Agard
Darla Renae Agard, Eagan, MN US
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20090265380 | SYSTEMS AND METHODS FOR TABLES OF CONTENTS - To address problems related to use and formation of tables of contents, the present inventors, devised among other things, an exemplary table-of-contents (TOC) data structure and related systems and methods. One exemplary method entails associating a node from one TOC with a node of another TOC and then assigning a unique identifier to the associated pair of nodes. The unique identifier can then be used to logically define another TOC that includes portions of the two original TOCs. Another exemplary method entails tagging or associating nodes of a TOC with one or more view labels. (Identifiers for node relationships rather than the nodes themselves are tagged with the labels in some embodiments.) | 10-22-2009 |
20120072450 | SYSTEMS, METHODS AND SOFTWARE FOR RESEARCHING STATUTORY INFORMATION - With conventional print and electronic tools, researching statutory material is difficult and time-consuming. So, to facilitate this type of research, the present inventors devised systems, methods, and software that promise to improve the ability of researchers to find, verify, read, and/or interpret statutory information. One exemplary system provides options for users to access statutory information by citation, by table of contents, by index, and/or by popular name; presents specific statutory information in combination with visual indicators, such as red or yellow flags, that indicate the validity or status of the information; and provides requested statutory information in context of links to related information, such as tables of contents, other versions of a statute, case law, scholarly materials, legislative history, cross-referenced statutes, and administrative-law materials. | 03-22-2012 |
20140089350 | SYSTEMS AND METHODS FOR TABLES OF CONTENTS - To address problems related to use and formation of tables of contents, the present inventors, devised among other things, an exemplary table-of-contents (TOC) data structure and related systems and methods. One exemplary method entails associating a node from one TOC with a node of another TOC and then assigning a unique identifier to the associated pair of nodes. The unique identifier can then be used to logically define another TOC that includes portions of the two original TOCs. Another exemplary method entails tagging or associating nodes of a TOC with one or more view labels. (Identifiers for node relationships rather than the nodes themselves are tagged with the labels in some embodiments.) | 03-27-2014 |
David A. Agard, Burlingame, CA US
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20110134552 | METHOD AND APPARATUS FOR CORRECTING OPTICAL ABERRATIONS USING A DEFORMABLE MIRROR - A method and apparatus for correcting optical aberrations in an optical device using a deformable mirror. An actuator is provided which applies a deforming force to the deformable mirror. By selecting particular thickness profiles of the deformable mirror and force configurations of the actuator, the optical device can be configured to correct for different optical aberrations. The actuator may be configured to apply the deforming force peripherally, centrally, non-centrally or homogenously across the surface of the deformable mirror. The deformable mirror may be a flat disk mirror, a convex mirror, or a concave mirror, and may include a membrane having a variable flexibility. The optical device may be a wide-field microscope, an optical read/write device, laser tweezers, or any other optical device in which correction of optical aberrations is desirable. | 06-09-2011 |
20120026311 | STRUCTURED ILLUMINATION MICROSCOPE APPARATUS AND AN IMAGE FORMING APPARATUS - Polarized light which is emitted from an optical fiber becomes circular polarized light bypassing through a first quarter wave plate. The circular polarized light which has entered a second quarter wave plate is converted into nearly linear polarized light which has S polarization. P polarization components are removed from the nearly linear polarized light by a polarizer, but the polarizer is not always necessary. The optical axis of the polarizer is set to be a direction which allows transmitting of S polarized light. The light that has passed through the polarizer is separated into diffracted lights by a diffraction grating, and is used as the structured illumination light. | 02-02-2012 |
Nicholas Agard, San Francisco, CA US
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20130302859 | Engineered imine reductases and methods for the reductive animation of ketone and amine compounds. - The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds. | 11-14-2013 |
20140051119 | FUNGAL BETA-XYLOSIDASE VARIANTS - The present invention provides fungal xylanase and/or beta-xylosidase enzymes suitable for use in saccharification reactions. The present application further provides genetically modified fungal organisms that produce xylanase and/or beta-xylosidases, as well as enzyme mixtures exhibiting enhanced hydrolysis of cellulosic material to fermentable sugars, enzyme mixtures produced by the genetically modified fungal organisms, and methods for producing fermentable sugars from cellulose using such enzyme mixtures. | 02-20-2014 |
Nicholas J. Agard, San Francisco, CA US
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20140314843 | ENGINEERED PHENYLALANINE AMMONIA LYASE POLYPEPTIDES - The present invention provides engineered phenylalanine ammonia-lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (PAL) polypeptides. | 10-23-2014 |
20150017696 | RECOMBINANT HOST CELLS AND PROCESSES FOR PRODUCING 1,3-BUTADIENE THROUGH A CROTONOL INTERMEDIATE - The present disclosure relates to recombinant host cells comprising one or more recombinant polynucleotides encoding enzymes in select pathways that provide the ability to use the cells to produce 1,3-butadiene. The present disclosure also provides methods of manufacturing the recombinant host cells, and methods for the use of the cells to produce 1,3-butadiene, either through formation of the intermediate compound crotonol followed by chemo-catalytic dehydration to 1,3-butadiene, or through the use of a recombinant cell comprising a fully enzymatic pathway capable of converting crotonyl-CoA or crotonyl-ACP to crotonol and then crotonol to 1,3-butadiene. | 01-15-2015 |
Nicholas John Agard, San Francisco, CA US
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20140017733 | FUNGAL XYLANASES AND XYLOSIDASES - The present invention provides fungal xylanase and/or xylosidase enzymes suitable for use in saccharification reactions. The present invention provides xylanase and xylosidase enzymes suitable for use in saccharification reactions. The present application further provides genetically modified fungal organisms that produce xylanase(s) and/or xylosidase(s), as well as enzyme mixtures exhibiting enhanced hydrolysis of cellulosic material to fermentable sugars, enzyme mixtures produced by the genetically modified fungal organisms, and methods for producing fermentable sugars from cellulose using such enzyme mixtures. In some embodiments, the xylanase and xylosidase enzyme(s) are | 01-16-2014 |
20140221216 | METHODS, SYSTEMS, AND SOFTWARE FOR IDENTIFYING BIO-MOLECULES USING MODELS OF MULTIPLICATIVE FORM - The present invention provides methods for identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. More specifically, some embodiments of the present invention provide methods for building sequence-activity models comprising multiplicative terms and using the models to guide directed evolution. In some embodiments, the sequence-activity models include one or more interaction terms, each of which including an interaction coefficient representing the contribution to activity of two or more defined residues. In some embodiments, the models describe relation between protein or nucleic acid sequences and protein activities. In some embodiments, the present invention also provides methods for preparing sequence-activity models, including but not limited to stepwise addition or subtraction techniques, Bayesian regression, ensemble regression and other methods. The present invention further provides digital systems and software for performing the methods provided herein. | 08-07-2014 |
20140342414 | DIRECT BIOCATALYTIC PRODUCTION OF ACRYLIC ACID AND OTHER CARBOXYLIC ACID COMPOUNDS - The present disclosure relates to biocatalytic methods or processes for the synthesis of acrylic acid and its derivatives, or other carboxylic acid compounds of the formula R—CO2H, wherein R is a carbon chain of 5 carbons or fewer, such as methacrylic acid or 3-hydroxypropionic acid. More specifically, the disclosure relates to methods of using an acyl-CoA hydrolase (such as a thioesterase) as a biocatalyst for the hydrolysis (and removal of the CoA moiety) of a substrate acyl-CoA compound to produce the corresponding carboxylic acid compound, such as acrylic acid. In some embodiments, the disclosure provides non-naturally occurring microorganisms that have been transformed with a heterologous acyl-CoA hydrolase, such as a thioesterase, that is capable of hydrolyzing an acyl-CoA produced in a pathway of the microorganism and produce the corresponding carboxylic acid compound, thereby allowing methods for the direct fermentative production of the compound. | 11-20-2014 |
Ryan Agard, Royersford, PA US
Patent application number | Description | Published |
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20120316507 | Biomaterial Dispensing Device - A device for dispensing biomaterial includes a handle configured to receive a syringe, the syringe including a biomaterial and a threaded plunger, and an engagement pin retained within the handle and slidable between a first position and a second position. The engagement pin is configured to engage the threaded plunger in the first position, the engagement pin is further configured to disengage from the threaded plunger in the second position. | 12-13-2012 |
20130060337 | Spinal Plate - Spinal plates with additional features to improve the stability of the interface between the plate and the underlying bone. A bone plate may include one or more sharp ridges along the periphery of its underside. When attached to bone, the ridge digs into the bone and increases stability. A bone plate may alternatively or additionally include one or more holes for optional spikes, which may be inserted once the plate is attached to the bone. By separating the spikes and including them as an optional component, the plate may enhance stability while reducing or eliminating the chance of the spike injuring the patient. Furthermore, bone screws may incorporate alternating notches and ridges into the head of the screw. The notches and ridges may interface with a set screw, thereby preventing rotation and loosening of the screw. | 03-07-2013 |
20130197551 | Surgical Disc Removal Tool - The disclosure provides a tissue removal device including customizable tips. The tissue removal device may include an outer shaft and a threaded shaft. One aspect of disclosure may include a shaft cutting tool that emerges from the end of the outer shaft. Another aspect of the disclosure may include a flexible cutting blade extending from the threaded shaft. Threaded shaft may be driven by a driving mechanism in order to provide an auger-like suction mechanism to facilitate the transfer of removed tissue to a collection chamber that is coupled to the outer shaft and the threaded shaft. | 08-01-2013 |
20140039449 | Biomaterial Dispensing Device - A device for dispensing biomaterial includes a handle configured to receive a syringe, the syringe including a biomaterial and a threaded plunger, and an engagement pin retained within the handle and slidable between a first position and a second position. The engagement pin is configured to engage the threaded plunger in the first position, the engagement pin is further configured to disengage from the threaded plunger in the second position. | 02-06-2014 |
20140081286 | Surgical Disc Removal Tool - The disclosure provides a tissue removal device including customizable tips. The tissue removal device may include an outer shaft and a threaded shaft. One aspect of disclosure may include a shaft cutting tool that emerges from the end of the outer shaft. Another aspect of the disclosure may include a flexible cutting blade extending from the threaded shaft. Threaded shaft may be driven by a driving mechanism in order to provide an auger-like suction mechanism to facilitate the transfer of removed tissue to a collection chamber that is coupled to the outer shaft and the threaded shaft. | 03-20-2014 |
20140316427 | Surgical Disc Removal Tool - The disclosure provides a tissue removal device including customizable tips. The tissue removal device may include an outer shaft and a threaded shaft. One aspect of disclosure may include a shaft cutting tool that emerges from the end of the outer shaft. Another aspect of the disclosure may include a flexible cutting blade extending from the threaded shaft. Threaded shaft may be driven by a driving mechanism in order to provide an auger-like suction mechanism to facilitate the transfer of removed tissue to a collection chamber that is coupled to the outer shaft and the threaded shaft. | 10-23-2014 |
Ryan Agard, Media, PA US
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20150105786 | BIOMATERIAL DISPENSING DEVICE - A device for dispensing biomaterial includes a handle configured to receive a syringe, the syringe including a biomaterial and a threaded plunger, and an engagement pin retained within the handle and slidable between a first position and a second position. The engagement pin is configured to engage the threaded plunger in the first position, the engagement pin is further configured to disengage from the threaded plunger in the second position. | 04-16-2015 |
Ryan M. Agard, Royersford, PA US
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20130237916 | FILL-FINISH CARTRIDGES FOR STERILE FLUID PATHWAY ASSEMBLIES AND DRUG DELIVERY DEVICES INCORPORATING FILL-FINISH CARTRIDGES - A fluid pathway assembly includes a needle insertion mechanism, a fluid conduit, and a fluid pathway connection. The fluid pathway assembly may further include a drug container to hold a drug fluid prior to initiation of the injection. The assembly may include a carrier disposed along at least a portion of the fluid pathway assembly, and/or a drug container. The fill-finish cartridge functions to retain the components of the fluid pathway assembly in a sterile condition, while allowing for easy integration of the fluid pathway assembly and the drug container into a standard fill-finish process. Methods of constructing a cartridge, filling a drug container included in a cartridge, and incorporating the same into a drug delivery device are disclosed. | 09-12-2013 |
20140200510 | DRIVE MECHANISM FOR DRUG DELIVERY PUMPS WITH INTEGRATED STATUS INDICATION - A drive mechanism includes a housing, a piston adapted to impart movement to a plunger seal within a drug container, a plurality of biasing members disposed in parallel, and a retainer. The biasing members are disposed to release energy to cause movement of the piston from a retracted first position to the extended second position, the piston bearing against the plunger seal to dispense medicine. The retainer is disposed to maintain the biasing members in the energized position and to release the biasing members to permit the piston to dispense the medicine. The drive mechanism may also include an end-of-dose indicator to identify at least one of when the sleeve assembly is disposed subjacent a window in the housing, the relative motion of the sleeve assembly with reference to the window or another reference component, the stoppage of such motion, and the rated or change of rate of motion. | 07-17-2014 |
20140213975 | INTEGRATED SLIDING SEAL FLUID PATHWAY CONNECTION AND DRUG CONTAINERS FOR DRUG DELIVERY PUMPS - A fluid pathway connection includes a piercing member, a connection hub, and a sliding pierceable seal, wherein the sliding pierceable seal is configured to move from a first position, where the piercing member is initially retained within a sterile cavity between the connection hub and the sliding pierceable seal, to a second position, where the pierceable seal has been penetrated by the piercing member. A filter may be utilized to enclose the sterile cavity from the outside environment. The fluid pathway connection may further be configured to move to a third position where one or more interconnects and/or one or more corresponding contacts are permitted to transmit a signal to the user. Such fluid pathway connections may be integrated into a drug container having a barrel and a plunger seal. A drug delivery pump includes such integrated fluid pathway connections and drug containers. | 07-31-2014 |
20140296787 | DRIVE MECHANISM FOR DRUG DELIVERY PUMPS WITH INTEGRATED STATUS INDICATION - A drive mechanism includes a housing, a piston adapted to impart movement to a plunger seal within a drug container, a plurality of biasing members disposed in parallel, and a retainer. The biasing members are disposed to release energy to cause movement of the piston from a retracted first position to the extended second position, the piston bearing against the plunger seal to dispense medicine. The retainer is disposed to maintain the biasing members in the energized position and to release the biasing members to permit the piston to dispense the medicine. The drive mechanism may also include an end-of-dose indicator to identify at least one of when the sleeve assembly is disposed subjacent a window in the housing, the relative motion of the sleeve assembly with reference to the window or another reference component, the stoppage of such motion, and the rated or change of rate of motion. | 10-02-2014 |