51st week of 2014 patent applcation highlights part 44 |
Patent application number | Title | Published |
20140370542 | APPARATUS AND METHOD FOR DETECTING AND IDENTIFYING MICROORGANISMS - The present invention is an apparatus for detecting the presence, quantity and identity of one or more microorganisms in a sample and a method for using the same. The apparatus is composed of one or more chambers and a sensing element for sensing microorganisms. In particular embodiments, the sensing element is an array of chemoresponsive dyes deposited on a substrate in a predetermined pattern combination, wherein the combination of the dyes have a distinct and direct spectroscopic, transmission, or reflectance response to distinct analytes produced by the microorganism which is indicative of the presence, quantity and identity of the microorganism. | 2014-12-18 |
20140370543 | Expression Process - A process for the production of a target recombinant polypeptide is provided. The process comprises expressing an expression cassette encoding the target polypeptide and co-expressing an expression cassette encoding a mitochondrial foldase. Preferred mitochondrial foldases include Mia 40 and Erv1, and homologs thereof. | 2014-12-18 |
20140370544 | METHODS FOR IDENTIFYING SEQUENCE MOTIFS, AND APPLICATIONS THEREOF - The present invention relates to methods and algorithms that can be used to identify sequence motifs that are either under- or over-represented in a given nucleotide sequence as compared to the frequency of those sequences that would be expected to occur by chance, or that are either under- or over-represented as compared to the frequency of those sequences that occur in other nucleotide sequences, and to methods of scoring sequences based on the occurrence of these sequence motifs. Such sequence motifs may be biologically significant, for example they may constitute transcription factor binding sites, mRNA stability/instability signals, epigenetic signals, and the like. The methods of the invention can also be used, inter alia, to classify sequences or organisms in terms of their phylogenetic relationships, or to identify the likely host of a pathogenic organism. The methods of the present invention can also be used to optimize expression of proteins. | 2014-12-18 |
20140370545 | Reengineering mRNA Primary Structure for Enhanced Protein Production - Described herein are rules to modify natural mRNAs or to engineer synthetic mRNAs to increase their translation efficiencies. These rules describe modifications to mRNA coding and 3′ UTR sequences intended to enhance protein synthesis by: 1) decreasing ribosomal diversion via AUG or non-canonical initiation codons in coding sequences, and/or 2) by evading miRNA-mediated down-regulation by eliminating one or more miRNA binding sites in coding sequences. | 2014-12-18 |
20140370546 | Protease Deficient Filamentous Fungal Cells and Methods of Use Thereof - The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells. | 2014-12-18 |
20140370547 | EXPRESSION VECTOR ORGANIZATION, NOVEL PRODUCTION CELL GENERATION METHODS AND THEIR USE FOR THE RECOMBINANT PRODUCTION OF POLYPEPTIDES - Herein is reported an expression vector comprising—an antibody light chain expression cassette,—an antibody heavy chain expression cassette, and—a selection marker expression cassette, wherein the expression cassettes are arranged unidirectional, and wherein the expression cassettes are arranged in the 5′ to 3′ sequence of antibody heavy chain expression cassette, antibody light chain expression cassette and selection marker expression cassette. Further are reported herein methods for the generation of antibody producing cells and the use of these cells for the recombinant production of antibodies. | 2014-12-18 |
20140370548 | ANTIBODIES IMMUNOREACTIVE WITH HEREGULIN-COUPLED HER3 - Recombinant materials and methods for producing antibodies that specifically bind heregulin-coupled HER3, at a site distinct from the heregulin binding site, are described. These antibodies are particularly useful in treating cancer that expresses HER3. | 2014-12-18 |
20140370549 | Method for Producing Scyllo-Inositol - The disclosure provides a method of producing a scyllo-inositol or a new scyllo-inositol derivative in a one-step process, from ubiquitous and inexpensive raw materials. Also provided is a scyllo-inositol derivative bonded to saccharides such as glucose and similar. | 2014-12-18 |
20140370550 | METHODS FOR AMPLIFYING NUCLEIC ACID USING TAG-MEDIATED DISPLACEMENT - Disclosed are methods for amplifying a nucleic acid target region using an amplification oligomer comprising a target-binding segment and a heterologous displacer tag situated 5′ to the target-binding segment. Initiation of an amplification reaction from the tagged amplification oligomer produces an amplicon comprising the displacer tag, such that once the complement of the displacer tag has been incorporated into a second amplicon, a displacer oligonucleotide having a sequence substantially corresponding to the displacer tag sequence is used to participate in subsequent rounds of amplification for displacement of an extension product primed from a site within the second amplicon 5′ to the displacer priming site. Also disclosed are related kits and reaction mixtures comprising the displacer-tagged amplification oligomer and corresponding displacer oligonucleotide. | 2014-12-18 |
20140370551 | PRODUCTION OF SUGARS AND CO-PRODUCTS FROM CELLULOSIC WASTE STREAMS - This disclosure provides a business method and system for generating sugars and recycling a non-biomass component from a waste stream. In some embodiments, a waste stream comprising cellulose and a non-biomass component is saccharified to produce glucose, followed by recovery of the glucose and non-biomass component, which may be recycled to another site associated with production of a cellulose-containing product that contains the non-biomass component. In certain scenarios, the waste stream is generated at a first location, cellulose pretreatment (if desired) and hydrolysis are conducted at a second location, and the non-biomass component is recycled to the first location or a third location. The non-biomass component may include metals, metal oxides, salts, organic compounds, inorganic compounds, oligomers, or polymers, for example. | 2014-12-18 |
20140370552 | ENDOGLUCANASE 1B (EG1B) VARIANTS - The present invention provides endoglucanase 1b (EG1b) variants suitable for use in saccharification reactions. The present application further provides genetically modified fungal organisms that produce EG1b variants, as well as enzyme mixtures exhibiting enhanced hydrolysis of cellulosic material to fermentable sugars, enzyme mixtures produced by the genetically modified fungal organisms, and methods for producing fermentable sugars from cellulose using such enzyme mixtures. | 2014-12-18 |
20140370553 | Enzymes for Starch Processing - The present invention relates to polypeptides comprising a carbohydrate-binding module amino acid sequence and an alpha-amylase amino acid sequence as well as to the application of such polypeptides. | 2014-12-18 |
20140370554 | NOVEL MUTANT L-ARABITOL DEHYDROGENASE DERIVED FROM NEUROSPORA CRASSA WITH ENHANCED ACTIVITY - The present invention is to enhance the stability and enzyme activity of an L-arabitol dehydrogenase derived from | 2014-12-18 |
20140370555 | METHOD FOR PREPARING (R)-PRAZIQUANTEL - The invention relates to a new method for preparing (R)-praziquantel. In the invention, by taking advantage of the high stereo selectivity, site selectivity and region selectivity of an enzyme, an intermediate of a pure optical and chiral (R)-praziquantel are obtained by means of the dynamic kinetic resolution of an enantiomer from the synthesized racemate or derivatives thereof, and the (R)-praziquantel is obtained by using various conventional and mature organic chemical reactions with higher yield. The method of the invention has the potential advantages of easily available raw materials, low cost, environmentally safer process and convenience for large-scale production. Also, the purity of the end product can be more than 98%. By adopting the invention, the quality of the product is improved and a basis for developing high quality of active pharmaceutical ingredients and formulations is established, and thus the pending industrial problem of purifying praziquantel over 30 years becomes solvable. | 2014-12-18 |
20140370556 | METHOD FOR PREPARING (R)-PRAZIQUANTEL - The invention relates to a new method for preparing (R)-praziquantel. In the invention, by taking advantage of the high stereo selectivity, site selectivity and region selectivity of an enzyme, an intermediate of a pure optical and chiral (R)-praziquantel are obtained by means of the dynamic kinetic resolution of an enantiomer from the synthesized racemate or derivatives thereof, and the (R)-praziquantel is obtained by using various conventional and mature organic chemical reactions with higher yield. The method of the invention has the potential advantages of easily available raw materials, low cost, environmentally safer process and convenience for large-scale production. Also, the purity of the end product can be more than 98%. By adopting the invention, the quality of the product is improved and a basis for developing high quality of active pharmaceutical ingredients and formulations is established, and thus the pending industrial problem of purifying praziquantel over 30 years becomes solvable. | 2014-12-18 |
20140370557 | GENETICALLY ENGINEERED MICROBES AND METHODS FOR PRODUCING 4-HYDROXYCOUMARIN - Provided herein are methods for the biosynthesis of 4-hydroxycoumarin. In one embodiment, provided herein are genetically engineered microbes that include a metabolic pathway for the production of 4-hydroxycoumarin. Also provided are methods for using the genetically engineered microbes to produce 4-hydroxycoumarin, and using the 4-hydroxycoumarin as the starting point for the synthesis of other compounds. | 2014-12-18 |
20140370558 | MODIFYING SOYBEAN OIL COMPOSITION THROUGH TARGETED KNOCKOUT OF THE FAD2-1A/1B GENES - Materials and methods are provided for making soybean varieties that have altered oil composition as a result of mutations in the FAD2-1A and FAD2-1B genes. | 2014-12-18 |
20140370559 | FERMENTATION OF WASTE GASES - The invention relates to the microbial fermentation of gaseous substrates to produce one or more products. The invention relates to the microbial fermentation of a gaseous substrate derived from the conversion of a biogas stream. The invention relates to the conversion of a biogas stream comprising methane to a gaseous substrate comprising CO or CO plus H2, and the production of one or more products from the microbial fermentation of said gaseous substrate. | 2014-12-18 |
20140370560 | BACTERIAL PRODUCTION OF METHYL KETONES - The present invention relates to methods and compositions for increasing production of methyl ketones in a genetically modified host cell that overproduces β-ketoacyl-CoAs through a re-engineered β-oxidation pathway and overexpresses FadM. | 2014-12-18 |
20140370561 | GENETICALLY MODIFIED CLOSTRIDIUM THERMOCELLUM ENGINEERED TO FERMENT XYLOSE - One aspect of the invention relates to industrial bioconversion of the xylose portion of biomass materials into fuels and chemicals. Another aspect of the invention relates to industrial bioconversion of the xylan portion of biomass materials into fuels and chemicals. In one embodiment, the invention is directed to the bacterium | 2014-12-18 |
20140370562 | PRODUCTION OF BETA-PHELLANDRENE USING GENETICALLY ENGINEERED CYANOBACTERIA - The present invention provides methods and compositions for producing β-phellandrene hydrocarbons from cyanobacteria. | 2014-12-18 |
20140370563 | COMPOSITIONS AND METHODS FOR THE RELIEF OF INHIBITION OF ALDEHYDE DECARBONYLASE - The present invention is related to compositions and methods for enhanced synthesis of hydrocarbons, particularly, but not limited to, alkanes. The invention, in one embodiment, utilizes the co-expression of a hydrogen peroxide metabolizing enzyme in the presence of an aldehyde decarbonylase enzyme to relieve hydrogen peroxide inhibition of the aldehyde decarbonylase enzyme by hydrogen peroxide. In a preferred embodiment a catalase-aldehyde decarbonylase expression construct and fusion peptide is used. The present invention also relates to microorganisms engineered to express said enzymes and to produce hydrocarbon molecules. | 2014-12-18 |
20140370564 | MODIFIED MICROORGANISMS AND METHODS OF MAKING BUTADIENE USING SAME - The present disclosure generally relates to microorganisms that comprise one or more polynucleotides coding for enzymes in one or more pathways that catalyze a conversion of a fermentable carbon source to butadiene. Also provided are methods of using the microorganisms in industrial processes including, for use in the production of butadiene and products derived therefrom. | 2014-12-18 |
20140370565 | Production of 1,3-Dienes by Enzymatic Conversion of 3-Hydroxyalk-4-Enoates and/or 3-Phosphonoxyalk-4-Enoates - The present invention relates to a method for generating 1,3-diene compounds through a biological process. More specifically, the invention relates to a method for producing 1,3-diene compounds (for example butadiene or isoprene) from molecules of the 3-hydroxyalk-4-enoate type or from 3-phosphonoxyalk-4-enoates. | 2014-12-18 |
20140370566 | HIGH-NITROGEN LOADING FOR AMMONIA PROCESSING VIA ANAEROBIC DIGESTION - A method and system to improve in vitro anaerobic digestion processes are disclosed. Simultaneous digestion of dairy manures with various food wastes improves anaerobic process stability and methane production. Co-digestion with blood meal and sweet clover (“BMSC”) at the proper concentrations improves nutrient balance and digestion, biogas production, gives more predictable ammonia concentrations, enhances nutrient content of soil amendment products, and increases the potential for production of ammonia-based fertilizer synthesis. Balanced introduction of BMSC with dairy manure increases methane production, reduces or eliminates co-digestion process limitations, and simplifies storage and delivery of the co-substrate. Following digestion, downstream or back-end products can be produced, including methane, and ammonium based fertilizers. Embodiments advantageously provide a treatment methodology for increased methane production while minimizing the anaerobic digestion process limitations from the use of raw animal wastes exclusively. | 2014-12-18 |
20140370567 | DUAL-FUNCTIONAL NONFOULING SURFACES COMPRISING TARGET BINDING PARTNER COVALENTLY COUPLED TO POLYMER ATTACHED TO SUBSTRATE - Dual-functional nonfouling surfaces and materials, methods for making dual-functional nonfouling surfaces and materials, and devices that include dual-functional nonfouling surfaces and materials. The dual-functional surfaces are nonfouling surfaces that resist non-specific protein adsorption and cell adhesion. The dual-functional surfaces and materials include covalently coupled biomolecules (e.g., target binding partners) that impart specific biological activity thereto. The surfaces and materials are useful in medical diagnostics, biomaterials and bioprocessing, tissue engineering, and drug delivery. | 2014-12-18 |
20140370568 | Specialized (iso)eugenol-4-O-methyltransferases (s-IEMTs) and Methods of Making and Using the Same - Specialized (iso)eugenol 4-O-methyltransferase (s-IEMT) enzymes having increased capacity for methylation of monolignols are disclosed. The s-IEMTs have unique activity favoring methylation of coniferyl alcohol versus sinapyl alcohol. Various s-IEMTs methylate ferulic acid. Means for producing the various s-IEMTs are provided. The s-IEMTs are useful for modification of lignin content and production of aromatic compounds. | 2014-12-18 |
20140370569 | EXPRESSION METHOD - In a microbial fermentation, the aim is to increase the product yield of protein. This is achieved by a method in which an expression construct is introduced into a microorganism of the species | 2014-12-18 |
20140370570 | Use of a cysteine protease of Plasmodium vivax - A use of vivapain-4 (VX-4), which is a cysteine protease of | 2014-12-18 |
20140370571 | VERSATILE EXTREMELY THERMOPHILIC BACTERIA FOR THE CONVERSION OF BIOMASS - The present technology pertains to novel isolated xylanolytic, amylolytic and saccharolytic thermophilic bacterial cells belonging to the genus | 2014-12-18 |
20140370572 | MEANS AND METHODS OF INCREASING VIABILITY OF ROD-SHAPED BACTERIA - This invention relates to use of peptone for controlling the volume and/or the length-to-diameter ratio of cells in culture, wherein said cells are cells of rod-shaped probiotic bacteria or rod-shaped fermentation bacteria. | 2014-12-18 |
20140370573 | METHOD FOR PRODUCING ISOPROPANOL AND RECOMBINANT YEAST CAPABLE OF PRODUCING ISOPROPANOL - Isopropanol is produced with good productivity via fermentation processes. Specifically, isopropanol is produced at a high level in a medium by culturing recombinant yeast into which an acetoacetyl CoA synthase gene and a group of genes (isopropanol synthesis-related gene group) encoding a group of enzymes for synthesis of isopropanol from acetoacetyl CoA have been introduced. | 2014-12-18 |
20140370574 | Metabolically Enhanced Cyanobacterial Cell for the Production of Ethanol - A metabolically enhanced cyanobacterial cell for the production of ethanol is provided. The metabolically enhanced cyanobacterial cell for the production of ethanol comprises at least one recombinant gene encoding a pyruvate decarboxylase enzyme (Pdc) converting pyruvate to acetaldehyde, and at least one recombinant gene encoding a first Zn | 2014-12-18 |
20140370575 | GENETICALLY ENHANCED CYANOBACTERIA FOR THE PRODUCTION OF A FIRST CHEMICAL COMPOUND HARBOURING ZN2+, CO2+ OR NI2+ -INDUCIBLE PROMOTERS - One embodiment of the invention is directed to a genetically enhanced cyanobacterium for the production of a first chemical compound, comprising at least one first recombinant gene encoding a first biocatalyst for the production of the first chemical compound, wherein the gene is under the transcriptional control of a Co | 2014-12-18 |
20140370576 | CAPTURE OF CARBON DIOXIDE (CO2) FROM AIR - Disclosed is a method for removing carbon dioxide from a gas stream, comprising placing the gas stream in contact with a resin, wetting the resin with water, collecting water vapor and carbon dioxide from the resin, and separating the carbon dioxide from the water vapor. The resin may be placed in a chamber or a plurality of chambers connected in series wherein the first chamber contains resin that was first contacted by the gas, and each successive chamber contains resin which has been wetted and carbon dioxide collected from for a greater period of time than the previous chamber, and so on, until the last chamber. Secondary sorbents may be employed to further separate the carbon dioxide from the water vapor. | 2014-12-18 |
20140370577 | DRY SCRUBBER SYSTEM WITH BACTERIA - Implementations disclosed herein provide a scrubber system for the reduction and removal of acid gas from a gas stream. The scrubber system includes a dry chemical scrubber having an amount of bacteria therein. A gas stream containing an acid gas contaminant such as H | 2014-12-18 |
20140370578 | MODIFIED CERAMSITE PACKING USEFUL FOR BIOMEMBRANE TRICKLING FILTER AND A PROCESS FOR REMOVING SO2 FROM FLUE GAS USING THE TRICKLING FILTER - A process of removing SO | 2014-12-18 |
20140370579 | Dandelion processes, compositions and products - Dandelion processes, compositions and products are provided. One process is a method of preparing dandelion that utilizes a species of a | 2014-12-18 |
20140370580 | Unitary Biochip Providing Sample-in to Results-out Processing and Methods of Manufacture - A biochip for the integration of all steps in a complex process from the insertion of a sample to the generation of a result, performed without operator intervention includes microfluidic and macrofluidic features that are acted on by instrument subsystems in a series of scripted processing steps. Methods for fabricating these complex biochips of high feature density by injection molding are also provided. | 2014-12-18 |
20140370581 | MICROFLUIDIC DEVICES FOR FLUID MANIPULATION AND ANALYSIS - The present invention relates to microfluidic devices and methods for manipulating and analyzing fluid samples. The disclosed microfluidic devices utilize a plurality of microfluidic channels, inlets, valves, filter, pumps, liquid barriers and other elements arranged in various configurations to manipulate the flow of a fluid sample in order to prepare such sample for analysis. | 2014-12-18 |
20140370582 | SYSTEM AND METHOD FOR DETERMINING INDIVIDUALIZED MEDICAL INTERVENTION FOR A DISEASE STATE - A system and method for determining individualized medical intervention for a particular disease state, and especially for cancers, that includes the molecular profiling of a biological sample from the patient, determining whether any molecular findings including one or more genes, one or more gene expressed proteins, one or more molecular mechanisms, and/or combinations of such exhibit a change in expression compared to a reference, and identifying a non-specific disease therapy or agent capable of interacting with the genes, gene expressed proteins, molecular mechanisms, or combinations of such molecular findings that exhibited a change in expression. | 2014-12-18 |
20140370583 | Multi-Fluidic Cartridges for Sample Analysis and Methods for Using Same - The invention is directed to multi-fluidic cartridges for sample analysis and to methods of using said cartridges. In one embodiment, the cartridge comprises: (a) a first conduit beginning at a sample entry port for receiving a fluid sample and in fluid communication with one or more sensors; (b) a plurality of rupturable fluidic pouches, each containing a different fluid and in fluid communication with a respective delivery conduit configured for delivering a respective fluid to said first conduit; and (c) at least one pneumatic pump configured to move said fluid sample to said one or more sensors and for transporting at least one of said different fluids to said first conduit. | 2014-12-18 |
20140370584 | SENSOR DEVICE - A sensor device includes a flow path and a metal layer disposed in the flow path. The flow path is configured to allow a sample containing analytes to flow and to allow a carrier to be disposed therein. The carrier has acceptors that are fixed on a surface thereof and specifically bound with the analytes for producing aggregates. The flow path includes an aggregate trapping section at which the analytes locally concentrate to the section. This sensor device has high detection sensitivity with a simple structure. | 2014-12-18 |
20140370585 | ENVIRONMENTAL SAMPLING ARTICLES AND METHODS - The present invention refers to articles for collecting samples from a surface, articles for microbiological analyses of said samples, and methods of use of said articles. The articles include sample collectors, sample housings with optional barrier layers, and sample-ready reagent strips comprising hydrophilic agents to grow and detect microorganisms. The disclosure includes methods to collect, detect, and quantify microorganisms in a surface sample. | 2014-12-18 |
20140370586 | MICROCHIP AND MICROCHIP-TYPE FINE-PARTICLE MEASURING DEVICE - A microchip is provided. The microchip includes an incident surface configured to receive light transmitted from a light source, the light being received from an incident direction and a back surface that is opposite the incident surface, the back surface including a portion that is configured to reflect light transmitted from the light source away from the incident direction. | 2014-12-18 |
20140370587 | INTEGRATED SYSTEM FOR HYDROGEN AND METHANE PRODUCTION FROM INDUSTRIAL ORGANIC WASTES AND BIOMASS - The present invention provides a system that has been devised to overcome the two most important limitations for sustained biological hydrogen production, namely contamination of the microbial hydrogen-producing cultures with methane-producing cultures necessitating frequent re-start-up and/or other methanogenic bacteria inactivation techniques, and the low bacterial yield of hydrogen-producers culminating in microbial washout from the system and failure. The system includes a continuously stirred bioreactor (CSTR) for biological hydrogen production, followed by a gravity settler positioned downstream of the CSTR, which combination forms a biohydrogenator. The biomass concentration in the hydrogen reactor is kept at the desired range through biomass recirculation from the bottom of the gravity settler and/or biomass wastage from the gravity settler's underflow. The gravity setter effluent is loaded with volatile fatty acids, as a result of microbiological breakdown of the influent waste constituents by hydrogen-producing bacteria, and is an excellent substrate for methane-forming bacteria in the downstream biomethanator. | 2014-12-18 |
20140370588 | FILTRATION APPARATUS FOR CONTINUOUS PERFUSION - In one aspect, an apparatus for bioprocessing using a liquid comprises an at least partially flexible vessel for receiving the liquid, and a filter adapted for moving within the liquid. An agitator may also be provided for agitating the liquid, and may be connected to the mixer. The mixer may spin or may not spin about an axis of rotation. | 2014-12-18 |
20140370589 | SUBJECT SELECTION DEVICE AND SUBJECT SELECTION METHOD - A suction tip includes a tip opening, a tubular passage provided with a first selector configured to permit the passage of non-selection subjects included in a collection of subjects sucked through the tip opening, and a capture portion provided on a side of the tubular passage downstream of the first selector in a suction direction of the collection of subjects and configured to capture the non-selection subjects. The capture portion includes a passage hole configured to permit the passage of the non-selection subjects and a storage portion configured to store the non-selection subjects having passed through. | 2014-12-18 |
20140370590 | Purification of Nucleic Acids - The present invention solves the problem of isolating nucleic acids from cells in the presence of the growth medium. The invention is particularly useful for isolating extrachromosomal replicons such as plasmids. Cells are lysed in the presence of the medium in which they were grown and nucleic acids are isolated using a pipette tip column. A liquid handling robot can be used to isolate nucleic acids from multiple samples simultaneously without the need for human intervention. | 2014-12-18 |
20140370591 | BROWN FAT CELL COMPOSITIONS AND METHODS - Methods of developing and using cell lines, such as stem cell lines, for therapeutic or cosmetic use. In one embodiment the cell lines are used to treat a wide range of degenerative and metabolic disorders including, but not limited to, obesity, diabetes, hypertension, and cardiac deficiency. Also described are methods of using such cell lines to screen for compounds that play a role in regulating a variety of processes. | 2014-12-18 |
20140370592 | System for Separating a Cell Sample by Centrifugation and Column Chromatography While Maintaining Sterility - The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder ( | 2014-12-18 |
20140370593 | FLOW CHAMBER ASSEMBLY AND METHODS OF USING THE SAME - A flow chamber assembly for subjecting cells or other biological reagents to laminar flow conditions and methods of using the flow chamber assembly are provided herein. The flow chamber assembly includes a bottom plate having at least one well with a bottom surface adapted to receive the cells or biological reagents, a top plate having at least one flow protrusion positioned and shaped to fit into the well of the bottom plate and a sealing element positioned between the top plate and the bottom plate when the top plate and the bottom plate are attached. The flow chamber assembly is configured to allow for laminar flow of a perfusate across the cells or biological reagents along the bottom surface of the well of the bottom plate. The cells or biological reagents can be exposed to a predetermined level of shear stress. | 2014-12-18 |
20140370594 | BIOLOGICAL CONVERSION OF BIOMASS-DERIVED SUGARS TO VALUE ADDED CHEMICALS - A method of growing a microorganism by culturing the microorganism in a an aqueous solution of carbohydrates containing C6-sugar monomers or C5-sugar monomers, wherein the aqueous solution of carbohydrates is made by reacting biomass or a biomass-derived reactant with a solvent system including a lactone and water, and an acid catalyst. The reaction yields a product mixture containing water-soluble C6-sugar-containing oligomers, C6-sugar monomers, C5-sugar-containing oligomers, C5-sugar monomers, or any combination thereof. The product mixture is then partitioned or extracted to yield an aqueous layer containing the carbohydrates and a substantially immiscible organic layer containing the lactone. The aqueous layer is used for growing the microorganisms. | 2014-12-18 |
20140370595 | Use of Synthetic Scaffolds for the Production of Biosynthetic Pathway Products - The present invention provides methods of producing a product or product precursor of a biosynthetic pathway in a genetically modified host cell. The present invention also provides genetically modified host cells comprising nucleic acids encoding a scaffold polypeptide and nucleic acids comprising nucleotide sequences encoding two or more enzymes in a biosynthetic pathway. The present invention further provides nucleic acids comprising nucleotide sequences encoding scaffold polypeptides, for use in a subject method. | 2014-12-18 |
20140370596 | Neural Stem Cells - A homogenous, symmetrically dividing population of adherent neural stem cells is obtained from ES cells or foetal or adult brain isolates, using an activator of a signalling pathway downstream of a receptor of the EGF receptor family, optionally in combination with an activator of a signalling pathway downstream of an FGF receptor. The neural stem cell population is highly pure and retains the ability to differentiate into neurons after in excess of 100 passages. | 2014-12-18 |
20140370597 | RNA INTERFERENCE FOR THE TREATMENT OF GAIN-OF-FUNCTION DISORDERS - The present invention relates to the discovery of an effective treatment for a variety of gain-of-function diseases, in particular, Huntington's disease (HD). The present invention utilizes RNA Interference technology (RNAi) against polymorphic regions in the genes encoding various gain-of-function mutant proteins resulting in an effective treatment for the gain-of-function disease. | 2014-12-18 |
20140370598 | ARTICLES AND METHODS FOR STEM CELL DIFFERENTIATION - Articles and methods for stem cell differentiation are generally described. In some embodiments, an article for stem cell differentiation may comprise an oxygen permeable substrate having at least a portion of a surface coated with a matrix. The matrix may allow the surface chemistry of the substrate to be altered, such that the cell-substrate surface interactions may be finely controlled without substantially affecting the oxygen permeability of the substrate. The surface chemistry may be altered to promote directed stem cell differentiation by, e.g., modification of the matrix surface with a specific density of biological molecules. In some embodiments, methods for stem cell differentiation may comprise directing the differentiation of stem cells on the articles, described herein, under suitable environmental conditions. Articles and methods, described herein, may be free of xenogeneic components and particularly well-suited for applications involving the differentiation of human stem cells into specific lineages. | 2014-12-18 |
20140370599 | METHOD FOR PREPARING BIOLOGICAL TISSUES FOR USE IN BIOLOGICAL PROSTHESES - A method of treating a biological tissue for biological prostheses includes steps of fixation of the biological tissue via a fixing solution including glutaraldehyde and detoxification of the fixed biological tissue via treatment with a detoxifying solution. The detoxification step includes one or both of eliminating phospholipids via treatment with an elimination solution and a treatment with a detoxifying solution. The elimination solution includes 1,2-octanediol and ethanol. The detoxifying solution includes taurine or homocysteic acid. | 2014-12-18 |
20140370600 | METHOD OF PREPARING MESENCHYMAL STEM CELL BASIC CULTURING MEDIUM, MAKING OF CELLULAR THERAPY PRODUCT WITH MESENCHYMAL STEM CELL BASIC CULTURING MEDIUM, AND THE DIFFERENTIATED ONE BY USING THE MEDIUM - Disclosed is a basic culture medium for mesenchymal stem cells, and a cell therapeutic agent cultured and differentiated using same. The basic culture medium reduces the time taken from collection to mass culturing by increasing the proliferation rate of undifferentiated mesenchymal stem cells derived from an adult tissue such as human marrow and adipose tissue, and also is capable of various differentiations into treating agents for bone-forming cells, for cartilage cells, or for fat cells. | 2014-12-18 |
20140370601 | COMPOSITIONS AND METHODS FOR ENHANCING THE PLURIPOTENCY OF STEM CELLS - Described herein is the finding that increasing the frequency of Zscan4 activation in mouse ES cells not only enhances, but also maintains their developmental potency in long-term cell culture. Particularly disclosed herein is the finding that the constitutive presence of Zscan4-ERT2, even in the absence of its usual activator tamoxifen, can increase the frequency of endogenous Zscan4 activation in ES cells, resulting in the increase of developmental potency of the ES cells. Accordingly, provided herein are Zscan4-ERT2 fusion proteins and nucleic acid molecules and vectors encoding Zscan4-ERT2 fusion proteins. Further provided are methods of prolonging and/or enhancing stem cell plmipotency using the disclosed Zscan4-ERT2 nucleic acid molecules and fusion proteins. | 2014-12-18 |
20140370602 | TROPHECTODERMAL CELL-SPECIFIC GENE TRANSFER METHODS - The present inventors discovered that genes could be introduced specifically into trophectodermal cells with high efficiency, by infecting blastocysts with viral vectors carrying an arbitrary polynucleotide, or by using a nucleic acid transfection reagent in blastocysts, from which zona pellucida (extracellular matrix covering preimplantation early embryos to protect them from infection of viruses and the like) is removed. This method has no risk of infecting cells of the inner cell mass, which develops into a fetus in the future, with the introduced polynucleotide because the trophectoderm serves as a barrier. The present invention provides methods for introducing foreign genes into only placenta but not fetus, which enables rescue of genetically mutant animals from embryonic lethality due to placental abnormality and allows their birth. Furthermore, it is possible to analyze expression and effect of genes that regulate placental formation or placental function by using these methods. | 2014-12-18 |
20140370603 | TRANSGENIC CELLS WITH INCREASED PLASTOQUINONE LEVELS AND METHODS OF USE - Disclosed herein are transgenic cells expressing a heterologous nucleic acid encoding a prephenate dehydrogenase (PDH) protein, a heterologous nucleic acid encoding a homogentisate solanesyl transferase (HST) protein, a heterologous nucleic acid encoding a deoxyxylulose phosphate synthase (DXS) protein, or a combination of two or more thereof. In particular examples, the disclosed transgenic cells have increased plastoquinone levels. Also disclosed are methods of increasing cell growth rates or production of biomass by cultivating transgenic cells expressing a heterologous nucleic acid encoding a PDH protein, a heterologous nucleic acid encoding an HST protein, a heterologous nucleic acid encoding a DXS protein, or a combination of two or more thereof under conditions sufficient to produce cell growth or biomass. | 2014-12-18 |
20140370604 | WATER-BASED STERILIZATION INDICATOR COMPOSITION - Water-based formulations comprising an indicating composition dispersed in water are described. The water-based indicating compositions include an organic Bi(III) compound, a sulfur source, and a carbonate salt. Formulations further including a resin and/or an acidic additive are also described. | 2014-12-18 |
20140370605 | METHOD FOR EXAMINING REACTION LAYER FOR FUEL CELL - The purpose of the present invention is to grasp the state in which hydrophilic groups of an electrolyte are distributed in a reaction layer for fuel cells. Nitric acid groups are bonded to hydrophilic groups (sulfonic acid groups) contained in a reaction layer for fuel cells, and metal ions capable of forming a nitrosyl complex with the nitric acid groups, e.g., ruthenium ions, are introduced into the reaction layer to dye the nitric acid groups bonded to the hydrophilic groups contained in the reaction layer. When the hydrophilic groups have agglomerated, the nitric acid groups bonded thereto also agglomerate. When said nitric acid groups are dyed with ruthenium, the ruthenium also agglomerates to make it possible to examine said nitric acid groups with an electron microscope. | 2014-12-18 |
20140370606 | METHOD FOR ESTIMATING THE DEAD TIME OF A LAMBDA SENSOR OF AN EXHAUST GAS PURIFYING DEVICE - In a method for operating an exhaust gas purifying device, with at least one catalyst for filtering exhaust gas and at least one lambda sensor arranged in the exhaust gas, an end of a time period assigned to a maximum or minimum of a delayed signal value supplied by the lambda sensor is determined in that a variable value tracks the signal value and, if the signal value falls short of or exceeds the variable value by a specific difference value, the end of the time period is determined. The end of a time period is corrected on the basis of the time constant of the delay. | 2014-12-18 |
20140370607 | DIRECT IN SITU MONITORING OF ADSORBENT AND CATALYST BEDS - Methods and devices for directly measuring the degree of saturation or degree of deactivation of an adsorbent and/or catalytic bed are described herein. The devices contain an inlet, an outlet, a catalytic and/or adsorbent bed, and optionally a support bed for supporting the catalytic and/or adsorbent bed. The devices further contain one or more structures attached to the reactor that allow for insertion of one or more sensors into the reactor. The sensor is used to spectroscopically interrogate the adsorbent and/or catalyst in situ, providing real-time information regarding adsorbant saturation and/or catalyst deactivation. The devices and methods described herein can be used to determine the saturation degree of adsorbent materials or catalyst beds that are involved in gas-liquid and liquid-liquid heterogeneous systems, such as those used in scrubbing and extraction. | 2014-12-18 |
20140370608 | STATUS DISPLAYING SAMPLE CARRIERS - An automation system for an in vitro diagnostics environment includes a plurality of intelligent carriers that include onboard processing and navigation capabilities. To aid in operator handling of payloads and carriers, carriers include an electronically rewritable display on a surface visible to an operator. The display can include an LCD, E-ink, or other rewritable display and can utilize color, pattern, or text to convey status information of the payloads to the operator. | 2014-12-18 |
20140370609 | ANALYSIS SYSTEM FOR A BIOLOGICAL SAMPLE - The invention provides for an analysis system ( | 2014-12-18 |
20140370610 | METHODS FOR QUANTITATIVE ANALYSIS OF ASBESTOS IN VERMICULITE-CONTAINING MATERIALS - A method for quantitative analysis of asbestos in vermiculite-containing materials includes a first embodiment which includes washing the sample with water or treating the sample with a low concentration acid to digest gypsum and carbonates, ashing the sample at a low temperature to remove cellulose, therefrom and analyzing the sample. Digestion may be effected before or after ashing. Subsequently, a second subsample may be ashed at low temperature to remove cellulose and refluxed with a concentrated acid followed by refluxing with a base and rinsing with deionized water to wash away gypsum, vermiculite and other soluble components. This is followed by analysis to determine asbestos concentration. In a further embodiment, the residue if the first embodiment may be employed as the second subsample. | 2014-12-18 |
20140370611 | PROCESS FOR DETERMINING THE REACTION MECHANISM OF A REACTION AND ASSOCIATED DEVICE - The method according to the invention includes choosing a reaction presumed reaction mechanism; selecting, for said mechanism, at least one first function characteristic of a thermokinetic property that is invariant with the periodic variation frequency of a control parameter influencing said reaction, the first characteristic function being calculated at least from first-order oscillation amplitudes of the concentration of at least one of the species involved in said reaction. The method includes calculating a plurality of values of the first characteristic function from first-order oscillation amplitudes obtained experimentally and analyzing the calculated values of the first characteristic function to determine whether the first characteristic function is constant based on the calculated values, and if the first characteristic function is constant, assigning the presumed mechanism to said reaction. | 2014-12-18 |
20140370612 | Method and System Implementing Spatially Modulated Excitation or Emission for Particle Characterization with Enhanced Sensitivity - A method and system for using spatially modulated excitation/emission and relative movement between a particle (cell, molecule, aerosol, . . . ) and an excitation/emission pattern are provided. In at least one form, an interference pattern of the excitation light with submicron periodicity perpendicular to the particle flow is used. As the particle moves along the pattern, emission is modulated according to the speed of the particle and the periodicity of the stripe pattern. A single detector, which records the emission over a couple of stripes, can be used. The signal is recorded with a fast detector read-out in order to capture the “blinking” of the particles while they are moving through the excitation pattern. This concept enables light detection with high signal-to-noise ratio and high spatial resolution without the need of expensive and bulky optics. | 2014-12-18 |
20140370613 | Atmospheric Pressure Chemical Ionization Detection - An atmospheric pressure chemical ionization detector includes a reaction chamber that is configured to receive gas phase analytes. An electrode is disposed within the reaction chamber and is configured to ionize the gas phase analytes via corona discharge. A collector is disposed adjacent an outlet of the reaction chamber and is configured to attract ions from the chamber such that the ions hit the collector to induce a measurable current. The detector is configured for non-mass spectrometric detection of gas phase analyte ions. | 2014-12-18 |
20140370614 | HILIC / ANION-EXCHANGE / CATION-EXCHANGE MULTIMODAL MEDIA - The present invention provides an agglomerated multimodal chromatographic medium. the medium of the invention includes groups active in anion exchange, cation exchange and hydrophilic interaction chromatographic modalities. The invention provides methods of making these media and using them in separations of analytes. Also provided are separations devices incorporating the medium and systems incorporating these separations devices. | 2014-12-18 |
20140370615 | USE OF OPTICALLY ANISOTROPIC PARTICLES - This invention relates to the use of optically anisotropic particles in order to non-destructively test or determine physical system parameters and/or the microscopic structure of systems. The mobility of the optically anisotropic particles is used to examine physical system parameters and/or the microscopic structure of systems. To this end, particle mobility is measured via an optical system. | 2014-12-18 |
20140370616 | LATERAL FLOW IMMUNOASSAY FOR DETECTING VITAMINS - The invention is directed to a method for detecting analytes, particularly vitamins, using a lateral flow immunoassay. The method may be used to detect vitamin D, particularly 25-hydroxy vitamin D | 2014-12-18 |
20140370617 | APPARATUS AND METHODS FOR DETECTING ANALYTES - The present invention provides an apparatus for retaining solid state reagents and/or for processing sample for a diagnostic test, where the apparatus avoids liquid “hang-up” that would otherwise result in loss of sample or fluid volume during sample transfer. The invention further provides diagnostic methods that employ the apparatus, so as to provide sensitive and accurate analyte detection. | 2014-12-18 |
20140370618 | NUCLEIC ACID MOLECULE HAVING BINDING AFFINITY TO RODENT-DERIVED IGG ANTIBODY, BINDER, DETECTION REAGENT, AND DETECTION KIT - The present invention is to provide a nucleic acid molecule having a binding affinity to a rodent-derived IgG antibody, which can be prepared easier than an antibody and has a binding affinity equivalent or superior to that of an antibody, a binder using the nucleic acid molecule, a detection reagent, and a detection kit. The nucleic acid molecule of the present invention has a binding affinity to a rodent-derived IgG antibody and has a dissociation constant of 1 μM or less. The binder for a rodent-derived IgG antibody of the present invention includes the nucleic acid molecule of the present invention. The detection reagent for detecting a rodent-derived IgG antibody of the present invention includes the binder for a rodent-derived IgG antibody of the present invention. The detection kit for detecting a rodent-derived IgG antibody of the present invention includes the detection reagent for detecting a rodent-derived IgG antibody of the present invention. | 2014-12-18 |
20140370619 | METHODS FOR DIAGNOSING ALZHEIMER'S DISEASE - The present invention relates to methods of diagnosing, monitoring, and assessing treatment effects for Aβ amyloidosis, early in the course of clinical disease or prior to the onset of brain damage and clinical symptoms. Methods of measuring the in vivo metabolism of biomolecules produced in the CNS in a subject are provided. | 2014-12-18 |
20140370620 | MULTIMER TYPE DISCRIMINATION AND DETECTION METHOD FOR MULTIMER-FORMING POLYPEPTIDE - The present invention relates to a method for selectively detecting a multimer type multimer-forming polypeptide in a biological sample, the method comprising: (a) bringing the biological sample into contact with an agglutination reaction inducing agent to induce the formation of an aggregate in an analysis target, the agglutination reaction inducing agent being a particle in which a specific antibody is surface-bonded with the multimer-forming polypeptide; (b) obtaining an image with respect to the aggregate of step (a); and (c) analyzing a size or a shape of the aggregate by using the image. Step (a), step (b), or steps (a) and (b) are performed on a microchip having a microchannel. The image analysis is performed using a coefficient according to the size of the aggregate in a predetermined volume provided by the microchannel. In the case where the multimer type of multimer-forming polypeptide is present in the biological sample, the size of the aggregate is larger than the size of an aggregate of a monomer type control group. According to the present invention, unlike in a detection method using chemiluminescence immunoanalysis of the related art, an image with respect to an agglutination reaction target is obtained and then a size or a shape of an aggregate is analyzed so as to determine whether or not an analysis target is present in a biological sample and to determine the quantity of the analysis target. Also, it is possible to detect a multimer type multimer-forming polypeptide by just analyzing an image acquired from the sample so that the detection process is made more convenient and quick. | 2014-12-18 |
20140370621 | FERROELECTRIC CAPACITOR ENCAPSULATED WITH A HYDROGEN BARRIER - An integrated circuit containing a ferroelectric capacitor, an underlying hydrogen barrier, and an overlying hydrogen barrier layer. A method for forming an integrated circuit containing a ferroelectric capacitor, an underlying hydrogen barrier, and an overlying hydrogen barrier layer. | 2014-12-18 |
20140370622 | MANUFACTURING METHOD FOR ORGANIC EL LIGHTING DEVICE - Anodes of a plurality of organic EL elements are connected together. A forward bias voltage relative to the potential of anodes and a reverse bias voltage are alternately applied to cathodes of the plurality of organic EL elements at a predetermined period. The ratio of the time for which the reverse bias voltage is applied and the time for which the forward bias voltage is applied is increased. | 2014-12-18 |
20140370623 | EVAPORATION APPARATUS AND METHOD - An evaporation apparatus comprises a chamber configured to contain at least one dispensing nozzle and at least one substrate to be coated. The chamber has at least one adjustable shielding member defining an adjustable aperture. The member is positioned between the at least one dispensing nozzle and the at least one substrate. The aperture is adjustable in at least one of the group consisting of area and shape. The at least one adjustable shielding member has a heater. | 2014-12-18 |
20140370624 | WAFER ALIGNMENT AND BONDING TOOL FOR 3D INTEGRATION - A bonding apparatus for 3D integration may include a plurality of infrared microscopes that emit and receive infrared light for imaging, a first bonding chuck that holds a first semiconductor structure, and a second bonding chuck that holds a second semiconductor structure, whereby the second bonding chuck has a plurality of openings that are transparent to the received infrared light. A force pin is coupled to the first bonding chuck for applying a predetermined force to the first semiconductor structure for bonding to the second semiconductor structure. A temperature controller is coupled to the second bonding chuck, whereby the temperature controller applies a predetermined temperature to the second semiconductor structure, such that, prior to the bonding, the first and the second semiconductor structure are de-aligned with respect to each other using the plurality of infrared microscopes and the plurality of openings. The de-alignment is based on the predetermined force and the application of the predetermined temperature. | 2014-12-18 |
20140370625 | Stopping An Etch In A Planar Layer After Etching A 3D Structure - A method of etching including providing a plurality of nanostructures extending away from a support, the support comprising a dielectric layer located between the plurality of nanowires, forming a patterned mask over a first portion of the plurality of nanostructures, such that a second portion of the plurality of nanostructures are exposed and are not located under the patterned mask, etching the second portion of the plurality of nanostructures to remove at least a portion of the patterned mask and the second portion of the plurality of nanostructures, monitoring at least one gaseous byproduct of the etching of the plurality of nanostructures during the etching of the plurality of nanostructures and stopping the etching on detecting that the dielectric layer is substantially removed. | 2014-12-18 |
20140370626 | METHOD OF MANUFACTURING ORGANIC LIGHT EMITTING DISPLAY DEVICE USING ORGANIC LAYER DEPOSITION APPARATUS - A method of manufacturing an organic light-emitting display device is provided. An alignment master member is loaded on a moving unit. An organic layer deposition assembly is pre-aligned to the alignment master member. After the pre-aligning of the organic layer deposition assembly, a substrate is loaded on the moving unit. The organic layer deposition assembly is aligned to the substrate positioned as is after the loading of the substrate. An organic layer is formed on the substrate while the moving unit is moving along the moving direction. While the moving unit is moving along the moving direction, the organic layer deposition assembly is adjusted so that an interval between the organic layer deposition assembly and part of the substrate is maintained as substantially constant. The part of the substrate receives a deposition material emitted from the organic layer deposition assembly to form the organic layer. | 2014-12-18 |
20140370627 | MONITORING LASER PROCESSING OF SEMICONDUCTORS BY RAMAN SPECTROSCOPY - A Raman probe is used to detect crystal structure of a substrate undergoing thermal processing in a thermal processing system. The Raman probe may be coupled to a targeting system of a laser thermal processing system. The Raman probe includes a laser positioned to direct probe radiation through the targeting system to the substrate, a receiver attuned to Raman radiation emitted by the substrate, and a filter that blocks laser radiation reflected by the substrate. The Raman probe may include more than one laser, more than one receiver, and more than one filter. The Raman probe may provide more than one wavelength of incident radiation to probe the substrate at different depths. | 2014-12-18 |
20140370628 | SUBSTRATE PROCESSING APPARATUS, SEMICONDUCTOR DEVICE MANUFACTURING METHOD, SUBSTRATE PROCESSING METHOD, AND RECORDING MEDIUM - According to the present disclosure, it is possible to prevent particles from being generated and to improve substrate processing quality. A substrate processing apparatus includes cassette mounting unit on which process substrate cassette and dummy substrate cassette are mounted, the process substrate cassette being configured to accommodate a plurality of process substrates, and the dummy substrate cassette being configured to accommodate a plurality of dummy substrates, process chamber configured to process the process substrates and the dummy substrates, substrate support unit installed within the process chamber and provided with a plurality of substrate mounting portions where the process substrates and the dummy substrates are mounted, transfer unit configured to transfer the process substrates and the dummy substrates between the cassette mounting unit and the process chamber, and control unit configured to control substrate processing and to transfer processing of the process substrates and the dummy substrates. | 2014-12-18 |
20140370629 | Method of Manufacturing a Printable Composition of a Liquid or Gel Suspension of Diodes - An exemplary printable composition of a liquid or gel suspension of diodes comprises a plurality of diodes, a first solvent and/or a viscosity modifier. An exemplary method of making a liquid or gel suspension of diodes comprises: adding a viscosity modifier to a plurality of diodes in a first solvent; and mixing the plurality of diodes, the first solvent and the viscosity modifier to form the liquid or gel suspension of the plurality of diodes. Various exemplary diodes have a lateral dimension between about 10 to 50 microns and about 5 to 25 microns in height. Other embodiments may also include a plurality of substantially chemically inert particles having a range of sizes between about 10 to about 50 microns. | 2014-12-18 |
20140370630 | METHOD FOR MANUFACTURING SEMICONDUCTOR LIGHT EMITTING DEVICE - A semiconductor light emitting device having high reliability and excellent light distribution characteristics can be provided with an n-electrode arranged on a light extraction surface on the side opposite to the surface whereupon a semiconductor stack is mounted on a substrate. A plurality of convexes are arranged on a first convex region and a second convex region on the light extraction surface. The second convex region adjoins the interface between the n-electrode and the semiconductor stack, between the first convex region and the n-electrode. The base end of the first convex arranged in the first convex region is positioned closer to a light emitting layer than the interface between the n-electrode and the semiconductor stack, and the base end of the second convex arranged in the second convex region is positioned closer to the interface between the n-electrode and the semiconductor stack than the base end of the first convex. | 2014-12-18 |
20140370631 | REMOVAL OF 3D SEMICONDUCTOR STRUCTURES BY DRY ETCHING - Various embodiments include methods of fabricating a semiconductor device that include providing a plurality of nanostructures extending away from a support, forming a flowable material layer between the nanostructures, forming a patterned mask over a first portion of the flowable material and the first portion of the plurality of nanostructures, such that a second portion of the flowable material and a second portion of the plurality of nanostructures are not located under the patterned mask and etching the second portion of the flowable material and the second portion of the plurality of nanostructures to remove the second portion of the flowable material and the second portion of the plurality of nanostructures to leave the first portion of the flowable material and the first portion of the plurality of nanostructures unetched. | 2014-12-18 |
20140370632 | TFT AND LCD PANEL AND METHOD FOR MANUFACTURING THE SAME - The present invention discloses a TFT, an LCD panel and method for manufacturing the same. In the LCD panel, a transparent conducting layer forms a first electrode of a TFT and a second electrode of a TFT directly, and the transparent conducting layer also serves as a connecting line between a TFT and a data line and between a TFT and an LC capacitor. So it is not necessary to form a via hole over the TFT to link the TFT and the transparent conducting layer. In this way, an area of a pixel electrode can be further extended, and the aperture rate of an LCD panel can be also increased, raising a transmittance of light from light sources passing through the pixel electrode In this way, not only a design in pixels becomes more flexible but also the aperture rate of an LCD panel becomes higher. | 2014-12-18 |
20140370633 | ORGANIC LAYER DEPOSITION APPARATUS AND METHOD OF MANUFACTURING ORGANIC LIGHT-EMITTING DISPLAY DEVICE BY USING THE ORGANIC LAYER DEPOSITION APPARATUS - An organic layer deposition apparatus includes: a conveyer unit including a transfer unit, a first conveyer unit, and a second conveyer unit; a loading unit for fixing a substrate to the transfer unit; a deposition unit including a chamber and at least one organic layer deposition assembly; and a measuring unit located between the loading unit and the deposition unit to measure position information of the substrate before an organic layer is deposited onto the substrate; and an unloading unit for separating, from the transfer unit, the substrate onto which the deposition has been completed, wherein the transfer unit is configured to cyclically move between the first conveyer unit and the second conveyer unit, and wherein the substrate fixed to the transfer unit is configured to be spaced apart from the at least one organic layer deposition assembly while being transferred by the first conveyer unit. | 2014-12-18 |
20140370634 | METHOD FOR FABRICATING NITRIDE SEMICONDUCTOR THIN FILM AND METHOD FOR FABRICATING NITRIDE SEMICONDUCTOR DEVICE USING THE SAME - A method for fabricating a nitride semiconductor thin film includes preparing a first nitride single crystal layer doped with an n-type impurity. A plurality of etch pits are formed in a surface of the first nitride single crystal layer by applying an etching gas thereto. A second nitride single crystal layer is grown on the first nitride single crystal layer having the etch pits formed therein. | 2014-12-18 |
20140370635 | METHOD OF MANUFACTURING AN ORGANIC LIGHT EMITTING STRUCTURE AND METHOD OF MANUFACTURING AN ORGANIC LIGHT EMITTING DISPLAY DEVICE - A method of manufacturing an organic light emitting structure is provided as follows. A first electrode is formed on a lower substrate. A pixel defining layer is formed adjacent to the first electrode on the lower substrate. A preliminary charge transport layer is formed on the first electrode and the pixel defining layer. An organic light emitting layer is formed on the preliminary charge transport layer. The preliminary charge transport layer is selectively etched to form a charge transport layer. A second electrode is formed on the organic light emitting layer. | 2014-12-18 |
20140370636 | EXTENDED GATE SENSOR FOR pH SENSING - A sensing device includes a substrate having a source region and a drain region formed therein. A gate structure is formed over the substrate and includes a gate dielectric and a gate conductor. The gate conductor is formed on the gate dielectric and disposed between the source region and the drain region. A dielectric layer is formed over the substrate and has a depth configured to form a well over the gate conductor. A gate extension is formed in contact with or as part of the gate conductor and including a conductive material covering one or more surfaces of the well. | 2014-12-18 |
20140370637 | NANOCHANNEL PROCESS AND STRUCTURE FOR BIO-DETECTION - Nanochannel sensors and methods for constructing nanochannel sensors. An example method includes forming a sacrificial line on an insulating layer, forming a dielectric layer, etching a pair of electrode trenches, forming a pair of electrodes, and removing the sacrificial line to form a nanochannel. The dielectric layer may be formed on insulating layer and around the sacrificial line. The pair of electrode trenches may be etched in the dielectric layer on opposite sides of the sacrificial line. The pair of electrodes may be formed by filling the electrode trenches with electrode material. The sacrificial line may be removed by forming a nanochannel between the at least one pair of electrodes. | 2014-12-18 |
20140370638 | MEMS STRUCTURE WITH IMPROVED SHIELDING AND METHOD - A method for fabricating an integrated MEMS-CMOS device. The method can include providing a substrate member having a surface region and forming a CMOS IC layer having at least one CMOS device overlying the surface region. A bottom isolation layer can be formed overlying the CMOS IC layer and a shielding layer and a top isolation layer can be formed overlying a portion of bottom isolation layer. The bottom isolation layer can include an isolation region between the top isolation layer and the shielding layer. A MEMS layer overlying the top isolation layer, the shielding layer, and the bottom isolation layer, and can be etched to form at least one MEMS structure having at least one movable structure and at least one anchored structure. | 2014-12-18 |
20140370639 | MICRO ELECTRO MECHANICAL SYSTEM, SEMICONDUCTOR DEVICE, AND MANUFACTURING METHOD THEREOF - The present invention provides a MEMS and a sensor having the MEMS which can be formed without a process of etching a sacrifice layer. The MEMS and the sensor having the MEMS are formed by forming an interspace using a spacer layer. In the MEMS in which an interspace is formed using a spacer layer, a process for forming a sacrifice layer and an etching process of the sacrifice layer are not required. As a result, there is no restriction on the etching time, and thus the yield can be improved. | 2014-12-18 |
20140370640 | HIGH FIDELITY DOPING PASTE AND METHODS THEREOF - A high-fidelity dopant paste is disclosed. The high-fidelity dopant paste includes a solvent, a set of non-glass matrix particles dispersed into the solvent, and a dopant. | 2014-12-18 |
20140370641 | PROCESSING PHOTOVOLTAIC SUBSTRATES - A method for processing a coated glass substrate may include a high-temperature activation process. | 2014-12-18 |