Patent application number | Description | Published |
20110257709 | METHOD AND APPARATUS FOR MODIFYING NEUROSTIMULATION LINEAR LEAD SHAPE TO CORRECT LEAD MIGRATION - A neurostimulation system comprises an implantable neurostimulation lead, an implantable neurostimulator configured for delivering stimulation energy to the implantable neurostimulation lead, an actuating device configured for modifying a linear shape of the lead after it has migrated from a baseline position, memory configured for storing a threshold value, and a processor configured for determining a magnitude at which the lead has migrated from the baseline position, comparing the determined magnitude to the threshold value, and prompting the actuating device to modify the linear shape of the lead based on the comparison. A method of correcting the migration of a neurostimulation lead implanted within the patient comprises determining a magnitude at which the implanted lead has migrated from a baseline position, comparing the determined magnitude to a threshold value, and modifying the linear shape of the lead based on the comparison. | 10-20-2011 |
20110257710 | METHOD AND APPARATUS FOR ALERTING A USER OF NEUROSTIMULATION LEAD MIGRATION - A neurostimulation system comprises an implantable neurostimulation lead, an implantable neurostimulator configured for delivering stimulation energy to the lead, an indicator configured for outputting a user-discernible alert signal indicating that the lead has migrated from a baseline position, memory configured for storing a threshold value, and a processor configured for determining a magnitude at which the lead has migrated from the baseline position, comparing the determined magnitude to the threshold value, and prompting the indicator to output the alert signal based on the comparison. A method of alerting a user to the migration of a neurostimulation lead implanted within the user comprises determining a magnitude at which an implanted neurostimulation lead has migrated from a baseline position, comparing the determined magnitude to a threshold value, and outputting a user-discernible alert signal indicating that the implanted lead has migrated based on the comparison. | 10-20-2011 |
20110288618 | NEUROSTIMULATION LEAD ANCHORS - In accordance with the present inventions, anchoring devices for a lead (e.g., a neurostimulation lead) placed on solid tissue (e.g., fascia) and methods of anchoring the lead relative to the tissue are provided. Such methods may include inserting the lead into an epidural space and coupling the lead to a neurostimulation. | 11-24-2011 |
20120130398 | SYSTEMS AND METHODS FOR TREATMENT OF DRY EYE - A stimulation system stimulates anatomical targets in a patient for treatment of dry eye. The system may include a controller and a microstimulator. The controller may be implemented externally to or internally within the microstimulator. The components of the controller and microstimulator may be implemented in a single unit or in separate devices. When implemented separately, the controller and microstimulator may communicate wirelessly or via a wired connection. The microstimulator may generate pulses from a controller signal and apply the signal via one or more electrodes to an anatomical target. The microstimulator may not have any intelligence or logic to shape or modify a signal. The microstimulator may be a passive device configured to generate a pulse based on a signal received from the controller. The microstimulator may shape or modify a signal. Waveforms having different frequency, amplitude and period characteristics may stimulate different anatomical targets in a patient. | 05-24-2012 |
20130331912 | METHOD AND APPARATUS FOR ALERTING A USER OF NEUROSTIMULATION LEAD MIGRATION - A neurostimulation system comprises an implantable neurostimulation lead, an implantable neurostimulator configured for delivering stimulation energy to the lead, an indicator configured for outputting a user-discernible alert signal indicating that the lead has migrated from a baseline position, memory configured for storing a threshold value, and a processor configured for determining a magnitude at which the lead has migrated from the baseline position, comparing the determined magnitude to the threshold value, and prompting the indicator to output the alert signal based on the comparison. A method of alerting a user to the migration of a neurostimulation lead implanted within the user comprises determining a magnitude at which an implanted neurostimulation lead has migrated from a baseline position, comparing the determined magnitude to a threshold value, and outputting a user-discernible alert signal indicating that the implanted lead has migrated based on the comparison. | 12-12-2013 |
Patent application number | Description | Published |
20120143296 | PERCUTANEOUSLY IMPLANTABLE PADDLE-TYPE LEAD AND METHODS AND DEVICES FOR DEPLOYMENT - A percutaneously implantable paddle lead includes an elongated lead body having a proximal portion and a distal portion; a plurality of terminals disposed on the proximal portion of the lead; a flexible paddle body coupled to the distal portion of the lead; and a plurality of electrodes disposed in the paddle body and electrically coupled to the terminals on the proximal portion of the lead. The percutaneously implantable paddle lead also includes a bonding material in contact with the paddle body and holding the paddle body in a compacted form prior to, and during, insertion into a percutaneous implantation tool. The bonding material is configured and arranged to release the paddle body during or soon after implantation into a patient so that the paddle body can deploy into its paddle-like form. Alternatively, at least one current-degradable fastener can be used instead of the binding material. | 06-07-2012 |
20120215285 | System for Communication with Implantable Medical Devices Using a Bridge Device - A communications bridge device communicates between a consumer electronics device, such as a smart telephone, and an implantable medical device. The bridge forwards instructions and data between the consumer electronics device and the implantable medical device. The bridge contains a first transceiver that operates according to a communication protocol operating in the consumer electronics device (such as Bluetooth®), and second transceiver that operates according to a communications technique operating in the implantable medical device (e.g., Frequency Shift Keying). A software application is installed on the consumer electronics device, which provides a user interface for controlling and reading the implantable medical device. The software application is downloadable using standard cellular means. The bridge is preferably small, and easily and discreetly carried by the implantable medical device patient. The bridge is preferably also simple to operate, and may have only a simple user interface, or no user interface at all. | 08-23-2012 |
20130006326 | STIMULATION DEVICES AND METHODS - Described here are stimulation systems and methods for stimulating one or more anatomical targets in a patient for treatment conditions such as dry eye. The stimulation system may include a controller and a microstimulator. The components of the controller and microstimulator may be implemented in a single unit or in separate devices. When implemented separately, the controller and microstimulator may communicate wirelessly or via a wired connection. The microstimulator may generate pulses from a signal received from the controller and apply the signal via one or more electrodes to an anatomical target. In some variations, the microstimulator may include a passive generation circuit configured to generate a pulse based on a signal received from the controller. | 01-03-2013 |
20140055741 | CONTACT LENS WITH A HYDROPHILIC LAYER - Embodiments of the technology relate to a contact lens having a core that is covalently coated by a hydrogel layer, and to methods of making such a lens. In one aspect, embodiments provide for a coated contact lens comprising a lens core comprising an outer surface; and a hydrogel layer covalently attached to at least a portion of the outer surface, the hydrogel layer adapted to contact an ophthalmic surface, wherein the hydrogel layer comprises a hydrophilic polymer population having a first PEG species and a second PEG species, the first PEG species being at least partially cross-linked to the second PEG species. | 02-27-2014 |
20140257433 | DEVICES AND METHODS FOR TREATING DRY EYE IN ANIMALS - Described here are devices, systems, and methods for treating a condition in an animal. Generally the systems include a stimulator that is implantable in the animal and a controller system configured to transmit one or more signals to the implanted stimulator. The controller system may have a controller configured to generate the one or more signals. The controller system may include one or more collars, bridles, horse hoods, cages, animal beds, and/or food bowls. The systems may be used to treat one or more conditions such as dry eye, and may treat the conditions in an animal such as a horse, dog, or cat. | 09-11-2014 |
20140277429 | IMPLANT DELIVERY DEVICES, SYSTEMS, AND METHODS - Described here are systems, devices, and methods for delivering an implant to the orbit. In some instances, the systems may comprise a delivery device having a tongue member and a handle. The delivery device may further include an ejector configured to deliver an implant from the tongue member. The delivery device may also include a piercing member configured to create an opening in tissue. The systems may further comprise a piercing member for creating an opening in tissue. In some instances, the piercing member may have a first blade member rotatably connected to a second blade member. | 09-18-2014 |
20140316485 | NASAL STIMULATION DEVICES AND METHODS - Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health. | 10-23-2014 |
20140371812 | NASAL STIMULATION DEVICES AND METHODS - Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health. | 12-18-2014 |
20150088156 | SYSTEMS AND METHODS FOR TREATMENT OF DRY EYE - A stimulation system stimulates anatomical targets in a patient for treatment of dry eye. The system may include a controller and a microstimulator. The controller may be implemented externally to or internally within the microstimulator. The components of the controller and microstimulator may be implemented in a single unit or in separate devices. When implemented separately, the controller and microstimulator may communicate wirelessly or via a wired connection. The microstimulator may generate pulses from a controller signal and apply the signal via one or more electrodes to an anatomical target. The microstimulator may not have any intelligence or logic to shape or modify a signal. The microstimulator may be a passive device configured to generate a pulse based on a signal received from the controller. The microstimulator may shape or modify a signal. Waveforms having different frequency, amplitude and period characteristics may stimulate different anatomical targets in a patient. | 03-26-2015 |
20150182754 | System for Communicating with Implantable Medical Devices Using a Bridge Device - A communications bridge device communicates between a consumer electronics device, such as a smart telephone, and an implantable medical device. The bridge forwards instructions and data between the consumer electronics device and the implantable medical device. The bridge contains a first transceiver that operates according to a communication protocol operating in the consumer electronics device (such as Bluetooth®), and second transceiver that operates according to a communications technique operating in the implantable medical device (e.g., Frequency Shift Keying). A software application is installed on the consumer electronics device, which provides a user interface for controlling and reading the implantable medical device. The software application is downloadable using standard cellular means. The bridge is preferably small, and easily and discreetly carried by the implantable medical device patient. The bridge is preferably also simple to operate, and may have only a simple user interface, or no user interface at all. | 07-02-2015 |
20150335900 | SYSTEMS AND METHODS FOR TREATMENT OF DRY EYE - A stimulation system stimulates anatomical targets in a patient for treatment of dry eye. The system may include a controller and a microstimulator. The controller may be implemented externally to or internally within the microstimulator. The components of the controller and microstimulator may be implemented in a single unit or in separate devices. When implemented separately, the controller and microstimulator may communicate wirelessly or via a wired connection. The microstimulator may generate pulses from a controller signal and apply the signal via one or more electrodes to an anatomical target. The microstimulator may not have any intelligence or logic to shape or modify a signal. The microstimulator may be a passive device configured to generate a pulse based on a signal received from the controller. The microstimulator may shape or modify a signal. Waveforms having different frequency, amplitude and period characteristics may stimulate different anatomical targets in a patient. | 11-26-2015 |
Patent application number | Description | Published |
20120289558 | GAMMA-SECRETASE MODULATORY COMPOUNDS, METHODS FOR IDENTIFYING SAME, AND USES THEREFOR - In accordance with the present invention, it has been discovered that compounds which modulate the γ-secretase enzyme to make more of the shorter, less toxic and less aggregation-prone Aβ peptides (such as Aβ37 and Aβ38), while making less of the longer and more toxic and aggregation-prone AB peptides (such as AB40 and AB42) are useful as gamma-secretase modulators. In addition, these GSM compounds have further been discovered to have the selective property of modulating the formation of various AB peptides, while not inhibiting the overall activity of the γ-secretase enzyme. Thus, such compounds do not impede other critical functions of the γ-secretase enzyme, such as generating fragments from Notch that appear to control gene expression and cell differentiation. Therefore, in accordance with the present invention, there are provided screening assays useful for determining whether test compounds have GSM activity; accordingly, invention assays facilitate the identification of new gamma-secretase modulators. Such screening assays can be performed in a variety of ways, e.g., by assessing whether test compounds: lower the level of Aβ42 peptide, increase the level of Aβ37 and/or Aβ38 peptides, have substantially no effect on the processing of other γ-secretase substrates, and/or interact with at least one component of the γ-secretase complex. Also provided in accordance with the present invention are compounds having gamma-secretase modulatory activity as identified by any of the methods described herein; methods for producing formulations useful for modulating gamma-secretase activity, as well as the resulting formulations; methods for modulating gamma-secretase activity employing compounds identified according to invention methods and/or invention formulations, and the like. | 11-15-2012 |
Patent application number | Description | Published |
20080277531 | Hybrid Composite Panel Systems and Methods - Hybrid composite panel systems and methods are disclosed. In one embodiment, an assembly includes a primary section, a matrix member engaged with the primary section, and a secondary section engaged with the matrix member opposite the primary section. The primary section includes a plurality of first composite layers reinforced with a first reinforcing material, and the secondary section includes a plurality of second composite layers reinforced with a second reinforcing material. The primary and secondary sections are configured to bear an operating load at least partially transversely to the first and second composite layers, and are asymetrically configured such that the primary section bears a majority of the applied operating load. | 11-13-2008 |
20090155524 | COMPOSITE PANEL AND METHOD OF MANUFACTURING THE SAME - A method of manufacturing a composite panel is described. The method includes pre-stabilizing a honeycomb core with at least one layer of a pre-stabilizing material, surrounding the honeycomb core with at least one composite laminate skin layer, and curing the at least one composite laminate skin layer. | 06-18-2009 |
20090283639 | WING TIP JOINT IN AIRFOILS - An aircraft joint comprises a wing structure and a wing tip. The wing structure has a first part of a clevis and lug fastening system located around an outer end of the wing structure. The wing tip has a second part of the clevis and lug fastening system located around an end of the wing tip. The wing tip is capable of being joined to the outer end of the wing structure. An upper aerodynamic surface and a lower aerodynamic surface are formed by joining the wing structure and the wing tip. The first part and the second part are located about a center between the upper aerodynamic surface and the lower aerodynamic surface. The first part and the second part engage each other such that a moment reaction occurs around the upper aerodynamic surface and the lower aerodynamic surface. | 11-19-2009 |
20150203187 | Continuously Curved Spar and Method of Manufacturing - There is provided in an embodiment an airfoil. The airfoil has one or more fuel containment regions disposed in the airfoil and one or more continuously curved spars extending from a root end of the airfoil toward a tip end of the airfoil. At least one continuously curved spar has a unitary configuration, has one or more continuous curves along the continuously curved spar, and either has a portion forming a structural wall of at least one of the one or more fuel containment regions, or, is internal to the one or more fuel containment regions. | 07-23-2015 |
Patent application number | Description | Published |
20120232005 | LIPOPROTEIN COMPLEXES AND MANUFACTURING AND USES THEREOF - The present disclosure relates to lipoprotein complexes and lipoprotein populations and their use in the treatment and/or prevention of dyslipidemic diseases, disorders, and/or conditions. The disclosure further relates to recombinant expression of apolipoproteins, purification of apolipoproteins, and production of lipoprotein complexes using thermal cycling-based methods. | 09-13-2012 |
20140213501 | LIPOPROTEIN COMPLEXES AND MANUFACTURING AND USES THEREOF - The present disclosure relates to lipoprotein complexes and lipoprotein populations and their use in the treatment and/or prevention of dyslipidemic diseases, disorders, and/or conditions. The disclosure further relates to recombinant expression of apolipoproteins, purification of apolipoproteins, and production of lipoprotein complexes using thermal cycling-based methods. | 07-31-2014 |
20150152164 | LIPOPROTEIN COMPLEXES AND MANUFACTURING AND USES THEREOF - The present disclosure relates to lipoprotein complexes and lipoprotein populations and their use in the treatment and/or prevention of dyslipidemic diseases, disorders, and/or conditions. The disclosure further relates to recombinant expression of apolipoproteins, purification of apolipoproteins, and production of lipoprotein complexes using thermal cycling-based methods. | 06-04-2015 |