52nd week of 2018 patent applcation highlights part 12 |
Patent application number | Title | Published |
20180369408 | CYCLODEXTRIN AND ANTIBODY-DRUG CONJUGATE FORMULATIONS - Disclosed are formulations, including both liquid and lyophilized formulations, comprising a benzodiazepine antibody-drug conjugate (ADC) and a cyclodextrin. Also disclosed are methods of purifying mixtures comprising benzodiazepine antibody-drug conjugates and process drug-related impurities. | 2018-12-27 |
20180369409 | TUMOR-SPECIFIC PAYLOAD DELIVERY AND IMMUNE ACTIVATION USING A HUMAN ANTIBODY TARGETING A HIGHLY SPECIFIC TUMOR CELL SURFACE ANTIGEN - This invention provides antibodies directed against a highly specific and previously unrecognized marker for cancerous cells. In certain embodiments an isolated antibody or fragment thereof that specifically binds human placentally expressed ALPP and/or ALPPL2, but not ALPL and ALPI that are expressed outside the placenta is provided as well as immunoconjugates comprising such antibodies. | 2018-12-27 |
20180369410 | DENDRIMER-EXOSOME HYBRID NANOPARTICLES AS A DELIVERY PLATFORM - Described herein are hybrid nanoparticles that are exosomes loaded with one or more nanoparticle dendrimers. Also included are pharmaceutical compositions including the hybrid nanoparticles and methods of making the hybrid nanoparticles. Also described is a method of treating a human subject by administering to the human subject the above-described hybrid nanoparticles. | 2018-12-27 |
20180369411 | MULTI-SPECIFIC BINDING CONJUGATE, RELATED PHARMACEUTICAL COMPOSITIONS AND USE - The present invention relates to a multi-specific binding conjugate, a related composition and use. The binding conjugate comprises binding moieties for two or more different receptors, co-receptors, antigens or cellular markers which moieties are coupled by a nanomaterial. The multi-specific binding conjugate can be used to modulate an immune response, treat or prevent a disease or condition (e.g., a cancer, autoimmune disease, pathogen infection or inflammatory disease). | 2018-12-27 |
20180369412 | Compositions and Methods for Correction of Heritable Ocular Disease - A nucleic acid trans-splicing molecule is provided that can replace an exon in a targeted mammalian ocular gene carrying a defect or mutation causing an ocular disease with an exon having the naturally-occurring sequence without the defect or mutation. A method of treating an ocular disease, e.g., Stargardt's Disease, caused by a defect or mutation in a target gene, e.g., ABCA4 comprising: administering to the ocular cells of a subject having an ocular disease a composition comprising a recombinant AAV comprising a nucleic acid trans-splicing molecule as described above. | 2018-12-27 |
20180369413 | MESSENGER RNA THERAPY FOR THE TREATMENT OF FRIEDREICH'S ATAXIA - The present invention provides methods and compositions of treating Friedreich's ataxia (FRDA) based on administering an mRNA encoding a frataxin protein. | 2018-12-27 |
20180369414 | MATERIALS AND METHODS FOR DELIVERING NUCLEIC ACIDS TO COCHLEAR AND VESTIBULAR CELLS - Provided herein are materials and methods for efficiently delivering nucleic acids to cochlear and vestibular cells. | 2018-12-27 |
20180369415 | METHODS AND COMPOSITIONS FOR TREATMENT OF OCULAR DISORDERS AND BLINDING DISEASES - Codon optimized nucleic acid sequences for the long form and short form of RdCVF are provided, as well as recombinant viral vectors, such as AAV, expression cassettes, proviral plasmids or other plasmids containing the codon optimized sequences. Recombinant vectors are provided that express the codon optimized RdCVFL and RdCVF individually, or express two copies of a codon optimized RdCVF or RdCVFL nucleic acid sequence, or both RdCVFL and RdCVF in a single vector or virus. Compositions containing these codon optimized sequences are useful in methods for treating, retarding or halting certain blinding diseases resulting from the absence or inappropriate expression of RdCVF and RdCVFL. | 2018-12-27 |
20180369416 | TARGETED GENE DELIVERY TO NON-PHAGOCYTIC MAMMALIAN CELLS VIA BACTERIALLY DERIVED INTACT MINICELLS - A method of targeting bacterially-derived, intact minicells to specific, non-phagocytic mammalian cells employs bispecific ligands to deliver nucleic acids efficiently to the mammalian cells. Bispecific ligands, comprising (i) a first arm that carries specificity for a bacterially-derived minicell surface structure and (ii) a second arm that carries specificity for a non-phagocytic mammalian cell surface receptor are useful for targeting minicells to specific, non-phagocytic mammalian cells and causing endocytosis of minicells by non-phagocytic cells. | 2018-12-27 |
20180369417 | ANTITUMOR IMMUNITY ENHANCING COMPOSITION CONTAINING ADENOVIRUS SIMULTANEOUSLY EXPRESSING IL-12 AND SHVEGF - The present invention relates to an oncolytic adenovirus simultaneously expressing interleukin-12 and shVEGF, and an antitumor immunity enhancing composition and an anticancer effect promoting composition each containing the same. The present inventors verified that the simultaneous occurrence of VEGF inhibition and IL-12 expression induced the recovery of an immune function and the promotion of an anticancer effect in an immunological mouse melanoma or kidney cancer model. Especially, the applicability of a gene carrier simultaneously expressing IL-2 and shVEGF in the cancer gene therapy was first established by disclosing that the increased anticancer effect is involved in an increase in anticancer immunity, an increase in TH 1 cytokine, and the prevention of tumor induced thymic atrophy. | 2018-12-27 |
20180369418 | COMPOSITION FOR TREATMENT OF CRIGLER-NAJJAR SYNDROME - The invention provides a polynucleotide sequence (e.g., a gene, e.g., DNA or RNA) encoding UGT1A1 (e.g., expressing human UGT1A1). The invention further provides a vector, such as an adeno-associated virus (AAV) vector (e.g., AAV8) having a vector genome including inverted terminal repeat sequences and a UGT1A1 coding sequence operably linked to one or more expression control sequences (e.g., expression control sequences including a liver-specific promoter). Also provided are compositions containing these AAV vectors and methods of treating Crigler-Nijjar syndrome type I, Crigler-Nijjar syndrome type II, and Gilbert syndrome. | 2018-12-27 |
20180369419 | COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF AGENTS - The disclosure features amino lipids and compositions involving the same. Nanoparticle compositions include an amino lipid as well as additional lipids such as phospholipids, structural lipids, PEG lipids, or a combination thereof. Nanoparticle compositions further including therapeutic and/or prophylactic agents such as RNA are useful in the delivery of therapeutic and/or prophylactic agents to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression. | 2018-12-27 |
20180369420 | COMPOSITIONS AND METHODS FOR THE EXPRESSION OF CRISPR GUIDE RNAS USING THE H1 PROMOTER - The presently disclosed subject matter provides compositions and methods for the expression of CRISPR guide RNAs using the H1 promoter. In particular, compositions and methods are provided for the use of the H1 promoter to express CRISPR guide RNA (gRNA) with altered specificity of the 5′ nucleotide, as well as use of the H1 promoter sequence as a bidirectional promoter to express Cas9 nuclease and the gRNA simultaneously. Compositions and methods are also provided for the expression and regulation of gRNA expression in vivo through the use of RNA ribozymes and regulatable aptazymes. | 2018-12-27 |
20180369421 | METHOD FOR REDUCING THE PLACEBO EFFECT IN CLINICAL TRIALS - Methods for lowering the placebo effect or inducing an Acebo effect in a clinical trial are disclosed. The methods are directed to including a group of subjects in a clinical trial wherein the additional group is administered a substance that has at least one known effect which can worsen the disease or disorder that is being studied in the clinical trial, or can cause one of the primary or secondary subsymptoms of the disease or disorder that is being studied in the clinical trial, or can cause a related or unrelated effect of the disease or disorder that is being studied in the clinical trial (an Acebo). | 2018-12-27 |
20180369422 | NANOPARTICLES FOR CANCER DETECTION - Disclosed herein, inter alia, are methods for detecting cancer using nanoparticles. | 2018-12-27 |
20180369423 | ANIMAL MODELS FOR NONALCOHOLIC FATTY LIVER DISEASE - The present disclosure provides non-human animal models of non-alcoholic fatty liver disease (NAFLD). Also provided are methods for producing the non-human animal models and uses of the non-human animal models to screen and evaluate agents for treating or preventing NAFLD. | 2018-12-27 |
20180369424 | LIBRARY OF PH RESPONSIVE POLYMERS AND NANOPROBES THEREOF - The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug. | 2018-12-27 |
20180369425 | LINKED AND OTHER pH-TRIGGERED COMPOUNDS - Provided herein are, inter alia, pH-triggered compounds and compositions comprising one or more peptides that are capable of inserting into a lipid bilayer below a certain pH. Treatment, imaging, diagnostic, and other uses of such compounds and compositions are also provided. | 2018-12-27 |
20180369426 | COMPOSITIONS COMPRISING FLUORESCENT DYES ASSOCIATED WITH VIRAL COMPONENTS FOR NERVE IMAGING - Disclosed herein is a composition for imaging nerve cells. The composition includes a fluorescent dye; and a viral component including a neurotropic herpes varicellae unable to replicate in nerve cells, a viral protein of a neurotropic herpes varicellae unable to replicate in nerve cells, a capsid of a neurotropic herpes varicellae unable to replicate in nerve cells, or a combination thereof. The fluorescent dye is bound to the viral component to form a dye/viral component complex that is capable of penetrating nerve cells. | 2018-12-27 |
20180369427 | NON-NUTRITIVE SWEETENERS AND POLYOLS AS IMAGING AGENTS - The present disclosure relates to magnetic resonance imaging (MRI) methods comprising (i) obtaining a baseline chemical exchange saturation transfer (CEST) MRI image of a patient, (ii) administering an effective amount of a non-nutritive sweetener to the patient, and (iii) obtaining one or more test CEST MRI image of the patient subsequent to the administering step (ii); wherein the step (i) and (iii) acquisition parameters are substantially the same. The non-nutritive sweetener may include a natural or artificial sugar alcohol, polyol, or combinations or derivatives thereof. | 2018-12-27 |
20180369428 | RADIOACTIVE PROBE FOR DETECTING HYDROGEN SULFIDE - Provided is a probe for detecting in vivo hydrogen sulfide, specifically, a probe for detecting hydrogen sulfide including a complex compound into which a radioactive isotope Cu is introduced. According to specific embodiments of the present disclosure, as a result of real-time observing animal models, in which hydrogen sulfide involved in various diseases is generated in a large quantity, through optical and nuclear medicine imaging, the probe for detecting hydrogen sulfide according to the present disclosure may selectively bind with hydrogen sulfide to provide images of a site where hydrogen sulfide has abnormally increased in a cell or a tissue, thereby detecting a disease in an unexpected site without affecting the anatomical properties of the body. In addition, the probe for detecting hydrogen sulfide quickly reacts with hydrogen sulfide, thereby solving the existing problem of waiting a predetermined time for testing after an imaging agent is injected. Accordingly, the probe may be effectively used as a means for diagnosing diseases, such as a composition for imaging, an imaging method, etc. | 2018-12-27 |
20180369429 | RADIOLABELLED mGluR2/3 PET LIGANDS - The present invention relates to novel, radiolabeled mGluR2/3 ligands, selective versus other mGlu receptors which are useful for imaging and quantifying the metabotropic glutamate receptor mGlu2 and 3 in tissues, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, to processes for preparing such compounds and compositions, to the use of such compounds and compositions for imaging a tissue, cells or a mammal, in vitro or in vivo and to precursors of said compounds. | 2018-12-27 |
20180369430 | METHOD OF DIAGNOSING AND/OR MONITORING THERAPY OF ATHEROSCLEROSIS - The present invention is directed to novel non-invasive diagnostic took to dispose numerous disease states and/or conditions. The presets invention, represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these disease states. The novel imaging probe is capable of detecting infected cells, as well tissue. The methods described herein are able to diagnose, treat and/or monitor the therapy of numerous diseases and conditions including atherosclerosis, atherothrombosis, cerebral vascular disease, cerebral ischemia, cerebral infarct and meningitis as well as pneumonitis, pericarditis, multiple sclerosis, lupus erythematosus and pancreatitis, among others. | 2018-12-27 |
20180369431 | Ex vivo labeled myeloid derived suppressor cells (MDSC) for cancer imaging - The present invention relates to myeloid derived suppressor cells (MDSCs) and using these cells in conjunction with nuclear medicine imaging methods to image cancer tumors. The MDSC cells are separated from blood and either radiolabeled with nuclear medicine agents or pretargeting agents and reinjected in patient. The cells preferentially concentrate in tumors allowing imaging of cancer tumors. The imaging technique can be used to image tumors for diagnosis and/or assessment of treatment response for cancer patients undergoing cancer treatments. | 2018-12-27 |
20180369432 | Disinfecting Methods and Apparatus - According to one implementation an assembly is provided that includes an end emitting optical that is configured to end emit bacterial disinfecting light. A portion of the length of the end emitting optical fiber resides in a lumen of a body. The body has an internal disinfecting target area. The end emitted bacterial disinfecting light is configured to impinge on one or more surfaces disposed on or in the body, the one or more surfaces being configured to alter the trajectory of the bacterial disinfecting light so that the bacterial disinfecting light is directed toward the disinfecting target area via a designated disinfecting light pathway. | 2018-12-27 |
20180369433 | SELF-ADJUSTING DAMPER BASED LINEAR ALIGNMENT SYSTEM - A steam sterilizer having a door movable relative to an opening between a first open position and a second closed position. A plurality of spaced-apart roller assemblies are aligned along edges of the door to align the door relative to the opening as the door moves between the open and closed position. Each of the roller assemblies are comprised of a cylindrical roller having an outer annual recess extending along the periphery thereof. The recess is dimensioned to receive a lateral edge of the door. The roller is mounted on a shaft and is movable against a biasing force axially along the axis of the shaft. | 2018-12-27 |
20180369434 | Disinfection Systems and Methods for Operating a Light System - In an example, a method of operating a UV light source for a vehicle includes measuring an amount of power on a commodity power feeder, determining when the measured amount of power is greater than a threshold amount of power and, responsively, actuating a switch to a first state in which the switch decouples the UV light source from the power on the commodity power feeder. The method also includes determining when the measured amount of power is less than the threshold amount of power and responsively actuating the switch to a second state in which the switch couples the UV light source to the power on the commodity power feeder. The method also includes, while the switch is in the second state, activating the UV light source, using the power from the commodity power feeder, to emit UV light in the vehicle. | 2018-12-27 |
20180369435 | Disinfecting System with Performance Monitoring - A system includes multiple devices configured to emit and detect germicidal radiation. Each of the multiple devices operates in emitting mode when connected to a drive source in a forward bias configuration and operates in detecting mode when disconnected from the drive source or when connected to the drive source in a reverse bias configuration. Cycling circuitry generates a sequence of control signals that control switching circuitry to change the connections of the devices to the drive source in a cycle in which one or more of the multiple devices are switched to detecting mode and senses radiation emitted by one or more of the multiple devices simultaneously operating in emitting mode. Each device operating in detecting mode generates a signal in response to the sensed radiation. Detection circuitry detects signals of the devices operating in detecting mode and generates a detection output in response to the detected signals. | 2018-12-27 |
20180369436 | METHOD AND APPARATUS FOR STERILIZING SLEEVE - Provided are a method and an apparatus for sterilizing a sleeve that can shorten a sterilization process for a paper container sleeve and ensure a sterilization effect. | 2018-12-27 |
20180369437 | INFECTION CONTROL METHOD AND SYSTEM - A method for controlling infections in a facility such as a hospital or foodservice establishment is provided. The method comprises tagging assets, monitoring asset location and pathogen contamination for each asset over time, analyzing data sets to identify which assets are the critical control points for pathogen transfer, and coating a residual self-sanitizing coating composition on each asset identified as a critical control point. The infection control method shuts down pathogen transfer routes by mitigating or eliminating pathogen growth on the critical control points. | 2018-12-27 |
20180369438 | INFECTION CONTROL APPARATUS - An apparatus is provided for controlling hospital acquired infections by targeting critical control points for pathogen transfer. An infection control apparatus comprises an asset tagging unit; a spraying unit; a power supply unit; optionally a DNA/RNA sequencing unit; and a computing unit comprising a non-transitory computer-readable medium encoded with program instructions for controlling the asset tagging unit and the spraying unit to perform a method of infection control in the facility. In general, the apparatus is used to identify which assets are critical control points for pathogen transfer and to treat those assets with a residual self-sanitizing coating. | 2018-12-27 |
20180369439 | Systems and Methods for Operating a Light System - In an example, a light control system includes a power converter and a UV light source. The power converter includes an input for receiving an input power from a power source during a time interval, a power buffer for storing power using the input power received at the input during a first portion of the time interval, and an output for outputting a supply power during a second portion of the time interval. The supply power includes a combination of power from (i) the input power received at the input during the second portion of the time interval and (ii) the power stored in the power buffer during the first portion of the time interval. The UV light source is configured to, using the supply power during the second portion of the time interval, emit UV light at an intensity providing a target level of antimicrobial efficacy. | 2018-12-27 |
20180369440 | CLEANLINESS INDICATION SYSTEMS AND METHODS - A cleanliness indication system and a method that indicate that a surface of a component is clean. The cleanliness indication system and method include a photoluminescent indicator that is configured to be on the surface of the component. The photoluminescent indicator is configured to be exposed to ultraviolet (UV) light during a UV light sanitizing cycle. The photoluminescent indicator emits light due to exposure to the UV light. The photoluminescent indicator indicates that the surface of the component is clean by emitting the light due to exposure to the UV light. | 2018-12-27 |
20180369441 | HIGH-EFFICIENCY SYSTEM AND DEVICE IN MASS TRANSFER - The invention relates to a method, device and system, by means of which the temperature of liquid can be controlled, via solid surfaces which are humidified and supplied with an airflow, as well as acquiring moisture via being in contact with a water source, which water source, as well as said surfaces, tend to cool down, and in doing so, same and any equipment subject to the same laws and/or phenomena will lose efficiency due to the change in temperature of the liquids involved in the humidification process. | 2018-12-27 |
20180369442 | DIGITAL AROMA DISPERSION SYSTEM AND DEVICES - The present invention is directed to a digital aroma system that provides a scented air on demand to various devices in various forms and user held devices including: remote controls and mobile computing devices. Dry fragrance infused substrates are contained in fragrance cartridges that are removably mounted in a cassette that is connected to a manifold that has airway passages that are connected to fans or pumps that are controlled by a computer processor. In response to a fragrance control signal, the processor can selectively direct scented air having a specified fragrance to a system user. | 2018-12-27 |
20180369443 | System and Method for Dispensing Material - A fluid dispensing method, the method comprising steps of: providing a drop on demand apparatus comprising a plurality of nozzles in fluid communication with a fluid reservoir; selecting a subset of the plurality; dispensing fluid via the selected subset of the plurality; pausing all dispensing of fluid; selecting a second subset of the plurality; dispensing fluid via the second selected subset of the plurality. | 2018-12-27 |
20180369444 | SHAPE MEMORY SPACER FABRIC COMPOSITE - The invention provides a shape memory spacer fabric composite, being a spacer fabric coated with a shape memory polymer layer, wherein the spacer fabric comprises a first outer layer, a second outer layer and an intermediate spacing layer connecting the first outer layer and the second outer layer; the shape memory polymer layer is made from at least one block or random copolymer selected from the group consisting of the following: polyesters, polyurethanes, polyamides, polyols; the copolymer has at least one phase transition temperature in a range of 40˜80° C. | 2018-12-27 |
20180369445 | Injectable, Biodegradable Bone Cements And Methods Of Making And Using Same - Compositions of, methods of making, and methods of using alkaline earth phosphate bone cements are disclosed. | 2018-12-27 |
20180369446 | CURABLE SILICONE (PRE-) POLYMER COMPOSITION COMPRISING A CONTRAST AGENT - The invention relates to a kit of parts suitable for preparing a cured biocompatible silicone polymer material including an X-ray contrast agent, the kit comprising two or more containers containing a fluid component, which components—when mixed—form a fluid curable biocompatible polymer composition, which upon curing forms the cured biocompatible silicone polymer material, wherein a first container contains a fluid component A, which component A comprises a curable silicone (pre-)polymer and a curing agent and which component A is essentially free of curing catalyst and metallic X-ray contrast agent particles, and | 2018-12-27 |
20180369447 | Compositions With Reactive Ingredients, And Wound Dressings, Apparatuses, And Methods - Wound dressings and wound inserts comprising substantially dry reactive agents, methods of forming wound inserts comprising dry reactive agents, and wound-treatment methods. | 2018-12-27 |
20180369448 | Biodegradable Poly(Ester Amide) Elastomers and Uses Therefor - Provided herein are biodegradable poly(ester amide) elastomers, methods of making the elastomers, and methods of using the elastomers, for example for tissue engineering. The elastomers can be used for preparation of tissue prostheses, such as a heart valve leaflet, a heart valve, cartilage, myocardium, blood vessels, smooth muscle, skeletal muscle, or other tissues. Also provided herein are semiquantitative FTIR methods for determining structure of a poly(ester amide) elastomer. | 2018-12-27 |
20180369449 | PREPARATION OF ACELLULAR CARTILAGE GRAFT AND USES THEREOF - Disclosed herein is a method of producing acellular cartilage grafts. The method includes steps of, subjecting a cartilage matrix derived from an animal to alkaline, disinfection and decelluarization treatments. The thus produced cartilage graft is devoid of any cellular matters, while maintaining the porosity and integrity of collagen fibers therein, thus is suitable as a xenograft for host cells to grown thereon. Also disclosed herein is a method for treating osteochondral disease of a subject, in which the present acellular cartilage graft is applied to a lesion site of the subject. | 2018-12-27 |
20180369450 | METHOD FOR PREPARING CELL GROWTH SCAFFOLD HAVING STRUCTURAL MEMORY PROPERTIES - Disclosed is a method for preparing a cell growth scaffold having a structural memory feature, comprising a step of preparing a micro-fibrous or flocculent acellular tissue matrix material; a step of preparing an acidification-treated hydrogel-like acellular tissue matrix particles; proportionally mixing the micro-fibrous or flocculent acellular tissue matrix material with the acidification-treated hydrogel-like acellular tissue matrix particles, followed by injection-molding, freezing treatment, radiation treatment, and ultimately preparing a porous cell growth scaffold that can be stored at room temperature. The prepared cell growth scaffold is a porous cell growth scaffold that has no chemical crosslinking, and has a biological activity, a stable three-dimensional structure and a structural memory feature. The cell growth scaffold has an excellent biocompatibility and complete biodegradability, and supports the growth of cells and the growth of tissues and organs in vitro and in vivo, thereby being suitable for repair of human soft tissue traumas and defects. | 2018-12-27 |
20180369451 | ROTATING DEVICE AND METHOD FOR CONTINUOUS FABRICATION OF LONG BIOLOGICAL TUBES - Disclosed are bioprinters for rapidly fabricating biological tubes comprising extruding a bio-ink filament onto a rotating mandrel. Also disclosed are methods of rapidly fabricating biological tubes comprising extruding a bio-ink filament onto a rotating mandrel, maturing the deposited bio-ink filament, and removing the biological tube from the mandrel. Also disclosed are methods of fabricating a multilayered biological tube. Also disclosed are engineered biological tubes prepared using the disclosed methods. | 2018-12-27 |
20180369452 | COMBINATION COMPOSITIONS - Combination compositions comprising self-assembling peptides and payload agents, and methods of making and using such compositions, are described. | 2018-12-27 |
20180369453 | POLYMERIC BASED AND SURFACE TREATED METALLIC HYBRID MATERIALS AND FABRICATION METHODS THEREOF - Novel hybrid materials and fabrication methods thereof are provided. The novel hybrid materials can include a biodegradable polymer and a biodegradable metallic material. The hybrid material can also include a coupling agent between the biodegradable metallic material and the biodegradable polymer. A method of fabricating a hybrid material can include performing a surface treatment process on the biodegradable metallic material, and then either performing a solvent formation method or a thermal formation method. | 2018-12-27 |
20180369454 | HIGH STRENGTH POROUS MATERIALS INCORPORATING WATER SOLUBLE POLYMERS - High strength biomedical materials and processes for making the same are disclosed. Included in the disclosure are nanoporous hydrophilic solids that can be extruded with a high aspect ratio to make high strength medical catheters and other devices with lubricious and biocompatible surfaces. Polymers may be entrapped in pores of materials to provide a durable modification of the materials. | 2018-12-27 |
20180369455 | METHODS AND MATERIALS FOR TREATING BLOOD VESSELS - This document provides methods and materials for treating a mammal (e.g., a human) having one or more stenotic blood vessels. For example, amnion coated balloons that can be used in balloon angioplasty are provided. | 2018-12-27 |
20180369456 | APPARATUS AND METHOD FOR WOUND VOLUME MEASUREMENT - A method and apparatus for measuring a volume of a wound are described, the method comprising the steps of: applying a dressing over a wound, the volume of which is to be measured, the dressing including at least a sealing drape over the wound so as to create a sealed wound cavity; creating a vacuum in said wound cavity by vacuum pump means so as to produce a predetermined vacuum in the wound cavity; measuring a volume of air extracted from said wound cavity in producing said predetermined vacuum; and, calculating a volume of said wound. | 2018-12-27 |
20180369457 | VACUUM ASSISTED IRRIGATION PUMP - Embodiments of the present invention relate to the field of pressurized fluid delivery devices for use in medical procedures. In particular, a fluid delivery pump comprises at least one compressive member configured to apply a force to a fluid reservoir. The at least one compressive member is associated with a flexible envelope, such that the flexible envelope may move the compressive member. The flexible envelope may be substantially air-tight so that it may be pressurized. When a negative pressure is created inside the flexible envelope, the flexible envelope may change volume, applying a force to the at least one compressive member. The at least one compressive member may then apply a force to the fluid reservoir and the fluid is forced out of the reservoir. | 2018-12-27 |
20180369458 | Irrigated Catheter with Retrograde Flow - An irrigated ablation system with retrograde flow includes one or more medical devices (e.g., an ablation catheter and sheath) encompassing an irrigation lumen that terminates distally at an irrigation orifice and a drainage lumen that terminates distally at a drainage orifice. One or more pumps are coupled to the irrigation lumen and to the drainage lumen to deliver irrigant through the irrigation lumen and to extract fluid through the at least one drainage lumen. For example, a peristaltic pump can be used to simultaneously deliver irrigant through the irrigation lumen and to extract an equivalent volume of fluid through the drainage lumen. Alternatively, a feedback controller can be used to monitor parameters, such as impedance, pressure, ablation time, and/or irrigant volume, and control based thereon the rate at which the pump extracts fluid. | 2018-12-27 |
20180369459 | ACCESSORY FOR A NASAL MUCOUS ASPIRATOR, NASAL ASPIRATOR AND KIT - An accessory for a nasal mucus aspirator includes an accessory body suitable to be gripped and a terminal nozzle placed at a distal end of said accessory body and suitable to be at least partially inserted into a nostril of a user. In the accessory body, there are formed a compressed air inlet passage suitable to be fluidically connected to a compressed air source for receiving a flow of air at a positive pressure, said compressed air inlet passage defining a constriction so as to generate a Venturi effect, and an aspiration duct flowing into said constriction and fluidically connected to the terminal nozzle so as to generate a negative pressure due to the Venturi effect suitable to aspirate the mucus. | 2018-12-27 |
20180369460 | WOUND DRESSING SYSTEM - Device for the recovery of cell-free serum from whole blood, comprising a blood bag for the reception and the coagulation of the whole blood into a solid fraction and into a fluid containing a serum, wherein the blood bag has an outlet and a barrier in the area of the outlet which is suitable for retaining at least a major portion of the solid fraction and for the passage of said fluid, a filter module which is fluidically connected to the blood bag via the outlet, comprising an interior in which a semi-permeable membrane is arranged which subdivides the interior into a retentate space and a permeate space and allows the separation of the fluid into a serum as a permeate and into a retentate in which possible particulate components contained in the fluid remain, wherein the filter module has an inlet device for introducing the fluid into the retentate space and a permeate outlet for discharging the serum from the permeate space, and at least one receiving container for serum, comprising an inlet opening which is connected to the permeate outlet of the filter module via a connecting line. | 2018-12-27 |
20180369461 | FLUID VOLUME MEASUREMENT USING CANISTER RESONANCE FOR REDUCED PRESSURE THERAPY SYSTEMS - A wound fluid collection system includes a canister adapted to collect bodily fluids from a tissue site. The canister includes an acoustic transducer adapted and positioned to insonify a cavity within the canister, the cavity being defined by a wall of the canister and the bodily fluids collected within the canister. A resonant frequency may be calculated based on a resulting received signal from the insonification. The resonant frequency may indicate a volume of the cavity within the canister. The difference between a known volume of the canister and the calculated volume of the cavity provides the volume of bodily fluid collected in the canister. | 2018-12-27 |
20180369462 | SYSTEM FOR PROVIDING WOUND DRESSING PORT AND ASSOCIATED WOUND DRESSING - A wound dressing for use in a vacuum wound therapy treatment includes a backing layer for positioning over a wound to define a reservoir in which a reduced pressure may be maintained over the wound. A portal member affixed to the backing layer provides a connection to a reduced pressure source through an opening in an ambient surface. A primary port extends between the opening and a primary aperture in a reservoir surface to providing fluid communication between the reservoir and the reduced pressure source. At least one supplemental port establishes fluid communication between the primary port and a supplemental aperture in the reservoir surface that is distinct and substantially spaced from the primary aperture. | 2018-12-27 |
20180369463 | BREAST PUMP - A breast pump according to the present invention includes a variable pressure generating unit, the variable pressure generating unit including a power driving unit including a stepping motor that is capable of rotating both normally and in reverse, and a negative pressure forming unit that creates a negative pressure state periodically by causing an elastic body to deform in accordance with a cycle period formed by the power driving unit, wherein the negative pressure forming unit is coupled to the expressing unit, and the stepping motor is capable of modifying an amplitude of the cycle period and the cycle period during negative pressure formation as desired. Hence, a suction pressure and a pressure increase/decrease cycle can both be set as desired, and moreover, a breast pump that uses electric power can be constructed compactly. | 2018-12-27 |
20180369464 | BREAST PUMP, METHOD AND COMPUTER PROGRAM - The present invention relates to a breast pump ( | 2018-12-27 |
20180369465 | EXTRACORPOREAL CIRCULATION MANAGEMENT DEVICE WITH HEARTBEAT SYNCHRONIZATON - An extracorporeal circulation management device pumps blood in synchronization with heartbeats of a patient based on measurements of blood flow. Maximum and minimum blood flow measurement samples are compared with upper and lower threshold values to identify candidate timing for a systolic phase and diastolic phase of the heartbeat. During pulsatile pumping of the blood using the candidate timing, differences in the pulsatile flow measurements are determined. Based on the size of the difference, a final correction may be made to identification of the systolic and diastolic phases, and the corrected phase information is used to start and stop the motor unit. | 2018-12-27 |
20180369466 | HEART PUMP WITH IMPELLER AXIAL POSITION CONTROL - A heart pump including a housing defining a cavity including at least one inlet and at least one outlet, an impeller provided within the cavity, the impeller including vanes for urging fluid from the inlet to the outlet upon rotation of the impeller, a drive that rotates the impeller within the cavity, a magnetic bearing including at least one bearing coil that controls an axial position of the impeller within the cavity, a sensor that senses an axial position of the impeller within the cavity and a controller. The controller includes an electronic processing device that, in response to a change in axial hydraulic forces on the impeller determines an axial position of the impeller within the cavity, determines a reference power in accordance with the determined axial position and controls the magnetic bearing to cause the impeller to move until a bearing power indicator indicative of the power used by the magnetic bearing reaches the reference power. | 2018-12-27 |
20180369467 | BLOOD PUMP - The present invention relates to a blood pump. The blood pump according to the present invention includes: a housing including an inlet, through which blood flows, at an upper part of the housing and an outlet, through which the blood is discharged, along an edge of the housing; an impeller part, which is rotatable and disposed inside the housing, including a plurality of blades on the surface thereof so as to move the blood flowing in through the inlet toward the outlet by using a centrifugal force; a rotary shaft member disposed to penetrate the center part of the impeller part so as to support the impeller part to be rotatable which moves the blood to the lower part thereof; and a magnetic body disposed on the impeller part for rotating the impeller part in a predetermined direction according to a change in a magnetic field outside the housing. | 2018-12-27 |
20180369468 | BLOOD PUMP CONTROL SYSTEM AND METHOD FOR CONTROLLING A BLOOD PUMP - Methods are provided for controlling the speed of a pump based on a valve state index and/or for deriving a valve state from time-series signal representing a pressure difference or a flow rate. The methods may be employed in blood pump systems or in blood pump control systems. | 2018-12-27 |
20180369469 | IMPLANTABLE PUMP SYSTEM HAVING A RECTANGULAR MEMBRANE - An implantable pump system is provided, including an implantable blood pump suitable for use as a partial support assist device, the system further including an extracorporeal battery and a controller coupled to the implantable pump, and a programmer selectively periodically coupled to the controller to configure and adjust operating parameters of the implantable pump. The implantable pump includes a flexible membrane coupled to an electromagnetic actuator including a magnetic assembly and electromagnetic assembly, so that when the electromagnetic assembly is energized, the electromagnetic assembly causes wavelike undulations to propagate along the flexible membrane to propel blood through the implantable pump. The controller may be programmed by a programmer to operate at frequencies and duty cycles that mimic physiologic flow rates and pulsatility while operating in an efficient manner that avoids thrombus formation, hemolysis and/or platelet activation. | 2018-12-27 |
20180369470 | TREATMENT FLUID PREPARATION SYSTEM - A system for purifying incoming fluid is modular and includes a heat exchanger module, an evaporator-condenser module and a compressor. The system components are arranged in a stacked configuration to facilitate gravitational flow of the purified fluid such that the purified fluid drains passively for collection. A system for preparation of ready-to-use treatment fluid includes the modular fluid purification system, a preparation station and a coupling device. The components are configured to be retained in a portable carrier that is manually operable for improved access to and mobility of the components. A coupling device can connect the flow channels of several components and can be used in preparing ready-to-use dialysate. A system prepares a receptacle and a ready-to-use treatment fluid in the receptacle. | 2018-12-27 |
20180369471 | DIALYSIS DEVICE - The invention relates to a dialysis device having an extracorporeal blood system, a dialyzing fluid system, a dialyzer and a control unit, wherein the dialysis device has a heating mechanism for heating the blood in the extracorporeal blood system before entry into the dialyzer or in the dialyzer as well as a cooling mechanism for cooling the blood in the extracorporeal blood system after exiting the dialyzer and wherein the control unit is configured such that the blood is heated before entry into the dialyzer or in the dialyzer to a dialysis temperature which is above the body temperature of the patient and is cooled back to the body temperature of the patient after exiting the dialyzer. | 2018-12-27 |
20180369472 | HEAT EXCHANGER TUBE FOR A HEAT EXCHANGER OF AN OXYGENATOR - The invention relates to a heat exchanger tube ( | 2018-12-27 |
20180369473 | Filtration Module - Provided is a filtration module for separating plasma from blood comprising a feeder channel lid, a feeder channel defined by a feeder channel laminating layer having a thickness of less than 5 mil, a filter element in fluid communication with the feeder channel and having a pore size of less than 2 microns and low surface area, and a filtrate take-off port having a dead volume of less than 10 μL. Also provided are methods for filtering a blood sample comprising supplying the blood sample to a feeder channel of a filtration module and drawing the blood sample over a filter element of the filtration module in a single pass process configuration to provide a retentate and a plasma filtrate. | 2018-12-27 |
20180369474 | EMERGENCY STOP FOR A SYSTEM AND A METHOD FOR ANAL AND/OR STOMAL IRRIGATION - A system for anal and/or stomal irrigation comprises a reservoir ( | 2018-12-27 |
20180369475 | High Flow Rate Dual Reservoir Port System - Devices and methods for obtaining high flow rates in a port catheter system, and devices and methods for using a high flow rate port catheter system are disclosed. In one embodiment, a reservoir is dedicated for aspiration and a separate reservoir is dedicated for infusion. Fluid flow channels associated with aspiration are larger than the fluid flow channels associated with infusion. The catheter connected to the port can have an offset tip configuration. Methods for accessing the port are also disclosed. | 2018-12-27 |
20180369476 | INFUSION PUMP LATCH MECHANISM AND ASSOCIATED FREE-FLOW PROTECTION DEVICE - An infusion pump apparatus includes a length of resilient tubing removably loadable in an infusion pump having a housing, a pumping mechanism, and a pump door. A latch member is pivotally mounted to the pump door and cooperates with a latch pin fixed on pump housing. A free-flow protection device is biased to pinch the tubing closed to stop fluid flow. The latch member has a first range of pivotal motion in a latching direction for causing the latch member to engage with the latch pin to secure the door in a closed position and a second range of pivotal motion in the latching direction for causing the latch member to actuate the free-flow protection device to unpinch the tubing and allow flow. The latch member pivots through at least a portion of the first range of pivotal motion before beginning to pivot through the second range of pivotal motion. | 2018-12-27 |
20180369477 | SYSTEMS AND METHODS FOR INCORPORATING PATIENT PRESSURE INTO MEDICAL FLUID DELIVERY - A medical fluid delivery machine includes a pump interface having an actuation area for delivering positive or negative pressure to a medical fluid handling device; a pressure sensor positioned to measure pressure within the actuation area; a valve positioned to selectively vent the actuation area to atmosphere; and a control unit in signal communication with the pressure sensor and control communication with the valve, the control unit performing a sequence during pumping, wherein (i) application of positive pressure or negative pressure to the actuation area is stopped, the valve is switched to vent the actuation area to atmosphere, then switched to close the actuation area to atmosphere, and at least one pressure signal reading is taken via the pressure sensor, and (ii) a determination is made whether positive pressure or negative pressure to the chamber should be resumed based on the at least one pressure signal reading. | 2018-12-27 |
20180369478 | MEDICAL INFUSION PUMPS AND SYSTEMS - A medical infusion pump for delivering a medicament to a patient. The pump includes a user interface to display a choice of nominal medicament delivery rates. The user interface enables a practitioner to select one of the displayed nominal medicament delivery rates. It further enables the practitioner to enter a numerical multiplier factor, thereby creating a nominal delivery rate. It further enables the practitioner to create a custom alphanumeric string that the practitioner associates with a patient characteristic, enter a numeric value relating to the patient characteristic, and determine an actual delivery rate by modifying the selected nominal medicament delivery rate based on the numeric value relating to the patient characteristic. The pump mechanism is then controlled to deliver medicament from a reservoir to a patient at the actual delivery rate. | 2018-12-27 |
20180369479 | Artificial Pancreas Integrated CGM Architectures and Designs - A system for managing a patient's glucose level includes a glucose sensor to generate and store data signals for measurements of the patient's glucose level made by the glucose sensor; an insulin pump; and sensor electronics operatively coupled to the glucose sensor, the sensor electronics comprising a memory storing one or more predetermined characteristics associated with the sensor electronics; and a computing device in electronic communication with the sensor electronics. The computing device comprises a processor configured to operate the sensor electronics to (i) receive the generated data signals, (ii) obtain the one or more predetermined sensor characteristics from the memory and (iii) execute a closed-loop algorithm to provide insulin delivery instructions to an insulin pump by at least using the data signals and predetermined characteristics. | 2018-12-27 |
20180369480 | INJECTION DEVICE FOR INJECTING DOSED AMOUNTS OF A LIQUID THERAPEUTIC AGENT - The invention relates to an injection device for injecting dosed amounts of a liquid therapeutic agent, with a receiving device for the therapeutic agent, an applicator device for transferring the therapeutic agent to an application site, a dosing device for transferring the therapeutic agent from the receiving device to the applicator device, a trigger device for activating the dosing device, and a detection device for detecting the applied amount of the therapeutic agent. A sensor arrangement is provided which comprises at least one identification device, which identifies whether the therapeutic agent has reached the application site or a site different than the application site. | 2018-12-27 |
20180369481 | AUTO INJECTOR WITH TEMPERATURE CONTROL - Disclosed is an auto injector and a method for administering a medicament. The auto injector comprising: a housing; a cartridge receiver; a drive module coupled to move a plunger rod configured to move a first stopper; a temperature sensor configured to provide a temperature signal indicative of the temperature of the medicament in the cartridge; a processing unit configured to: receive the temperature signal; control the drive module to move the plunger rod from a first plunger rod position to a mix plunger rod position wherein the movement from the first plunger rod position to the mix plunger rod position is based on the temperature signal. | 2018-12-27 |
20180369482 | AUTO INJECTOR WITH ADAPTABLE AIR-SHOT MECHANISM - Disclosed is an auto injector for administering a medicament. The auto injector comprising: a housing; a cartridge receiver configured to receive a cartridge assembly comprising a cartridge ( | 2018-12-27 |
20180369483 | AUTO INJECTOR WITH CHARGER SAFETY - An auto injector is disclosed comprising: a housing, a cartridge receiver, and an ejector member. The cartridge receiver is configured to receive a cartridge containing the medicament. The auto injector further comprises a blocking member coupled to an ejector member. The blocking member is configured to move between a blocking position wherein a connector opening is blocked and a non-blocking position wherein the connector opening is not blocked. | 2018-12-27 |
20180369484 | ADMINISTRATION APPARATUS DESIGN SYSTEM, ADMINISTRATION SYSTEM, ADMINISTRATION APPARATUS DESIGN METHOD, ADMINISTRATION APPARATUS DESIGN PROGRAM, AND MEDICAL APPARATUS DESIGN SYSTEM - Provided is a system for calculating design specifications of an administration apparatus which administers an administration object substance to an object region using a high-energy substance as a driving source. An object administration apparatus to be an object of calculation of the design specifications is specified and substance information related to a prescribed administration object substance to be administered in the object administration apparatus is acquired. Region information related to a prescribed object region is acquired, and distribution information related to a distribution state of the prescribed administration object substance is acquired. In addition, based on the respective pieces of acquired information, design specification information related to a configuration of the object administration apparatus including energy information related to a high-energy substance to be used to administer the prescribed administration object substance is calculated. Accordingly, convenience of the administration apparatus is improved. | 2018-12-27 |
20180369485 | Carpule/Cartridge and Syringe Holder Device and System - A device configured to securely hold syringes, used carpules/capsules, and unused carpules/capsules is described. The device is equipped with a first syringe holder and a second syringe holder, each disposed at differing angles with respect to a base of the device. The device is also equipped with multiple carpule/cartridge holders, each bored into the device. The entirety of the device is preferably metallic, lending to its capacity to be autoclaved for ideal sterilization before use. The device facilitates one-handed closing or capping of syringes, helping to ensure the safety of the patient and the administrator. It is envisioned that the device be used to contain liquid anesthetics to be administered to a patient. The placement of the carpule/cartridge holders enables the dentist or other dental staff to readily keep track of how much anesthetic has been applied, helping to prevent error or injury. And for documentation, to keep track of dosages used. Up to nine disposable syringes, to keep track of the quantity and type of medication injected. | 2018-12-27 |
20180369486 | NEEDLELESS INJECTION DEVICE WITH A CURVED MEMBRANE - A needleless injection device is provided that includes a body forming a housing, a gas generator, a tubular reservoir that contains an active ingredient, and a T-shaped elastically deformable membrane having a tubular portion. The reservoir extends axially in the housing from an upper end to a lower end and the tubular portion is configured to extend and lie axially in the reservoir under an effect of a pressure generated by the gas generator. An injection nozzle is arranged at the lower end of the reservoir. The tubular portion is funnel shaped and includes at least an upper segment that decreases along an axial elongation direction of the member and a lower segment that increases along the axial elongation direction. The axial length of the upper segment is greater than that of the lower segment. | 2018-12-27 |
20180369487 | SYRINGE ATTACHMENT DEVICE AND METHODS - A syringe adapter having a syringe holder and an actuator are disclosed. The syringe holder may include a fixed portion that may receive a barrel of a syringe and an adjustable portion adjustably positioned relative to the fixed portion, where the adjustable portion may receive a plunger of the syringe. To facilitate aspirating fluid to and/or dispensing fluid from the syringe, the actuator may be selectively actuated with one or more digits or a palm of a user's hand to adjust a position of the adjustable portion. The selective actuation of the actuator may be performed with one or more digits of the user while two or more other digits are engaging a portion of the adapter adjacent a dispensing end of the syringe. The adapter may include a gear system translating movement of the actuator to movement of the adjustable portion of the syringe holder. | 2018-12-27 |
20180369488 | Communication Device for Transmitting Information from a Medicament Delivery Device - A communication device arranged for transmitting information from a medicament delivery device is presented. The communication device includes at least one rotation detection arrangement, the at least one rotation detection arrangement being configured to detect a rotation of at least one physical part of the medicament delivery device. The communication device also includes at least one determination unit configured to determine information related to a medicament delivery performed by the medicament delivery device. The communication device further includes at least one activation unit configured to activate the at least one determination unit based on the detected rotation. Also, the communication device includes at least one transmission unit configured to provide a wireless transmission of the information to an external receiving device. | 2018-12-27 |
20180369489 | MEDICAL SYRINGE, GASKET TO BE USED FOR SYRINGE, AND GASKET PRODUCTION METHOD - A laminated gasket ( | 2018-12-27 |
20180369490 | SENSOR DEVICE REMOVABLY ATTACHABLE TO A DRUG DELIVERY DEVICE - A sensor device removably attachable to a drug delivery device includes a sensing arrangement arranged within the sensor device and
| 2018-12-27 |
20180369491 | MEDICAL DELIVERY DEVICE - Medical delivery device ( | 2018-12-27 |
20180369492 | MEDICAL DELIVERY DEVICE - A medical delivery device ( | 2018-12-27 |
20180369493 | MEDICAL DELIVERY DEVICE - A medical delivery device ( | 2018-12-27 |
20180369494 | ROTARY SENSOR ASSEMBLY WITH LOW-POWER FEATURE - A rotary sensor assembly, comprising a first sensor part with a plurality of position sensor segments, and a second sensor part with a grounded contact in contact with a position sensor segment. For a current incremental rotational position a contact is in contact with an un-powered current-position sensor segment, with the neighbour segments being in a powered state. When the contact is rotated to a powered next-position position sensor segment, the next-position sensor segment becomes a new current-position sensor segment. Electronic circuitry is adapted to detect that the new current-position sensor segment is grounded and that the first and second sensor parts thereby have been rotated one increment relative to each other, and subsequently change the state of the former current-position sensor segment from un-powered to powered and the state of the new current-position sensor segment from powered to un-powered. | 2018-12-27 |
20180369495 | Needle Shield Remover and a Medicament Delivery Device Comprising the Needle Shield Remover - A needle shield remover for assembly with a cap of a medicament delivery device, wherein the needle shield remover comprises a longitudinally elongated tubular body ( | 2018-12-27 |
20180369496 | Pen Needle Attachment Mechanisms - User-friendly attachment mechanisms for pen needles provide improved handling and ease of use, including locking installation and removal features and sensory feedback when a needle-bearing hub is seated on a pen. | 2018-12-27 |
20180369497 | MEDICAMENT DELIVERY DEVICE - The present disclosure relates to a medicament delivery device including a cartridge holder to which an injection needle holder can be fixed, the injection needle holder holding an injection needle having a proximal end and a distal end, the proximal end being protected by an inner injection needle cap detachably connected to the injection needle holder, the cartridge holder being mounted in a housing and configured to receive a cartridge of medicament, a cap assembly detachably connected to the housing, and
| 2018-12-27 |
20180369498 | MEDICAMENT INJECTION DEVICE WITH SPRING-ASSISTED PROTECTIVE NEEDLE CAP - A medicament injection device comprising: a main body; a medicament cartridge holder fixed with respect to the main body, wherein the medicament cartridge holder is configured to hold a medicament cartridge; a needle carrier carrying a needle, wherein the needle carrier is axially movable with respect to the main body; and a rotatable cap at a distal end of the device, wherein the cap comprises a first pre-stressed spring coupled to the needle carrier, wherein the cap is arranged so that rotational movement thereof causes release of the first pre-stressed spring thereby causing the needle carrier to move axially towards a proximal end of the device. | 2018-12-27 |
20180369499 | SYRINGES WITH RETRACTABLE NEEDLE - The syringe can have a plunger body and a plunger seal both independently slidingly engaged within a cavity of a barrel for movement along a common longitudinal axis, and a needle anchored to the plunger body and extending across the plunger seal, the needle having an inlet aperture allowing fluid flow communication into an internal conduit of the needle, the barrel having a reservoir for receiving a medical fluid, the reservoir extending between the plunger seal and a bottom, the bottom being closed by a septum. | 2018-12-27 |
20180369500 | Syringe Protecting Device - A syringe protecting device equipped with an outer cylinder, an inner cylinder and a spring, wherein, when the spring is released from its compressed state, the inner cylinder is moved rearward with respect to the outer cylinder so that a syringe needle is stored inside the outer cylinder, and the syringe protecting device further equipped with a releasable pre-locking mechanism for fixing the inner cylinder to the outer cylinder while maintaining the spring in the compressed state in the front-rear direction, wherein, the pre-locking mechanism fixes the inner cylinder before movement to the outer cylinder by engaging the protruding sections of the ring with the engaging sections of the through groove sections. | 2018-12-27 |
20180369501 | SAFETY SYRINGE AND NEEDLE SHIELD - The disclosure pertains to a safety syringe having a retractable needle shield which is capable of being retracted to expose the needle for use; being advanced to a needle shielding position; and, if desired, of being removed from the syringe with the shielded needle safely contained within the retractable needle shield via a frangible segment between the syringe barrel and the needle/needle shield components. The disclosure further pertains to a method of using the safety syringe having a retractable needle shield. | 2018-12-27 |
20180369502 | PIERCE EAR HOLE PROTECTOR - The Pierce Ear Hole Protector is a Earrings that is a hypodermic tube with holds on it and goes in the hole of a pierce ear to inject a healing substance to keep a pierce ear from closing or getting infected or sore by a administering a injection to the center of the tube treating area around pierce ear hole with a medicine of choice for pain relief. | 2018-12-27 |
20180369503 | METHOD AND SYSTEM FOR REDUCING PATIENT STRESS DURING PROLONGED SUBCUTANEOUS PHARMACEUTICAL INJECTION - A method for reducing patient stress during prolonged subcutaneous pharmaceutical injection wherein a flexible, nonmetallic sleeve is provided for pharmaceutical delivery. A penetration needle, disposed in the sleeve, allows the flexible sleeve to penetrate a patient's skin. Once the flexible, nonmetallic sleeve has penetrated a patient's skin the penetration needle is removed and a delivery needle is introduced to an upper and of the sleeve. | 2018-12-27 |
20180369504 | METHOD AND APPARATUS FOR APPLYING AN ANESTHETIC AND BACTERICIDE - A method and an apparatus for applying an anesthetic includes a receptacle having an upper end, a substantially hollow interior, a lower end having a tube or nozzle extending therefrom, and an attachment for attaching to the barrel of a syringe or vice versa. The receptacle receives a container or canister containing an endothermic gas or vapor(propellant) that rapidly absorbs heat when released to the atmosphere. A depressible actuating member or trigger propels the gas or vapor through an outlet nozzle that is oriented to project a stream of gas or vapor along a delivery axis that intersects a delivery axis of the needle, therefore, the gas or vapor can be successively delivered to an injection site with minimal repositioning of the housing. | 2018-12-27 |
20180369505 | TREATMENT DEVICE AND METHOD FOR CONTROLLING SAME - The present invention relates to a treatment device and a method for controlling the same, and provides a treatment device comprising: an insertion unit formed to be insertable in tissue after penetrating through a surface of the tissue; a displacement measuring unit for measuring displacement of the surface of the tissue, caused by an insertion of the insertion unit; and a control unit for controlling an insertion motion of the insertion unit on the basis of the displacement measured by the displacement measuring unit. According to the present invention, the device allows medical treatment in a state in which the insertion unit has been inserted to reach a precise position of a target, so as to improve an effect of medical treatment. | 2018-12-27 |
20180369506 | MEDICAMENT DELIVERY DEVICE HAVING AN ELECTRONIC CIRCUIT SYSTEM - Medicament delivery devices are described herein. In some embodiments, an apparatus includes a medical injector and an electronic circuit system. The medical injector includes a housing, a medicament container, and a medicament delivery member. The housing defines a first region and a second region. The first region includes the medicament container and is physically isolated from the second region. The electronic circuit system is configured to be disposed within the second region defined by the housing. The electronic circuit system is configured to output an electronic output associated with a use of the medical injector. | 2018-12-27 |
20180369507 | MEDICAL NEBULIZER WITH IMPROVED STRUCTURE - A medical nebulizer with improved structure, the medical nebulizer comprising a first housing and a second housing, the first housing integrally formed a first nozzle, the first nozzle has a first nozzle hole, the second housing integrally formed a second nozzle and a conical cover, the second nozzle has a second nozzle hole, the inside of the conical cover has a protrusion and an annular inclined surface, the protrusion formed a impacting surface to produce aerosol; wherein the second housing is separable assembled to the first housing, the second nozzle is located on the outside of the first nozzle, a fluid passage is formed between the first nozzle and the second nozzle, the first nozzle hole is located on the inside of the second nozzle hole, the impacting surface is located above the second nozzle hole. | 2018-12-27 |