51st week of 2011 patent applcation highlights part 41 |
Patent application number | Title | Published |
20110311999 | DIAGNOSTIC PREDICTION OF RHEUMATOID ARTHRITIS AND SYSTEMIC LUPUS ERYTHEMATOSUS - The present invention pertains to a diagnostic assay for the diagnosis of an autoimmune disease. The present invention provides an improved diagnostic assay for the diagnosis of an autoimmune disease, particularly rheumatoid arthritis (RA) and Systemic Lupus Erythematosus (SLE). In particular the invention pertains to a method of determining in a sample of a subject the presence of two or more antibodies comprising the step of determining whether an antibody is present in a sample that specifically recognizes a hnRNP-DL polypeptide or a fragment thereof or a splice variant thereof and the further step of determining whether at least one further antibody is present in the sample that specifically recognizes a at least one other hnRNP polypeptide which is not sequence homologue to said hnRNP-DL polypeptide or fragments thereof or splice variants thereof, and/or said CCP peptide and/or a polypeptide comprising at least the Fc-part of IgG, respectively. The invention also relates to polypeptides, protein sets and antibodies that may be used in such methods and assays and for therapeutic use in RA and SLE patients. | 2011-12-22 |
20110312000 | MONOCLONAL ANTIBODY AND USE THEREOF - The purpose of the invention is to provide an antibody which recognizes OPN N-half but does not recognize the full-length OPN, and its use. A monoclonal antibody which is characterized in that it recognizes a protein or polypeptide in which the C-terminal amino acid sequence is YGLR (SEQ ID NO: 1) and it substantially does not recognize a protein or polypeptide which has an amino acid sequence of YGLR outside of the C-terminal, as well as a method for measuring OPN N-half utilizing the said antibody, a method for diagnosing diseases relating to OPN N-half, a method for judging the severity of said disease, and a method for treating said diseases, are provided. | 2011-12-22 |
20110312001 | COMPENDIUM OF READY-BUILT STEM CELL MODELS FOR INTERROGATION OF BIOLOGICAL RESPONSE - The invention generally features methods for providing engineered pluripotent stem cells that can be used to study biological response and pathways, including differentiation and drug effects. For example, these cells are provided comprising two or more exogenous expression cassettes including a selectable or screenable marker under the control of different condition-responsive regulatory elements, such as differentiation-responsive promoters or regulatory element of a receptor, drug target, drug metabolizing enzyme or signaling pathway gene. Also provided are sets of stem cell lines each comprising a different exogenous expression cassette including a selectable or screenable marker under the control of a different condition-responsive regulatory element. | 2011-12-22 |
20110312002 | NMR DETECTION OF COAGULATION TIME - The invention relates to detecting coagulation and coagulation-related activities including agglutination and fibrinolysis of samples. More particularly the invention relates to methods and apparatus for monitoring coagulation and/or obtaining a coagulation time of a sample using NMR-based detectors. | 2011-12-22 |
20110312003 | DETERMINING PERFORMANCE CHARACTERISTICS OF A FERMENTER BATCH OF A BIOFUEL PRODUCTION PLANT - A method for determining performance characteristics of a fermenter batch in a biofuel production plant based on stoichiometry of fermentation reactions, comprising determining a cell mass of a sample of the fermenter batch; a glucose equivalent total (GET) based at least on the cell mass of the sample of the fermenter batch, and a starch to glucose conversion factor (SGCF) based at least on the GET; a total amount of glucose based at least on the SGCF, a volume of ethanol based at least on the total amount of glucose and the GET; at least one of a fermenter yield based at least on the volume of ethanol, and a fermenter efficiency based on the fermenter yield or the volume of ethanol; and generating an output based on the fermenter yield and/or the fermenter efficiency. | 2011-12-22 |
20110312004 | TEST STRIP WITH MAGNETO-ELASTIC-RESONANCE SENSOR - A test meter system for testing a characteristic of a fluid, the test meter system including a test meter having a housing with an opening adapted to accept a test strip, an interrogation coil within the housing, a pick-up coil within the housing, and a test strip including at least one magneto-electronic-resonance sensor. When the test strip is within the opening, the interrogation coil may utilize magneto-electronic-resonance technology to interrogate the magneto-electronic-resonance sensor and the pick-up coil may be used to sense a resultant oscillation frequency of the magneto-electronic-resonance sensor, the resultant oscillation frequency associated with the characteristic. The test strip may include a plurality of sensors. The sensors may be coated with a coating sensitive to a characteristic of the fluid, where the interrogation reveals information about the fluid characteristic. | 2011-12-22 |
20110312005 | Enzymatic modification of cell-surface H antigen by glycosyltransferases - This invention relates to cells with modified blood group antigen expression. In particular, the invention relates to cells for use in haematology, immunohaemotology and immunology assays as serology controls. | 2011-12-22 |
20110312006 | Enzymatic Assay for the Quantitative Determination of Phospholipase A1 or A2 Activity in a Sample - The invention relates to a new method for measuring a calcium-dependent phospholipase A1 or A2 enzymatic activity in a sample, comprising the following steps: a) contacting said sample with a solid phase coated with a fluorochrome-labelled phospholipase A1 or A2 substrate, wherein the molecular coverage is in the range 8 to 30 fluorochrome-labelled phospholipase A1 or A2 substrate molecules/nm2 in conditions where calcium-dependent phospholipase A1 or A2 enzymatic activity is blocked. b) reading the fluorescence emission overtime c) adding a solution to initiate calcium-dependent phospholipase A1 or A2 enzymatic activity d) reading the fluorescence emission overtime, and kits for carrying out said method. | 2011-12-22 |
20110312007 | Detection of Histone Deacetylase Inhibition - Provided are compositions and methods for intracellular detection of enzyme activity. One example of a composition is a histone deacetylase substrate comprising a compound of the following formula (I): | 2011-12-22 |
20110312008 | Enzymatic Assay for the Quantitative Determination of Phospholipase A1 or A2 Activity in a Sample - The invention relates to a new method for measuring phospholipase A1 or A2 activity in a sample, using a solid phase coated with a fluorochrome-labelled phospholipase A1 or A2 substrate, wherein the molecular coverage is in the range from 8 to 30 fluorochrome-labelled phospholipase A1 or A2 substrate molecules/nm2, and kit for carrying out said method. | 2011-12-22 |
20110312009 | COMPOSITION FOR ASSAYING GLYCATED PROTEINS - Compositions for accurately assaying a glycated protein by: 1) avoiding effects of globulin and ascorbic acid components, 2) stabilizing proteases and at least enzymes acting on glycated amino acids; 3) accurately assaying albumin; and 4) assaying glycated albumin while avoiding the effects of glycated hemoglobin, and an assay method are provided. Thus, the contents of a glycated protein and glycated albumin can be more accurately determined. | 2011-12-22 |
20110312010 | COMPARISON OF PROTEIN SAMPLES - Methods of qualitatively and/or quantitatively detecting the presence of mutations, modifications or impurities in a protein sample are provided. The methods utilize isotopically labeled variants of amino acids incorporated into proteins prior to protein digest to enable comparisons of two protein samples in bottom-up liquid chromatography. | 2011-12-22 |
20110312011 | DIAGNOSTIC DEVICES AND METHODS OF USE - The present invention relates to methods of diagnosing samples as well as various microfluidic, microcentrifuge and microfilter devices. In one embodiment, the present invention provides a method of diagnosing neurodegenerative diseases using mitochondrial and/or platelet samples. In another embodiment, the present invention provides a microfluidic device that selectively captures and analyzes a desired amount of target biological particle. | 2011-12-22 |
20110312012 | METHOD AND KIT FOR ASSESSING VIABLE CELLS - The present invention provides simple, rapid methods and procedures for analyzing cells, hereunder quantitative and qualitative assessment of cells, such as viability. The present invention relates to the use of various optionally substituted reporter compounds particularly detectable upon their reaction with thiol-containing species present in higher concentrations in intact (e.g., living) cells than in non-intact (e.g., dead, stressed and apoptotic) cells. The present invention also relates to the use of various optionally substituted reporter compounds particularly detectable upon their reaction with species present in intact and/or non-intact cells. Moreover, the present invention relates to the use of measuring techniques and/or instruments coupled with the use of various optionally substituted reporter compounds. The invention further relates to compositions used in methods for analyzing cells, such as a composition comprising N-(7-dimethylamino-4-methyl-3-coumarinyl)-maleimide (DACM). | 2011-12-22 |
20110312013 | METHOD AND KIT FOR EXAMINATION OF CELLS USING N-(9-ACRIDINYL) MALEIMIDE (NAM) OR USING 7-DIETHYLAMINO-3-((4'-IODACETYL)AMINO)PHENYL)-4-METHYLKCOUMARIN (CPI) - The present invention provides simple, rapid methods and procedures for analyzing cells, hereunder quantitative and qualitative assessment of cells. The present invention relates to the use of N-(9-acridinyl)maleimide (NAM) or to the use of 7-diethylamino-3-((4′-(iodoacetyl)amino)phenyl)-4-methylcoumarin (CPI), particularly detectable upon its reaction with species (e.g., sulphur-containing species) present in higher concentrations in intact (e.g., living) cells than in non-intact (e.g., dead) cells. The present invention also relates to the use of NAM or to the use of 7-diethylamino-3-((4′-(iodoacetyl)amino)phenyl)-4-methylcoumarin (CPI), particularly detectable upon its reaction with species present in intact and/or non-intact cells. Moreover, the present invention relates to the use of measuring techniques and/or instruments coupled with the use of NAM or with the use of 7-diethylamino-3-((4′-(iodoacetyl)amino)phenyl)-4-methylcoumarin (CPI). The invention further relates to compositions used in methods for analyzing cells. | 2011-12-22 |
20110312014 | PROBE FOR DETECTION AND QUANTIFICATION OF NITRIC OXIDE, AND METHOD FOR DETECTING AND QUANTIFYING NITRIC OXIDE USING THE SAME | 2011-12-22 |
20110312015 | RAPID THROMBOCHEK TEST KIT BASED ON WHOLE BLOOD SCREENING TEST TO DETECT PLATELET HYPERAGGREGATION AT A TEMPERATURE OF 37 C IN THE CLINICAL LABORATORY - The new RAPID THROMBOCHEK TEST KIT is based on thrombochek screening test for measurement of hyperaggregable platelets in whole blood, which may be present either in form of circulating platelet aggregates, spontaneously aggregating platelets or reacting to weak agonist of platelet aggregation in low concentration—all together, in order to investigate thrombotic tendencies and to assess the efficacy of antithrombotic therapy all measured with help of hematology cell counter and magnetic stirrer at 37° C. of temperature. This is compared to the other existing microscopic method and shows 0.97% correlation. RAPID THROMBOCHEK TEST KIT based on the above methodology is to be used with the aid of an automated hematology analyser and is made available for routine clinical and office laboratory use. | 2011-12-22 |
20110312016 | Method for Evaluating Immunosuppression - Provided is a method for determining immunosuppression in an individual. The method entails obtaining a sample of blood from an individual, contacting cells in the blood sample with an activating agent to obtain activated cells, measuring the amount of nuclear NFkB in the activated cells, and comparing the amount of nuclear NFkB in the activated cells to a control. An amount of nuclear NFkB that is higher than the control is considered to be indicative of insufficient immunosuppression in the individual. An amount of nuclear NFkB that is lower than the control is considered to he indicative of excessive immunosuppression in the individual. An amount of nuclear NFkB that is the same as the control is considered to be indicative of an appropriate amount of immunosuppression in the individual. | 2011-12-22 |
20110312017 | DIAGNOSIS OF ENTRY OF GASTROINTESTINAL CONTENTS INTO RESPIRATORY TRACT OF HUMANS AND ANIMALS - A method of diagnosing respiratory fluid in a patient suffering from gastro esophageal reflux disease (GERD) is disclosed. The method comprises (1) orally administering to a subject suspected of suffering from gastro esophageal reflux disease (GERD), a formulation comprised of a plurality of particles comprised of a biocompatible polymer (e.g. carnauba wax) and a detectable, non-radioactive label (e.g. a fluorescent label), (2) allowing the formulation to remain in the subject over a period of time during which the subject would be expected to aspirate the formulation, (3) collecting respiratory fluid from the subject, and (4) analyzing the respiratory fluid to determine if the fluid contains the detectable label, and thereby determining if the subject regurgitates fluid into the respiratory tract. Alternatively, or additionally, a subject swallows a label that is not destroyed in the respiratory tract, or in the gastrointestinal tract, which further has the property that it is absorbed from the respiratory tract but not from the gastrointestinal tract. The presence of the label is then analyzed in blood, or, if the substance is excreted from blood to urine, in urine samples. The qualitative analysis can be also expanded into quantitative analysis, enabling the estimation of either the concentration, or the amount, or both, of the gastrointestinal contents that entered the respiratory tract. | 2011-12-22 |
20110312018 | Blood-Brain Barrier Model - A method of creating a multicellular blood-brain barrier model is disclosed. In one embodiment, the method comprises culturing primary brain microvascular endothelial cells or embryonic stem cell-derived endothelial cells upon a permeable support in the presence of neural progenitor cells. | 2011-12-22 |
20110312019 | Predicting Human Developmental Toxicity of Pharmaceuticals Using Human Stem-Like Cells and Metabolomics - The invention provides biomarker profiles of metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals using human stem-like cells (hSLCs) or lineage-specific cells produced therefrom. The inventive methods are useful for testing toxicity, particularly developmental toxicity and detecting teratogenic effects of such chemical compounds. Specifically, a more predictive developmental toxicity model, based on an in vitro method that utilizes both hSLCs and metabolomics to discover biomarkers of developmental toxicity is disclosed. | 2011-12-22 |
20110312020 | Ex-Vivo Passive Protection Bacteremia Assay - The present disclosure provides methods for assessing bactericidal antibodies in a biological sample by use of human fresh whole blood from a non-immune human as a reaction medium for the assay. | 2011-12-22 |
20110312021 | METHOD AND APPARATUS FOR THE NON-INVASIVE MONITORING OF GAS EXCHANGE BY BIOLOGICAL MATERIAL - The invention provides an indirect pressure sensing system for non-invasive measurement of primary pressure in a sealed container, which communicates primary pressure changes from within the container, via a flexible diaphragm, to a secondary chamber wherein there is a defined relationship between the primary and secondary pressures, which enables a pressure sensor in the secondary chamber to generate a signal representing primary pressure in the sealed container, but to remain isolated from the contents of the sealed container. The pressure sensor can provide electrical outputs representing the pressure detected, and the outputs are fed to data processing means capable of producing a measurement of primary pressure. The system can have a liquid culture of cellular material (eg. micro organisms, plant tissue cells, animal cells etc) partially filling the container, whereby the metabolism and/or growth of cellular material causes gas exchanges between liquid and headspace, which can result in primary pressure changes. | 2011-12-22 |
20110312022 | METHOD FOR DETERMINING PERCENT HYBRIDITY IN MODIFIED HYBRID CROPS - Methods of introducing sentinel traits into foundation seed are described. The frequency of occurrence of the sentinel trait in the hybrid seed product relative to the frequency of the sentinel trait in a pollinator seed product are used to determine the percentage of hybridity in modified hybrid varieties. | 2011-12-22 |
20110312023 | Integrated Technology of Algae Bio-Diesel and Algae Ferment Reuse - An integrated technology of algae bio-diesel and algae ferment reuse includes providing algae, placing the algae into an optical reactor to grow the algae into rich algae, abstracting the rich algae to form abstracted algae and fat, placing the abstracted algae into a ferment tank so that the abstracted algae are decomposed and fermented to form a fermented substance and a fermented liquid, and making the fermented substance and the fermented liquid into a by-product. Thus, the algae produce carbon dioxide during the fermenting process, so that the carbon dioxide produced by the abstracted algae in the ferment tank is supplied to the algae in the optical reactor to form a breathing cycle between the optical reactor and the ferment tank so as to promote the growth of the algae simultaneously. | 2011-12-22 |
20110312024 | METHOD OF AND APPARATUS FOR FERMENTING BIOMASS - The invention relates to a method of and an apparatus for fermenting organic material in an apparatus comprising a container. The method includes the steps of feeding organic material and fermenting microbes ( | 2011-12-22 |
20110312025 | IMPROVED PRODUCTION OF RIBOFLAVIN - The present invention provides an improved biotechnological production of riboflavin (also referred herein as vitamin B2) through modification in the operon containing the riboflavin biosynthetic genes (rib operon), in particular modifications of/in the leader sequences (rib leader) upstream of the corresponding riboflavin biosynthetic genes (rib operon). Furthermore, the present invention relates to genetically engineered microorganisms carrying said modified sequences, processes to generate said modified sequences/microorganisms and the use thereof for production of riboflavin. | 2011-12-22 |
20110312026 | PROCESS FOR THE PRODUCTION OF RIBOFLAVIN - The invention relates to processes and means for the biotechnologically fermentative production of riboflavin (hereinafter also referred to as vitamin B2) and means for the implementation of this process, in particular a modified microbial host cell with increased riboflavin yield. The invention thus provides new processes and means for the regulation of the expression of enzyme activities involved in the riboflavin production of the host cell. | 2011-12-22 |
20110312027 | Production of Carrier-Peptide Conjugates Using Chemically Reactive Unnatural Amino Acids - Provided are methods of making carrier polypeptide that include incorporating a first unnatural amino acid into a carrier polypeptide variant, incorporating a second unnatural amino acid into a target polypeptide variant, and reacting the first and second unnatural amino acids to produce the conjugate. Conjugates produced using the provided methods are also provided. In addition, orthogonal translation systems in methylotrophic yeast and methods of using these systems to produce carrier and target polypeptide variants comprising unnatural amino acids are provided. | 2011-12-22 |
20110312028 | Novel Lipolytic Enzyme ELIP - The present invention provides a novel nucleic acid sequence, designated ELIP, encoding a lipolytic enzyme and the corresponding encoded amino acid sequences. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding at least one novel lipolytic enzyme, recombinant lipolytic enzyme proteins and methods for producing the same. | 2011-12-22 |
20110312029 | NOVEL REGULATORY ELEMENTS - The invention concerns novel regulatory elements as well as related vectors and cells. Furthermore, it relates to methods of improving expression of polypeptides from nucleic acids such as cloned genes and to the production of various polypeptides in host cells using said novel regulatory elements. Additionally, the invention relates to uses of said novel regulatory elements as insulators, in gene therapy or for improving host cell lines. | 2011-12-22 |
20110312030 | CONSISTENT HIGH EXPRESSION VECTOR CONTAINING REP E MUTATED GENE - A vector for constitutively expressing a high level of a target protein, and more particularly a RepE mutant protein containing a deletion of 21 amino acids in the C-terminal region of a RepE protein and a vector for constitutively expressing a high level of a target protein, which comprises a gene encoding the mutant protein. The constitutive high-level expression vector can stably express a high level of a target protein. Also, the surface expression vector can express a target protein on the surface of recombinant microorganisms while constitutively expressing a high level of the target protein, and thus will be useful for construction of an antigen for vaccines. | 2011-12-22 |
20110312031 | TRICHODERMA PROMOTER - A promoter for use in producing proteins in filamentous fungal host cells is provided. In one embodiment, the promoter comprises SEQ ID NO:1, or a variant or a truncated form thereof that has promoter activity in a host cell. Also provided are recombinant nucleic acids, vectors containing the promoter and host cells containing a recombinant nucleic acid or vector. Methods of producing a protein using the host cells are also provided. | 2011-12-22 |
20110312032 | VECTORS AND YEAST STRAINS FOR PROTEIN PRODUCTION - Lower eukaryote host cells in which the function of at least one endogenous gene encoding a chaperone protein, such as a Protein Disulphide Isomerase (PDI), has been reduced or eliminated and at least one mammalian homolog of the chaperone protein is expressed are described. In particular aspects, the host cells further include a deletion or disruption of one or more O-protein mannosyltransferase genes, and/or overexpression of an endogenous or exogenous Ca2 | 2011-12-22 |
20110312033 | METHODS OF SPRAYING SACCHARIFICATION ENZYMES AND FERMENTATION ORGANISMS ONTO LIGNOCELLULOSIC BIOMASS FOR HYDROLYSIS AND FERMENTATION PROCESSES - The present invention provides spray methods of delivering saccharification enzymes, fermentation organisms, and other hydrolysis or fermentation ingredients onto lignocellulosic biomass. The methods reduce the need for mechanical mixing when the biomass solids are undergoing enzymatic hydrolysis, and reduce dilution to allow higher product titers in the hydrolysis and/or fermentation steps. | 2011-12-22 |
20110312034 | Recombined Molecules and Preparation Thereof - The invention relates to novel molecules and libraries thereof as well as methods for their production. Methods of producing the novel molecules include the cleaving of starting molecules into molecular subunits and the assembly of the subunits into novel recombined molecules. | 2011-12-22 |
20110312035 | STABILIZED COMPOSITIONS OF THERMOSTABLE DNA POLYMERASE AND ANIONIC OR ZWITTERIONIC DETERGENT - The present invention provides compositions, methods, and kits for protecting thermostable DNA polymerase during amplification reactions conducted at a temperature ranging from about 40° C. to greater than 100° C. The composition comprises a thermostable DNA polymerase and an anionic detergent or zwitterionic detergent. | 2011-12-22 |
20110312036 | MICROCHIP FOR ISOTHERMAL NUCLEIC-ACID AMPLIFICATION REACTION, METHOD FOR PRODUCING THE SAME, AND ISOTHERMAL NUCLEIC-ACID AMPLIFICATION METHOD - A microchip for an isothermal nucleic-acid amplification reaction in which at least one of substances necessary for an isothermal amplification reaction of a nucleic acid is present in a reaction region functioning as a reaction field of the reaction, the at least one of the substances being covered with a thin film that melts at a temperature higher than room temperature and lower than a reaction temperature of the reaction. | 2011-12-22 |
20110312037 | DNA POLYMERASES WITH INCREASED 3'-MISMATCH DISCRIMINATION - Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases. | 2011-12-22 |
20110312038 | DNA POLYMERASES WITH INCREASED 3'-MISMATCH DISCRIMINATION - Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases. | 2011-12-22 |
20110312039 | DNA POLYMERASES WITH INCREASED 3'-MISMATCH DISCRIMINATION - Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases. | 2011-12-22 |
20110312040 | Preferential Amplification of mRNA Over DNA Using Chemically Modified Primers - The present invention relates to a method, oligonucleotides, reaction mixtures and kits for the selective amplification of a messenger RNA target comprising an exon-exon junction, using an oligonucleotide that comprises at least one nucleotide modified at the exocyclic amino group. | 2011-12-22 |
20110312041 | DNA POLYMERASES WITH INCREASED 3'-MISMATCH DISCRIMINATION - Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases. | 2011-12-22 |
20110312042 | METHOD FOR PRODUCING AMINO ACID - According to the present invention, a process for producing an amino acid using a microorganism in which aspartate aminotransferase activity is decreased or deleted, and which has the capability of producing and accumulating the amino acid is provided. | 2011-12-22 |
20110312043 | EXTRACTION SOLVENTS DERIVED FROM OIL FOR ALCOHOL REMOVAL IN EXTRACTIVE FERMENTATION - In an alcohol fermentation process, oil derived from biomass is hydrolyzed into an extractant available for in situ removal of a product alcohol such as butanol from a fermentation broth. The glycerides in the oil can be catalytically (e.g., enzymatically) hydrolyzed into free fatty acids, which form a fermentation product extractant having a partition coefficient for a product alcohol greater than a partition coefficient of the oil of the biomass for the product alcohol. Oil derived from a feedstock of an alcohol fermentation process can be hydrolyzed by contacting the feedstock including the oil with one or more enzymes whereby at least a portion of the oil is hydrolyzed into free fatty acids forming a fermentation product extractant, or the oil can be separated from the feedstock prior to the feedstock being fed to a fermentation vessel, and the separated oil can be contacted with the enzymes to form the fermentation product extractant. The fermentation product extractant can be contacted with a fermentation broth for in situ removal of a product alcohol. | 2011-12-22 |
20110312044 | EXTRACTION SOLVENTS DERIVED FROM OIL FOR ALCOHOL REMOVAL IN EXTRACTIVE FERMENTATION - In an alcohol fermentation process, oil derived from biomass is chemically converted into an extractant available for in situ removal of a product alcohol such as butanol from a fermentation broth. The glycerides in the oil can be chemically converted into a reaction product, such as fatty acids, fatty alcohols, fatty amides, fatty acid methyl esters, fatty acid glycol esters, and hydroxylated triglycerides, and mixtures thereof, which forms a fermentation product extractant having a partition coefficient for a product alcohol greater than a partition coefficient of the oil of the biomass for the product alcohol. Oil derived from a feedstock of an alcohol fermentation process can be chemically converting into the fermentation product extractant. The oil can be separated from the feedstock prior to the feedstock being fed to a fermentation vessel, and the separated oil can be chemically converted to a fermentation product extractant, which can then contacted with a fermentation product comprising a product alcohol, whereby the product alcohol is separated from the fermentation product. | 2011-12-22 |
20110312045 | FERMENTATION PROCESSES - The present invention provides a method for the production of at least one of a fermentation product and a derivate thereof comprising the steps of: a. providing a fermentable aqueous solution comprising at least one fermentable compound and at least one impurity; b. selectively extracting the at least one impurity from at least a portion of the fermentable aqueous solution by means of an extractant to form an impurity-depleted fermentable solution comprising a fermentable compound and to form an impurity-comprising extract; and c. fermenting the fermentable compound of the impurity-depleted fermentable solution to form a fermentation broth comprising a fermentation product wherein the extractant comprises at least one of the fermentation product and a derivate thereof. | 2011-12-22 |
20110312046 | Methods for C4 Dicarboxylic Acid Production in Filamentous Fungi - The present invention relates to methods of producing C4-dicarboxylic acids, such as malic acid, comprising: (a) cultivating a host cell comprising a polynucleotide encoding a C4-dicarboxylic acid transporter; and (b) recovering the C4-dicarboxylic acid. The present invention also relates to methods for increasing C4-dicarboxylic acid production, as well as host cells comprising the polynucleotides. | 2011-12-22 |
20110312047 | Polypeptides having C4 Dicarboxylic Acid Transporter Activity and Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having C4-dicarboxylic acid transporter activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, and methods of producing C4-dicarboxylic acids, such as malic acid. | 2011-12-22 |
20110312048 | CONVERSION METHOD - A process is described for the preparation of water-soluble cellulose hydrolysis products The process comprises admixing cellulose with an ionic liquid capable of solvating or dissolving at least some of the cellulose, said ionic liquid being a compound comprised solely of cations and anions and which exists in a liquid state at a temperature at or below 15O° C., and in which the anions are selected from sulfate, hydrogen sulfate and nitrate; and treating the resulting solvate or solution with an acid in the presence of water, said acid having a pKa in water of less than 2 at 25° C. | 2011-12-22 |
20110312049 | MICROORGANISMS AND METHODS FOR THE PRODUCTION OF ETHYLENE GLYCOL - The invention provides non-naturally occurring microbial organisms having an ethylene glycol pathway. The invention additionally provides methods of using such organisms to produce ethylene glycol. | 2011-12-22 |
20110312050 | CONTINUOUS CATALYTIC GENERATION OF POLYOLS FROM CELLULOSE - A catalytic process for generating at least one polyol from a feedstock comprising cellulose is performed in a continuous manner using a catalyst comprising nickel tungsten carbide. The process involves, contacting, continuously, hydrogen, water, and a feedstock comprising cellulose, with the catalyst to generate an effluent stream comprising at least one polyol and recovering the polyol from the effluent stream. | 2011-12-22 |
20110312051 | PROCESS FOR GENERATION OF POLYOLS FROM SACCHARIDE CONTAINING FEEDSTOCK - A process for generating at least one polyol from a feedstock comprising saccharide is performed in a continuous or batch manner. The process involves, contacting hydrogen, water, and a feedstock comprising saccharide, with a catalyst system to generate an effluent stream comprising at least one polyol and recovering the polyol from the effluent stream. The catalyst system comprises at least one metal component with an oxidation state greater than or equal to 2+. | 2011-12-22 |
20110312052 | PROCESS FOR CELL-FREE PRODUCTION OF CHEMICALS - An enzymatic process is described for the production of chemicals from carbon sources. In particular, according to one aspect, a process for the production of a target organic compound from a carbon source by a cell-free enzyme system is disclosed. | 2011-12-22 |
20110312053 | SUPPLEMENTATION OF FATTY ACIDS FOR IMPROVING ALCOHOL PRODUCTIVITY - Fatty acids derived from biomass at a step in a fermentation process can be added to a fermentation medium comprising a recombinant microorganism that produces a product alcohol. At least one of growth rate and fermentable carbon consumption of the microorganism is greater in the presence of the fatty acids than the growth rate and the fermentable carbon consumption of the microorganism in the absence of the fatty acids. The addition of the fatty acids can increase glucose consumption, and can improve microorganism biomass production (cell growth/density) and growth rate, thereby reducing production time and increasing productivity of the fermentation process. | 2011-12-22 |
20110312054 | Isolation and Characterization of Schizochytrium Aggregatum Cellobiohydrolase I (CBH I) - The present invention provides for the isolation and characterization of the cbh1 gene from | 2011-12-22 |
20110312055 | METHOD OF PRODUCTION OF ALCOHOL - The invention provides a process for producing alcohol from a cellulosic material, said process comprising: hydrolyzing said cellulosic material with an aqueous acid to produce a hydrolysate; extracting acid and water from said hydrolysate with a water-miscible organic extraction solvent to yield (a) a first aqueous acidic solution containing said extraction solvent and (b) a residue containing sugars; subjecting said residue to an oligosaccharide cleavage reaction to yield an aqueous solution of fermentable sugars; fermenting said fermentable sugars and distilling alcohol from the resulting fermented mixture; contacting said first aqueous acidic solution with a pressurized fluid lipophilic solvent in non-gaseous form, which fluid solvent is substantially water-immiscible and is gaseous at ambient conditions, to yield a second aqueous acid solution and a solvent mixture of said extraction solvent and said fluid solvent; depressurizing said solvent mixture to release said extraction solvent for recycling; and, optionally, concentrating said second aqueous acid solution for recycling. | 2011-12-22 |
20110312056 | Plasma Membrane Isolation - The present invention relates to a population of monodisperse magnetic nanoparticles with a diameter between 1 and 100 nm which are coated with a layer with hydrophilic end groups. Herein the layer with hydrophilic end groups comprises an inner layer of monosaturated and/or monounsaturated fatty acids bound to said nanoparticles and bound to said fatty acids, an outer layer of a phospholipid conjugated to a monomethoxy polyethyleneglycol (PEG) comprising a hydrophilic end group, | 2011-12-22 |
20110312057 | LIPASE-CONTAINING POLYMERIC COATINGS FOR THE FACILITATED REMOVAL OF FINGERPRINTS - A substrate or coating is provided that includes a lipase with enzymatic activity toward a component of a fingerprint. Also provided is a process for facilitating the removal of fingerprints is provided wherein an inventive substrate or coating including a lipase is capable of enzymatically degrading of one or more components of the fingerprint to facilitate fingerprint removal from the substrate or said coating. Applying heat to the substrate or coating increases the rate of fingerprint removal. | 2011-12-22 |
20110312058 | POLYPEPTIDES WITH XYLANASE ACTIVITY, - Polypeptides with xylanase activity modified to increase bran solubilisation and/or xylanase activity. The modification comprises at least an amino acid modification i position 110 and may have further modifications of one or more amino acids in position 11, 12, 13, 34, 54, 77, 81, 99, 104, 113, 114, 118, 122, 141, 154, 159, 162, 164, 166 or 175 wherein the positions are determined as the position corresponding the position of | 2011-12-22 |
20110312059 | TAU PROTEASE COMPOSITIONS AND METHODS - Tau protein has a causative role in Alzheimer's disease and multiple other neurodegenerative disorders exhibiting tau histopathology collectively termed tauopathies. The primary function of tau protein is to facilitate assembly and maintenance of microtubules in neuronal axons. In the disease process tau protein becomes modified, loses its affinity to microtubules and accumulates in the cell body where it forms aggregates. The large neurofibrillary tangles formed from tau protein assembled into filaments were thought to be the pathological structure of tau. However, more recent work indicates that smaller, soluble oligomeric forms of tau are best associated with neuron loss and memory impairment. A novel and unexpected protease activity has been discovered to be associated with tau in oligomeric but not monomeric structures. Methods have been developed to form and purify tau protease and to assay its activity. Tau protease activity constitutes a totally novel mechanism for tau-mediated neurodegenerative disease by causing tau loss of function, as it cleaves itself, and gain of toxic function as it can cleave other proteins and facilitate cell death through apoptotic and/or senescence pathways. Tau protease presents a novel and unique target for the development of therapeutics that may be achieved by several strategies including by inhibiting the tau oligomer enzymatic activity. | 2011-12-22 |
20110312060 | PURIFICATION OF VACCINIA VIRUS- AND RECOMBINANT VACCINIA VIRUS-BASED VACCINES - The present invention relates to methods for purification of Vaccinia viruses (VV) and/or Vaccinia virus (VV) particles, which can lead to highly pure and stable virus preparations of predominantly biologically active viruses. The invention encompasses purifying a virus preparation in a sterilized way with high efficiency and desirable yield in terms of purity, biological activity and stability, aspects advantageous for industrial production. | 2011-12-22 |
20110312061 | NOVEL LACTOBACILLUS PLANTARUM AND COMPOSITION CONTAINING THE SAME - The present invention provides | 2011-12-22 |
20110312062 | PHOTOBIOREACTOR SYSTEM FOR MASS PRODUCTION OF MICROORGANISMS - A photobioreactor system for mass production of microorganisms is disclosed. Water with microorganisms suspended therein is sprayed through a nozzle to create droplets. These droplets have a high surface area to volume ratio enabling efficient light transfer and gas diffusion. The water may also be passed through channels between two transparent plates, wherein superior mixing is achieved along with a high surface to volume ratio. The water is preferably circulated through a dark holding tank Active and passive flashing lights of different wavelengths are used to promote growth of the microorganisms when the water is sprayed and/or passing through the transparent plates. | 2011-12-22 |
20110312063 | Method for Harvesting Algae - The present invention relates to a method for collecting algae from an algae containing aqueous solution. The method comprises first, providing an organic coagulant to said solution and mixing the formed solution. Subsequently, an inert inorganic clay material is provided with mixing to the solution for coagulating said algae. The resulting solution is agitated and the algae is separated and collected from the solution. | 2011-12-22 |
20110312064 | METHODS OF REMOVING OILY STAINS FROM FABRICS - Described are compositions and methods for removing oily stains from fabrics by treating the fabrics with cyclodextrins. Cyclodextrins can be added to the fabrics or generated in situ by converting a substrate of starch or dextrin with cyclomaltodextrin glucanotransferase. | 2011-12-22 |
20110312065 | CLEARCOAT CONTAINING THERMOASE C160 FOR EASY-CLEANING OF INSECT BODY STAINS - A substrate or coating is provided that includes a protease with enzymatic activity toward a component of a biological stain. Also provided is a process for facilitating the removal of a biological stain is provided wherein an inventive substrate or coating including a protease is capable of enzymatically degrading of one or more components of the biological stain to facilitate biological stain removal from the substrate or said coating. | 2011-12-22 |
20110312066 | ENZYMATIC PREPARATION OF PLANT FIBERS - A method of extracting fibers from decorticated plant bast skin involves pre-treating decorticated plant bast skin of a fiber plant with an aqueous solution containing trisodium citrate having a pH in a range of about 8-14 at a temperature of about 90° C. or less; and subsequently treating recovered fibers with a protease at alkaline pH. | 2011-12-22 |
20110312067 | DIALYSIS DEVICE FOR SEPARATING PATHOGENS FROM A BIOLOGICAL SAMPLE - A dialysis device to separate pathogens from a biological sample, the dialysis device having a first channel for receiving the biological sample, a second channel, and, a plurality of apertures, wherein, the second channel is fluidically connected to the first channel via the apertures such that the pathogens flow from the first channel to the second channel and larger constituents in the biological sample remain in the first channel. | 2011-12-22 |
20110312068 | DIALYSIS DEVICE FOR SEPARATING NUCLEATED CELLS IN A BIOLOGICAL SAMPLE FROM OTHER CONSTITUENTS - A dialysis device to separate nucleated cells in a biological sample from smaller constituents, the dialysis device having a first channel for receiving the biological sample, a second channel, and, a plurality of apertures, wherein, the second channel is fluidically connected to the first channel via the apertures, the apertures being smaller than the nucleated cells such that the smaller constituents flow from the first channel to the second channel and the nucleated cells in the biological sample remain in the first channel | 2011-12-22 |
20110312069 | MICROVIAL WITH DIGITAL MEMORY FOR STORAGE OF OLIGONUCLEOTIDE SPECIFICATION DATA - An oligonucleotide microvial for an oligonucleotide dispensing apparatus, the microvial having a container for holding a volume of reagent, an integrated circuit with digital memory storing oligonucleotide data relating to specifications characterizing the oligonucleotides, and, electrical contacts for connection to a control processor in the reagent dispensing apparatus to provide the data to the control processor for download into devices supplied with the oligonucleotides. | 2011-12-22 |
20110312070 | MICROFLUIDIC DEVICE WITH PCR CHAMBER FOR HIGH RATE OF TEMPERATURE CHANGE - A microfluidic device having a supporting substrate, a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having a PCR chamber, and, a heater element for heating the nucleic acid sequences within the PCR chamber, wherein during use, the heater element heats the nucleic acid sequences at a rate more than 80 K per second. | 2011-12-22 |
20110312071 | MICROFLUIDIC DEVICE WITH LARGE CHANNELS FOR CELL TRANSPORT AND SMALL CHANNELS SUITABLE FOR BIOCHEMICAL PROCESSES - A microfluidic device for molecular diagnostic analysis of a biological sample containing cells, the microfluidic device having a supporting substrate, a plurality of microsystems technology (MST) channels each with a cross-sectional area between 1 square micron and 400 square microns for biochemical processing of constituents within the biological sample, and, a plurality of cell transport channels, each with a cross-sectional area greater than 400 square microns for receiving the biological sample and transporting cells within the biological sample to predetermined sites in the MST channels. | 2011-12-22 |
20110312072 | MICROFLUIDIC DEVICE WITH SURFACE MICRO-MACHINED CHIPS AND INTERCONNECTING CAP - A microfluidic device for diagnostic analysis of a sample fluid, the microfluidic device having a plurality of lab-on-a-chip (LOC) devices each having a supporting substrate and a microsystems technology (MST) layer for processing the sample fluid, and, a cap interconnecting the plurality of LOC devices, the cap having a cap channel for establishing fluid communication between the MST layers on at least two of the LOC devices. | 2011-12-22 |
20110312073 | MICROFLUIDIC TEST MODULE INCORPORATING SURFACE MICRO-MACHINED CHIPS AND INTERCONNECTING CAP - A test module having a casing for hand held portability, a receptacle for receiving a sample fluid, and, a microfluidic device in fluid communication with the inlet, the microfluidic device having a plurality of lab-on-a-chip (LOC) devices and a cap in engagement with each of the plurality of LOC devices, wherein, the cap is configured to establish fluid communication between at least two of the LOC devices. | 2011-12-22 |
20110312074 | MICROFLUIDIC TEST MODULE WITH SAMPLE RECEPTACLE - A test module having a receptacle for receiving an unprocessed biological sample through an opening, a cover movable between open and closed positions, the cover exposing the opening when in the open position and closing the opening when in the closed position, and, a microfluidic device for processing the biological sample, the microfluidic device having a sample inlet, wherein, the receptacle is configured for fluid communication with the sample inlet such that the biological sample flows to the sample inlet by capillary action. | 2011-12-22 |
20110312075 | LOC DEVICE WITH PARALLEL INCUBATION AND PARALLEL DNA AND RNA AMPLIFICATION FUNCTIONALITY - A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample containing genetic material including DNA and RNA, a supporting substrate, a plurality of reagent reservoirs, a first incubation section, the first incubation section being in fluid communication with one of the reagent reservoirs containing enzymes for enzymatic reaction with the genetic material, a second incubation section, the second incubation section being in fluid communication with one of the reagent reservoirs containing enzymes for enzymatic reaction with the genetic material in parallel with the first incubation section, a first nucleic acid amplification section downstream of the first incubation section for amplifying at least some of the genetic material, and, a second nucleic acid amplification section downstream of the second incubation section for amplifying at least some of the genetic material in parallel with the first nucleic acid amplification section, wherein, the first incubation section, the second incubation section, the first nucleic acid amplification section and the second nucleic acid amplification section are all supported on the supporting substrate. | 2011-12-22 |
20110312076 | MICROFLUIDIC TEST MODULE WITH FLEXIBLE MEMBRANE FOR INTERNAL MICROENVIRONMENT PRESSURE-RELIEF - A microfluidic test module having an outer casing for hand held portability, and, a microfluidic device mounted within the outer casing for processing a biological sample, the outer casing providing a microenvironment adjacent the microfluidic device, wherein, the outer casing has a membrane seal of flexible material between the microenvironment and atmosphere for reducing pressure changes in the microenvironment resulting from atmospheric pressure fluctuations. | 2011-12-22 |
20110312077 | LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET NUCLEIC ACID SEQUENCES IN A FLUID WITH CALIBRATION CHAMBER CONTAINING PROBES DESIGNED TO BE NON-COMPLEMENTARY WITH ANY NUCLEIC ACID SEQUENCES IN THE FLUID - A lab-on-a-chip (LOC) device for detecting target nucleic acid sequences in a fluid, the LOC device having hybridization chambers containing electrochemiluminescent (ECL) probes for detecting the target nucleic acid sequences, each of the probes having an ECL luminophore for emitting photons when in an excited state, a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, at least one calibration chamber containing ECL probes designed to be non-complementary to any nucleic acid sequence in the fluid, and, electrodes for receiving an electrical pulse to excite the ECL luminophores. | 2011-12-22 |
20110312078 | MICROFLUIDIC DEVICE FOR DETECTING TARGET NUCLEIC ACID SEQUENCES IN MITOCHONDRIAL DNA - A microfluidic device for detecting mitochondrial DNA in a sample, the microfluidic device having an inlet for receiving a sample of biological material having cells with mitochondria containing mitochondrial DNA, a lysis section for lysing the mitochondria to release the mitochondrial DNA, probes for hybridization with target nucleic acid sequences in the mitochondrial DNA to form probe-target hybrids, and, a photosensor for detecting the probe-target hybrids. | 2011-12-22 |
20110312079 | LOC WITH DIGITAL MEMORY TO STORE EPIDEMIOLOGICAL UPDATES - A lab-on-a-chip (LOC) device for analyzing a sample fluid, the LOC device having a sample inlet for receiving the sample, a microsystems technology (MST) layer with functional sections for processing and analyzing the sample, and, CMOS circuitry with digital memory for storing epidemiological data, and configured to download epidemiological data updates from an external source. | 2011-12-22 |
20110312080 | POROUS FILMS BY A TEMPLATING CO-ASSEMBLY PROCESS - A method of making a composite includes providing a particle suspension comprising colloidal particles ( | 2011-12-22 |
20110312081 | REAGENT DISPENSING APPARATUS FOR ARRAY OF MICROFLUIDIC DEVICES - A reagent dispensing apparatus for loading reagents into a fixed array of microfluidic devices, each microfluidic device having a digital memory for data related to the reagents loaded into the microfluidic device, the reagent dispensing apparatus having a plurality of reagent vials each of the vials having an integrated circuit with memory storing data regarding the reagent in the vial, and a droplet dispenser, a mounting surface for detachably mounting the fixed array of microfluidic devices for movement relative to the vials, and, a control processor for operative control of the vials and the mounting surface, wherein, the control processor is configured to activate the droplet dispenser of the vial selected, move the vial into registration within one or more of the microfluidic devices within the fixed array and download the data from the integrated circuit to the digital memory of the one or more microfluidic devices. | 2011-12-22 |
20110312082 | DISPENSING APPARATUS FOR WAFER-SCALE DISPENSING OF REAGENTS - A reagent dispensing apparatus for loading reagents into a silicon wafer on which an array of lab-on-a-chip (LOC) devices are fabricated, each LOC device having a digital memory for data related to the reagents loaded into the LOC device, the reagent dispensing apparatus having a plurality of reagent vials each of the vials having an integrated circuit with memory storing data regarding the reagent in the vial, and a droplet dispenser, a mounting surface for detachably mounting the silicon wafer for movement relative to the vials, and, a control processor for operative control of the vials and the mounting surface, wherein, the control processor is configured to activate the droplet dispenser of the vial selected, move the vial into registration within one or more of the LOC devices on the silicon wafer and download the data from the integrated circuit to the digital memory of the one or more LOC devices. | 2011-12-22 |
20110312083 | COMPOSTER FOR A GARDEN - A composter having a downwardly open container ( | 2011-12-22 |
20110312084 | USE OF A TRANSPARENT COMPOSITION FOR PHOTOBIOREACTORS - The present invention relates to photobioreactors and more particularly to the use of a transparent composition based on at least one methacrylic polymer for constructing installations for the culture of photosensitive organisms. This composition can be in the form of films, plates, profiled elements or cylinders such as tubes. | 2011-12-22 |
20110312085 | IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING APPARATUS AND METHOD - An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. Each treatment step occurs within the same reaction compartment. The reaction conditions of each reaction compartment for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide. The reagents are preferably held in a reagent dispensing strip similar to a “blister pack”. | 2011-12-22 |
20110312086 | MODULATION OF EXON RECOGNITION IN PRE-MRNA BY INTERFERING WITH THE SECONDARY RNA STRUCTURE - The invention provides a method for generating an oligonucleotide with which an exon may be skipped in a pre-mRNA and thus excluded from a produced mRNA thereof. Further provided are methods for altering the secondary structure of an mRNA to interfere with splicing processes and uses of the oligonucleotides and methods in the treatment of disease. Further provided are pharmaceutical compositions and methods and means for inducing skipping of several exons in a pre-mRNA. | 2011-12-22 |
20110312087 | BIOREACTOR FOR THE CULTIVATION OF MAMMALIAN CELLS - Large-scale bioreactors having at least two impellers, large-scale bioreactor systems and methods for the large-scale cultivation and propagation of mammalian cells using these bioreactors. | 2011-12-22 |
20110312088 | CD19 BINDING AGENTS AND USES THEREOF - This invention, inter alia, relates to CD19 binding agents and methods of using such CD19 binding agents for treating disease. | 2011-12-22 |
20110312089 | PROCESS FOR CULTIVATING CELLS - A process for cultivation of differentiated human cells retaining stem cell potential is provided. The process comprises culturing differentiated human cells retaining stem cell potential anchored to a microcarrier selected from the group consisting of gelatin microcarriers and quaternary ammonium derivatised polystyrene microcarriers. | 2011-12-22 |
20110312090 | CARDIOMYOCYTE MEDIUM WITH DIALYZED SERUM - Methods and composition for maintenance of cardiomyocytes are provided. For example, in certain aspects methods including culturing the cardiomyocytes in a medium essentially free of serum or containing dialyzed serum to maintain long-term purity. In further aspects, methods for modulation of cardiomyocytes may be provided. | 2011-12-22 |
20110312091 | PLURIPOTENT STEM CELLS, METHOD FOR PREPARATION THEREOF AND USES THEREOF - Human pluripotent stem cells which are isolated from cut human umbilical cord or placenta and characteristic of cell surface marker CD151 | 2011-12-22 |
20110312092 | DUAL-TERMINAL AMIDE HYDROGELLING AGENT - Disclosed is a benzamide derivative represented by formula (1). In the formula, k1 represents an integer from 0-4, m1 represents an integer from 1-100, and n1 represents an integer from 1-6. In addition, R | 2011-12-22 |
20110312093 | COMPOSITIONS AND METHODS FOR PREVENTION AND TREATMENT OF AMYLOID-BETA PEPTIDE-RELATED DISORDERS - The present invention provides methods and compositions for modulating levels of amyloid-β peptide (Aβ) exhibited by cells or tissues. The invention also provides pharmaceutical compositions and methods of screening for compounds that modulate Aβ levels. The invention also provides modulation of Aβ levels via selective modulation (e.g., inhibition) of ATP-dependent γ-secretase activity. The invention also provides methods of preventing, treating or ameliorating the symptoms of a disorder, including but not limited to an Aβ-related disorder, by administering a modulator of γ-secretase, including, but not limited to, a selective inhibitor of ATP-dependent γ-secretase activity or an agent that decreases the formation of active (or optimally active) γ-secretase. The invention also provides the use of inhibitors of ATP-dependent γ-secretase activity to prevent, treat or ameliorate the symptoms of Alzheimer's disease. | 2011-12-22 |
20110312094 | USE OF DOUBLE STRANDED RNA TO INCREASE THE EFFICIENCY OF TARGETED GENE ALTERATION IN PLANT PROTOPLASTS - Method for targeted gene alteration in protoplasts of plant cells comprising the steps of transiently transfecting the protoplasts with a dsRNA that preferably targets plant MMR mRNA; and a mutagenic nucleobase. The transfection may be simultaneously or subsequently and the gene can be any gene functional in the mismatch repair system. | 2011-12-22 |
20110312095 | METHOD AND CONSTRUCTS FOR INCREASING RECOMBINANT PROTEIN PRODUCTION IN PLANTS DEHYDRATION STRESS - The present invention provides methods and constructs for increasing recombinant protein production in plants during dehydration stress. The invention includes nucleic acids, inducible expression systems, and methods for using same for increasing recombinant protein production in plants and plant protection. | 2011-12-22 |
20110312096 | CHEMICAL INDICATOR COMPOSITIONS, INDICATORS AND METHODS - Chemical indicator compositions comprising a bismuth compound; elemental sulfur; and a compound with relatively high water solubility which makes the composition alkaline when exposed to water vapor at an elevated temperature; a chemical indicator comprising a substrate and the composition coated on at least a portion of a major surface of the substrate; and methods of making and using the chemical indicator are disclosed. | 2011-12-22 |
20110312097 | GEL FOR RADIATION DOSIMETER AND RADIATION DOSIMETER WHICH USES THE SAME - Gel for radiation dosimeter including a gel part (A) and a gel part (B) that become cloudy when exposed to a fixed dose or more, wherein said gel part (A) exposed to more than a specified dose above the fixed dose maintains a cloudy state regardless of the decrease in external temperature; and said gel part (B) exposed to less than the specified dose above the fixed dose changes gradually from a cloudy state into a transparent state according to the decrease in external temperature. | 2011-12-22 |
20110312098 | SYSTEM AND METHOD OF ASSESSING NANOTUBE PURITY - The present invention is directed to methods for assessing the purity of carbon nanotube (CNT) compositions, specifically, a method for assessing the presence of contaminants in a CNT composition using polyaryl ethynyl (PAE) conjugate polymer as an indicator material. Additionally, compositions and kits comprising a polyaryl ethynyl (PAE) conjugate polymer are also provided. | 2011-12-22 |