51st week of 2010 patent applcation highlights part 43 |
Patent application number | Title | Published |
20100323299 | PROJECTION OBJECTIVE FOR IMMERSION LITHOGRAPHY - A projection objective suitable for immersion microlithography is designed as a single-waist system with five lens groups, and has a first lens group of negative refractive power, a second lens group of positive refractive power, a third lens group of negative refractive power, a fourth lens group of positive refractive power and a fifth lens group of positive refractive power. The fourth lens group has an entrance surface (E) that lies in the vicinity of a point of inflection of a marginal ray height between the third lens group (LG | 2010-12-23 |
20100323300 | DIGITAL OPTICAL CHEMISTRY MICROMIRROR IMAGER - An apparatus and method for catalyzing a reaction on a substrate ( | 2010-12-23 |
20100323301 | Method and apparatus for making three-dimensional parts - Method and apparatus for fabricating 3D parts with slurry are disclosed. The slurry comprises at least a polymer, an organic binder and a solvent. The process comprises paving the slurry to form a sacrificial layer which is then dried to a solid state. The sacrificial layer is soaked in a developer for being disintegrated. After being irradiated with energy beam, the sacrificial layer is transformed into a part layer which does not dissolve in developer. By repeating the above steps, a preliminary 3D part surrounded by a sacrificial portion constituted of a plurality of sacrificial layers without being irradiated is obtained. The resultant 3D part is obtained by separating the sacrificial portion from the preliminary 3D part. By processing inorganic component of the 3D semi-product with high temperature densification sintering step, a final 3D part consisting of ceramic, metal or ceramic-metal composite with a high strength is obtained. | 2010-12-23 |
20100323302 | PROTECTIVE APPARATUS, MASK, MASK FABRICATING METHOD AND CONVEYING APPARATUS, AND EXPOSURE APPARATUS - A protective apparatus that protects a predetermined area of the front surface of a mask substrate, provided with a pellicle frame that is disposed on at least a portion of the circumference of the predetermined area and bonded to the front surface of the mask substrate, and a pellicle that is mounted on the pellicle frame so as to cover an opening portion that is formed by the pellicle frame in a manner facing the predetermined area; in which the pellicle frame includes a first side portion and a second side portion, and a third side portion and a fourth side portion that are disposed at different positions along the predetermined area, and in relation to the normal direction of the front surface of the mask substrate, the rigidity of the first side portion and the second side portion is lower than the rigidity of the third side portion and the fourth side portion. | 2010-12-23 |
20100323303 | LIQUID IMMERSION MEMBER, EXPOSURE APPARATUS, EXPOSING METHOD, AND DEVICE FABRICATING METHOD - An exposure apparatus including: an optical system, which has an emergent surface; a first surface, which is disposed at least partly around an optical path of exposure light from the emergent surface; a second surface, which is disposed at least partly around the first surface; a third surface, which is disposed at least partly around the second surface; a first supply port, which is disposed at least partly around the first surface such that the first supply port is directed in an outward radial direction with respect to an optical axis of the optical system, that supplies a first liquid to the second surface; and a second supply port, which is disposed at least partly around the second surface such that the second supply port is directed in an outward radial direction with respect to the optical axis, that supplies a second liquid to the third surface. | 2010-12-23 |
20100323304 | INSPECTION METHOD FOR PATTERNING OF PHOTORESIST - A nozzle is moved while supplying a photoresist liquid from a slit. A photoresist layer is formed on a film. A resist pattern which covers a portion of the film is formed from the photoresist layer by photolithography. Inspection of the resist pattern is performed. The photolithography includes an exposure which is performed so as to transfer a latent image to the photoresist layer, and a development of the photoresist layer which is performed so as to leave the latent image. The latent image contains a dummy latent image which extends in an unbroken manner parallel to the longitudinal direction of the slit. The resist pattern contains a dummy resist formed correspondingly to the dummy latent image. The inspection of the resist pattern includes the detection of the presence or non-presence of a cut in the dummy resist in the longitudinal direction. | 2010-12-23 |
20100323305 | PATTERN FORMING METHOD, RESIST COMPOSITION FOR MULTIPLE DEVELOPMENT USED IN THE PATTERN FORMING METHOD, DEVELOPER FOR NEGATIVE DEVELOPMENT USED IN THE PATTERN FORMING METHOD, AND RINSING SOLUTION FOR NEGATIVE DEVELOPMENT USED IN THE PATTERN FORMING METHOD - A pattern forming method, including: (A) coating a substrate with a positive resist composition of which solubility in a positive developer increases and solubility in a negative developer decreases upon irradiation with actinic rays or radiation, so as to form a resist film; (B) exposing the resist film; and (D) developing the resist film with a negative developer; a positive resist composition for multiple development used in the method; a developer for use in the method; and a rinsing solution for negative development used in the method. | 2010-12-23 |
20100323306 | SUBSTRATE TREATMENT SYSTEM, SUBSTRATE TREATMENT METHOD, AND COMPUTER READABLE STORAGE MEDIUM - In the present invention, a plurality of heat treatment plates are provided side by side in a linear form on a base of a heat treatment apparatus in a coating and developing treatment system. In the heat treatment apparatus, three transfer member groups are provided which transfer a substrate in zones between adjacent heat treatment plates. At the time when performing a pre-baking treatment in the heat treatment apparatus, the substrate is transferred in order to the heat treatment plates at the same temperature, whereby the heat treatment is dividedly performed on the heat treatment plates. According to the present invention, substrates are subjected to heat treatment along the same route, so that the thermal histories are made uniform among the substrates. | 2010-12-23 |
20100323307 | DEVELOPING APPARATUS AND METHOD - A developing apparatus for developing a substrate whose surface is coated with a coating solution and then exposed includes a substrate supporting unit for horizontally supporting the substrate, a rotation driving mechanism for rotating the substrate supporting unit forwardly or backwardly with respect to a vertical axis, a developer nozzle, disposed to face a surface of the substrate supported by the substrate supporting unit, having a strip-shaped injection opening extended along a direction extending from a periphery of the substrate toward a central portion thereof, a moving unit for moving the developer nozzle from an outer portion of the substrate toward the central portion thereof, and a controller for controlling operations such that while the substrate is rotated forwardly by the rotation driving mechanism, a developer is supplied through the injection opening to the surface of the substrate by moving the developer nozzle and, then, the substrate is rotated backwardly by the rotation driving mechanism. | 2010-12-23 |
20100323308 | SORBENTS FOR COAL COMBUSTION - Sorbent compositions containing halogen and calcium are added to coal to mitigate the release of sulfur and/or other harmful elements, including mercury, into the environment during combustion of coal containing natural levels of mercury. | 2010-12-23 |
20100323309 | Burner and Method for Reducing Self-Induced Flame Oscillations - A method for reducing self-induced flame oscillations is provided. In a first fluid mass flow flowing through a jet nozzle from a fluid inlet opening to a fluid outlet opening, a second fluid mass flow is injected on an axial position of the jet nozzle positioned downstream from the fluid inlet opening. One fluid mass flow includes air, and the other fluid mass flow includes a fuel. A second method for reducing self-induced flame oscillations is also provided. In a first fluid mass flow flowing through a jet nozzle from a fluid inlet opening to a fluid outlet opening, a second fluid mass flow is injected on a radial position of the jet nozzle in relation to the circumference of the jet nozzle. One mass flow includes air and the other fluid mass flow includes a fuel. Burners which ensure the execution of the method are also provided. | 2010-12-23 |
20100323310 | Method for mechanical stoking in firing installations and firing installation - A method for mechanical stoking in firing installations and a firing installation is provided. Fuel is applied to a grate using a mechanical stoker, the grate being disposed in a firing chamber, wherein the mechanical stoker is oriented opposite a delivery direction of the grate. The fuel is introduced directly below a firing chamber ceiling, viewed in the delivery direction of the grate before the end of the grate such that a burnout zone, which does not have fresh fuel applied thereto, is created on the grate between the mechanical stoker and the end of the grate. | 2010-12-23 |
20100323311 | BURNER FOR MANUFACTURING POROUS GLASS BASE MATERIAL - The present invention provides a burner for manufacturing a porous glass base material that has small-diameter gas discharge ports and that achieves uniform linear velocity at the gas discharge ports, a uniform reaction, and a stable flame, and improved deposition efficiency. In the burner for manufacturing a porous glass base material, inner diameters of the pipes forming the gas discharge ports positioned farther inward in a radial direction than the gas discharge ports in which the small-diameter gas discharge port nozzles are arranged contract beginning from a position farther on a burner source side than the prescribed length L position, the contraction being greater closer to a burner tip side, and inner diameters of the pipes forming the gas discharge port in which the small-diameter gas discharge port nozzles are arranged and the gas discharge ports that are positioned farther outward in the radial direction than this gas discharge port contract beginning from a position farther on a burner tip side than the prescribed length L position, the contraction being greater closer to a burner tip side. | 2010-12-23 |
20100323312 | ELECTRICALLY OPERATED GAS/OIL BURNER - The invention is an electrically operated gas/oil burner which is the improved version of “Electronically Igniting Fuel Oil Burner” documented before Turkish Patent Institute with number of TR 2007 01880 U, and before French and German Patent Offices abroad. Its specification is to burn gas/oil, and to provide efficient burning (blue burning) by atomizing fuel oil. | 2010-12-23 |
20100323313 | STAGE STRUCTURE AND HEAT TREATMENT APPARATUS - There is provided a stage structure which can prevent the formation of a cool spot in the central portion of a stage, thereby preventing breakage of the stage, and can enhance the in-plane uniformity of heat treatment of a processing object. | 2010-12-23 |
20100323314 | Hot Air Stove - The inventive air heater comprises a housing ( | 2010-12-23 |
20100323315 | Orthodontic bracket - An orthodontic bracket is provided for correcting teeth alignment. The orthodontic bracket allows for not relying on how an operator is skilled in ligation and also for minimizing the friction. The orthodontic bracket includes a slot having an opening into which an orthodontic wire can be inserted, and a shutter that can slide to block or unblock the opening. The orthodontic wire is placed in the slot by causing the shutter to slide and unblock the opening, inserting the wire through the opening, and causing the shutter to slide and block the opening. The orthodontic wire will not disengage from the slot, whereby rotation control, tipping control, and torque control may be reliably performed. Further, it is not necessary to perform ligation that causes the wire to be securely pressed against the bottom of the slot. Since the ligation is not tight, the tooth in question can be smoothly shifted. | 2010-12-23 |
20100323316 | Safety Attachment for Orthodontic Wires and Pliers to Apply Attachment - A safety attachment (A; B; C; D; E; F) is specifically designed for application to orthodontic wire ( | 2010-12-23 |
20100323317 | ORTHODONTIC TREATMENT METHODS, SYSTEMS AND APPARATUS FOR USE THEREWITH - Systems, methods, and apparatus for creating a mold of a patient's teeth to which are installed orthodontic appliances with a support assembly bonded to a tooth. The appliances may include a corresponding corrective assembly with a wire engaging portion removably coupled to the support assembly. The systems and methods may include removing a corrective assembly from a support assembly, applying unset molding compound to the patient's teeth and corresponding support assemblies, setting the molding compound into a mold, and nondeformably removing the mold from the patient's mouth. The support assemblies may include a marker portion to indicate the position of the wire engaging portion of a corrective assembly that may be removed prior to making a mold and/or installed after making the mold. Marker assemblies adapted to removably engage a support assembly, and including such a marker portion, may be temporarily coupled to support assemblies prior to making a mold. | 2010-12-23 |
20100323318 | Laser Handpiece - A laser handpiece, which has an outer guide sleeve in which a light guide is contained, is provided with a releasable clamping device. By the rotation of a rotary ring on the guide sleeve, the clamping device can be released and an advancing of the light guide, either manually or automatically, can be guaranteed. | 2010-12-23 |
20100323319 | DENTAL APPARATUS - The present invention provides a dental apparatus ( | 2010-12-23 |
20100323320 | SURGICAL GUIDE AND A METHOD FOR POSITIONING A DRILL USING THE SURGICAL GUIDE - Provided is a surgical guide that enables a dentist to visually identify the tip of a drill during dental implant treatment, and does not allow the drill to tilt more than necessary, and enables sufficient cooling water to be provided so as not to cause bone burns, and is compatible with several different types of drills having different diameters. A first wire is embedded in a mockup in a same orientation as the orientation of a fixture of an implant is to be embedded. A guide member of a surgical guide is fitted to a tooth portion of the mockup. An adjusting mechanism adjusts such that an intersection line made by plane-shaped red laser light beam and green laser light beam from line laser modules is located on the first wire. The guide member is removed from the tooth portion of the mockup, and fitted to a tooth portion in the mouth, and the orientation of a drill is aligned with the intersection line. Drilling operation is performed in the aligned condition. | 2010-12-23 |
20100323321 | PORTABLE TEETH-CLEANSING AND PURGING DEVICE - A portable teeth-cleansing and purging device is disclosed. The device comprises a manual-operated pump, and a ejecting tube module. The manual-operated pump is a reciprocating pump which possesses a body and a pressing rod. The body is in communication externally with a suction tube having a water outlet. The ejecting tube module is a resilient tube having the ends mounted with a connector head and a purging head. The connector head is connected to the outer surrounding of the water outlet, and the purging head is a hollow tubing element. The end of the water outlet is a nozzle. By pressing and releasing of the pressing rod, the manual-operated pump is triggered to deliver a fixed amount of water supply via the water outlet, and as a result of restriction by the nozzle, a pressurized water stream for cleansing the gaps between the teeth is obtained. The device mitigates the requirement of current supply and water source in cleansing teeth. The device is portable and simple in structure. | 2010-12-23 |
20100323322 | Syringe-in-Syringe Hollow Inner Barrel/Plunger With Integral Seal and Rupturable Membrane and Related Kits, Systems and Methods - A hollow inner plunger ( | 2010-12-23 |
20100323323 | Pliable gingival isolation material - A gingival isolation material that is pliable once cured or set. The isolation material can include components such as water, a thickening agent, a plasticizer, a dye and a preservative. | 2010-12-23 |
20100323324 | Blocking Having Joining Structure of Dental Implant Abutment and Upper Structure and Manufacturing Method of the Same - Disclosed are a block having a structure for joining an abutment and a superstructure for a dental implant and a method for manufacturing the same. An abutment and a superstructure are not shaped in advance, and instead, a block, in which a structure for joining a fixture and other connection parts of a dental prosthesis are formed, is manufactured such that the block can be machined through CAD/CAM, or, after a wax mock-up or a resin mock-up is scanned and drawn on a paper, the block can be machined through CAM to form an abutment or the crown of a superstructure. In order to provide high strength and high toughness, the block is made of a stabilized tetragonal zirconia polycrystalline (TZP)-based material or a composite of zirconia and oxide. The method comprises the steps of pressing a starting material for a block, machining a resultant formation, and sintering the machined formation. | 2010-12-23 |
20100323325 | METHOD AND SYSTEM FOR FIXING REMOVABLE DENTURES - A removable denture system comprising a support beam fixedly attached to the individual's alveolar ridge above the mucous membrane by a plurality of dental implants, and a denture generally conforming with the dental parameters of the individual and integrated with a supper-structure. The supper-structure comprises at least a portion shaped in confirmation with the support beam, and a denture locking arrangement for removably though fixedly articulating the denture to the support beam preventing unintentional disengagement of the denture. | 2010-12-23 |
20100323326 | Dental Implant with Interlocking and Centering Threads - A dental implant device for insertion into a bore defined in bone for use with a prosthetic tooth or dental appliance includes an abutment with a plurality of male keys disposed about the distal end of the abutment capable of being affixed to the prosthetic tooth or dental appliance, an implantable anchor having a proximal and distal end, a plurality of female keyways defined into the proximal end of the anchor, the keyways capable of coupling to the male keys of the abutment and thereby preventing relative rotation of the abutment and anchor; an interlocking thread helically defined around a longitudinal axis of the anchor, the thread being adapted to couple to the bore defined in the bone and means for coupling the abutment to the implant anchor. | 2010-12-23 |
20100323327 | METHOD OF PRODUCING A DENTAL PRODUCT - Methods of producing a dental product are disclosed. Certain methods include the steps of providing a pre-sintered blank made from a green body of ceramic material, performing a machining operation on the blank, and subsequently sintering the blank to its final density in a sintering operation performed at a temperature in the range of 1300° C. to 1650° C. The pre-sintered blank that is provided may have a strength in the range of 53 -107 MPa. | 2010-12-23 |
20100323328 | DENTAL RESTORATIONS USING NANOCRYSTALLINE MATERIALS - Dental articles are produced using relatively low sintering temperatures to achieve high density dental articles exhibiting strengths equal to and greater than about 700 MPa. Ceramic powders comprised of nanoparticulate crystallites are used to manufacture dental articles. The ceramic powders may include sintering agents, binders and other similar additives to aid in the processing of the ceramic powder into a dental article. The ceramic powders may be processed into dental articles using various methods including, but not limited to, injection molding, gel-casting, slip casting, or electroforming, hand, cad/camming and other various rapid prototyping methods. The ceramic powder may be formed into a suspension, pellet, feedstock material or a pre-sintered blank prior to forming into the dental article. | 2010-12-23 |
20100323329 | Apparatus and Method for Manufacturing Customized Dentures - This disclosure relates to an apparatus and method for digitally utilizing and customizing dental features needed in the manufacture of dentures. | 2010-12-23 |
20100323330 | Tooth Colorant and Whitener, Method of Manufacture, and Method of Use Thereof - A polymerizable tooth colorant composition, comprising: a polymerizable resin composition; an additive composition comprising a colorant, a whitener, or both; and a curing system. The composition allows easy coloring and/or whitening of teeth. | 2010-12-23 |
20100323331 | GEAR SHIFTING MECHANISM - The subject matter described herein is directed to gear shifting and in particular is related to the field of simulation of gear shifting in a vehicle. The present subject matter proposes a strategic solution to eliminate the challenges experienced in the simulation of conventional gear shifting. | 2010-12-23 |
20100323332 | Method and Apparatus for Improving Language Communication - In a communication between individuals having different levels of skill in a language, communication by the more skilled individual is controlled so as to keep it at a level understandable by the lesser skilled individual. For example, a native speaker's communication with a student learning his language (the target language) is monitored by an interface and compared with a stored model representing the student's knowledge and ability in the language. Should the native speaker communicate in a way that would not be understood by the student, for example, by using vocabulary or a sentence structure beyond the student's ability, the interface will notify the native speaker. The interface might then suggest an alternate word or sentence structure to the native speaker, inviting him to use the alternate communication. The native speaker can then substitute and send the alternate communication. | 2010-12-23 |
20100323333 | METHOD AND APPARATUS FOR RANDOMLY PROVIDING LEARNING INFORMATION TO USER THROUGH COMMUNICATION TERMINAL - The present invention relates to a method and apparatus for randomly providing learning information to a user through a communication terminal of the user. The present invention has an effect on an improvement of word power of a foreign language or on learning achievement in chemical or scientific formulas for students by providing the learning information through a portable communication terminal held by the user. | 2010-12-23 |
20100323334 | WEB-BASED EMERGENCY RESPONSE EXERCISE MANAGEMENT SYSTEMS AND METHODS THEREOF - According to one embodiment, a method for simulating portions of an emergency response exercise includes generating situational awareness outputs associated with a simulated emergency and sending the situational awareness outputs to a plurality of output devices. Also, the method includes outputting to a user device a plurality of decisions associated with the situational awareness outputs at a decision point, receiving a selection of one of the decisions from the user device, generating new situational awareness outputs based on the selected decision, and repeating the sending, outputting and receiving steps based on the new situational awareness outputs. Other methods, systems, and computer program products are included according to other embodiments of the invention. | 2010-12-23 |
20100323335 | PSYCHOTHERAPEUTIC DEVICE - Disclosed herein is a psychotherapeutic device which induces saccadic eye movement of a user in a certain way, thus increasing the efficacy of psychiatric treatment for the user. The psychotherapeutic device in accordance with the present invention includes a main body including a frame having an opened portion corresponding to a user's eyes, a support means for placing the frame on the user's face, and a front panel connected to a front surface of the frame and providing light spots moved left and right with respect to the user's eyes; and a control box for controlling the operation of the front panel, wherein the main body and the control box are electrically connected to each other by a wire. | 2010-12-23 |
20100323336 | ELECTRONIC SYSTEM FOR ASSISTING THE STUDY AND PRACTICE OF MEDICINE - An electronic system generates and manages multiple knowledge bases of medical students and practitioners. The knowledge bases are organized according to and for the function of specific limited medical problems. Data regarding each problem cross-references both basic sciences and clinical courses. Users are able to create their own knowledge base with the use of teaching data, their own user generated data, and third party user generated data. Data is dynamically updated, and the knowledge bases support the future medical practice of students. | 2010-12-23 |
20100323337 | DENTAL POSITION TRACKING SYSTEM FOR A TOOTHBRUSH - The dental position tracking system includes a toothbrush ( | 2010-12-23 |
20100323338 | APPARATUS FOR DIDACTIC DENTISTRY OPERATIONS - An apparatus for didactic dentistry operations comprising a base structure conformed so as to define a supporting plane raised from the floor, and a dentistry simulation apparatus pivoted to the supporting plane, so as to be able to rotate with respect to the latter between a first operating position, in which the simulation apparatus extends laterally from the bulk of the supporting plane, and a second inactive position in which the simulation apparatus is substantially comprised in the bulk of the supporting plane. The simulation apparatus is pivoted to the supporting plane in correspondence with a median zone of the latter. The supporting plane comprises a housing seating which at least partly accommodates the simulation apparatus in the inactive position thereof. | 2010-12-23 |
20100323339 | Hemodynamic Simulator - The present invention comprises a hemodynamic simulator comprising four manual pumps to simulate the chambers of the heart, at least three valves to simulate valves in the circulatory system, an expandable container to simulate lung venous capacity, an expandable container to simulate arterial distensibility, a series of tubes to simulate peripheral resistance, a pressure gauge to simulate the monitoring of blood pressure; and a reservoir to store fluid to be pumped through the simulator. | 2010-12-23 |
20100323340 | HETERODUPLEX TRACKING ASSAY - A change in viral tropism occurs in many HIV positive individuals over time and may be indicated by a shift in coreceptor use from CCR5 to CXCR4. The shift in coreceptor use to CXCR4 has been shown to correlate with increased disease progression. In patients undergoing HAART, the predominant populations of virus may be shifted back to CCR5-mediated entry soon after the CXCR4-specific strains have emerged. The present invention relates to a diagnostic method to monitor coreceptor use in the treatment and clinical management of human immunodeficiency virus (HIV) infection. The present invention further relates to a diagnostic method applied to HIV-positive individuals undergoing HAART to monitor the suppression of CCR5- or CXCR4-specific strains. The diagnostic methods may be used to assist in selecting antiretroviral therapy and to improve predictions of disease prognosis over time. The methods of the invention include cell-based methods, including cell fusion assays, and molecular-based methods, including heteroduplex tracking assay, to both quantitatively and qualitatively analyze patient-derived HIV for coreceptor usage. | 2010-12-23 |
20100323341 | HETERODUPLEX TRACKING ASSAY - A change in viral tropism occurs in many HIV positive individuals over time and may be indicated by a shift in coreceptor use from CCR5 to CXCR4. The shift in coreceptor use to CXCR4 has been shown to correlate with increased disease progression. In patients undergoing HAART, the predominant populations of virus may be shifted back to CCR5-mediated entry soon after the CXCR4-specific strains have emerged. The present invention relates to a diagnostic method to monitor coreceptor use in the treatment and clinical management of human immunodeficiency virus (HIV) infection. The present invention further relates to a diagnostic method applied to HIV-positive individuals undergoing HAART to monitor the suppression of CCR5- or CXCR4-specific strains. The diagnostic methods may be used to assist in selecting antiretroviral therapy and to improve predictions of disease prognosis over time. The methods of the invention include cell-based methods, including cell fusion assays, and molecular-based methods, including heteroduplex tracking assay, to both quantitatively and qualitatively analyze patient-derived HIV for coreceptor usage. | 2010-12-23 |
20100323342 | MICRO-DEVICE AND METHOD FOR SELECTIVE AND NON-INVASIVE SEPARATION AND EXTRACTION OF PARTICLES IN POLYDISPERSED SUSPENSIONS, MANUFACTURING PROCESS AND APPLICATIONS THEREOF - The present invention relates to a micro-device for selective and non-invasive separation of particles in polydispersed suspensions through the strategic use of ultrasounds, laminar flow and standing wave effects in a channel produced in a chip by means of microtechnology. Said device is a resonant multi-layer system with a modified lambda quarter-type treatment channel, which enables the particles to be channeled and separated in a flow inside the substrate channel without touching the walls of the device, in order to avoid problems of adherence. Said micro-device can be used in the field of biomedicine and/or biotechnology for the separation and concentration of cells, preferably human cells, applicable to research and medical processes for diagnosis and treatment. | 2010-12-23 |
20100323343 | METHODS AND COMPOSITIONS FOR ANALYTE DETECTION - The present invention is directed to methods and apparatus for detection of one or more analytes. Analytes include agents or components of infectious agents such as pathogenic virus, as well as enzymes, proteins and biomarkers. | 2010-12-23 |
20100323344 | Detection of hepatitis C virus RNA - The methods and compositions of this invention provide a means for determining the presence of Hepatitis C virus (HCV) in a sample from an individual. This is accomplished by hybridization to tissue samples using a cRNA probe that is specific for HCV. These means allow superior detection of HCV infection by virtue of the RNA riboprobe. | 2010-12-23 |
20100323345 | METHODS AND COMPOSITIONS FOR IDENTIFYING CELLS BY COMBINATORIAL FLUORESCENCE IMAGING - A method of identifying the classification of cells in situ involves labeling the cells with a set of nucleic acid probes and performing combinational fluorescence microscopic imaging. The set of probes contains groups of probes that bind to a taxon-specific or function-specific nucleotide sequence. Each probe of a group of probes is labeled with a distinct fluorescent label, and each group corresponds to a unique combination of labels, which can be detected across the image and serves to identify cells according to a unique taxonomic or functional classification. The combinational labeling and spectral imaging approach expands the number of different classifications that can be identified simultaneously in a single image of a collection of cells. The methods and probe sets of the invention can be used to rapidly identify microbes, study their ecological relationships, screen for novel antibiotics, and identify pathogens. | 2010-12-23 |
20100323346 | Method of Examining Inflammatory Disease and Method of Screening Remedy for Inflammatory Disease - A single nucleotide polymorphism occurring on a leptin receptor gene is analyzed and an inflammatory disease is examined on the basis of the analytical data. Further, a substance capable of changing the interaction between the leptin receptor and galectin-2 is selected to thereby screen a remedy for an inflammatory disease. | 2010-12-23 |
20100323347 | Method for Evaluating or Selecting Agent for Preventing or Curing Photodamage of Skin - A method for evaluating or selecting a substance capable of preventing or curing photodamage of skin is provided. Provided is a method for evaluating or selecting an agent for preventing or curing photodamage of skin, the method including: (A) contacting cells that are capable of expressing TIMP-1 gene or TIMP-1 protein, with a test substance; (B) measuring the expression level of the TIMP-1 gene or the TIMP-1 protein in the cells; (C) comparing the expression level obtained in (B), with the expression level of TIMP-1 gene or TIMP-1 protein in a control group in which the cells capable of expressing TIMP-1 gene or TIMP-1 protein have not been contacted with the test substance; and (D) evaluating or selecting the test substance which increases the expression level of TIMP-1 gene or TIMP-1 protein, as an agent for preventing or curing photodamage of skin, based on the results of (C). | 2010-12-23 |
20100323348 | Methods and Compositions for Using Error-Detecting and/or Error-Correcting Barcodes in Nucleic Acid Amplification Process - The present invention provides methods and compositions for detecting and correcting errors in nucleic acid amplification processes, and methods for using the same. In particular, barcode amplification errors are detected and corrected such that integrity in sample assignment is maintained. The methods are compatible with high throughput sequencing techniques as some of the barcodes are based upon Hamming codes, thereby allowing self-correction for single bit errors. Some methods and compositions of the invention allow characterization (e.g., sequencing) of a plurality of nucleic acid samples simultaneously within a single sequencing reaction. | 2010-12-23 |
20100323349 | Identification of the Gene and Mutation Responsible for Progressive Rod-Cone Degeneration in Dog and a Method for Testing Same - Tools and methods are provided for determining whether or not a dog is genetically normal, is a carrier of, or is affected with or predisposed to progressive rod-cone degeneration. The method is based on the detection of a transversion from G to A at position corresponding to nucleotide position 1298 of SEQ ID NO: 1. | 2010-12-23 |
20100323350 | Methods And Devices For Sequencing Nucleic Acids In Smaller Batches - The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. A plurality of smaller flow cells is employed, each with a relatively small area to be imaged, in order to provide greater flexibility and efficiency. | 2010-12-23 |
20100323351 | TUMOR SUPPRESSOR GENE, P47ING3 - The invention provides isolated nucleic acid and amino acid sequences of novel human tumor suppressors, antibodies to such tumor suppressors, methods of detecting such nucleic acids and proteins, methods of screening for modulators of tumor suppressors, and methods of diagnosing and treating tumors with such nucleic acids and proteins. | 2010-12-23 |
20100323352 | Marker for Prenatal Diagnosis and Monitoring - The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status. | 2010-12-23 |
20100323353 | MARKER ASSISTED DIRECTED EVOLUTION - The present invention is directed at a novel method to enhance the genetic improvement of industrial microorganisms. More specifically, the present invention is directed at molecular methods for the identification of genetic variants that contribute to the genetic improvement of the microorganisms. The methods of the present invention comprise novel approaches for identifying genetic markers that linked to said genetic variants, and for using said genetic markers to select improved industrial microorganisms. In one of the embodiments, the genetic markers linked to said genetic variants are identified in microbial populations that are subjected to directed evolution. In another embodiment the genetic markers linked to said genetic variants are identified in microbial sub populations that have been prescreened for improved characteristics. The primary benefits of the use of the methods of the present invention include the speeding up of the directed evolution process for the genetic improvement of industrial microorganisms and the enhancement of the improvement itself. Indeed the improved industrial microorganisms obtained with the methods of the present invention are superior over those obtained by conventional methods because the methods allow more beneficial genetic variants to be combined together in a single genetic improvement step. Finally, it is anticipated that the methods of the present invention can be utilized on any industrial microorganism for which natural genetic diversity is available, including bacteria, yeasts, fungi and algae. | 2010-12-23 |
20100323354 | MEANS AND METHODS FOR THE DETECTION AND ISOLATION OF FETAL AND EMBRYONIC CELLS AND NUCLEIC ACID FROM MATERNAL BODY FLUID - The present invention is related to the use of an interaction partner of a high mobility group protein of the HMGA family for the detection of fetal and embryonic cells in a maternal body fluid. | 2010-12-23 |
20100323355 | MEANS AND METHODS FOR DETECTION OF NUCLEIC ACIDS - The present invention related to methods and tools for nuclease-dependent detection of nucleic acid hybridization. In these methods magnetic or magnetizable particles are used to discriminate between hybridized and non-hybridized DNA. | 2010-12-23 |
20100323356 | SMALL RNA-DEPENDENT TRANSLATIONAL REGULATORY SYSTEM IN CELL OR ARTIFICIAL CELL MODEL - An object of the present invention is to construct an mRNA which specifically responds to a short RNA sequence and can activate, repress, and regulate the translation of the desired gene, and to construct an artificial cell model system using a liposome comprising the mRNA and a cell-free translational system encapsulated therein. The present invention provides: an mRNA comprising a target RNA-binding site located immediately 5′ to the ribosome-binding site, and a nucleotide sequence located 5′ to the target RNA-binding site, the nucleotide sequence being complementary to the ribosome-binding site; an mRNA comprising a small RNA-binding site located 3′ to the start codon, and a nucleotide sequence located 3′ to the small RNA-binding site, the nucleotide sequence encoding a protein; and a liposome comprising any of these mRNAs encapsulated therein. | 2010-12-23 |
20100323357 | MicroRNA Expression Profiling and Targeting in Peripheral Blood in Lung Cancer - A method for the diagnosis, prognosis and treatment of lung cancer by detecting at least one microRNA in peripheral blood is disclosed. | 2010-12-23 |
20100323358 | Use of KIR genes for predicting response to therapy - The present invention relates to the use of at least one Killer cell immunoglobulin-like receptor gene for the identification of subjects likely to respond to tumour necrosis factor-based therapy. The invention also provides methods of identifying subjects likely to respond to tumour necrosis factor-based therapy, and finds utility in assisting with prospectively predicting the likely clinical response of patients to therapeutic agents used in TNF therapy, based on the genotype of the patient, in particular, by evaluating the status of at least one KIR gene. This predictive tool finds wide clinical utility in the management of autoimmune diseases, such as rheumatoid arthritis, and greatly assists clinicians in the prioritisation of patients for tumour necrosis factor-based therapy, possibly reducing the cost of treatment in terms of adverse side effects and health budgets. | 2010-12-23 |
20100323359 | Methods for identifying analgesic agents - The present invention relates to the discovery that mutations in SCN9A are causative of Congenital Indifference to Pain (CIP) in humans. The invention also relates to methods of utilizing the SCN9A gene and expression products thereof for the screening and identification of therapeutic agents, including small organic compounds, which are selective for SCN9A, and are useful in the treatment of pain and other disorders. The invention also relates to methods of using these compounds to treat or otherwise ameliorate such disorders. | 2010-12-23 |
20100323360 | Oligonucleotide arrangements, processes for their employment and their use - Oligonucleotide arrangements are disclosed which, in each case, have at least two oligonucleotide sequences linked via at least one spacer. A process is disclosed using the oligonucleotide arrangements for the amplification and/or detection of nucleic acid sequences with formation of crosslinked conglomerates. The process can be used, for example, for the sensitive, simple and inexpensive detection of nucleic acid sequences. | 2010-12-23 |
20100323361 | METHODS, SYSTEMS AND KITS FOR DETECTING PROTEIN-NUCLEIC ACID INTERACTIONS - Methods, systems and kits for detecting protein-nucleic acid interactions, in particular, detecting the genomic location to near-base pair resolution at which a particular protein (e.g., transcription factor) binds includes combining steps of a convention chromatin immunoprecipitation (ChIP) assay with use of an exonuclease that digests DNA strands in the 5′-3′ or 3′-5′ direction until it reaches a bound protein including a protein crosslinked to DNA. A significant improvement of the resolution and dynamic range of the ChIP assay will increase one's ability to determine with confidence where a particular protein is binding in the genome. Importantly, proteins that inefficiently crosslink to DNA (either intrinsically or due to indirect crosslinking via another protein) and thus are very difficult to detect, are expected to be significantly detected by the kits and methods described herein. Inasmuch as most aspects of infectious diseases, inborn diseases, and cancers are rooted in the mis-expression of genes, having a better measure of the binding of proteins to genes or promoter regions will greatly enhance the ability of investigators to understand the driving molecular mechanisms behind these human maladies. | 2010-12-23 |
20100323362 | COMPOSITIONS AND METHODS FOR DETECTING NUCLEIC ACID FROM MOLLICUTES - Compositions, reaction mixtures, kits and methods used in amplifying and detecting nucleic acids from various species of the class Mollicutes. Particular regions of the 23S rRNA or its gene have been identified as preferred targets for nucleic acid amplification reactions of a sample suspected containing at least one species of Mollicutes. Some oligomers comprise tag regions, target closing regions, promoter sequences, and/or binding moieties. Samples can be from any source suspected of containing a species of the class Mollicutes. Preferred sample sources include bioreactors, cell lines, cell culture wares and pharmaceutical manufacturing wares. | 2010-12-23 |
20100323363 | METHOD FOR THE TREATMENT OF A SAMPLE CONTAINING BIOMOLECULES - The invention generally provides a method for the sample preparation for a subsequent preparation, processing or analysis method of a sample containing an at least one species of nucleic acid and/or one species of protein, whereby the method comprises the following steps: A) providing a sample which contains at least one species of a nucleic acid and/or of a protein, B) contacting the sample with a fluid or solid composition to produce a fluid sample preparation, whereby the composition contains at least a nitrogenous compound, which is selected from the group consisting of a) polyamines, b) amino acids, and oligo- and polypeptides, c) nitrogenous heterocyclic compounds, including homo- oder heteropolymeres, which comprise these nitrogenous compounds, d) amines of the type R | 2010-12-23 |
20100323364 | MODIFIED tRNA CONTAINING UNNATURAL BASE AND USE THEREOF - In the method for introducing a noncanonical amino acid residue into a desired position in a protein, the structure of tRNA is so modified as to have improved affinity for aminoacyl-tRNA synthetase or improved specificity to aminoacyl-tRNA synthetase. An unnatural base is contained at any position in tRNA, whereby the efficiency of aminoacylation of the tRNA with a noncanonical amino acid can be improved. | 2010-12-23 |
20100323365 | PRIMER AND PROBE FOR DETECTING CHLAMYDOPHILA CAVIAE, AS WELL AS A CHLAMYDOPHILA CAVIAE DETECTION METHOD USING THE SAME - Provided are a novel primer and a probe for the detection of | 2010-12-23 |
20100323366 | Methods of Selecting a Dopaminergic Neuron Proliferative Progenitor Cells Using LRP4/CORIN Markers - In neuron transplantation therapy, in terms of safety, it is preferable to use a cell population consisting only of a desired type of cells, and to use postmitotic neurons in consideration to avoid the risk of tumorigenesis. Moreover, greater therapeutic effects would be expected through the use of earlier progenitor cells in consideration of post-transplantation viability, proper network formation ability, and such. | 2010-12-23 |
20100323367 | METHOD OF DETECTING COLON CANCER MARKER - It is intended to provide a non-invasive and convenient method of detecting a tumor marker for diagnosing colon cancer which is superior in sensitivity and specificity to the existing fecal occult blood test. More specifically speaking, a method of detecting a tumor marker for diagnosing colon cancer which comprises collecting biological sample which is immediately frozen using liquid nitrogen in some cases, homogenizing the sample in the presence of an inhibitor of an RNA digesting enzyme to give a suspension, extracting RNA from the obtained suspension, subjecting the extracted RNA to reverse transcription to give cDNA. amplifying the obtained cDNA and then detecting the thus amplified cDNA. This method is characterized by involving no procedure of separating cell components from the biological sample. | 2010-12-23 |
20100323368 | Cytokine production-inducing antibody - The invention relates to a method of measuring the activation of an effector cell belonging to the immune system, which may or may not be transformed, using a monoclonal (AcMo) or polyclonal antibody. The invention is characterised in that it consists in: bringing into contact (i) CD16 receptor-expressing cells in a reaction medium in the presence of the antibody and (ii) the antigen of said antibody, and measuring the quantity of at least one cytokine produced by the CD16 receptor-expressing cell. The invention also relates to the selection of an antibody capable of inducing the expression of cytokines and interleukins, such as IFN? or IL2 which are intended for the treatment of autoimmune and inflammatory diseases, cancers and infections by pathogens. | 2010-12-23 |
20100323369 | Diagnostic Testing Process - A method and apparatus for use in a flow through assay process is disclosed. The method is characterised by a “pre-incubation step” in which the sample which is to be analysed (typically for the presence of a particular protein), and a detection analyte (typically one or more antibodies bound to colloidal gold or a fluorescent tag) which is known to bind to the particular protein may bind together for a desired period of time. This pre-incubation step occurs before the mixture of sample and detection analyte come into contact with a capture analyte bound to a membrane. The provision of the pre-incubation step has the effect of both improving the sensitivity of the assay and reducing the volume of sample required for an assay. An apparatus for carrying out the method is disclosed defining a pre-incubation chamber for receiving the sample and detection analyte having a base defined by a membrane and a second membrane to which a capture analyte is bound. In one version the pre-incubation chamber is supported above the second membrane in one position but can be pushed into contact with the membrane carrying the capture analyte thus o permitting fluid transfer from the incubation chamber through the capture membrane. In another version the membrane at the base of the incubation chamber is hydrophobic and its underside contacts the capture membrane and when a wetting agent is applied to the contents of the pre-incubation chamber fluid transfer occurs. | 2010-12-23 |
20100323370 | METHOD FOR DETERMINING IMMUNE SYSTEM AFFECTING COMPOUNDS - The present invention relates to a method for increasing efficacy and/or possibility of therapeutic treatment of cancer, wherein any dys-regulatory mechanism, including inducing factor/s, of the production of immunoregulatory substances, including one or more cytokines, including IL-1β, IL-1Ra, IL-6, IL-10, IL-17, TNF-α, and others, is therapeutically controlled to minimise pathological production of such immunoregulatory substances, to enhance the therapeutic control of a malignant tumour in a subject suffering from a cancer, a method for analysing dys-regulatory mechanism controlling substances, kit for such analysis, use of certain compounds for preparing pharmaceutical preparations, and pharmaceutical preparations. | 2010-12-23 |
20100323371 | STROMAL INTERACTING MOLECULE KNOCKOUT MOUSE AND USES THEREOF - This invention relates to knockout mice for the Ca | 2010-12-23 |
20100323372 | IMMUNOASSAY ASSEMBLY AND METHODS OF USE - The present invention relates to an improved system for efficiently and accurately performing immunoassays, such as ELISAs. The invention provides an immunoassay assembly which includes a flow-through unit and an aspiration pump. The immunoassay flow-through unit includes an outer seal; at least one bed support; an inner seal; and a packed non-porous bed. The unit is releasably attached to an aspiration pump which enables the controlled flow rate of liquid passing through the packed bed of the flow-through unit. The invention also provides a method of using the immunoassay assembly to identify analytical targets of interest. | 2010-12-23 |
20100323373 | METHOD FOR THE ASSESSMENT OF THE INHIBITORY ACTIVITY OF ANTIBODIES AGAINST INSULIN-LIKE GROWTH FACTOR I RECEPTOR - A method for the assessment of the inhibitory activity of an antibody for inhibiting the binding of IGF-1 and/or IGF-2 to IGF-1R in a lysed PBL sample of a mammal which has been treated with said antibody, characterized in that the IGF-1R protein level of said PBLs is measured as a measure for the inhibitory activity of said antibody. | 2010-12-23 |
20100323374 | Serum Biomarkers for Diagnosing Liver Fibrosis and Method for Measuring the Same - Disclosed are serum biomarkers for diagnosing liver fibrosis and methods for measuring the same. The serum biomarkers obtained from human serum include alpha2-macroglobulin (“A2M”), vitamin D binding protein (“VDBP”), apolipoprotein AI (“ApoAI”). The methods involve with immunoassay using specific antibodies to detect the biomarkers, including enzyme-linked immunosorbent assay (“ELISA”), radio immune assay (“RIA”) and flexible multi-analyte profiling (“xMAP”). ELISA, RIA or xMAP is used to measure changes of protein concentration for the specific protein biomarkers in serum for diagnosing liver fibrosis with suffering hepatitis B or C or other liver diseases. The measurement is safe and accurate. The method can be used before and after treatment of liver fibrosis. Thus, it is possible to achieve early diagnosis and treatment advocated in the preventive medicine. | 2010-12-23 |
20100323375 | AGENT AND METHOD FOR DIAGNOSIS ON THE OCCURRENCE OF ALZHEIMER'S DISEASE OR THE TENDENCY TO DEVELOP ALZHEIMER'S DISEASE - Disclosed are: an agent, an apparatus and a method for the diagnosis of a disease associated with the abnormality in γ-secretase; a method for providing information for the diagnosis of a disease associated with the abnormality in γ-secretase; a method for monitoring the condition or the degree of progression of a disease associated with the abnormality in γ-secretase; and a method for determining the therapeutic effect of a therapeutic agent on a disease associated with the abnormality in γ-secretase. More specifically disclosed are: a diagnostic agent for a disease associated with the abnormality in γ-secretase, which comprises an antibody capable of recognizing a digestion product of an alcadein with α-secretase or γ-secretase or a fragment of the antibody; and others. | 2010-12-23 |
20100323376 | Method for Measuring Lipoprotein-Specific Apolipoproteins - The present invention is directed to methods of measuring the concentration of lipoprotein particles and/or lipoprotein-specific apolipoproteins in a biological fluid using an immunoassay, without the need of preliminary physical separation of the various types of lipoprotein particles present in the biological fluid. | 2010-12-23 |
20100323377 | BIOCHEMICAL MARKERS FOR CVD RISK ASSESSMENT - A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a protein of an atherosclerotic plaque such as lumican, versican, perlecan, decorin, biglycan, collagen type III, CRP, ApoE, or elastin, by a proteinase, said comprises contacting a sample such as urine or serum with an antibody reactive with the neo-epitope and determining the level of binding of said immunological binding partner to peptide fragments in said sample. The assay is predictive of risk of cardiovascular disease events. | 2010-12-23 |
20100323378 | MODIFIED GLUCOSE DEHYDROGENASE GENE - [Object] To provide an FAD-conjugated glucose dehydrogenase having a higher specificity for glucose. | 2010-12-23 |
20100323379 | SLEEP APNEA - This document relates to methods and materials involved in diagnosing sleep apnea and assessing the effectiveness of a treatment for sleep apnea. For example, methods and materials for using markers to determine whether or not a mammal (e.g., a human) has sleep apnea are provided. In addition, methods and materials that can be used to determine whether or not a mammal (e.g., a human) responds to a sleep apnea treatment are provided. | 2010-12-23 |
20100323380 | METHODS FOR DIAGNOSING BLOOD VESSEL REOCCLUSION - The present invention features a method of diagnosing blood vessel reocclusion in a subject by detecting increased levels of sFLT-1 in a biological sample from the subject. | 2010-12-23 |
20100323381 | CLASSIFYING AMYLOIDOSIS - This document provides methods and materials related to determining the identity of amyloid polypeptides in biological samples. For examples, methods and materials for identifying an amyloid polypeptide present in a fat aspirate are provided herein. | 2010-12-23 |
20100323382 | METHOD FOR ASSAYING BILIRUBIN AND ASSAY INSTRUMENT USED IN BILIRUBIN ASSAY - A method for assaying bilirubin in which a dry reagent is used, which is capable of accelerating the reaction of bilirubin oxidase, and an assay instrument to be used in the method for assaying bilirubin, are provided. The method for assaying bilirubin is characterized in that a biological sample and a bilirubin oxidase-containing dry reagent are mixed first, and then the mixture obtained and a surfactant-containing dry reagent are mixed. An assay instrument ( | 2010-12-23 |
20100323383 | Methods for in vitro differentiation of Th-17+cells - The present invention is directed to an in vitro method for promoting differentiation and proliferation of human T helper lymphocytes that express IL17 (Th-IL17+ cells). | 2010-12-23 |
20100323384 | LABELING OF HUMAN EPIDERMAL STEM CELLS - The present invention provides skin equivalents comprising human epidermal stem cells which are specifically labeled. The labeling is carried out with a marker capable of labeling slowly proliferating cells, e.g. iododeoxyuridine or PKH26. Particularly, the invention provides skin equivalents comprising labeled epidermal stem cells. The invention also provides corresponding uses and methods of using such cultures, e.g. in the fields of research and medical treatment of skin diseases. | 2010-12-23 |
20100323385 | NITROGEN INDEPENDENCE IDENTIFIES A HIGHLY MALIGNANT POPULATION OF TUMOR STEM CELLS - The present invention is directed to a method for isolating and establishing Growth Factor-Independent (GF-I) Tumor Stem Cells (TSCs) from tumor biopsies or tumor cell lines consisting in culturing cells in serum-free mitogen-free culture medium. The method discloses cell growth in a culture medium, which does neither comprise serum, nor EGF (Epidermal Growth factor) and FGF-2 (Fibroblast Growth Factor), nor both, nor EGF or FGF-2 derivatives with the same mitogenic characteristics of the parent molecules. According to a preferred embodiment, the method is directed to the isolation of Tumor stem cells (TSCs) from glioblastoma multiforme (GBM) or from other brain tumors or brain tumor cell lines. GF-Independent TSCs can be identified and expanded in vitro providing a homogeneous population of multipotent, self-renewing and highly tumorigenic Growth Factor-Independent TSCs, distinguishable from tumor stem cells derived with other methods, grown in parallel, for the above characteristics. The invention also encompasses therapeutic methods based on Tumor Stem Cells isolated as described. | 2010-12-23 |
20100323386 | Method and apparatus to indicate combustor performance for processing chemical/biological contaminated waste - Methods and apparatus are used for monitoring the effectiveness of a heat treatment to inactivate a contaminant in or on common building materials. The temperature is monitored or evaluated by using an internal control having a biological, chemical or electronic sensor. The sensor is bundled in common building materials to provide insulating properties so as to mimic bundles of contaminated building materials being bundled for incineration. | 2010-12-23 |
20100323387 | Optimization of Response to Light - Various aspects provide for exposing a substance to light. Certain aspects include exposing a suspension of photosynthetic organisms to sunlight, and may include optimizing exposure to improve photosynthesis conditions. Certain embodiments include controlling an opacity or opacity profile of a suspension of algae and/or diatoms. Optimizing exposure may include maximizing growth rate, maximizing photosynthesis efficiency, maximizing lipid production, minimizing damage, minimizing predator growth, maximizing a capacity to grow in suboptimal media (e.g., polluted water, brackish water, or water having a pH outside of a preferable range), minimizing requirements for nutrients, and other features. | 2010-12-23 |
20100323388 | BIOCHIP FOR HIGH-THROUGHPUT SCREENING OF CIRCULATING TUMOR CELLS - Embodiments in accordance with the present invention relate to the use of effusive filtration to segregate tumor cells from a sample of bodily fluid. In one embodiment, fluid containing a cell is flowed down a channel having a filtration medium present along at least one side wall. The tumor cell is captured when the fluid passes through the filtration medium. Accumulated pressure on the captured tumor cell is reduced by allowing the fluid that has passed through the filtration medium to re-enter the channel. In a particular embodiment, the filtration medium may comprise side wall apertures having a width smaller than that of the cell, with downstream apertures allowing re-entry of the fluid into the channel. | 2010-12-23 |
20100323389 | FLUORESCENT IMAGING WITH SUBSTITUTED CYANINE DYES - Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: | 2010-12-23 |
20100323390 | Method for the Identification of a Metabolic Pathway Family by Means of Positive Selection - The invention relates to the direct selection of metabolic pathways having a determined function in the transformation of a substrate {Ai} into a target product {B}, which is of interest in the industrial, pharmaceutical or agri-food sectors. More specifically, the invention relates to the detection, within metagenomic libraries, of novel biosynthesis pathways involved in a biochemical reaction having a known product {B}. The selection and characterisation of said novel metabolic pathways enables {B} to be produced enzymatically. The invention provides an alternative to the chemical synthesis of the molecule in question {B}. Moreover, and above all, the invention can be used specifically to target and exploit the only metabolic pathways enabling the transformation of {Ai} into {B}, while eliminating the associated metabolic pathways that can catabolise the target product {B}. | 2010-12-23 |
20100323391 | Method of Detecting Microorganisms with a Specimen - This invention concerns a process for preparing reagents intended for a microorganism detection test and notably an infection in humans or animals, wherein the following steps are included:
| 2010-12-23 |
20100323392 | Metering Technique for Lateral Flow Assay Devices - A diagnostic test kit for detecting an analyte residing in a test sample is provided. The kit employs a lateral flow device that contains a membrane. A metering channel is formed in the membrane that is capable of delivering a controlled volume of the test sample to a detection zone upon initiation of the assay. Such a metering channel is particularly effective for embodiments in which the test sample has a relatively low volume, such as less than about 100 microliters, in some embodiments from about 0.5 to about 25 microliters, and in some embodiments, from about 1 to about 10 microliters. For example, whole blood drops obtained from patients with a lancet typically have a volume of less than about 3 microliters. Despite their low volume, the present inventors have discovered that the blood drops may still be accurately analyzed for the presence of an analyte using lateral flow detection techniques. | 2010-12-23 |
20100323393 | Ordered Assembly of Membrane Proteins During Differentiation of Erythroblasts - Disclosed herein are methods for the isolation, identification, and quantification of red blood cells and red blood cell precursors at different developmental stages. Also disclosed are methods for monitoring ex vivo proliferation and differentiation of red blood cells and red blood cell progenitors. | 2010-12-23 |
20100323394 | INTEGRATED FILTRATION AND DETECTION DEVICE - An integrated filtration and detection device for collecting and detecting the growth of microorganisms in a specimen includes a container defining a chamber therein. The container has an inlet and an outlet in fluid communication with the chamber. A filter is mounted in the chamber between the inlet and the outlet. A sensor is mounted in the chamber. The sensor is operative to exhibit a change in a measurable property thereof upon exposure to changes in the chamber due to microbial growth. | 2010-12-23 |
20100323395 | Method For Automatically Processing Tissue Samples In A Tissue Processor - In the automatic processing of tissue samples in a tissue processor, the tissue samples are placed in a retort of the tissue processor. The tissue samples are exposed to a fixation reagent (FIX) in the retort. Afterwards, the tissue samples are exposed to a dehydrating reagent (ALK). Thereafter, the retort is cleared with an intermedium (INT) for removing the dehydrating reagent (ALK). Finally, the tissue samples are treated with a carrier material (CAR). Between the clearing of the retort with the intermedium (INT) and the treatment of the tissue samples with the carrier material (CAR), the retort is cleared with a carrier material protecting reagent (CARPRO) in which the intermedium (INT) and the carrier material (CAR) can be mixed. | 2010-12-23 |
20100323396 | PLATELET MEASUREMENT REAGENT, PLATELET MEASUREMENT REAGENT KIT, AND PLATELET MEASUREMENT METHOD - A reagent for measuring platelets comprising Nile Blue hydrogensulfate, or Nile Blue and an acid, a reagent kit for measuring platelets comprising the reagent for measuring platelets, and a method for measuring platelets using the reagent or reagent kit. | 2010-12-23 |
20100323397 | MODIFIED VIRD2 PROTEIN AND ITS USE IN IMPROVED GENE TRANSFER - There is provided a method for | 2010-12-23 |
20100323398 | Baculoviruses With Enhanced Virion Production and a Method for the Production of Baculoviruses - The present invention provides a method for restoring budding capability to GP64null baculoviruses including gp64null AcMNPV by expressing therein a portion of the VSV G protein gene or a truncated “stem” portion of the GP64 gene. Other embodiments provide methods to use portions of the G-stem or GP64 protein to target foreign proteins for display on virions. | 2010-12-23 |