52nd week of 2015 patent applcation highlights part 37 |
Patent application number | Title | Published |
20150369732 | METHOD OF CHARACTERIZING INTERACTIONS AND SCREENING FOR EFFECTORS - This invention enables high throughput detection of small molecule effectors of particle association, as well as quantification of association constants, stoichiometry, and conformation. “Particle” refers to any discrete particle, such as a protein, nucleic acid, carbohydrate, liposome, virus, synthesized polymer, nanoparticle, colloid, latex sphere, etc. Given a set of particle solutions having different concentrations, dynamic light scattering measurements are used to determine the average hydrodynamic radius, r | 2015-12-24 |
20150369733 | DYNAMIC LIGHT SCATTERING MEASUREMENT DEVICE AND DYNAMIC LIGHT SCATTERING MEASUREMENT METHOD - A dynamic light scattering measurement device includes an irradiation section that applies light emitted from a low-coherence light source to a sample that includes particles, a spectral intensity acquisition section that disperses reflected light from a reference plane and scattered light from the sample that has passed through the reference plane to acquire a spectral intensity of interference light of the reflected light and the scattered light, the reference plane being situated to intersect an optical path through which the light is applied to the sample, and a measurement section that measures dynamic light scattering of the sample based on the acquired spectral intensity. | 2015-12-24 |
20150369734 | OPTICAL MODULE - An optical module is disclosed. The optical module includes: a package substrate; an optical device disposed on the package substrate; a clear mold disposed on the package substrate and the optical device; an light blocking mold disposed on the package substrate, surrounding an optical device on the package substrate, and having an opening above the optical device; and a flexible buffer layer disposed on the light blocking mold. The light blocking mold and the flexible buffer layer are integrally formed of light blocking materials different from each other. An optical module including a plurality of optical devices is also disclosed. | 2015-12-24 |
20150369735 | Chemical Sensors Based on Plasmon Resonance in Graphene - Techniques for forming nanoribbon or bulk graphene-based SPR sensors are provided. In one aspect, a method of forming a graphene-based SPR sensor is provided which includes the steps of: depositing graphene onto a substrate, wherein the substrate comprises a dielectric layer on a conductive layer, and wherein the graphene is deposited onto the dielectric layer; and patterning the graphene into multiple, evenly spaced graphene strips, wherein each of the graphene strips has a width of from about 50 nanometers to about 5 micrometers, and ranges therebetween, and wherein the graphene strips are separated from one another by a distance of from about 5 nanometers to about 50 micrometers, and ranges therebetween. Alternatively, bulk graphene may be employed and the dielectric layer is used to form periodic regions of differing permittivity. A testing apparatus and method of analyzing a sample using the present SPR sensors are also provided. | 2015-12-24 |
20150369736 | DRYNESS FRACTION DISTRIBUTION MEASURING DEVICE AND DRYNESS FRACTION DISTRIBUTION MEASURING METHOD - A dryness fraction measuring device, including a variability quantity measuring portion that measures the amount of variability in intensity of light that has been transmitted, or amount of light that has been absorbed, by moist steam that is the subject of measurement; and a dryness fraction measuring portion that measures the dryness fraction of the moist steam based on a correlation relationship between the dryness fraction and the amount of variability in the optical intensity or in the amount of light absorption. | 2015-12-24 |
20150369737 | System and Method for Simultaneous Detection of Secondary Electrons and Light in a Charged Particle Beam System - A method and system for the imaging and localization of fluorescent markers such as fluorescent proteins or quantum dots within biological samples is disclosed. The use of recombinant genetics technology to insert “reporter” genes into many species is well established. In particular, green fluorescent proteins (GFPs) and their genetically-modified variants ranging from blue to yellow, are easily spliced into many genomes at the sites of genes of interest (GoIs), where the GFPs are expressed with no apparent effect on the functioning of the proteins of interest (PoIs) coded for by the GoIs. One goal of biologists is more precise localization of PoIs within cells. The invention is a method and system for enabling more rapid and precise PoI localization using charged particle beam-induced damage to GFPs. Multiple embodiments of systems for implementing the method are presented, along with an image processing method relatively immune to high statistical noise levels. | 2015-12-24 |
20150369738 | RED FLUORESCENT ALDEHYDE DEHYDROGENASE (ALDH) SUBSTRATE - A detectable substrate for aldehyde dehydrogenase (ALDH) can be used for selecting cells that express ALDH. The detectable substrate can have a fluorescent moiety that has an excitation wavelength, an emission wavelength, or both, that does not overlap with the excitation wavelength, emission wavelength, or both, of green fluorescent protein. | 2015-12-24 |
20150369739 | SEMI-SYNTHETIC QUORUM SENSORS - Described is a device comprising a substrate, and a quorum sensor array on the substrate. The quorum sensor array comprises quorum sensors that release signal molecules in response to one or more environmental signals being sense by the quorum sensors to thereby amplify the one or more environmental signals by causing a signal chain reaction in neighboring quorum sensors of the quorum sensor array. Each of the quorum sensors comprises a lipid multilayer structure. Also described is a method comprising providing data for changes in optical properties of at least part of the quorum sensor array in response to exposing the quorum sensor array to one or more environmental signals, and determining the presence of the one or more environmental signals based on the data. | 2015-12-24 |
20150369740 | OPTOGENETIC PROBES FOR MEASURING MEMBRANE POTENTIAL - Provided herein are variants of an archaerhodopsin useful for application such as optical measurement of membrane potential. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, cells comprising the polynucleotides, and cells comprising the polypeptides; and methods of using the variants. | 2015-12-24 |
20150369741 | URINE SPECIMEN ANALYSIS DEVICE AND URINE SPECIMEN ANALYSIS METHOD - A urine specimen analysis device includes a specimen drawing portion, a sample preparing portion, a measurement portion, and an information processing portion. The specimen drawing portion draws a first aliquot and a second aliquot from a urine specimen. The sample preparing portion prepares a first measurement sample by mixing the first aliquot and a first staining dye that stains red blood cells, and a second measurement sample by mixing the second aliquot and a second staining dye that stains nucleic acids. The measurement portion measures fluorescence emitted from the first measurement sample prepared by the sample preparing portion, and fluorescence emitted from the second measurement sample prepared by the sample preparing portion. The information processing portion detects at least red blood cells contained in the first measurement sample based on the fluorescence of the first measurement sample measured by the measurement portion, and at least white blood cells contained in the second measurement sample based on the fluorescence of the second measurement sample measured by the measurement portion. | 2015-12-24 |
20150369742 | MEASURING APPARATUS AND MEASURING METHOD - Provided is a measuring apparatus including: a light source unit to emit pulsed laser light used for pump light and Stokes light that excite a molecular vibration of a sample; a Stokes light generating unit to modulate an intensity of the pulsed laser light and to generate Stokes light using the pulsed laser light having the modulated intensity; a time delaying unit to delay the pump light using the pulsed laser light or the Stokes light; a detecting unit to detect, by lock-in detection, light transmitted through the sample irradiated with the pump light and the Stokes light having a controlled time delay amount, or reflected light from the sample; and an arithmetic processing device to perform arithmetic processing on the basis of anti-Stokes light detected by the lock-in detection while controlling the intensity modulation and the time delay amount. | 2015-12-24 |
20150369743 | DETERMINING PERCENT SOLIDS IN SUSPENSION USING RAMAN SPECTROSCOPY - Methods and apparatus are provided for determining weight percent of solids in a suspension using Raman spectroscopy. The methods can be utilized to acquire Raman spectral data from the suspension and to determine weight percent of solids in a process being carried out, for example, in a vessel, without the need to remove samples for analysis. The weight percent of the solids can be determined with a desired accuracy in a relatively short time, typically 10 minutes or less. The acquired Raman spectral data may be processed by chemometric software using, for example, a partial least squares algorithm and data pretreatment to provide a predicted value of weight percent solids. In some embodiments, the invention is used to determine the weight percent of microparticles of a diketopiperazine in an aqueous solution. | 2015-12-24 |
20150369744 | NANOSCALE STRUCTURES ON OPTICAL FIBER FOR SURFACE ENHANCED RAMAN SCATTERING AND METHODS RELATED THERETO - A nanoscale structure fabricated on a planar end facet of an optic fiber is described, to enable detection of molecules by surface-enhanced Raman scattering. The nanoscale structure may comprise an array of nanopillars. The nanoscale structure may also comprise a non periodic, or random, surface-relief structure. The nanoscale structure may be coated in a metal, comprising, for example, silver, gold, aluminum, iridium, platinum, palladium, copper, or a combination of the same. The nanoscale structure may be fabricated on a planar end facet of an optical fiber by interference lithography. | 2015-12-24 |
20150369745 | FLUID ANALYSIS SHEET, FLUID ANALYSIS CARTRIDGE INCLUDING THE SAME, AND METHOD OF MANUFACTURING FLUID ANALYSIS CARTRIDGE - Provided is a fluid analysis cartridge configured to analyze a fluid specimen, a fluid analysis sheet forming the same and a method of manufacturing the fluid analysis cartridge. The fluid analysis sheet includes at least one cut out part configured to form an intermediate layer of an inspection substrate, the cut out part including a flow passage structure including an inlet part in which a fluid is introduced and an inspection part in which the fluid is introduced to react with a reagent; and wherein the cut out part is further configured to include a first end adjacent to the inspection part and a second end adjacent to the inlet part, and wherein a minimum distance between the first end and the flow passage structure is at least 1 mm. | 2015-12-24 |
20150369746 | CHEMOSENSORS, COMPOSITIONS AND USES THEREOF - Novel Zr-based metal-organic framework (MOF) chemosensors useful for detection, recognition, removal, and separation of heavy metals are provided. Also provided are methods for preparation of the chemosensors and processes for detection, recognition, removal, and separation of heavy metals using the chemosensors. | 2015-12-24 |
20150369747 | DEVICE AND METHOD FOR DETECTION OF HUMIDITY-COMPROMISED URINE TEST STRIPS - The timing of the reaction of moisture-sensitive reagents for detecting the presence of analytes, e.g. leukocytes in urine samples, is used to detect when the reagents have been compromised by excess humidity. The ratio of light reflectance at wavelengths characteristic of the products of reaction between the reagents and the analyte and an infra-red reference dye is measured at two preset times after a urine sample has been applied to a test strip and used to determine whether the reagents have been compromised by excessive humidity. The presence of unusually dark samples is determined from the reflected light at 470 and 625 nm in order to confirm that the test strips are humidity-compromised. | 2015-12-24 |
20150369748 | FILM EDGE DETECTING METHOD AND FILM EDGE DETECTING DEVICE - The present invention provides a film edge detecting method and a film edge detecting device. The film edge detecting method is used for detecting a film edge of a film layer formed on a substrate, the film layer comprises a patterned film layer, the method includes: forming at least one scale pattern in the patterned film layer, a film edge of the patterned film layer corresponding to an edge of the scale pattern; obtaining a patterned film edge indication value of the edge of the scale pattern; and obtaining a second distance, which is a distance between the film edge of the non-patterned film layer and a corresponding edge of the substrate, based on the non-patterned film edge indication value and a preset reference value of the corresponding edge of the substrate. | 2015-12-24 |
20150369749 | SYSTEM AND METHOD FOR DETECTING PIN-HOLES IN FIBERGLASS AND COMPOSITE PARTS - A system and method is disclosed for detecting defects in the surface of a workpiece such as a fiberglass or composite part. A light source is positioned to direct light at the workpiece at an oblique angle with respect to the surface of the workpiece. At least one camera is positioned to detect light reflected from the workpiece and to generate a light signal corresponding to the reflected light. A polarizing lens is positioned between each of the at least one cameras and the workpiece. A processor is coupled to each of the at least one cameras to receive the corresponding light signals. The processor is programmed to process the light signals to detect any defects in the surface of the workpiece based on relative magnitudes of the received light signal. A video display and a printer are preferably coupled to the processor to show any detected defects. | 2015-12-24 |
20150369750 | Confocal Line Inspection Optical System - A line scan wafer inspection system includes a confocal slit aperture filter to remove sidelobes and enhance resolution in the scanning direction. A position detector associated with the slit aperture filter monitors and corrects illumination line image positions relative to the slit aperture to keep image position variations within tolerable limits. Each detector measures a line position and then uses the line position signal to adjust optical, mechanical, and electronic components in the collection path in a feedback loop. The feedback loop may be employed in a runtime calibration process or during inspection to enhance stability. | 2015-12-24 |
20150369751 | DEVICE AND METHOD FOR TRANSFORMER IN-SITU INSPECTION - An inspection device for use in a fluid container having at least an opening includes a housing sized to fit through the opening. The housing has at least two fluid flow channels extending therethrough, each having an inlet and an outlet, and a pump maintained in the housing within each fluid flow channel. The pumps are selectively controlled to maneuver the housing within the fluid container. The inspection device continues with a method of in-situ inspection of a container having at least one opening to receive a fluid, that includes up-loading a virtual model of the container into a computer, inserting the device into the container, generating a position signal by the device and receiving the position signal on a computer. A virtual image of the device in the virtual model of the container is generated to determine an actual position of the device within the container. | 2015-12-24 |
20150369752 | DEFECT INSPECTION DEVICE AND DEFECT INSPECTION METHOD - In an defect inspection method and device, in order to detect a minute defect present on a surface of a sample with a high degree of sensitivity, a defect inspection method includes imaging the same region of a sample in a plurality of image acquisition conditions and acquiring a plurality of images, processing the plurality of acquired images and extracting a defect candidate, clipping a partial image including the extracted defect candidate and a neighboring image of the defect candidate from the acquired images based on position information of the extracted defect candidate, obtaining feature quantities of the defect candidates in the plurality of clipped partial images, associating the defect candidates that have the same coordinates on the sample and are detected in different image acquisition condition, extracting a defect from among the associated defect candidates in a multi-dimensional feature quantity space, and outputting information of the extracted defect. | 2015-12-24 |
20150369753 | Wafer Inspection - Systems configured to inspect a wafer are provided. One system includes an illumination subsystem configured to direct pulses of light to an area on a wafer; a scanning subsystem configured to scan the pulses of light across the wafer; a collection subsystem configured to image pulses of light scattered from the area on the wafer to a sensor, wherein the sensor is configured to integrate a number of the pulses of scattered light that is fewer than a number of the pulses of scattered light that can be imaged on the entire area of the sensor, and wherein the sensor is configured to generate output responsive to the integrated pulses of scattered light; and a computer subsystem configured to detect defects on the wafer using the output generated by the sensor. | 2015-12-24 |
20150369754 | CONTAINER HANDLING DEVICE FOR HANDLING CONTAINERS, SUCH AS BOTTLES OR SIMILAR CONTAINERS DESIGNED TO HOLD A BEVERAGE OR A SIMILAR PRODUCT - A container handling device for handling containers, such as bottles or similar containers designed to hold a beverage or a similar product. The abstract of the disclosure is submitted herewith as required by 37 C.F.R. §1.72(b). As stated in 37 C.F.R. §1.72(b): A brief abstract of the technical disclosure in the specification must commence on a separate sheet, preferably following the claims, under the heading “Abstract of the Disclosure.” The purpose of the abstract is to enable the Patent and Trademark Office and the public generally to determine quickly from a cursory inspection the nature and gist of the technical disclosure. The abstract shall not be used for interpreting the scope of the claims. Therefore, any statements made relating to the abstract are not intended to limit the claims in any manner and should not be interpreted as limiting the claims in any manner. | 2015-12-24 |
20150369755 | SEMICONDUCTOR DEVICE INSPECTION DEVICE AND SEMICONDUCTOR DEVICE INSPECTION METHOD - A semiconductor device inspection system includes a laser light source for generating light to be irradiated a semiconductor device, an optical sensor for detecting the light reflected by the semiconductor device and outputting the detection signal, a tester unit for applying a operating signal to the semiconductor device, an electricity measurement unit to which the detection signal is input, an electricity measurement unit to which the detection signal and the operating signal are selectively input, and a switching unit having a detection signal terminal and a operating signal terminal. The switching unit inputs the detection signal to the electricity measurement unit by connecting a connection section to the detection signal terminal and inputs the operating signal by connecting the connection section to the operating signal terminal. | 2015-12-24 |
20150369756 | SCANNING APPARATUS - A method of scanning a shoe. The method comprises directing from a source at least one first signal at the shoe, the at least one first signal comprising substantially millimetre and/or microwave radiation, receiving at one or more receivers a plurality of second signals, the plurality of second signals comprising reflections of the at least one first signal from different positions with the shoe. The method further comprises processing each of the second signals to determine a plurality of reflection positions within the shoe and processing the plurality of second signals and reflection positions to generate second data, the second data indicating a composition of the shoe. | 2015-12-24 |
20150369757 | METHOD AND APPARATUS FOR GENERATING A THREE-DIMENSIONAL MODEL OF A REGION OF INTEREST USING AN IMAGING SYSTEM - A method of generating a three-dimensional representation of a region of interest on a target object in an x-ray imaging system. The method uses a fiducial marker of known geometry. The region of interest and the fiducial marker are imaged in a plurality of predetermined positions. Expected images of the fiducial marker for each predetermined position are calculated and compared to captured images of the fiducial marker at each predetermined position. The difference between expected and captured imaged is used to generate corrected images of the region of interest for each predetermined position and these corrected images are used to generate a three-dimensional model of the region of interest. The method allows for the generation of useful three-dimensional models of a region of interest in an x-ray imaging system without requiring an expensive mechanical positioning system. | 2015-12-24 |
20150369758 | METHODS AND APPARATUS FOR DETERMINING INFORMATION REGARDING CHEMICAL COMPOSITION USING X-RAY RADIATION - According to some aspects, a method is provided comprising generating first monochromatic x-ray radiation at a first energy, directing at least some of the first monochromatic x-ray radiation to irradiate subject matter of interest, detecting at least some of the first monochromatic x-ray radiation transmitted through the subject matter of interest, and determining information about a chemical composition of the subject matter of interest based, at least in part, on the detected first monochromatic x-ray radiation and the first energy. | 2015-12-24 |
20150369759 | X-RAY SCATTEROMETRY APPARATUS - Apparatus, including a sample-support that retains a sample in a plane having an axis, the plane defining first and second regions separated by the plane. A source-mount in the first region rotates about the axis, and an X-ray source on the source-mount directs first and second incident beams of X-rays to impinge on the sample at first and second angles along beam axes that are orthogonal to the axis. A detector-mount in the second region moves in a plane orthogonal to the axis and an X-ray detector on the detector-mount receives first and second diffracted beams of X-rays transmitted through the sample in response to the first and second incident beams, and outputs first and second signals, respectively, in response to the received first and second diffracted beams. A processor analyzes the first and the second signals so as to determine a profile of a surface of the sample. | 2015-12-24 |
20150369760 | METHOD OF ELECTRON BEAM DIFFRACTION ANALYSIS - A method is provided for analysing electron backscatter diffraction data generated from a sample material. An image data set representative of an image of electron backscatter diffraction bands is obtained from the sample material. A set of estimated first diffraction parameters is then generated, these defining individual electron backscatter diffraction bands in the image data set. A candidate phase is then selected together with a respective orientation for the material, based upon the generated set of estimated parameters thereby identifying diffraction bands in the image data set. Second diffraction parameters of the identified diffraction bands are simulated for the candidate phase according to the respective orientation. These second diffraction parameters are then adjusted for the identified simulated bands so as to fit the simulated bands to the bands in the image data. A fitted orientation for the candidate phase is then calculated together with a corresponding fitting parameter defining the quality of fit. | 2015-12-24 |
20150369761 | USING MULTIPLE SOURCES/DETECTORS FOR HIGH-THROUGHPUT X-RAY TOPOGRAPHY MEASUREMENT - An apparatus for X-ray topography includes a source assembly, a detector assembly, a scanning assembly and a processor. The source assembly is configured to direct multiple X-ray beams so as to irradiate multiple respective regions on a sample, wherein the regions partially overlap one another along a first axis of the sample and are offset relative to one another along a second axis of the sample that is orthogonal to the first axis. The detector assembly is configured to detect the X-ray beams diffracted from the sample and to produce respective electrical signals in response to the detected X-ray beams. The scanning assembly is configured to move the sample relative to the source assembly and the detector assembly along the second axis. The processor is configured to identify defects in the sample by processing the electrical signals, which are produced by the detector assembly while the sample is moved. | 2015-12-24 |
20150369762 | QUANTITATIVE DETERMINATION OF NITROGEN SPECIES DISTRIBUTION IN DISPERSANTS - The nitrogen species in a long chain alkenyl succinimide are quantitated and speciated by means of X-Ray Photoelectron Spectroscopy with speciation being made by chemometrically curve resolving the XPS spectrum. | 2015-12-24 |
20150369763 | QUANTITATIVE DETERMINATION OF NITROGEN SPECIES DISTRIBUTION IN DISPERSANTS - The distribution of nitrogen species in a long chain alkenyl succinimide dispersants is quantitated and speciated by means of | 2015-12-24 |
20150369764 | SYSTEM AND METHOD FOR TEMPERATURE SENSING OF THREE-DIMENSIONAL INTEGRATED CIRCUIT - A system and a method for temperature sensing of three-dimensional integrated circuits are revealed. The three-dimensional integrated circuit is formed by stacking of a plurality of chip layers that execute specific functions. The chip layer includes a master layer and at least one slave layer. The master layer is disposed with a master temperature sensor while a first thermal conductive part is arranged at the slave layer where heat is detected. The first thermal conductive part and the master temperature sensor are connected by a thermal conductive structure. Thereby temperature of various points at different chip layers is conducted to the same chip layer by Through Silicon Vias to be measured and calibrated. The design complexity and the implementation cost of the temperature sensing system are significantly reduced. | 2015-12-24 |
20150369765 | Method And Device For Material Analysis - Method and thermal analysis device including a sample holder and at least one temperature detector which is assigned to the holder. The invention further relates to a production method for a temperature detector. A heat flow to be detected is conveyed to the temperature detector between a support surface and the sample holder, wherein the support surface and/or the sample holder include elevations or depressions forming contact points, which define a relevant heat flow zone assigned to the support surface. A thermocouple, which includes at least two elements made of different metals, a first metallic element A, with a higher expansion coefficient compared to a second metallic element B, is introduced in a precisely fitting manner into second metallic element B constituted as a hollow profile and the two elements A, B are heated in a first operational step and then cooled again in a second operational step. | 2015-12-24 |
20150369766 | SENSOR DEVICE FOR SENSING A HUMIDITY OF A FLUID MEDIUM - A sensor device includes a housing in which there is a measuring space, a humidity module at least partially disposed within the measuring space and that includes a humidity sensor element for sensing humidity of a fluid medium in the measuring space, and a first temperature sensor for sensing a temperature of the fluid medium in the measuring space, and an evaluation unit that performs a method of outputting a first temperature signal of the first temperature sensor that indicates the temperature of the fluid medium in the measuring space, correcting a humidity signal of the humidity sensor element using a second temperature signal, which indicates a temperature of the fluid medium in a region of the sensor device that is thermally decoupled from the evaluation unit, and outputting the corrected humidity signal indicating the humidity of the fluid medium in the measuring space. | 2015-12-24 |
20150369767 | ANISOTROPIC MULTIPHYSICS SENSING SYSTEMS FOR MATERIALS AND METHODS OF USING THE SAME - The present invention is directed to a method to measure a non-electrical property of an object using an electrical property measurement, and applications for the method. The invention is also directed to a transducer, and uses for the transducers. | 2015-12-24 |
20150369768 | CAPACITOR TYPE HUMIDITY SENSOR - A capacitor type humidity sensor is provided, where a reference capacitor (C | 2015-12-24 |
20150369769 | END-FILL ELECTROCHEMICAL-BASED ANALYTICAL TEST STRIP WITH PERPENDICULAR INTERSECTING SAMPLE-RECEIVING CHAMBERS - An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) and/or a characteristic of the bodily fluid sample (e.g., hematocrit) includes a sample-entry chamber with a sample-application opening disposed on an end edge of the electrochemical-based analytical test strip, and first and second sample-determination chambers, each in direct fluidic communication with the sample-entry chamber. The electrochemical-based analytical test strip also includes first and second electrodes (such as first and second hematocrit electrodes) disposed in the first sample-determination chamber, and a third and fourth electrodes (for example working and reference electrodes) disposed in the second sample-determination chamber. Moreover, the first and second sample-determination chambers intersect the sample-entry chamber perpendicular (or nearly perpendicular) to one another and the first sample-determination chamber also intersects the sample-entry chamber in an aligned manner. | 2015-12-24 |
20150369770 | BIOSENSOR AND METHOD FOR MANUFACTURING SAME - The present invention provides a biosensor capable of measuring various blood components, in particular, the concentration of blood glucose with high accuracy even when a hematocrit level varies. The above-described object was achieved by a biosensor | 2015-12-24 |
20150369771 | CO-ELECTRODEPOSITED HYDROGEL-CONDUCTING POLYMER ELECTRODES FOR BIOMEDICAL APPLICATIONS - Bioelectrodes having enhanced biocompatible and biomimetic features are provided. Methods of making and using the bioelectrodes are further provided. A biologically integrated bioelectrode device and method for detecting electronic signals using a bioelectrode comprising a first electrically conductive substrate and a biological component. The bioelectrode also comprises a conductive polymer electrically coupling the first electrically conductive substrate and the biological component to define a bioelectrode. The bioelectrode can transmit or receive an electrical signal between the electrically conductive substrate and the biological component and conductive polymer. | 2015-12-24 |
20150369772 | PROCESSING OF NUCLEOTIDE SEQUENCES - The invention relates to a method and an apparatus ( | 2015-12-24 |
20150369773 | ELECTROCHEMICAL GAS SENSOR SYSTEM - An electrochemical gas sensor system ( | 2015-12-24 |
20150369774 | Carbon Monoxide Sensor System and Method - A gas sensor having first and second electrodes, an ion conducting solid electrolyte membrane positioned therebetween, first and second electrically conductive gas diffusion layers, first and second electrode contact members for electrically coupling said first and second electrodes to an external circuit, a water reservoir, a gas entry passageway and a water permeation barrier for controlling the transport of water vapor to the ion conducting solid electrolyte membrane. The water permeation barrier is a thin walled member which allows water vapor to diffuse therethrough and evaporate from an exit surface, the thickness of the water permeation barrier controlling the internal relative humidity of the sensor. A method for adjusting the present sensor in-situ due to changes in the current humidity conditions of the sensor so as to keep the gas sensitivity loss within a predetermined range is also disclosed. | 2015-12-24 |
20150369775 | ELECTROANALITICAL SYSTEM - An electroanalytical system useful for measuring analytes, such as sugar, sulfites, and ethanol in wine, includes a printed copper electrode in an alkaline medium, a flow injection system to contact very small samples with the copper electrode, current measurement to measure current flowing in a cell containing the copper electrode and a data processor connected to the copper electrode. The copper electrode has a copper oxide surface. Results are obtained by comparing known current flows for particular analytes with the flows obtained for the sample. | 2015-12-24 |
20150369776 | SYSTEMS AND METHODS FOR SINGLE-MOLECULE DETECTION USING NANOPORES - A system and method for detecting a single-molecule using an integrated circuit which includes at least one membrane having a nanopore located between first and second reservoirs and a low-noise preamplifier having an electrode formed on the surface thereof is provided. The method includes passing a target molecule through the nanopore, and measuring a current through the nanopore to detect the presence of a biomolecular entity, if any. | 2015-12-24 |
20150369777 | DISCHARGE IONIZATION CURRENT DETECTOR AND TUNING METHOD FOR THE SAME - An adjusting method for a discharge ionization current detector of the present invention is provided for a discharge ionization current detector for a gas chromatograph, which improves the precision and reproducibility of measurements results of the detector. The discharge ionization current detector adjusts at least one of purity of introduced helium gas, a flow rate of the introduced helium gas, an amplitude of voltage of the low-frequency dielectric barrier discharge, and a frequency of the voltage of the low-frequency dielectric barrier discharge so that intensity of light having a wavelength of 640 nm reaches the maximum in a range of wavelengths of 250 to 700 nm with respect to light emitted by the helium plasma. | 2015-12-24 |
20150369778 | CHEMICAL SENSOR ARRAY AND METHODS OF MAKING AND USING THE SAME - Chemicals sensor arrays are disclosed for detecting analytes in a sample. The chemical sensor array may include two or more vibration detection units. In some embodiments, the vibration detection units each independently include: a piezoelectric element having a first side and a second side; a first electrode disposed on the first side of the piezoelectric element; a second electrode disposed on the first side of the piezoelectric element, wherein the second electrode is spaced apart from the first electrode; and a conductive layer disposed on the piezoelectric element. The conductive layer is spaced apart from the first electrode and the second electrode. Methods of making and using the chemical sensor array are also disclosed. | 2015-12-24 |
20150369779 | WELDING STATE INSPECTION METHOD - A welding state inspection method for ultrasonic-welded plate-like members includes the steps of measuring energy that has been transmitted to an anvil when ultrasonic-welding a plurality of plate-like members stacked on the anvil while pressing a horn that vibrates against the plate-like members; and determining a quality of a welding state of the plate-like members on the basis of the energy measured in the measuring step. | 2015-12-24 |
20150369780 | SYSTEMS AND METHODS FOR VIEWING DATA GENERATED BY ROTATIONAL SCANNING IN NON-DESTRUCTIVE TESTING - The present application relates to a non-destructive testing system. The non-destructive testing system may include an ultrasonic probe and a hand-held display in communication with the ultrasonic probe. The hand-held display may be configured to display C-scan images or S-scan images. | 2015-12-24 |
20150369781 | MEMS FLOW CONTROL CHIP FOR GAS CHROMATOGRAPHY - A micro-electro-mechanical system (MEMS) flow control chip that can control the flow of gas and be configured to operate in a gas chromatography system are disclosed. The MEMS flow control chip can include at least one inlet port in the chip, at least one outlet port in the chip, at least one flow channel between the inlet and outlet ports, and at least one pneumatic valve in the chip for controlling a flow of gas through the flow channel and between the inlet port and outlet ports. Advantageously, the MEMS flow control chip can be positioned in an oven of the a gas chromatography system and have a temperature approximately the same as one or more chromatographic columns of the system. | 2015-12-24 |
20150369782 | CHROMATOGRAPH/MASS SPECTROMETER DATA PROCESSING DEVICE - If multiple polyvalent ion peak candidates with different valences surmised to be derived from the target compound have been obtained, a mass chromatogram in the vicinity of the retention time of the target compound at the mass-charge ratio m/z of each polyvalent ion peak candidate is generated, and these are overlaid and displayed on the display screen. If the polyvalent ions are derived from the same compound, peaks of similar shape having a peak top near the retention time should appear in multiple mass chromatograms. Therefore, the user can check the displayed mass chromatograms and easily determine whether they reflect a combination of polyvalent ions derived from the target compound (a) or not (b). | 2015-12-24 |
20150369783 | ENVIRONMENT EVALUATION APPARATUS AND ENVIRONMENT EVALUATION METHOD FOR CALCULATING AMOUNT OF CARBON DIOXIDE EMISSION REDUCTION - An environment evaluation apparatus comprises an interface and a controller. The interface receives the number of sheets when using the electronic data instead of printing them on the sheets. The controller calculates a carbon dioxide reduction amount as the reduction amount of carbon dioxide emission according to the number of sheets received by the interface, adds the calculated carbon dioxide reduction amount to the carbon dioxide reduction amount stored in a memory and then stores the sum in the memory. | 2015-12-24 |
20150369784 | DEVICE FOR MEASURING RESIDUAL OIL - The invention relates to a measuring device for detecting amounts of hydrocarbon in gases, and comprising—a first sensor ( | 2015-12-24 |
20150369785 | SENSOR DEVICE FOR DETECTING A MOISTURE CONTENT OF A FLOWING FLUID MEDIUM - A sensor device includes a moisture module that includes a sensor element for detecting moisture of a fluid medium flowing in a flow direction and a protective membrane screening the sensor element. The sensor device includes a housing, in a measuring chamber of which the moisture module is at least partially situated, and that includes a protective tube extending into the flowing fluid medium in an axial direction perpendicular to the flow direction, the protective tube is designed for flow of the fluid medium into at least one inlet opening, through an inflow path, into the measuring chamber counter to the axial direction, and out of the measuring chamber via an outflow path in the axial direction and an outlet opening, where, with respect to a direction of gravity, the openings are at a bottom of the protective tube. | 2015-12-24 |
20150369786 | DEVICE AND METHOD FOR MEASURING PLANT GROWTH CONDITIONS | 2015-12-24 |
20150369787 | A METHOD AND SYSTEM FOR MONITORING QUALITY OF BALLAST WATER OF A VESSEL - The present invention relates to a system for monitoring quality of ballast water. The system comprises a central data hub comprising a data hub computer adapted for generating a set of acceptance criteria for ballast water quality parameters at one or more geographic positions based upon uploaded ballast water data from on-board computers of at least two vessels. The uploaded ballast water data indicates where, and possibly when, a volume of ballast water was loaded into a ballast water tank of each of the at least two vessels and the respective values of each of the ballast water quality parameters that are measured on each of the volumes of ballast water. The system for monitoring quality of ballast water further comprises at least two vessels, such as ships, each vessel comprising an on-board ballast water system comprises an on-board computer with a monitor, a data logger, a data storage for storage of a set of acceptance criteria for a number of the ballast water quality parameters corresponding to a geographical position and at least one geographical position. The on-board ballast water system further comprises detection means adapted for logging into the data logger the geographical position where the volume of ballast water is loaded into the ballast water tank and a number of ballast water quality sensors each being adapted for measuring at least one of the ballast water quality parameters of the ballast water in the ballast water piping or in ballast water tank. The on-board ballast water system is further adapted for logging ballast water data comprising a value of each of the ballast water quality parameters into the data logger and the on-board computer being further adapted for downloading the set of acceptance criteria from the central data hub and up-loading the ballast water data and the corresponding geographical position to the central data hub. The on-board computer is adapted to perform a comparison of the values of the ballast water quality parameters with corresponding acceptance criteria corresponding to said geographical position, and to display information on the monitor depending on said comparison. | 2015-12-24 |
20150369788 | Sensor Device, Filter Assembly, and Method for Manufacturing Same - A sensor device for a filter assembly is provided with at least one sensor element that detects an operating parameter of the filter assembly. A fire protection material at least partially encloses the sensor element. The sensor element is a water sensor. The fire protection material comprises an intumescent material. | 2015-12-24 |
20150369789 | CLEANABILITY ASSESSMENT OF SUBLIMATE FROM LITHOGRAPHY MATERIALS - A method of testing the cleanability of polymerized sublimate outgassed from a lithography material during a thermal heating process including; placing a wafer on a wafer hotplate inside a chamber with the wafer being covered by a lithography material; placing a target, having a starting composition, above the wafer in the chamber; heating the wafer using the wafer hotplate in an attempt to outgas a sublimate, where the sublimate condenses on the target; forming a polymerized sublimate on the target; and applying organic solvents to the target to determine the cleanability of the polymerized sublimate. | 2015-12-24 |
20150369790 | AGGREGATED CELL EVALUATION METHOD AND AGGREGATED CELL EVALUATION DEVICE - An aggregated cell evaluation apparatus includes a laser light source, a speckle image acquisition unit, an SC calculation unit, an evaluation unit, and a memory unit. The speckle image acquisition unit acquires a two-dimensional speckle image by forward scattered light generated in aggregated cells by irradiation of the aggregated cells with laser light output from the laser light source. The SC calculation unit calculates a speckle contrast value K | 2015-12-24 |
20150369791 | DEVICES AND SYSTEMS FOR MIMICKING HEART FUNCTION - In an aspect, disclosed herein are physiological devices and systems, and components thereof, used to evaluate cardiac parameters and arrhythmogenic mechanisms. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 2015-12-24 |
20150369792 | DISPENSING MECHANISM FOR TEST STRIPS - A dispensing mechanism for dispensing measurement strips is presented having a strip cartridge with an enclosure for retaining a plurality of measurement strips and a dispensing slot for dispensing one measurement strip at a time, a spring rotatably arranged with respect to the strip cartridge, the spring comprising at least one engagement section adapted to engage one of the measurement strips at a time and move it out of the dispensing slot when the spring is rotated, and a guide slot arranged in the strip cartridge for guiding the engagement section of the spring as the spring is rotated. | 2015-12-24 |
20150369793 | BLOOD ANALYZER, BLOOD ANALYZING METHOD, AND NON-TRANSITORY STORAGE MEDIUM - A blood analyzer comprises a sample preparing part, a light source, a light receiving part, and a processing part configured to discriminate and count reactive B lymphocytes based on at least one of fluorescent light signals and forward scattered light signals. | 2015-12-24 |
20150369794 | Method for Identifying of a Biological Sample of a Mammal, Composition for use in this method and Kit for Performance of this Method - The invention relates to a method through which a biological sample of a mammal can be precisely assigned and identified, as well as a kit for performance of this method and a composition comprising at least one essentially non-metabolizable marker substance and a dye useable in the method and the kit. | 2015-12-24 |
20150369795 | PORTABLE METABOLIC ANALYZER SYSTEM - A system for measuring and tracking metabolic rate, physical activity and calorie intake. The metabolic rate is measured with a design that features an adaptive sampling mechanism for accurate breath sample collection, optimized flow rate measurement for minimizing backpressure while maximizing accuracy, humidity regulation and water condensation reduction mechanism for reliable performance, as well as breath temperature measurement for volume and humidity corrections. The system further comprises an improved algorithm for determining physical activity such as related energy expenditure, and a mechanism for tracking changes in food intake over time. | 2015-12-24 |
20150369796 | METASTASIS MIMETIC DEVICE - Implementations of the present invention relate to apparatuses, systems, and methods for constructing and using a metastatic mimetic device. The device includes at least one chamber with a gate structure that allows a channel to selectively allow fluid communication between an interior of the chamber and an exterior of the chamber. The channel includes a porous member extending across a cross-section of the channel to control flow rates or allow the mimetic device to replicate transport across a member. | 2015-12-24 |
20150369797 | METHOD FOR IMAGING CELL USING FLUORESCENCE-LABELED SUGAR DERIVATIVE HAVING COUMARIN DERIVATIVE BOUND THERETO, AND IMAGING AGENT - The present invention has an object of providing a sugar derivative emitting blue fluorescence color which can be used for imaging of cells or intracellular molecules and a method for imaging cells using the derivative. Further, the present invention has an object of providing a method for detecting cancer cells at high accuracy by imaging, and an imaging agent used for this method. The present invention provides a fluorescently labeled sugar derivative having 3-carboxy-6,8-difluoro-7-hydroxycoumarin or 3-carboxymethyl-6,8-difluoro-7-hydroxy-4-methylcoumarin as a fluorescent molecular group in its molecule, and a cell imaging agent and an imaging method using the derivative. Further, the present invention provides an imaging agent and an imaging method for cancer cells using an L-glucose derivative having the above-described fluorescent molecular group in its molecule. | 2015-12-24 |
20150369798 | Apparatus for Improved Disease Detection - An apparatus for detecting a disease in a biological subject comprises a delivery system and at least two sub-equipment units which are combined or integrated in the apparatus, wherein the delivery system is capable of delivering the biological subject to at least one of the sub-equipment units and each sub-equipment unit is capable of detecting at least one property of the biological subject. Methods for detecting a disease with the apparatus are also provided. | 2015-12-24 |
20150369799 | METHOD FOR SUPPRESSING FALSE NEGATIVE IN IMMUNOASSAY FOR DERIVED FROM BIOLOGICAL MUCOUS MEMBRANE - The problem to be solved is accurately and specifically detecting a target substance by suppressing the action of an immunoassay inhibitory substance contained in a specimen derived from a biological mucous membrane. A false negative can be suppressed by treating a specimen with a specimen treatment solution containing a compound having two or more sulfate groups in immunoassay for analyzing a target substance in a specimen derived from a biological mucous membrane. | 2015-12-24 |
20150369800 | HIGH-SENSITIVE FLUORESCENT ENERGY TRANSFER ASSAY USING FLUORESCENT AMINO ACIDS AND FLUORESENT PROTEINS - The disclosure provides method and composition utilizing fluorescent amino acids and fluorescent proteins comprising a moiety capable of undergoing FRET. The methods and compositions of the disclosure are useful in analyzing protein structure and function, and screening molecular inhibitors. | 2015-12-24 |
20150369801 | Method for Detecting and/or Quantifying the Binding Affinities of a Target Molecule to a Plurality of Different Binding Partners by Plasmon Resonance of Nanoparticles and a Position-Encoded Sensor Therefor - A method for detecting and/or quantifying the binding affinities of one sort of target molecule to a plurality of different binding partners includes using plasmon resonance of nanoparticles, and a position-encoded sensor to measure shifts in the plasmon resonance of the nanoparticles when the target molecule is bound thereto. | 2015-12-24 |
20150369802 | Biomolecule Binding Composite Surfaces, Methods Of Making Such Surfaces, Devices Incorporating Such Surfaces, And Methods Of Using Such Surfaces In Biomolecule Binding Assays, And Devices Therefor - The present invention relates to novel microporous, biomolecule binding composite surfaces. It also relates to processes for making such surfaces. It also relates to processes for incorporating such surfaces into assay devices, and the resulting assay devices. It also relates to readable biomolecule binding assay devices and methods of using such devices in protein microarrays or immunoassays. | 2015-12-24 |
20150369803 | LOW FLUORESCENCE UTENSILS - Method of reducing background fluorescence and corresponding utensils are provided. Utensils such as those used for fluorescence measurements in many fields are coated by a coating comprising porous fractal ceramic layer(s). The ceramic layer is produced by reactive vapor deposition and comprises oxides of aluminum, titanium, tantalum, niobium, zirconium, silicon, thorium, cadmium or tungsten. The coating is configured to exhibit hemispherical reflectance of less than 2% over a range of wavelengths ranging from 0.1-10 μm. The coating achieves high resolution by applying fine deposition and ablation patterns and due to its porousness, and is non-toxic and non-outgassing. | 2015-12-24 |
20150369804 | CAPTURE AND RELEASE OF PARTICLES FROM LIQUID SAMPLES - Systems, methods, and devices for selective capture and release of target particles, e.g., living cells, from liquid samples, e.g., blood, are provided. The particle capture systems include a substrate; a first layer of gelatin bound to the substrate by physical adsorption, wherein the gelatin is functionalized with a plurality of first members of a binding pair; a second layer of gelatin wherein the gelatin is functionalized with a plurality of the first members of the binding pair and the second layer is bound to the first layer via a plurality of second members of the binding pair that are associated with the first members of the binding pair on both the first and the second layers; and a plurality of nanostructures bound to the second members of the binding pair and to one or more particle-binding moieties that selectively bind to the target particles. | 2015-12-24 |
20150369805 | ANALYTE SENSORS, METHODS FOR PREPARING AND USING SUCH SENSORS, AND METHODS OF DETECTING ANALYTE ACTIVITY - Analyte sensors, methods for producing and using analyte sensors, methods of detecting and/or measuring analyte activity, detecting pH change, and/or, controlling the concentration of an analyte in a system, are disclosed. Embodiments of the analyte sensors according to the disclosure can provide an accurate and convenient method for characterizing analyte activity, detecting pH change, controlling the concentration of an analyte in a system, and the like, in both in vivo and in vitro environments, in particular in living cell imaging. | 2015-12-24 |
20150369806 | DETECTION OF VIRAL DISEASES USING A BIOCHIP THAT CONTAINS GOLD NANOPARTICLES - A sensor for detecting molecular interactions between a target and a binding domain by electrochemical impedance spectroscopy. The sensor includes an anodic aluminum oxide barrier layer having a gold-coated array of regularly spaced nano-hemispheres and gold nanoparticles coated with a binding domain attached thereto. Also provided are methods for producing the sensor and for using the sensor to detect the presence of a virus in a sample. | 2015-12-24 |
20150369807 | METHODS AND DEVICES FOR DETERMINING A DISEASE STATE - The present invention, in some embodiments thereof, relates to methods and devices for determining a disease state in a patient. In some embodiments, human serum albumin may be analyzed for associated molecules, wherein the associated molecules are related to a disease such as cancer. Certain aspects of the invention are generally directed to devices and methods for determining a disease state as a function of the three-dimensional structure of a blood protein, human serum albumin (HSA) or its complex with other ligands, e.g., due to binding to disease-specific ligands. HSA interacts with biomolecules associated with a disease presence, and liganded HSA may differentially partition between aqueous phases of a predetermined partitioning system, wherein the partitioning behavior differs between HSA from healthy individuals and HSA from people harboring the predetermined disease, such as breast cancer. | 2015-12-24 |
20150369808 | METHODS AND PRODUCTS FOR PROGNOSING THE CLINICAL EVOLUTION, OR PREDICTING THE RECURRENCE RISK, OF A PAPILLARY LESION OF THE BREAST - The present invention relates to in vitro methods and products for prognosticating clinical progression or predicting the risk and type of recurrence of a papillary lesion of the breast based on proCOL11A1 protein expression, for the purpose of determining the treatment and follow-up regimen that are most suited to each patient. | 2015-12-24 |
20150369809 | TARGETING PHOSPHOFRUCTOKINASE AND ITS GLYCOSYLATION FORM FOR CANCER - The present invention relates to methods of treating cancer, suppressing or inhibiting tumorigenesis, tumor growth or cancer progression, and suppressing or inhibiting cancer cells from altering cellular metabolism in favor of cancerous growth. Also provided are compositions comprising an agent that decreases glycosylation of phosphofructokinase 1 or increases phosphofructokinase 1 expression or activity. | 2015-12-24 |
20150369810 | ANAPLASTIC LYMPHOMA KINASE IN KIDNEY CANCER - The invention provides methods to identify, diagnose, and treat kidney cancer through the detection of expression and/or activity of anaplastic lymphoma kinase (ALK). The detection of the presence of a polypeptide with ALK kinase activity (e.g., by detecting expression and/or activity of the polypeptide), identify those kidney cancers that are likely to respond to an ALK-inhibiting therapeutic. | 2015-12-24 |
20150369811 | METHODS FOR PREDICTING THE SURVIVAL TIME OF A PATIENT SUFFERING FROM A SOLID CANCER - The present invention provides methods and kits for the prognosis of survival time of a patient suffering from a cancerous tumor. The method involves quantitating the density of Th17 cells at the center of the tumor and at the invasive margin of the tumor, where low density values at each location indicate a favourable prognosis, high values at each location indicate an unfavourable prognosis, and heterogeneous values at the two locations (one high, one low) indicate an intermediate prognosis. | 2015-12-24 |
20150369812 | FLAVONOID COMPOUNDS OF LOW TOXICITY FOR BIOLOGICAL IMAGING APPLICATIONS - Flavonoid compounds that are selective for a protein, a portion or a living cell, or a portion of an organism may be used as biological imaging agents. The flavonoid compounds are useful for methods of imaging organisms such as zebrafish embryos and zebra fish. Flavonoid compounds may also be used to detect protein. Advantageously, flavonoids that selectively bind protein, a portion of a living cell, or a portion of an organism may exhibit a florescence “turn-on” mechanism, where the flavonoids that are selectively bound exhibit a florescence response when excited. | 2015-12-24 |
20150369813 | ANALYTICAL TEST STRIP WITH TIERED CAPILLARY CHAMBER - An analytical test strip for the determination of an analyte (such as glucose) in, or a characteristic of, a bodily fluid sample includes an electrically-insulating base layer, a first patterned spacer layer disposed on the electrically-insulating base layer, a second patterned spacer layer disposed on the first patterned spacer layer; and a top hydrophilic layer disposed on the second patterned spacer layer. In addition, the electrically-insulating base layer, the first and second patterned spacer layers and the top hydrophilic layer define a tiered capillary chamber(s) that has a first tiered capillary chamber portion defined in the first patterned spacer layer and a second tiered capillary chamber portion defined in the second patterned spacer layer. Moreover, the first tiered capillary chamber portion and the second tiered capillary chamber portion are in direct fluidic communication with one another. | 2015-12-24 |
20150369814 | USE OF RNA REMOVAL TO INITIATE PROTEIN AGGREGATION - The present invention provides the use of RNA removal to initiate protein aggregation of a plurality of proteins in a cell or cell lysate. This may be used to create an in vitro model of a disease, such as a neurodegenerative disease. The present invention also provides a method for determining the efficacy of a potential anti-protein aggregation agent comprising the following steps: i) using RNA removal to initiate the aggregation of a protein in a cell or cell lysate, ii) treating the cell or cell lysate with the potential anti-protein aggregation agent before, after or during RNA removal; and iii) comparing protein aggregation in equivalent samples with and without step ii) treatment in which a decrease in protein aggregation associated with step ii) treatment indicates that the potential anti-protein aggregation agent is effective in preventing and/or reversing protein aggregation. | 2015-12-24 |
20150369815 | METHOD FOR DETECTING THE PRESENCE OF A GYNAECOLOGICAL GROWTH - The invention relates to a method for detecting the presence of a gynaecological growth, in particular for the diagnosis of endometriosis. The invention also relates to a method of identifying a biomarker for detecting the presence of a gynaecological growth and to biomarkers identified by said method. | 2015-12-24 |
20150369816 | Polypeptide Immobilization - The present invention provides a method, comprising (a) providing a reactant ligand attached to a substrate; (b) contacting the substrate with a fusion polypeptide, said fusion polypeptide comprising a capture polypeptide fused to a display polypeptide under conditions such that said reactant ligand covalently binds to said capture polypeptide; and (c) analyzing said display polypeptide. | 2015-12-24 |
20150369817 | PLATELET BIOMARKERS IN CANCER DIAGNOSIS - The present embodiments relate generally to the field of cancer diagnostics. More specifically the embodiments relate to platelet derived biomarkers used for diagnosis of cancer or cancer progression, as well as prognosis and improved treatment. | 2015-12-24 |
20150369818 | HER3 PROTEIN SRM/MRM ASSAY - The current disclosure provides for specific peptides, and derived ionization characteristics of the peptides, from the Receptor Tyrosine-Protein Kinase erbB-3, or Her3, that are particularly advantageous for quantifying the Her3 protein directly in biological samples that have been fixed in formalin by the method of Selected Reaction Monitoring (SRM) mass spectrometry, or what can also be termed as Multiple Reaction Monitoring (MRM) mass spectrometry. Such biological samples are chemically preserved and fixed wherein said biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (FFPE) tissue/cells, FFPE tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded. A protein sample is prepared from said biological sample using the Liquid Tissue™ reagents and protocol and the Her3 protein is quantitated in the Liquid Tissue™ sample by the method of SRM/MRM mass spectrometry by quantitating in the protein sample at least one or more of the peptides described. These peptides can be quantitated if they reside in a modified or an unmodified form. An example of a modified form of a Her3 peptide is phosphorylation of a tyrosine, threonine, serine, and/or other amino acid residues within the peptide sequence. | 2015-12-24 |
20150369819 | TMEM120A ION CHANNEL MODULATOR - Assays for selecting a candidate modulator of a TMEM120A ion channel and/or a candidate modulator of chronic pain, the steps comprising contacting a lipid membrane comprising contacting a lipid membrane comprising TMEM120A polypeptide with a test compound; quantitating the TMEM120A ion channel activity; comparing the ion channel activity of the TMEM120A polypeptide with a control; and selecting the test compound that modulates the ion channel activity compared to the control; and methods and compositions for treating chronic pain including osteoarthritic pain. | 2015-12-24 |
20150369820 | NOVEL DISEASE-MARKER - The invention relates to the use of soluble CD206 as a general health/disease marker, and a specific marker for liver disorders, sepsis, and pneumonia. | 2015-12-24 |
20150369821 | NOVEL LIPOCALIN-MUTEIN ASSAYS FOR MEASURING HEPCIDIN CONCENTRATION - The present invention relates to lipocalin-mutein assays for measuring hepcidin concentration as well as methods preparing and utilizing and kits leveraging the lipocalin-mutein assays. | 2015-12-24 |
20150369822 | METHOD T0 MAKE AN AQUEOUS POUR POINT DEPRESSANT DISPERSION COMPOSITION - The present invention relates to an aqueous pour point depressant dispersion composition comprising a thermoplastic polymer, preferably ethylene vinyl acetate (EVA); a dispersing agent; water; optionally an aqueous freezing point depressant; and optionally a stabilizing agent wherein the volumn average particle size of the dispersed thermoplastic polymer is equal to or less than 1 micrometers and a method to make and use said composition. | 2015-12-24 |
20150369823 | METHOD TO IDENTIFY PATIENTS THAT WILL LIKELY RESPOND TO ANTI-TNF THERAPY - The present invention identifies various methods for the identification of patients that suffer from an immune system disorder and are likely to benefit from anti-TNF therapy. Because of the significant cost of anti-TNF therapy and the high rate of ineffectiveness of anti-TNF therapy for treating immune disorders such as rheumatoid and psoriatic arthritis, the present invention will improve the delivery of effective therapies to patients in need of either anti-TNF therapy or alternative therapies. | 2015-12-24 |
20150369824 | Methods for treating and diagnosing Systemic Lupus Erythematosus - Methods and reagents for diagnosing, prognosing, and treating systemic lupus erythematosus (SLE) are disclosed, involving calculating an SLE risk score for a subject based on a level of each of an erythrocyte C4d (EC4d) marker, a B-cell C4d (BC4d) marker, antinuclear antibodies (ANA), anti-Smith antibodies (anti-Sm) and optional rule-out markers (SS-B/La, Scl-70, Jo-1, CENP, MCV). | 2015-12-24 |
20150369825 | Diagnosis of Alzheimer Disease, Cognitive Decline and Dementia - The present embodiments relate to the usage of selected protein-derived glycans as biomarkers for diagnosis of Alzheimer disease, cognitive decline and dementia. | 2015-12-24 |
20150369826 | METHOD FOR PREVENTING DETERIORATION OF UNSENSITIZED LATEX REAGENT - Disclosed is novel means for favorably maintaining the dispersed state of a latex reagent in an immunoassay kit and preventing occurrence of coagulation/sedimentation due to temperature changes so that the reagent is protected from deterioration in the measurement performance, which means is also applicable to an immunoagglutination assay kit containing a latex reagent aliquoted in small amounts. The immunoassay reagent of the present invention comprises unsensitized latex particles and trimethylglycine in a solvent. The concentration of trimethylglycine in the reagent is preferably 5 to 10 w/v %. The reagent can be favorably used as an immunoassay reagent for, e.g., hemoglobin A1c. | 2015-12-24 |
20150369827 | REDUCTION OF FALSE POSITIVE ON REAGENT TEST DEVICES - Methods and systems are disclosed including a reagent analyzer, comprising a test analyzing mechanism, such as an optical imaging system, configured to read a first sample of a specimen combined with a reagent configured to react with the sample in a presence of an analyte of interest and a second sample of the specimen that is not combined with a reagent, and to output one or more first signals indicative of the test analyzing mechanism reading the first and second samples; and a processor receiving the one or more first signals and executing logic to analyze the second sample responsive to the processor determining that the analyte of interest is present in the first sample. The processor may execute logic to analyze the second specimen utilizing one or more ratio algorithm and comparing the results of the algorithm against predetermined values indicative of expected color. | 2015-12-24 |
20150369828 | System and Method Incorporating Solid Buffer - A buffered suspension includes a surfactant and a solid buffer particulate having a point of zero charge at least 1.2 pH units different that the pH of the buffered suspension. The buffered suspension can be prepared by mixing a stock solution with the solid buffer particulate and titrating. A method of preforming a pH sensitive process includes drawing the buffered suspension from a reservoir, filtering the solid buffer particulate from the buffered suspension, and applying the filtered solution to a sensor. | 2015-12-24 |
20150369829 | NMR DETECTION OF COAGULATION TIME - The invention relates to detecting coagulation and coagulation-related activities including agglutination and fibrinolysis of samples. More particularly the invention relates to methods and apparatus for monitoring coagulation and/or obtaining a coagulation time of a sample using NMR-based detectors. | 2015-12-24 |
20150369830 | ARTICLES AND METHODS FOR RAPID THC DETECTION - This disclosure describes articles for detecting THC in a saliva sample and methods of using the articles. Generally, the articles include a detection zone that generates a detectable signal that allows one to determine whether the sample contains Δ-9-tetrahydrocannabinol. The methods can produce a test result in rapid fashion, suitable for on-site testing. | 2015-12-24 |
20150369831 | AUTOMATIC ANALYSIS APPARATUS - An automatic analysis apparatus measures a concentration of an intended component in a biological sample, such as blood or urine, or determines whether such component is contained in the sample or not, and includes a function such that, with respect to the optical system, a part whose lifetime has ended is specified or the degree of deterioration of a part is detected to provide a user with the information. The automatic analyzer has a storage unit for storing a transmitted light distribution for a plurality of wavelengths detected by a receptor element for transmitted light which has passed through a substance to be measured, and a control unit for comparing a first, stored transmitted light distribution with a second transmitted light distribution acquired at the time of measurement to determine a deteriorating part from a plurality of parts based on the result of the comparison and output the result. | 2015-12-24 |