| 52nd week of 2021 patent applcation highlights part 42 |
| Patent application number | Title | Published |
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| 20210404972 | METHODS AND SYSTEMS FOR DETERMINING AN IONIC STRENGTH OF A DILUTE AQUEOUS SOLUTION - Disclosed herein are methods for measuring the ionic strengths of the natural water sources. Also disclosed herein are systems used to measure an ionic strength of the natural water sources. More specifically disclosed herein are methods and systems utilizing spectroscopic pH measurements and calculations of the ionic strength as a function of the measured pH. | 2021-12-30 |
| 20210404973 | METHOD AND ELECTRONIC APPARATUS FOR DISPLAYING INSPECTION RESULT OF BOARD - An electronic apparatus including a display and one or more processor is disclosed. The one or more processor is configured to: divide a first error value of each of a plurality of first components with respect to a mounting position acquired through inspection of a plurality of substrates of a first type, into a plurality of error values, generate a graph of a tree structure including a plurality of nodes corresponding to the plurality of first components, component types of each of the plurality of first components and a plurality of components included in a mounter, adjust attributes of each of the plurality of nodes using the plurality of error values divided from the first error value of each of the plurality of first components, and display the graph in which the attributes of each of the plurality of nodes are adjusted, on the display. | 2021-12-30 |
| 20210404974 | DYNAMIC IMAGING QUALITY CONTROL DEVICE, STORAGE MEDIUM, AND DYNAMIC IMAGING QUALITY CONTROL METHOD - Provided is a dynamic imaging quality control device that performs quality control concerning dynamic imaging in which dynamics of a subject is imaged by sequential radiation emissions to the subject. The dynamic imaging quality control device includes a hardware processor. The hardware processor presents information on the quality control. The information on the quality control includes at least one of information on a framerate, information on a system sensitivity, and information on an image region. | 2021-12-30 |
| 20210404975 | TWO-STEP MATERIAL DECOMPOSITION CALIBRATION METHOD FOR A FULL SIZE PHOTON COUNTING COMPUTED TOMOGRAPHY SYSTEM - A method and a system for providing calibration for a photon counting detector forward model for material decomposition. The flux independent weighted bin response function is estimated using the expectation maximization method, and then used to estimate the pileup correction terms at each tube voltage setting for each detector pixel. | 2021-12-30 |
| 20210404976 | CALIBRATION METHOD FOR X-RAY MEASURING DEVICE - A calibration method for an X-ray measuring device includes mounting a calibration tool on a rotating table, identifying centroid positions from an output of an X-ray image detector, calculating projection transformation matrixes from the centroid positions and known relative positional intervals, repeating to identify the centroid positions from the output of the X-ray image detector and to calculate the projection transformation matrixes from the centroid positions and known relative positional intervals while the rotating table is rotated twice or more by a predetermined angle, and calculating a rotation center position of the rotating table on the basis of the projection transformation matrixes. The calibration method thereby allows easy calculation of the rotation center position of the rotating table on which an object to be measured is mounted in a rotatable manner, with the simple process. | 2021-12-30 |
| 20210404977 | SAMPLE HOLDER, SYSTEM AND METHOD - A sample holder for holding a sample during an X-ray imaging process includes a sample placement surface on which the sample is placed for positioning the sample in a depth direction of the sample holder. The sample holder also includes a first alignment portion for aligning the sample in a width direction of the sample holder, and a second alignment portion for aligning the sample in a height direction of the sample holder. | 2021-12-30 |
| 20210404978 | METHOD FOR DIFFRACTION PATTERN ACQUISITIONMETHOD FOR DIFFRACTION PATTERN ACQUISITION - Methods and systems for conducting tomographic imaging microscopy of a sample with a high energy charged particle beam include irradiating a first region of the sample in a first angular position with a high energy charged particle beam and detecting emissions resultant from the charged particle beam irradiating the first region. The sample is repositioned into a second angular position such that the second region to be different than the first region, and a second region of the sample is irradiated. Example repositioning may include one or more of a translation of the sample, a helical rotation of the sample, the sample being positioned in a non-eucentric position, or a combination thereof. Emissions resultant from irradiation of the second region are then detected, and a 3D model of a portion of the sample is generated based at least in part on the detected first emissions and detected second emissions. | 2021-12-30 |
| 20210404979 | Soft X-Ray Optics With Improved Filtering - Optical elements that efficiently propagate x-ray radiation over a desired energy range and reject radiation outside the desired energy range are presented herein. In one aspect, one or more optical elements of an x-ray based system include an integrated optical filter including one or more material layers that absorb radiation having energy outside the desired energy band. In general, the integrated filter improves the optical performance of an x-ray based system by suppressing reflectivity within infrared (IR), visible (vis), ultraviolet (UV), extreme ultraviolet (EUV) portions of the spectrum, or any other undesired wavelength region. In a further aspect, one or more diffusion barrier layers prevent degradation of the integrated optical filter, prevent diffusion between the integrated optical filter and other material layers, or both. In some embodiments, the thickness of one or more material layers of an integrated optical filter vary over the spatial area of the filter. | 2021-12-30 |
| 20210404980 | SMOKE POINT AUTOMATIC CORRECTION - A testing device and method for determining smoke point of a hydrocarbon. The device including: an apparatus for determining the smoke point conforming to specifications of an ASTM D1322-19 standard or equivalent standard, imaging device for taking a series of digital images of a flame; ambient relative humidity sensor for measuring relative humidity; ambient temperature sensor for measuring temperature; computer system linked to the imaging device, humidity sensor, and temperature sensor programmed to analyze digital images from the imaging device to measure flame height flame, and use temperature with relative humidity measured by the temperature and humidity sensors to calculate absolute humidity and correct measured flame height as a function of difference between the calculated absolute humidity and normalized absolute humidity, and preferably to correct measured flame height as a function of difference between pressure during flame height measuring and normalized pressure. | 2021-12-30 |
| 20210404981 | MICRO-ACTUATOR DEFECT DETECTION VIA TEMPERATURE - A method is disclosed for determining whether piezoelectric materials have defects such as cracks. The method includes applying a voltage signal to a piezoelectric micro-actuator, measuring a temperature of the piezoelectric micro-actuator while applying the voltage signal, and determining that the piezoelectric micro-actuator includes a defect based on the measured temperature. | 2021-12-30 |
| 20210404982 | SMART PACKAGING FOR IMPROVED MEDICATION REGIMEN COMPLIANCE - The present disclosure enables apparatus and methods for tracking medications and/or product units via smart-packaging concepts. Embodiments include sensors that monitor the state of a blister-card package having an unpatterned lidding film by measuring the impedance of each dispensing region of the lidding film that defines a portion of a blister. In some embodiments, the impedance is measured via a plurality of contact points arranged on opposite sides of each dispensing region, where the contact points are resistively or capacitively coupled with the lidding film. In some embodiments, the impedance map of a measurement region on the blister card is derived via electrical impedance tomography or electrical resistance tomography, where the measurement region includes a plurality of dispensing regions. | 2021-12-30 |
| 20210404983 | DETECTION CIRCUIT FOR DISPLAY PANEL AND DETECTION METHOD THEREOF - A detection circuit for a display panel that includes a display panel, a flexible printed circuit board (PCB) adapter, and a module lighting fixture, wherein the display panel includes a display area and a non-display area, and the non-display area further accommodates a detection signal wire and a driving integrated circuit (IC). The flexible PCB adapter is disposed at a pin wire of a receiving terminal of the detection signal wire between the display panel and the module lighting fixture. The module lighting fixture is disposed at one end of the flexible PCB adapter. | 2021-12-30 |
| 20210404984 | CONDUCTIVE SENSOR SYSTEMS AND METHODS OF USE THEREOF - The present disclosure provides a sensor system including one or more sensors having a first container fluidly coupled to a second container, the second container being configured to receive a conductive media from the first container. A first movable element is slidingly engaged with the first container to cause the second container to receive the conductive media from the first container. A first electrode is positioned in the first cavity and electrically coupled to the conductive media. In some examples, a second electrode is electrically coupled to the first electrode and the conductive media. The sensor deposits the conductive media on a working electrode to form an electrochemical cell and obtain one or more material properties of the working electrode. In some examples, the sensor system includes an array of sensors which deposit the conducive media in multiple locations on a working electrode to generate a material property map. | 2021-12-30 |
| 20210404985 | GAS SENSOR AND MANUFACTURING METHOD FOR GAS SENSOR - In a gas sensor, a housing is formed into a cylindrical shape. A holding portion is arranged inside the housing and is formed into a cylindrical shape that has a through hole that passes through in an axial direction, when a direction in which an axis of the housing extends is the axial direction. A sensor element is formed to extend in the axial direction in a state where the sensor element passes through the through hole in the holding portion and detects a gas to be measured on one side in the axial direction. A glass seal is arranged inside the holding portion, is made of a glass material, and seals between the sensor element and the holding portion. A shock mitigating portion that mitigates shock being transferred from outside the housing through the holding portion to the glass seal is housed between the housing and the holding portion. | 2021-12-30 |
| 20210404986 | SYSTEMS, METHODS AND TOOLS FOR SUBTERRANEAN ELECTROCHEMICAL CHARACTERIZATION AND ENTHALPY MEASUREMENT IN GEOTHERMAL RESERVOIRS - The present disclosure is directed to systems, methods and tools that measure ionic concentrations and downhole enthalpy of a flowing geothermal fluid in real-time at high-temperature and pressure. The systems, methods and tools include measuring the concentration of selected naturally occurring ions found in the liquid phase of the geothermal fluid throughout the wellbore using novel electrochemical sensor technologies. The change in liquid-phase ion concentration will be used to calculate the proportion of liquid to steam and allow for accurate enthalpy measurements. The techniques and technologies described here can be applied to any application of electrochemical sensing in extreme environments. | 2021-12-30 |
| 20210404987 | CAPILLARY ELECTROPHORESIS APPARATUS AND THERMOSTAT - The capillary electrophoresis apparatus according to the present invention can maintain the temperature in the longitudinal direction of each of a plurality of capillaries uniformly, such that the separation performance of the capillary electrophoresis apparatus can be stabilized, and the analysis performance can be improved. A capillary electrophoresis apparatus according to the present invention includes: a thermostat having a heat source, a first heat conduction member, and a detection window for detecting a sample, the thermostat being configured to maintain a capillary at a predetermined temperature; a capillary holder having a second heat conduction member for sandwiching the capillary between the second heat conduction member and the first heat conduction member, the capillary holder being configured to hold the capillary; and a detection unit configured to detect a sample to be electrophoresed in the capillary, wherein in the heat source, a heat generation amount of at least one of a periphery of the detection window and an end of the capillary is higher than a heat generation amount of another portion. | 2021-12-30 |
| 20210404988 | PULSED SAMPLING-BASED ION MOBILITY SPECTROMETER AND SNIFFER - There are provided an ion mobility spectrometer and a sniffer. The ion mobility spectrometer includes: an ion migration tube; a sampling gas path having a sampling device configured to temporarily store a sample gas collected by a sampling head in a sampling pipe; a sample introduction gas path having two ends in communication with the gas inlet and outlet of the ion migration tube respectively, and configured to introduce a carrier gas within the ion migration tube into the sampling pipe and to carry a sample gas temporarily stored in the sampling pipe into the ion migration tube; and a valve assembly configured to only allow gas to flow from the sampling device to the sampling pipe in a sampling state, and to only allow gas to flow from the ion migration tube through the sampling pipe back to the ion migration tube in a sample introduction state. | 2021-12-30 |
| 20210404989 | GAS SENSOR AND METHOD OF OPTIMIZING AN ARRAY OF GAS SENSORS - A gas sensor ( | 2021-12-30 |
| 20210404990 | DEVICES AND METHODS OF SENSING PROPERTIES OF FLUIDS - The invention discloses methods for simultaneously measuring various properties of a fluid using a waveguide. The method includes transmitting a plurality of wave modes into the fluid using an ultrasonic shear wave transducer from one end of a waveguide. Further, the wave modes are reflected from the other end of the waveguide. The reflected wave modes are processed simultaneously. The time of flight and the amplitude of the received wave modes are determined. Further, one or more properties of the fluid are measured using determined time of flight and amplitude of the received wave modes. The disclosed method is used to accurately measure the properties of fluid such as level, density, viscosity or flow rate in a short period of time. | 2021-12-30 |
| 20210404991 | ULTRASONIC WATER-AGNOSTIC TOUCH DETECTION SENSOR - An ultrasonic touch sensing system that uses both compressional and shear waves for touch and water detection is disclosed. When no touch or water is present, less shear and compressional wave energy is absorbed, so both shear and compressional wave reflections do not have significant amplitude decreases. When a finger is in contact with the sensing plate, both shear and compressional wave energy is absorbed, so both shear and compressional wave reflections have significant amplitude decreases. When water is in contact with the sensing plate, compressional energy is absorbed but little or no shear wave energy is absorbed, so while compressional wave reflections have significant amplitude decreases, shear wave reflections do not. From these amplitudes, a determination can be made as to whether no touch is present on the sensing plate, whether a touch is present on the sensing plate, or whether water is present on the sensing plate. | 2021-12-30 |
| 20210404992 | LAMINATED IRON CORE ELASTIC MATRIX DETERMINATION METHOD AND VIBRATION ANALYSIS METHOD - An elastic matrix determination method for a laminated iron core, which can optimally determine a shear modulus in two planes including a laminating direction of the laminated iron core included in an elastic matrix in a constitutive equation representing a stress-strain relationship used for vibration analysis, and also provided is a vibration analysis method. When performing a vibration analysis of a laminated iron core formed by laminating steel sheets using a constitutive equation representing a stress-strain relationship in a matrix representation, a shear modulus in two planes including a laminating direction of the laminated iron core included in an elastic matrix in the constitutive equation is determined depending on an average tightening pressure in the laminating direction of the laminated iron core. | 2021-12-30 |
| 20210404993 | TESTING METHODOLOGY TO MONITOR THE ON-SET OF SOLID ACID HYDROLYSIS USING SONIC WAVES - A method for testing solid acid hydrolysis in a formation. The method includes introducing a test sample into a test cell, where the test sample includes an upper structure, a lower structure, and a solid acid disposed between the upper and lower structures. The pressure and temperature of the test cell are increased to simulate downhole conditions. A velocity of an acoustic p-wave and/or acoustic s-wave is through the test sample is measured while the temperature is increasing from an initial temperature to a final temperature. A temperature of onset of solid acid hydrolysis based on the measured velocity is determined. | 2021-12-30 |
| 20210404994 | HEATERS IN CAPACITIVE MICROMACHINED ULTRASONIC TRANSDUCERS AND METHODS OF FORMING AND ACTIVATING SUCH HEATERS - Aspects of the technology described herein relate to a capacitive micromachined ultrasonic transducer (CMUT) and a heater disposed in the CMUT, and forming a capacitive micromachined ultrasonic transducer (CMUT) and a heater disposed in the CMUT. A voltage may be applied to a heater disposed in a CMUT in an ultrasound imaging device in order to cause the heater to generate heat. Based on determining that the collapse voltage of the CMUT has increased by at least a threshold voltage between two times, a voltage may be automatically applied to a heater in the CMUT such that the heater generates heat. | 2021-12-30 |
| 20210404995 | System and Method of Trace-Level Analysis of Chemical Compounds - Techniques disclosed herein can be used to perform a rapid, splitless injection of a sample including SVOCs and VOCs. In some embodiments, a system includes two focusing traps combined in series, one inside of a GC oven and one in a separate oven to concentrate the SVOCs inside of the GC oven and concentrate the VOCs outside of the GC oven. Heating the VOC focusing trap and reversing the flow through both focusers allows splitless injection of compounds boiling from as low as −100° C. to as high as 600° C. in a single analysis, with a narrow injection bandwidth to optimize both sensitivity and the resolving power of the analyzer. | 2021-12-30 |
| 20210404996 | CHROMATOGRAPHIC DIMENSION SELECTION IN MULTIDIMENSIONAL LIQUID CHROMATOGRAPHY - A system capable of performing both single and multidimensional liquid chromatography includes a solvent delivery system, a sample injection system, a first dimension column path configured to perform a separation process in a first dimension, a second dimension column path configured to perform a separation process in a second dimension that is different than the first dimension, a valve system; and a sample injection system fluidically connected to the valve system. The valve system is configured to direct flow from a sample injection system to a first dimension column path when the valve system is in a first position, and to direct flow from the sample injection system to the second dimension column path without the flow path flowing through the first dimension column path in the chromatography system when the valve system is in a second position. | 2021-12-30 |
| 20210404997 | AUTOSAMPLER - A circulation device causes gas to circulate between a sample storage space and a temperature adjustment space through the first and second opening regions in a separating member. A temperature of gas flowing in the temperature adjustment space is adjusted by a heat exchanger, so that the temperature of gas surrounding a sample in the sample storage space is adjusted. The separating member further has first and second unit regions. The second opening region includes a first portion located in the first unit region and a second portion located in the second unit region. The shortest distance between the first portion and the first opening region is larger than the shortest distance between the second portion and the first opening region, and an aperture ratio of the first portion in the first unit region is larger than an aperture ratio of the second portion in the second unit region. | 2021-12-30 |
| 20210404998 | APPARATUS AND METHODS FOR MULTIDIMENSIONAL CHROMATOGRAPHY ANALYSIS - A multidimensional chromatographic assembly includes a chromatographic medium selector module, which receives a sample from an injector module and moves the sample through one of at least two chromatographic media of a chromatographic medium module using at least one eluent from at least one fluid moving module. At least a portion of the sample is re-circulated through the same or the second chromatographic medium using a multi-configuration fluid diverting module, which isolates a selected portion of the chromatographed eluent containing at least a portion of the sample in at least one fluid holding compartment and later moves the isolated portion through one of the chromatographic media in an iterative manner until all attributes of the isolated portion in question are analyzed. A detector module, which is located between the chromatographic medium selector module and the fluid diverting module, acquires data each time a portion of the sample passes through the detector module and provides data for a multidimensional chromatogram. The configurable portion (the rotor) of the fluid diverting module comprises movable flow-paths with two termini, which lie on a circular perimeter, concentric to the axis of rotation of the rotor, on the interfacial plane where the rotor meets the stationary portion of the fluid diverting module (the stator), and a connecting coplanar groove, spatial disposition of which is either concave or convex to the circular perimeter with only the termini intercepting the perimeter. The entire assembly is controlled by a controller, which receives data from the detector module and sends instructions to all modules during the multidimensional analysis with or without human intervention. | 2021-12-30 |
| 20210404999 | GAS CHROMATOGRAPH SYSTEM - The gas chromatograph system | 2021-12-30 |
| 20210405000 | GAS PHASE COMPONENT ANALYSIS DEVICE AND GAS PHASE COMPONENT ANALYSIS METHOD - A gas phase component analysis device and a gas phase component analysis method that can prevent degradation of the device due to an unnecessary component and can obtain excellent detection sensitivity are provided. | 2021-12-30 |
| 20210405001 | LIQUID ANALYZER SYSTEM WITH ON-LINE ANALYSIS OF SAMPLES - An analyzer system ( | 2021-12-30 |
| 20210405002 | Sample Measurement Device, Program, and Measurement Parameter Setting Assistance Device - A sample measurement device includes a measurement unit ( | 2021-12-30 |
| 20210405003 | CONVERSION OF LONG CELL DATA TO SHORT CELL EQUIVALENT - A method of converting longer path cell signal data to shorter path cell signal data comprising: obtaining a longer path absorbance signal tracing and a shorter path absorbance signal tracing for at least one analyte band under the same conditions; obtaining an approximate superimposable match between the longer path absorbance signal tracing and the shorter path absorbance signal tracing using an amplitude scaling factor and one or more parameters derived from a dispersion model that accounts for dispersion differences between a short cell and a long cell; and applying the dispersion model in reverse using the derived parameters to future longer path absorbance signal traces from the longer path cell signal data to generate the shorter path cell signal data. | 2021-12-30 |
| 20210405004 | INFORMATION PROCESSING APPARATUS, INFORMATION PROCESSING METHOD, AND PROGRAM - An information processing apparatus ( | 2021-12-30 |
| 20210405005 | METHODS AND SYSTEMS FOR DETECTING, ALERTING AND ELIMINATING LETHAL GASES - Methods, systems, and computer-readable mediums storing computer executable code for detecting and alerting of gases is provided. The method may include determining a parts per million of a specified gas. The method may also include comparing the determined parts per million to a pre-determined threshold. The method may include, when the parts per million meets or exceeds a threshold, generating a control signal. The method may also include transmitting the control signal to an alerting device to emit an alert to a user. The method may also include transmitting the control signal to a control device, wherein the control device performs a specified task. | 2021-12-30 |
| 20210405006 | ADAPTOR FOR USE WITH NON-CYLINDRICAL VAPOR PRODUCTS - A system for testing a vapor product with a mouthpiece that has a non-circular cross section includes an adaptor coupled to a neck portion of a filter pad holder. The adaptor includes a nose to receive the neck portion and an adaptor body coupled to the nose. An opening is defined by the adaptor body and the nose, the opening extending through the adaptor body and the nose and configured to receive the neck portion. A sealing member is configured to be received by the adaptor and the filter pad holder. The sealing member includes a sealing member nose configured to be received by the neck portion, and a sealing member body coupled to the sealing member nose and configured to be received by the opening. The sealing member body defines an orifice, the orifice extending through the sealing member body. | 2021-12-30 |
| 20210405007 | LOW-FLOW SIZE-SELECTIVE INLET FOR AIR QUALITY SENSORS AND AIR QUALITY SENSOR - An inlet or primary particle size fractionator for a direct-reading PM | 2021-12-30 |
| 20210405008 | MONITORING SYSTEM - A monitoring system ( | 2021-12-30 |
| 20210405009 | APPARATUS AND METHOD FOR MULTIMODAL SENSING AND MONITORING OF PERISHABLE COMMODITIES - Health of perishable commodities such as eatables deteriorate over time. State of art systems for health monitoring of perishable commodities rely on measurement of limited parameters and also fail to consider effect of environment on the health of the perishable commodities. Disclosed herein is an apparatus and method for multimodal sensing and monitoring of perishable commodities. The apparatus allows to change environment within a closed chamber in which the perishable commodity being monitored is kept, and in turn allows to generate health data in different environment settings. This data is used to generate a health model. Data collected in real-time are processed with the health model to establish a correlation with at least one image, wherein each of such images in the health model represents certain health state. Based on the established correlation, health of the perishable commodity is determined. | 2021-12-30 |
| 20210405010 | Method of monitoring at least one characteristic of a type of coffee - A method of monitoring at least one characteristic of a type of coffee from a plurality of reference characteristics associated with each type of coffee, each reference characteristic being associated with a respective reference signal, said method comprising the steps of:
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| 20210405011 | PHARMACEUTICAL FOR PREVENTING AND/OR TREATING STRESS LOAD-RELATED DISEASE - The present invention pertains to a medicine, said medicine comprising as an active ingredient a substance which suppresses the expression of at least one molecule selected from the group consisting of TMEM5, VSTM2L, C2CDD4D, VSTM2A, LY6G6C and ADRA2C or inhibits the activity thereof, for preventing and/or treating at least one disease or symptom selected from the group consisting of progressive multiple sclerosis, gastroenteritis, myocardial disorder and sudden death. Also, the present invention pertains to a method for screening a substance, which is capable of preventing and/or treating at least one disease or symptom selected from the group consisting of progressive multiple sclerosis, gastroenteritis, myocardial disorder and sudden death, with the use of the expression or activity of the aforesaid molecule as an index. | 2021-12-30 |
| 20210405012 | PORTABLE SYSTEM FOR ANALYSING MICROBIAL POPULATION IN A FLUID - A system and process may be used to test water samples to measure ATP and/or estimate a microbial population, for example using an adenosine triphosphate (ATP) based assay. The system includes a device that is use in combination with single-use or disposable cartridges. The cartridge receives the water sample and is pre-loaded with one or more reagents. The device receives the cartridge and contains physical, electronic and/or mechatronic devices that interact with cartridge. One or more actions such as metering, mixing and conveying are performed automatically by elements of the device and/or cartridge. A sensor in the device measures light produced in the cartridge from a reaction with ATP in the water sample. Optionally, the cartridge also contains a pre-loaded amount of ATP, which is used to provide an internal reference or calibration measurement. | 2021-12-30 |
| 20210405013 | MOBILE UNIT AND METHOD FOR CONTINUOUSLY MONITORING FLOWING COOLING WATER - The present invention provides a continuous mobile monitoring unit of a flow of cooling water comprising means to extract a flow of cooling water, means to analyze a plurality of parameters of the cooling water by means of diverse analytical techniques, generating results relating to each one of the parameters analyzed, and means to return the flow of cooling water to the cooling system ( | 2021-12-30 |
| 20210405014 | METHODS AND DEVICES CORRELATING WELL-LOGS TO CUTTINGS LITHOLOGIES FOR SYNTHETIC CORE GENERATION - An exploration method starts from cuttings associated with sampling intervals and well data for a well in a subsurface formation. The cuttings are prepared and analyzed to extract textural and chemical/mineralogical data for plural fragments in each sample that is made of the cuttings in one sampling interval. The method then includes matching lithotypes of rock defined according to the textural and chemical/mineralogical data for each fragment with segments of the well data in the corresponding sampling interval to obtain correspondences between the lithotypes and depth ranges. The correspondences between the lithotypes and the depth ranges may be used as constraints for seismic data inversion. | 2021-12-30 |
| 20210405015 | SOIL MOISTURE DOWNSCALING USING TOPOGRAPHY, SOIL, AND VEGETATION DATA - Systems and methods are disclosed to downscale the resolution of a coarse-resolution soil moisture data. Coarse-resolution soil moisture data may include data cells that each represent a geographic region having at least one dimension greater than or equal to 1 km. A plurality of fine-resolution supplemental soil moisture data may be received that includes at least one of soil data, vegetation data, topography data, and climate data. The fine-resolution supplemental soil moisture data comprising data cells that each represent a geographic region having at least one dimension less than or equal to 100 meters. The coarse-resolution soil moisture data may be downscaled to fine-resolution soil moisture data using the plurality of fine-resolution supplemental soil moisture data, the fine-resolution soil moisture data comprising data cells that each represent a geographic region having at least one dimension less than 100 meters. | 2021-12-30 |
| 20210405016 | System And Method For Measuring Mud Properties - A downhole tool may comprise a mandrel, wherein the mandrel is a structural support for the downhole tool; one or more arms, wherein the one or more arms are attached to the mandrel; and a pad, wherein the pad is connected to the one or more arms. The pad may comprise a material, where the material expands or contracts from an external electromagnetic field; an insulator, wherein the insulator is connected at a first end to the material; and an electrode, wherein the electrode is connected to the insulator. A method may comprise applying a time varying biasing voltage to a material, wherein the material exhibits mechanical strain; taking a first measurement and a second measurement with at least one operating frequency with an electrode; calculating a mud property based at least in part on the first measurement and the second measurement; and applying a mud effect removal algorithm to the mud property. | 2021-12-30 |
| 20210405017 | DETECTING AMINE-BASED INHIBITORS IN DRILLING FLUIDS - Described herein are methods to determine an amount of shale inhibitor in drilling fluids used in wellbore operations. In some cases, methods include receiving a sample of a drilling fluid, removing solids from the sample to produce a solids-free fluid, contacting the solids-free fluid with an anion to produce a precipitate in a test solution, and determining an amount of an amine-based shale inhibitor within the sample by measuring the amount of the precipitate in the test solution. | 2021-12-30 |
| 20210405018 | APPARATUS AND TEST METHOD FOR TREATMENT FLUID SELECTION - A crude oil displacement method includes partially filling a vessel with treatment fluid and positioning an oil-saturated sample within the treatment fluid. The method also includes adding a solvent system to the vessel above the treatment fluid. In addition, the method includes moving oil from the oil-saturated sample into the solvent system. The method also includes measuring one or more of R, G, B, L, a, b, L, C, H, H, S, B, reflectance, transmittance and wavelength of the displaced oil using a color device. In addition, the method includes determining the amount of displaced oil using the one or more of R, G, B, L, a, b, L, C, H, H, S, B, reflectance, transmittance and wavelength of the displaced oil. | 2021-12-30 |
| 20210405019 | OBTAINING INFORMATION FROM A BIOLOGICAL SAMPLE IN A FLOW CELL - Methods are used for obtaining, cataloguing, and/or storing data derived from a biological source using a flow cell body, electrodes, and an imaging assembly. The data may include DNA and/or RNA obtained from a biological source, such as from the cells of an organism. The methods may be used to obtain, catalog, and/or store data such as DNA or RNA sequence from a pathogen such as a virus and/or a bacteria, human health data over time, and immune system information from an individual. The data obtained using the disclosed methods may be used for a variety of different purposes, including the manufacture of vaccine compositions, and for restoring the immune system of an individual who has undergone an immune system depleting event. The methods may be used for storage of biological cells, which may be used for the screening of compounds, such as small molecules with potential for therapeutic indications. | 2021-12-30 |
| 20210405020 | Dual Pore - Control and Sensor Device - Two-pore devices and method for sequencing are described. A two-pore device can include first chamber, a second chamber, and a third chamber, wherein the first chamber is in communication with the second chamber through a first nanopore, and wherein the second chamber is in communication with the third chamber through a second nanopore. The device can also include sensing circuitry for measuring electrical signals associated with a target at a nanopore, and a control circuitry for controlling motion of the target at a nanopore. The device can include and/or switch between sensing and control modes for each of the first nanopore and the second nanopore. Sequencing methods can implement a two-pore device in relation to translocation of a target through one or more nanopores, switching between sensing and control modes as appropriate, and measuring aspects of the target using in sensing modes. | 2021-12-30 |
| 20210405021 | METHOD AND APPARATUS FOR PROVIDING DATA PROCESSING AND CONTROL IN A MEDICAL COMMUNICATION SYSTEM - Methods for data processing and control for a medical communication system are provided, including determining a sensitivity value for each sensor of a batch of in vivo analyte sensors; determining a sensitivity variation for each sensor of the batch; determining a mean sensitivity based on the sensitivity value determined for each sensor of the batch when it is determined that the determined sensitivity variation does not exceed a tolerance threshold level; associating a sensor code with each sensor of the batch of in vivo analyte sensors when the mean sensitivity is within a predetermined sensitivity range, wherein the sensor code associated with each sensor is based on a characteristic of the associated sensor; and storing the sensor code associated with at least one sensor of the batch configured to generate signals corresponding to monitored analyte level in a memory of a data processing device associated with the sensor. | 2021-12-30 |
| 20210405022 | SYSTEMS AND METHODS FOR PARTICLE ANALYSIS - The present disclosure provides systems and methods for sorting a cell. The system may comprise a flow channel configured to transport a cell through the channel. The system may comprise an imaging device configured to capture an image of the cell from a plurality of different angles as the cell is transported through the flow channel. The system may comprise a processor configured to analyze the image using a deep learning algorithm to enable sorting of the cell. | 2021-12-30 |
| 20210405023 | METHOD FOR DIAGNOSING CLOSTRIDIOIDES DIFFICILE INFECTION - A method for diagnosing a subject with Clostridioides | 2021-12-30 |
| 20210405024 | COMPOSITIONS COMPRISING STABILIZED OXYGEN AND METHODS OF FORMING THE SAME - Disclosed herein are compositions comprising oxygen, a sugar or sugar alcohol, and an amino acid, wherein the amino acid is present in an amount sufficient to stabilize the oxygen. Also provided are aqueous diagnostic quality controls or calibration reagents and methods of stabilizing oxygen in a liquid solution. | 2021-12-30 |
| 20210405025 | IDENTIFYING COMPOUNDS FOR TREATING CANCER AND USE THEREOF - Provided herein is a method for identifying compounds that inhibit cell growth or have cytotoxic activity against cancer cells, such as hematological cancer cells or ovarian cancer cells, in a subject. Further provided is a method for identifying one or more compounds that sensitize refractory cancer cells from a subject. Also provided are compositions and methods for treating cancer, including refractory cancer, such as refractory acute myeloid leukemia (AML) or ovarian cancer. | 2021-12-30 |
| 20210405026 | METHOD FOR EVALUATING THE PRESENCE OF A VIRAL RESERVOIR, AND EVALUATING THE EFFICACY OF A DRUG AGAINST SAID RESERVOIR - A method for the evaluation of the efficacy of a drug aiming to eradicate a cellular reservoir of mammalian cells infected with a mammalian immunodeficiency virus, the method including: a) quantifying, the presence of lymphocyte cells expressing a CD32 differentiation marker on their surface; and b) concluding that the drug is efficient to eradicate the cellular reservoir of mammalian cells infected with the mammalian immunodeficiency virus when lymphocyte cells expressing a CD32a differentiation marker are absent. | 2021-12-30 |
| 20210405027 | IN VITRO NEPHROTOXICITY SCREENING ASSAY - The invention relates to methods for predicting the in vivo nephrotoxicity of a drug substance, in particular a nucleic acid molecule such as a siRNA or an antisense oligonucleotide using an in vitro cell based assay measuring the levels of extracellular EGF as toxicity biomarker, potentially in combination with other biomarkers like ATP and KIM-1. | 2021-12-30 |
| 20210405028 | DETECTION AND MODIFICATION OF GUT MICROBIAL POPULATION - Methods and systems for evaluating heath/disease state of an individual are provided herein. In particular, the disclosure provides methods for measuring levels of one or more metabolites of interest in an individual and using these measurements to assess the individual's health. The disclosure also provides systems for carrying out the disclosed methods. For example, the disclosed systems may include a metabolite level evaluation module to determine the individual's heath based on the metabolite levels measured. | 2021-12-30 |
| 20210405029 | COMPOUNDS INHIBITING NEF-CALNEXIN INTERACTION - The invention relates to compounds and methods for restoring or preserving cholesterol efflux in a cell infected with Human Immunodeficiency Virus (HIV) by preventing or decreasing an interaction between Negative Regulatory Factor (Nef) protein and Calnexin protein, and methods for screening for such compounds. | 2021-12-30 |
| 20210405030 | MEANS AND METHODS FOR DETERMINING METABOLIC ADAPTATION - The present invention relates to a method of determining a metabolic adaptation of a living entity of interest to a first set of environmental conditions and to a second set of environmental conditions comprising (a) determining with a first substrate concentration at least two activities of at least one enzyme comprised in a specimen of said living entity maintained under said first set of environmental conditions and at least two activities of said at least one enzyme comprised in a specimen of said living entity maintained under said second set of environmental conditions, wherein said activities are determined at two non-identical points in time t | 2021-12-30 |
| 20210405031 | SMALL ANIMAL MODELS FOR IN VIVO TESTING OF POLYOMAVIRUS THERAPEUTICS - Animal models that are permissive for human polyomaviruses and their uses for the screening of candidate agents are described. | 2021-12-30 |
| 20210405032 | FUNCTIONAL VALIDATION OF DONOR IMMUNE-REGULATORY CELLS - The invention provides methods for the validation of donor immune-regulatory cells. The validation method includes a combination of assays to determine the capability of immune-regulatory cells to immune-regulate adaptive and innate immune system components. | 2021-12-30 |
| 20210405033 | ANALYTE DETECTION AND METHODS THEREFOR - Disclosed are methods and systems for analyte detection in a sample and more particularly, a biological sample. Methods and systems particularly relate to differentiating and/or identifying cell types in biological samples, such as blood samples, by adding antibodies specific to predetermined CD antigens. Other methods and systems relate to controlling the dynamic range of an assay for analyte detection. | 2021-12-30 |
| 20210405034 | SYNTHETIC BI-EPITOPE COMPOUND - A bi-epitope compound of formula (I): | 2021-12-30 |
| 20210405035 | MULTIFUNCTIONAL POLYMERIC MICROSPHERE/MICROPARTICLE CELL BIOREACTOR SYSTEM AND SORTING PROCESS - A cell selection and sorting process includes attaching cells of a target cell type to a first set of polymeric beads, washing the chamber through a first filter having a first pore size less than the first bead diameter to retain the first set of polymeric beads and greater than a cell diameter to remove unattached cells, releasing the cells of the target cell type from the first set of polymeric beads, and collecting the cells of the target cell type. A cell modification process includes modifying cells of the target cell type in the chamber. A cell modification system includes a cell modification chamber with entry ports and outlet ports, filters with predetermined pore sized selectably located on the outlet ports, and sets of polymeric beads with predetermined diameters being selected such that the sets of polymeric beads are separable by the filters. | 2021-12-30 |
| 20210405036 | METHOD OF FABRICATING SUBSTRATE FOR ANALYSIS, SUBSTRATE FOR ANALYSIS, AND ANALYSIS UNIT - A method of fabricating a substrate for analysis fixes antibodies that specifically react with specific antigens included in detection target substances to the substrate for analysis. The method subjects the substrate for analysis to immersion treatment with a predetermined treatment solution so as to form antibody aggregations in which the antibodies are aggregated at boundary regions between recesses and convex portions on the substrate for analysis. The method causes the antigens and the antibodies to react with each other so as to capture the detection target substances on the substrate for analysis by the antibody aggregations. | 2021-12-30 |
| 20210405037 | Electrochemical Antibody-Based Biosensor - Methods and sensors using antibody-based electrochemical detection of analytes including small molecules make use of the specific recognition of analyte-bound antibody by the complement system protein C1q. The antibody is immobilized to an electrode to which a potential is applied and the C1q protein is linked to a redox-active molecule, such that binding of C1q to the analyte-bound antibody brings the redox-active molecule in contact with the electrode, whereupon the analyte is detected by an increase in current. | 2021-12-30 |
| 20210405038 | DEVELOPMENT AND PARAMETER ASSESSMENT FOR VERTICALLY ALIGNED PLATINUM WIRE APTASENSOR ARRAYS FOR IMPEDIMETRIC DETECTION OF CARDIAC BIOMARKERS - The invention relates to ex-situ biosensors that impedimetrically detect cardiac biomarkers of interest in a bodily fluid sample derived from a patient. The biosensors include a multi-array of vertically aligned platinum wires having immobilized thereon an aptamer that is selected to specifically and selectively bind to the cardiac markers of interest. The biosensors are contacted with a portion of the bodily fluid sample, and the aptamer binds to the cardiac markers of interest in the bodily fluid sample. As a result, an electrochemical impedance signal is generated and therefore, a change in electrochemical impedance is indicative of the presence of the cardiac markers of interest in the bodily fluid sample. The biosensors are point-of-care, on-demand devices that can be used in a medical environment, as well as in domestic settings. | 2021-12-30 |
| 20210405039 | NANOPORE BIOSENSORS FOR DETECTION OF PROTEINS AND NUCLEIC ACIDS - Described herein are nanopore biosensors based on a modified cytolysin protein. The nanopore biosensors accommodate macromolecules including proteins and nucleic acids, and may additionally comprise ligands with selective binding properties. | 2021-12-30 |
| 20210405040 | Cleaning Device and Chemiluminescence Detector - The present disclosure relates to a cleaning device and a chemiluminescence detector. A cleaning device is provided with a cup inlet station and a cup outlet station, wherein the cleaning device comprises a pedestal, a plurality of magnetic adsorption components, a turntable arranged on the pedestal, and a primary cleaning mechanism arranged on the pedestal, wherein each of the plurality of magnetic adsorption components comprises a plurality of magnets; magnetic adsorption heights of a plurality of magnets of the first magnetic adsorption component are equal and are recorded as A; magnetic adsorption heights of a plurality of magnets of the middle magnetic adsorption component are equal and are recorded as B, and B>A. | 2021-12-30 |
| 20210405041 | PARTICLE-BASED SENSORS AND METHODS USING PARTICLE-BASED SENSORS FOR DETECTION OF ANALYTES - The disclosure relates to particle-based assays for the detection of analytes. Using various combinations of particular technologies, including gold nanorods, silver nanoparticles, gold/silver nanoshells, gold/silver nanocages and nanobubble detection, enhanced detection limits can be achieved across a large range of analytes. | 2021-12-30 |
| 20210405042 | ONE-POT BIOSENSOR AND IMMUNOASSAY METHOD USING THE SAME - Disclosed are a one-pot biosensor and an immunoassay method using the same. The one-pot biosensor includes a photocatalyst substrate deposited with metal nanoparticles; and a reaction pad which is disposed on an upper surface of the photocatalyst substrate and includes a first binding material-fluorescent material complex specifically binding to a molecule to be detected, and the immunoassay method using the same. The one-pot biosensor may detect a target by once solution injection and has a size enough to be portable. Accordingly, since the one-pot biosensor can detect the target by only once solution injection without a washing step, because of a sensor platform capable of being easily used by an individual other than a diagnostic expert, it is predicted to be positioned as a means capable of confirming the health condition of the individual without seeing the doctor, such as a pregnancy diagnostic kit which has been currently commercialized. | 2021-12-30 |
| 20210405043 | TWO-SIDED FLOW-THROUGH IMMUNOASSAY - A two-sided flow-through immunoassay testing device is provided. The device comprises a well having therein a plurality of orifices, the plurality of orifices serving to channel biologic material deposited into the well onto different immunoassay pods, wherein the immunoassay pods may contain immunoassay test layers stacked to create an immunoassay test. The device further includes a results window. Inside the device, and between the window and the pods, there are open sections below each pod to allow a user to view the results of the tests as presented on the reaction layers of the pods through the window. | 2021-12-30 |
| 20210405044 | SANDWICH-TYPE ASSAYS USING DECREASING SIGNAL PORTIONS OF DOSE RESPONSE CURVE TO MEASURE ANALYTES, INCLUDING ANALYTES AT HIGH CONCENTRATION - Sandwich-type lateral flow assay devices, systems, and methods described herein measure concentration of an analyte of interest in a sample, and can determine the precise concentration of the analyte when it is present at high concentrations. A signal of maximum intensity is generated when the concentration of analyte of interest in a sample is zero. For low concentrations of analyte, the lateral flow assays described herein generate signals that are the same as or substantially equivalent to the maximum intensity signal. High concentrations of the analyte of interest generate signals that are less than the maximum intensity signal. Lateral flow assays of the present disclosure solve drawbacks associated with the hook effect of sandwich-type lateral flow assays by eliminating the phase of the dose response curve where signals are increasing. | 2021-12-30 |
| 20210405045 | DIAGNOSTIC TEST DEVICE WITH IMPROVED USE AND VISUAL DETECTION OF AN ANALOG TEST RESULT - The present disclosure relates to diagnostic test devices that provide improved communication to a user of one or both of proper functioning of the test device and an analog test result that is provided by the test device. The diagnostic test devices particularly can include one or more sensors effective to indicate application of a sufficient volume of a test fluid and/or can include one or more light sources positioned to illuminate an analog test result for improved visibility and understanding of the analog test result. | 2021-12-30 |
| 20210405046 | DIAGNOSIS OF SCLERODERMA - Described herein are methods of diagnosing systemic sclerosis (SSc) involving the detection of anti-vinculin antibodies. Also described herein are methods of selecting treatment of subjects diagnosed with systemic sclerosis (SSc), and methods of treating systemic sclerosis (SSc). | 2021-12-30 |
| 20210405047 | ANTI-CARBAMYLATED PROTEIN ANTIBODIES AND THE RISK FOR ARTHRITIS - Antibodies against citrullinated protein antigens (ACPA) have shown their relevance for the diagnosis and possibly pathogenesis in arthritis. Described are means and methods for determining antibodies against homocitrulline-containing proteins or carbamylated proteins/peptides (anti-CarP) for the classification of individuals suffering from, or at risk of suffering from, arthritis. | 2021-12-30 |
| 20210405048 | Diagnosing Sepsis or Bacteremia by Detecting Peptidoglycan Associated Lipoprotein (PAL) in Urine - A method, device and kit for detecting sepsis or bacteremia in a patient includes detecting peptidoglycan associated lipoprotein (Pal) from Gram-negative bacteria in the urine of the patient is disclosed. | 2021-12-30 |
| 20210405049 | METHODS AND MATERIALS FOR ASSESSING IMMUNE SYSTEM PROFILES - This document provides methods and materials involved in assessing immune system profiles. For example, methods and materials for performing flow cytometry to determine the number of CD4 | 2021-12-30 |
| 20210405050 | SENSOR - The present invention provides an isolated binding reagent that specifically binds to a recombinant Cocoa Swollen Shoot Virus (CSSV) coat protein antigen having at least 80% sequence identity to the amino acid sequence of SEQ ID NO: 2 or 4 and/or at least 80% sequence identity to the nucleotide sequence of SEQ ID NO: 1 or 3. A porous membrane based sensor for detecting CSSV comprising a recombinant CSSV coat protein antigen and a method for detecting CSSV using the sensor are also provided. A competitive ELISA for detecting viral infections in plants is also provided. | 2021-12-30 |
| 20210405051 | METHOD AND APPARATUS FOR RAPID DETECTION OF SARS-COV-2 - A method and apparatus for comfortably, rapidly, and inexpensively collecting a sample from one or more test subjects and analyzing it, singly or pooled with other samples, for presence of SARS-CoV-2. Saliva, nasal drainage, or other body fluids may be collected from one or more test subjects and examined by means of fluorimetry. Mass rapid screening for SARS-CoV-2 is a valuable public health tool to reduce the transmission of COVID-19 while permitting business activity to resume. | 2021-12-30 |
| 20210405052 | FLUID ACTUATION OF INSTRUMENTS THROUGH A STERILE BARRIER - A robotic surgical system includes a fluid drive system and a surgical instrument removably positioned in operative engagement with the drive system. A sterile barrier covers non-sterile portions of the surgical system. Features of the sterile barrier are used to transfer motion output from the fluid drive system to the instrument for actuation of the instrument. | 2021-12-30 |
| 20210405053 | METHOD FOR PROVIDING DIAGNOSTIC INFORMATION FOR BILIARY TRACT CANCER AND APPARATUS FOR DIAGNOSING BILIARY TRACT CANCER - The present disclosure relates to a method for providing diagnostic information for biliary tract cancer and an apparatus for diagnosing biliary tract cancer. According to an aspect of the present disclosure, there is provided a method for providing diagnostic information for biliary tract cancer including obtaining biological samples; measuring concentration of a marker for predicting biliary tract cancer in the biological samples; and providing diagnostic information for biliary tract cancer using the measured concentration of the marker, where the marker includes Nudifloramide. | 2021-12-30 |
| 20210405054 | METHODS FOR DETECTING OVARIAN CANCER - The present disclosure is related to the field of ovarian cancer diagnostics. It introduces novel biomarkers that can be used to detect presence of ovarian cancer and to provide a prognosis of the disease. | 2021-12-30 |
| 20210405055 | SINGLE CELL GENOMIC PROFILING OF CIRCULATING TUMOR CELLS (CTCS) IN METASTATIC DISEASE TO CHARACTERIZE DISEASE HETEROGENEITY - The disclosure provides a method of detecting heterogeneity of disease in a cancer patient comprising (a) performing a direct analysis comprising immunofluorescent staining and morphological characteristization of nucleated cells in a blood sample obtained from the patient to identify and enumerate circulating tumor cells (CTC); (b) isolating the CTCs from the sample; (c) individually characterizing genomic parameters to generate a genomic profile for each of the CTCs, and (c) determining heterogeneity of disease in the cancer patient based on the profile. In some embodiments, the cancer is prostate cancer. In some embodiments, the prostate cancer is hormone refractory. | 2021-12-30 |
| 20210405056 | METHODS FOR DETECTING MUTANT P53 FUNCTION - Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The methods described herein can detect and quantify the ability of a therapeutic agent to reconform a mutant conformation of mutant p53 to a conformation that possesses physiological activity of wild type p53. The disclosed method can be used as a companion diagnostic to detect and quantify the efficacy of a therapeutic agent in reducing the progression of cancers that contain a p53 mutation. | 2021-12-30 |
| 20210405057 | METHODS AND COMPOSITIONS FOR DETERMINING THE COMPOSITION OF A TUMOR MICROENVIRONMENT - The disclosure relates to the field of immuno-oncology. More specifically, the disclosure relates to methods and compositions for performing single-cell phenotypic and functional analysis of immune and cancer cells disposed within a tumor microenvironment. The methods and compositions permit the determination of whether a subject with a solid tumor is likely to respond to a particular immunomodulator, and also permit the treatment of a solid tumor in a subject by facilitating the selection of an immunomodulator suitable for treating the solid tumor in the subject. | 2021-12-30 |
| 20210405058 | MACROMOLECULE ANALYSIS EMPLOYING NUCLEIC ACID ENCODING - A method for analyzing macromolecules, including peptides, polypeptides, and proteins, employing nucleic acid encoding is disclosed. | 2021-12-30 |
| 20210405059 | BIOMARKERS FOR EARLY DETERMINATION OF A CRITICAL OR LIFE THREATENING RESPONSE TO ILLNESS AND/OR TREATMENT RESPONSE - The invention relates to the use of novel biomarkers and biomarker combinations having utility in the early determination of an individual's critical and/or life threatening response to illness and/or in predicting outcome of said illness. The measurement of expression levels of the products of the biomarkers and combinations of biomarkers of the invention have utility in making the determination of an individual's critical and/or life threatening response to illness. In some embodiments, the biomarker and biomarker combinations are agnostic and are independent of the pre-identification and/or determination of the cause or nature of the illness. In some embodiments, the biomarkers and biomarker combinations can be utilized to select treatment and/or monitor the effectiveness of treatment interventions for an individual who has a critical illness. | 2021-12-30 |
| 20210405060 | METHODS AND REAGENTS FOR ANALYZING PROTEIN-PROTEIN INTERFACES - The present disclosure provides methods and reagents useful for analyzing protein-protein interfaces such as interfaces between a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein. In some embodiments, the target and/or presenter proteins are intracellular proteins. In some embodiments, the target and/or presenter proteins are mammalian proteins. | 2021-12-30 |
| 20210405061 | METHOD FOR MEASURING AB PEPTIDE - Disclosed is a method for measuring an Aβ peptide in a blood sample in vitro, comprising: measuring the Aβ peptide by an immunoassay using an antibody set comprising a capture antibody and a detection antibody that specifically bind to the Aβ peptide, wherein the capture antibody is an antibody that binds to an epitope comprising an N-terminal residue of the Aβ peptide, the detection antibody is an antibody that binds to an epitope different from the epitope to which the capture antibody binds, and the Aβ peptide is at least one selected from the group consisting of Aβ40 or Aβ42. | 2021-12-30 |
| 20210405062 | METHOD FOR EVALUATING DATA FROM MASS SPECTROMETRY, MASS SPECTROMETRY METHOD, AND MALDI-TOF MASS SPECTROMETER - The invention relates to a method to evaluate mass spectrometry data for the analysis of peptides from biological samples, particularly MALDI-TOF mass spectrometry data, comprising the steps of: providing expected mass defects; determining measured mass defects, i.e. the mass defects resulting from the mass spectrometry data; and comparing the measured mass defects with the expected mass defects. | 2021-12-30 |
| 20210405063 | ASSAY DETECTION METHODS FOR VCAM-1 AND CALPROTECTIN - Assay methods for detecting the presence or amount of VCAM-1 or calprotectin in a sample using fluorescence resonance energy transfer (FRET). | 2021-12-30 |
| 20210405064 | BI-FUNCTIONAL ARGININE-GLYCINE-ASPARTIC ACID (RGD) PEPTIDES AND METHODS TO PROMOTE ANGIOGENESIS - The present invention provides an in vitro method for identifying a compound that promotes endothelial cell adhesion, endothelial cell spreading, endothelial cell migration and/or endothelial cell proliferation for the manufacture of a diagnostic or therapeutic agent. The present invention further provides the identified compounds and pharmaceutical compositions, and assays and kits for identifying a compound or using a compound that promotes endothelial cell adhesion, endothelial cell spreading, endothelial cell migration and/or endothelial cell proliferation and is useful for bioprinting. | 2021-12-30 |
| 20210405065 | METHOD FOR INCREASING CELL SUSCEPTIBILITY TO COMPLEMENT- MEDIATED LYSIS - A method is provided for increasing the sensitivity of the complement-dependent cellular cytoxicity analysis that establishes whether a potential transplant recipient patient expresses donor organ-reactive antibodies that would reduce or prevent acceptance of the donor organ by a recipient. At least one gene encoding a complement inhibitor is inactivated in cells derived from a candidate transplant organ. Such modified cells, because they no longer produce at least one complement inhibitor, when placed in a serum sample from a potential transplant recipient, do not reduce the effective activity of serum complement. A lower level of recipient patient serum antibodies becomes effective in inducing detectable lysis of the donor cells. | 2021-12-30 |
| 20210405066 | SYSTEMS AND METHODS FOR IDENTIFYING AND TREATING NEURODEGENERATIVE DISEASE - Various embodiments provide a multi-faceted algorithm tool would impact the burden of disease through improvements to clinical practice and by hastening the development of novel therapeutic treatments. In addition, the multi-faceted algorithm tool provides evidence of target engagement in clinical trials and accelerates progress towards disease modification. | 2021-12-30 |
| 20210405067 | COMPOSITION FOR DIAGNOSING MILD COGNITIVE IMPAIRMENT CONTAINING TonEBP ANTIBODY AS AN EFFECTIVE COMPONENT - A method for diagnosing mild cognitive impairment according to an embodiment of the present disclosure includes obtaining a sample from a subject to be diagnosed, and measuring a level of tonicity-responsible enhancer binding protein (TonEBP) in the sample by using TonEBP antibody to determine if the measured level of the TonEBP is above a predetermined level. The measuring may further includes measuring a level of lipocalin-2 (LCN2) in the sample by using LCN2 antibody to determine if the measured level of the LCN2 is above a predetermined level. | 2021-12-30 |
| 20210405068 | METHOD FOR MEASURING A PEPTIDE - Disclosed is a method for measuring an Aβ peptide, comprising: mixing a blood sample comprising an Aβ peptide and an antibody that specifically binds to the Aβ peptide to form a complex of the Aβ peptide and the antibody; releasing the AP peptide from the complex with a basic solution comprising an organic solvent; and measuring the released Aβ peptide by mass spectrometry. | 2021-12-30 |
| 20210405069 | Alpha-Synuclein Detection Assay and Method for Diagnosing Alpha-Synucleinopathies - A method of detecting the presence of alpha-synuclein aggregation in a biological sample is provided whereby a biological sample is mixed with a reaction sample comprising a population of beads, a fluorophore adapted to bind to protein aggregates and to increase fluorescence when bound to protein aggregates, and alpha-synuclein or a fragment or variant thereof to form a reaction mixture, the reaction mixture is illuminated and at the same time incubated with intermittent agitation cycles, wherein a significant increase in the fluorescence of the reaction mixture during incubation is indicative of the presence of aggregates of alpha-synuclein in the biological sample. Method of diagnosing alpha-synucleinopathies such as Parkinson's disease or Dementia with Lewy Bodies. | 2021-12-30 |
| 20210405070 | Pro-ADM for Prognosis of Trauma-Related Complications in Polytrauma Patients - The invention relates to a method for the diagnosis, prognosis, prediction, risk assessment and/or risk stratification of a subsequent trauma-related complication in a polytrauma patient, comprising providing a sample of said patient, wherein the sample is isolated from the patient after the polytrauma, determining a level of pro ADM or fragment(s) thereof in said sample, wherein said level of pro ADM or fragment(s) thereof correlates with the likelihood of a subsequent trauma-related complication | 2021-12-30 |
| 20210405071 | BIOMARKERS FOR PREDICTING IMMINENT OVULATION OR REPRODUCTIVE COMPETENCE IN MARES - Broodmare imminence of ovulation and reproductive competence may be determined by collecting blood, serum or plasma samples from a mare over two or more days in such mare's estrous cycle; obtaining a set of concentration measurements of one or more peptide hormones of the TGF-β superfamily in such samples over such two or more days; detecting an onset of a change in the relative magnitude or slope of successive concentration measurements of such one or more peptide hormones during such cycle; and coordinating live cover or artificial insemination of such mare to occur no later than three days after such onset. The disclosed method may be performed using an associated system that measures, processes and stores the measurements. The system may detect and optionally provide notification of the onset of such change. | 2021-12-30 |
