53rd week of 2020 patent applcation highlights part 40 |
Patent application number | Title | Published |
20200408738 | METHOD FOR IDENTIFYING POSITIVE ALLOSTERIC MODULATORS FOR ODORANT RECEPTORS - The various aspects presented herein relate to the perfumery industry. More particularly, the various aspects presented herein relate to assays and methods for screening and identifying compositions and/or ingredients that intensify a subject's perception of target odorant compounds based on the use of particular olfactory receptors activated by the target odorant compound. | 2020-12-31 |
20200408739 | Carbopyronone Compounds Useful as Diagnostic Adjuvants - Described herein are fluorescent compounds and methods and comprising these compounds. The compounds disclosed herein are carbopyronine reagents that fluoresce in the red portion of the UV/VIS spectrum and provide bright fluorescence intensity, uniform cell staining, and good retention within live cells as well as low toxicity toward cells. | 2020-12-31 |
20200408740 | METHOD FOR SENSITIVITY TESTING OF CANNABINOIDS ON PATIENTDERIVED TUMOR BIOPSIES AND CTCS - The present invention discloses a method useful for selecting a personalized cannabinoid-based therapy for a mammalian subject diagnosed with cancer. The method comprises steps of: in vitro contacting (i) genetically identifiable non-cancerous biological specimens from said mammalian subject; (ii) genetically identifiable cancerous biopsy specimens from said mammalian subject; and (iii) genetically identifiable circulating tumor cells (CTCs) with a plurality of cannabinoid analytes; recording data on the outcome of said in vitro contact; selecting a first cycle personalized cannabinoid therapy for said mammalian subject; monitoring therapeutic response of said mammalian subject to said selected therapy; detecting signals derived from said CTCs at n time points, wherein n is an integer equal or higher than 2, comprising of at least one time point before start of said personalized therapy and at least a second time point at a time during said first cycle; and processing said detected signals with said therapeutic response of said first cycle and selecting a second cycle of clinical personalized therapy for said mammalian subject. The present invention further discloses a system thereof and a method useful for selecting a personalized cannabinoid-based regime for cancer prevention in sub clinical individuals. | 2020-12-31 |
20200408741 | PLASMA MEMBRANE CITRATE TRANSPORTER FOR USE IN THE DIAGNOSIS AND TREATMENT OF CANCER - The present invention is directed to a method for the diagnosis of cancer involving the plasma membrane citrate transporter (pmCiC). The invention is further directed to a modified substrate or modulator of pmCiC, the use of pmCiC as a tumor marker and a method of screening for a modulator of pmCiC activity. | 2020-12-31 |
20200408742 | SYSTEMS AND METHODS FOR DISCRIMINATING EFFECTS ON TARGETS - Systems and methods for determining whether a set of test perturbations discriminates over a null distribution for an on target effect against a first component of an entity are disclosed. The perturbations are perturbations of the first component and the entity comprises a plurality of components. For each perturbation in the set, a corresponding vector comprising a plurality of elements, is obtained. Each element comprises a distribution metric of measurements of a feature across instances of the entity upon exposure to the respective perturbation or (ii) a distribution metric of a respective dimension reduction component computed using the measurement of the plurality of features across instances of the entity upon the perturbation exposure. A composite metric is computed, using the vectors, and compared to a null distribution. When the composite metric is differentiated from the null distribution, the set of perturbations is deemed to discriminate the on target effect against the first component over the null distribution. | 2020-12-31 |
20200408743 | DRUG EVALUATION METHOD - An object of the present invention is to provide a novel evaluation system that is particularly useful in researches on the onset mechanism and pathologic conditions of a central nervous system disease, development of a therapeutic method, or the like. The efficacy of a test substance is evaluated using a movement pattern defined by variations in movement of individual cells constituting a cell population as an index. | 2020-12-31 |
20200408744 | ORGANS-ON-CHIPS AS A PLATFORM FOR EPIGENETICS DISCOVERY - The present invention relates to microfluidic fluidic devices, methods and systems for use in identifying epigenetic signatures in a range of sample types, e.g., cells established on a “chip” (including but not limited to single cell samples, cell populations, C cell layers and whole tissues, such as a biopsy), immune cells, cfDNA, exosomes, and the like. More specifically, in some embodiments, a microfluidic chip containing a sample is contacted with a test compound (e.g. DNA altering test compound, an RNA expression altering test compound, etc.) for use in providing a diagnostic epigenetic signature for that type of sample (or cell type) exposed to that specific test compound. In some embodiments, after contact with a test compound, effluent fluids (e.g. fluids exiting the “chip” that contacted the cells) are derived for testing as a “virtual blood draw.” In some embodiments, epigenetic signatures include (but are not limited to) identifying specific combinations of modifications of chromosomes and specific modifications of DNA. | 2020-12-31 |
20200408745 | METHOD FOR BIOSENSING A BINDING ABILITY AMONG A BIOMOLECULE AND A VIRUS USING VIRAL-LASING DETECTION PROBES - Selective amplification of DNA in PCR exponentially increases the signal in molecular diagnostics for nucleic acids, but analogous techniques exist for signal enhancement in clinical tests for proteins or cells. Instead, the signal from affinity-based measurements of these biomolecules depends linearly on probe concentration. Substituting antibody-based probes tagged for fluorescent quantification with lasing detection probes would create a new platform for biomarker quantification based on optical rather than enzymatic amplification. Here, a viral laser is constructed which bridges synthetic biology and laser physics, and demonstrates viral-lasing probes for biosensing. At the transition to lasing, photon flux from the probes increases by five orders of magnitude and narrows spectral linewidth to below 5.0 nm. Viral-lasing probes display an unprecedented >1,000,000% increase in signal from only a 50% increase in probe concentration, using fluorimeter-compatible optics, and can detect biomolecules at clinically-relevant concentrations. | 2020-12-31 |
20200408746 | Stabilized Peptides for Biomarker Detection - This disclosure describes stabilized peptides and methods for detecting a biomarker on, outside, or within a live cell or tissue, or in a cell or tissue that has been fixed for an immunological assay or histopathologic evaluation. The present disclosure further describes stabilized peptides and methods for diagnosing and/or monitoring the progression of a disease in a subject, or for monitoring the efficacy of a disease treatment in a subject, based on the presence of a biomarker, the amount of a biomarker, and/or the localization of a biomarker in a live or fixed cell or tissue obtained from a subject. | 2020-12-31 |
20200408747 | DIGITAL IMMUNOASSAY - Methods of detecting an analyte in a sample are provided. In one embodiment, the method comprises forming a partition comprising the sample, a binding agent capable of emitting a signal when bound to the analyte, and a marker capable of identifying the partition; allowing the binding agent to bind to the analyte, if present; and detecting the presence of the analyte in the sample by detecting the signal emitted from the binding agent in the partition. | 2020-12-31 |
20200408748 | Antibody Substance Detection - When anti-bodies recognize any foreign substance in the body it creates a copy to replace light variable chains of the Anti-Body; specific to, I say with most certainty, every substance you ingest. The presence of any substance in your body (drugs, proteins, allergens, haptins, ect) creates an humoral response which creates antibodies specific to the substance. A molecule specific to the antibody in question is attached to a surface and the antibody in question binds to that molecule. This novel technique is the purpose behind the patent. | 2020-12-31 |
20200408749 | IN VITRO DIAGNOSIS DEVICE COMPRISING BEADS AND USES THEREOF - The present invention relates to an in-vitro diagnosis device for detecting and/or identifying antigen and/or antibody from a sample of biological fluid, particularly from a sample of blood or sample of blood components. The invention also relates to different uses of this device such as the detection and/or the identification of red blood cells antigens, platelet antigens, viralantigens, bacterial antigens, parasite antigens, the detection and/or the identification of anti-red blood cells antibodies, antiplatelet antibodies, antiviral antibodies, antibacterial antibodies and antiparasitic antibodies. | 2020-12-31 |
20200408750 | SYSTEMS AND METHODS FOR ENHANCED DETECTION AND QUANTIFICATION OF ANALYTES - Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample. | 2020-12-31 |
20200408751 | METHODS, SYSTEMS AND KITS FOR IN-PEN ASSAYS - Methods, systems and kits are described herein for detecting the results of an assay. In particular, the methods, systems and devices of the present disclosure rely on a difference between the diffusion rates of a reporter molecule and an analyte of interest in order to quantify an amount of analyte in a microfluidic device. The analyte may be a secreted product of a biological micro-object. | 2020-12-31 |
20200408752 | FLUIDIC SYSTEM FOR PERFORMING ASSAYS - A fluidic testing system and method for use are presented. The fluidic testing system includes a microfluidic channel, a first chamber and second chamber. The microfluidic channel has only one port for the introduction and/or extraction of fluid through the microfluidic channel. The first chamber is disposed at a terminal end of the microfluidic channel. The second chamber is coupled to the fluidic channel and is aligned such that each opening to the second chamber is configured to be aligned substantially parallel to a gravity vector during operation. | 2020-12-31 |
20200408753 | SPECIMEN DILUENT, METHOD FOR PREPARING SAMPLE, SAMPLE, AND SANDWICH METHOD - An object of the present invention is to provide, in order to quantify a detection target substance contained in a specimen, a specimen diluent capable of reducing an influence of contaminants, that is, noise with respect to a quantitative value of a detection target to obtain favorable signal sensitivity, a method for preparing a sample, a sample, and a sandwich method. A specimen diluent of the present invention is a specimen diluent used in a sandwich method, the specimen diluent containing 10 mM to 500 mM of a compound having a structure represented by formula (I) and 10 mM to 500 mM of a compound having a thiol group. | 2020-12-31 |
20200408754 | METHOD OF DETECTING OR QUANTIFYING DETECTION TARGET IN SPECIMEN, COMPOSITE PARTICLE, AND REAGENT - According to one embodiment, a method of detecting or quantifying a detection target in a specimen includes: irradiating a reaction mixture containing composite particles and the specimen with light to promote binding between the composite particles and the detection target; and performing measurement on the reaction mixture irradiated with the light to detect or quantify the detection target. The composite particles each include a carrier particle including two or more regions having different physical properties on a surface, and an affinity substance carried on the carrier particle and having affinity to the detection target. The light can be absorbed by at least one of the two or more regions. | 2020-12-31 |
20200408755 | FLOW TEST UNIT, KIT, AND USE OF A FLOW TEST UNIT FOR PERFORMING A DETECTION REACTION - A flow test unit ( | 2020-12-31 |
20200408756 | METHODS AND KITS FOR EVALUATING CLINICAL OUTCOMES OF AUTOIMMUNE DISEASE - Methods and kits for evaluating a clinical outcome of an autoimmune disease, specifically disease flare e.g. if the subject stops taking the biologic disease modifying anti-rheumatic drug (DMARD), by comparing biomarkers of CD45RA, TNF-alpha and/or CXCR5 from CD3 | 2020-12-31 |
20200408757 | Methods and Compositions for Modulating TH-GM Cell Function - Disclosed herein is a T-helper cell (“T | 2020-12-31 |
20200408758 | COMPOSITIONS AND METHODS FOR DETECTING MYCOBACTERIUM TUBERCULOSIS - The present invention relates to the field of | 2020-12-31 |
20200408759 | METHOD FOR IDENTIFYING MODULATORS OF G3BP ACTIVITY - A method of identifying a lead or candidate compound that modulates the activity of GTPase-Activating Protein SH3 Domain-Binding Proteins (G3BP) is provided, which includes determining whether a compound modulates the interaction between the N-terminal Nuclear Transport Factor 2-like (NTF2L) domain of G3BP and FGDF peptide of ubiquitin specific protease 10 (USP10) or non-structural protein 3 (nsP3). | 2020-12-31 |
20200408760 | GASTROINTESTINAL CANCER DETERMINATION METHOD - The invention provides gastroenterological cancer determination methods that involve contacting a specimen, an antibody 1 that recognizes an α chain of human haptoglobin, and an antibody 2 that recognizes a β chain of human haptoglobin and does not recognize human haptoglobin in which an S—S bond is cleaved to form a complex 1, or contacting the specimen and two antibodies selected from the antibodies 2 that recognize a β chain of human haptoglobin and do not recognize human haptoglobin in which an S—S bond is cleaved to form a complex 2. A determination is made based on the measurement of complex 1 or 2. Alternatively, the specimen and two antibodies selected from the antibodies 1 that recognize an α chain of human haptoglobin are contacted to form a complex 3, and a determination is made by comparing the measurement results of complex 1 or 2 with complex 3. | 2020-12-31 |
20200408761 | METHODS OF DIAGNOSING AND TREATING BLADDER CANCER - A method of diagnosing high grade bladder cancer is provided. The method comprising detecting in a urine sample of a subject in need thereof expression of CD24, wherein an increase in said expression of CD24 above a predetermined threshold as compared to a control sample is indicative of said high grade bladder cancer. | 2020-12-31 |
20200408762 | SYSTEMS AND METHODS OF DIAGNOSING AND PROGNOSING CANCER - The present invention provides a method for monitoring esophageal adenocarcinoma (EAC) disease progression in a subject, the method comprising: obtaining a biological sample from the subject; measuring with a quantitative analytical method at least one metabolite; determining a metabolomic biosignature of EAC disease progression based on a comparison of quantitative data for the at least one metabolite to corresponding data obtained for at least one reference sample; and identifying active EAC disease progression in the subject if the quantity of the at least one metabolite in the sample from the subject is greater than that found in the at least one reference sample. | 2020-12-31 |
20200408763 | Novel stool-based protein biomarkers for colorectal cancer screening - The invention relates to methods for typing a sample of an individual suffering from a colorectal cancer, or suspected of suffering therefrom. A preferred sample is stool. The invention further relates to methods for determining a level of expression of at least two extracted protein expression molecules in stool, based on the quantified reaction products, and to methods of assigning treatment to an individual that was typed as suffering from colorectal cancer according to the invention. | 2020-12-31 |
20200408764 | COLORECTAL CANCER DIAGNOSIS COMPRISING DETECTION OF lgG4 - The invention belongs to the field of biological medicine, and relates to use of an IgG4 detection reagent, a subclass of immunoglobulin, in preparation of a colorectal cancer diagnosis or prognosis reagent/kit. According to the present invention, IgG4, a subclass of immunoglobulin, is highly expressed in colorectal cancer with great difference and credibility. Use of IgG4 as a colorectal cancer diagnostic biomarker has advantages of being strong in specificity and high in sensitivity, which is beneficial to improving the diagnosis and treatment level of colorectal cancer, and effectively prevents and treats colorectal cancer. | 2020-12-31 |
20200408765 | NOVEL ANTI-CD38 ANTIBODIES FOR THE TREATMENT OF CANCER - Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of same with cytotoxic agents, which specifically bind to CD38, are capable of killing CD38 | 2020-12-31 |
20200408766 | Palmitoyl Protein Biomarkers in Purified Extracellular Vesicles for Early Identification of Clinically Significant Prostate Cancer - The invention provides for methods for isolating large EVs and detecting palmitoyl proteins in the large EVs, as well as methods for detecting clinically significant prostate cancer based on the presence of palmitoyl proteins in the isolated large EVs in a subject in need thereof. The method further comprises administering cancer therapy to the subject. | 2020-12-31 |
20200408767 | COMPOSITIONS, ASSAYS, AND METHODS FOR DIRECT MODULATION OF FATTY ACID METABOLISM - This disclosure relates to the surprising and unexpected finding that the well-known cancer protein, Myeloid Cell Leukemia-1 (MCL-1), binds to and modulates the enzymatic activity of Very Long Chain Acyl CoA Dehydrogenase (VLCAD), thereby regulating fatty acid β-oxidation. This finding is employed in compositions and methods of treating cancer, metabolic diseases, or other conditions characterized by excessive fatty acid β-oxidation by blocking or reducing the energy production of cells (e.g., cancer) through inhibiting the MCL-1/VLCAD interaction and/or directly inhibiting VLCAD enzymatic activity. In addition, the disclosure features methods for identifying such agents that inhibit the interaction between MCL-1 and VLCAD or that inhibit VLCAD enzymatic activity. | 2020-12-31 |
20200408768 | SEROLOGIC TEST FOR THERAPY CONTROL OF HPV16 POSITIVE CARCINOMA - A method for therapy control of HPV16 positive carcinoma, an antibody for use in the corresponding diagnostic method as well as a test for performing the method. In particular, a serologic method for monitoring the development of the amount of antibodies in samples, which were taken from a patient before and after the treatment of a HPV16 positive carcinoma over a predetermined period of time. In addition, an immunologic test in the form of a kit, with which the method can be performed. | 2020-12-31 |
20200408769 | TUMOR MARKER, AND METHOD FOR COLLECTING AND DETECTING TUMOR CELL IN DISTINCTION FROM CONTAMINANT CELL - A method of collecting and detecting a tumor cell contained in a sample in distinction from a contaminant cell is provided. The tumor cell contained in the sample are collected and detected in distinction from the contaminant cell by detecting any of the following polypeptides or a gene encoding the polypeptide present in the sample: (i) a polypeptide containing at least the amino acid sequence of any of six sequences such as TM4SF1 (GenBank No. NP_055035.1) and TNFRSF12A (GenBank No. NP_057723.1); (ii) a polypeptide containing at least an amino acid sequence having a homology of not less than 70% to the amino acid sequence described above; and (iii) a polypeptide containing at least a splicing variant of the amino acid sequence (the amino acid sequence of (i) or (ii) described above). | 2020-12-31 |
20200408770 | METHOD FOR ISOLATING CELL NUCLEI HAVING ENHANCED ANTIGENICITY FROM FIXED CELLS OR FFPE TISSUE SECTION, AND ANTIGEN ACTIVATOR AND KIT THEREFOR - Provided are a pretreatment method for detecting the number of cells containing Ki-67 protein-positive nuclei using Ki-67 antibody; a method for the detection; a kit to be used in the detection method; and determination of a therapy regimen using the aforesaid method. Attempts were made to activate Ki-67 antigen with the use of an enzyme having been considered as inappropriate for the activation thereof. By pretreating a sample with an enzyme not recognizing the epitope of MIB-1 (a rare cutter enzyme), the antigen activation of Ki-67 antigen was enhanced, while enhancing the antigenicity of other antigens including a cytokeratin too. As a result, a method for more objectively and more universally quantifying Ki-67-positive cells at higher reproducibility, said method comprising isolating cell nuclei from an FFPE section while enhancing the antigenicity and performing a reaction between Ki-67 protein, i.e., the target, existing in the cell nuclei with a fluorescently labeled antibody, has been completed. | 2020-12-31 |
20200408771 | CD153 AND/OR CD30 IN INFECTION - In an embodiment, the invention provides a method of diagnosing infection in a subject. In an embodiment, the invention provides a method of determining the latency of infection in a subject. In an embodiment, the invention provides a method of determining the effectiveness of a vaccine against infection in a subject. In an embodiment, the invention provides a method of determining the severity of infection in a subject. In an embodiment, the invention provides a method of preventing or treating infection in a subject. | 2020-12-31 |
20200408772 | REAGENT KIT, MEASUREMENT KIT, AND MEASUREMENT METHOD - An object of the present invention is to provide a reagent kit, a measurement kit, and a measurement method for immunologically measuring serum amyloid A with high accuracy and high sensitivity without using an alcohol designated as a hazardous material on the fire protection law. According to the present invention, provided is a reagent kit for measuring serum amyloid A, including first particles having a label and modified with a first binding substance having a property of specifically binding to serum amyloid A, and at least one nonionic surfactant having a molecular weight of 1000 or less. | 2020-12-31 |
20200408773 | REAGENT KIT, MEASUREMENT KIT, AND MEASUREMENT METHOD - An object of the present invention is to provide a reagent kit, a measurement kit, and a measurement method for measuring serum amyloid A, which enable measurement having a high correlation of an increase in signal with respect to the concentration of serum amyloid A. According to the present invention, provided is a reagent kit for measuring serum amyloid A, including first particles having a label and modified with a first binding substance having a property of specifically binding to serum amyloid A, and at least one nonionic surfactant having an HLB value of 17 to 20, which is defined by (inorganicity value/organicity value)×10 and a molecular weight of 1000 or less. | 2020-12-31 |
20200408774 | Bioinformatics Platform for High-Throughput Indentification and Quantification of O-Glycopeptide - The present invention relates to a bioinformation processing analysis method for the identification and quantification of O-linked glycopeptide using high resolution mass spectrum. Particularly, according to the bioinformation processing analysis method of the present invention, the quantitative changes of O-linked glycopeptide containing non-informed sugar chains included in various samples can be efficiently and accurately analyzed; the prediction or diagnosis of disease including cancer can be made easy by using a high resolution mass spectrometer; or the investigation of O-linked glycopeptide structure of a therapeutic glycoprotein can be efficiently achieved. | 2020-12-31 |
20200408775 | APPARATUS AND METHOD FOR MULTIPLEXED PROTEIN QUANTIFICATION - The present disclosure provides a method and apparatus for improvements of sample throughput in proteome analysis by mass spectrometry, by combining multiple non-overlapping isoelectric focusing separations. The method for performing an analysis of a plurality of protein samples, comprises: (a) Adding a proteolytic enzyme of a given specificity to a first protein sample to digest proteins to peptides; (b) Separating the peptides obtained in step (a) by isoelectric focusing; (c) Collecting those peptides which have their isoelectric point value within a first isoelectric point range; (d) Adding a proteolytic enzyme of a given specificity to a second protein sample to digest proteins to peptides; (e) Separating the peptides obtained in step (d) by isoelectric focusing; (f) Collecting those peptides which have their isoelectric point value within a second isoelectric point range, where said second isoelectric point range is different and non-overlapping compared to said first isoelectric point range; (g) Combining the peptides collected in steps (c) and (f) into a single sample and subjecting said sample to mass spectrometry analysis; (h) Deconvoluting signals/data obtained from the mass spectrometry analysis by calculating the isoelectric point of each peptide, and assigning a peptide to the first protein sample if its isoelectric point value matches the isoelectric point range selected in step (c) or to the second protein sample if its isoelectric point value matches the isoelectric point range selected in step (f); and (i) Obtaining quantitative information for proteins of each sample according to magnitude of the signal obtained from each peptide. | 2020-12-31 |
20200408776 | METHOD OF ASSESSING RISK OF PML - The invention relates to methods of assessing a patient's risk of developing Progressive multifocal leukoencephalopathy (PML). | 2020-12-31 |
20200408777 | QUANTITATIVE BIOMARKERS OF EHV-1 SUSCEPTIBILITY AND PROTECTION - The present disclosure is directed to novel biomarkers useful for staging EHV-1 infections and immunity status of horses. This disclosure is further directed to methods of determining EHV-1 infection stage and immunity status of horses using the novel biomarkers. | 2020-12-31 |
20200408778 | FC-GAMMA RECEPTOR MUTANTS - The present disclosure relates to a polypeptide including an Fc-gamma receptor mutant. The Fc-gamma receptor mutant of the present disclosure is optimized by substituting a part of an amino acid sequence of an Fc-gamma receptor with a different amino acid sequence, so as to provide an excellent selective binding ability to immunoglobulins. Therefore, it can be usefully used for increasing in vivo half-life of drugs, detecting and purifying immunoglobulins, inhibiting organ transplant rejections, or preventing or treating autoimmune diseases. | 2020-12-31 |
20200408779 | DOC2B AS A BIOMARKER FOR TYPE 1 DIABETES - Disclosed is the use of DOC2B as an early stage biomarker for diagnosing type 1 diabetes (T1D) or pre-T1D or for assessing the risk of T1D or pre-T1D. Also disclosed are methods of in vivo diagnosing T1D or pre-T1D or assessing the risk of T1D or pre-T1D by detecting a reduced level of DOC2B expression in a biological sample including blood, plasm, serum, platelets, and pancreatic islets. | 2020-12-31 |
20200408780 | DIAGNOSTIC FOR SJORGREN'S SYNDROME BASED ON A BIOMARKER - A method, assay, peptide and antibody that forms an antibody-antigen conjugate with the peptide comprising the amino acid sequence:
| 2020-12-31 |
20200408781 | ASSAYS TO DETECT NEURODEGENERATION - Methods of measuring the amount of singly- or multiply-phosphorylated p217+ tau protein in a sample are provided. Methods of detecting or diagnosing tauopathies, methods of determining the effectiveness of a treatment of a tauopathy, and methods of determining whether a subject is suitable for anti-p217+ tau antibody therapy are also provided. Also described are antibodies for use in the methods and kits comprising the antibodies. | 2020-12-31 |
20200408782 | DETECTION OF PATHOLOGICAL PROTEIN AGGREGATION - The present invention provides novel methods of identifying, monitoring or determining the risk of developing a protein misfolding neurodegenerative disorder in a subject, particularly an alpha synucleinopathy (including Parkinson's disease and dementia with Lewy bodies) using extracellular vesicle samples. Corresponding methods for selecting a treatment and assaying for the presence of a pathological prion-like protein (or one or more ceramide species) in an extracellular vesicle sample are also provided. | 2020-12-31 |
20200408783 | DETECTION OF ALZHEIMER'S DISEASE (AD), FRONTOTEMPORAL LOBAR DEGENERATION (FTLD), AMYOTROPHIC LATERAL SCHLEROSIS (ALS), PARKINSON'S DISEASE (PD), AND DEMENTIA WITH LEWY BODIES (DLB) INDICATED BY PHOSPHORYLATION OF MARCKS - Provided is a method for detecting a neurodegenerative disease selected from the group consisting of human Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD), and amyotrophic lateral sclerosis (ALS) with high sensitivity and high specificity. A method for detecting a neurodegenerative disease selected from the group consisting of human Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD), and amyotrophic lateral sclerosis (ALS), comprising the steps of: (i) measuring a MARCKS protein phosphorylated at position 46 and a non-phosphorylated MARCKS protein in a test specimen collected from a subject; (ii) calculating a DO value expressed by the following formula from the measured values obtained in (i): | 2020-12-31 |
20200408784 | SYSTEM FOR MEASURING TOTAL HEMOGLOBIN IN BLOOD AND METHOD OF DOING THE SAME - This invention relates to the measurement of hemoglobin in the blood. Previously, chemical interference from medications, other blood components, and incomplete reagent rehydration can impact the accuracy and prolong the reaction time required to determine total hemoglobin in blood. Embodiments of the present invention use a disposable body is housed within the capillary channel and adapted to receive a flow of blood from the entrance such that air in the disposable body is pushed out through a vent. A measurement system is configured to measure a property of the flow of blood. That property can be correlated to total hemoglobin count. | 2020-12-31 |
20200408785 | PHOTONIC PATHOGEN DETECTION - Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined. | 2020-12-31 |
20200408786 | METHOD FOR RAPID AND QUANTITATIVE DETERMINATION OF SILDENAFIL IN COCKTAIL - A method for rapid and quantitative determination of sildenafil in cocktail includes the exemplary steps of: Step 1, assigning a Raman spectrum of sildenafil; Step 2, weighing and dissolving a sildenafil standard in methanol to obtain a 1,000 mg/L sildenafil standard solution, and mixing cocktails with the sildenafil standard solution, to prepare test solutions; Step 3, mixing 100 μL each of test solutions with 500 μL of surface enhancer OTR 202 to acquire Raman spectra; and Step 4, establishing a linear regression model, with a formula of y=4035.1 x+503.26, where y is the content of sildenafil in cocktail, in mg/L, and x is intensity of Raman characteristic peaks at 1584 cm | 2020-12-31 |
20200408787 | STABILIZED QUALITY CONTROL MATERIALS FOR RED BLOOD CELLS FOR DIAGNOSTIC TESTS - A quality control material, its method of preparation and it use as a control composition for diagnostic tests are described. The quality control material comprises: non-fixed viable red blood cells; and a support medium comprising: abutter; a polyol; adenine and fructose. | 2020-12-31 |
20200408788 | MEASURING APPARATUS FOR A LABORATORY APPLIANCE FOR MEASURING AN ARTICLE, ARTICLE FOR SAID MEASURING APPARATUS AND MEASURING METHOD - The invention relates to a measuring apparatus for detecting the relative position of an end portion of a pipetting container by an interaction between a measurement support section of the pipetting container and the measuring apparatus. The invention relates to an automatic laboratory, which comprises this measuring apparatus and to a corresponding measuring method. | 2020-12-31 |
20200408789 | INFORMATION PROCESSING APPARATUS, METHOD FOR CONTROLLING INFORMATION PROCESSING APPARATUS, AND PROGRAM - An apparatus includes an acquisition unit configured to acquire quantitative information on a test substance, the quantitative information being estimated by inputting, to a learning model, two or more pieces of spectral information selected from a plurality of pieces of spectral information on a sample containing the test substance and a foreign substance. | 2020-12-31 |
20200408790 | METHOD OF HANDLING LABORATORY SAMPLE CONTAINERS BY A LABORATORY SAMPLE CONTAINER HANDLING SYSTEM, A LABORATORY SAMPLE CONTAINER HANDLING SYSTEM, AND A LABORATORY AUTOMATION SYSTEM - A method of handling laboratory sample containers by a laboratory sample container handling system is presented. The method comprises providing a laboratory sample container comprising an assigned ID information to the laboratory sample container handling system, reading the assigned ID information, checking, if the read ID information is unique or not unique within the laboratory sample container handling system, and if the read ID information ( | 2020-12-31 |
20200408791 | Method of information transmission, a liquid handling device, and a system - According to an example aspect of the present invention, there is provided a method of information transmission in a system comprising at least one liquid handling device and at least one external device, the method comprising: in one or more of said at least one liquid handling device, producing a machine-readable code that contains information that is derived from a status or properties of the respective liquid handling device or information that has been stored in the respective liquid handling device; in said one or more of said at least one liquid handling device, displaying the respective code on a display that is integrated to a structure of the respective liquid handling device; reading the displayed code or one or more of the displayed codes by an external device. | 2020-12-31 |
20200408792 | DISPLAY DEVICE, SAMPLE MEASUREMENT SYSTEM, DISPLAY METHOD AND PROGRAM - The present invention facilitates comprehension of the actual positions of constituent units of a sample measurement system regardless of a direction in which a user faces. The present invention provides a display device ( | 2020-12-31 |
20200408793 | TESTING SYSTEM, STORAGE DEVICE, AND RACK STORAGE METHOD - The invention allows a rack storage mode to be set in accordance with the situation in a facility. A testing system | 2020-12-31 |
20200408794 | AUTOMATED STORAGE MODULES FOR DIAGNOSTIC ANALYZER LIQUIDS AND RELATED SYSTEMS AND METHODS - Example automated storage modules for analyzer liquids are described herein. An example apparatus includes a refrigerated storage module having a plurality of shelves (to store a plurality of carriers) and a loading bay having an array of slots to receive one or more of the carriers. The loading bay is accessible by a user for manual loading or unloading of the carriers. The example apparatus includes a first carrier transporter coupled to the storage module to transfer the carriers between the shelves and a first transfer location and a second carrier transporter movable along a track connecting the storage module to an automated diagnostic analyzer. The second carrier transporter is to transfer a first carrier between the first transfer location and a slot in the loading bay and a second carrier between the first transfer location and a second transfer location accessible by the automated diagnostic analyzer. | 2020-12-31 |
20200408795 | INERTIAL MEASUREMENT UNIT AND MOVABLE DEVICE USING THE SAME - An inertial measurement unit includes a sensor and a heat preservation system. The heat preservation system includes a heat preservation body and a heat source. The sensor is positioned on the heat preservation body. The heat source is configured to generate heat. The heat preservation body is configured to transfer the heat from the heat source to the sensor to maintain a preset temperature in a space surrounding the sensor. | 2020-12-31 |
20200408796 | FERRITE CORE COIL DEVICE, SENSOR DEVICE FOR DETERMINING ROTATIONAL SPEED OF A ROTATABLE OBJECT WITH SUCH A FERRITE CORE COIL DEVICE AND TURBOCHARGER WITH SUCH A SENSOR DEVICE - A ferrite core coil device as a sensing element for a sensor device determining a rotational speed of a metallic rotatable object includes a coil having a first sector and a second sector and a ferrite core holding the coil. The ferrite core has a shape of a disk lacking a disk sector and defined by a contour of the disk and a chord of the disk. The chord forms a bending edge of the ferrite core. The first sector of the coil is not arranged on a bed of the ferrite core and the second sector of the coil is arranged on the bed. The first sector is bent around the bending edge at a bending angle with respect to the second sector. | 2020-12-31 |
20200408797 | METHOD FOR DETERMINING A DIRECTION OF A SPIN AXIS OF A ROTATING APPARATUS - A method for determining a direction of a spin axis of a rotating apparatus which includes an XYZ-magnetic field sensor. The method includes determining a global direction of a magnetic field; rotating the rotating apparatus around the spin axis, measuring at least one magnetic field value as a function of time with the XYZ-magnetic field sensor when the rotating apparatus is rotating about the spin axis, computing a magnetic field component of the magnetic field in a direction of a local body co-ordinate of the spin axis of the rotating apparatus from the measured at least one magnetic field value and determining a direction of the spin axis using the computed magnetic field component of the magnetic field and the determined global direction of the magnetic field. | 2020-12-31 |
20200408798 | SENSING DEVICE AND SENSING SYSTEM FOR HUMAN-POWERED DEVICES USING THE SAME - A sensing device has a strain gauge device, an idler, and a connecting rod assembly. The sensing device receives a mechanical force to generate a deformation accordingly, and generates a sensing signal according to the deformation. The idler is a ring body which has a ring contracting portion contacting a transmission belt, so as to receive the mechanical force which the transmission belt applies on the idler. A first end of the connecting rod assembly is connected to the strain gauge device via a rod slot which is located on a side of the strain gauge device, and a second end of the connecting rod assembly is pivotally connected to the idler via a pivot connecting portion of the idler, such that the mechanical force which the idler suffers can be transmitted to the strain gauge device. | 2020-12-31 |
20200408799 | Piezoelectric Accelerometer with Wake Function - A sensor device that senses proper acceleration. The sensor device includes a substrate, a spacer layer supported over a first surface of the substrate, at least a first tapered cantilever beam element having a base and a tip, the base attached to the spacer layer, and which is supported over and spaced from the substrate by the spacer layer. The at least first tapered cantilever beam element tapers in width from the base portion to the tip portion. The at least first cantilever beam element further including at least a first layer comprised of a piezoelectric material, a pair of electrically conductive layers disposed on opposing surfaces of the first layer, and a mass supported at the tip portion of the at least first tapered cantilever beam element. | 2020-12-31 |
20200408800 | Surface Acoustic Wave (SAW)-based Inertial Sensor, Methods, and Applications - A SAW-based inertial sensor incorporates a curved SAW drive resonator and graphene electrodes to increase the Coriolis force on a pillar array and generate secondary SAW waves that create a strain-induced hyperfine frequency transition in an enclosed alkali atom vapor, in conjunction with an integrated FP resonator to measure very small inertial signals corresponding to 10 μg and 0.01°/hr, representing a dynamic range of 10 orders of magnitude. | 2020-12-31 |
20200408801 | MULTIPLE ANCHOR HIGH FREQUENCY ACCELEROMETER - Single-axis teeter-totter accelerometers having a plurality of anchors are disclosed. The plurality of anchors may be arranged about a rotation axis of the teeter-totter proof mass. Each of the plurality of anchors may be coupled to the proof mass by two torsional springs each extending along the rotation axis. The plurality of anchors allows an increased number of torsional springs to be coupled to the proof mass and thus greater torsional stiffness for the proof mass may be achieved. Due to the higher torsional stiffness, the disclosed single-axis teeter-totter accelerometers may be deployed in high-frequency environments where such increased torsional stiffness is required, for example, around 20 kHz and above. | 2020-12-31 |
20200408802 | Inertial Sensor, Electronic Instrument, And Vehicle - An inertial sensor includes a substrate, a movable element that swings around a swing axis; and a protrusion that overlaps with the movable element in the plan view and protrudes from the substrate toward the movable element. The protrusion includes a first protrusion and a second protrusion so located as to be farther from the swing axis than the first protrusion, and when the movable element swings relative to the substrate around the swing axis, the first protrusion and the second protrusion come into contact with the movable element at the same time or the first protrusion comes into contact with the movable element and then the second protrusion comes into contact with the movable element. | 2020-12-31 |
20200408803 | CAPACITIVE MICROMECHANICAL ACCELEROMETER - The present invention relates to capacitive micromechanical accelerometers, and in particular to acceleration sensors with movable rotors which may rotate out of a substrate plane when the accelerometer undergoes movement with an acceleration component perpendicular to the substrate plane. The capacitive micromechanical accelerometer includes additional damping springs to reduce unwanted movement of the rotor in the substrate plane, thereby reducing the parasitic capacitance that results from motion of the rotor in the substrate plane. The damping springs are vertically recessed with respect to other components of the accelerometer in order to minimise the effect of the damping springs on movement of the rotor out of the substrate plane. | 2020-12-31 |
20200408804 | INERTIAL SENSOR, ELECTRONIC INSTRUMENT, AND VEHICLE - An inertial sensor includes a movable element including a first movable section and a second movable section, a first detection electrode, and a first dummy electrode. The first movable section has a first section, a second section that is farther from the swing axis than the first section, and a third section disposed between the first section and second section. A separation distance between the third section and the first dummy electrode is greater than a separation distance between the first section and the first detection electrode. | 2020-12-31 |
20200408805 | MEMS ACCELEROMETER SELF-TEST USING AN ACTIVE MOBILE MASS DEFLECTION TECHNIQUE - A microelectromechanical system (MEMS) accelerometer sensor has a mobile mass and a sensing capacitor. To self-test the sensor, a test signal is applied to the sensing capacitor during a reset phase of a sensing circuit coupled to the sensing capacitor. The test signal is configured to cause an electrostatic force which produces a physical displacement of the mobile mass corresponding to a desired acceleration value. Then, during a read phase of the sensing circuit, a variation in capacitance of sensing capacitor due to the physical displacement of the mobile mass is sensed. This sensed variation in capacitance is converted to a sensed acceleration value. A comparison of the sensed acceleration value to the desired acceleration value provides an indication of an error in operation of the MEMS accelerometer sensor if the sensed acceleration value and desired acceleration value are not substantially equal. | 2020-12-31 |
20200408806 | METHOD AND APPARATUS FOR CORRECTING RESPONSIVITY VARIATION IN PHOTOTHERMAL IMAGING - The disclosure is directed to a method and apparatus for correcting responsivity variation in photothermal imaging. The method includes sending, during a first time period, light-driving signal to a light source so that the light source is configured to output a series of light pulses onto a sample, wherein the sample is under photothermal-induced expansion according to the series of light pulses. The method includes obtaining, during the first time period, first deflection signal from a cantilever. The method includes sending, during a second time period, actuator-driving signal to an electromechanical actuator so that the electromechanical actuator is configured to move according to the actuator-driving signal, wherein the electromechanical actuator is coupled with the sample. The method includes obtaining, during the second time period, second deflection signal from the cantilever and obtaining a photothermal image of the sample based on the first deflection signal and the second deflection signal. | 2020-12-31 |
20200408807 | INFORMATION PROVIDING APPARATUS, INFORMATION PROVIDING METHOD, AND SYSTEM - The present invention provides an information providing apparatus including a determining unit configured to determine an added value to be provided to a user of a portable electric power supply device including a storage battery that stores electric power to be supplied to electrical equipment detachably connected, wherein in a case where a kind of the electrical equipment is a specified kind of electrical equipment, the determining unit determines the added value to be provided to the user in such a manner that the added value to be provided to the user is higher than an added value in a case where the kind of the electrical equipment is not the specified kind of electrical equipment. | 2020-12-31 |
20200408808 | INFORMATION PROVIDING APPARATUS, INFORMATION PROVIDING METHOD, AND SYSTEM - The present invention provides an information providing apparatus including a providing unit configured to determine whether electric power stored in a storage battery, included in a portable electric power supply device, that stores electric power to be supplied to electrical equipment detachably connected, can be sold or whether to store electric power in the storage battery, and provide a result of the determination to a user of the electric power supply device, wherein in a case where the providing unit determines that stored electric power can be sold, purchase processing is performed on the stored electric power in accordance with a kind of the electrical equipment inferred, and in a case where the providing unit determines that electric power is to be stored in the storage battery, electric power storing processing is performed on the storage battery in accordance with the kind of the electrical equipment inferred. | 2020-12-31 |
20200408809 | CURRENT SENSOR - A current sensor includes an electrical-conduction member, a magnetoelectric converter, and a shield. The shield includes a first shield and a second shield each having a plate shape. The first shield and the second shield being arranged such that surfaces are opposed to and spaced away from each other. A part of the electrical-conduction member and the magnetoelectric converter are located between the surface of the first shield and the surface of the second shield. The part of the electrical-conduction member extends in an extension direction that is along the surface of the first shield. At least one of the first shield and the second shield has an anisotropy in magnetic permeability in which the magnetic permeability in a lateral direction that is along the surface of the first shield and perpendicular to the extension direction is higher than the magnetic permeability in the extension direction. | 2020-12-31 |
20200408810 | CURRENT SENSOR AND METHOD - A current sensor is for determining the level of the current of a conductor of a low-voltage circuit. In an embodiment, it includes a current transformer including a magnetic core. The magnetic core is an annular core having a core inner diameter, a middle diameter and a core outer diameter. The annular core is wound with a secondary winding, including an inner opening with an inner diameter and an outer circumference with an outer diameter. The secondary winding supplies the circuit with electrical energy. The wound annular core is configured such that the difference between the middle diameter as the minuend and the inner diameter as the subtrahend is 0.5 to 0.6 times smaller than the difference between the outer diameter as the minuend and the inner diameter as the subtrahend, to achieve an optimum for supplying energy and determining the level of the current in connection with the circuit. | 2020-12-31 |
20200408811 | SYSTEMS AND METHODS FOR IMPROVED ROOT MEAN SQUARE (RMS) MEASUREMENT - Systems and methods are provided for improving the operation of a computer or other electronic device that utilizes root-mean-square (RMS) measurements, e.g., RMS current measurements, by reducing error in the RMS measurement. A series of measurement samples are received at a processor, which executes a noise-decorrelated RMS algorithm including: calculating a current-squared value for each measurement sample by multiplying the measurement sample by a prior measurement sample in the series (rather by simply squaring each measurement sample as in conventional techniques), summing the current-squared values, and calculating an RMS value based on the summed values. The processor may also execute a frequency-dependent magnitude correction filter to correct for frequency-dependent attenuation associated with the noise-decorrelated RMS algorithm. The calculated RMS value has a reduced error, particularly for lower-end current measurements, which may improve the operation of the computer or electronic device that utilizes the RMS value. | 2020-12-31 |
20200408812 | Method and Device for Detecting the Absence of Voltage - An installed device electrically connected to a power source. The installed device has circuitry capable of detecting voltage, performing self-diagnostics, and testing for connectivity to the power source. In one embodiment, the device can also check to see if the voltage is at a de-energized level, recheck for continuity and repeat the self-diagnostics. In another embodiment, the installed device can be electrically connected to the line and load side of a disconnect and have circuitry configured to check the status of the disconnect. In another embodiment, the device can be configured to communicate with a portable reader in order to transfer information to the portable reader. In yet another embodiment, the device can be configured to interact with a controller that controls access to the panel in which the device is installed. | 2020-12-31 |
20200408813 | Method for Monitoring Electrical Energy in Traction Power Networks - The present invention provides a method for monitoring electrical power in high-speed rail traction power supply networks/systems, comprising: collecting voltage and current analog signals from a traction power supply system, and converting the voltage and current analog signals into voltage and current digital signals; obtaining, by a processing unit, digital signals and transfer commands; compressing, by the processing unit, the digital signals according to the transfer commands to digital signal frames; and constructing a data link between the processing unit and a storage unit and transmitting the compressed digital signal frame to the storage unit. The processing unit may use run-length coding algorithm to compress the digital signal to be stored to obtain several compressed digital signal frames. Under different conditions of data link, transmission of compressed digital signal frames is adjustable to improve the reliability of digital signal transmission | 2020-12-31 |
20200408814 | VOLTAGE DETECTING CIRCUIT FOR VOLTAGE MEASUREMENT APPARATUS FOR USE IN ASSEMBLED BATTERY SYSTEM - A voltage detection circuit measures a plurality of cell voltages of an assembled battery configured by connecting a plurality of cells in series. The voltage detection circuit includes a plurality of input terminals connected to respective electrodes of the plurality of cells through a plurality of voltage detection lines; a multiplexer that periodically selects and outputs voltages of a plurality of cells in a group, a plurality of series cells configured as the group; an analog-to-digital (AD) converter that AD-converts an output voltage from the multiplexer and outputs digital data of the output voltage; and a control circuit that controls a timing for the selection by the multiplexer and a timing for the AD conversion. The control circuit switches over a time interval for which the multiplexer selects each of the cells to change a period of the AD conversion. | 2020-12-31 |
20200408815 | ENHANCED BACKWARD/FORWARD SWEEP BASED LOAD FLOW APPROACH FOR EXTENDED RADIAL DISTRIBUTION SYSTEM - A method of enhanced backward/forward sweep based power flow analysis is described. The method can include performing a backward sweep to determine first branch currents of a radial distribution network based on nodal voltages determined at a last iteration. The radial distribution network can include nodes and branches that are sequentially numbered and belong to different layers. A forward sweep is determined to determine first nodal voltages of the radial distribution network based on the first branch currents. Second branch currents of the radial distribution network are determined based on the first nodal voltages. The second branch current of the respective node is a sum of a nodal injection current of the respective node that is updated based on the first nodal voltage of the respective node, and if available, the first branch currents of branches emanating from the respective node. | 2020-12-31 |
20200408816 | METHOD FOR EVALUATING THE STATE AND THE QUALITY OF LOW-VOLTAGE NETWORKS - The invention relates to a method for evaluating the state and the quality of low-voltage networks, in the branched system of which there is a plurality of connected loads, by determining network measurement data by means of power quality measuring and testing devices and transferring the network measurement data, by means of a standard interface, to a control system or in retrievable form to a server. According to the invention, the overvoltage protection devices, which are or can be used in the low-voltage system and have a self-diagnosis unit and an existing wireless or wired standard interface for data transfer, are able to determine network measurement data by means of integrated or adapted power quality measuring and testing devices. | 2020-12-31 |
20200408817 | ZIG ZAG BASED LOAD FLOW METHOD AND SYSTEM FOR EXTENDED RADIAL DISTRIBUTION SYSTEMS - A power distribution system configured as a radial network includes buses having respective voltages, and distribution lines having respective currents. The radial network interconnects the buses with the distribution lines in a tree-like manner. A bus has a link to at least two distribution lines. The bus voltages and distribution line currents are determined by a processing circuitry configured to receive a Branch Matrix (BM) iteratively determine currents for the distribution lines and voltages for each of the buses until a difference is below a predetermined tolerance, and output final bus voltages and final distribution line currents. The circuitry iteratively determines the currents by determining a current matrix (CM) using the BM, and by determining the currents for the plurality of distribution lines in a zig zag manner over the matrix elements in the CM. The system finds a solution using fewer iterations than the backward forward sweep method. | 2020-12-31 |
20200408818 | LOAD ESTIMATING DEVICE AND POWER GENERATOR - A load estimating device measures a voltage and a current supplied to a load connected with a generator, calculates a feature amount of the load, senses a remaining amount of fuel, outputs a time during which the load is continuously operable. The device estimates what the load connected with the generator is, based on the calculated feature amount and the feature amounts stored in a storage, and determines the time during which the estimated load is continuously operable, based on a power consumption of the estimated load, and the remaining amount of fuel. The device has a load registration mode for causing the storage to store therein a feature amount of a new load that is not stored in a storage. | 2020-12-31 |
20200408819 | ELECTRONIC DEVICE, CORRESPONDING APPARATUS, METHOD AND COMPUTER PROGRAM PRODUCT - An oscillatory electric signal having an oscillation frequency is processed by time-sampling to generate a sampled oscillatory electric signal. A nonlinear circuit driven by the sampled oscillatory electric signal outputs a hysteretic response signal as a function of the sampled oscillatory electric signal. The hysteretic response signal has a frequency in a first frequency range as a result of an increase in the oscillation frequency of the oscillatory electric signal, and a frequency in a second frequency range as a result of a decrease in the oscillation frequency of the oscillatory electric signal. A detection circuit processes the hysteretic response signal to compute an envelope signal of the hysteretic response signal, perform a comparison of the envelope signal with a threshold, and produce a signal indicative of an increase or a decrease in the oscillation frequency of the oscillatory electric signal as a result of the outcome of the comparison. | 2020-12-31 |
20200408820 | INTERLEAVED ACQUISITION SYSTEM, SINGLE-HOUSE DEVICE AS WELL AS METHOD OF ACQUIRING A HIGH BANDWIDTH INPUT SIGNAL - An interleaved acquisition system for acquiring a high bandwidth input signal, comprising a first acquisition and quantizer unit, a second acquisition and quantizer unit as well as a trigger unit. The first and second acquisition and quantizer units are configured to receive a respective interleaved digitized input signal, to acquire the respective interleaved digitized input signal, to quantize the respective interleaved digitized input signal, and to output a respective quantized interleaved digitized input signal. The trigger unit is configured to receive the respective quantized interleaved digitized input signals from the first and second acquisition and quantizer units. The trigger unit is further configured to de-interleave the respective quantized interleaved digitized input signals. The trigger unit is configured to generate a de-interleaved quantized digitized input signal. The trigger unit is also configured to detect an event in the de-interleaved quantized digitized input signal. Further, a method of acquiring a high bandwidth input signal is described. | 2020-12-31 |
20200408821 | Complex Impedance Battery Monitor - A complex impedance battery monitor has one or more primary switches, a load resistor in series with the primary switches, a current sensor in series with the primary switches, two or more lead wires connected to two or more busbars in a string of batteries, and a digital signal processor. The primary switches are connected to two or more terminals of the batteries in the string of batteries. The primary switches are turned on and off to produce a ripple current in the string of batteries. The digital signal processor determines at least a portion of the complex impedance of at least one of the batteries by analyzing the voltage and current waveform of the ripple current. The primary switches may be turned on and off with a pulse width modulated wave. | 2020-12-31 |
20200408822 | CAPACITIVE VOLTAGE DIVIDER FOR MONITORING MULTIPLE MEMORY COMPONENTS - A memory sub-system includes a plurality of memory components where at least two of the memory components are configured to operate at different supply voltages. A capacitive voltage divider (CVD) configured to, responsive to a status of use of each of the memory components, select between a plurality of connections of a plurality of capacitors to reduce an input voltage of the memory sub-system. The plurality of connections is configured to provide different voltage magnitudes that correspond to the different supply voltages, and the CVD is further configured to output the different supply voltages to enable the use of each of the memory components. | 2020-12-31 |
20200408823 | PORTABLE ANECHOIC CHAMBER - An anechoic chamber and test system that is adapted for installation in or to a vehicle. The chamber includes an outer structure that is durable enough to withstand the effects of transportation. The anechoic chamber and test system may also include an inner faraday shield, a transmission antenna, and a controller that can introduce GNSS, alternative navigation signals, jamming, or spoofing signals into the anechoic chamber along with vehicle sensor signals. The controller is adapted to monitor a GNSS system's ability to resist the jamming or spoofing signals using, at least in part, the vehicle sensor signals. | 2020-12-31 |
20200408824 | MEASURING A LEAKAGE CHARACTERISTIC OF A SIGNAL PATH - An example method measures a leakage characteristic of a signal path. The example method includes forcing a current onto the signal path; determining a parasitic capacitance of the signal path based on a rate of change of a voltage on the signal path resulting from the current; forcing a voltage onto the signal path for a period of time; and following the period of time, determining the leakage characteristic based on the parasitic capacitance and a rate of change in voltage on the signal path from the forced voltage. | 2020-12-31 |
20200408825 | ELECTRICAL CONTINUITY DETECTION SYSTEM - An electrical continuity detection system may comprise a plurality of identification tags placed on an electrically conductive object, and configured to respond to an injection signal on the electrically conductive object with a response, and a monitoring device coupled to the electrically conductive object and configured to generate the injection signal and an injection signal on the electrically conductive object, receive the response from one or more of the plurality of tags, receive a return signal from the electrically conductive object, determine a characteristic of the electrically conductive object based on the received responses and return signals, and generate a notification based on the characteristic. | 2020-12-31 |
20200408826 | SYSTEMS, APPARATUS, AND METHODS FOR LOCATING A FAULT IN A PLURALITY OF WINDINGS OF A TRANSFORMER - There is provided systems, apparatus, and methods for locating a fault in a plurality of windings of a transformer. In one embodiment, the apparatus may include: a measurement device configured to measure electrical flow parameters of the transformer when the transformer is in an online mode; and a fault location determination unit configured to determine electrical flow parameters of the windings from the measured electrical flow parameters of the transformer, wherein the fault location determination unit is configured to process the determined electrical flow parameters of the windings to determine the location of the fault in the windings. | 2020-12-31 |
20200408827 | METHOD AND DEVICE FOR FAULT SECTION IDENTIFICATION IN MULTI-TERMINAL MIXED LINES - The invention provides a method and device for fault section identification in a multi-terminal mixed line. The method comprises obtaining positive sequence voltage and current phasors from measurements of voltages and currents at each terminal of the mixed line. The method further comprises calculating a voltage phasor for each terminal, wherein the calculation of the voltage phasor for a first terminal is performed using at least the voltage and current phasors obtained for one of a second terminal and a third terminal, and the current phasor obtained for the first terminal. Thereafter, the method comprises determining a section of the mixed line having the fault, based on comparison of the calculated and obtained voltage phasors for each terminal. In addition, the method comprises controlling a switching device with a re-trip signal generated based on the determination of the section with the fault. | 2020-12-31 |
20200408828 | TESTING DEVICE - A testing device for inspecting an electronic device by causing contact terminals to electrically contact the electronic device, includes: a mounting table formed with a light transmission member opposite the side on which a inspection object is placed and having therein a coolant flow path through which a coolant capable of transmitting light flows; a light irradiation mechanism disposed so as to face the surface opposite the inspection object placement side of the mounting table, and having LEDs pointing toward the inspection object; and a controller controlling absorption of heat by the coolant and heating by the lights from the LEDs to control the temperature of the electronic device to be inspected. The controller controls the light output from the LEDs based on the measured temperature of the electronic device to be inspected and controls the absorption of heat by the coolant based on the LED light output. | 2020-12-31 |
20200408829 | METHODS OF DETERMINING OPERATING CONDITIONS OF SILICON CARBIDE POWER MOSFET DEVICES ASSOCIATED WITH AGING, RELATED CIRCUITS AND COMPUTER PROGRAM PRODUCTS - Embodiments according to the invention can provide methods of testing a SiC MOSFET, that can include applying first and second voltage levels across a gate-source junction of a SiC MOSFET and measuring first and second voltage drops across a reverse body diode included in the SiC MOSFET responsive to the first and second voltage levels, respectively, to provide an indication of a degradation of a gate oxide of the SiC MOSFET and an indication of contact resistance of the SiC MOSFET, respectively. | 2020-12-31 |
20200408830 | METHOD FOR ESTIMATING DEGRADATION - Method for estimating degradation of a wire-bonded power semiconductor module ( | 2020-12-31 |
20200408831 | Apparatus and Method for Diagnosing Watchdog Timer - An apparatus and method for diagnosing a watchdog timer is provided. The watchdog timer is used to detect and recover from a malfunction of a battery management system. Before entering a shutdown mode in response to a shutdown command from an external device, the apparatus outputs an invalid trigger signal to the watchdog timer and diagnoses a malfunction of the watchdog timer depending on whether the watchdog timer outputs a reset signal. | 2020-12-31 |
20200408832 | PREDICTIVE VOLTAGE TRANSIENT REDUCTION IN INTEGRATED CIRCUITS - Power control arrangements for integrated circuit devices are discussed herein. In one example, an assembly includes an integrated circuit device comprising one or more processing cores and a power domain configured to distribute a supply voltage to the one or more processing cores. The assembly also includes a charge injection circuit coupled to the power domain of the integrated circuit device, and configured to selectively couple electric charge into the power domain to predictively offset at least portions of voltage transients in the power domain. | 2020-12-31 |
20200408833 | TSV TESTING METHOD AND APPARATUS - An integrated circuit die includes a substrate of semiconductor material having a top surface, a bottom surface, and an opening through the substrate between the top surface and the bottom surface. A through silicon via (TSV) has a conductive body in the opening, has a top contact point coupled to the body at the top surface, and has a bottom contact point coupled to the body at the bottom surface. A scan cell has a serial input, a serial output, control inputs, a voltage reference input, a response input coupled to one of the contact points, and a stimulus output coupled to the other one of the contact points. | 2020-12-31 |
20200408834 | APPARATUS AND METHOD FOR EARLY LIFETIME FAILURE DETECTION SYSTEM - An on-die early lifetime failure detection system with a reliability mechanism isolation circuit provides an early lifetime failure detection. The system measures and monitors reliability at time-0 (t0) and end-of-life. The measurements enable detection of latent reliability or marginality issues during the lifetime of the product. The system includes: a stress controller to adjust voltage for a power supply and voltage for a ground supply in accordance with one or more sensors; and an aging detector circuitry coupled to the stress controller, wherein the aging detector circuitry comprises a ring oscillator having delay stages, wherein each delay stage comprises an aging monitor circuitry, wherein the stress controller to adjust voltage for a power supply and voltage for a ground supply of the delay stage. | 2020-12-31 |
20200408835 | PROBER AND METHOD OF PREHEATING PROBE CARD - There is provided a prober including inspection rooms. Each of the inspection rooms includes: a probe card having probes; a chuck top configured to mount a wafer; and a temperature adjuster configured to adjust a temperature of the chuck top. At least one of the probe card and the chuck top includes a gap adjustment member configured to maintain a constant gap between the probe card and the chuck top. The probe card is preheated by heat of the chuck top whose temperature is adjusted by the temperature adjuster, in a state in which the wafer is not mounted on the chuck top and in a state in which the probe card and the chuck top are connected with each other via the gap adjustment member. | 2020-12-31 |
20200408836 | NON-CONTACT DC VOLTAGE MEASUREMENT DEVICE WITH OSCILLATING SENSOR - Systems and methods for measuring DC voltage of an insulated conductor (e.g., insulated wire) are provided, without requiring a galvanic connection between the conductor and a test electrode or probe. A non-contact DC voltage measurement device may include a conductive sensor that is mechanically oscillated. The device may also include a conductive internal ground guard that is galvanically isolated from the conductive sensor, and a conductive reference shield that is galvanically insulated from the internal ground guard. The device may further include a common mode reference voltage source that generates an alternating current (AC) reference voltage, and a sensor signal measurement subsystem electrically coupled to the conductive sensor. Control circuitry may receive a sensor current signal from the sensor signal measurement subsystem, and determine the DC voltage in the insulated conductor based at least in part on the received sensor current signal. | 2020-12-31 |
20200408837 | MEASUREMENT DEVICE AND METHOD OF SETTING A MEASUREMENT DEVICE - A measurement device with automatic optimization capabilities comprises at least one signal processing component with a physical detector and a virtual detector component comprising at least one virtual detector for a signal processing component without physical detector. The physical detector is configured to physically measure a measurement value assigned to the signal processing component. The virtual detector component is configured to use a model of a signal processing chain from the physical detector to the location of the virtual detector. The model comprises at least one model parameter for the signal processing chain. The measurement device is configured to adapt the virtual detector component with respect to a measurement type for the signal to be measured. The virtual detector component is configured to use the model and the at least one measurement value. The virtual detector component is configured to determine a virtually determined value based on the model and the at least one measurement value. The measurement device is configured to use the virtually determined value to determine a setting for the measurement device. In addition, a method of setting a measurement device is described. | 2020-12-31 |