51st week of 2015 patent applcation highlights part 23 |
Patent application number | Title | Published |
20150361369 | Microwave Produced Biochar from Beneficiated Organic-Carbon-Containing Feedstock - A processed biochar composition made with an oxygen-starved microwave sub-system from a processed organic-carbon-containing feedstock made with a beneficiation sub-system is described. Renewable biomass feedstock passed through a beneficiation sub-system to reduce water content to below at least 20 wt % and water-soluble salt reduction of at least 60% from that of unprocessed organic-carbon-containing feedstock on a dry basis. The processed feedstock is introduced into a substantially microwave-transparent reaction chamber. A microwave source emits microwaves which are directed through the microwave-transparent wall of the reaction chamber to impinge on the feedstock within the reaction chamber. The microwave source may be rotated relative to the reaction chamber. The feedstock is subjected to microwaves until the desired reaction occurs to produce a solid processed biochar fuel. | 2015-12-17 |
20150361370 | Aggregates of Cleaned Low Energy Coal Fines and Beneficiated Organic-Carbon-Containng Feedstock - A processed biomass/coal blended compact aggregate composition made with a blending sub-system from a processed organic-carbon-containing feedstock made with a beneficiation sub-system and low energy coal is described. Renewable biomass feedstock passed through a beneficiation sub-system to produce a processed biomass with an energy density of at least 17 MMBTU/ton (19 GJ/MT), a water content of below at least 20 wt % and an intracellular water-soluble salt that is at least 60% below that of unprocessed organic-carbon-containing feedstock on a dry basis. Low energy un-cleaned coal is sized and passed through a coal cleaning sub-system to result in cleaned low energy coal having an energy density of less than 21 MMBTU/ton (24 GJ/MT) and a content of sulfur that is at least 50 wt % below that of the content of sulfur in the coal before it passed through the coal cleaning sub-system. The processed feedstock is sized and blended with the cleaned low energy coal in a blending sub-system to form a blended aggregate that comprises at least 10 wt % of the cleaned low energy coal and at least 10 wt % of the processed biomass. | 2015-12-17 |
20150361371 | HYDROTHERMAL CARBONIZATION OF ALGAL FEEDSTOCKS AND FUELS PRODUCED THEREBY - In one embodiment, the present disclosure provides a method for producing a solid fuel. A feedstock that includes algae or delipidized algal residue and a liquid carrier is heated to a suitable temperature, at a suitable pressure, and for a suitable amount of time to form a desired amount of solid hydrochar. The hydrochar is collected and compressed into a compressed solid. | 2015-12-17 |
20150361372 | Hydrothermal Conversion Process - A hydrothermal conversion process includes a mixing step wherein an aqueous slurry of a solid feedstock material with a steam stream to produce a reaction mixture having a temperature of at least 160° C. and which is at a pressure sufficient to keep water as a subcooled liquid. The process is fast and effective, requires only simple equipment and is highly energy-efficient. The process is also readily scalable, can be operated continuously or semi-continuously and can be tailored to produce carbonized solids or liquefaction products, all of which typically have increased economic value compared with the starting materials. | 2015-12-17 |
20150361373 | PROCESS FOR CLARIFYING BIOFUELS - Haze may be removed from a biofuel or biofuel intermediate by using a clarifier. The clarifier includes copolymer prepared using a formulation comprising an alpha olefin and maleic anhydride. The clarifier may also be used with admixtures of biofuels, biofuel intermediates, or biofuel feedstocks with conventional hydrocarbons. | 2015-12-17 |
20150361374 | CATALYTIC DEPOLYMERISATION OF POLYMERIC MATERIALS - A process for converting a molten polymeric material is provided. The process includes effecting disposition of a molten polymeric material, having at least one carbon-carbon double bond, in sufficient proximity to a catalyst material within a reaction zone, to effect a reactive process that effects generation of a reaction product. The reactive process effects cleaving of at least one carbon-carbon double bond. The catalyst material includes [Fe—Cu—Mo—P]/Al | 2015-12-17 |
20150361375 | Nanoparticle compositions and greaseless coatings for equipment - A composition that includes solid lubricant nanoparticles and an organic medium is disclosed. Also disclosed are nanoparticles that include layered materials. A method of producing a nanoparticle by milling layered materials is provided. Also disclosed is a method of making a lubricant, the method including milling layered materials to form nanoparticles and incorporating the nanoparticles into a base to form a lubricant. | 2015-12-17 |
20150361376 | METHODS FOR EXTRACTING SOLUTE FROM A SOURCE MATERIAL - Methods for extracting solute from a source material are shown and described. The methods each include: depositing the source material in a canister, introducing a solvent, exposing the source material to the solvent to create an extract mixture, communicating the extract mixture to one or more extract containers, separating the solute from the extract mixture by heating the extract containers, collecting the recycled solvent in a solvent collection container, and cooling the recycled solvent within the solvent collection container. In some examples, the one or more extract containers are first and second extract containers that are each selectively coupleable to the canister and are selectively removable for storage of the extract mixture. In some other examples, cooling the recycled solvent within the solvent collection container is carried out via a cooling mechanism coupled to the solvent storage container. | 2015-12-17 |
20150361377 | LOW VOLATILE ORGANIC COMPOUNDS CLEANER COMPOSITION - Disclosed herein are low volatile organic compound cleaner compositions which include a diethylene glycol monoalkyl ether, benzyl alcohol, and a fluorosurfactant. Also disclosed are low volatile organic compound cleaner compositions which include a diethylene glycol monoalkyl ether, benzyl alcohol, and an ethanolamine Methods of using the compositions are also provided. | 2015-12-17 |
20150361378 | CLEANING SOLUTION, CLEANING TOOL, AND CLEANING KIT - A cleaning solution is used, in a transparent antireflective structure that has, on one surface thereof, a plurality of convexities formed at a period equal to or shorter than wavelength in a visible light range, and that prevents, at the one surface, reflection of light entering the one surface, to clean a concavity defining a region between adjacent two of the plural convexities, the cleaning solution having a pH of 10.00 or more. | 2015-12-17 |
20150361379 | FORMULATIONS, THEIR USE AS OR FOR PRODUCING DISHWASHING DETERGENTS AND THEIR PRODUCTION - Formulation comprising
| 2015-12-17 |
20150361380 | LEATHER AND/OR VINYL CLEANER AND MOISTURIZER AND METHOD OF MAKING SAME - The present invention comprises a hard surface cleaning and treatment composition with a synergistic combination of mild surfactants that makes the composition particularly suited for leather, synthetic leather, vinyl and stainless steel. The composition is gentle and non-damaging to leather and synthetic leather, and leaves no sticky residue. The composition can clean food soils such as mustard, ketchup, shortening and grease and requires no personal protective equipment when being used. In addition, a method of preserving a leather surface or article by contacting said surface with said substrate is disclosed as well as specific methods associated with making the composition to form a stable water in oil emulsion. | 2015-12-17 |
20150361381 | AQUEOUS FORMULATIONS, THEIR MANUFACTURE, AND THEIR USE IN HARD SURFACE CLEANING - The present invention is directed towards aqueous formulations comprising (A) at least one alkoxylated polypropylenimine, (B) at least one non-ionic surfactant, selected from (B1) alkyl polyglycosides and (B2) alkoxylated C | 2015-12-17 |
20150361382 | A METHOD FOR COATING METALLIC SURFACES FOR PREVENTING PINHOLES ON ZINC-CONTAINING METALLIC SURFACES - A method of using a silane additive in an aqueous cleaning composition, in an aqueous rinsing liquid and/or in an aqueous activation composition for preventing pinholes on zinc-containing metallic surfaces, wherein the silane content in at least one of these aqueous compositions is in a range of 0.001 to 5 g/l. | 2015-12-17 |
20150361383 | ENHANCED CATALYST STABILITY IN ACTIVATED PEROXYGEN AND/OR ALKALINE DETERGENT FORMULATIONS - Stabilized catalyst detergent compositions are provided in solid formulations of detergents including an active oxygen source and/or a highly alkaline detergent composition. The compositions are suitable for use with additional detergent and/or bleaching compositions while providing stabilized catalysts within a polymeric matrix. Methods or process for manufacturing the compositions, and methods of use for cleaning are disclosed. | 2015-12-17 |
20150361384 | METHOD AND APPARATUS FOR MAKING SOAP - The present invention is directed towards a method and apparatus for making soap. According to one embodiment, a soap making apparatus comprises a water vessel that holds water, an oil vessel that holds an oil mixture, a lye container that accepts enclosed lye capsules and a microcontroller that controls a mixture of ingredients that is discharged from the water vessel, oil vessel and lye vessel to produce one or more soap bars made. | 2015-12-17 |
20150361385 | ENHANCED CATALYST STABILITY FOR ALKALINE DETERGENT FORMULATIONS - Stabilized catalyst detergent compositions are provided in solid alkaline detergent formulations are disclosed. The compositions are suitable for use with additional detergent and/or bleaching compositions while providing stabilized catalysts within an encapsulated cellulose derivative coating. Methods of use for cleaning are disclosed. | 2015-12-17 |
20150361386 | Biomimetic Device - Described herein are apparatus comprising: a first layer comprising a first microfluidic channel; a second layer comprising a second microfluidic channel; and a membrane for culturing cells; along with methods of making and using same. | 2015-12-17 |
20150361387 | BIOCHEMICAL CARTRIDGE, AND BIOCHEMICAL CARTRIDGE AND CARTRIDGE HOLDER SET - A cartridge sealed from ambient air is used to send a liquid without causing the liquid to contact the fluid inside the cartridge. Inside of the cartridge | 2015-12-17 |
20150361388 | ULTRASONIC APPARATUS AND METHOD FOR CELL RELEASE - An apparatus ( | 2015-12-17 |
20150361389 | MICROBIAL EXPERIMENT COOLING AND TEMPERATURE-SENSING MULTIPURPOSE RACK - A multi-function cooling and thermo-sensitive rack includes horizontal bars, a base, positioning holes, connectors, a lateral frame, connecting holes, a temperature-displaying prompter, and N temperature sensors. The lateral frame and the base are connected through the connectors. The lateral frame and the base have their surfaces facing each other symmetrically provided with plural connecting holes thereon. The horizontal bars have two ends thereof received in the corresponding symmetrical connecting holes. The positioning holes are distributed over the surface of the base. The N temperature sensors have output ends thereof for outputting sensing signals connected with input ends of the temperature-displaying prompter for inputting the N temperature-sensing signals. The present invention is applied to apparatuses used in microbiology experiment. | 2015-12-17 |
20150361390 | COMPOSITION AND METHOD FOR GENERATING A DESIRED CELL TYPE AND/OR TISSUE TYPE FROM HAIR FOLLICULAR STEM CELLS - The present invention is concerned with a composition and in vitro method for generating a desired cell type and/or tissue type from hair follicular stem cells. The composition and in vitro method are particularly suitable for generating an autologous desired cell type and/or tissue type. Furthermore, the composition and method are especially efficient and suitable for use in the context of cosmetic cell and/or tissue transplantation in recipient areas of a subject experiencing cell and/or tissue loss caused by, for example, a wound, scar, burn injury, tissue degeneration, and aging. The composition and in vitro method are also suitable to circumvent complications related to infections and/or immune rejection of a cosmetic cell and/or tissue implant or graft. | 2015-12-17 |
20150361391 | METHOD FOR INDUCING TAILORED PLURIPOTENT STEM CELLS USING EXTRACT OF PLANT STEM CELLS OR PLANT DEDIFFERENTIATED STEM CELLS, AND PLURIPOTENT STEM CELLS PRODUCED BY MEANS OF THE METHOD - A method for inducing tailored pluripotent stem cells by reprogramming differentiated cells of an adult by using an extract of plant stem cells and plant dedifferentiated stem cells (callus); pluripotent stem cells produced by means of the method; and a cell therapy agent comprising the pluripotent stem cells are disclosed. It is possible to overcome ethical problems since eggs are not used in the making of pluripotent stem cells having abilities like embryonic stem cells. It is possible to produce pluripotent stem cells of ensured safety because a plant stem cell extract which above all has been verified to be harmless to the body is used. It is possible to develop an immunocompatible cell therapy agent tailored to different individuals. | 2015-12-17 |
20150361392 | LIQUID CULTURING OF EPITHELIAL STEM CELLS - Provided herein is a method of culturing epithelial stem cells and tissue fragments comprising epithelial stem cells in liquid cultures. | 2015-12-17 |
20150361393 | In Vitro Production of Medial Ganglionic Eminence Precursor Cells - Methods and systems for generating MGE precursor cells in vitro as well as compositions of enriched MGE precursor cells are provided. The methods and systems provide efficient production of MGE precursors. The methods and systems disclosed herein provide functional MGE precursors which differentiate into functional GABAergic interneurons. | 2015-12-17 |
20150361394 | CELL-TO-CELL COMMUNICATION WITHOUT EXCHANGE OF MEDIATING DIFFUSIBLE FACTORS OR USING ANY PHYSICAL CONTACT BETWEEN CELLS - The present invention departs from using traditional modes of cell-to-cell communication and concerns exerting influence on a first cell or cell population by bringing a second cell or cell population into proximity with the first cell population without the use of mediating diffusible factors. Cell to cell communications traditionally occur by way of a variety of mechanisms including, for example, by direct coupling through gap junctions using antigen presentation or using ligand receptor interactions. | 2015-12-17 |
20150361395 | GROWTH MATRICES FOR STEM CELL PROPAGATION IN VITRO AND IN TISSUE REGENERATION - The present invention provides a multifunctional 2-D and 3-D matrix for propagation of stem cells. In particular, a chitosan-based biomaterial scaffold is engineered to promote CNS regeneration from primitive neural precursors by stabilizing a recombinant protein, fibroblast growth factor to preserve the cardinal properties of stem cells. The matrix, is further modified by the addition of either the extracellular matrix protein fibronectin or the small peptide RGD or IKVAV. A method to manufacture an injectable multifunctional microsphere scaffold is also disclosed that is suitable as a vehicle for cell transplantation to repair traumatic brain injuries. | 2015-12-17 |
20150361396 | T CELL BALANCE GENE EXPRESSION, COMPOSITIONS OF MATTERS AND METHODS OF USE THEREOF - This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications. | 2015-12-17 |
20150361397 | METHOD FOR GENERATION OF REGULATORY T-CELLS USING FACTORS SECRETED BY iNKT CELLS - The current invention concerns the use of PIP or S100A8 for the generation of regulatory T cells. The current invention provides a method of generating regulatory T cells by contacting immature DC with PIP or S100A8 to produce tolerogenic DC and further contacting naïve T cells to the tolerogenic DC to produce regulatory T cells. The invention also concerns PIP protein where immature DC contacted with PIP produce tolerogenic DC that induce conversion of naïve T-cells into regulatory T cells. The invention also concerns S100A8 protein where immature DC contacted with S100A8 produce tolerogenic DC that induce conversion of naïve T-cells into regulatory T cells. The invention also provides methods for identification of factors secreted by iNKT cells that induce conversion of immature DC into tolerogenic DC. The subject invention also concerns using regulatory T cells for treatment and/or management of cancer or the diseases of the immune system. | 2015-12-17 |
20150361398 | REPROGRAMMING OF HUMAN ENDOTHELIUM INTO HEMATOPOIETIC MULTI-LINEAGE PROGENITORS BY DEFINED FACTORS - The invention is directed to generation of hematopoietic multi-lineage progenitors (HMLPs) from endothelial cells (ECs) by effecting forced expression of certain transcription factors in the ECs and culturing the ECs in serum free media in the presence of endothelial feeder cells. The HMLPs generated in accordance with this invention can produce erythroid, lymphoid, myeloid, and megakaryocyte cells. These generated HMLPs can be used in therapeutic treatment of disorders including hematopoietic conditions. | 2015-12-17 |
20150361399 | CARDIOMYOCYTE DIFFERENTIATION - This invention provides a method for testing a factor for cardiogenicity which comprises differentiating human embryonic stem (hES) cells to cardiomyocytes in the presence and absence of the factor wherein the human embryonic stem (hES) cells are cultured under a serum free condition comprising co-culture in the presence of END-2 cells or serum-free extracellular medium therefrom, and measuring the differentiation in the presence and absence of the factor. This invention also provides a method for identifying a cardiogenic factor, which comprises differentiating human embryonic stem (hES) cells to cardiomyocytes in the presence or absence of the factor wherein the human embryonic stem (hES) cells are cultured under a serum free condition comprising co-culture in the presence of END-2 cells or serum-free extracellular medium therefrom, and identifying the factor that affects the differentiation of human embryonic stem (hES) cells to cardiomyocytes in the presence or absence of the factor. | 2015-12-17 |
20150361400 | COMPOSITIONS AND METHODS FOR MAINTAINING AND IMPROVING PANCREATIC ISLET CELL FUNCTION AND STABILITY - Compositions and methods for production of beta islet cells exhibiting superior endocrine like functions are disclosed. | 2015-12-17 |
20150361401 | INDUCED PLURIPOTENT STEM CELL MODEL FOR FABRY DISEASE AND USE THEREOF - The present invention relates to an induced pluripotent stem cell model of Fabry disease, a preparation method thereof, and a use of the same for the study of Fabry disease development and for the screening of a therapeutic agent for the disease. Particularly, Fabry disease derived induced pluripotent stem cells (iPSCs), embryoid body (EB), and vascular cells were developed and differentiated from fibroblasts originated from Fabry disease patient, wherein the Fabry disease originated iPSCs displayed significantly reduced expression and activity of GLA protein therein, compared with the normal cells, resulting in the accumulation of globotriaosylceramide (Gb3, CD77). Also, the differentiation of vascular cells was induced from the Fabry disease originated iPSCs, and as a result the iPSCs were successfully differentiated into vascular endothelial cells and vascular smooth muscle cells with significantly expressing the marker protein. When the vascular endothelial cells and vascular smooth muscle cells were treated with Fabrazyme, the accumulation of Gb3 was significantly reduced, suggesting that the said cell model can be effectively used for the analysis/study of Fabry disease outbreak mechanism and for the screening of a therapeutic agent for the disease. | 2015-12-17 |
20150361402 | VIRAL NANOPARTICLE MULTIMERS - Virus particle multimers and methods of making and using such virus particle multimer are described. Virus particle multimers are constructed by preparing a plurality of asymmetrically functionalized virus particles bearing one or more functional groups and contacting the asymmetrically functionalized virus particles with a first linker molecule that reacts with the functional groups to form a virus particle multimer that includes a plurality of asymmetrically functionalized virus particles connected by the linker molecule. The asymmetrically functionalized virus particles are typically prepared by attaching the virus particles to a support surface to allow asymmetrical functionalization to be introduced. | 2015-12-17 |
20150361403 | IMPROVED BACULOVIRAL EXPRESSION SYSTEM AND METHODS OF PRODUCING THE SAME - The present invention is based on the discovery that large parts of the genome of nucleopolyhedtovirus (NPV)-alpha baculovirus clade Ia viruses can be deleted with out deleterious effect on the usability of the virus comprising such genome in the infection of cells in cell culture. Accordingly, the present invention provides NPY-alpha baculovirus clade Ia genome which is reduced in size in comparison to the respective native NPV-alpha baculovirus clade Ia genome, such genomes comprising heterologous nucleotides, viruses comprising either of these genomes, cells infected with such viruses and methods for producing such viruses and cells. | 2015-12-17 |
20150361404 | METHOD FOR PRODUCING POLYUNSATURATED FATTY ACIDS IN TRANSGENIC PLANTS - The present invention relates to a process for the production of polyunsaturated fatty acids in the seed of transgenic plants by introducing, into the organism, nucleic acids which encode polypeptides with a ω3-desaturase, Δ12-desaturase, Δ6-desaturase, Δ6-elongase, Δ5-desaturase, Δ5-elongase and/or Δ4-desaturase activity. The invention furthermore relates to recombinant nucleic acid molecules comprising the nucleic acid sequences which encode the aforementioned polypeptides, either jointly or individually, and transgenic plants which comprise the aforementioned recombinant nucleic acid molecules. Furthermore, the invention relates to the generation of a transgenic plant and to oils, lipids and/or fatty acids with an elevated content of polyunsaturated fatty acids, in particular arachidonic acid, eicosapentaenoic acid and/or docosahexaenoic acid, as the result of the expression of the elongases and desaturases used in the process according to the invention. | 2015-12-17 |
20150361405 | HIGH LEVEL EXPRESSION OF RECOMBINANT TOXIN PROTEINS - The present invention relates to the field of recombinant toxin protein production in bacterial hosts. In particular, the present invention relates to production processes for obtaining high levels of a recombinant CRM197, Diphtheria Toxin, Pertussis Toxin, Tetanus Toxoid Fragment C, Cholera Toxin B, Cholera holotoxin, and | 2015-12-17 |
20150361406 | Method of Producing Dicer - The present disclosure provides a method for producing a Dicer polypeptide in a prokaryotic host cell. The present disclosure further provides a purified Dicer complex. The present disclosure further provides kits for producing a Dicer polypeptide in a prokaryotic host cell. | 2015-12-17 |
20150361407 | ENZYME PRODUCTION COMPOSITIONS AND METHODS - The present invention provides compositions and methods for the production of enzymes. Interest has arisen in fermentation of carbohydrate-rich biomass to provide alternatives to petrochemical sources for fuels and organic chemical precursors. “First generation” bioethanol production from carbohydrate sources (e.g., sugar cane, corn, wheat, etc.) have proven to be marginally economically viable on a production scale. | 2015-12-17 |
20150361408 | CARBOHYDRATE DEGRADING POLYPEPTIDE AND USES THEREOF - The invention relates to a polypeptide having hemicellulase activity. The invention features the full length coding sequence of the novel gene as well as the amino acid sequence of the full-length functional protein and functional equivalents of the gene or the amino acid sequence. The invention also relates to methods for using the polypeptide in industrial processes. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins. | 2015-12-17 |
20150361409 | ENOLASE 1 (ENO1) COMPOSITIONS AND USES THEREOF - The invention provides compositions comprising Eno1 for delivery to a muscle. Further, the invention provides a method for normalizing blood glucose in a subject with elevated blood glucose, comprising administering to the subject enolase 1 (Eno1), thereby normalizing blood glucose in the subject. The invention also provides methods of treating one or more conditions including impaired glucose tolerance, insulin resistance, pre-diabetes, and diabetes, especially type 2 diabetes in a subject, comprising administering to the subject enolase 1 (Eno1), thereby treating the condition in the subject. In certain methods of the invention, the Eno1 is delivered to muscle. | 2015-12-17 |
20150361410 | INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF PHENYLALANYL-ALPHA-TRNA SYNTHETASES - Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications. | 2015-12-17 |
20150361411 | INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF VALYL-TRNA SYNTHETASES - Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications. | 2015-12-17 |
20150361412 | INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF GLUTAMINYL-TRNA SYNTHETASES - Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications. | 2015-12-17 |
20150361413 | INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF P38 MULTI-TRNA SYNTHETASE COMPLEX - Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications. | 2015-12-17 |
20150361414 | Microfluidic Droplet Encapsulation - Microfluidic devices and methods for the encapsulation of particles within liquid droplets are disclosed. The new methods and devices form 1-100 picoliter-size monodisperse droplets containing the particles, such as single cells, encapsulated in individual liquid droplets. The particles can be encapsulated in droplets of a fluid by passing a fluid containing the particles through a high aspect-ratio microchannel to order the particles in the fluid, followed by forming the fluid into droplets. The resulting fraction of the liquid droplets with a single particle (e.g., a cell) is higher than the corresponding fraction of single-particle liquid droplets predicted by Poisson statistics. | 2015-12-17 |
20150361415 | ROBUST, EASY TO USE IMMOBILIZED ENZYME REACTORS - The disclosure provides an innovative immobilized enzyme reactor working system that includes improved reactor formats, heating element, optimum buffers, filtration apparatus and collection componentry for easy to use sample preparation. The system provides enhanced recovery, improved reproducibility and parallel processing capabilities capable of quantitatively processing hundreds of difficult to digest samples simultaneously in a shortened period of time. | 2015-12-17 |
20150361416 | METHOD OF PRODUCING NANOBIOCATALYSTS - A method of producing nanobiocatalysts includes: suspending a support material in a liquid medium; functionalizing a surface of the support material by mixing the suspended support material with a functionalizer for a first predefined time at a first predefined temperature, wherein a first broth results; applying a protein directly in the first broth after the first predefined time; mixing the protein with the first broth and incubating the protein for a second predefined time at a second predefined temperature, wherein a second broth results; immobilizing the incubated protein onto the functionalized surface of the support material, wherein a third broth results; filtering the third broth; and gathering a retentate of the filtering. By directly processing the first and second broths allows for providing a continuous process and production of the nanobiocatalysts, which can be optimized regarding time, water, chemical and energy consumption. Also, problems related to thixotrophy can be minimized. | 2015-12-17 |
20150361417 | ASSAY FOR DETECTION OF JC VIRUS DNA - In one aspect, the disclosure provides methods for isolating nucleic acid from a Cerebrospinal Fluid (CSF) sample. In one aspect, the disclosure provides methods for determining the amount of JC virus DNA in a sample. | 2015-12-17 |
20150361418 | Systems and Methods for Substrate Enrichment - A method of separating bead substrates includes applying an emulsion to an emulsion-breaking solution. A dispersed phase of the emulsion includes an unbound polynucleotide, a first set of bead substrates and a second set of bead substrates. The unbound polynucleotide includes a segment complementary to a coupling oligonucleotide. The first set of bead substrates includes the coupling oligonucleotide extended to include a segment complementary to a portion of the unbound polynucleotide. The second set of bead substrates includes the coupling oligonucleotide. The emulsion-breaking solution includes an interference probe having a sequence similar to the coupling oligonucleotide or complementary to the coupling oligonucleotide. The method further includes binding beads of the first set of bead substrates to separation substrates and separating unbound beads of the second set of bead substrates from the beads of the first set of bead substrates bound to the separation substrates. | 2015-12-17 |
20150361419 | MICROFLUIDIC CHIP FOR EXTRACTING NUCLEIC ACIDS, DEVICE FOR EXTRACTING NUCLEIC ACIDS COMPRISING SAME, AND METHOD FOR EXTRACTING NUCLEIC ACIDS USING SAME - The present invention relates to a microfluidic chip for extracting nucleic acids, a nucleic acid extraction device having the same, and a nucleic acid extraction method using the same that can provide micro-miniaturization and ultra high speed, while maintaining and/or improving reliable nucleic acid extraction efficiencies, unlike the existing nucleic acid extraction device and method. | 2015-12-17 |
20150361420 | Methods for Screening Proteins Using DNA Encoded Chemical Libraries as Templates for Enzyme Catalysis - Disclosed are methods, compositions and devices for screening a protein library for proteins having a desired activity, such as capable of catalyzing the formation of a bond between two reactants. In an exemplary embodiments, a plurality of proteins are expressed in vitro from a plurality of nucleic acids, the plurality of proteins are exposed with two single stranded oligonucleotides having complementary sequences, each oligonucleotide having a reactant and a fluorophore, the fluorescence of the protein-reactant-oligonucleotide-fluorophore complexes is detected and the complexes showing detectable fluorescence energy transfer are isolated, thereby isolating proteins having the desired enzymatic activity. | 2015-12-17 |
20150361421 | COMPOSITIONS AND METHODS FOR GROWTH FACTOR MODULATION - Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-β superfamily of proteins. | 2015-12-17 |
20150361422 | HIGH THROUGHPUT GENE ASSEMBLY IN DROPLETS - Provided herein, among other things, is a method comprising: (a) obtaining a mixture of multiple sets of oligonucleotides, wherein the oligonucleotides within each set each comprise a terminal indexer sequence can be assembled to produce a synthon; and (b) hybridizing the oligonucleotide mixture to an array, thereby spatially-separating the different sets of oligonucleotides from one another. Other embodiments are also provided. | 2015-12-17 |
20150361423 | HIGH THROUGHPUT GENE ASSEMBLY IN DROPLETS - Provided herein is a method comprising: (a) obtaining a mixture of multiple sets of oligonucleotides, wherein the oligonucleotides within each set each comprise a terminal indexer sequence and can be assembled to produce a synthon; and (b) hybridizing the oligonucleotide mixture to an array, thereby spatially-separating the different sets of oligonucleotides from one another. In some embodiments the method may comprise (c) contacting the array with a solution, thereby producing, for each feature bound by the oligonucleotides, a discrete droplet comprising the feature and, optionally, placing an immiscible liquid over the droplets, thereby producing, for each feature bound by the oligonucleotides, a discrete reaction chamber defined by a droplet. The method may further comprise incubating the array under conditions by which a synthon is assembled in each of the reaction chambers. Other embodiments are also provided. | 2015-12-17 |
20150361424 | INDUCTION OF EXON SKIPPING IN EUKARYOTIC CELLS - The present invention provides a method for at least in part decreasing the production of an aberrant protein in a cell, the cell comprising pre-mRNA comprising exons coding for the protein, by inducing so-call exon skipping in the cell. Exon-skipping results in mature mRNA that does not contain the skipped exon, which leads to an altered product of the exon codes for amino acids. Exon skipping is performed by providing a cell with an agent capable of specifically inhibiting an exon inclusion signal, for instance, an exon recognition sequence, of the exon. The exon inclusion signal can be interfered with by a nucleic acid comprising complementarity to a part of the exon. The nucleic acid, which is also herewith provided, can be used for the preparation of a medicament, for instance, for the treatment of an inherited disease. | 2015-12-17 |
20150361425 | ANTISENSE ANTIBACTERIAL COMPOUNDS AND METHODS - Provided are antisense morpholino oligomers targeted against bacterial virulence factors such as genes that contribute to antibiotic resistance or biofilm formation, or genes associated with fatty acid biosynthesis, and related compositions and methods of using the oligomers and compositions, for instance, in the treatment of an infected mammalian subject. | 2015-12-17 |
20150361426 | ROTATIONALLY SEQUESTERED TRANSLATORS - Provided are nucleic acid translators capable of carrying out logic operations with improved efficiency, maximized output and reduced off-target effects, in particular in a biological system. Methods of using these translators to transduce signal are also provided. | 2015-12-17 |
20150361427 | Compositions and Methods for Inhibiting Gene Expression of Alpha-1 AntiTrypsin - The invention relates to a RNA interference triggers for inhibiting the expression of an AAT gene through the mechanism of RNA interference. The invention also relates to a pharmaceutical composition comprising the AAT RNAi trigger together with an excipient capable of improving delivery of the RNAi trigger to a liver cell in vivo. Delivery of the AAT RNAi trigger to liver cells in vivo provides for inhibition of AAT gene expression and treatment of alpha 1-antitrypsin deficiency and associated diseases. | 2015-12-17 |
20150361428 | EXON SKIPPING COMPOSITIONS FOR TREATING MUSCULAR DYSTROPHY - Antisense molecules capable of binding to a selected target site in the human dystrophin gene to induce exon 53 skipping are described. | 2015-12-17 |
20150361429 | METHODS AND COMPOSITIONS FOR TARGETING IMMUNOGLOBULINS - The present invention relates to compositions and methods for targeting immunoglobulins and immunoglobulin-producing plasma cells. In particular, the present invention provides nucleic acid based compounds for targeting immunoglobulins for research, screening, and therapeutic applications. | 2015-12-17 |
20150361430 | METHODS FOR TREATING EYE DISORDERS - The present invention relates to compositions and methods for inhibiting loss of a retinal ganglion cell in a subject, comprising non-invasively applying to the surface of the eye of the subject an ophthalmic composition comprising a therapeutically effective amount of at least one siRNA which down regulates expression of a target gene associated with loss of the retinal ganglion cell, thereby inhibiting loss of the retinal ganglion cell in the subject. The methods of the invention also relate to the use of chemically modified siRNA compounds possessing structural motifs which down-regulate the expression of human genes expressed in retinal tissue in the mammalian eye. | 2015-12-17 |
20150361431 | METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES - The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays. | 2015-12-17 |
20150361432 | MODIFIED SMALL INTERFERING RNA MOLECULES AND METHODS OF USE - The present invention provides double-stranded RNA molecules that mediate RNA interference in target cells, preferably hepatic cells. The invention also provides double-stranded RNA (dsRNA) molecules that are modified to be resistant to nuclease degradation, which inactivates a virus, and more specifically, hepatitis C virus (HCV). The invention also provides a method of using these modified RNA molecules to inactivate virus in mammalian cells and a method of making modified small interfering RNAs (siRNAs) using human Dicer. The invention provides modified RNA molecules that are modified to include a dsRNA or siRNA wherein one or more of the pyrimidines in the RNA molecule are modified to include 2′-Fluorine. The invention also provides dsRNA or siRNA in which all pyrimidines are modified to include a 2′-Fluorine. The invention provides that the 2′-Fluorine dsRNA or siRNA molecule is further modified to include a two base deoxynucleotide “TT” sequence at the 3′ end of the molecule. | 2015-12-17 |
20150361433 | INHIBITORS OF MIRNAS 221 AND 222 FOR ANTI-TUMOR ACTIVITY IN MULTIPLE MYELOMA - Inhibitors of miRNAs 221 and 222, and their use as medicaments in the treatment of multiple myeloma. The inhibitors inhibit miRNAs 221 and 222 of the type of LNA-miRNAs and have the formula +C*A*G*+A*+C*A*+A*T*+G*T*+A*+G*C, and formula C*+A*+G*+A*T*+G*T*+A*+G*C wherein letters with symbol “+” indicate the positions of LNA and symbol “*” indicates phosphorothioate bonds. | 2015-12-17 |
20150361434 | NOVEL LOW MOLECULAR WEIGHT CYCLIC AMINE CONTAINING CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY - The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids comprising at least one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA. | 2015-12-17 |
20150361435 | IDENTIFICATION OF INHIBITORS OF A BACTERIAL STRESS RESPONSE - A system, a composition, a method and a kit for identifying anti-bacterial agents are provided. The invention described herein is useful in identifying inhibitors of any bacterial stress response. Moreover, the invention can be applied to any sRNA and its target, any transcription factor and its target, and any transcription factor/sRNA pair (i.e., a transcription factor that regulates a sRNA). In particular, the present invention provides a system, a composition, a method and a kit for the identification of cyclic peptides that block the σ | 2015-12-17 |
20150361436 | GENETICALLY MODIFIED BACTERIA AND METHODS FOR GENETIC MODIFICATION OF BACTERIA - Microbes can be genetically modified to express biomolecules that are beneficial to mammals and/or to reduce, or eliminate, expression of harmful virulence factors. The growth and viability of such genetically modified microbes can optionally be controlled by inducible promoters that regulate the expression of proteins that are essential to their growth and survival. Compositions comprising such genetically modified microbes as well as methods of making and using the same are disclosed herein. | 2015-12-17 |
20150361437 | RECOMBINANT YEAST TRANSFORMANT AND PROCESS FOR PREPARING IMMUNOGLOBULIN FC FRAGMENT EMPLOYING THE SAME - The present invention relates to a transformant prepared by introducing an expression vector comprising a polynucleotide encoding for a human immunoglobulin Fc fragment into | 2015-12-17 |
20150361438 | YEAST STRAINS FOR PROTEIN PRODUCTION - Method and system for expression systems, based on ade1 and ade2 auxotrophic strains of yeast and fungi, including | 2015-12-17 |
20150361439 | Expression of Human Interferon in Transgenic Chloroplasts - A plastid transformation vector for a stably transforming a plastid genome is provided. The vector includes, as operably-linked components, a first flanking sequence, a DNA sequence coding for a therapeutic human IFN, which is capable of expression in the plastid and a second flanking sequence. The invention also provides isolated and purified IFN, wherein the IFN is configured in a monomeric or multimeric form and is a structural equivalent to orally administered human IFN. Also provided are methods for variable-expressing biopharmaceutical proteins in plants suitable for mammal consumption. The method includes integrating a plastid transformation vector into a plastid genome of a plant cell; growing the plant cell to express a biopharmaceutical protein, such as therapeutic human interferon IFN. Also disclosed are plants transformed with the aforementioned vectors, and the progeny thereof. Also, disclosed is the IFN, which is IFNα2b. | 2015-12-17 |
20150361440 | REGULATORY NUCLEIC ACID MOLECULES FOR ENHANCING SEED-SPECIFIC AND/OR SEED-PREFERENTIAL GENE EXPRESSION IN PLANTS - The present invention is in the field of plant molecular biology and provides methods for production of high expressing seed-specific and/or seed-preferential promoters and the production of plants with enhanced seed-specific and/or seed-preferential expression of nucleic acids wherein nucleic acid expression enhancing nucleic acids (NEENAs) are functionally linked to the promoters and/or introduced into plants. | 2015-12-17 |
20150361441 | Plants Having Enhanced Yield-Related Traits And A Method For Making The Same - The present invention concerns a method for enhancing yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a CLC-like (Chloride Channel-like) polypeptide, an OsBURP-like (BURP-domain containing protein) polypeptide, an AP2/ERF polypeptide, or a protein fusion comprising a TPS (trehalose-6-phosphate synthase) and a TPP (trehalose-6-phosphate phosphatase) polypeptide, or modulating one or more nucleic acids encoding a TPS and a TPP enzyme, whether comprised in the same or in separate molecules. The present invention also concerns plants having modulated expression of a nucleic acid encoding a CLC-like polypeptide, an OsBURP-like polypeptide, an AP2/ERF polypeptide, or a TPP polypeptide, which plants have enhanced yield-related traits relative to control plants. Also provided are unknown TPS-encoding and TPP-encoding nucleic acids, and constructs comprising the same, and constructs a CLC-like, OsBURP-like, or AP2/ERF coding nucleic acid useful in performing the methods of the invention. | 2015-12-17 |
20150361442 | USE OF DIMERIZATION DOMAIN COMPONENT STACKS TO MODULATE PLANT ARCHITECTURE - This invention provides means for altering the harvest index of crop plants by modulating the expression of transgenic genes using dimerization domain and component stacks, thereby modulating plant architecture. The transgene/dimerization domain stacks are provided in a single transformation vector unit and are used to modulate plant growth, yield, and harvest index in plants. | 2015-12-17 |
20150361443 | FUNGAL RESISTANT PLANTS EXPRESSING HCP6 - The present invention relates to a method of increasing resistance against fungal pathogens of the family Phacosporaceae in plants and/or plant cells. This is achieved by increasing the expression of an HCP6 protein or fragment thereof in a plant, plant part and/or plant cell in comparison to wild type plants, wild type plant parts and/or wild type plant cells. Furthermore, the invention relates to transgenic plants, plant parts, and/or plant cells having an increased resistance against fungal pathogens, in particular, pathogens of the family Phacopsoraceae, and to recombinant expression vectors comprising a sequence that is identical or homologous to a sequence encoding an HCP6 protein. | 2015-12-17 |
20150361444 | METHODS AND COMPOSITIONS FOR SELECTING SOYBEAN PLANTS RESISTANT TO PHYTOPHTHORA ROOT ROT - The present invention relates to the field of plant breeding and disease resistance. More specifically, the invention includes a method for breeding soybean plants containing quantitative trail loci (QTL) for resistance the | 2015-12-17 |
20150361445 | A METHOD FOR THE CONTROL OF NEMATODES IN PLANTS - The present invention relates to the field of double-stranded RNA (ds RNA) mediated gene silencing of root knot nematodes. The invention particularly provides an effective method for reducing the number of reproducing population and the number of progenies per individual of the root knot nematodes. The present invention also relates to host delivered dsRNA for controlling infection of root knot nematodes. | 2015-12-17 |
20150361446 | MAIZE EVENT DP-033121-3 AND METHODS FOR DETECTION THEREOF - The disclosure provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DP-033121-3 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided. | 2015-12-17 |
20150361447 | MAIZE EVENT DP-032218-9 AND METHODS FOR DETECTION THEREOF - The disclosure provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DP-032218-9 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided. | 2015-12-17 |
20150361448 | PLANTS AND SEEDS OF CANOLA VARIETY SCV356872 - In an embodiment, the invention relates to the seeds, plants, and plant parts of canola variety SCV356872 and to methods for producing a canola plant produced by crossing canola variety SCV356872 with itself or with another canola variety. The invention also relates to methods for producing a canola plant containing in its genetic material one or more transgenes and to the transgenic canola plants and plant parts produced by those methods. This invention also relates to canola varieties or breeding lines and plant parts derived from canola variety SCV356872, to methods for producing other canola varieties, lines or plant parts derived from canola variety SCV356872 and to the canola plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid canola seeds, plants and plant parts produced by crossing the variety SCV356872 with another canola variety. | 2015-12-17 |
20150361449 | NOVEL REAGENT FOR GENE-DRUG THERAPEUTICS - The present invention relates to a composition for transfecting a cell with a genetic material comprising a first agent capable of directing the genetic material away from the acidic compartments in the cell and a second agent capable of stabilizing the microtubule or a network thereof. The invention also relates to the use of the composition in the manufacture of a medicament for treating a disease, a method for delivering a genetic material into a cell and a kit. | 2015-12-17 |
20150361450 | VECTOR FOR THERAPY OF MITOCHONDRIAL DISEASE - The present invention relates to mitochondrial RNA vectors with which a nucleic acid of interest may be imported into human mitochondria, in particular to suppress negative effects of mutations in mtDNA by affecting the level of heteroplasmy. | 2015-12-17 |
20150361451 | Enhanced Transgene Expression and Processing - Disclosed are constructs and methods for expressing DNAs of interest in particular in non-primate eukaryotic host cells that display advantages with regard quantity and quality of expression including high stability of expression and, if appropriate, transport of the expression product out of the cell. | 2015-12-17 |
20150361452 | A Helper-Dependent Adenoviral Gene Therapy Delivery and Expression System - The present invention relates to gene therapy delivery and expression systems comprising at least one helper-dependent adenoviral vector containing a nucleic acid sequence encoding for proteoglycan 4 (PRG4) or a biologically active fragment thereof. The invention further relates to a pharmaceutical composition comprising a therapeutically effective amount of at least one helper-dependent adenoviral vector containing said nucleic acid sequence encoding for proteoglycan 4 (PRG4), or a homolog thereof from any other species, or a biologically active fragment thereof. The invention also relates to the use of the novel gene therapy delivery and expression system according to the invention for use in the prevention and/or treatment of camptodactyly-arthropathy-coxa vara-pericarditis (CACP), or a musculoskeletal disorder such as a joint disorder or joint disease. | 2015-12-17 |
20150361453 | PLATELETS TRANSFECTED BY EXOGENOUS GENETIC MATERIAL AND PLATELET MICROPARTICLES OBTAINED BY SAID TRANSFECTED PLATELETS, METHOD FOR THE PREPARATION AND USES THEREOF - Platelets transfected with exogenous genetic material and microparticles deriving from said transfected platelets are discussed. The platelets have a high percentage of transfection and are able to transport and to transfect acceptor cells with genetic material and then are used for example in gene and cell therapy. The invention further concerns a method for the preparation of mature platelets transfected with exogenous genetic material and microparticles deriving from said transfected platelets and microparticles deriving from said transfected mature platelets which permits to obtain high percentages of transfection. | 2015-12-17 |
20150361454 | ACYL-ACP REDUCTASE WITH IMPROVED PROPERTIES - The disclosure relates to acyl-ACP reductase (AAR) enzyme variants that result in improved fatty aldehyde and fatty alcohol production when expressed in recombinant host cells. The disclosure further relates to methods of making and using such AAR variants for the production of fatty alcohol compositions having particular characteristics. | 2015-12-17 |
20150361455 | METABOLICALLY ENGINEERED CELLS FOR THE PRODUCTION OF RESVERATROL OR AN OLIGOMERIC OR GLYCOSIDICALLY-BOUND DERIVATIVE THEREOF - A recombinant micro-organism producing resveratrol by a pathway in which phenylalanine ammonia lyase (PAL) produces trans-cinnamic acid from phenylalanine, cinnamate 4-hydroxylase (C4H) produces 4-coumaric acid from said trans-cinnamic acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA, or in which L-phenylalanine- or tyrosine-ammonia lyase (PAL/TAL) produces 4-coumaric acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA. The micro-organism may be a yeast, fungus or bacterium including | 2015-12-17 |
20150361456 | Enzymatic Hydroxylation of Aliphatic Hydrocarbon - The invention relates to enzymatic methods for hydroxylation in position 2 or 3 of substituted or unsubstituted, linear or branched aliphatic hydrocarbons. | 2015-12-17 |
20150361457 | PROCESSING AND TRANSFORMING BIOMASS - Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful intermediates and products, such as energy, fuels, foods or materials. The saccharified biomass is fermented in two steps to form two separate products. The second product can be a carboxylic acid which is reacted with an alcohol to form an ester. The alcohol used for the esterification may be obtained from the biomass. The ester is hydrogenated to alcohols with catalysts. | 2015-12-17 |
20150361458 | METHODS, REAGENTS AND CELLS FOR BIOSYNTHESIZING COMPOUND - This document describes biochemical pathways for producing 2(E)-heptenedioyl-CoA methyl ester from precursors such as 2-oxo-glutarate, acetyl-CoA, or succinyl-CoA using one or more of a fatty acid O-methyltransferase, a thioesterase, a CoA-transferase, a CoA ligase, as well as recombinant hosts expressing one or more of such enzymes. 2(E)-heptenedioyl-CoA methyl ester can be enzymatically converted to pimeloyl-CoA using a trans-2-enoyl-CoA reductase, and a methylesterase. Pimeloyl-CoA can be enzymatically converted to pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol. | 2015-12-17 |
20150361459 | METHODS, REAGENTS AND CELLS FOR BIOSYNTHESIZING COMPOUNDS - This document describes biochemical pathways for producing glutaric acid, 5-aminopentanoic acid, 5-hydroxypentanoic acid, cadaverine or 1,5-pentanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C5 backbone substrate such as malonyl-CoA or malonyl-[acp]. | 2015-12-17 |
20150361460 | METHODS, REAGENTS AND CELLS FOR BIOSYNTHESIZING COMPOUNDS - This document describes biochemical pathways for producing 2,4-pentadienoyl-CoA by forming one or two terminal functional groups, comprised of carboxyl or hydroxyl group, in a C5 backbone substrate such as glutaryl-CoA, glutaryl-[acp] or glutarate methyl ester. 2,4-pentadienoyl-CoA can be enzymatically converted to 1,3-butadiene. | 2015-12-17 |
20150361461 | METHOD FOR PRODUCING DHA THROUGH SOLID CULTURE AND LIQUID FERMENTATION OF SCHIZOCHYTRIUM - The invention relates to a method for fermentation production of DHA, in particular a method for producing DHA through solid culture and liquid fermentation of | 2015-12-17 |
20150361462 | METHODS OF PRODUCING 6-CARBON CHEMICALS USING 2,6-DIAMINOPIMELATE AS PRECURSOR TO 2-AMINOPIMELATE - This document describes biochemical pathways for producing 2-aminopimelate from 2,6-diaminopimelate, and methods for converting 2-aminopimelate to one or more of adipic acid, adipate semialdehyde, caprolactam, 6-aminohexanoic acid, 6-hexanoic acid, hexamethylenediamine, or 1,6-hexanediol by decarboxylating 2-aminopimelate into a six carbon chain aliphatic backbone and enzymatically forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in the backbone. | 2015-12-17 |
20150361463 | METHODS, REAGENTS AND CELLS FOR BIOSYNTHESIZING COMPOUNDS - This document describes biochemical pathways for producing 2,3-dehydroadipyl-CoA methyl ester from precursors such as 2-oxoglutarate using one or more of a fatty acid O-methyltransferase, a thioesterase, a CoA-transferase and a CoA ligase, as well as recombinant hosts expressing one or more of such enzymes. 2,3-dehydroadipyl-CoA methyl ester can be enzymatically converted to adipyl-CoA using a trans-2-enoyl-CoA reductase, and a methylesterase, which in turn can be enzymatically converted to adipic acid, 6-aminohexanoate, 6-hydroxyhexanoate, caprolactam, hexamethylenediamine, or 1,6-hexanediol. | 2015-12-17 |
20150361464 | METHODS, REAGENTS AND CELLS FOR BIOSYNTHESIZING COMPOUNDS - This document describes biochemical pathways for producing glutaric acid, 5-aminopentanoic acid, 5-hydroxypentanoic acid or 1,5-pentanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C5 backbone substrate such as cadaverine or 5-aminopentanamide. | 2015-12-17 |
20150361465 | METHODS, REAGENTS AND CELLS FOR BIOSYNTHESIZING COMPOUNDS - This document describes biochemical pathways for producing 7-hydroxyheptanoate methyl ester and heptanoic acid heptyl ester using one or more of a fatty acid O-methyltransferase, an alcohol O-acetyltransferase, and a monooxygenase, as well as recombinant hosts expressing one or more of such exogenous enzymes. 7-hydroxyheptanoate methyl esters and heptanoic acid heptyl esters can be enzymatically converted to pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol. | 2015-12-17 |
20150361466 | METHODS, REAGENTS AND CELLS FOR BIOSYNTHESIZING COMPOUNDS - This document describes biochemical pathways for producing 6-hydroxyhexanoate methyl ester and hexanoic acid hexyl ester using one or more of a fatty acid O-methyltransferase, an alcohol O-acetyltransferase and a monooxygenase, as well as recombinant hosts expressing one or more of such enzymes. 6-hydroxyhexanoate methyl esters and hexanoic acid hexyl ester can be enzymatically converted to adipic acid, adipate semialdehyde, 6-aminohexanoate, 6-hydroxyhexanoate, hexamethylenediamine, and 1,6-hexanediol. | 2015-12-17 |
20150361467 | METHODS, REAGENTS AND CELLS FOR BIOSYNTHESIZING COMPOUNDS - This document describes biochemical pathways for producing 5-hydroxypentanoate methyl ester and pentanoic acid pentyl ester using one or more of a fatty acid O-methyltransferase, an alcohol O-acetyltransferase, and a monooxygenase, as well as recombinant hosts expressing one or more of such exogenous enzymes. 5-hydroxypentanoate methyl esters and pentanoic acid pentyl esters can be enzymatically converted to glutaric acid, 5-aminopentanoate, 5-hydroxypentanoate, cadaverine, or 1,5-pentanediol. | 2015-12-17 |
20150361468 | METHODS, REAGENTS AND CELLS FOR BIOSYNTHESIZING COMPOUNDS - This document describes biochemical pathways for producing glutaric acid, 5-aminopentanoic acid, 5-hydroxypentanoic acid, cadaverine or 1,5-pentanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C5 backbone substrate such as 2-oxoglutarate. | 2015-12-17 |