Patent application number | Description | Published |
20140294856 | COMBINATION TREATMENT COMPRISING A HDAC6 INHIBITOR AND AN AKT INHIBITOR - The invention provides compositions comprising a Histone Deacetylase 6 (HDAC6) inhibitor and an AKT inhibitor, pharmaceutical compositions/formulations and kits of parts comprising the same; optionally further comprising one or more anti-cancer agents. The compositions of the invention provide for surprisingly efficacious killing of inter alia, cancer cells. Thus, the invention also provides for the use of the compositions, pharmaceutical compositions and kits of parts in medicine, and further, for use in the prevention or treatment of cancer and/or neuro-degenerative conditions, including Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis (ALS), spinal and bulbar muscular atrophy (SbMA), Rubinstein-Taybi syndrome, Rett syndrome, and Friedreich's ataxia, or autoimmune diseases, including Rheumatoid Arthritis, Myasthenia Gravis, and Multiple Sclerosis. | 10-02-2014 |
Patent application number | Description | Published |
20100063144 | COMPOUNDS AND USES THEREOF - There is provided a compound of formula (I) wherein R | 03-11-2010 |
20110236312 | NUCLEOSIDE ANALOGUES USEFUL AS POSITRON EMISSION TOMOGRAPHY (PET) IMAGING AGENTS - The invention provides compounds that comprise a 4′-thio nucleoside that is a derivative of 4′-thiothymidine or 4′-thio-2′-deoxyuridine comprising a positron or single photon emitting radioisotope or corresponding non-radioactive isotope attached via a triazole link to the N-3 position. Methods for preparing such compounds and uses of the compounds in medicine are also provided. | 09-29-2011 |
20130178653 | NOVEL PRECURSOR OF RADIOLABELLED CHOLINE ANALOG COMPOUNDS - The present invention describes intermediate(s), pre-cursor(s), for the preparation of radialabelled choline analogs to be used as radiotracers for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of diseases. | 07-11-2013 |
20130183239 | ISOTOPIC CARBON CHOLINE ANALOGS - Novel choline-derived radiotracer (s) having an isotopic carbon for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of disease states related to altered choline metabolism (e.g., tumor imaging of prostate, breast, brain, esophageal, ovarian, endometrial, lung and prostate cancer—primary tumor, nodal disease or metastases). | 07-18-2013 |
20130202530 | NOVEL RADIOTRACER - Novel radiotracer(s) for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of disease states related to altered choline metabolism (e.g., tumor imaging of prostate, breast, brain, esophageal, ovarian, endometrial, lung and prostate cancer—primary tumor, nodal disease or metastases). The present invention also describes intermediate(s), pre-cursor(s), pharmaceutical composition(s), methods of making, and methods of use of the novel radiotracer(s). | 08-08-2013 |
20130343990 | RADIOLABELLED OCTREOTATE ANALOGUES AS PET TRACERS - Novel radiotracer(s) for Positron Emission Tomography (PET) imaging are described. Novel radiotracer(s) for Positron Emission Tomography (PET) imaging of neuorendocrine tumors are described. Specifically the present invention describes novel [18F]Fluoroethyltriazol-[Tyr3]Octreotate analogs; in particular those that target somatostatin receptors found on the cell surface of gastroenteropancreatic neuorendocrine tumors. The present invention also describes intermediate(s), precursor(s), pharmaceutical composition(s), methods of making, and methods of use of the novel radiotracer(s). | 12-26-2013 |
20150126708 | RADIOFLUORINATION METHOD - The present invention provides a method of radio fluorination of biological targeting molecules (BTMs) with the radioisotope | 05-07-2015 |
Patent application number | Description | Published |
20140199056 | QUARTZ UPPER AND LOWER DOMES - Embodiments of the invention relate to a dome assembly. The dome assembly includes an upper dome comprising a central window, and an upper peripheral flange engaging the central window at a circumference of the central window, wherein a tangent line on an inside surface of the central window that passes through an intersection of the central window and the upper peripheral flange is at an angle of about 8° to about 16° with respect to a planar upper surface of the peripheral flange, a lower dome comprising a lower peripheral flange and a bottom connecting the lower peripheral flange with a central opening, wherein a tangent line on an outside surface of the bottom that passes through an intersection of the bottom and the lower peripheral flange is at an angle of about 8° to about 16° with respect to a planar bottom surface of the lower peripheral flange. | 07-17-2014 |
20140261185 | EPI BASE RING - Embodiments described herein relate to a base ring assembly for use in a substrate processing chamber. In one embodiment, the base ring assembly comprises a ring body sized to be received within an inner circumference of the substrate processing chamber, the ring body comprising a loading port for passage of the substrate, a gas inlet, and a gas outlet, wherein the gas inlet and the gas outlet are disposed at opposing ends of the ring body, and an upper ring configured to dispose on a top surface of the ring body, and a lower ring configured to dispose on a bottom surface of the ring body, wherein the upper ring, the lower ring, and the ring body, once assembled, are generally concentric or coaxial. | 09-18-2014 |