51st week of 2010 patent applcation highlights part 44 |
Patent application number | Title | Published |
20100323399 | Use of Trail Polypeptides to Treat Cancer - A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with expression vectors and transformed host cells useful in producing TRAIL polypeptides. Antibodies that specifically bind TRAIL are provided as well. | 2010-12-23 |
20100323400 | Compositions and Methods for Controlling Copy Number for a Broad Range of Plasmids and Uses Thereof - The present invention provides compositions and methods for controlling the copy number for a broad range of plasmids and uses thereof. Disclosed is a host cell for conditional control of copy number of a plasmid, which host cell comprises a poly(A) polymerase gene that is operably joined to a conditionally inducible promoter, and a method for cloning and stably maintaining a DNA sequence encoding a heterologous polypeptide in the host cell. | 2010-12-23 |
20100323401 | GENERAL METHOD FOR GENERATING HUMAN ANTIBODY RESPONSES IN VITRO - This invention relates to an in vitro method of producing antigen specific B cells and antibodies that provides for the capture of an entire primary human antibody repertoire for any foreign antigen, allows for screening large numbers of immunogen/adjuvant combinations, and permits the isolation of human monoclonal antibodies on demand thereby obviating the need to immunize humans with the target antigen. | 2010-12-23 |
20100323402 | UDP-GLUCURONYL TRANSFERASE AND POLYNUCLEOTIDE ENCODING THE SAME - The present invention provides a novel UDP-glucuronosyltransferase and a polynucleotide encoding the same (for example, a polynucleotide comprising a polynucleotide consisting of one nucleotide sequence selected from the group consisting of the nucleotide sequence at positions 1 to 1359 in the nucleotide sequence represented by SEQ ID NO: 4, the nucleotide sequence at positions 1 to 1365 in the nucleotide sequence represented by SEQ ID NO: 10, the nucleotide sequence at positions 1 to 1371 in the nucleotide sequence represented by SEQ ID NO: 12, and the nucleotide sequence at positions 1 to 1371 in the nucleotide sequence represented by SEQ ID NO: 22; or a polynucleotide comprising a polynucleotide encoding a protein having one amino acid sequence selected from the group consisting of SEQ ID NOS: 5, 11, 13 and 23), etc. This provides a novel UDP-glucuronosyltransferase with a broad substrate specificity. | 2010-12-23 |
20100323403 | POLYPURINE TRACT MODIFIED RETROVIRAL VECTORS - An integration-defective retroviral vector transfer cassette lacking a functional polypurine tract (PPT) is provided. Also provided are isolated nucleic acids that include a heterologous nucleotide sequence, one or two retroviral long terminal repeats (LTRs), a packaging signal, a rev responsive element, and a eukaryotic promoter, wherein the nucleic acid lacks a functional PPT; vectors that include the disclosed isolated nucleic acids; recombinant retroviral particles and mRNAs thereof; retroviral vector kits; and methods for producing integration-defective vector particles, achieving gene expression of a nucleotide sequence of interest, and inserting a nucleotide sequence of interest into a host cell genome in a site-specific or non-specific manner. | 2010-12-23 |
20100323404 | METHOD FOR RECOMBINING DNA SEQUENCES AND COMPOSITIONS RELATED THERETO - Provided herein are methods for manipulating nucleotide sequences that permit greater control of sequence recombination compared to traditional methods, and related compositions. In one such method, a set of oligonucleotides and at least one primer are provided, where the primer has a first region uniquely complementary to a sequence of a first oligonucleotide of the set and a second region uniquely complementary to a second oligonucleotide of the set, combining the primer with an oligonucleotide comprising the first region of said first polynucleotide and an oligonucleotide comprising the second region of said second polynucleotide, and PCR amplifying to create a chimeric polynucleotide having some sequence from the first oligonucleotide and some sequence from the second oligonucleotide. | 2010-12-23 |
20100323405 | Droplet-Based Nucleic Acid Amplification in a Temperature Gradient - A method of amplifying a nucleic acid, the method comprising cycling an amplification-ready droplet through a temperature gradient to locations within the temperature gradient suitable for effecting steps in an amplification reaction. | 2010-12-23 |
20100323406 | MUTANT DNA POLYMERASES AND METHODS OF USE - The present invention provides mutant DNA polymerases, polynucleotides encoding the polymerases, cassettes and vectors including such polynucleotides, and cells containing the polymerases, polynucleotides, cassettes, and/or vectors of the invention. The present invention also provides methods for synthesizing polynucleotides and kits including a DNA polymerase of the invention. | 2010-12-23 |
20100323407 | Manufacturing method of separating and purifying neoagarooligosaccharides having degrees of polymerization from 2 to 22 - A manufacturing method of separating and purifying neoagarooligosaccharides having degrees of polymerization of 2-22 includes the steps of adding crude enzyme solutions with agarases produced by | 2010-12-23 |
20100323408 | Mutant Strains of Pseudomonas Fluorescens And Variants Thereof, Methods For Their Production, And Uses Thereof In Alginate Production - It is described biologically pure bacterial cultures of mutant strains of | 2010-12-23 |
20100323409 | PROCESS FOR PRODUCING (2S,3R,4S)-4-HYDROXY-L-ISOLEUCINE - A method for manufacturing (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof using an L-isoleucine-producing bacterium transformed with a DNA fragment containing a gene coding for a protein having L-isoleucine dioxygenase activity; and having the ability to produce (2S,3R,4S)-4-hydroxy-L-isoleucine. | 2010-12-23 |
20100323410 | METHOD FOR PREPARATION OF CARBAMIC ACID (R)-1-ARYL-2-TETRAZOLYL-ETHYL ESTER - Disclosed is a method for the preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester, comprising the asymmetric reduction of arylketone and the carbamation of alcohol. | 2010-12-23 |
20100323411 | PROCESS OF PRODUCING GLUTAMATE DERIVATIVES - The present invention relates to a process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin by converting a substituted α-keto acid of formula (1) into a glutamic acid derivative of formula (2) in the presence of an enzyme catalyzing conversion of the same. | 2010-12-23 |
20100323412 | NOVEL GENE SMS 44 - The present invention relates to novel genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C) and/or 2-keto-L-gulonic acid (hereinafter also referred to as 2-KGA). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to modified proteins and polynucleotides encoding said modified proteins as well as to modified microorganisms, wherein the modification has a direct or indirect impact on yield, production, and/or efficiency of production of Vitamin C and/or 2-KGA in said microorganisms. Also included are processes of using the modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C and/or 2-KGA. | 2010-12-23 |
20100323413 | Production of Oil in Microorganisms - The invention provides methods of manufacturing oils and oil-based products such as transportation fuels, industrial chemicals, edible oils, lubricants and plastics using sucrose feedstocks from sugar cane, sugar beets, and molasses for bioproduction processes. The disclosed processes utilize oleaginous microbes as a conversion technology to convert chemical energy produced by sugar cane, molasses and sugar beets into energy-containing oils and oil derivatives. Also provided herein are oleaginous microbes containing one or more exogenous sucrose utilization genes. | 2010-12-23 |
20100323414 | Production of Oil in Microorganisms - The invention provides methods of producing lipids by oleaginous microorganisms. The invention also provides genetically engineered oleaginous microorganisms and methods of cultivation for lipid production. Also provided are oils, fuels, oleochemicals, chemical precursors, and other compounds manufactured such microorganisms. Exemplary oleaginous microorganisms include oleaginous fungi and such oleaginous fungi that have been genetically modified. | 2010-12-23 |
20100323415 | Emulsions in Enzymatic Reactions - A reaction medium for enzyme-catalyzed reactions is provided, comprising an oil-in-water emulsion including water, an emulsifier, an oil phase and at least one interfacially active enzyme, where the emulsion is produced by the phase inversion temperature process and has a droplet size of 50 to 400 nm. A method for the enzyme-catalyzed esterification, transesterification or hydrolysis of fatty acid alkyl esters and/or triglycerides is also provided where the oil-in-water emulsion is used as the reaction medium. | 2010-12-23 |
20100323416 | Fermentation Method Using A Magnesium Compound Containing Oxygen - This invention is directed to methods of obtaining a high quantity of desired acid salt in a form that is relatively easy to recover. Particularly desired as a recovery product is an organic acid. A salt form of the desired organic acid is formed that is relatively high in concentration and that is relatively soluble in an aqueous medium. The method includes a step of fermenting a fermentable carbon source in the fermentation medium in the presence of a magnesium compound containing oxygen. | 2010-12-23 |
20100323417 | CARBON CAPTURE IN FERMENTATION - The invention relates to methods of capturing carbon by microbial fermentation of a gaseous substrate comprising CO. The methods of the invention include converting CO to one or more products including alcohols and/or acids and optionally capturing CO2 to improve overall carbon capture. In certain aspects, the invention relates to processes for producing alcohols, particularly ethanol, from industrial waste streams, particularly steel mill off-gas. | 2010-12-23 |
20100323418 | ORGANISMS FOR THE PRODUCTION OF ISOPROPANOL, n-BUTANOL, AND ISOBUTANOL - A non-naturally occurring microbial organism having an isopropanol pathway includes at least one exogenous nucleic acid encoding an isopropanol pathway enzyme. The pathway includes an enzyme selected from a 4-hydroxybutyryl-CoA dehydratase, a crotonase, a 3-hydroxybutyryl-CoA dehydrogenase, an acetoacetyl-CoA synthetase, an acetyl-CoA:acetoacetate-CoA transferase, an acetoacetyl-CoA hydrolase, an acetoacetate decarboxylase, and an acetone reductase. A non-naturally occurring microbial organism having an n-butanol pathway includes at least one exogenous nucleic acid encoding an n-butanol pathway enzyme. Other non-naturally occurring microbial organism have n-butanol or isobutanol pathways. The organisms are cultured to produce isopropanol, n-butanol, or isobutanol. | 2010-12-23 |
20100323419 | Methods and Devices for Charged Molecule Manipulation - Systems and methods for manipulating molecular material are provided. In one aspect, for example, a method for manipulating molecular material may include positioning an uncharged needle structure in electrical proximity with a charged molecular material at a first locus in a liquid environment, charging the needle structure such that at least a portion of the charged molecular material becomes associated with the needle structure, moving the needle structure and the first locus relative to one another, and discharging the needle structure to disassociate the charged molecular material at a second locus. | 2010-12-23 |
20100323420 | REGULATED APOPTOSIS - We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins and disclose methods and materials for using that procedure to regulatably initiate cell-specific apoptosis (programmed cell death) in genetically engineered cells. | 2010-12-23 |
20100323421 | METHOD FOR CHEMICALLY MODIFYING BIOPOLYMER AND POLYPEPTIDE - It is an object of the present invention to provide a method for chemically modifying biopolymer and polypeptide with a hydrophobic compound or a compound which causes degradation or reaction under basic condition. The present invention provides a method for producing a chemically modified biopolymer or polypeptide, wherein a biopolymer or polypeptide is chemically modified in a reaction solution containing an organic fluorine compound. | 2010-12-23 |
20100323422 | PEG-Urate Oxidase Conjugates and Use Thereof - A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme. | 2010-12-23 |
20100323423 | PEG-Urate Oxidase Conjugates and Use Thereof - A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme. | 2010-12-23 |
20100323424 | Targeted modification of chromatin structure - Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for facilitating processes such as, for example, transcription and recombination, that require access of exogenous molecules to chromosomal DNA sequences. | 2010-12-23 |
20100323425 | DETECTION OF NUCLEIC ACID DIFFERENCES USING COMBINED ENDONUCLEASE CLEAVAGE AND LIGATION REACTIONS - The present invention is a method for detecting DNA sequence differences including single nucleotide mutations or polymorphisms, one or more nucleotide insertions, and one or more nucleotide deletions. Labeled heteroduplex PCR fragments containing base mismatches are prepared. Endonuclease cleaves the heteroduplex PCR fragments both at the position containing the variation (one or more mismatched bases) and to a lesser extent, at non-variant (perfectly matched) positions. Ligation of the cleavage products with a DNA ligase corrects non-variant cleavages and thus substantially reduces background. This is then followed by a detection step in which the reaction products are detected, and the position of the sequence variations are determined. | 2010-12-23 |
20100323426 | Heterologous and Homologous Cellulase Expression System - The present invention provides filamentous fungi that express a combination of heterologous and homologous polypeptides, polypeptide mixtures comprising a combination of heterologous and homologous polypeptides and methods of producing the polypeptide mixtures. | 2010-12-23 |
20100323427 | INSULIN DEGRADING ENZYME CRYSTALS - The present invention provides apo crystals and co-crystals of insulin-degrading enzyme (IDE) and their uses in drug development. | 2010-12-23 |
20100323428 | ATTENUATED MINUS-STRANDED RNA VIRUS - An objective of the present invention is to provide attenuated minus-strand RNA viruses. The present inventors discovered that the amino acid mutation at position 1214 (Y1214F) in the amino acid sequence of L protein of Sendai virus suppressed the viral genome replication activity and/or transcription activity. The inventors also found that the deletion of a particular gene from the viral genome could result in much less cytotoxicity and immune response than conventional. The inventors thus completed the present invention. | 2010-12-23 |
20100323429 | Methods for purifying baculovirus - The present invention provides a method for purifying baculovirus comprising: providing a baculovirus mixture containing a baculovirus and a liquid portion; replacing the liquid portion with a binding buffer by an ultrafiltration system to form a virus buffer; and purifying the baculovirus from the virus buffer using glycoprotein specific affinity chromatography. Therefore, use of the method of the present invention in the purification of baculovirus resulted in an enhanced discovery yield and improved purity of virus. | 2010-12-23 |
20100323430 | Media For Membrane Ion Exchange Chromatography - Media for chromatographic applications, wherein the media is a membrane having a surface coated with a polymer such as a polyethyleneimine. The immobilized polymer coating is modified with a charge-modifying agent to impart quaternary ammonium functionality to the media. The media is well suited for chromatographic purification of virus. | 2010-12-23 |
20100323431 | BI-STABLE DISPLAY FAIL SAFES AND DEVICES INCORPORATING THE SAME - A control circuit and method for controlling a bi-stable display having bi-stable segments each capable of transitioning between an on state and an off state via application of a voltage are disclosed. The voltage is provided to a display driver from a charge pump, and supplied to individual ones of the bi-stable segments via outputs from the display driver in accordance with display instructions provided by a system controller. Both a bi-stable segment voltage level of at least one of the outputs of the display driver and a charge pump voltage level of the voltage are detected and compared to a valid bi-stable segment voltage level and a valid charge pump voltage level, respectively. A malfunction signal may be provided to the system controller if either of the detected voltage levels is not valid. The control circuit is useful in an electronic device such as, for example, a blood glucose measuring device. | 2010-12-23 |
20100323432 | SAMPLE PROCESSING DEVICE FOR MICROCHIP - A sample processing device for a microchip, including: a sample vessel for packing a sample therein; and a reaction vessel which is continuous with the sample vessel through a channel, and to which the sample is sequentially delivered to be packed and mixed therein, in which the sample is repeatedly delivered between the sample vessel and the reaction vessel through the channel so that the sample is stirred and mixed. | 2010-12-23 |
20100323433 | HINGED CAP FOR DIAGNOSTIC DEVICE - A hinged cap for engaging a housing of a diagnostic device comprises a central body; two arms extending from opposing sides of one end of said central body, said arms being substantially parallel; each of said arms comprising a cap hinge member for engaging a housing hinge member on said housing, wherein said cap hinge member and said housing hinge member define a hinge axis around which said cap is pivotable between an open and a closed position with respect to said housing. | 2010-12-23 |
20100323434 | Compartmentalized Nerve Culture System - The present invention relates generally to a compartmentalized nerve culture system. The compartmentalized nerve culture system has numerous applications including isolation of axons and cell bodies. The present invention has broad application for basic and pre-clinical research including, but not limited to, use in neuroscience, neuronal culture systems, co-culture systems, drug screening, morphological studies, and toxicology studies. | 2010-12-23 |
20100323435 | Injection System for Bio-fuel Reactor - The bio-fuel reactor injection system includes supplementing a biomass feedstock with a feedstock gas so that thermal conditions within the reactor body are optimized. The feedstock gas facilitates the flow of the feedstock through the feedstock injection system and maintains the feedstock below the feedstock's melting point until the feedstock is injected into the reactor body. In the preferred embodiment, the supplemental feedstock gas is nitrogen. The injection system also includes a plurality of screens that form a gas distributor plate. The gas distributor plate at least partially supports a fluidized bed within the reactor body. In the preferred embodiment, the nitrogen-supplemented feedstock is injected into the fluidized bed within the reactor. | 2010-12-23 |
20100323436 | PHOTOBIOREACTOR FOR LARGE-SCALE CULTURE OF MICROALGAL - A photobioreactor for a large-scale microalgal culture. The photobioreactor includes a plurality of surface-light-source assemblies using a light emitting diode (LED) element, an organic light emitting diode (OLED) element, or a flexible LED sheet as a light source. The surface-light-source assemblies have the shape of a flat plate or a cylinder, are installed at predetermined intervals in the interior space of a reaction tank having the shape of a cube or a cylinder, and emit light for culturing microalgae in an internally illuminated fashion. Here, the surface-light-source assemblies are installed in such a manner that they are alternately in contact with first and second walls of the reaction tank disposed in parallel to each other in a symmetrical shape, and serve as partitions that portion the interior space of the reaction tank and increase a flow distance of gas. | 2010-12-23 |
20100323437 | VACUUM BLOOD COLLECTION TUBE - A vacuum blood collection tube ( | 2010-12-23 |
20100323438 | GAS AND LIQUID TISSUE CULTURE INTERFACE - An apparatus and method is described for culturing and conditioning cells on a sample. The apparatus includes a fluid delivery system that transmits gas to a first surface of a sample and transmits liquid to an opposite surface of the sample without transmitting liquid onto the first surface. Further, while culturing cells on the sample, the apparatus enables a constant or variable tension and shear stress applied to the sample. The apparatus may thus, for example, be used to culture cells on an external surface of a tissue construct with air and culture cells underneath the tissue construct with a cell growth media. The fluid delivery system may alternatively transmit liquid cell growth media underneath and on the sides of the tissue construct without flowing onto a designated external surface of the tissue construct. In this manner, cells may be cultured on the tissue construct while stretching and relaxing the tissue and further simulating a dissimilar environment on opposite surfaces of the tissue construct. | 2010-12-23 |
20100323439 | MICROFLUIDIC CELL CULTURE DEVICE - Microfluidic devices for cell culturing and methods for using the same are disclosed. One device includes a substrate and membrane. The substrate includes a reservoir in fluid communication with a passage. A bio-compatible fluid may be added to the reservoir and passage. The reservoir is configured to receive and retain at least a portion of a cell mass. The membrane acts as a barrier to evaporation of the bio-compatible fluid from the passage. A cover fluid may be added to cover the bio-compatible fluid to prevent evaporation of the bio-compatible fluid. | 2010-12-23 |
20100323440 | PROCESS FOR STERILIZING ACELLULAR SOFT TISSUE UNDER PRESSURE - The present invention relates to a process for preparing skin removed from a human donor, removal of cellular components and sterilizing the decellularized skin. The process comprises the following steps:
| 2010-12-23 |
20100323441 | METHOD OF COLLECTION AND PRESERVATION OF FLUIDS AND/OR MATERIALS, IN PARTICULAR OF ORGANIC FLUIDS AND/OR MATERIALS CONTAINING STEM CELLS, AND DEVICE EMPLOYABLE IN SUCH METHOD - A method of collection and preservation of a fluid and/or a material comprises a step of determining a sampling volume that is closed and/or separated from the external environment, a step of taking a predetermined amount of fluid and/or material from the sampling volume and a step of confining the fluid and/or material into a collection volume; the step of taking the fluid and/or material and the step of confining the fluid and/or material are simultaneous with each other and contemporaneous with a step of maintaining the hydraulic and/or pneumatic and/or microbiological isolation between the sampling volume and the collection volume. | 2010-12-23 |
20100323442 | MODULATION OF THE PHOSPHATIDYLINOSITOL-3-KINASE PATHWAY IN THE DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS - Disclosed herein are cell cultures comprising differentiated human cells and methods of producing the same. The present invention provides compositions and methods for the production of differentiated human cells from human pluripotent cells. Preferably, the differentiated cells are selected from the group consisting of mesendoderm cells, definitive endoderm cells, ectoderm cells, trophectoderm cells, and extraembryonic endoderm cells. | 2010-12-23 |
20100323443 | Composition and method for enabling proliferation of pluripotent stem cells - The present disclosure is directed to the development of compositions, such as extracellular matrices, and processes for using the same, that both maintain stem cells in vitro pluripotency and enable self-renewal. In this regard, it has been discovered that when pluripotent mouse and human embryonic stem cells are cultured on plates coated with recombinant laminin-10 (laminin-511) or their functional domains, in the absence of differentiation inhibitors or feeder cells, the embryonic stem cells proliferated and maintained their pluripotency. | 2010-12-23 |
20100323444 | CULTURING AND DIFFERENTIATING NEURAL PRECURSOR CELLS - Systems and methods have been developed for large-scale propagation and differentiation of populations of neurons and glia from neural precursor cells derived from postnatal brain. Under culture conditions containing pituitary extract and mitogenic factors, cells derived from neural stem cells can be attached to a substrate, maintained and serially passaged in culture. Upon removal of mitogenic factors, clusters of neural progenitor cells can be induced that co-express markers of neural stem cells and immature neurons. Unlimited numbers of cells at characterized stages of neurogenesis can be produced. Upon maturation, neuronal cells extend processes and differentiate into mature neuronal phenotypes capable of generating action potentials. | 2010-12-23 |
20100323445 | METHODS, APPARATUS AND SYSTEMS FOR PRODUCTION, COLLECTION, HANDLING, AND IMAGING OF TISSUE SECTIONS - Methods, apparatus and systems for collecting thin tissue samples for imaging. Thin tissue sections may be cut from tissue samples using a microtome-quality knife. In one example, tissue samples are mounted to a substrate that is rotated such that thin tissue sections are acquired via lathing. Collection of thin tissue sections may be facilitated by a conveyor belt. Thin tissue sections may be mounted to a thin substrate (e.g., by adhering thin tissue sections to a thin substrate via a roller mechanism) that may be imaged, for example, by an electron beam (e.g., in an electron microscope). This tissue sections may be strengthened before cutting via a blockface thinfilm deposition technique and/or a blockface taping technique. An automated reel-to-reel imaging technique may be employed for collected/mounted tissue sections to facilitate random-access imaging of tissue sections and maintaining a comprehensive library including a large volume of samples. | 2010-12-23 |
20100323446 | Method of collecting placental cells - Provided herein are improved methods of collecting and recovering placental cells from a mammalian placenta, comprising, e.g., perfusing a mammalian placenta in a closed system such as a sterile bag and folding the placenta at least once during perfusion. Such folding, and perfusion, can be performed mechanically. | 2010-12-23 |
20100323447 | MICROFLUIDIC CELL CULTURE DEVICE AND METHOD FOR USING SAME - Microfluidic devices for cell culturing and methods for using the same are disclosed. One device includes a substrate and membrane. The substrate includes a reservoir in fluid communication with a passage. A bio-compatible fluid may be added to the reservoir and passage. The reservoir is configured to receive and retain at least a portion of a cell mass. The membrane acts as a barrier to evaporation of the bio-compatible fluid from the passage. A cover fluid may be added to cover the bio-compatible fluid to prevent evaporation of the bio-compatible fluid. | 2010-12-23 |
20100323448 | Methods For Producing Biological Substances In Enzyme-Deficient Mutants Of Aspergillus niger - The present invention relates to methods of producing a heterologous biological substance, comprising: (a) cultivating a mutant of a parent | 2010-12-23 |
20100323449 | HIGH THROUGHPUT CATALYTIC PROCESS DEVELOPMENT METHOD - A method for investigating longitudinally dependent properties of the composite catalyst bed of a laboratory scale plug flow reactor, comprises the steps of: supplying fresh reactant feed to the inlet of said composite catalyst bed; sampling and measuring the amounts of fresh reactant feed and amounts and characteristics of reaction products and byproducts at a plurality of positions along the length of said catalyst bed; based on the amounts of fresh reactant feed and amounts and characteristics of reaction products and byproducts at said plurality of positions, determining information concerning longitudinal gradients occurring in the composite catalyst bed of said plug flow reactor. | 2010-12-23 |
20100323450 | SYSTEM FOR QUANTITATIVE MEASUREMENT OF GLYCOHEMOGLOBIN AND METHOD FOR MEASURING GLYCOHEMOGLOBIN - The present invention provides a device for simultaneously detecting hemoglobin and glycohemoglobin in blood, comprising a lateral flow assay strip, a laser-induced epifluorescence detection device, and an LED detection device, and a simple method for simultaneously quantifying hemoglobin and glycohemoglobin in blood by an immunological method using the same. | 2010-12-23 |
20100323451 | METHOD OF PREDICTING PHOSPOLIPIDOSIS INDUCING PROPERTIES OF A SUBSTANCE - The present invention is directed to a method for predicting the risk of a substance exhibiting phospholipidosis inducing properties, the method comprising adding the said substance to an anionic surfactant to form a mixture of said substance and said surfactant, and determining the effect of said substance on the critical micelle concentration (CMC) of the anionic surfactant by determining the CMC of the mixture, whereby a decrease in the CMC as compared to the CMC of the surfactant prior to the addition of the substance is indicative of a risk of said substance exhibiting phospholipidosis inducing properties. | 2010-12-23 |
20100323452 | PROCESS FOR PURIFICATION OF WATER SOLUBLE POLYMERS - A process for purification of water soluble polymers is provided. A polymer of interest can be separated from a mixture of polymers, provided the polymer of interest differs from other polymers in the mixture in the number of reactive terminal groups. The process involves derivatizing polymers at the reactive terminal groups with a derivatizing molecule, bearing either (i) two or three cationic or anionic ionizable groups, and a group capable of covalent bonding to the reactive terminal groups or (ii) three or four ionizable groups, at least one of which is capable of covalent bonding to the reactive terminal groups; followed by ion exchange. The process allows removal of PEG from MPEG, and can be used for polymers having an average size greater than 9,000 Da Derivatization may be reversible in order to allow re-use of recovered contaminant polymers. | 2010-12-23 |
20100323453 | Methods of Using Dyes in Association with Nucleic Acid Staining or Detection and Associated Technology - Methods of using dyes and associated technology are provided. A dye, such as a monomeric dye or a dimeric dye, may be used in a nucleic acid gel staining application and/or a nucleic acid detection application. Such a dye and a salt that comprises an anion that is associated with a strong acid and a cation that is associated with a strong base may be used in such an application. A dimeric dye, such as a dimeric dye capable of forming a hairpin-like structure, may be used to stain and/or detect nucleic acids via a release-on-demand mechanism. A dimeric dye having low background fluorescence in the absence of nucleic acids and high fluorescence in the presence of nucleic acids, upon binding therewith, may be used to stain and/or detect nucleic acids. | 2010-12-23 |
20100323454 | ANALYZING DEVICE, AND ANALYZING APPARATUS AND ANALYZING METHOD USING THE ANALYZING DEVICE - A measurement cell ( | 2010-12-23 |
20100323455 | DIAGNOSTIC ASSAY FOR HUMAN MATRIX GLA-PROTEIN AND ITS USE AS A BIOMARKER - The present invention includes a diagnostic assay for the detection and determination of MGP in a human serum sample, which comprises the use of one or more antibodies, preferably monoclonal antibodies, specifically recognizing epitopes on and/or conformations of human Matrix Gla-Protein. A method is provided for using MGP-related antigens as biomarkers for certain diseases, for example, atherosclerosis and other vascular diseases, and angiogenesis/neogenesis in tumor development. Monoclonal antibodies of class IgG are described for use in the assay, which are defined herein as mAb3-15, mAb35-49[Glu], mAb35-49[Gla], mAb35-53[Glu], and mAb35-53[Gla]. Polyclonal antibodies and methods are also disclosed for measuring MGP in a human serum sample. | 2010-12-23 |
20100323456 | Endothelin Receptors in Morphine Withdrawal - The present invention relates to compositions and methods for managing opioid tolerance and reducing opioid withdrawal. More specifically, the present invention provides for endothelin, endothelin receptors, and endothelin receptor antagonists and agonists as a means for managing G-protein activity in the context of opioid tolerance and withdrawal. | 2010-12-23 |
20100323457 | BIOSENSING METHOD USING COATED MAGNETIC FINE PARTICLES AND BIOSENSING APPARATUS FOR BIOSENSING METHOD - An object of the present invention is to provide a novel biosensing method as the novel application development of the magnetic particles in the biosensing. In an affinity reaction of biosensing, ligands are immobilized to magnetic fine particles and the magnetic fine particles are forced to reaction fields of the affinity reaction by magnetic guiding so as to bring the affinity reaction, which is the velocity controlling factor in the sensing, to high rates. According to the present invention, coated magnetic fine particles with having both of the high dispersion performance and high magnetic responsibility as the above described magnetic fine particles and the affinity reaction occurs quickly and in high density such that the present invention makes it possible to obtain relatively large signals within significantly short time duration when compared to the conventional art. | 2010-12-23 |
20100323458 | METHOD FOR MAKING P(VDF/TrFE) COPOLYMER LAYER SENSORS, AND CORRESPONDING SENSOR - The invention relates to the manufacture of a matrix sensor using a sensitive layer of a ferroelectric P(VDF/TrFE) copolymer, deposited on an integrated circuit. In order to simplify the manufacture and improve the yields, deposited first on the integrated circuit is a first layer of titanium and it is etched in order to form a matrix array of electrodes electrically connected to the integrated circuit; next, a P(VDF/TrFE) copolymer comprising a small proportion of around 1 to 10% of a second polymer that favors the adhesion of the P(VDF/TrFE) copolymer is deposited on the integrated circuit; the polymer is either underneath the P(VDF/TrFE) or blended therewith. The copolymer and its adhesion promoter are etched in a single step, and finally a second conductive layer is deposited and it is etched in order to form a counter electrode for the whole of the matrix array. For use in ultrasonic image sensors. | 2010-12-23 |
20100323459 | METHOD OF AND DEVICE FOR DETERMINING AND CONTROLLING THE DISTANCE BETWEEN AN INTEGRATED CIRCUIT AND A SUBSTRATE - In a method of determining the distance (d) between an integrated circuit ( | 2010-12-23 |
20100323460 | DEFECT INSPECTING METHOD - A defect inspecting method includes: forming, in a first air pressure state, a film, which covers one opening of two openings provided on an upper surface of a substrate, on a tubular contact hole formed on the substrate in manufacturing a semiconductor device and formed in a tubular shape by connecting two cylindrical contact holes on bottom surface sides thereof, both ends of the tubular shape being opened in the openings; exposing the substrate covered with the film in a second air pressure state; and observing whether the film is deformed to thereby inspect whether the part of the tubular shape is blocked. | 2010-12-23 |
20100323461 | Lithographic Method and Arrangement - A method is described for obtaining information for use in modeling of a lithographic process. A pattern feature is formed on a target portion of a substrate by projecting a beam of radiation onto the target portion of the substrate. For that target portion the lithographic process is characterized by one or both of a first property that varies in a first direction along a surface of the substrate, and a second property that varies in a second direction along a surface of the substrate. A property of the pattern feature is measured. Using the measured property of the pattern feature and at least one of the first and second properties, information is obtained for use in modeling the process. The lithographic process may be or include the projection of the beam of radiation onto the surface of the substrate. | 2010-12-23 |
20100323462 | PROCESS ENVIRONMENT VARIATION EVALUATION - Structures and methods are disclosed for evaluating the effect of a process environment variation. A structure and related method are disclosed including a plurality of electrical structures arranged in a non-collinear fashion for determining a magnitude and direction of a process environment variation in the vicinity of the plurality of electrical structures. The plurality of structures may include a first polarity FET coupled to a second polarity FET, each of the first polarity FET and the second polarity FET are coupled to a first pad and a second pad such that the structure allows independent measurement of the first polarity FET and the second polarity FET using only the first and second pads. Alternatively, the electrical structures may include resistors, diodes or ring oscillators. Appropriate measurements of each electrical structure allow a gradient field including a magnitude and direction of the effect of a process environment variation to be determined. | 2010-12-23 |
20100323463 | METHOD FOR MANUFACTURING LIQUID DISCHARGE HEAD - A method for manufacturing a substrate for a liquid discharge head provided with a silicon substrate and a supply port, including: providing the silicon substrate having an insulating layer on a first surface and an etching mask layer having a plurality of apertures on a second surface which is a rear surface of the first surface, wherein the insulating layer is provided in a region ranging from a position opposing the apertures to a position opposing a portion between the adjacent apertures of the mask layer; and forming holes by etching a silicon part of the silicon substrate so that an etched region reaches a portion of the insulating layer opposing the apertures, wherein the silicon wall provided between the adjacent holes is etched so that the portion in the first surface side thereof can be thinner than the portion in the second surface side thereof. | 2010-12-23 |
20100323464 | LIQUID COMPOSITIONS FOR INKJET PRINTING OF ORGANIC LAYERS OR OTHER USES - A method of forming an organic layer for an organic electronic device (e.g., an OLED) by using a liquid composition comprising a small molecule organic semiconductor material mixed in a solvent preparation in which the content of higher boiling impurities is reduced. The solvent preparation comprises a high boiling point solvent and 0.1 wt % or less of impurities having a higher boiling point than the solvent. The liquid composition is deposited on a surface by inkjet printing to form the organic layer. Also, provided are liquid compositions which can be used to make organic layers. | 2010-12-23 |
20100323465 | MOLDED CHIP FABRICATION METHOD AND APPARATUS - A method and apparatus for coating a plurality of semiconductor devices that is particularly adapted to coating LEDs with a coating material containing conversion particles. One method according to the invention comprises providing a mold with a formation cavity. A plurality of semiconductor devices are mounted within the mold formation cavity and a curable coating material is injected or otherwise introduced into the mold to fill the mold formation cavity and at least partially cover the semiconductor devices. The coating material is cured so that the semiconductor devices are at least partially embedded in the cured coating material. The cured coating material with the embedded semiconductor devices is removed from the formation cavity. The semiconductor devices are separated so that each is at least partially covered by a layer of the cured coating material. One embodiment of an apparatus according to the invention for coating a plurality of semiconductor devices comprises a mold housing having a formation cavity arranged to hold semiconductor devices. The formation cavity is also arranged so that a curable coating material can be injected into and fills the formation cavity to at least partially covering the semiconductor devices. | 2010-12-23 |
20100323466 | LIGHT EMITTING DIODE LAMP WITH PHOSPHOR COATED RELECTOR - A light emitting apparatus includes a lamp reflector having phosphor, wherein the lamp reflector further includes an aperture, and an LED light source arranged with the lamp reflector to excite the phosphor and to emit light through the aperture of the lamp reflector. | 2010-12-23 |
20100323467 | FORCE INPUT CONTROL DEVICE AND METHOD OF FABRICATION - Methods of fabricating 3-dimensional force input control devices are disclosed. These roughly comprise: providing a first substrate, fabricating stress-sensitive IC components and signal processing IC on a side one of the first substrate, fabricating one or more closed trenches on a side two of the first substrate within each die area, creating elastic element, frame area and rigid island, providing a second substrate, patterning a side two of the second substrate to define areas for deep etching, creating a layer of bonding material in local areas on at least one of the surfaces of the side one of the second substrate and the side two of the first substrate, aligning and bonding the side two of the first substrate with the side one of the second substrate, etching the second substrate from the side two through to the first substrate, dicing the two bonded substrates into multiple separate dice. | 2010-12-23 |
20100323468 | METHOD OF FABRICATING IMAGE SENSOR PHOTODIODES USING A MULTI-LAYER SUBSTRATE AND CONTACT METHOD AND THE STRUCTURE THEREOF - The present invention relates to a photodiode of an image sensor using a three-dimensional multi-layer substrate, and more particularly, to a method of implementing a buried type photodiode and a structure thereof, and a trench contact method for connecting a photodiode in a multi-layer substrate and a transistor for signal detection. | 2010-12-23 |
20100323469 | METHODS FOR SEPARATING INDIVIDUAL SEMICONDUCTOR DEVICES FROM A CARRIER - A wafer of integrated circuits may be bonded to a carrier wafer using a layer of bonding material. The thickness of the wafer of integrated circuits may then be reduced using a series of grinding operations. After grinding, backside processing operations may be performed to form scribe channels that separate the die from each other and to form through-wafer vias. The scribe channels may be formed by dry etching and may have rectangular shapes, circular shapes, or other shapes. A pick and place tool may have a heated head. The bonding layer material may be based on a thermoplastic or other material that can be released by application of heat by the heated head of the pick and place tool. The pick and place tool may individually debond each of the integrated circuits from the carrier wafer and may mount the debonded circuits in packages. | 2010-12-23 |
20100323470 | BACKSIDE ILLUMINATED IMAGE SENSOR HAVING DEEP LIGHT REFLECTIVE TRENCHES - An array of pixels is formed using a semiconductor layer having a frontside and a backside through which incident light is received. Each pixel typically includes a photosensitive region formed in the semiconductor layer and a trench formed adjacent to the photosensitive region. The trench causes the incident light to be directed away from the trench and towards the photosensitive region. | 2010-12-23 |
20100323471 | Selective Etch of Laser Scribed Solar Cell Substrate - Methods for making solar cells are described. The methods include selectively etching strips formed by laser scribing to remove oxides formed during laser scribing. | 2010-12-23 |
20100323472 | METHOD FOR THE PRODUCTION OF THIN SUBSTRATES - A method is provided for producing a thin substrate with a thickness below 750 microns, comprising providing a mother substrate, the mother substrate having a first main surface and a toughness; inducing a stress with predetermined stress profile in at least a portion of the mother substrate, said portion comprising the thin substrate, the induced stress being locally larger than the toughness of the mother substrate at a first depth under the main surface; such that the thin substrate is released from the mother substrate, wherein the toughness of the mother substrate at the first depth is not lowered prior to inducing the stress. The method can be used in the production of, for example, solar cells. | 2010-12-23 |
20100323473 | METHOD OF FORMING ORGANIC SEMICONDUCTOR LAYER AND METHOD OF MANUFACTURING ORGANIC THIN FILM TRANSISTOR - Disclosed is a method of forming an organic semiconductor layer comprising the steps of preparing a substrate having a groove formed on the surface, applying, to the surface of the substrate, a droplet of an organic semiconductor liquid in which an organic semiconductor material is dissolved or dispersed in a solvent, and drying the droplet to form the organic semiconductor layer, wherein the droplet is applied to a position of the substrate where a part of the circumference of the droplet is introduced into the groove. | 2010-12-23 |
20100323474 | METHOD OF MANUFACTURING SEMICONDUCTOR PACKAGE AND METHOD OF MANUFACTURING SUBSTRATE FOR THE SEMICONDUCTOR PACKAGE - A method of manufacturing a semiconductor package, includes the steps of: forming a substrate on which a semiconductor chip is to be mounted; and mounting the semiconductor chip on the substrate through connection bumps, the substrate forming step including a first step of forming a plurality of electrode pads to be bonded to the connection bumps on a part of a support plate, a second step of forming one or more wiring layers on the support plate including the electrode pads with an insulation layer interposed between them, thereby forming a substrate having the electrode pads formed thereon on one side thereof, and a third step of removing the substrate from the support plate, wherein a plurality of first convex portions are formed on the support plate prior to the first step, and the electrode pads are formed on the first convex portions at the first step. | 2010-12-23 |
20100323475 | Integrated circuit device - An integrally packaged optronic integrated circuit device ( | 2010-12-23 |
20100323476 | ULTRASONIC BONDING EQUIPMENT FOR MANUFACTURING SEMICONDUCTOR DEVICE, SEMICONDUCTOR DEVICE AND ITS MANUFACTURING METHOD - An ultrasonic bonding equipment for manufacturing a semiconductor device comprises a tip portion. The tip portion has a top surface which is faced to a member to be bonded, and propagates an ultrasonic vibration to the top surface. A plurality of protruding portions are provided on the top surface. Each of the protruding portions has: a first pair of opposite side surfaces inclined with respect to the top surface; and a second pair of opposite side surfaces substantially vertical to the top surface. A semiconductor device comprises: a semiconductor chip; a lead; and a bonding strap electrically connecting the semiconductor chip and the lead. A recess is formed on an upper surface of the bonding strap in at least one of a first region where the bonding strap and the semiconductor chip are connected and a second region where the bonding strap and the lead is connected. A first pair of opposite side surfaces of the recess are inclined with respect to the upper surface of the bonding strap, and a second pair of opposite side surfaces of the recess are substantially vertical to the upper surface of the bonding strap. | 2010-12-23 |
20100323477 | INTERCONNECTIONS OF AN INTEGRATED ELECTRONIC CIRCUIT - A method to fabricate an integrated electronic circuit includes superimposing insulating layers and metal elements distributed within said insulating layers. Each insulating layer comprises a first level within which the metal elements lie substantially in the plane of the first level, and a second level traversed by the metal elements in a direction substantially perpendicular to the plane of the second level, so as to come into contact with at least one metal element of the first level. The levels also comprise insulation zones for insulating the metal elements from each other. In one insulating layer, at least one of the levels comprises at least two insulation zones respectively realized of a first material and a second material which are different from each other. | 2010-12-23 |
20100323478 | METHOD FOR FABRICATING THROUGH-SILICON VIA STRUCTURE - A method for fabricating through-silicon via structure is disclosed. The method includes the steps of: providing a semiconductor substrate; forming at least one semiconductor device on surface of the semiconductor substrate; forming a dielectric layer on the semiconductor device, in which the dielectric layer includes at least one via hole; forming a first conductive layer on the dielectric layer and filling the via hole; performing an etching process to form a through-silicon via in the first conductive layer, the dielectric layer, and the semiconductor substrate; depositing a second conductive layer in the through-silicon via and partially on the first conductive layer; and planarizing a portion of the second conductive layer until reaching the surface of the first conductive layer. | 2010-12-23 |
20100323479 | Semiconductor Component with Surface Mountable Devices and Method for Producing the Same - A semiconductor component including: a substrate, at least one semiconductor chip arranged on the substrate and at least one passive device likewise arranged on the substrate. The passive device is mounted with its underside on the substrate. The semiconductor component further includes an interspace disposed between the underside of the passive device and the substrate. The interspace is filled with an underfilling material. In order to avoid the solder pumping effect, the upper side and the lateral sides of the passive device are also embedded in a plastic compound. | 2010-12-23 |
20100323480 | MULTIPLE SELECT GATES WITH NON-VOLATILE MEMORY CELLS - Multiple select gates in association with non-volatile memory cells are described. Various embodiments include multiple select gate structure, process, and operation and their applicability for memory devices, modules, and systems. In one embodiment a memory array is described. The memory array includes a number of select gates coupled in series to a number of non-volatile memory cells. A first select gate includes a control gate and a floating gate electrically connected together and a second select gate includes a control gate and a floating gate which are electrically separated by a dielectric layer. | 2010-12-23 |
20100323481 | SYSTEMS AND DEVICES INCLUDING MULTI-GATE TRANSISTORS AND METHODS OF USING, MAKING, AND OPERATING THE SAME - Disclosed are methods of forming transistors. In one embodiment, the transistors are formed by forming a plurality of elliptical bases in a substrate and forming fins form the elliptical bases. The transistors are formed within the fin such that they may be used as access devices in a memory array. | 2010-12-23 |
20100323482 | TFT ARRAY SUBSTRATE AND THE FABRICATION METHOD THEREOF - A TFT array substrate is provided. The TFT array substrate includes: a gate electrode connected to a gate line; a source electrode connected to a data line that crosses the gate line and defines a pixel region; a drain electrode facing the source electrode with a channel between; a semiconductor layer forming the channel in between the source electrode and the drain electrode; a pixel electrode in the pixel region and contacting the drain electrode; a channel passivation layer formed on the semiconductor layer; a gate pad with a gate pad lower electrode that extends from the gate line; and a data pad having a data pad lower electrode separated from the data line. | 2010-12-23 |
20100323483 | METHOD OF FABRICATING MEMORY - A method of fabricating a semiconductor device is provided. First, a stacked structure is formed on a substrate. The stacked structure includes, from the substrate, a dielectric layer and a conductive gate in order. An ion implant process is performed to form doped regions in the substrate on the opposite sides of the stacked structure. Thereafter, source-side spacer is formed on a sidewall of the stacked structure. A thermal process is performed to activate the doped regions, thereby forming a source in the substrate under the sidewall of the stacked structure having the source-side spacer and a drain in the substrate on another side of the stacked structure. | 2010-12-23 |
20100323484 | METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE - A method of manufacturing a semiconductor device may include, but is not limited to the following processes. First and second gate electrodes are formed over a semiconductor substrate. An epitaxial layer is selectively formed over the semiconductor substrate. The epitaxial layer is adjacent to the first gate electrode. A first impurity is introduced into the semiconductor substrate through the epitaxial layer to form a first impurity region and directly into the semiconductor substrate to form a second impurity region. The first and second impurity regions are adjacent to the first and second gate electrodes, respectively. The first impurity region includes the epitaxial layer. A first bottom surface of the first impurity region is shallower in level than a second bottom surface of the second impurity region. | 2010-12-23 |
20100323485 | PN JUNCTION AND MOS CAPACITOR HYBRID RESURF TRANSISTOR - A high voltage semiconductor device, such as a RESURF transistor, having improved properties, including reduced on state resistance. The device includes a semiconductor substrate with a drift region between source region and drain regions. The drift region includes a structure having a spaced trench capacitor extending between the source region and the drain region and a vertical stack extending between the source region and the drain region. When the device is in an on state, current flows between the source and drain regions; and, when the device is in an off/blocking state, the drift region is depleted into the stack. | 2010-12-23 |
20100323486 | TRIPLE-GATE TRANSISTOR WITH REVERSE SHALLOW TRENCH ISOLATION - Example embodiments provide triple-gate semiconductor devices isolated by reverse shallow trench isolation (STI) structures and methods for their manufacture. In an example process, stacked layers including a form layer over a dielectric layer can be formed over a semiconductor substrate. One or more trenches can be formed by etching through the stacked layers. The one or more trenches can be filled by an active area material to form one or more active areas, which can be isolated by remaining portions of the dielectric layer. Bodies of the active area material can be exposed by removing the form layer. One or more triple-gate devices can then be formed on the exposed active area material. The example triple-gate semiconductor devices can control the dimensions for the active areas and provide less isolation spacing between the active areas, which optimizes manufacturing efficiency and device integration quality. | 2010-12-23 |
20100323487 | RADIATION HARDENED DEVICE - A “tabbed” MOS device provides radiation hardness while supporting reduced gate width requirements. The “tabbed” MOS device also utilizes a body tie ring, which reduces field threshold leakage. In one implementation the “tabbed” MOS device is designed such that a width of the tab is based on at least a channel length of the MOS device such that a radiation-induced parasitic conduction path between the source and drain region of the device has a resistance that is higher than the device channel resistance. | 2010-12-23 |
20100323488 | Semiconductor device and method of manufacturing the same - Provided is a semiconductor device including: a silicon substrate; at least two trenches spaced apart from each other, being in parallel with each other, and being formed by vertically etching the silicon substrate from a surface thereof; an electrically insulating film for burying therein at least bottom surfaces of the trenches; a base region formed in a region of the silicon substrate located between the two trenches; and an emitter region and a collector region formed on portions of side surfaces of the trenches, respectively, the portions of the sides located above the insulating film and formed in the base region. | 2010-12-23 |
20100323489 | Method of forming a vertical diode and method of manufacturing a semiconductor device using the same - A method of forming a vertical diode and a method of manufacturing a semiconductor device (e.g., a semiconductor memory device such as a phase-change memory device) includes forming an insulating structure having an opening on a substrate and filling the opening with an amorphous silicon layer. A metal silicide layer is formed to contact at least a portion of the amorphous silicon layer and a polysilicon layer is then formed in the opening by crystallizing the amorphous silicon layer using the metal silicide layer. A doped polysilicon layer is formed by implanting impurities into the polysilicon layer. Thus, the polysilicon layer is formed in the opening without performing a selective epitaxial growth (SEG) process, so that electrical characteristics of the diode may be improved. | 2010-12-23 |
20100323490 | Self-Aligned Cross-Point Memory Fabrication - Fabricating a cross-point memory structure using two lithography steps with a top conductor and connector or memory element and a bottom conductor orthogonal to the top connector. A first lithography step followed by a series of depositions and etching steps patterns a first channel having a bottom conductor. A second lithography step followed by a series of depositions and etching steps patterns a second channel orthogonal to the first channel and having a memory element connecting the an upper conductor and the lower conductor at their overlaid intersections. | 2010-12-23 |
20100323491 | SEMICONDUCTOR DEVICE AND METHOD OF MANUFACTURING THE SAME - Any of a plurality of contact plugs which reaches a diffusion layer serving as a drain layer of an MOS transistor has an end provided in contact with a lower surface of a thin insulating film provided selectively on an interlayer insulating film. A phase change film constituted by GST to be a chalcogenide compound based phase change material is provided on the thin insulating film, and an upper electrode is provided thereon. Any of the plurality of contact plugs which reaches the diffusion layer serving as a source layer has an end connected directly to an end of a contact plug penetrating an interlayer insulating film. | 2010-12-23 |
20100323492 | Methods of manufacturing phase-change random access memory devices - A PRAM device includes a lower electrode, a phase-change nanowire and an upper electrode. The phase-change nanowire may be electrically connected to the lower electrode and includes a single element. The upper electrode may be electrically connected to the phase-change nanowires. | 2010-12-23 |
20100323493 | Method for Fabricating an Integrated Circuit Including Resistivity Changing Material Having a Planarized Surface - An integrated circuit is fabricated by providing a preprocessed wafer including a first electrode, depositing a dielectric material over the preprocessed wafer, etching an opening in the dielectric material to expose a portion of the first electrode and depositing a first resistivity changing material over exposed portions of the etched dielectric material and the first electrode. The first resistivity changing material is planarized to expose the etched dielectric material. A second resistivity changing material is deposited over the etched dielectric material and the first resistivity changing material, and an electrode material is deposited over the second resistivity changing material. | 2010-12-23 |
20100323494 | NARROW CHANNEL WIDTH EFFECT MODIFICATION IN A SHALLOW TRENCH ISOLATION DEVICE - A method of manufacturing a semiconductor structure is provided. The method includes forming a hard mask pattern on a semiconductor substrate, wherein the hard mask pattern covers active regions; forming a trench in the semiconductor substrate within an opening defined by the hard mask pattern; filling the trench with a dielectric material, resulting in a trench isolation feature; performing an ion implantation to the trench isolation feature using the hard mask pattern to protect active regions of the semiconductor substrate; and removing the hard mask pattern after the performing of the ion implantation. | 2010-12-23 |
20100323495 | RECESSED GATE ELECTRODE MOS TRANSISTOR AND METHOD FOR FABRICATING THE SAME - Disclosed are a transistor and a method for fabricating the same capable of increasing a threshold voltage and a driving current of the transistor. The method includes the steps of forming a first etch mask on a silicon substrate, forming a trench by etching the exposed isolation area, forming a first insulation layer in the trench and the first etch mask, forming a second insulation layer on the first insulation layer, removing the second insulation layer and the first insulation layer until the first etch mask is exposed, forming a trench type isolation layer on the isolation area, forming a second etch mask on an entire surface of the silicon substrate, etching the exposed channel area, performing an etching process with respect to a resultant substrate structure, and forming a gate in the recess. | 2010-12-23 |
20100323496 | PROCESS FOR MANUFACTURING A COMPOSITE SUBSTRATE - The invention relates to a process for manufacturing a composite substrate comprising bonding a first substrate ( | 2010-12-23 |
20100323497 | METHOD OF TRANSFERRING A THIN LAYER ONTO A TARGET SUBSTRATE HAVING A COEFFICIENT OF THERMAL EXPANSION DIFFERENT FROM THAT OF THE THIN LAYER - A method of transferring a thin layer from a source substrate having a surface layer of a first material along a free surface thereof to a target substrate having at least one surface layer of a second material along a free surface thereof, where the first material differs from the second material, includes forming within the surface layer of the source substrate a weakened zone delimiting a thin layer with respect to the free surface, and assembling the free surface of the source substrate to the free surface of the target substrate in a stack of alternating layers comprising the first and second materials, so that there are, on either side of an interface formed by bringing the free surfaces into intimate contact. The cumulative thicknesses of the layers of the first material are substantially equal to the cumulative thickness of the layers of the second material, the layers having thicknesses at least equal to 50 microns and at least 1000 times the depth at which the weakened zone is formed. The thin layer is detached by applying at least partially thermal energy to fracture the weakened zone. | 2010-12-23 |
20100323498 | Circuit Device and Method of Manufacturing Thereof - A circuit device of preferred embodiments of the present invention includes: a circuit element with electrodes formed in a peripheral part thereof; connecting portions connected to surfaces of the electrodes; and redistribution lines which are continuous to the respective connecting portions and extended in parallel to the main surface of the circuit element. In preferred embodiments of the present invention, the connecting portions and the redistribution lines are integrally formed of one piece of metal. Accordingly, there is no place where different materials are connected in a portion between the connecting portions and the redistribution lines, thus improving a joint reliability of the entire device against a thermal stress or the like. | 2010-12-23 |