivery portion of the catheter between the first and second ports by disposing the wire guide through the lumen of the magnet, the first port and the second port. | 11-18-2010 |
Andrew J. Aguirre, Brookline, MA US
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20080242742 | Animal models of pancreatic adenocarcinoma and uses therefor - The present invention is based, at least in part, on the generation of an animal model of pancreatic adenocarcinoma which recapitulates the genetic and histological features of human pancreatic adenocarcinoma, including the initiation, maintenance, and progression of the disease. Accordingly, the present invention provides animal models of cancer, e.g., pancreatic adenocarcinoma, wherein an activating mutation of Kras has been introduced, and any one or more known or unknown tumor suppressor genes or loci, e.g., Ink4a/Arf, Ink4a, Arf, p53, Smad4/Dpc, Lkb1, Brca2, or Mlh1, have been misexpressed, e.g., have been misexpressed leading to decreased expression or non-expression. The animal models of the invention may be used, for example, to identify biomarkers of pancreatic cancer, to identify agents for the treatment or prevention of pancreatic cancer, and to evaluate the effectiveness of potential therapeutic agents. | 10-02-2008 |
Andrew J. Aguirre, Boston, MA US
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20090297536 | Compositions, kits, and methods for identification, assessment, prevention and therapy of cancer - The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human cancer. A variety of chromosomal regions (MCRs) and markers corresponding thereto, are provided, wherein alterations in the copy number of one or more of the MCRs and/or alterations in the amount, structure, and/or activity of one or more of the markers is correlated with the presence of cancer. | 12-03-2009 |
Cristobal Aguirre, Miami, FL US
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20100047749 | HAZARDOUS MATERIAL RESPONSE SYSTEM, METHOD OF USING SAME AND METHOD OF TRAINING FOR SAME - This application describes methods for responding to a hazardous material based upon properties of the hazardous material based on its name. This application also describes methods of teaching hazardous material responders how to use the method of responding to a hazardous material based upon properties of the hazardous material based on its name. | 02-25-2010 |
20130196304 | HAZARDOUS MATERIAL RESPONSE SYSTEM, METHOD OF USING SAME AND METHOD OF TRAINING FOR SAME - This application describes methods for responding to a hazardous material based upon its properties and/or its chemical name. This application also describes methods of teaching hazardous material responders how to use the method of responding to a hazardous material based upon its properties and/or its chemical name. | 08-01-2013 |
20130209975 | HAZARDOUS MATERIAL RESPONSE SYSTEM, METHOD OF USING SAME AND METHOD OF TRAINING FOR SAME - This application describes methods for responding to a hazardous material based upon its properties and/or its chemical name. This application also describes methods of teaching hazardous material responders how to use the method of responding to a hazardous material based upon its properties and/or its chemical name. | 08-15-2013 |
David Aguirre, Springfield, MO US
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20100084421 | VENDING MACHINE USER INTERFACE GUIDE; ELECTRONIC COIN RETURN; AND HINGED DELIVERY BIN - A system and method for directing a consumer through a vending machine transaction. The system and method include a UI guide comprising visual cues to direct a consumer to insert a minimum amount of money, make a production selection and confirm the product selection. The system and method provide for the consumer to cancel the transaction and request that return of inserted coins. | 04-08-2010 |
20120273517 | VENDING MACHINE USER INTERFACE GUIDE; ELECTRONIC COIN RETURN; AND HINGED DELIVERY BIN - A system and method for directing a consumer through a vending machine transaction. The system and method include a UI guide comprising visual cues to direct a consumer to insert a minimum amount of money, make a production selection and confirm the product selection. The system and method provide for the consumer to cancel the transaction and request that return of inserted coins. | 11-01-2012 |
Fernando Aguirre, North Ogden, UT US
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20100111823 | METHODS AND SYSTEMS FOR PRODUCING HYDROGEN AND SYSTEM FOR PRODUCING POWER - Provided herein are methods and systems of producing hydrogen using ammonia borane, which has a high hydrogen density while being stable and easily stored. Ammonia borane may be exothermically reacted with a strong oxidizer, such as a mixture of hydrogen peroxide and water. The reaction between ammonia borane and the strong oxidizer may occur spontaneously and may produce heat. Unreacted ammonia borane may be exposed to and thermally decomposed using the heat produced during the exothermic reaction between ammonia borane and the strong oxidizer. The heat may be retained by performing the reactions in a vessel or reactor including a material capable of retaining the heat. A high gravimetric hydrogen yield is obtained from the reaction of ammonia borane with hydrogen peroxide and the thermal decomposition of unreacted ammonia borane. Hydrogen production using the methods and systems may yield a high gravimetric hydrogen content of at least about 10%. | 05-06-2010 |
Francis M. Aguirre, St. Francis, MN US
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20090029054 | SYSTEM AND METHOD FOR MAKING A FILM HAVING A MATTE FINISH - A system and a method for providing a film having a matte finish. The system includes means for providing a coated substrate, the coated substrate comprising a first coatable material applied to a substrate, the coatable material forming a first major surface of the coated substrate; means for changing the viscosity of the first coatable material from a first viscosity to a second viscosity; a face-side roller having an outer surface positioned to contact the first major surface of the coated substrate to impart a matte finish thereon; and optionally, means for hardening the first coatable material. The method of the invention includes the steps of (1) providing a coated substrate comprising a coatable material disposed on a substrate, the coatable material providing a first major surface of the coated substrate; (2) changing the viscosity of the coatable material from the initial viscosity to a second viscosity; (3) contacting the first major surface of the coated substrate with at least one face-side roller to impart a matte finish; and (4) optionally, hardening the coatable material to provide the film. | 01-29-2009 |
20140057058 | SYSTEM AND METHOD FOR MAKING A FILM HAVING A MATTE FINISH - A system and a method for providing a film having a matte finish. The system includes means for providing a coated substrate, the coated substrate comprising a first coatable material applied to a substrate, the coatable material forming a first major surface of the coated substrate; means for changing the viscosity of the first coatable material from a first viscosity to a second viscosity; a face-side roller having an outer surface positioned to contact the first major surface of the coated substrate to impart a matte finish thereon; and optionally, means for hardening the first coatable material. The method of the invention includes the steps of (1) providing a coated substrate comprising a coatable material disposed on a substrate, the coatable material providing a first major surface of the coated substrate; (2) changing the viscosity of the coatable material from the initial viscosity to a second viscosity; (3) contacting the first major surface of the coated substrate with at least one face-side roller to impart a matte finish; and (4) optionally, hardening the coatable material to provide the film. | 02-27-2014 |
Geoffrey Karl Aguirre, Philadelphia, PA US
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20160073922 | ROBUST TARGETING OF PHOTOSENSITIVE MOLECULES - The present disclosure relates to systems and methods that can be used to stimulate and record responses elicited from a naturally-occurring or artificially-introduced light-sensitive molecule. In certain non-limiting embodiments, a system of the presently disclosed subject matter includes (a) a digital spectral integrator, e.g., light source, (b) a detection means and (c) an integration means. | 03-17-2016 |
Gerardo Aguirre, Boca Raton, FL US
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20140266629 | METHODS, SYSTEMS AND DEVICES FOR ELECTRONIC ARTICLE SURVEILLANCE DEACTIVATION HAVING RANDOMIZED TRANSMISSION RATES - Methods, systems and devices for providing an interrogation signal from a handheld deactivation device for identifying a security tag. Identifying the security tag includes initiating an interrogation signal, wherein the interrogation signal includes plurality of transmission bursts and a plurality of random time periods to wait between transmission bursts such that a unique time period elapses between each of the plurality of transmission bursts. The interrogation signal is then transmitted by transmitting each of the plurality of transmission bursts for a portion of a duty cycle and interrupting transmission between each of the plurality of transmission bursts for one of the plurality of random time periods such that a unique and random time period elapses between each of the plurality of transmission bursts. The period transmission of the interrogation signal provides for improved battery life of a handheld scanning and deactivation device. | 09-18-2014 |
Gerardo Aguirre, Pompano Beach, FL US
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20090051534 | Eas System Providing Synchronized Transmission - A system and method for providing synchronized transmission in an electronic article surveillance (EAS) system is provided. The method includes determining a transmission timing difference between a plurality of units of the EAS system using a communication link of the EAS system and synchronizing transmissions for each of the plurality of units based on the transmission timing difference. | 02-26-2009 |
20100148967 | INTEGRATED DATA READER AND ELECTRONIC ARTICLE SURVEILLANCE (EAS) SYSTEM - An integrated data reader and electronic article surveillance (EAS) system, and methods of operation. Several configurations are also disclosed for alternate deactivation coil designs and mounting schemes. | 06-17-2010 |
20120038480 | INTEGRATED DATA READER AND ELECTRONIC ARTICLE SURVEILLANCE (EAS) SYSTEM - An integrated data reader and electronic article surveillance (EAS) system, and methods of operation. Several configurations are also disclosed for alternate deactivation coil designs and mounting schemes. | 02-16-2012 |
Gustavo Aguirre, Philadelphia, PA US
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20090111976 | Identification of the gene and mutation responsible for progressive rod-cone degeneration in dog and a method for testing same - Tools and methods are provided for determining whether or not a dog is genetically normal, is a carrier of, or is affected with or predisposed to progressive rod-cone degeneration. The method is based on the detection of a transversion from G to A at position corresponding to nucleotide position 1298 of SEQ ID NO: 1. | 04-30-2009 |
20100323349 | Identification of the Gene and Mutation Responsible for Progressive Rod-Cone Degeneration in Dog and a Method for Testing Same - Tools and methods are provided for determining whether or not a dog is genetically normal, is a carrier of, or is affected with or predisposed to progressive rod-cone degeneration. The method is based on the detection of a transversion from G to A at position corresponding to nucleotide position 1298 of SEQ ID NO: 1. | 12-23-2010 |
Gustavo D. Aguirre, Ithaca, NY US
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20090074723 | Method of Treating or Retarding the Development of Blindness - A method for treating an ocular disorder characterized by the defect or absence of a normal gene in the ocular cells of a human or animal subject involves administering to the subject by subretinal injection an effective amount of a recombinant adeno-associated virus carrying a nucleic acid sequence encoding the normal gene under the control of a promoter sequence which expresses the product of the gene in the ocular cells. The ocular cells are preferably retinal pigment epithelial (RPE) cells, and the gene is preferably an RPE-specific gene, e.g., RPE65. The promoter is one that can express the gene product in the RPE cells. Compositions for subretinal administration are useful in this method. | 03-19-2009 |
20100272688 | METHOD OF TREATING OR RETARDING THE DEVELOPMENT OF BLINDNESS - A method for treating an ocular disorder characterized by the defect or absence of a normal gene in the ocular cells of a human or animal subject involves administering to the subject by subretinal injection an effective amount of a recombinant adeno-associated virus carrying a nucleic acid sequence encoding the normal gene under the control of a promoter sequence which expresses the product of the gene in the ocular cells. The ocular cells are preferably retinal pigment epithelial (RPE) cells, and the gene is preferably an RPE-specific gene, e.g., RPE65. The promoter is one that can express the gene product in the RPE cells. Compositions for subretinal administration are useful in this method. | 10-28-2010 |
20120225930 | METHOD OF TREATING OR RETARDING THE DEVELOPMENT OF BLINDNESS - A method for treating an ocular disorder characterized by the defect or absence of a normal gene in the ocular cells of a human or animal subject involves administering to the subject by subretinal injection an effective amount of a recombinant adeno-associated virus carrying a nucleic acid sequence encoding the normal gene under the control of a promoter sequence which expresses the product of the gene in the ocular cells. The ocular cells are preferably retinal pigment epithelial (RPE) cells, and the gene is preferably an RPE-specific gene, e.g., RPE65. The promoter is one that can express the gene product in the RPE cells. Compositions for subretinal administration are useful in this method. | 09-06-2012 |
Gustavo D. Aguirre, Philadelphia, PA US
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20090176225 | DIAGNOSTIC TEST FOR COLLIE EYE ANOMALY - The invention relates to a method for identifying dogs which are genetically normal, heterozygous for, or homozygous for the mutation primarily responsible for Collie eye anomaly (CEA). The method comprises the steps of obtaining a biological sample from a dog and testing DNA in the biological sample for the presence or absence of a 7.8 kilobase deletion within chromosome 37 in which the CEA mutation is located. No deletion is indicative of a normal dog. A deletion on one allele of chromosome 37 is indicative of a dog that is heterozygous for the CEA mutation. A deletion in both alleles of chromosome 37 are indicative of a dog that is homozygous for the CEA mutation. Also provided is a kit for identifying a dog as normal, heterozygous for, or homozygous for the CEA mutation. | 07-09-2009 |
20130216500 | METHOD OF TREATING OR RETARDING THE DEVELOPMENT OF BLINDNESS - A method for treating an ocular disorder characterized by the defect or absence of a normal gene in the ocular cells of a human or animal subject involves administering to the subject by subretinal injection an effective amount of a recombinant adeno-associated virus carrying a nucleic acid sequence encoding the normal gene under the control of a promoter sequence which expresses the product of the gene in the ocular cells. The ocular cells are preferably retinal pigment epithelial (RPE) cells, and the gene is preferably an RPE-specific gene, e.g., RPE65. The promoter is one that can express the gene product in the RPE cells. Compositions for subretinal administration are useful in this method. | 08-22-2013 |
20140377224 | Method of Treating or Retarding the Development of Blindness - A method for treating an ocular disorder characterized by the defect or absence of a normal gene in the ocular cells of a human or animal subject involves administering to the subject by subretinal injection an effective amount of a recombinant adeno-associated virus carrying a nucleic acid sequence encoding the normal gene under the control of a promoter sequence which expresses the product of the gene in the ocular cells. The ocular cells are preferably retinal pigment epithelial (RPE) cells, and the gene is preferably an RPE-specific gene, e.g., RPE65. The promoter is one that can express the gene product in the RPE cells. Compositions for subretinal administration are useful in this method. | 12-25-2014 |
20150202269 | AAV-MEDIATED GENE THERAPY FOR RPGR X-LINKED RETINAL DEGENERATION - Described herein are methods of preventing, arresting progression of or ameliorating vision loss and other conditions associated with retinitis pigmentosa and x-linked retinitis pigmentosa in a subject. The methods include administering to said subject an effective concentration of a composition comprising a recombinant adeno-associated virus (AAV) carrying a nucleic acid sequence encoding a normal retinitis pigmentosa GTPase regulator (RPGR gene), or fragment thereof, under the control of regulatory sequences which express the product of the gene in the photoreceptor cells of the subject, and a pharmaceutically acceptable carrier. | 07-23-2015 |
Ian Aguirre, Peoria, IL US
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20140154159 | Engine Exhaust Aftertreatment Component Including Aftertreatment Brick Module - An engine exhaust aftertreatment component includes a housing defining an exhaust flow path from an exhaust inlet to an exhaust outlet. The housing supports an internal support channel. An aftertreatment brick module includes a catalytic brick, a can configured to receive the catalytic brick, and an end plate disposed along an end of the can. The end plate includes a coupling mechanism configured to be received within the internal support channel. | 06-05-2014 |
20140248186 | System and Method for Accommodating Aftertreatment Bricks - An aftertreatment system and method treats exhaust gasses produced by an internal combustion process or a similar process. The aftertreatment system includes an aftertreatment module having a sleeve extending between a first end and a second end. One or more aftertreatment bricks are axially inserted into a sleeve opening disposed in the first end of the sleeve. To prevent the aftertreatment bricks from unintentionally exiting the sleeve, a captive ring is disposed around the first end of the sleeve as a loose fitting collar. The captive ring is restrained on the sleeve by a circumferential bead protruding about the first end. The captive ring can couple with a retention ring placed adjacent the first end. When coupled to the captive ring, a portion of the retention ring extends partially across and blocks the sleeve opening, preventing the aftertreatment brick from exiting the sleeve. | 09-04-2014 |
20140283528 | Aftertreatment Module and Method of Assembly - To assemble an aftertreatment module for use in the treatment of exhaust gasses and the like, an aftertreatment brick is inserted into a sleeve opening in a sleeve and advanced toward an opposite end of the sleeve. To retain the aftertreatment brick in the sleeve, the end of the sleeve can include a stop flange and the aftertreatment brick can include a mantle flange. The stop flange and the mantle flange can abut against each other to prevent further movement of the aftertreatment brick through the sleeve. To seal against exhaust gasses leaking though the module, a gasket can be disposed between the stop flange and the mantle flange. Exterior ribs disposed around the aftertreatment brick can assist concentric alignment between the flanges and gasket. | 09-25-2014 |
Javier R. Aguirre, Denville, NJ US
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20090286630 | Soccer training device - A soccer training device for enhancing ball-handling and physical coordination of a soccer player, includes a base member, a rotary member, an elongated arm having a free distal end and a proximal end pivotally attached to a top portion of the base member via the rotary bearing, wherein the elongated arm is adapted for pivotal movement in at least one axis of direction about the point of attachment, an articulated member extending from the distal end of the elongated arm, wherein the articulated member is adapted for movement from a rest position in any axis of direction independent of the elongated arm, a biasing mechanism operatively associated with the articulated member for biasing the articulated member into alignment with the elongated arm, and a ball retaining member operatively associated with the free end of the articulated member for retaining a soccer ball thereon. | 11-19-2009 |
Jesus Aguirre, New Brighton, MN US
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20140263108 | MODULAR STACKABLE EQUIPMENT RACK - A stackable equipment rack system, including separate modular racks, that enables equipment to be mounted in the rack system continuously along the entire height of the rack system, including at the junction between the stacked racks. | 09-18-2014 |
Johnni M. Aguirre, Bellevue, WA US
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20140115655 | SYSTEMS AND METHODS FOR THE RAPID DEPLOYMENT OF NETWORK SECURITY DEVICES - A configuration service comprises a deployment package and a production configuration for a network security device. One or more configuration parameters of the production configuration may be defined by an administrator of the network security device (e.g., the customer). The network security device may be preconfigured with a network address and identifier. The network security device may be configured to automatically request and apply the deployment package at deployment time by use of the preconfigured network address and identifier. The network security device may automatically request and apply the production configuration from the configuration service in response to applying the deployment package. | 04-24-2014 |
20140351882 | SYSTEMS AND METHODS FOR THE RAPID DEPLOYMENT OF NETWORK SECURITY DEVICES - A configuration service comprises a deployment package and a production configuration for a network security device. One or more configuration parameters of the production configuration may be defined by an administrator of the network security device (e.g., the customer). The network security device may be preconfigured with a network address and identifier. The network security device may be configured to automatically request and apply the deployment package at deployment time by use of the preconfigured network address and identifier. The network security device may automatically request and apply the production configuration from the configuration service in response to applying the deployment package. | 11-27-2014 |
Juan Ignacio Aguirre, East Greenwich, RI US
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20080302848 | Variable outward clinch stapler - A pneumatically operated stapler that has a single selectively operable adjuster operatively associated with a staple leg diverter. The single selectively operable adjuster is constructed and arranged to be adjusted within a range of leg deflecting positions to affect the lateral movement of the staple leg diverter. The different leg deflective positions effects an amount to which the diverter will deflect the legs of the driven staple during a drive stroke. A single operation of the single selectively operable adjuster both moves the adjuster and retains the adjuster in an adjusted position within the range of leg deflecting positions. | 12-11-2008 |
20100140314 | FASTENER DRIVING DEVICE - A fastener driving device includes a nose assembly carried by a housing that has a reservoir. The nose assembly has a fastener drive track. At least a portion of the fastener drive track is defined by a movable portion of the nose assembly. A fastener driver is movably mounted in the housing and configured to enter the drive track and drive successive leading fasteners into a workpiece. A head valve is constructed and arranged to be actuated so as to allow the pressurized gas to move the fastener driver through an operating cycle. An actuator is constructed and arranged to actuate the head valve. The actuator includes a trigger valve constructed and arranged to allow passage of the pressurized gas from the reservoir to a chamber above the head valve, and a contact valve operatively connected to the movable portion of the nose assembly. | 06-10-2010 |
Maria V. Aguirre, Jensen Beach, FL US
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20110056505 | HAIR BRUSH - A multi-functional hair brush comprising an elongate body including a handle segment and a bristle segment. The bristle segment of the multi-functional hair brush includes at least two types or styles of bristles, each performing a separate and different function in styling hair. In one embodiment, the multi-functional hair brush includes a round brush bristled in two different ways to perform two different functions. The two different brislings may include first bristles on a first half of the round brush to start and straighten a difficult hair, and second bristles on a second and opposite half of the round brush to finish styling the hair. In another embodiment, the handle segment of the hair brush includes an off-set handle. The off-set handle provides improved feel and comfort in handling the hair brush while styling hair. | 03-10-2011 |
Melvin Aguirre, Madison, WI US
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20140342724 | WIRELESS NETWORK DESIGN, COMMISSIONING, AND CONTROLS FOR HVAC, WATER HEATING, AND LIGHTING SYSTEM OPTIMIZATION - Methods, devices, and systems for commissioning and programming a network of wireless devices are disclosed herein. These can include utilizing a commissioning tool having a directional radio frequency antenna, a microprocessor, and memory. The commissioning tool can function with a Smartphone, or be a stand-alone device. The commissioning tool can program wireless devices without direct physical access or direct line-of-sight from the commissioning tool to the device. The commissioning tool can establish network connections with a “query,” “wink,” “ping” protocol, connecting devices that control HVAC, water heating, and lighting systems wirelessly with a border router that can be for upload data collected by devices to the Internet. The method can also include collection, analysis, and illustrations of building system performance data on web-based software. | 11-20-2014 |
Milton Aguirre, State College, PA US
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20100075170 | POLYCRYSTALLINE COMPLEX-SHAPED MESOSCALE COMPONENTS - A polycrystalline mesoscale component is provided that has an overall length L divided into multiple segments with a second segment extending from a first segment at a nonlinear angle. The first segment has a first segment height H | 03-25-2010 |
Nicole Aguirre, Seattle, WA US
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20160070356 | PHYSICALLY INTERACTIVE MANIFESTATION OF A VOLUMETRIC SPACE - A “PiMovs System” provides a “physically interactive manifestation of a volumetric space” (i.e., PiMovs). The perimeter of a geometric framework is wrapped with contiguous display surfaces to cover each section of the perimeter with adjacent display surfaces. Additional contiguous display surfaces may cover top and/or bottom surfaces of the framework, with some edges of those display surfaces also adjacent edges of display surfaces on the perimeter. Sensors track positions and natural user interface (NUI) inputs of users within a predetermined zone around the framework. A contiguous volumetric projection is generated and displayed over the framework via the display surfaces as a seamless wrapping across each edge of each adjacent display surface. This volumetric projection is then automatically adapted to tracked user positions and NUI inputs. | 03-10-2016 |
Tito Aguirre, Independence, OR US
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20090165603 | Pliers device for changing light bulb in physically constrained location - A light bulb holding pliers device having movably coupled longitudinal members. A handle region may be provided at one end of the longitudinal members and a bulb gripping or holding structure may be provided at the other end. The holding structure may include a frame having at least three points of contact and a compressive material may extend inwardly of a frame, towards the other frame. A releasable locking mechanism permits the device to be clamped to a light bulb to hold it securely without breaking it. The device of the present invention is particularly useful in changing light bulbs in constrained areas, such a motor vehicle dashboards and the like. The longitudinal member may be long and narrow to facilitate this task. | 07-02-2009 |