Patent application number | Description | Published |
20090325222 | Tissue Sample Preparation and MALDI MS Imaging Thereof - Aspects of the present invention relate to a method for the preparation of samples for MALDI MS imaging. Certain embodiments relate to a method of matrix deposition for samples, wherein tissue sections are prepared via a synergistic combination of fixation with matrix. In certain embodiments, tissue is fixed with cold solvent, according to well-established histology protocols, and in the presence of matrix, allowing for high resolution spatial mapping of protein, lipid, sugar, and/or nucleic acid distribution. In certain embodiments, the present invention relates to fixation with matrix of whole organisms. In certain embodiments, animals are perfused with fixation and matrix mixtures, which allows for direct mass spectrometry analysis. | 12-31-2009 |
20100152125 | Compositions And Methods For The Diagnosis, Treatment, And Prevention Of Amyotrophic Lateral Sclerosis And Related Neurological Diseases - One aspect of the invention relates to a method of treating or preventing a neurodegenerative disease, comprising the step of administering to a patient in need thereof a therapeutically effective amount of an inhibitor of the formation of advanced glycation end products. Another aspect of the invention relates to a proteasome activity-based screening assay to select compounds which may be useful for treating or preventing a neurodegenerative disease, and the materials used therein. Yet another aspect of the invention relates to molecules, and methods of use thereof, which bind at or adjacent to SOD-I Trp32, including molecules that bind in a site adjacent to SOD-I Trp32 whether or not it is oxidized, for treating or preventing neurodegenerative disease. | 06-17-2010 |
20120134978 | Cross-Linking of Superoxide Dismutase Monomers - A stabilized superoxide dismutase (SOD1) analogue, wherein the side chains of two amino acids on two different SOD1 monomers are connected is provided. A method of producing a stabilized superoxide disumutase (SOD1) analogue comprises reacting a first SOD1 monomer, a second SOD1 monomer, and a cross-linker. | 05-31-2012 |
20150284478 | Tethering Cysteine Residues Using Cyclic Disulfides - Described herein are compounds and methods for tethering proteins. For example, dimers of proteins, including SOD1 and DJ-1, are described, where the dimers are formed by the covalent bonding of a cysteine on the first monomer to a cysteine on the second monomer via a cyclic disulfide linker. The covalently attached dimers exhibit increased stabilization. | 10-08-2015 |
20150300930 | Tissue Sample Preparation, and MALDI MS Imaging Thereof - Aspects of the present invention relate to a method for the preparation of samples for MALDI MS imaging. Certain embodiments relate to a method of matrix deposition for samples, wherein tissue sections are prepared via a synergistic combination of fixation with matrix. In certain embodiments, tissue is fixed with cold solvent, according to well-established histology protocols, and in the presence of matrix, allowing for high resolution spatial mapping of protein, lipid, sugar, and/or nucleic acid distribution. In certain embodiments, the present invention relates to fixation with matrix of whole organisms. In certain embodiments, animals are perfused with fixation and matrix mixtures, which allows for direct mass spectrometry analysis. | 10-22-2015 |
Patent application number | Description | Published |
20120278816 | APPARATUS, AND ASSOCIATED METHOD, FOR FORMING A MEDIA PLAY-OUT LIST - An apparatus, and an associated method, forms a media play-out list of media, selected from a media database. A temporal indication is provided, and an estimated event is estimated based upon the temporal information. Indication of the estimated event is correlated with metadata of media stored at the media database. Media corresponding to metadata that correlates well with the estimated event is amenable for inclusion in the media play-out list. | 11-01-2012 |
20120331287 | Provisioning a Shared Secret to a Portable Electronic Device and to a Service Entity - Systems and methods are provided for computing a secret shared with a portable electronic device and service entity. The service entity has a public key G and a private key g. A message comprising the public key G is broadcast to the portable electronic device. A public key B of the portable electronic device is obtained from a manufacturing server and used together with the private key g to compute the shared secret. The portable electronic device receives the broadcast message and computes the shared secret as a function of the public key G and the portable electronic device's private key b. The shared secret can be used to establish a trusted relationship between the portable electronic device and the service entity, to activate a service on the portable electronic device, and to generate certificates. | 12-27-2012 |
20130176333 | INTERFACE FOR PREVIEWING IMAGE CONTENT - What is disclosed is a novel method and system to present image content from a variety of informational sources. Presentation from a variety of image sizes and formats, such as standard and panoramic format is possible. The method includes accessing at least two information sources each with separate image content. Next, each of the separate image content is interspersed in an arrangement so that content overlaps in with each other and at least some of the image content is automatically resized to concurrently present image content in a plurality of different image sizes and in a film strip arrangement. The image content is presented from each of the information sources along with the source indicator in a film strip arrangement. | 07-11-2013 |
20130287230 | Apparatus and Method Pertaining to Volume Control - An apparatus comprises a volume-control user interface, a transmitter, an audio amplifier (having a corresponding amplification range), and a control circuit operably coupled to the foregoing components. This control circuit is configured to respond to a volume change made via the volume-control user interface that is within the amplification range of the audio amplifier by making a corresponding change to a volume level for an audio signal being transmitted by the transmitter. The control circuit is also configured to respond to a volume change made via the volume-control user interface that exceeds the amplification range of the audio amplifier by transmitting a volume-increase command. | 10-31-2013 |
Patent application number | Description | Published |
20100280757 | Multi-Phase Fluid Measurement Apparatus and Method - The present disclosure provides a flowmeter including a vibrating element configured to be inserted in a measured fluid; a driver circuit to vibrate the vibrating element in its natural frequency of oscillation; one or more additional technology flow meters configured to measure an additional property of the fluid; a data acquisition circuit configured to measure signals effected by the flow of a multi-phase fluid; and a computer suitable to solve non-linear simultaneous equations. The fluid may include gas, oil and/or water. The fluid may also include solids. | 11-04-2010 |
20130036588 | Method and Apparatus for Installing a Device at a Storage Vessel - A method and apparatus for installing a device in a storage vessel having a drawline while the storage vessel is in operation is disclosed. A cutting tool is run through the drawline from a distal location to a location inside the storage vessel. The cutting tool is used to create an opening in the drawline at the location inside the storage vessel. The device is installed at the created opening. | 02-14-2013 |
20140136125 | SYSTEM AND METHOD FOR MULTI-PHASE FLUID MEASUREMENT - The flow meter system includes flow meters taking measurements based on a set of parameters of a multiphase fluid, each measurement corresponding to respective groups of interrelated unknown variables. These unknown variables are selected from the set of parameters, and the groups of unknown variables are different from each other. A processor uses an iterative process to solve equations of a mathematical model, determined by the equations corresponding to the measurements and groups of unknown variables, so as to estimate an amount of a target unknown variable selected from the set of parameters. The method for estimating a target unknown variable of a multiphase fluid includes installing flow meters in the multiphase fluid; taking measurements based on a set of parameters; determining a mathematical model with equations corresponding to the measurements and groups of interrelated unknown variables; and solving equations with an iterative process. | 05-15-2014 |
20150059446 | METHOD AND SYSTEM FOR ANALYSIS OF RHEOLOGICAL PROPERTIES AND COMPOSITION OF MULTI-COMPONENT FLUIDS - A method and system for on-line multi-component fluid analysis, the system can be configured to measure the absolute viscosity using data acquired by monitoring the flow rate or pump rate and pressure at the discharge for a reference fluid and the flow rate or pump rate and pressure at the discharge for a sample fluid. The system and method can also include comparing the data acquired for the sample fluid and the reference fluid. The system and method can present rheological behavior of the sample fluid as Newtonian viscosity and the shear rate in real time. | 03-05-2015 |
Patent application number | Description | Published |
20110144476 | Integrated Surgical Sampling Probe - The present invention is directed to devices for collecting tissue samples from patients. The devices create tissue fragments which are then collected by aspiration. The devices include signal emitters that allow the exact position where a biopsy sample was obtained to be determined. In addition the invention includes methods for obtaining tissue samples using these devices. | 06-16-2011 |
20110192974 | Preparation of Test Plates for Matrix Assisted Laser Desorption Ionization - The present invention is directed, sample test plates that can be used in matrix assisted laser desorption ionization. These plates have an etched surface and a layer of MALDI matrix material. The invention also includes methods for making these sample test plates and to methods for using the plates in the MS imaging of cell and tissue samples. | 08-11-2011 |
20120080592 | METHOD AND SYSTEM FOR SURFACE SAMPLING - A system and sampling probe adaptable to an ultrasonic surgical instrument applies irrigation fluid and ultrasonic or vibrational energy to a target, and aspirates material desorbed from the target into a pick-up conduit. A suction source at the distal end of the conduit may aspirate the material released from the target with the irrigation fluid, thus efficiently sampling a broad range of materials from an arbitrary target to produce an analyzable effluent analyte stream which may be ionized and provided to the inlet of an ion-type analysis instrument, or may be fed directly to an instrument such as a flow cytometer, IR or fluorescence spectrophotometer, or other analyzer. Carrier gas may be provided to more effectively transport the desorbed material, and the probe may be incorporated into a robotic device to automatically carry out surface imaging or to effect sampling in hazardous environments. | 04-05-2012 |
Patent application number | Description | Published |
20130131832 | Method and Apparatus For Analogue Output Current Control - This invention relates to an apparatus and method for output current control in an Industrial Process Control System. The output module comprises two management units each of which calculates the current demand for the module independently from one another. One management unit controls an output current controller whilst the other unit monitors the current produced by the output current controller against an independently calculated demand. The output module has multiple output modules. However rather than one module providing a backup for the other modules, or alternating between use of each module, in normal operation, each module provides a portion of the required output current, the total output current being equal to the sum of the currents output by each module. In the event of failure on one of the modules, the other module or modules switch to providing the total current required and the failed module is switched to a fail safe mode by using an isolation circuit to switch off the output current from that module. | 05-23-2013 |
20130131834 | Method and Apparatus For Analogue Output Current Control - This invention relates to an apparatus and method for output current control in an Industrial Process Control System. The output module comprises two management units each of which calculates the current demand for the module independently from one another. One management unit controls an output current controller whilst the other unit monitors the current produced by the output current controller against an independently calculated demand. The output module has multiple output modules. However rather than one module providing a backup for the other modules, or alternating between use of each module, in normal operation, each module provides a portion of the required output current, the total output current being equal to the sum of the currents output by each module. In the event of failure on one of the modules, the other module or modules switch to providing the total current required. | 05-23-2013 |
20150103957 | HART Sampling - A method for processing an electrical signal comprises receiving an electrical signal comprising a frequency modulated signal encoding digital data, sampling a first portion of the electrical signal to provide a first sample set, and determining an intermediate value from the first sample set. A first output value is selected from a plurality of stored output values based on the intermediate value, the output value indicating a frequency modulation encoded value within the first portion of the electrical signal. An indication of the obtained output value is output. | 04-16-2015 |
20150263712 | Method and Apparatus for Monitoring a Signal - A method of monitoring an analogue signal output from a sensor comprising comparing the amplitude of the analogue signal to a first high and low threshold, setting a primary monitoring signal to a first value when the amplitude of the analogue signal exceeds the first high threshold, setting the primary monitoring signal to a second value when the amplitude of the analogue signal decreases below the first low threshold, comparing the amplitude of the analogue signal to a second high and low threshold, setting a secondary monitoring signal to a first value when the amplitude of the analogue signal exceeds the second high threshold, setting the secondary monitoring signal to a second value when the amplitude of the analogue signal decreases below the second low threshold, comparing the primary and secondary monitoring signals and determining from the comparison whether an error exists with the monitoring of the analogue signal. | 09-17-2015 |