51st week of 2011 patent applcation highlights part 47 |
Patent application number | Title | Published |
20110312600 | GENETIC ANALYSIS LOC WITH THERMAL BEND ACTUATED PRESSURE PULSE VALVE - A lab-on-a-chip device (LOC) for genetic analysis having a supporting substrate, an array of probes for hybridization with target nucleic acid sequences to form probe-target hybrids, a channel for directing a flow of liquid containing the target nucleic acid sequences, the channel having an inlet, an outlet and a meniscus anchor between the inlet and the outlet such that the flow from the inlet towards the outlet stops at the meniscus anchor where the liquid forms a meniscus, and, an actuator valve with a movable member for contacting the liquid, and a thermal expansion actuator for displacing the movable member to generate a pulse in the liquid to dislodge the meniscus such that the liquid flow towards the outlet resumes. | 2011-12-22 |
20110312601 | LOC DEVICE WITH DIGITAL MEMORY FOR SECURE STORAGE OF DATA - A lab-on-a-chip (LOC) device for analyzing a sample fluid, the LOC device having a sample inlet for receiving the sample, a microsystems technology (MST) layer with functional sections for processing and analyzing the sample, and, CMOS circuitry with digital memory for storing data and operational information to operatively control the functional sections during processing and analysis of the sample, wherein, the data is encrypted for secure communication with an external device. | 2011-12-22 |
20110312602 | GENETIC ANALYSIS LOC WITH THERMAL BEND ACTUATED SURFACE TENSION VALVE - A lab-on-a-chip (LOC) device for genetic analysis having a supporting substrate, an array of probes for hybridization with target nucleic acid sequences to form probe-target hybrids, a channel for directing a flow of liquid containing the target nucleic acid sequences, the channel having an inlet, an outlet and a meniscus anchor between the inlet and the outlet such that the flow from the inlet towards the outlet stops at the meniscus anchor where the liquid forms a meniscus, and, an actuator valve with a movable member for contacting the liquid, and an actuator for displacing the movable member from a quiescent position to an actuated position where the meniscus is extended into contact with a surface downstream of the meniscus anchor such that the liquid flow towards the outlet resumes. | 2011-12-22 |
20110312603 | TEST MODULE WITH LOC HAVING ON-CHIP ELECTRONICS FOR MODULE CONTROL - A test module for analyzing a sample fluid, the test module having a receptacle for receiving the sample, functional sections for processing and analyzing the sample, a supporting substrate, and, CMOS circuitry on the supporting substrate for operative control of the functional sections during processing and analysis of the sample. | 2011-12-22 |
20110312604 | LOC HAVING ON-CHIP ELECTRONICS FOR USE IN A TEST MODULE TO CONTROL MODULE COMMUNICATIONS - A lab-on-a-chip (LOC) device for installation in a test module for analyzing a sample fluid and communicating test results to an external device, the LOC device having a supporting substrate, a sample inlet for receiving the sample, a microsystems technology (MST) layer with functional sections for processing and analyzing the sample, and, CMOS circuitry on the supporting substrate for operative control of a communication interface in the test module for communication with the external device. | 2011-12-22 |
20110312605 | LOC DEVICE WITH INTEGRAL CONTROLLER - A lab-on-a-chip (LOC) device for analyzing a sample fluid, the LOC device having a supporting substrate, a sample inlet for receiving the sample, a microsystems technology (MST) layer with functional sections for processing and analyzing the sample, and, CMOS circuitry between the supporting substrate and the MST layer, the CMOS circuitry having a controller to control operations performed by the functional sections during processing and analysis of the sample. | 2011-12-22 |
20110312606 | LOC DEVICE WITH DIGITAL MEMORY - A lab-on-a-chip (LOC) device for analyzing a sample fluid, the LOC device having a supporting substrate, a sample inlet for receiving the sample, a microsystems technology (MST) layer with functional sections for processing and analyzing the sample, and, CMOS circuitry between the supporting substrate and the MST layer, the CMOS circuitry having digital memory for storing data and operational information to operatively control the functional sections during processing and analysis of the sample. | 2011-12-22 |
20110312607 | GENETIC ANALYSIS LOC WITH HYBRIDIZATION ARRAY WITH CALIBRATION PHOTOSENSOR OUTPUT SUBTRACTED IN A DIFFERENTIAL CIRCUIT FROM THE OUTPUT OF HYBRIDIZATION PHOTOSENSORS - A microfluidic device having a supporting substrate, an inlet for receiving a biological sample containing target nucleic acid sequences, probes that each have a nucleic acid sequence for hybridization with a respective one of the target nucleic acid sequences to form a probe-target hybrid and emit a fluorescence signal in response to an excitation light, and, photosensors corresponding to each of the probes respectively, and, a calibration photosensor not corresponding to any of the probes such that output from the calibration photosensor is subtracted in a differential circuit from each output from the photosensors. | 2011-12-22 |
20110312608 | TEST MODULE WITH LOW-VOLUME HYBRIDIZATION CHAMBER AND LOW-VOLUME REAGENT RESERVOIR - A test module having an outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, a reagent reservoir containing a reagent for addition to the biological sample, and, a hybridization chamber containing probes having a nucleic acid sequence for hybridization with the target nucleic acid sequence to form probe-target hybrids, wherein, the reagent reservoir has a volume less than 20,000,000 cubic microns and the hybridization chamber has a volume less than 9,000 cubic microns. | 2011-12-22 |
20110312609 | TEST MODULE FOR ORIENTATION-INDEPENDENT OPERATION - A test module for analyzing genetic material in a biological sample, the test module having an outer casing with a receptacle for receiving the biological sample, functional sections for processing and analyzing the biological sample, a controller for operating the functional sections, and, a flow-path from the receptacle to the functional sections, wherein, the flow-path is configured to draw the sample to be analyzed from the receptacle to the functional sections by capillary action regardless of module orientation. | 2011-12-22 |
20110312610 | TEST MODULE WITH LONG FLUORESCENCE LIFETIME PROBES - A test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, and, probes in the outer casing for hybridization with the target nucleic acid sequence to form probe-target hybrids, the probes each having a fluorophore such that the probe-target hybrids emit a fluorescence signal in response to exposure to an excitation light, wherein, the fluorophore has a fluorescence lifetime greater than 100 nanoseconds. | 2011-12-22 |
20110312611 | TEST MODULE WITH TRANSITION METAL-LIGAND COMPLEX FLUOROPHORE - A test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, and, probes in the outer casing for hybridization with the target nucleic acid sequence to form probe-target hybrids, the probes each having a fluorophore such that the probe-target hybrids emit a fluorescence signal in response to exposure to an excitation light, wherein, the fluorophore is a transition metal-ligand complex. | 2011-12-22 |
20110312612 | LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET SEQUENCES WITH PROBES BETWEEN A WORKING ELECTRODE AND A PHOTOSENSOR - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, and, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, wherein, the electrodes are arranged in pairs, one of the electrodes in each electrode pair being a working electrode which causes oxidation or reduction of the luminophore to generate an excited species that emits a photon, the working electrode being positioned such that the probes are between the photosensor and the working electrode. | 2011-12-22 |
20110312613 | CARRIERS FOR COMBINATORIAL COMPOUND LIBRARIES - A carrier pre-encoded with information sufficient to distinguish it from a heterogeneous population of carriers is disclosed on which a compound can be synthesised. The carrier has two attributes integrally associated therewith, which attributes are detectable and/or quantifiable during synthesis of the compound and which define a code identifying the carrier before, during and after said synthesis, with the proviso that one of said attributes is other than shape, or surface deformation(s) of the carrier. The invention also encompasses a plurality of carriers that are pre-encoded as above and a method of synthesising and deconvoluting a combinatorial library using such carriers. | 2011-12-22 |
20110312614 | METHODS FOR RAPID MULTIPLEXED AMPLIFICATION OF TARGET NUCLEIC ACIDS - A fast, multiplexed PCR system is described that can rapidly generate amplified nucleic acid products, for example, a full STR profile, from a target nucleic acid. Such systems include, for example, microfluidic biochips and a custom built thermal cycler, which are also described. The resulting STR profiles can satisfy forensic guidelines for signal strength, inter-loci peak height balance, heterozygous peak height ratio, incomplete non-template nucleotide addition, and stutter. | 2011-12-22 |
20110312615 | MICROFLUIDIC DEVICE WITH PARALLEL NUCLEIC ACID AMPLIFICATION SECTION - A microfluidic device for amplifying nucleic acid sequences, the microfluidic device having an inlet for receiving a sample containing genetic material, a plurality of reagent reservoirs containing reagents for addition to the sample, a first nucleic acid amplification section for amplifying nucleic acid sequences in the genetic material, and, a second nucleic acid amplification section for amplifying nucleic acid sequences in the genetic material in parallel with the first nucleic acid amplification section. | 2011-12-22 |
20110312616 | TEST MODULE WITH PARALLEL DNA AND RNA AMPLIFICATION SECTIONS - A test module for amplifying DNA and RNA, the test module having an outer casing with receptacle for receiving a sample containing genetic material including DNA and RNA, a plurality of reagent reservoirs containing reagents for addition to the sample, a first nucleic acid amplification section for amplifying at least some of the genetic material, and, a second nucleic acid amplification section for amplifying at least some of the genetic material in parallel with the first nucleic acid amplification section. | 2011-12-22 |
20110312617 | MONOLITHIC MICROSYSTEMS TECHNOLOGY DEVICE FOR OLIGONUCLEOTIDE SPOTTING - A microsystems technology (MST) device for contactless spotting of oligonucleotide probes onto a surface, the probes having nucleic acid sequences that are complementary to target nucleic acid sequences to be identified in a biological sample, the MST device having a monolithic substrate having a reservoir side and an ejector side opposite the reservoir side, an array of reservoirs formed in the reservoir side, and, an array of ejectors formed on the ejector side, each of the ejectors being configured for fluid communication with a corresponding one of the reservoirs respectively, wherein, the ejectors are configured to eject droplets containing the oligonucleotide probes from the corresponding reservoir onto the surface. | 2011-12-22 |
20110312618 | OLIGONUCLEOTIDE SPOTTING DEVICE WITH HIGH SPOTTING RATE - An oligonucleotide spotting device for contactless spotting of probes onto a surface, the probes having nucleic acid sequences that are complementary to target nucleic acid sequences to be identified in a biological sample, the oligonucleotide spotting device having an array of ejectors, each having an actuator for ejecting droplets of liquid containing the probes, CMOS circuitry for providing each of the actuators with a drive pulse for droplet ejection, wherein during use, the array of ejectors spot the probes onto the surface at a rate greater than 100 probe spots per second. | 2011-12-22 |
20110312619 | DEVICE FOR HIGH-DENSITY DEPOSITION OF BIOCHEMICALS - A biochemical deposition device for contactless deposition of biochemicals on a surface, the biochemical deposition device having a supporting substrate, an array of reservoirs on one side of the substrate, the reservoirs being configured for containing a plurality of biochemicals, and, an array of ejectors on the other side of the supporting substrate, the ejectors being in fluid communication with the reservoirs, and configured to eject droplets containing the biochemicals onto the surface with a density greater than 1 droplet per square millimeter. | 2011-12-22 |
20110312620 | SYSTEM FOR VARIABLE MICROARRAY SPOTTING AND GENETIC ANALYSIS - A system for microarray spotting and genetic analysis, the system having containers with probes for hybridization with different target nucleic acid sequences, an integrated circuit secured to each of the containers respectively, each of the integrated circuits have a container digital memory storing probe specification data related to probes in that container, a microfluidic device for supporting an array of probes selected from the containers, the selected probes corresponding to a desired genetic test assay, the microfluidic device having a device digital memory, an oligonucleotide spotting robot for spotting the selected probes onto the microfluidic device to form the array of probes, the oligonucleotide spotting robot having a control microprocessor for downloading the specification data to the device digital memory, and, a device reader for accessing the specification data from the device digital memory in order to analyze hybridization data from the microfluidic device. | 2011-12-22 |
20110312621 | APPARATUS FOR DISPENSING REAGENTS AND LOADING OLIGONUCLEOTIDE SPOTTING DEVICES - An apparatus for dispensing reagents and loading oligonucleotide spotting devices, the apparatus having a plurality of reagent vials, each with a droplet dispenser, a plurality of oligonucleotide vials, each with a droplet dispenser, a mounting surface for detachably mounting a microfluidic device for movement relative to the reagent vials, and detachably mounting an oligonucleotide spotting device, and, a control processor for operative control of the reagent vials and oligonucleotide vials and movement of the mounting surface relative to the reagent vials and oligonucleotide vials, wherein, the control processor is configured to activate any of the droplet dispensers, move the microfluidic device into registration with the reagent vials and move the oligonucleotide spotting device into registration with the oligonucleotide vials. | 2011-12-22 |
20110312622 | MICROFLUIDIC DEVICE WITH LOW-VOLUME HYBRIDIZATION CHAMBERS FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET SEQUENCES - A microfluidic device for detecting target nucleic acid sequences in a sample, the microfluidic device having an array of hybridization chambers, each containing electrochemiluminescent (ECL) probes for hybridization with the target nucleic acid sequences, and electrode pairs for receiving an electrical pulse, the ECL probes being configured to emit a photon of light when hybridized with one of the nucleic acid targets and activated by one of the electrodes, wherein, the hybridization chambers each have a volume less than 900000 cubic microns. | 2011-12-22 |
20110312623 | LOC DEVICE FOR PATHOGEN DETECTION WITH DIALYSIS, THERMAL LYSIS, NUCLEIC ACID AMPLIFICATION AND PREHYBRIDIZATION FILTERING - A lab-on-a-chip (LOC) device for detecting pathogens in a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a first dialysis section for separating pathogens from larger constituents in the sample, a lysis section downstream of the dialysis section for lysing the pathogens to release genetic material therein, the lysis section having a lysis chamber and a heater for lysing the pathogens while the sample is in the lysis chamber, a nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences in the genetic material, and, a second dialysis section downstream of the nucleic acid amplification section for prehybridization filtration of amplicon produced by the nucleic acid amplification section, the second dialysis section being configured to remove cell debris from the amplicon, wherein, the first dialysis section, the lysis section, the nucleic acid amplification section and the second dialysis section are all supported on the supporting substrate. | 2011-12-22 |
20110312624 | MICROFLUIDIC DEVICE WITH FLOW-CHANNEL STRUCTURE HAVING ACTIVE VALVE FOR CAPILLARY-DRIVEN FLUIDIC PROPULSION WITHOUT TRAPPED AIR BUBBLES - A microfluidic device for processing a fluid sample, the microfluidic device having a first channel configured to fill with the sample by capillary action, a second channel configured to fill with the sample by capillary action, a plurality of fluid connections between the first channel and the second channel, one of the fluid connections having an active valve to arrest the sample flow into the second channel and the remaining fluid connections each being configured to pin a meniscus of the sample that arrests capillary flow between the first channel and the second channel, the fluid connection with the active valve being upstream of the remaining fluid connections, wherein during use, the sample flow into the second channel is initiated by activation of the active valve such that the sample flow in the second channel progressively removes the meniscus at each of the meniscus anchors. | 2011-12-22 |
20110312625 | LOC DEVICE FOR GENETIC ANALYSIS WITH DIALYSIS, CHEMICAL LYSIS AND TANDEM NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating cells larger than a predetermined threshold in the sample from smaller constituents, whereby the cells larger than a predetermined threshold include target cells containing genetic material for analysis, a plurality of reagent reservoirs, a lysis section downstream of the dialysis section for lysing the target cells to release the genetic material therein, the lysis section being in fluid communication with one of the reagent reservoirs containing a lysis reagent for lysing the target cells in the lysis section, a first nucleic acid amplification section downstream of the lysis section for amplifying first nucleic acid sequences in the genetic material, and, a second nucleic acid amplification section downstream of the first nucleic acid amplification section for amplifying second nucleic acid sequences in the amplicon from the first nucleic acid amplification section, wherein, the dialysis section, the lysis section, the first nucleic acid amplification section and the second nucleic acid amplification section are all supported on the supporting substrate. | 2011-12-22 |
20110312626 | TEST MODULE INCORPORATING SPECTROMETER - A test module having an outer casing having a receptacle for receiving a biological sample, an excitation source mounted in the outer casing for sequentially illuminating the biological sample with different wavelengths of light, and, a photosensor positioned to detect the different wavelengths of light transmitted through the biological sample, wherein during use, the photosensor output signal is used to generate a spectrogram for analysis of a characteristic of the biological sample. | 2011-12-22 |
20110312627 | TEST MODULE WITH MICROFLUIDIC DEVICE HAVING LOC AND DIALYSIS DEVICE FOR SEPARATING PATHOGENS FROM OTHER CONSTITUENTS IN A BIOLOGICAL SAMPLE - A test module for concentrating pathogens in a biological sample, the test module having an outer casing with a receptacle for receiving the sample, a dialysis device in fluid communication with the receptacle and configured to separate the pathogens from other constituents in the sample, and, a lab-on-a-chip (LOC) device being in fluid communication with the dialysis device and configured to analyze the pathogens. | 2011-12-22 |
20110312628 | MICROFLUIDIC DEVICE WITH MST LAYER AND OVERLYING CAP - A microfluidic device having a supporting substrate, a microsystems technologies (MST) layer on the supporting substrate, a cap overlying the MST layer, the cap having a plurality of fluidic connections between the cap and the MST layer for fluid flow from the MST layer to the cap and fluid flow from the cap to the MST layer. | 2011-12-22 |
20110312629 | MICROFLUIDIC DEVICE WITH DIALYSIS SECTION HAVING STOMATA TAPERING COUNTER TO FLOW DIRECTION - A microfluidic device for removing cell debris from a biological sample, the microfluidic device having a dialysis section with a large constituent channel and a small constituent channel, and a series of stoma for fluid communication between the large constituent channel and the small constituent channel, the large constituent channel having an upstream end for receiving the biological sample, the biological sample being a liquid carrying a mixture of cell debris and target molecules, the small constituent channel having a downstream end for connection to a hybridization section with an array of probes for reaction with the target molecules to form probe-target complexes, wherein, each of the stoma is tapered in a counter-flow direction such that each have a small opening to the large constituent channel and a large opening to the small constituent channel, the small openings being sized to allow the target molecules to flow into the small constituent channel but retain the cell debris larger than a threshold size in the large constituent channel. | 2011-12-22 |
20110312630 | LOC DEVICE FOR PATHOGEN DETECTION, GENETIC ANALYSIS AND PROTEOMIC ANALYSIS WITH DIALYSIS, CHEMICAL LYSIS, INCUBATION AND TANDEM NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for pathogen detection, genetic analysis and proteomic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a leukocyte dialysis section for dividing the sample into a leukocyte stream, and a pathogen and erythrocyte stream containing cells and sample constituents smaller than a first size threshold, a pathogen dialysis section for dividing the pathogen and erythrocyte stream into an erythrocyte stream and a pathogen stream containing cells and sample constituents smaller than a second size threshold, a leukocyte lysis section downstream of the leukocyte dialysis section for lysing the leukocytes with a lysis reagent to release genetic material and proteins therein, a leukocyte incubation section downstream of the leukocyte lysis section for enzymatic reaction of the genetic material with enzymes, a pathogen lysis section downstream of the pathogen dialysis section for lysing the pathogens with a lysis reagent to release genetic material and proteins therein, a pathogen incubation section downstream of the pathogen lysis section for enzymatic reaction of the genetic material with enzymes, an erythrocyte lysis section downstream of the pathogen dialysis section for lysing the erythrocytes with a lysis reagent to release proteins therein, a first leukocyte nucleic acid amplification section downstream of the leukocyte incubation section for amplifying nucleic acid sequences, a second leukocyte nucleic acid amplification section downstream of the first leukocyte nucleic acid amplification section for amplifying nucleic acid sequences, a first pathogen nucleic acid amplification section downstream of the pathogen incubation section for amplifying nucleic acid sequences, and, a second pathogen nucleic acid amplification section downstream of the first pathogen nucleic acid amplification for amplifying nucleic acid sequences, wherein, the leukocyte dialysis section, the pathogen dialysis section, the leukocyte lysis section, the pathogen lysis section, the leukocyte incubation section, the pathogen incubation section, the first and second leukocyte nucleic acid amplification sections and the first and second pathogen nucleic acid amplification sections are all supported on the supporting substrate. | 2011-12-22 |
20110312631 | GENETIC ANALYSIS LOC WITH NON-SPECIFIC NUCLEIC ACID AMPLIFICATION SECTION AND SUBSEQUENT SPECIFIC AMPLIFICATION OF PARTICULAR SEQUENCES IN A SEPARATE SECTION - A lab-on-a-chip (LOC) device for genetic analysis of a sample containing target nucleic acid sequences, the LOC device having a sample inlet for receiving the sample, a plurality of reagent reservoirs containing dNTP's, primers, polymerase and buffer solution for addition to the sample, a first nucleic acid amplification section for thermal control of the sample to amplify the target nucleic acid sequences, and, a second nucleic acid amplification section for thermal control of amplicon from the first nucleic acid amplification section to further amplify the target nucleic acid sequences. | 2011-12-22 |
20110312632 | MICROFLUIDIC DEVICE WITH PCR SECTION AND DIFFUSION MIXER - A microfluidic device having a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, a reagent reservoir containing a reagent, and, a diffusion mixing section for mixing the nucleic acid sequences with the reagent, the diffusion mixing section having a microchannel defining a tortuous flow-path having a length sufficient for diffusive mixing of the reagent and the sample, wherein during use, the sample flows from the sample inlet to the PCR section via the diffusion mixing section. | 2011-12-22 |
20110312633 | MICROFLUIDIC DEVICE WITH DIALYSIS SECTION - A microfluidic device for dialysis of biological material, the microfluidic device having a sample inlet for receiving a sample of biological material that has constituents of different sizes, a dialysis section for separating smaller constituents from larger constituents, the smaller constituents being smaller than a predetermined size threshold, and the larger constituents being larger than the predetermined size threshold, and, a microsystems technology (MST) layer for separately processing the smaller constituents and/or the larger constituents. | 2011-12-22 |
20110312634 | MICROFLUIDIC DEVICE WITH LAMINAR STRUCTURE - A microfluidic device having a supporting substrate, a microsystems technology (MST) layer overlying the supporting substrate, the MST layer defining MST channels for fluid flow within the MST layer, a cap overlying the MST layer, the cap defining cap channels for fluid flow within the cap and reservoirs for holding a quantity of fluid, wherein, the MST channels and the cap channels are in fluid communication. | 2011-12-22 |
20110312635 | MICROFLUIDIC DEVICE WITH FLOW-CHANNEL STRUCTURE FOR CAPILLARY-DRIVEN FLUIDIC PROPULSION WITHOUT TRAPPED AIR BUBBLES - A microfluidic device for processing a fluid sample, the microfluidic device having a first channel configured to fill with the sample by capillary action, a second channel configured to fill with the sample by capillary action, a plurality of fluid connections between the first channel and the second channel, each of the fluid connections being configured to pin a meniscus of the sample that arrests capillary flow between the first channel and the second channel, a bypass channel between the first channel and the second channel, the bypass channel joining the second channel upstream of the plurality of fluid connections and is configured for uninterrupted capillary driven flow from the first channel to the second channel, wherein during use, flow from the bypass channel reaches the meniscus pinned at each of the fluid connections after the meniscus has formed such that the flow sequentially removes each of the menisci and sample flow from the first channel to the second channel is via the plurality of fluid connections as well as the bypass channel. | 2011-12-22 |
20110312636 | LOC DEVICE WITH DIALYSIS SECTION FOR SEPARATING LEUKOCYTES FROM BLOOD - A lab-on-a-chip (LOC) device to for analyzing leukocytes in a blood sample, the LOC device having a supporting substrate, an inlet for receiving a sample of blood including leukocytes and erythrocytes, a dialysis section for separating at least some of the erythrocytes from the leukocytes, and, a microsystems technology (MST) layer for separately analyzing the leukocytes, wherein, the inlet, the dialysis section and the MST layer are all supported on the supporting substrate. | 2011-12-22 |
20110312637 | LOC DEVICE WITH DIALYSIS SECTION FOR SEPARATING PATHOGENS FROM A BIOLOGICAL SAMPLE - A lab-on-a-chip (LOC) device to separate pathogens from a biological sample for analysis, the LOC device having a supporting substrate, an inlet for receiving the sample including pathogens and other constituents larger than the pathogens, a dialysis section for separating the pathogens into a portion of the sample, and, a microsystems technology (MST) layer for separately analyzing the pathogens, wherein, the inlet, the dialysis section and the MST layer are all supported on the supporting substrate. | 2011-12-22 |
20110312638 | LOC DEVICE FOR PATHOGEN DETECTION AND GENETIC ANALYSIS WITH DIALYSIS AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for pathogen detection and genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a plurality of reagent reservoirs, a dialysis section for separating pathogens and cells larger than a predetermined threshold in the sample from smaller constituents, whereby the pathogens and cells larger than the predetermined threshold contain genetic material for analysis, a nucleic acid amplification section downstream of the dialysis section for amplifying nucleic acid sequences from the genetic material, wherein, the dialysis section and the nucleic acid amplification section are all supported on the supporting substrate. | 2011-12-22 |
20110312639 | LOC DEVICE WITH DIALYSIS SECTION FOR SEPARATING LEUKOCYTES AND PATHOGENS FROM BLOOD - A lab-on-a-chip (LOC) device to separate pathogens and leukocytes from a blood sample for analysis, the LOC device having a sample inlet for receiving the blood including pathogens, leukocytes and other constituents, a dialysis section for separating the pathogens into a first portion of the sample and separating the leukocytes into a second portion of the sample such that the remainder of the sample has constituents smaller than the leukocytes and larger than the pathogens, and, a microsystems technology (MST) layer for analyzing the pathogens and the leukocytes. | 2011-12-22 |
20110312640 | MICROFLUIDIC DEVICE WITH PHOTOSENSOR - A microfluidic device having a supporting substrate, a microsystems technologies (MST) layer for processing a fluid sample, and, a photosensor adjacent the MST layer for detecting photons emitted from the MST layer. | 2011-12-22 |
20110312641 | MICROFLUIDIC DEVICE WITH SAMPLE INLET AND PROBE HYBRIDIZATION SECTION - A microfluidic device for detecting hybridization of probes with target nucleic acid sequences, the microfluidic device having a sample inlet for receiving a fluid sample with target nucleic acid sequences, an array of probes for hybridization with the target nucleic acid sequences, and, a flow-path from the sample inlet to the array, wherein, the flow-path is configured to draw the fluid sample from the sample inlet to the probes by capillary action. | 2011-12-22 |
20110312642 | MICROFLUIDIC DEVICE FOR DETECTION OF NUCLEIC ACID TARGETS WITH ELECTROCHEMILUMINESCENT PROBES - A microfluidic device for detecting a target nucleic acid sequence in a sample, the microfluidic device having a sample inlet for receiving the sample, probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, and, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, wherein, the sample inlet draws the sample along a fluid flow-path leading to the probes by capillary action. | 2011-12-22 |
20110312643 | MICROFLUIDIC DEVICE FOR DETECTION OF HYBRIDIZATION OF NUCLEIC ACID TARGETS - A microfluidic device having a supporting substrate, a microsystems technologies (MST) layer with a hybridization section that has an array of probes for hybridization with target nucleic acid sequences to form probe-target hybrids, and, a photosensor for detecting the probe-target hybrids. | 2011-12-22 |
20110312644 | MICROFLUIDIC DEVICE FOR SIMULTANEOUS DETECTION OF MULTIPLE CONDITIONS IN A PATIENT - A microfluidic device for simultaneous detection of multiple conditions in a patient, the microfluidic device having an inlet for receiving a sample of biological material drawn from the patient, a microsystems technologies (MST) layer with a detection section having an array of probes for reaction with target molecules in the sample to form probe-target complexes, the target molecules being indicative of medical conditions in the patient, and, a photosensor for detecting the probe-target complexes, wherein, the array of probes has more than 1000 probes. | 2011-12-22 |
20110312645 | MICROFLUIDIC DEVICE WITH TEMPERATURE FEEDBACK CONTROLLED HYBRIDIZATION CHAMBERS FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGETS - A microfluidic device for detecting target nucleic acid sequences in a sample, the microfluidic device having a supporting substrate, a microsystems technology (MST) layer overlying the supporting substrate for processing the sample, the MST layer having an array of hybridization chambers, each containing electrochemiluminescent (ECL) probes for hybridization with the target nucleic acid sequences, and electrode pairs for receiving an electrical pulse, the ECL probes being configured to emit a photon of light when hybridized with one of the nucleic acid targets and activated by one of the electrodes, an array of temperature sensors positioned such that at least one of the temperature sensors corresponds to each of the hybridization chambers respectively, and, heaters for heating each of the hybridization chambers, such that, output from the temperature sensors is used for feedback control of the heaters. | 2011-12-22 |
20110312646 | LOC DEVICE FOR SEPARATING CONSTITUENTS OF INTERMEDIATE SIZE FROM LARGER AND SMALLER CONSTITUENTS IN A BIOLOGICAL SAMPLE - A lab-on-a-chip (LOC) device to separate constituents of intermediate size from larger and smaller constituents in a biological sample, the LOC device having an inlet for receiving the biological sample including large constituents sized above an upper threshold, small constituents sized smaller than a lower threshold and intermediate constituents sized between the upper and the lower thresholds, a first channel in fluid communication with the inlet, first apertures sized to correspond to the upper threshold, a second channel in fluid communication with the first channel via the first apertures, second apertures sized to correspond to the lower threshold, a third channel in fluid communication with the second channel via the second apertures, and, a microsystems technology (MST) layer for analyzing the large, intermediate and or small constituents separately, wherein during use, the intermediate and the small constituents flow into the second channel via the first apertures while the large constituents are retained in the first channel, and the small constituents flow into the third channel while the intermediate constituents are retained in the second channel | 2011-12-22 |
20110312647 | MICROFLUIDIC DEVICE WITH TEMPERATURE FEEDBACK CONTROLLED HYBRIDIZATION CHAMBERS - A microfluidic device having a supporting substrate, a microsystems technology (MST) layer overlying the supporting substrate for processing a fluid containing target nucleic acid sequences, the MST layer having an array of hybridization chambers, each containing probes for hybridization with the target nucleic acid sequences, a temperature sensor for sensing the temperature at the array of hybridization chambers, and, a hybridization heater for heating the array of hybridization chambers, wherein during use, output from the temperature sensor is used for feedback control of the hybridization heater. | 2011-12-22 |
20110312648 | MICROFLUIDIC DEVICE FOR GENETIC AND MITOCHONDRIAL ANALYSIS OF A BIOLOGICAL SAMPLE - A microfluidic device for analysis of genetic DNA and mitochondrial DNA in a sample, the microfluidic device having an inlet for receiving a sample of biological material having cells with an outer cellular membrane containing mitochondria and a nucleus, the mitochondria has a mitochondrial membrane containing mitochondrial DNA and the nuclei have a nuclear membrane containing nuclear DNA, a first lysis section for lysing the outer cellular membrane and the mitochondrial membrane while the nuclear membrane remains intact, a second lysis section for lysing the nuclear membrane, mitochondrial probes downstream of the first lysis section for hybridization with target nucleic acid sequences in the mitochondrial DNA to form probe-target hybrids, and, nuclear probes downstream of the second lysis second for hybridization with target nucleic acid sequences in the nuclear DNA to form probe-target hybrids. | 2011-12-22 |
20110312649 | MICROFLUIDIC DEVICE WITH OPTICALLY TRANSPARENT HYBRIDIZATION CHAMBERS - A microfluidic device having a supporting substrate, a microsystems technology (MST) layer overlying the supporting substrate for processing a fluid containing target nucleic acid sequences, the MST layer having an array of hybridization chambers, each containing probes for hybridization with the target nucleic acid sequences, the probes being configured to emit a fluorescence signal in response to an excitation light upon hybridization, wherein, the hybridization chamber has a wall section that is optically transparent to the fluorescence signal. | 2011-12-22 |
20110312650 | MICROFLUIDIC DEVICE WITH OPTICALLY TRANSPARENT HYBRIDIZATION CHAMBERS FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGETS - A microfluidic device for detecting target nucleic acid sequences in a sample, the microfluidic device having an array of hybridization chambers, each containing electrochemiluminescent (ECL) probes for hybridization with the target nucleic acid sequences, and electrode pairs for receiving an electrical pulse, the ECL probes being configured to emit a photon of light when hybridized with one of the nucleic acid targets and activated by one of the electrodes, wherein, the hybridization chambers each have a wall section that is optically transparent to the light emitted by the ECL probes. | 2011-12-22 |
20110312651 | MICROFLUIDIC DEVICE WITH LOW MASS PROBE SPOTS - A microfluidic device having a supporting substrate, a microsystems technology (MST) layer overlying the supporting substrate for processing a fluid containing target nucleic acid sequences, the MST layer having a plurality of probe spots, each of the probe spots containing probes for hybridization with the target nucleic acid sequences, wherein, the mass of the probes in each of the probe spots is less than 270 picograms. | 2011-12-22 |
20110312652 | MICROFLUIDIC DEVICE WITH LOW-VOLUME ELECTROCHEMILUMINESCENCE-BASED PROBE SPOTS - A microfluidic device for detecting target nucleic acid sequences in a sample, the microfluidic device having an array of hybridization chambers, each of the hybridization chambers containing electrode pairs for receiving an electrical pulse and electrochemiluminescent (ECL) probes for hybridization with the target nucleic acid sequences, the ECL probes being configured to emit a photon of light when hybridized with one of the nucleic acid targets and excited by current between the electrodes, wherein, the mass of the probes in each of the hybridization chambers is less than 270 picograms. | 2011-12-22 |
20110312653 | MICROFLUIDIC DEVICE WITH LOW-VOLUME HYBRIDIZATION CHAMBERS - A microfluidic device having a supporting substrate, a microsystems technologies (MST) layer with a hybridization section that has an array of hybridization chambers, each containing a different probe type for hybridization with target nucleic acid sequences, wherein, each of the hybridization chambers has a volume less than 900,000 cubic microns. | 2011-12-22 |
20110312654 | APPARATUS FOR LOADING OLIGONUCLEOTIDE SPOTTING DEVICES AND SPOTTING OLIGONUCLEOTIDE PROBES - An apparatus for loading oligonucleotide spotting devices and spotting oligonucleotide probes, the apparatus having a plurality of oligonucleotide vials, each with a droplet dispenser, a mounting surface for detachably mounting an oligonucleotide spotting device, a chuck for detachably mounting the oligonucleotide spotting device adjacent the mounting surface, and, a control processor for operative control of the oligonucleotide vials, the oligonucleotide spotting device when mounted in the chuck and movement of the mounting surface relative to the oligonucleotide vials, and the oligonucleotide spotting device, wherein, the control processor is configured to activate the droplet dispensers, and move the oligonucleotide spotting device into registration with the oligonucleotide vials. | 2011-12-22 |
20110312655 | MICROFLUIDIC DEVICE FOR PCR, PROBE HYBRIDIZATION AND ELECTROCHEMILUMINESCENT DETECTION OF PROBE-TARGET HYBRIDS - A microfluidic device for amplifying and detecting target nucleic acid sequences in a sample, the microfluidic device having a polymerase chain reaction (PCR) section for amplifying the target nucleic acid sequences, and, a hybridization section that has an array of electrochemiluminescent (ECL) probes for hybridization with the target nucleic acid sequences to form probe-target hybrids, and a plurality of electrodes for receiving an electrical pulse such that the probe-target hybrids emit a photon of light. | 2011-12-22 |
20110312656 | MICROFLUIDIC DEVICE FOR PCR AND PROBE HYBRIDIZATION - A microfluidic device having a sample inlet for receiving a sample of biological material containing target nucleic acid sequences, and, a microsystems technologies (MST) layer with a polymerase chain reaction (PCR) section for amplifying the target nucleic acid sequences, and an array of probes for hybridization with the target nucleic acid sequences. | 2011-12-22 |
20110312657 | MICROFLUIDIC TEST MODULE FOR INTERFACING WITH A MOBILE TELEPHONE - A microfluidic test module for analyzing a sample fluid and communicating test results to a mobile telephone, the microfluidic test module having an outer casing with a receptacle for receiving the sample, functional sections for processing and analyzing the sample, a communication interface for communication with the mobile telephone, and, a controller for operative control of the communication interface. | 2011-12-22 |
20110312658 | LOC DEVICE WITH DIALYSIS SECTION FOR CONCENTRATING NUCLEATED CELLS IN A BIOLOGICAL SAMPLE - A lab-on-a-chip (LOC) device for concentrating nucleated cells in a biological sample, the LOC device having an inlet for receiving a sample of biological material including nucleated cells and other constituents, the nucleated cells all being larger than a predetermined threshold, a dialysis section for concentrating the nucleated cells into a portion of the sample such that the remainder of the sample contains the other constituents smaller than the predetermined threshold, and, a microsystems technology (MST) layer for processing the nucleated cells. | 2011-12-22 |
20110312659 | MICROFLUIDIC DEVICE WITH HYBRIDIZATION CHAMBERS AND CORRESPONDING DIFFUSION BARRIERS - A microfluidic device having a sample flow-path for a biological sample containing target nucleic acid sequences, an array of hybridization chambers each containing probes for hybridization with the target nucleic acid sequences, each of the hybridization chambers having a chamber inlet for fluid communication between the sample flow-path and the probes, wherein, the chamber inlet is configured as a diffusion barrier to prevent diffusion of hybridized probes between the hybridization chambers to an extent that causes erroneous hybridization detection results. | 2011-12-22 |
20110312660 | MICROFLUIDIC TEST MODULE FOR INTERFACING WITH A LAPTOP COMPUTER - A microfluidic test module for analyzing a sample fluid and communicating test results to a laptop computer, the microfluidic test module having an outer casing with a receptacle for receiving the sample, functional sections for processing and analyzing the sample, a communication interface for communication with the laptop computer, and, a controller for operative control of the communication interface. | 2011-12-22 |
20110312661 | MICROFLUIDIC DEVICE WITH ARRAY OF CHAMBERS AND CORRESPONDING DIFFUSION BARRIERS FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGETS - A microfluidic device for detecting target molecules in a fluid, the microfluidic device having an array of chambers, each containing electrochemiluminescent (ECL) probes for reaction with the target molecules to form a probe-target complex, and electrodes positioned in each of the chambers for receiving an electrical pulse, the probe-target complexes being configured to emit a photon of light when excited by current between the electrodes, a flow-path for the fluid containing the targets, wherein, each of the chambers have a chamber inlet for fluid communication between the sample flow-path and the probes within the chamber, the chamber inlet being configured as a diffusion barrier to prevent diffusion of the probe-target complexes between the chambers to an extent that causes erroneous detection results. | 2011-12-22 |
20110312662 | LOC DEVICE WITH DIALYSIS SECTION FOR REMOVING CELL DEBRIS FROM A BIOLOGICAL SAMPLE - A lab-on-a-chip (LOC) device for removing cell debris from a biological sample, the LOC device having a dialysis section with a large constituent channel, a small constituent channel and a plurality of apertures for fluid communication between the large constituent channel and the small constituent channel, the large constituent channel having an upstream end for receiving the biological sample, the biological sample being a liquid carrying a mixture of cell debris and target molecules, the small constituent channel having a downstream end for connection to a hybridization section with an array of probes for reaction with the target molecules to form probe-target complexes, wherein, the apertures are sized to allow the target molecules to flow into the small constituent channel but retain the cell debris larger than a threshold size in the large constituent channel. | 2011-12-22 |
20110312663 | MICROFLUIDIC DEVICE WITH TIME DELAYED DETECTION OF FLUORESCENCE FROM HYBRIDIZED PROBES - A microfluidic device having a supporting substrate, a probe having a nucleic acid sequence for hybridization with a target nucleic acid sequence to form a probe-target hybrid, the probe-target hybrid being configured to generate a fluorescence signal in response to an excitation light, and, CMOS circuitry on the substrate, the CMOS circuitry having a photosensor for generating an output signal in response to the fluorescence signal, wherein, the CMOS circuitry is configured to trigger a time delay when the excitation light is deactivated before activating the photosensor. | 2011-12-22 |
20110312664 | MICROFLUIDIC TEST MODULE FOR INTERFACING WITH A DEDICATED READER - A microfluidic test module for analyzing a sample fluid and communicating test results to a dedicated reader purpose built for operating with the microfluidic test module, the microfluidic test module having an outer casing with a receptacle for receiving the sample, functional sections for processing and analyzing the sample, a communication interface for communication with the dedicated reader, and, a controller for operative control of the communication interface. | 2011-12-22 |
20110312665 | LOC WITH DIALYSIS SECTION FOR REMOVING INSOLUBLE SAMPLE CONSTITUENTS FROM A NUCLEIC ACID MIXTURE - A lab-on-a-chip (LOC) device for removing cell debris from a biological sample containing target nucleic acid sequences, the LOC device having a dialysis section with a large constituent channel, a small constituent channel and a plurality of apertures for fluid communication between the large constituent channel and the small constituent channel, the large constituent channel having an upstream end for receiving the biological sample, the biological sample being a liquid carrying a mixture of cell debris and target nucleic acid sequences, and the small constituent channel having a downstream end for connection to a hybridization section with an array of probes for hybridization with the target nucleic acid sequences to form probe-target complexes, wherein, the apertures are sized to allow the target nucleic acid sequences to flow into the small constituent channel but retain the cell debris larger than a threshold size in the large constituent channel. | 2011-12-22 |
20110312666 | MICROFLUIDIC DEVICE WITH TRIGGERED PHOTODETECTION OF FLUORESCING PROBE-TARGET HYBRID - A microfluidic device having a probe for hybridization with a target nucleic acid sequence to form a probe-target hybrid, the probe-target hybrid having a reporting fluorophore for emitting a fluorescence signal in response to an excitation light, a detection photodiode for exposure to the excitation light and the fluorescence signal, and, a trigger photodiode for exposure to the excitation light, the trigger photodiode being configured to activate the detection photodiode after the excitation light has been extinguished. | 2011-12-22 |
20110312667 | MICROFLUIDIC TEST MODULE FOR INTERFACING WITH A DESKTOP COMPUTER - A microfluidic test module for analyzing a sample fluid and communicating test results to a desktop computer, the microfluidic test module having an outer casing with a receptacle for receiving the sample, functional sections for processing and analyzing the sample, a communication interface for communication with the desktop computer, and, a controller for operative control of the communication interface. | 2011-12-22 |
20110312668 | LOC WITH DIALYSIS SECTION FOR RETAINING INSOLUBLE SAMPLE CONSTITUENTS AFTER AMPLIFICATION AND PASSING SOLUBLE CONSTITUENTS TO A DETECTION SECTION - A lab-on-a-chip (LOC) device for removing cell debris from a biological sample containing target nucleic acid sequences, the LOC device having an amplification section for amplifying the nucleic acid sequences, a dialysis section with a large constituent channel, a small constituent channel and a plurality of apertures for fluid communication between the large constituent channel and the small constituent channel, the large constituent channel configured to receive the biological sample after nucleic acid amplification in the amplification section, the biological sample being a liquid mixture of the cell debris and the target nucleic acid sequences and the apertures are sized to allow the target nucleic acid sequences to flow into the small constituent channel while the cell debris larger than a threshold size is retained in the large constituent channel, and, an array of probes in fluid communication with the small constituent channel for hybridization with the target nucleic acid sequences to form probe-target hybrids. | 2011-12-22 |
20110312669 | MICROFLUIDIC DEVICE WITH ELECTROCHEMILUMINESCENT PROBES AND PHOTOSENSOR WITH LARGE ANGLE OF COLLECTION FOR PROBE EMITTTED LIGHT - A microfluidic device for detecting target molecules in a fluid, the microfluidic device having a hybridization chamber containing electrodes and probes for hybridization with target molecules to form probe-target complexes and generate an electrochemiluminescence (ECL) signal in response to an electrical current between the electrodes, and, a photodiode with an active area and an optical axis extending normal to the active area and through the hybridization chamber, wherein, the hybridization chamber has a floor surface positioned parallel to the active area of the photodiode, the floor surface having a centroid and the active area being encompassed within a cone having the centroid at its vertex, and a vertex angle less than 174°. | 2011-12-22 |
20110312670 | MICROFLUIDIC TEST MODULE FOR INTERFACING WITH AN EBOOK READER - A microfluidic test module for analyzing a sample fluid and communicating test results to an ebook reader, the microfluidic test module having an outer casing with a receptacle for receiving the sample, functional sections for processing and analyzing the sample, a communication interface for communication with the ebook reader, and, a controller for operative control of the communication interface. | 2011-12-22 |
20110312671 | SINGLE USE MICROFLUIDIC DEVICE WITH PHOTOSENSOR FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGETS - A microfluidic device for detecting target molecules in a fluid, the microfluidic device having an array of electrochemiluminescent (ECL) probes for reaction with the target molecules to form a probe-target complexes, electrodes for receiving an electrical pulse, the probe-target complexes being configured to emit a photon of light when excited by current between the electrodes, and, a photosensor for detecting the light emitted by the probes, wherein during use, addition of the fluid to the probes prevents subsequent addition of other fluid to the probes. | 2011-12-22 |
20110312672 | MICROFLUIDIC ASSEMBLY WITH TEST MODULE AND DETACHABLE INDICATOR MODULE - A microfluidic assembly for detecting a target molecule in a sample fluid and indicating a positive or negative result, the microfluidic assembly having a test module having an outer casing with a receptacle for receiving the sample, functional sections for processing the sample and detecting the target molecules, a communication interface a controller for transmitting an output signal from one or more of the functional sections, and, an indicator module for detachable engagement with the communication interface, the indicator module having an indicator for providing an indication of the target molecule being present in the fluid sample. | 2011-12-22 |
20110312673 | DIALYSIS DEVICE WITH MULTI-LAYER STRUCTURE - A dialysis device for dialysis of a fluid containing constituents of different sizes, the dialysis device having a first layer of material defining a first channel and a second channel, the first channel configured for receiving the fluid which contains constituents of different sizes, a second layer having a plurality of apertures open to the first channel and at least one fluid connection leading from the apertures to the second channel for establishing fluid communication between the first channel and the second channel, wherein, the apertures are sized in accordance with a predetermined size threshold such that the constituents flowing to the second channel are smaller constituents that are smaller than the predetermined size threshold, and the constituents retained in the first channel include larger constituents which are larger than the predetermined size threshold. | 2011-12-22 |
20110312674 | LOC DEVICE WITH INTEGRAL PHOTOSENSOR FOR ELECTROCHEMILUMINESCENCE BASED DETECTION OF TARGETS - A lab-on-a-chip (LOC) device for detecting target molecules in a fluid, the LOC device having an array of electrochemiluminescent (ECL) probes for reaction with the target molecules to form probe-target complexes, electrodes for receiving an electrical pulse, the probe-target complexes being configured to emit a photon of light when excited by current between the electrodes, and, a photosensor for detecting light emitted by the probe-target complexes. | 2011-12-22 |
20110312675 | DIALYSIS DEVICE WITH FLOW-CHANNEL STRUCTURE FOR CAPILLARY-DRIVEN FLUIDIC PROPULSION WITHOUT TRAPPED AIR BUBBLES - A dialysis device with capillary-driven, flow-channel structure for dialysis of a fluid containing constituents of different sizes, the dialysis device having a first channel configured to fill with the fluid by capillary action, a second channel configured to fill with the fluid by capillary action, a plurality of fluid connections between the first channel and the second channel, each of the fluid connections being configured to pin a meniscus of the fluid that arrests capillary flow between the first channel and the second channel, a bypass channel between the first channel and the second channel, the bypass channel joining the second channel upstream of the plurality of fluid connections and is configured for uninterrupted capillary driven flow from the first channel to the second channel, wherein during use, flow from the bypass channel reaches the meniscus pinned at each of the fluid connections after the meniscus has formed such that the flow sequentially removes each of the menisci and sample flow from the first channel to the second channel is via the plurality of fluid connections as well as the bypass channel. | 2011-12-22 |
20110312676 | LOC DEVICE WITH INTEGRAL DRIVER FOR EXCITATION OF ELECTROCHEMILUMINESCENT LUMINOPHORES - A lab-on-a-chip (LOC) device for exciting electrochemiluminescent luminophores, the LOC device having a supporting substrate, an array of electrochemiluminescent (ECL) probes for reaction with the target molecules to form probe-target complexes, the probes each having a luminophore for emitting photons of light when in an excited state, electrodes for receiving an electrical pulse to excite the luminophores with current between the electrodes, and, CMOS circuitry for controlling the electrical pulse transmitted to the electrodes, wherein, the CMOS circuitry is between the supporting substrate and the array of probes. | 2011-12-22 |
20110312677 | LOC DEVICE FOR DETECTION OF TARGETS WITH ELECTROCHEMILUMINESCENT RESONANT ENERGY TRANSFER PROBES - A lab-on-a-chip (LOC) device for detecting target molecules in a fluid, the LOC device having an array of electrochemiluminescent (ECL) probes for reaction with the target molecules to form probe-target complexes, and, electrodes for receiving an electrical pulse, wherein, the probes each have an ECL luminophore that emits a photon when excited by current between the electrodes, and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer. | 2011-12-22 |
20110312678 | TEST MODULE WITH MICROFLUIDIC DEVICE HAVING DIALYSIS DEVICE, LOC AND INTERCONNECTING CAP - A test module for analyzing a sample fluid containing target molecules, the test module having an outer casing with a receptacle for receiving the sample fluid, and, a microfluidic device having: a dialysis device in fluid communication with the receptacle and configured to separate the target molecules from other constituents of the sample, a lab-on-a-chip (LOC) device for analyzing the target molecules, and, a cap overlaying the LOC device and the dialysis device for establishing fluid communication between the LOC device and the dialysis device. | 2011-12-22 |
20110312679 | MICROFLUIDIC DEVICE WITH SURFACE-MICROMACHINED DIALYSIS SECTION - A microfluidic device for removing cell debris from a biological sample, the microfluidic device having a dialysis section with a large constituent channel, a small constituent channel and a plurality of apertures for fluid communication between the large constituent channel and the small constituent channel, the large constituent channel having an upstream end for receiving the biological sample, the biological sample being a liquid carrying a mixture of cell debris and target molecules, the small constituent channel having a downstream end for connection to a hybridization section with an array of probes for reaction with the target molecules to form probe-target complexes, wherein, the apertures are spaced along the large constituent channel at a spacing between 1 micron and 10 microns and each of the apertures is sized to allow the target molecules to flow into the small constituent channel but retain the cell debris larger than a threshold size in the large constituent channel. | 2011-12-22 |
20110312680 | LOC DEVICE FOR DETECTING HYBRIDIZATION OF TARGET NUCLEIC ACID SEQUENCES WITH ELECTROCHEMILUMINESCENT RESONANT ENERGY TRANSFER, PRIMER-LINKED, LINEAR PROBES - A lab-on-a-chip (LOC) device for detecting hybridization of target nucleic acid sequences, the LOC device having electrochemiluminescent (ECL), resonant energy transfer, primer-linked, linear probes for hybridization with the target nucleic acid sequences to form probe-target hybrids, each of the probes having a linear portion containing the target nucleic acid sequence, a primer for extension along the target nucleic acid sequence to form a nucleic acid sequence complementary to the target, an ECL luminophore for emitting photons when in an excited state, and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, and, electrodes for receiving an electrical pulse to excite the ECL luminophores, wherein during use, replicating the target nucleic acid sequence causes the linear portion to dissociate from the functional moiety such that the complementary nucleic acid sequence therein hybridizes to the target nucleic acid sequence and photons emitted by the ECL luminophore are not quenched. | 2011-12-22 |
20110312681 | LOC DEVICE WITH DIALYSIS SECTION FOR REMOVING ERYTHROCYTES FROM BLOOD - A lab-on-a-chip (LOC) device for analyzing leukocytes in a blood sample, the LOC device having a supporting substrate, an inlet for receiving a sample of blood, a dialysis section for separating erythrocytes from leukocytes in the blood, and, a microsystems technology (MST) layer for analyzing the leukocytes, wherein, the inlet, the dialysis section and the MST layer are all supported on the supporting substrate. | 2011-12-22 |
20110312682 | LOC DEVICE FOR AMPLIFYING AND DETECTING TARGET NUCLEIC ACID SEQUENCES USING ELECTROCHEMILUMINESCENT RESONANT ENERGY TRANSFER, STEM-AND-LOOP PROBES WITH COVALENTLY ATTACHED PRIMERS - A lab-on-a-chip (LOC) device for amplifying and detecting target nucleic acid sequences, the LOC device having electrochemiluminescent (ECL), resonant energy transfer, stem-and-loop probes for hybridization with the target nucleic acid sequences, each of the probes having a loop portion containing a sequence complementary to the target nucleic acid sequence, an ECL luminophore for emitting photons when in an excited state, a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, and a covalently attached primer for extension along a complementary sequence denatured from the target nucleic acid sequence to replicate the target nucleic acid sequence, heaters for thermally cycling the target nucleic acid sequences through a polymerase chain reaction (PCR), in which the covalently attached primers anneal to oligonucleotides containing the target nucleic acid sequences, and, electrodes for receiving an electrical pulse to excite the ECL luminophores, wherein during use, replicating the target nucleic acid sequence causes the loop portion to open such the complementary nucleic acid sequence therein hybridizes to the target nucleic acid sequence and the ECL luminophore is moved away from the functional moiety. | 2011-12-22 |
20110312683 | MICROFLUIDIC TEST MODULE FOR INTERFACING WITH TABLET COMPUTER - A microfluidic test module for analyzing a sample fluid and communicating test results to a tablet computer, the microfluidic test module having an outer casing with a receptacle for receiving the sample, functional sections for processing and analyzing the sample, a communication interface for communication with the tablet computer, and, a controller for operative control of the communication interface. | 2011-12-22 |
20110312684 | LOC DEVICE FOR PATHOGEN DETECTION WITH DIALYSIS, LYSIS AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for detecting pathogens in a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating pathogens from larger constituents in the sample, a lysis section downstream of the dialysis section for lysing the pathogens to release genetic material therein, and, a nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences in the genetic material, wherein, the dialysis section, the lysis section and the nucleic acid amplification section are all supported on the supporting substrate. | 2011-12-22 |
20110312685 | LOC DEVICE FOR PCR USING ADAPTOR PRIMERS AND TARGET DETECTION USING ELECTROCHEMILUMINESCENT RESONANT ENERGY TRANSFER PROBES - A lab-on-a-chip (LOC) device for amplifying and detecting target nucleic acid sequences, the LOC device having restriction enzymes for restricting double stranded oligonucleotides at known ligation sites, linker molecules for attaching to the ligated ends of the double stranded oligonucleotides, heaters for thermally cycling the oligonucleotides through a polymerase chain reaction (PCR) process, primers for annealing to the linker molecules on single strands of the oligonucleotides after denaturation, deoxyribonucleoside triphosphates (dNTPs) for extending the primers along the single strand oligonucleotides, and, electrodes for receiving an electrical pulse to excite the ECL luminophores. | 2011-12-22 |
20110312686 | MICROFLUIDIC DEVICE WITH ELONGATE PCR CHAMBERS - A microfluidic device having a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having at least one elongate PCR chamber having a longitudinal extent much greater than its lateral dimensions, and, at least one elongate heater element for heating the nucleic acid sequences within the elongate PCR chamber, wherein, the elongate heater element extends parallel with the longitudinal extent of the PCR chamber. | 2011-12-22 |
20110312687 | LOC DEVICE WITH LOW VOLUME HYBRIDIZATION CHAMBERS AND REAGENT RESERVOIRS FOR GENETIC ANALYSIS USING ELECTROCHEMILUMINESCENT TARGET DETECTION - A lab-on-a-chip (LOC) device for detecting target nucleic acid sequences in a fluid, the LOC device having electrochemiluminescent (ECL), resonance energy transfer probes for hybridization with the target nucleic acid sequences, each of the probes containing a sequence complementary to the target nucleic acid sequence, and an ECL luminophore for emitting photons when in an excited state, a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, electrodes for receiving an electrical pulse to excite the ECL luminophores, hybridization chambers containing the probes for hybridization with the targets, at least one of the heaters and a pair of the electrodes, and, a reagent reservoir containing a reagent for addition to the fluid, wherein, the hybridization chambers each have a volume less than 900,000 cubic microns and the reagent reservoir has a volume less than 1,000,000,000 cubic microns. | 2011-12-22 |
20110312688 | MICROFLUIDIC DEVICE WITH PCR CHAMBER BETWEEN SUPPORTING SUBSTRATE AND HEATER - A microfluidic device having a supporting substrate, a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having a PCR chamber, and, a heater element for heating the nucleic acid sequences within the PCR chamber, wherein, the PCR chamber is between the heater element and the supporting substrate. | 2011-12-22 |
20110312689 | MICROFLUIDIC DEVICE WITH SENSOR-TRIGGERED PHOTODETECTION OF FLUORESCENT PROBE-TARGET HYBRID - A microfluidic device having a supporting substrate, an array of probes, each of the probes having a nucleic acid sequence for hybridization with a target nucleic acid sequence to form a probe-target hybrid, the probe-target hybrid being configured to generate a fluorescence signal in response to an excitation light, and, CMOS circuitry on the substrate, the CMOS circuitry having an array of photodiodes for sensing deactivation of the excitation light and generating an output signal in response to the fluorescence signals from the probe-target hybrids within the array of probes. | 2011-12-22 |
20110312690 | MICROFLUIDIC DEVICE WITH PCR SECTION HAVING TWO-DIMENSIONAL CONTROL OF INPUT HEAT FLUX DENSITY - A microfluidic device having a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having a microchannel configured to have a plurality of mutually parallel, adjacent channel sections, and a plurality of elongate heaters positioned end to end along each of the channel sections, wherein, each of the heaters are independently operable for two-dimensional control of heat flux density to the PCR section. | 2011-12-22 |
20110312691 | LOC DEVICE WITH ELECTROCHEMILUMINESCENT PROBES INCLUDING POSITIVE AND NEGATIVE CONTROL PROBES - A lab-on-a-chip (LOC) device for detecting target nucleic acid sequences in a fluid, the LOC device having electrochemiluminescent (ECL) probes for detecting the target nucleic acid sequences, each of the probes having an ECL luminophore for emitting photons when in an excited state, a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, at least one positive control probe that has one of the ECL luminophores but not the functional moiety for quenching photon emission, at least one negative control probe that does not have one of the ECL luminophores, and, electrodes for receiving an electrical pulse to excite the ECL luminophores. | 2011-12-22 |
20110312692 | LOC DEVICE FOR PATHOGEN DETECTION WITH DIALYSIS, THERMAL LYSIS AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for detecting pathogens in a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating pathogens from larger constituents in the sample, a lysis section downstream of the dialysis section for lysing the pathogens to release genetic material therein, the lysis section having a lysis chamber and a heater for lysing the pathogens while the sample is in the lysis chamber, and, a nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences in the genetic material, wherein, the dialysis section, the lysis section and the nucleic acid amplification section are all supported on the supporting substrate. | 2011-12-22 |
20110312693 | MICROFLUIDIC DEVICE WITH FEEDBACK CONTROLLED PCR SECTION - A microfluidic device having a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having at least one heater, and, at least one sensor, wherein, the at least one sensor is configured to provide output for feedback control of the at least one heater. | 2011-12-22 |
20110312694 | MICROFLUIDIC DEVICE WITH DELAY-TRIGGERED PHOTODETECTION OF FLUORESCENT PROBE-TARGET HYBRID - A microfluidic device having a supporting substrate, a probe having a nucleic acid sequence for hybridization with a target nucleic acid sequence to form a probe-target hybrid, the probe-target hybrid being configured to generate a fluorescence signal in response to an excitation light, and, CMOS circuitry on the substrate, the CMOS circuitry having a photosensor for generating an output signal in response to the fluorescence signal, wherein, the CMOS circuitry is configured to initiate a time delay upon deactivation of the excitation light before activating the photosensor. | 2011-12-22 |
20110312695 | LOC DEVICE WITH HYBRIDIZATION CHAMBER ARRAY WITH POSITIVE CONTROL CHAMBER CONTAINING ELECTROCHEMILUMINESCENT REPORTER - A lab-on-a-chip (LOC) device for detecting target nucleic acid sequences in a fluid, the LOC device having electrochemiluminescent (ECL) probes for detecting the target nucleic acid sequences, each of the probes having an ECL luminophore for emitting photons when in an excited state, a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, electrodes for receiving an electrical pulse to excite the ECL luminophores, hybridization chambers containing the probes for detection of the targets, and a pair of the electrodes, and, at least one positive control chamber containing positive control probes that have the ECL luminophore but not the functional moiety for quenching photon emission. | 2011-12-22 |
20110312696 | LOC DEVICE FOR PATHOGEN DETECTION WITH DIALYSIS, CHEMICAL LYSIS AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for detecting pathogens in a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating pathogens from larger constituents in the sample, a plurality of reagent reservoirs, a lysis section downstream of the dialysis section for lysing the pathogens to release genetic material therein, the lysis section being in fluid communication with one of the reagent reservoirs containing a lysis reagent for lysing the cells in the lysis section, and, a nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences in the genetic material, wherein, the dialysis section, the lysis section and the nucleic acid amplification section are all supported on the supporting substrate. | 2011-12-22 |
20110312697 | MICROFLUIDIC DEVICE WITH TEMPERATURE FEEDBACK CONTROLLED PCR SECTION - A microfluidic device having a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having at least one heater, and, at least one temperature sensor, wherein, the at least one temperature sensor is configured to provide output for feedback control of the at least one heater. | 2011-12-22 |
20110312698 | MICROFLUIDIC DEVICE WITH PCR SECTION HAVING SHORT THERMAL CYCLE TIMES - A microfluidic device having a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having at least one heater for thermally cycling the nucleic acid sequences through a denaturation phase, an annealing phase and a primer extension phase, wherein during use, the PCR section has a thermal cycle time of less than 30 seconds. | 2011-12-22 |
20110312699 | MICROFLUIDIC DEVICE WITH ON-CHIP SEMICONDUCTOR CONTROLLED PCR SECTION - A microfluidic device having a supporting substrate, a sample inlet for receiving a sample of biological material having nucleic acid sequences, a microsystems technology (MST) layer having a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having at least one heater for thermally cycling the nucleic acid sequences through a denaturation phase, an annealing phase and a primer extension phase, and, CMOS circuitry between the MST layer and the supporting substrate, the CMOS circuitry being connected to the at least one heater for operative control of the at least one heater during the thermal cycling. | 2011-12-22 |