53rd week of 2009 patent applcation highlights part 61 |
Patent application number | Title | Published |
20090326181 | Silylated polycarbonate polymers, method of making, and articles - A polycarbonate polymer or copolymer comprising pendant silylated dihydroxy aromatic compound of the formula (1a); | 2009-12-31 |
20090326182 | COMPOSITIONS COMPRISING AN ULTRAVIOLET RADIATION-ABSORBING POLYMER - Ultraviolet radiation-absorbing polymers having a first pendant group that comprises an ultraviolet radiation-absorbing moiety and a second pendant group that comprises at least one siloxane linkage and/or an intermediate length carbon chain are disclosed. Personal care compositions including the ultraviolet radiation-absorbing polymer are provided. | 2009-12-31 |
20090326183 | BRANCHED POLYCARBONATE-POLYSILOXANE COPOLYMERS AND PROCESSES FOR PRODUCING THE SAME - Methods for making a branched polycarbonate-polysiloxane copolymer are provided. An interfacial mixture comprising water, an organic solvent, a polyhydric branching agent, a non-siloxane-containing dihydroxy compound, an endcapping agent, a phase transfer catalyst, and a base is formed. The base and the branching agent are dissolved in the mixture before the non-siloxane-containing dihydroxy compound is added and the interfacial mixture has a basic pH. A first carbonate precursor is added to the interfacial mixture while maintaining the pH at from about 3 to about 9 to form a branched polycarbonate mixture. Next, the pH is increased to from about 8 to about 13 and a siloxane oligomer is added to the branched polycarbonate mixture. The branched polycarbonate mixture is then reacted to form the branched polycarbonate-polysiloxane copolymer. The resulting branched copolymer contains 20 ppm or less of residual chloride, is transparent, has improved flow properties, and has good flame retardance at thin wall thicknesses. | 2009-12-31 |
20090326184 | POLYCARBONATE COPOLYMER, METHOD FOR PRODUCING THE SAME, MOLDED BODY, OPTICAL MATERIAL, AND ELECTROPHOTOGRAPHIC PHOTOSENSITIVE BODY - A polycarbonate copolymer contains: 0.1 to 50 mol % of a monomer unit represented by the following formula (1); and a monomer unit represented by the following formula (2). In the polycarbonate copolymer, the content of biphenols having a structure represented by the following formula (3) is 90 mass ppm or less. | 2009-12-31 |
20090326185 | STORAGE STABLE MELAMINE-UREA-FORMALDEHYDE RESINS AND APPLICATIONS THEREOF - Melamine-urea-formaldehyde resins may be prepared using processes including a first cook stage, a second cook stage, and a final addition wherein: the molar ratio of formaldehyde to urea and melamine (F:U+M) in the first cook stage is from about 2.0 to about 5.0; and the molar ratio of formaldehyde to urea and melamine (F:U+M) in the second cook stage is from about 1.5 to 3.0; and the molar ratio of formaldehyde to urea and melamine (F:U+M) in the final addition from about 0.4 to 0.70. | 2009-12-31 |
20090326186 | MESOGEN CONTAINING COMPOUNDS - Compounds including at least one mesogenic substructure and at least one long flexible segment and methods of synthesizing the same are disclosed. Formulations which include various embodiments of the mesogen containing compounds and their use in articles of manufacture and ophthalmic devices are also disclosed. | 2009-12-31 |
20090326187 | SYNTHESIS OF THIENO[3,4-b]THIOPHENE, THIENO[3,4-b]FURAN, RELATED COMPOUNDS AND THEIR DERIVATIVES AND USE THEREOF - Inexpensive and facile methods of preparing fused heterocycles such as thieno[3,4-b]thiophene, thieno[3,4-b]furan, related compounds, and their derivatives are disclosed. Also disclosed are regioregular polymers prepared from the fused heterocycles. | 2009-12-31 |
20090326188 | Method for producing polyarylene - A method for producing a polyarylene comprising polymerizing only a dihalobiphenyl compound represented by the formula (1): | 2009-12-31 |
20090326189 | PROCESS FOR CONTINUOUS PRODUCTION OF EPOXY RESINS - An epoxy resin with amine functionality is manufactured continuously through a first reaction zone in which an epoxide-functional resin is made by ring-opening addition, a second reaction zone in which the resin is reacted with amine to make an epoxide-functional product, and a third reaction zone in which the epoxide functional product is reacted with amine to make the epoxy resin with amine functionality. In other embodiments, some amine may be added in the first reaction zone to produce an epoxide functional product, with elimination of the second reaction zone, or all of the amine reactant may be added in the first reaction zone to produce an amine functional product, with elimination of both the second and third reaction zones. Optionally, solvent may be removed in an evaporation zone and recycled into the continuous process and further zones may be included to incorporate crosslinker, additives, and to emulsify the resin. | 2009-12-31 |
20090326190 | HEAT SETTING OPTICAL FILMS - A method of making an optical film includes providing a film, substantially uniaxially orienting the film, and heat setting the oriented film. The film includes a polymeric material capable of developing birefringence. | 2009-12-31 |
20090326191 | WATER REPELLENT POWDER DRYING METHOD, PRODUCING METHOD, AND PRODUCING APPARATUS - A semi-finished product obtained as a mixture of PTFE powder and water is put on conveyance trays ( | 2009-12-31 |
20090326192 | BIOLOGICALLY ACTIVE PEPTIDOMIMETIC MACROCYCLES - The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications. | 2009-12-31 |
20090326193 | STABILIZING ALKYLGLYCOSIDE COMPOSITIONS AND METHODS THEREOF - The present invention relates to alkylglycoside-containing compositions and methods for preventing loss of a parathyroid hormone (PTH) analog or octreotide via denaturation due to adherence upon contact with glass. | 2009-12-31 |
20090326194 | PROCESS FOR PREPARING MACROCYCLIC COMPOUNDS - Disclosed is a process for preparing a macrocyclic compound of the formula (I) wherein a hydroxyl-substituted macrocyclic compound of formula (3) is reacted with a sulfonyl-substituted compound of formula QUIN: | 2009-12-31 |
20090326195 | Process for the manufacture of peptides - A process for manufacturing a cyclic peptide which comprises providing a cyclic peptide bonded to a Merrifield-type resin and cleaving the cyclic peptide from the Merrifield type resin by transesterification. | 2009-12-31 |
20090326196 | Proteins Containing a Fluorinated Amino Acid, and Methods of Using Same - One aspect of the invention relates to a polypeptide comprising at least one fluorinated amino acid. Another aspect of the invention relates to a method for modifying a first polypeptide, comprising replacing at least one amino acid in said first polypeptide with a fluorinated amino acid, thereby producing a second polypeptide with increased stability relative to said first polypeptide. | 2009-12-31 |
20090326197 | IFBM's to Promote the Specific Attachment of Target Analytes to the Surface of Orthopedic Implants - The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material (“implant module”) and at least one binding module that selectively binds to a target analyte or that is designed to have a desired effect (“analyte module”). The modules are connected by a linker. In some embodiments, the IFBM coating acts to promote the recognition and attachment of target analytes to surface of the device. The IFBM coating improves the performance of implanted medical devices, for example, by promoting osteointegration of the implant. | 2009-12-31 |
20090326198 | IFBM's to Promote the Specific Attachment of Target Analytes to the Surface of Orthopedic Implants - The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material (“implant module”) and at least one binding module that selectively binds to a target analyte or that is designed to have a desired effect (“analyte module”). The modules are connected by a linker. In some embodiments, the IFBM coating acts to promote the recognition and attachment of target analytes to surface of the device. The IFBM coating improves the performance of implanted medical devices, for example, by promoting osteointegration of the implant. | 2009-12-31 |
20090326199 | IFBM's to Promote the Specific Attachment of Target Analytes to the Surface of Orthopedic Implants - implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material (“implant module”) and at least one binding module that selectively binds to a target analyte or that is designed to have a desired effect (“analyte module”). The modules are connected by a linker. In some embodiments, the IFBM coating acts to promote the recognition and attachment of target analytes to surface of the device. The IFBM coating improves the performance of implanted medical devices, for example, by promoting osteointegration of the implant. | 2009-12-31 |
20090326200 | Altered ospa of borrelia burgdorferi - Provided herein are OspA polypeptides from Lyme Disease-causing | 2009-12-31 |
20090326201 | Affinity Adsorbents for Fibrinogen - For the separation, removal, isolation, purification, characterisation, identification or quantification of fibrinogen or a protein that is a fibrinogen analogue, an affinity adsorbent is used that is a compound of formula II wherein one X is N and the other is N, C—Cl or C—CN; Y is O, S or NR | 2009-12-31 |
20090326202 | ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9) - Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described. | 2009-12-31 |
20090326203 | Framework Selection - The present invention relates to improved methods for the selection of appropriate human acceptor framework regions for non-human (donor) antibodies and methods for obtaining humanized antibodies of high affinity using such acceptor frameworks. | 2009-12-31 |
20090326204 | INTERFERON-LIKE PROTEIN ZCYTO21 - The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides. | 2009-12-31 |
20090326205 | ANTI-HUMAN Dlk-1 ANTIBODY SHOWING ANTI-TUMOR ACTIVITY IN VIVO - The present invention provides an antibody specifically against hDlk-1 and having anti-tumor activity in vivo (an anti-hDlk-1 antibody), a fragment of the antibody, a hybridoma that produces the antibody, a complex of the antibody or antibody fragment and an agent, a pharmaceutical composition comprising the antibody and the like, a tumor therapeutic agent, a tumor angiogenesis inhibitor, a tumor diagnostic agent, a method for detecting a tumor, a kit for detecting and/or diagnosing a tumor, etc. | 2009-12-31 |
20090326206 | Single-chain Multiple Antigen-binding Molecule, Its Preparation and Use - The present invention relates to a single-chain, multiple antigen-binding molecule with diverse variable domains of a heavy and of a light chain of an immunoglobulin, which are connected in the form of a VH-VL construct, which are in turn connected together via a peptide, and to the preparation and use thereof as pharmaceutical or diagnostic aid. | 2009-12-31 |
20090326207 | Gamma Ray-sensitive Phthalocyanine Compound of Poly Cross-linking Type and Ink Composition Comprising The Same - The present invention relates to phthalocyanine compound of poly cross-linking type which is represented with the below formula 1 and is useful for preventing forgery and alternation due to a rapid velocity being responded to a gamma ray of Neutron, and an ink composition comprising it. | 2009-12-31 |
20090326208 | Methods and compositions for generating recombinant nucleic acid molecules - A method of generating a double stranded (ds) recombinant nucleic acid molecule covalently linked in both strands by contacting two or more ds nucleotide sequences with a topoisomerase under conditions such that both termini of at least one end of a first ds nucleotide sequence are covalently linked by the topoisomerase to both termini of at least one end of a second ds nucleotide sequence is provided. Also provided is a method for generating a ds recombinant nucleic acid molecule covalently linked in one strand, by contacting two or more ds nucleotide sequences with a type IA topoisomerase under conditions such that one strand, but not both strands, of one or both ends of a first ds nucleotide sequence are covalently linked by the topoisomerase. Compositions for performing such methods, and compositions generated from such methods also are provided, as are kits containing components useful for conveniently practicing the methods. | 2009-12-31 |
20090326209 | Method for isolating and modifying DNA from blood and body fluids - This invention is related a method for rapidly isolating and modifying DNA from plasma/serum and body fluids. This invention provides a procedure and composition to obtain a high yield of modified DNA for methylation-specific PCR assay by coupling DNA isolation and modification courses. | 2009-12-31 |
20090326210 | POROUS RESIN BEADS AND METHOD OF PRODUCING NUCLEIC ACID USING THE SAME - The present invention provides porous resin beads containing an aromatic monovinyl compound-divinyl compound-(meth)acrylamide derivative copolymer. Preferably, the copolymer further contains as a structural unit a second aromatic monovinyl compound having a functional group capable of binding to a carboxyl group by a dehydrating condensation reaction. | 2009-12-31 |
20090326211 | Process for concentrating and processing fluid samples - A method of treating a liquid sample having microbiological target species therein to concentrate the species and collect lysate is disclosed. The liquid sample comprises non-target microbiological particles, inorganic particles, and microbiological target species. The liquid is passed through a prefilter medium to allow the target species to pass through as filtrate and retain non-target microbiological products and inorganic particles thereon. The filtrate is contacted with a main filtration medium adapted to retain the target species thereon as retentate. The retentate is lysed to form a lysate containing target material that was enveloped within the microbiological target species. The microbiological species may comprise cell containing or viral material. Target materials comprise intracellular nucleic acids, or in the case of viral sampling, nucleic acids encased within the protein sheath or coating of the virus. | 2009-12-31 |
20090326212 | METHOD AND APPARATUS FOR PARALLEL SYNTHESIS OF CHAIN MOLECULES SUCH AS DNA - Synthesis of chain molecules such as DNA is carried out in a conduit having an interior channel with an inlet end and an outlet end. At least one wall of the conduit is substantially transparent to selected wavelengths of light. Solid carrier particles are contained within the interior channel of the conduit. A plurality of controllable light sources are mounted at spaced locations along the length of the transparent wall of the conduit to allow selective illumination of separated sections of the particles within the conduit. When a light source is turned on, a photodeprotecting group is removed from the carrier particles in the section that is illuminated by the light source. A reagent containing a selected base is flowed through the conduit so that the base will attach to the carrier particles in those sections which have been exposed to light and deprotected. | 2009-12-31 |
20090326213 | PROCESS FOR PRODUCTION OF CRYSTAL OF PURINE NUCLEOSIDE COMPOUND - Crystals of a purine nucleoside compound, particularly crystals of 2′,3′-dideoxyinosine, which have excellent storage stability and have a concentration of phosphate attached to the crystal of 25 ppm or more, may be produce by: (1) preparing an aqueous solution containing phosphate ion (PO | 2009-12-31 |
20090326214 | Crystalline Polymorphs of Gemcitabine Base - The present application provides several crystalline forms of gemcitabine base and methods of making the same. | 2009-12-31 |
20090326215 | GLUCOPYRANOSYL-SUBSTITUTED PHENYL DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE - Glucopyranosyl-substituted benzene derivatives of general formula I | 2009-12-31 |
20090326216 | PROCESS FOR ACYLATING CELLULOSE - The present invention describes a process for acylating polysaccharides, oligosaccharides or disaccharides or derivatives thereof by dissolving these in an ionic liquid and reacting them with a ketene, and also novel acylated polysaccharides, oligosaccharides or disaccharides or derivatives thereof. | 2009-12-31 |
20090326217 | Process for preparing cellulose ether - The invention relates to a process for preparing a cellulose ether wherein the cellulose ether is prepared in the presence of an ether of the formula R1-O—R2 having a boiling point between 40 and 90° C., or of a solvent mixture comprising an ether and having a boiling point between 40 and 90° C., wherein R1 and R2 maybe the same or different and are independently selected from an alkyl group. | 2009-12-31 |
20090326218 | Azepinoindole and Pyridoindole Derivatives as Pharmaceutical Agents - Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors. | 2009-12-31 |
20090326219 | PROCESS FOR MANUFACTURING EXTREMELY PURE BENZAZEPINE DERIVATIVES - A process for the production of extremely pure galanthamine or extremely pure galanthamine derivatives, a start is made from racemic bromine narwedine, which is debrominated under palladium catalysis. In this case, the working-up of the reaction mixture, which is carried out in the presence of oxygen or peroxides so that the palladium catalyst in an insoluble form is converted into an easily separable form, is essential. The further reaction is carried out by reduction of enantiomer-pure narwedine to form enantiomer-pure galanthamine, whereby it is then alkylated or dealkylated so that a corresponding substitution on the ring-nitrogen atom is achieved. By further purification, such as recrystallization, residual portions of palladium of below 5 ppm are achieved, so that direct use as a pharmaceutical raw material is made possible. | 2009-12-31 |
20090326220 | Tetrazole-Substituted Arylamides as P2X3 and P2X2/3 Antagonists - Compounds of the formula I: | 2009-12-31 |
20090326221 | New oxabispidine compunds useful in the treatment of cardiac arrhythmias - There is provided compounds of formula I, | 2009-12-31 |
20090326222 | BENZOTHIAZOLE CYCLOBUTYL AMINE DERIVATIVES - Compounds of formula (I) | 2009-12-31 |
20090326223 | SYNTHESIS OF 2-AMINO-SUBSTITUTED 4-OXO-4H-CHROMEN-8.YL-TRIFLUORO-METHANESULFONIC ACID ESTERS - A method of synthesising a compound of formula (I): wherein R | 2009-12-31 |
20090326224 | THIENO PYRIMIDINE COMPOUNDS - A compound for treating cancer tumors, particularly ovarian cancer tumors, is described, where a fused cyclic pyrimidine having a cancer treating ability is effective to allow selective delivery to a cancerous tumor. | 2009-12-31 |
20090326225 | Novel Process for the Preparation of Hexacyclic Compounds - This invention relates to novel processes for the preparation of compounds of the formula [1], | 2009-12-31 |
20090326226 | METHOD FOR ASYMMETRIC SYNTHESIS - The present invention relates to a process for asymmetric synthesis in the presence of a chiral catalyst comprising at least one complex of a metal of transition group VIII with ligands capable of dimerization via noncovalent bonds, such catalysts and their use. | 2009-12-31 |
20090326227 | Process for the Preparation of Biphosphonic Acids and Salts Thereof - A process for the preparation of biphosphonic acids and pharmaceutical acceptable salts thereof, comprises reacting a carboxylic acid with phosphorous trichloride and phosphorous acid in the presence of an aprotic polar solvent. Formula (I): | 2009-12-31 |
20090326228 | COMPOSITIONS CONTAINING IONIC LIQUIDS AND THEIR USES, IN PARTICULAR IN ORGANIC SYNTHESIS - An ionic liquid is used as liquid matrix for organic synthesis in homogeneous phase on soluble support, the ionic liquid being presented in liquid or solid form at ambient temperature, of formula A | 2009-12-31 |
20090326229 | ALPHA-CARBOLINE DERIVATIVES AND METHODS FOR PREPARATION THEREOF - To provide methods for preparing alpha-carboline derivatives in few steps, as well as conveniently and industrially advantageously. A method for preparation of a compound represented by Formula (II) or a salt thereof, comprising subjecting a compound represented by Formula (I) or a salt thereof to a ring closure reaction in the presence of a palladium catalyst, a ligand, and a base; a method for preparation of a compound represented by Formula (IX) or a salt thereof, comprising subjecting a compound represented by Formula (VII) or a salt thereof to a ring closure reaction in the presence of a palladium catalyst, a ligand, and a base, and subsequently to an aromatization reaction; and methods for preparation of compounds represented by Formulae (XV), (XVII), and (XIX) or a salt thereof, comprising subjecting respective compounds represented by Formulae (II) and (IX) or a salt thereof to a reaction for introducing a leaving group when necessary, and subsequently to a coupling reaction: wherein the symbols respectively represent the same meaning as defined in the present specification. | 2009-12-31 |
20090326230 | PROCESS FOR PREPARING SOLIFENACIN AND ITS SALTS - The present invention relates to solifenacin in solid form and a process for its preparation and to a process for the preparation of (1S)-1-Phenyl-1,2,3,4-tetrahydro-isoquinoline, a key intermediate in the synthesis of solifenacin and its salts. | 2009-12-31 |
20090326231 | PROCESS FOR THE PREPARATION OF 8-HYDROXY-5-[(1R)-1-HYDROXY-2[[(1R)-2-(4-METHOXYPHENYL)-1-METHYLETHYL]AMI- NO]ETHYL]-2(1H)-QUINOLINONE MONOHYDROCHLORIDE - 8-hydroxy-5-[(1R)-1-hydroxy-2[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone monohydrochloride of formula (I) may be conveniently prepared in a diastereomeric pure form from optically pure precursors that are readily available by simple resolution and asymmetric reduction. | 2009-12-31 |
20090326232 | Process for the Preparation of Leukotriene Receptor Antagonist (Montelukast Sodium) - The present invention relates to an improved process for the preparation of [R-(E)]-1-[[[1-[3-[2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]-cyclopropaneacetic acid, monosodium salt of Formula (I). | 2009-12-31 |
20090326233 | 4-PHENYLPIPERIDINE COMPOUNDS - The invention relates to a compound, and pharmaceutically acceptable salts, having the formula I: | 2009-12-31 |
20090326234 | (S)-(-)-Amlodipine Camsylate or Hydrate Thereof And Pharmaceutical Composition Comprising Same - Disclosed is (S)-(−)-amlodipine camsylate or a hydrate thereof having good photostability and high solubility, and a pharmaceutical composition comprising same, which can be efficiently used in treating cardiovascular diseases. | 2009-12-31 |
20090326235 | Solutions of anhydrous lanthanide salts and its preparation - The present invention relates to anhydrous solutions of MX | 2009-12-31 |
20090326236 | METALLIC COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE COMPRISING THE SAME - The present invention relates to a light emitting binuclear transition metal compound of Chemical Formulae 1 and 2, and an organic electroluminescence device including the compound. In the Chemical Formulae 1 and 2, M is selected from Ir, Pt, Rh, Re, and Os, and m is 2, provided that the m is 1 when M is Pt. | 2009-12-31 |
20090326237 | USE OF PT-AND PD-BIS-AND TETRA-CARBON COMPLEXES WITH BRIDGED CARBON LIGANDS IN OLEDS - The use of Pt- and Pd-bis- and tetracarbene complexes with bridged carbene ligands in organic light-emitting diodes, organic light-emitting diodes comprising at least one aforementioned Pt- or Pd-carbene complex, at least one transition metal-carbene complex of the general formula I and/or II, organic light-emitting diodes where the at least one transition metal-carbene complex of the general formula I and/or II is present in the light-emitting layer, a blocking layer for electrons, a blocking layer for excitons and/or a blocking layer for holes, a light-emitting layer comprising at least one aforementioned Pt- or Pd-carbene complex, organic light-emitting diodes comprising at least one inventive light-emitting layer, and devices which comprise at least one inventive organic light-emitting diode. | 2009-12-31 |
20090326238 | ASYMMETRIC DENDRIMERS - Asymmetric light-emitting dendrimers having the formulae: (a) CORE-[DENDRITE1]n[DENDRITE2]m and (b) CORE-[DENDRITE]n are disclosed. | 2009-12-31 |
20090326239 | FERMENTATIVE PREPARATION PROCESS FOR AND CRYSTAL FORMS OF CYTOSTATICS - The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described. | 2009-12-31 |
20090326240 | Iron-Copper Co-Catalyzed Process for Carbon-Carbon or Carbon-Heteroatom Bonding - The present invention relates to a process for creating a Carbon-Carbon bond (C—C) or a Carbon-Heteroatom bond (C—HE) by reacting a compound carrying a leaving group with a nucleophilic compound carrying a carbon atom or a heteroatom (HE) that can substitute for the leaving group, creating a C—C or C—HE bond, wherein the reaction takes place in the presence of an effective quantity of a catalytic system comprising iron and copper. | 2009-12-31 |
20090326241 | PROCESS FOR PREPARING SUBSTITUTED 5-AMINO-PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINES - A process for preparing substituted 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidine compounds having an aminoalkyl substituent at the 7-position is disclosed, wherein the pyrimidine ring is cyclized using a cyanating agent. | 2009-12-31 |
20090326242 | PROCESS FOR PREPARING 3-DIHALOMETHYL-PYRAZOLE-4-CARBOXYLIC ACID DERIVATIVES - The invention relates to a process for preparing 3-dihalomethylpyrazole-4-carboxylic acid derivatives of the formula (I) by reacting α-fluoroamines of the formula (III) in the presence of Lewis acids with acrylic acid derivatives of the formula (II) to give vinamidinium salts of the formula (IV) and the subsequent reaction thereof with hydrazines, and to the vinamidinium salts of the formula (IV) themselves. | 2009-12-31 |
20090326243 | Ligands for transition-metals and methods of use - The present invention relates to indolyl phosphine ligands, and methods of making such ligands utilizing phenyl hydrazines and aryl ketones as the starting material. The present invention further includes uses of the ligands in the synthesis of pharmaceuticals, materials, and agriculture. | 2009-12-31 |
20090326244 | BISULFITE PURIFICATION OF AN ALPHA-KETO AMIDE - A process for purifying the alpha-keto amide is (1R,5S)—N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]-amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide via a bisulfite adduct is disclosed. | 2009-12-31 |
20090326245 | Novel Polymorphs of Azabicyclohexane - The invention provides polymorphic crystalline forms of acid addition salts of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane designated as polymorph form A, polymorph form B and polymorph form C, where polymorph form A is more thermodynamically stable than the other forms, methods for preparing and using such polymorph forms and pharmaceutical compositions containing such polymorph forms. | 2009-12-31 |
20090326246 | Method for Production of Optically Active 3-Amino-Nitrogenated Compound - Aiming at production of an optically active 3-amino nitrogen-containing compound which is useful as an intermediate in synthesis of medicines and pesticides, in particular, an optically active 1-protected-3-aminopyrrolidine derivative, from an inexpensive and readily available raw material by a process which is efficient and can be practiced industrially, an optically active 3-amino nitrogen-containing compound is produced by performing a reaction of an optically active 3-substituted nitrogen-containing compound with ammonia, methylamine, ethylamine or dimethylamine in the presence of water. In addition, a 1-protected-3-aminopyrrolidine derivative is produced by performing a reaction of an optically active 1-protected-3-(sulfonyloxy)pyrrolidine derivative with ammonia, methylamine, ethylamine, or dimethylamine in the presence of methanol, ethanol, n-propanol, or isopropanol under a pressure of less than 30 barr. | 2009-12-31 |
20090326247 | METHOD FOR PRODUCING 2-ALKYL-3-AMINOTHIOPHENE DERIVATIVE - The present invention provides a method of producing a 2-alkyl-3-aminothiophene derivative represented by formula (2) by reducing at least one of the 2-alkenyl-3-aminothiophene derivatives represented by formulae (1a) to (1d), or a mixture thereof, or a salt thereof, without using a protecting group for an amino group: | 2009-12-31 |
20090326248 | USE OF SPECIFIC CYKLOLIGNANS - The invention refers to the use of specific cyclolignans, wherein the carbon atoms in positions 9 and 9′ have cis configuration, for inhibition of the insulin-like growth factor-1 receptor. Said compounds can be used for treatment of IGF-1R dependent diseases, such as cancer, psoriasis, artherosclerosis and acromegaly. A preferred compound is picropodophyllin. | 2009-12-31 |
20090326249 | Process for Preparation of Citalopram and Enantiomers - The present invention provides a process for preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile comprising reacting a compound of formula IVa, in the presence of a base with a compound of formula RX, | 2009-12-31 |
20090326250 | METHOD FOR PRODUCING PROPYLENE OXIDE - A method for producing propylene oxide according to the present invention comprises a step of reacting propylene with oxygen in the presence of water, a halogen compound, and a silver catalyst containing alkaline earth metal carbonate as a support, the silver catalyst having 10 μmol/g or more oxygen adsorption capacity. This provides an industrially advantageous method for producing olefin oxide. | 2009-12-31 |
20090326251 | METHODS FOR PREPARING 17-ALKYNYL-7-HYDROXY STEROIDS AND RELATED COMPOUNDS - The invention relates to processes for preparing 17-alkynyl-7-hydroxy-steroids, such as 17-Ethynyl-10R,13S-dimethyl 2,3,4,7,8R,9S, 10,11,12,13,14S,15,16,17-hexadecahydro-1H-cyclopenta[a]phenanthrene-3R,7R,17S-triol (also referred to as 17α-ethynyl-androst-5-ene-3β,7β,17β-triol), that are essentially free of process impurities having binding activity at nuclear estrogen receptors. | 2009-12-31 |
20090326252 | PROCESS OF MANUFACTURING OF FATTY ACID ALKYL ESTERS - Processes for preparation of fatty acid alkyl esters are described herein. The processes include contacting fatty acid glycerides with alcohols in the presence of a catalyst separating the reaction products from the catalyst, and separating the fatty acid alkyl esters from the reaction products. The catalyst includes a metal from Group VIB of the Periodic Table, a metal from Group IIIA of the Periodic Table, and an element from Group VA of the Periodic Table. | 2009-12-31 |
20090326253 | NOVEL PHOSPHINE LIGANDS - The invention is concerned with new phosphine ligands of the formula I | 2009-12-31 |
20090326254 | ORGANIC-METAL PRECURSOR MATERIAL AND METHOD OF MANUFACTURING METAL THIN FILM USING THE SAME - Provided are an organic-metal precursor material that can be readily decomposed without reacting with an oxidant, a method of manufacturing a metal thin film using the organic-metal precursor material, and a metal thin film prepared using the organic-metal precursor material. The organic-metal precursor material is an organic molecule having lone-pair electrons selected from the group consisting of ether, amine, tetrahydrofuran (THF), a phosphine group, and a phosphite group, and has a structure of covalent coordination bond. | 2009-12-31 |
20090326255 | METHOD FOR MAKING ALKOXY-MODIFIED SILSESQUIOXANES AND AMINO ALKOXY-MODIFIED SILSESQUIOXANES - A method is presented for making an amino alkoxy-modified silsesquioxane (amino AMS) comprising one or more compounds selected from the group consisting of an amino-AMS, an amino/mercaptan co-AMS, an amino/blocked mercaptan co-AMS, and mixtures of these. The use of solid strong cationic catalysts in this reaction system is advantageous because the catalyst remains as a solid throughout the reaction, allowing simplified separation of the solid catalyst from the soluble amino AMS or amino co-AMS products, resulting in total or near total recovery of the amino AMS or amino co-AMS products, as well as virtual total recovery of the catalyst for recycling. The use of the solid strong cationic catalysts is advantageous because it results in amino AMS products that are free of, or substantially free of, residual acid catalyst. | 2009-12-31 |
20090326256 | ANALGESIC AGENT COMPRISING CYCLIC PHOSPHATIDIC ACID DERIVATIVE - An object of the present invention is to elucidate an analgesic effect as one of new cPA bioactivities and thus to provide a novel analgesic agent. The present invention provides an analgesic agent which comprises a cyclic phosphatidic acid derivative that is one type of phospholipid. | 2009-12-31 |
20090326257 | Process for industrially producing dialkyl carbonate and diol - It is an object of the present invention to provide a specific process that enables dialkyl carbonates and diols to be produced on an industrial scale of not less than 2 ton/hr and not less than 1.3 ton/hr respectively with high selectivity and high productivity stably for a prolonged period of time through a reactive distillation system of taking cyclic carbonates and aliphatic monohydric alcohols as starting materials, continuously feeding the starting materials into a continuous multi-stage distillation column in which a catalyst is present, and carrying out reaction and distillation simultaneously in the column. Although there have been many proposals regarding processes for the production of the dialkyl carbonates and the diols through a reactive distillation method, these have all been on a small scale and short operating time laboratory level, and there have been no disclosures whatsoever on a specific process or apparatus enabling mass production on an industrial scale. According to the present invention, there are provided a specific continuous multi-stage distillation column having a specified structure, and a production process using this continuous multi-stage distillation column, in which the dialkyl carbonates and the diols can be produced on an industrial scale of not less than 2 ton/hr and not less than 1.3 ton/hr respectively each with a selectivity of not less than 95%, preferably not less than 97%, more preferably not less than 99%, with a high yield stably for not less than 1000 hours, preferably not less than 3000 hours, more preferably not less than 5000 hours. | 2009-12-31 |
20090326258 | PROCESS FOR THE PREPARATION OF SUBSTITUTED TETRALIN AND SUBSTITUTED INDANE DERIVATIVES - The present invention relates to novel processes for the preparation of substituted tetralin and substituted indane derivatives. The present invention is further directed to novel processes for the preparation of intermediates in the preparation of the substituted tetralin and substituted indane derivatives. | 2009-12-31 |
20090326259 | NF-Kappabeta Activation Inhibitor - The object is to provide a highly safe NF-κB activation inhibitor at a low cost which can be used for prevention and treatment of diseases associated with the activation of NF-κB such as inflammation or type-2 diabetes. Specifically, the NF-κB activation inhibitor comprises a compound represented by the chemical structural formula depicted in the following Chemical Formula 1 [wherein R | 2009-12-31 |
20090326260 | Conversion of Nitrile Compounds Into Carboxylic Acids and Corresponding Esters Thereof - Hydrocarbon-based compounds containing at least one nitrile function are converted into compounds containing at least one carboxylic function, and into ester compounds from the carboxylic compounds thus obtained; such conversion entails reacting the nitrile compound with a hydroxyl basic compound in solution in a solvent at a temperature of between 80 and 150° C., in eliminating the ammonia formed, in reacting the salt obtained with a mineral acid, and then in recovering the compound containing at least one carboxylic function and, optionally, esterifying the acids obtained by reaction with an alcohol. | 2009-12-31 |
20090326261 | PREPARATION OF DIESTERS FROM IMIDE/DINITRILE COMPOUNDS - Diester compounds are prepared from imide/dinitrile compounds employing a vapor-phase hydrolysis of dinitrile compounds in the presence of alcohol, more particularly from branched dinitrile compounds, such as methylglutaronitrile or branched dinitrile compounds obtained as by-products in a process for the production of adiponitrile by hydrocyanation of butadiene. | 2009-12-31 |
20090326262 | METAL UTILIZATION IN SUPPORTED, METAL-CONTAINING CATALYSTS - Generally, the present invention relates to improvements in metal utilization in supported, metal-containing catalysts. For example, the present invention relates to methods for directing and/or controlling metal deposition onto surfaces of porous substrates. The present invention also relates to methods for preparing catalysts in which a first metal is deposited onto a support (e.g., a porous carbon support) to provide one or more regions of a first metal at the surface of the support, and a second metal is deposited at the surface of the one or more regions of the first metal. Generally, the electropositivity of the first metal (e.g., copper or iron) is greater than the electropositivity of the second metal (e.g., a noble metal such as platinum) and the second metal is deposited at the surface of the one or more regions of the first metal by displacement of the first metal. The present invention further relates to treated substrates, catalyst precursor structures and catalysts prepared by these methods. The invention further relates to use of catalysts prepared as detailed herein in catalytic oxidation reactions, such as oxidation of a substrate selected from the group consisting of N-(phosphonomethyl)iminodiacetic acid or a salt thereof, formaldehyde, and/or formic acid. | 2009-12-31 |
20090326263 | Process for the preparation of aniline-derived thyroid receptor ligands - Provided are processes for the synthesis of aniline derivatives, specifically certain aniline derivatives which have activity as thyroid receptor ligands. | 2009-12-31 |
20090326264 | REDUCING METHOD OF WATER FROM REACTOR OUTLET GAS IN THE OXIDATION PROCESS OF AROMATIC COMPOUND - The present invention relates to a method of reducing water from the reactor outlet gas in the oxidation process of an aromatic compound, for example, in the preparation of terephthalic acid by oxidation of xylene in an acetic acid solvent. As water is removed from the reactor outlet gas at the first absorption tower, the amount of water inflow to the dehydration tower is reduced and, thus, the amount of steam required to separate water and acetic acid at the dehydration tower is reduced and the load of the dehydration tower can be decreased. Further, by carefully controlling the flow amount of the reactor outlet gas to the first absorption tower, the operation of the dehydration tower may be made unnecessary. | 2009-12-31 |
20090326265 | PROCESS FOR PREPARING AROMATIC POLYCARBOXYLIC ACID BY LIQUID PHASE OXIDATION - The invention relates to a process for preparing an aromatic polycarboxylic acid by liquid phase oxidation of a di- or tri-substituted benzene or naphtalene compound, the process comprising a step of contacting the aromatic compound with an oxidant in the presence of a carboxylic acid solvent, a metal catalyst and a promoter in a reaction zone, wherein the promoter is an ionic liquid comprising an organic cation and a bromide or iodide anion. Advantages of this process include high conversion without severe corrosion problems otherwise associated with halogen-containing compounds as promoter. The process does not necessitate the use of special corrosion-resistant material or liners in the process equipment; thus offering savings on investment and maintenance costs and increasing plant reliability. | 2009-12-31 |
20090326266 | PROCESS FOR THE PREPARATION OF GABAPENTIN - A process for the preparation of 1,1-cyclohexanediacetic acid monoamide comprising the amination of 1,1-cyclohexanediacetic acid anhydride by reaction with aqueous NH | 2009-12-31 |
20090326267 | PROCESS FOR THE PREPARATION OF A GRANULAR MICROBIAL BIOMASS AND ISOLATION OF A COMPOUND THEREFROM - A process for the isolation of desired compound(s) from a microbial biomass is disclosed, wherein the microbial biomass (which, if necessary, is pretreated to give a dry matter content of from 25 to 80%) is granulated (e.g. by extrusion) and then dried to a dry matter content of at least 80%. The granulation of the biomass to granules significantly eases subsequent drying of the biomass (which can be stored as dried granules) and gives higher yields on extraction of the compound(s). | 2009-12-31 |
20090326268 | COMPOSITIONS FOR CARBOXYLIC ACID PRODUCTION AND METHODS FOR MAKING AND USING SAME - An alcohol such as methanol is reacted with carbon monoxide in a liquid reaction medium including a catalyst, an alkyl iodide such as methyl iodide, alkyl acetate such as methyl acetate in specified proportions, an additive, and an effective amount of water, where the additive increases an ionic character of the hydrogen iodide bond and the effective amount of water is sufficient to facilitate carboxylic acid release after carbonylation at the catalyst and to reduce anhydride formation. The present reaction system not only provides an acid product at water levels considerable below levels currently used, but also provides unexpected reaction rates and unexpected high catalyst stability. | 2009-12-31 |
20090326269 | Templated Monolayer Polymerization and Replication - A self-replicating monolayer system employing polymerization of monomers or nanoparticle ensembles on a defined template provides a method for synthesis of two-dimensional single molecule polymers. Systems of self-replicating monolayers are used as templates for growth of inorganic colloids. A preferred embodiment employs SAM-based replication, wherein an initial monolayer is patterned and used as a template for self-assembly of a second monolayer by molecular recognition. The second monolayer is polymerized in place and the monolayers are separated to form a replicate. Both may then function as templates for monolayer assemblies. A generic self-replicating monomer unit comprises a polymerizable moiety attached by methylene repeats to a recognition element and an ending unit that will not interfere with the chosen recognition chemistry. The recognition element is self-complementary, unless a set of two replicating monomers with compatible cross-linking chemistry is employed. In a two-component replication system utilizing two different kinds of recognition chemistries, the initial template undergoes replication cycles, while maintaining two-dimensional segregation of the two types of monomers. During subsequent replications, the component domains experience little or no mixing, allowing the two-component, patterned assembly to be exponentially replicated. After replication, selective mineralization and/or electroless plating may produce a two-dimensional inorganic sheet having patterned domains within it. | 2009-12-31 |
20090326270 | ACTIVATED CARBON MONOLITH CATALYST, METHODS FOR MAKING SAME, AND USES THEREOF - An activated carbon monolith catalyst comprising a finished self-supporting activated carbon monolith having at least one passage therethrough, and comprising a supporting matrix and substantially discontinuous activated carbon particles dispersed throughout the supporting matrix and at least one catalyst precursor on the finished self-supporting activated carbon monolith. A method for making, and a method for use, of such an activated carbon monolith catalyst in catalytic chemical reactions are also disclosed. | 2009-12-31 |
20090326271 | Preparation of 3-[(1R,2R)-3-(Dimethylamino)-1Ethyl-2-Methylpropyl]phenol - The present invention relates to an improved process for the preparation of 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol monohydrochloride. | 2009-12-31 |
20090326272 | Method for Producing Optically Active 1-(Fluoro-, Trifluoromethyl- or Trifluoromethoxy-Substituted Phenyl) Alkylamine N-Monoalkyl Derivative - There is provided a method for producing an optically active 1-(fluoro-, trifluoromethyl- or trifluoromethoxy-substituted phenyl)alkylamine N-monoalkyl derivative, which includes the steps of conducting reductive alkylation of an optically active secondary amine and a formaldehyde (including an equivalent thereof) or lower aldehyde in the presence of a transition metal catalyst under a hydrogen gas atmosphere, thereby converting the secondary amine to an optically active tertiary amine of the formula, and subjecting the tertiary amine to hydrogenolysis. The target optically active compound can be produced efficiently by this production method. | 2009-12-31 |
20090326273 | IONIC BRONSTED ACID - A new ionic compound is provided that is derived from N,N-dimethylaniline and pentafluorophenol in amounts such that there are at least 2 equivalents of pentafluorophenol per equivalent of the N,N-dimethylaniline. | 2009-12-31 |
20090326274 | Sulphonylated Diphenylethylenediamines, Method for Their Preparation and Use in Transfer Hydrogenation Catalysis - A diamine of formula (I) is described in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X | 2009-12-31 |
20090326275 | USE OF NITROGEN-CONTAINING CURCUMIN ANALOGS FOR THE TREATMENT OF ALZHEIMERS DISEASE - A curcumin analog in which natural curcumin is modified by an amino acid moiety that increases the analog's transport across the blood brain barrier by the LAT1 transporter. | 2009-12-31 |
20090326276 | METHOD FOR THE PRODUCTION OF CYCLIC KETONES - The present invention relates to a process for preparing a cyclic ketone having from 7 to 16 carbon atoms, which comprises at least the steps | 2009-12-31 |
20090326277 | METHOD FOR PURIFYING CYCLIC KETONES - The present invention relates to a process for purifying a composition (I) comprising at least one cyclic ketone having from 7 to 16 carbon atoms, which comprises thermal treatment of the composition (I) with at least one acid and further purification by means of a process selected from the group consisting of distillation, extraction and crystallization, Furthermore, the present invention relates to a process for preparing cyclododecanone, which comprises such a purification, and the use of at least one acid for purifying a composition (I) comprising at least one cyclic ketone having from 7 to 16 carbon atoms by thermal treatment of the composition (I) with the acid. | 2009-12-31 |
20090326278 | Modified carbon nanoparticles, method for the production thereof and use thereof - The present invention relates to novel carbon nanoparticles, especially to carbon nanoparticles which comprise or consist of carbon nanotubes and have been modified by means of acyl groups, to a novel process with which these modified carbon nanoparticles, especially carbon nanoparticles comprising or consisting of carbon nanotubes, are obtainable, and to the use of the modified carbon nanoparticles, especially carbon nanoparticles comprising or consisting of carbon nanotubes. | 2009-12-31 |
20090326279 | Support for use in microchannel processing - The disclosed technology relates to an apparatus, comprising: at least one microchannel, the microchannel comprising at least one heat transfer wall; a porous thermally conductive support in the microchannel in contact with the heat transfer wall; a catalyst or a sorption medium supported by the porous support; and a heat source and/or heat sink in thermal contact with the heat transfer wall. | 2009-12-31 |
20090326280 | Systems and Methods for the Preparation of Alkyl Aryl Ethers - A process for the preparation of alkyl aryl ethers from alcohols and aryl halides, usually as intermediates in organic synthesis. In a method, the mixing aryl halide and an alcohol is mixed with dimethyl sulfoxide, water, and a metal hydroxide to form a mixture and the mixture is heated to reflux. Additional steps may then be performed to provide for purification. | 2009-12-31 |