50th week of 2021 patent applcation highlights part 25 |
Patent application number | Title | Published |
20210388413 | METHOD FOR THREE-DIMENSIONAL NUCLEIC ACID IMAGING DIAGNOSIS OF TISSUE BY USING ISOTHERMAL NUCLEIC ACID AMPLIFICATION - The present invention relates to a method for three-dimensional nucleic acid imaging diagnosis of a tissue by using isothermal nucleic acid amplification. The method for three-dimensional nucleic acid imaging diagnosis of tissue according to the present invention can allow a specific molecular biomarker to be clearly seen in tissue through clearing of the tissue, enhance diagnostic accuracy by three-dimensionally reconstituting the tissue since all of the inside of the tissue is visualized, and facilitate three-dimensional imaging of a molecular biomarker such as DNA or RNA containing genetic information in the human body through isothermal nucleic acid amplification in tissue, and thus this method can be effectively used in diagnosis of various diseases including cancer. | 2021-12-16 |
20210388414 | OPTIMIZATION OF IN VITRO ISOLATION OF NUCLEIC ACIDS USING SITE-SPECIFIC NUCLEASES - The present invention relates to a method of preparing a nucleic acid molecule comprising a target region for isolation from a sample, said method comprising the steps of contacting a population of nucleic acid molecules with a first Class 2 Type V Cas protein-gRNA complex, wherein the gRNA comprises a guide segment that is complementary to a first sequence within a nucleic acid Q molecule, said first sequence being located adjacent to said target region, thereby forming a Class 2 Type V Cas protein-gRNA-nucleic acid complex, and a protector molecule, contacting the population of nucleic acid molecules with at least one enzyme having exonuclease activity, recovering said nucleic acid molecule comprising the target region from the Class 2 Type V Cas protein-gRNA-nucleic acid complex formed in step a), and contacting the nucleic acid molecule of step c) with a processive polymerase, preferably a mesophilic or thermophilic polymerase, even more preferably a T4 DNA polymerase. | 2021-12-16 |
20210388415 | METHODS AND KITS FOR DEPLETION AND ENRICHMENT OF NUCLEIC ACID SEQUENCES - Kits and methods for enriching target nucleic acid sequences, such as nucleic acid molecules including the target nucleic acid sequence, and kits and methods for depleting target nucleic acid sequences, such as nucleic acid molecules including the target nucleic acid sequences. In an embodiment, the methods for enriching target nucleic acid sequences include selectively degrading single-stranded sample nucleic acid molecules, such as those that do not include the target nucleic acid sequences. In an embodiment, the methods for depleting target nucleic acid sequences include selectively degrading double-stranded sample nucleic acid molecules, such as those including the target nucleic acid sequence. | 2021-12-16 |
20210388416 | UNIVERSAL METHOD FOR EXTRACTING NUCLEIC ACID MOLECULES FROM A DIVERSE POPULATION OF MICROBES - Disclosed herein are methods of extracting genetic material from a diverse population of one or more types of microbes in a sample. Microbes can be prokaryotes or eukaryotes and may include bacteria, archaea, fungi, protozoa, helminths, parasites, viruses, phages, and others. Extraction may be from a single sample and subsequent identification may be through a molecular method such as qPCR, PCR, RFLP, SSCP, allele specific PCR, targeted sequencing, pull down sequencing, whole shotgun sequencing, or other methods. Also provided are methods that include extracting nucleic acid molecules from a variety of organisms such as fungi (i.e., | 2021-12-16 |
20210388417 | METHOD FOR REVERSIBLY PROTECTING AND SEPARATING DNA - The present disclosure provides a method for reversibly protecting and separation DNA, comprising phosphorylating the 5′-terminal of a target DNA molecule, modifying the 5′-terminal by adenylation; adding adenosine DNA-sensitive exonuclease to samples obtained after termination of the reaction to digest the template; finally, the obtained adenylated modified DNA, that is, the obtained target DNA is separated, and subjected to technical analysis such as sequencing and identification, and the 5′end of the obtained sequence is the site of adenylation modification. The method provided by the present disclosure fills the gap that the prior art cannot accurately locate the break site on genomic DNA, can realize the quantitative and positioning analysis of the break site on DNA samples of different lengths and different sources, and is simple to use and easy to operate. And there are no special requirements for samples, high accuracy, low detection background influence, and high resolution. | 2021-12-16 |
20210388418 | Method for Quantifying Molecular Activity in Cancer Cells of a Human Tumour - Disclosed herein is a method for predicting expression profiles of cancerous and non-cancerous cells respectively based on multiple sets of expression profiles, wherein each set of the multiple sets of expression profiles is obtained from tumour-derived samples comprising a mixture of cancerous and non-cancerous cells of one tumour type. | 2021-12-16 |
20210388419 | METHOD AND KIT FOR CHARACTERIZING MICROORGANISMS - The present disclosure provides methods of characterizing one or more microorganisms and kits for characterizing at least one microorganism. Exemplary methods include preparing an amplicon library, sequencing a characteristic gene sequence to obtain a gene sequence, and characterizing the one or more microorganisms based on the gene sequence using a computer-based genomic analysis of the gene sequence. Exemplary kits include at least one forward primer including an adapter sequence and a priming sequence, for a target sequence, and at least one reverse primer. | 2021-12-16 |
20210388420 | METHOD FOR DETECTING A PLURALITY OF SHORT-CHAIN NUCLEIC ACID IN SAMPLE, COMBINATORIAL ANALYSIS KIT, ANALYSIS KIT SUPPLY MANAGEMENT METHOD - According to one embodiment, a detection method is a method for detecting a plurality of target nucleic acids in a sample. The method includes (a) preparing a chain-elongation nucleic acid set group, a primer set, and a probe immobilized substrate, (b) obtaining the target nucleic acid and a long-chain nucleic acid group containing a first sub-chain-elongation nucleic acid and a second sub-chain-elongation nucleic acid, (c) obtaining an amplification product group by maintaining the long-chain nucleic acid group and the primer set under amplification conditions, (d) detecting presence/absence and/or an amount of hybridization, and (e) detecting the plurality of target nucleic acids. | 2021-12-16 |
20210388421 | METHOD FOR DETECTION OF SPECIFIC NUCLEIC ACIDS - The present invention relates to a method for detecting a target RNA polynucleotide by using a catcher polynucleotide which anneals to at least a portion of the target RNA polynucleotide, and a catalytically-inactive crRNA-guided (CRISPR RNA) RNA-binding protein which binds to the target RNA polynucleotide. Further envisaged is a kit for detecting a specific target RNA polynucleotide comprising inter alia one or more catcher polynucleotides complementary to at least a portion of the target RNA polynucleotide, a mature crRNA molecule which is specific for a target sequence on the target RNA polynucleotide and a catalytically-inactive crRNA-guided RNA-binding protein; as well as the use of these ingredients for the detection of the target RNA polynucleotide. | 2021-12-16 |
20210388422 | Tag-Sequence-Attached Two-Dimensional cDNA Library Device, and Gene Expression Analysis Method and Gene Expression Analysis Apparatus Each Utilizing Same - The present invention relates to a method, a device, and an apparatus for analyzing the expression of a gene in single cells. Specifically, the present invention relates to: a device for gene expression analysis, characterized by including a support, in which a nucleic acid probe having a test nucleic acid capture sequence and a known sequence, and further containing a cell recognition tag sequence which differs depending on the difference in position on the surface of the support or in the vicinity of the surface thereof, and a common primer sequence having a known sequence is two-dimensionally distributed and immobilized on the surface of the support or in the vicinity of the surface thereof; and a method and an apparatus using the device for gene expression analysis. | 2021-12-16 |
20210388423 | NUCLEIC ACID ASSAYS USING CLICK CHEMISTRY BIOCONJUGATION - Provided herein are methods of sequencing comprising click chemistry bioconjugation. In some embodiments, target polynucleotide sequences on the same or different molecules are contacted with and hybridize to probes comprising click functional groups. Probes (e.g., reading probes) hybridizing to adaptor sequences adjacent to different sequences of interest (e.g., barcodes to be sequenced) can be hybridized simultaneously in large pools. In some embodiments, the provided methods achieve multiplexing without requiring separate hybridization of probes (e.g., reading probes) for each sequencing-by-ligation cycle, thereby reducing total hybridization time which is typically a most time-consuming step in in situ technologies. In some aspects, the hybridized probes (e.g., reading probes) are clicked onto detectable probes to analyze a sequence of a target polynucleotide in a sequencing-by-ligation fashion. | 2021-12-16 |
20210388424 | METHODS FOR ANALYZING TARGET NUCLEIC ACIDS AND RELATED COMPOSITIONS - The present disclosure, among other things, provides methods for analyzing a target nucleic acid in a biological sample. In some aspects, the methods involve the use of a set of probe polynucleotides, for example comprising three polynucleotides, for assessing target nucleic acids. In some aspects, the presence, amount and/or sequence of the target nucleic acid is analyzed in situ. In some aspects, the methods involve anchoring or linking a portion of the set of polynucleotides to a scaffold or other nucleic acids. Also provided are polynucleotides, set of polynucleotides, compositions, kits, devices and systems for use in accordance with the methods. | 2021-12-16 |
20210388425 | Nicking and Extension Amplification Reaction for the Exponential Amplification of Nucleic Acids - The invention is in general directed to the rapid exponential amplification of short DNA or RNA sequences at a constant temperature. | 2021-12-16 |
20210388426 | RATIOMETRIC FLUORESCENCE CODING METHOD FOR MULTIPLEX NUCLEIC ACID AMPLIFICATION ASSAYS - Methods for multiplexed detection of a nucleic acid sequence in a sample including the use of a plurality of oligonucleotide target-specific probes (TSPs) configured to bind to a distinct target nucleic acid sequence, where each of the TSPs includes one or more copies of a first fluorescent probe (FP) binding region and one or more copies of a second FP binding region, and where a predetermined ratio of the one or more copies of the first FP binding region to the one or more copies of the second FP binding region is indicative of the distinct target nucleic acid sequence the TSP is configured to bind to. | 2021-12-16 |
20210388427 | LIQUID SAMPLE WORKFLOW FOR NANOPORE SEQUENCING - The present invention relates to a method of characterizing a target DNA polynucleotide using rolling circle amplification (RCA) and a synthetic single guide RNA (sgRNA) to identify and cleave the WT version of the target DNA polynucleotide. Also provided are characterization steps based on the use of a transmembrane pore and a DNA translocase enzyme controlling the movement of the DNA polynucleotide through the transmembrane pore. Further envisaged is a kit comprising one or more oligonucleotides specific for at least a portion of the target DNA polynucleotide, an sgRNA specific for the WT version of the target DNA polynucleotide and an sgRNA-guided nucleic acid-binding protein. | 2021-12-16 |
20210388428 | METHOD AND DEVICE FOR AMPLIFYING AND DETECTING GENE - Provided is a device for amplifying and detecting a gene. The device for amplifying and detecting the gene includes a gene amplification chip comprising channels through which a sample flows and transparent heaters provided on the gene amplification chip. The channels include a first channel, a second channel, and a third channel, and the first to third channels have a triangular loop structure, and the transparent heaters include a first transparent heater, a second transparent heater, and a third transparent heater, which are respectively provided on the first to third channels. | 2021-12-16 |
20210388429 | DIGITAL AMPLIFICATION ASSAYS FOR GENETIC INSTABILITY - Methods and compositions for detecting genetic instability using digital amplification assays. The methods may be performed in a set of isolated volumes and generally may involve competitive hybridization of a competitor and a probe/primer with a normal allele and one or more mutant alleles of a microsatellite locus. The competitor may be configured to compete similarly with, or to outcompete, the primer/probe for hybridization with the normal allele. The primer/probe may be configured to outcompete the competitor for hybridization with various mutant alleles of the locus that alter the length of the repetitive sequence by different amounts. Isolated volumes in which the primer/probe outcompetes the competitor may be enumerated, and represent one or more of the mutant alleles. The methods may enable diagnosing microsatellite instability and treating a subject based on the diagnosis. | 2021-12-16 |
20210388430 | COMPOSITIONS OF TOEHOLD PRIMER DUPLEXES AND METHODS OF USE - Provided herein are primers and primer systems having improved specificity and kinetics over existing primers, and methods of use thereof. | 2021-12-16 |
20210388431 | THERMOKINETICALLY BALANCED ISOTHERMAL AMPLIFICATION OF NUCLEIC ACID SEQUENCES - Provided are methods for isothermal amplification of nucleic acids wherein hybridization of one or both target-amplifying primers to corresponding target sequence strands, primer extension by a DNA polymerase and denaturation of the resulting target sequence amplicons takes place at the same temperature in an isothermal cycling mode, thus amplifying the target nucleic acid sequence. The methods were shown to substantially accelerate conventional PCR. Also provided are kits comprising at least one, preferably at least two target-specific oligonucleotides configured to provide for accelerated isothermal amplification. | 2021-12-16 |
20210388432 | POLYNUCLEOTIDE SYNTHESIS METHOD, KIT AND SYSTEM - The invention relates to new methods for synthesising polynucleotide molecules according to a predefined nucleotide sequence. The invention also relates to methods for the assembly of synthetic polynucleotides following synthesis, as well as systems and kits for performing the synthesis and/or assembly methods. | 2021-12-16 |
20210388433 | Compositions and Methods for Analyzing Modified Nucleotides - A method for identifying any of the presence, location and phasing of modified cytosines (C) in long stretches of nucleic acids is provided. In some embodiments, the method may comprise (a) reacting a first portion of a nucleic acid sample containing at least one C and/or at least one modified C with a DNA glucosyltransferase and a cytidine deaminase to produce a first product and/or reacting a second portion of the sample with a dioxygenase, optionally a DNA glucosyltransferase and a cytidine deaminase to produce a second product and; (b) comparing the sequences from the first and optionally the second product obtained in (a), or amplification products thereof, with each other and/or an untreated reference sequence to determine which Cs in the initial nucleic acid fragment are modified. A modified TET methylcytosine dioxygenase with improved efficiency compared to unmodified TET2 at converting methylcytosine to carboxymethylcytosine is also provided. | 2021-12-16 |
20210388434 | Compositions and Methods for Detecting Molecular Targets on Chromosomal DNA - Compositions, methods and kits are provided for identifying the presence and location of a target in chromosomal DNA. A nicking endonuclease fused to a binding domain that binds to a constant region of an antibody (NEFP) is provided that may be used for binding to a target directly or via an antibody that binds to the target. The target may be a protein or structural feature of the DNA and its presence and location may correspond to a phenotype and/or pathology in a biopsy or other cell sample for diagnostic purposes. The background is reduced by the addition of a glycoaminoglycan (GAG) that reversibly inhibits binding of the NEFP to DNA. Nick translation in the presence of a strand displacing polymerase enables the incorporation of tagged nucleotides that (i) blocks re-nicking; (ii) facilitates immobilization of DNA fragments around the target for sequencing; and/or (iii) enables dye labelling of the chromosomal DNA within the cell nuclei for analysis by microscopy. | 2021-12-16 |
20210388435 | COMPOSITIONS AND METHODS FOR ACCURATELY IDENTIFYING MUTATIONS - The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods. | 2021-12-16 |
20210388436 | PROBE HAVING OCTAMINE OR OCTAMINE DERIVATIVE BOUND THERETO, AND USES OF SAME - The present invention relates to a probe having octamine or octamine derivative bound thereto in addition to a reporter and a quencher to thus allow the quencher to more effectively suppress light emitted by the reporter, and to uses of the probe. When the probe according to the present invention is utilized, octamine or octamine derivative bound to the probe effectively suppresses the light emitted by the quencher for the reporter, and results in effects such as i) a reduction in base fluorescence, ii) an increase in delta fluorescence, and iii) a decrease in the value of cycle at threshold, thus allowing the probe to be effectively used in a variety of real-time polymerase chain reactions requiring accuracy and sensitivity. | 2021-12-16 |
20210388437 | TYPE V CRISPR/CAS EFFECTOR PROTEINS FOR CLEAVING SSDNAS AND DETECTING TARGET DNAS - Provided are compositions and methods for detecting a target DNA (double stranded or single stranded) in a sample. In some embodiments, a subject method includes: (a) contacting the sample with: (i) a type V CRISPR/Cas effector protein (e.g., a Cas12 protein such as Cas12a, Cas12b, Cas12c, Cas12d, Cas12e); (ii) a guide RNA (comprising a region that binds to the type V CRISPR/Cas effector protein, and a guide sequence that hybridizes with the target DNA); and (iii) a detector DNA that is single stranded (i.e., a “single stranded detector DNA”) and does not hybridize with the guide sequence of the guide RNA; and (b) measuring a detectable signal produced by cleavage (by the type V CRISPR/Cas effector protein) of the single stranded detector DNA. Also provided are compositions and methods for cleaving single stranded DNAs (e.g., non-target ssDNAs), e.g., inside of a cell. | 2021-12-16 |
20210388438 | METHOD FOR SELECTING NEOEPITOPES - The present invention relates to a method for selecting neoepitopes for an individual, by selecting MHC I and/or MHC II binding neoepitopes and ranking them with respect the methods as described herein. | 2021-12-16 |
20210388439 | METHOD FOR DIAGNOSIS AND SUBTYPING OF ADULT ONSET STILL'S DISEASE - The invention relates to method of diagnosis a subject suffering from Adult-onset Still's disease and further to determine the disease course of the subject suffering from Adult-onset Still's disease. | 2021-12-16 |
20210388440 | Method For Estimating A Risk For A Subject Suffering From Encapsulating Peritoneal Sclerosis, Analyzer And Kit Thereof - A method for estimating a risk for a subject suffering from encapsulating peritoneal sclerosis is provided, including measuring an expression level of at least one microRNA from a sample of the subject, and the microRNA is selected from miR-17, miR-100, miR-155, miR-202, miR-422a, and miR-483; comparing the expression level of the microRNA in the sample to that of a same miRNA of a control, when the expression level of miRNA in the sample is lower than that of the control, the subject is estimated having the risk of encapsulating peritoneal sclerosis. A kit for estimating a risk for a subject suffering from encapsulating peritoneal sclerosis is also provided, including at least one agent for identifying the at least one microRNA as above mentioned from the sample of the subject. | 2021-12-16 |
20210388441 | PREDICTING CHRONIC ALLOGRAFT INJURY THROUGH ISCHEMIA-INDUCED DNA METHYLATION - The present invention relates to the identification of a specific set of CpG biomarkers for predicting the risk of developing chronic allograft injury in a patient, and means and methods for preservation of allografts and transplantation organs. In particular, a method to predict the risk of developing chronic allograft injury in a patient is presented based on cold-ischemia induced hypermethylation of CpGs as an important driver for downregulation of (promoters of) genes essential for organ preservation. Specifically, a CpG biomarker signature for hypermethylation of renal allograft organs caused by hypoxia and ischemia pre-implantation revealed treatment options of ischemia-associated chronic allograft injury and preservation of donor kidneys. | 2021-12-16 |
20210388442 | METHOD AND DEVICES FOR AGE DETERMINATION - The present invention relates to the determination of ages. Specifically, the present invention relates to a method for determining an age indicator, and a method for determining the age of an individual. Said methods are based on data comprising the DNA methylation levels of a set of genomic DNA sequences. Preferably, said age indicator is determined by applying on the data a regression method comprising a Least Absolute Shrinkage and Selection Operator (LASSO), preferably in combination with subsequent stepwise regression. Furthermore, the invention relates to an ensemble of genomic DNA sequences and a gene set, and their uses for diagnosing the health state and/or the fitness state of an individual and identifying a molecule which affects ageing. In further aspects, the invention relates to a chip or a kit, in particular which can be used for detecting the DNA methylation levels of said ensemble of genomic DNA sequences. | 2021-12-16 |
20210388443 | SEPSIS BIOMARKER PANELS AND METHODS OF USE - Methods for diagnosing and/or predicting presence of sepsis in a subject using a gene signature of three or more genes are provided. Also provided are sets containing specific binding molecules for each of the three or more genes, and kits containing such sets. | 2021-12-16 |
20210388444 | FUS/TLS-BASED COMPOUNDS AND METHODS FOR DIAGNOSIS, TREATMENT AND PREVENTION OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED MOTOR NEURON DISEASES - The invention provides novel FUS/TLS nucleic acids and proteins that comprise one or more genetic markers (for example, single nucleotide polymorphisms) and methods of use thereof including methods relating to the diagnosis of ALS or other related motor neuron disease by virtue of the presence of the mutant FUS/TLS sequence(s). | 2021-12-16 |
20210388445 | COMPOSITIONS AND METHODS FOR CANCER AND NEOPLASIA ASSESSMENT - The present disclosure relates to certain compositions, kits, devices, systems and methods, e.g., certain compositions, kits, devices, systems and methods for assessing cancer or neoplasia in a subject. In particular aspects, provided herein are compositions, kits, devices, systems and methods for assessing cancer or neoplasia in a subject based on assessing methylation status of selected target polynucleotide sequences, e.g., target genomic DNA sequences, from the subject. | 2021-12-16 |
20210388446 | Methods and Systems for Detecting Biological Components - Methods for the detection of components from biological samples are provided. In certain aspects, the methods may be used to detect and/or quantify specific components in a biological sample, such as tumor cells (e.g., circulating tumor cells). Systems and devices for practicing the subject methods are also provided. | 2021-12-16 |
20210388447 | LIPID-MODIFIED OLIGONUCLEOTIDES AND METHODS OF USING THE SAME - Disclosed are compositions comprising a first lipid-conjugated oligonucleotide comprising a first lipid moiety, a first hybridization region, and a first primer region; a second lipid-conjugated oligonucleotide comprising a second hybridization region and a second lipid moiety, wherein the second hybridization region is the reverse complement of the first hybridization region; and a third oligonucleotide comprising a second primer region, a barcode region, and a capture sequence, wherein the second primer region is the reverse complement of the first primer region; compositions comprising a lipid-conjugated DNA oligonucleotide comprising a lipid moiety, a barcode region, and a capture sequence; and composition comprising a first lipid-conjugated DNA oligonucleotide comprising a lipid moiety and a first primer region; and a second DNA oligonucleotide comprising a second primer region, a barcode region, and a capture sequence, wherein the second primer region is the reverse complement of the first primer region. Also disclosed are membranes and cells comprising such compositions and uses of such compositions. | 2021-12-16 |
20210388448 | METHOD OF DETERMINING PROGNOSIS IN PATIENTS WITH FOLLICULAR LYMPHOMA - A method is disclosed for determining prognosis for a patient suffering from follicular lymphoma, that determines the amount of miR-31 in a biological sample taken from the body of the patient, and assigns the patient to a prognostic group based on the determined amount of miR-31, wherein the prognostic groups and the threshold values for assignment to the prognostic groups are obtained by analyzing the amount of miR-31 in biological samples of patients with known prognosis. In the biological sample taken from the patient, the miR-31 expression may be determined along with the expression of an endogenous control, which is a small nuclear RNA or stably expressed miRNA, and, in case of absolute quantification, the expression of synthetic standards of these miRNAs and endogenous controls of known number of molecules are determined. The method allows the assignment of patients to prognostic groups by determining miR-31 expression. | 2021-12-16 |
20210388449 | DETECTING CANCER CELL OF ORIGIN - Methods and compositions are provided for determining a pan-cancer clustering of cluster assignment (COCA) subtype of a cancer in an individual by detecting the expression level of at least one classifier biomarker selected from a group of classifier biomarkers for COCA subtypes. Also provided herein are methods and compositions for determining the response of an individual with a COCA subtype to a therapy such as immunotherapy. | 2021-12-16 |
20210388450 | BIOMARKER PANEL FOR DETERMINING MOLECULAR SUBTYPE OF LUNG CANCER, AND USE THEREOF - The present invention relates to a biomarker panel for determining a molecular subtype of cancer and a method of predicting prognosis of cancer using the panel. The biomarker panel identifies molecular subtypes of tumors by selecting and analyzing only information on tumor cells from single-cell transcriptome data derived from patients with early lung cancer, thereby allowing prediction of the prognosis of lung cancer and prediction of the response to anti-cancer agents. Therefore, the biomarker panel may be used for selecting a treatment regimen. | 2021-12-16 |
20210388451 | METHODS FOR ANALYSIS OF CELL-FREE RNA - Methods for measuring subpopulations of cell-free ribonucleic acid (RNA) molecules are provided. In some embodiments, methods of generating a sequencing library from a plurality of RNA molecules in a test sample obtained from a subject are provided, as well as methods for analyzing the sequencing library to detect, e.g., the presence or absence of a disease. | 2021-12-16 |
20210388452 | METHOD FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF PROSTATE CANCER METASTASIS - The present invention relates to a method for the diagnosis or the prognosis of metastasis, relapse or recurrence in prostate cancer which comprises determining if the c-MAF gene is amplified in a primary tumor sample. Likewise, the invention also relates to a method for the diagnosis or the prognosis of metastasis, relapse or recurrence in prostate cancer, as well as to a method for determining the tendency to develop bone metastasis with respect to metastasis in other organs, which comprise determining the c-MAF expression level. Finally, the invention relates to the use of a c-MAF inhibitor as therapeutic target for treating the prostate cancer. | 2021-12-16 |
20210388453 | CONTROLS FOR NUCLEIC ACID ASSAYS - The present invention features a method and kit for isolating microvesicles or extracting microvesicle nucleic acids from a biological sample by using a control particle. The present invention provides control particles that are viruses or virus-like particles, such as bacteriophages, that contain control nucleic acids that can be detected to assess the accuracy, reliability, and efficiency of the microvesicle isolation or nucleic acid extraction steps. The methods described herein may further comprise the analysis of the presence, absence, or level of at least one biomarker associated with a disease or medical condition for diagnosing, prognosing, or monitoring the disease or medical condition. | 2021-12-16 |
20210388454 | RAPID DIAGNOSTIC SYSTEM USING TARGETED ANTISENSE OLIGONUCLEOTIDE CAPPED PLASMONIC NANOPARTICLES - The present disclosure relates to a nanotechnology-based molecular sensing system, compositions, and methods that can be adapted to accurately detect a target gene in clinical samples, using anti-sense oligonucleotide capped plasmonic nanoparticles for selective detection of biological pathogens. | 2021-12-16 |
20210388455 | Kobophenol A for the treatment of Corona Virus 2 (SARS-CoV-2) infection - The present disclosure relates to an in-silico analysis for inhibitors of Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2). The in-silico screening of Kobophenol A confirmed the effective binding at two positions, firstly at ACE2/Spike interface and secondly at the hydrophobic pocket by destabilizing the complex formation. Kobophenol A inhibited the cell death caused by viral infection without inducing cell toxicity in the absence of viral infection. The molecular dynamics of Kobophenol A indicated the stability of binding of Kobophenol A through hydrogen bond and stabilized at Y495 and K353 with an average distance of 2.95 Å. The binding affinity of Kobophenol A to the ACE2/Spike interface region and the ACE2 hydrophobic pocket is computed to be −19.0±4.3 and −24.9±6.9 kcal/mol respectively. Kobophenol A is useful as a potential drug for treatment of COVID-19. | 2021-12-16 |
20210388456 | METHOD FOR PRODUCING NON-ORIENTED ELECTRICAL STEEL SHEET - A non-oriented electrical steel sheet is produced by subjecting a steel slab containing, in mass %, C: not more than 0.0050%, Si: 1.0 to 6.5%, Mn: 0.05 to 2.0%, S: not more than 0.0050%, Al: not more than 0.01%, N: not more than 0.0050%, Ti: not more than 0.0030%, Nb: not more than 0.0030% and O: not more than 0.0050% to a hot rolling, a cold rolling and a finish annealing, the finish annealing conducted under conditions that a soaking temperature T (° C.) satisfies the following equation (1): | 2021-12-16 |
20210388457 | STEEL PLATE FOR PRESSURE VESSEL WITH EXCELLENT CRYOGENIC TOUGHNESS AND EXCELLENT DUCTILITY AND MANUFACTURING METHOD THEREOF - Provided are a steel plate for a pressure vessel with excellent cryogenic toughness and excellent ductility, and a manufacturing method thereof. The steel plate for a pressure vessel of the present invention comprises, in weight %, 0.05 to 0.15% of C; 0.20 to 0.40% of Si; 0.3 to 0.6% of Mn; 0.001 to 0.05% of Al; 0.012% or less of P; 0.015% or less of S; 4.0 to 5.0% of Ni; 0.001 to 0.10% of In; and the balance being Fe and unavoidable impurities, wherein a steel microstructure consists of 15 to 80 area % of tempered bainite and the balance being tempered martensite. | 2021-12-16 |
20210388458 | HIGH STRENGTH STEEL PLATE FOR STRUCTURE WITH GOOD SEAWATER CORROSION RESISTANT PROPERTY AND METHOD OF MANUFACTURING SAME - The present invention provides a high strength steel plate for a structure and a method of manufacturing same, wherein the high strength steel plate fora structure comprises, by weight %, 0.03% (inclusive) to 0.1% (exclusive) of C, 0.1% (inclusive) to 0.8% (exclusive) of Si, 0.3% (inclusive) to 1.5% (exclusive) of Mn, 0.5% (inclusive) to 1.5% (exclusive) of Cr, 0.1% (inclusive) to 0.5% (exclusive) of Cu, 0.01% (inclusive) to 0.08% (exclusive) of Al, 0.01% (inclusive) to 0.1% (exclusive) of Ti, 0.05% (inclusive) to 0.1% (exclusive) of Ni, 0.002% (inclusive) to 0.07% (exclusive) of Nb, 0.03% or less of P, 0.02% or less of S, and the balance of Fe and unavoidable impurities, and has a microstructure comprising, by area fraction, 20% or more of bainite, less than 80% of polygonal ferrite and acicular ferrite in total, and less than 10% of pearlite and MA as the other phases. | 2021-12-16 |
20210388459 | METHOD FOR MANUFACTURING GRAIN-ORIENTED ELECTRICAL STEEL SHEET - A method for manufacturing a grain-oriented electrical steel sheet includes: a silicon steel material production process of producing a silicon steel material; a hot rolling process of obtaining a hot rolled sheet by subjecting the silicon steel material to hot rolling; a cold rolling process of obtaining a steel sheet having a final sheet thickness by subjecting the hot rolled sheet to a single cold rolling process or to multiple cold rolling processes having intermediate annealing performed between cold rolling processes; a decarburization annealing process of subjecting the steel sheet to decarburization annealing using a decarburization annealing furnace including a heating area and a soaking area; and a final annealing process of applying an annealing separator having alumina as a main component to the steel sheet and subjecting the steel sheet to final annealing, wherein, in the decarburization annealing process, when X represents the Cr content of the silicon steel material in terms of mass %, an oxidation degree P1 of an atmosphere gas in the heating area satisfies the following Expression 1 and an oxidation degree P2 of an atmosphere gas in the soaking area satisfies the following Expression 2: | 2021-12-16 |
20210388460 | Method for Producing a Stainless Steel Sheet with Modified Visual Characteristics - A method for producing a patterned stainless steel sheet with improved visual characteristics in the wavelength area of visible light including providing a deformed stainless steel sheet; performing a heat treatment on the deformed stainless steel sheet, wherein the heat treatment is conducted at a temperature of 900-1200° C.; performing a mechanical treatment on at least one surface of the heat treated stainless steel sheet; transferring the mechanically treated stainless steel sheet to a patterning process, wherein, in the patterning process, at least one side of the mechanically treated stainless steel sheet is patterned using a patterning roll having a surface with an emboss depth of up to 100 micrometers to provide a patterned stainless steel sheet; and performing a heat treatment on the patterned stainless steel sheet, wherein the heat treatment is conducted at a temperature range of 900-1200° C., wherein the mechanical treatment is carried out by blasting. | 2021-12-16 |
20210388461 | METHOD FOR RECOVERING VALUABLES - A method for recovering valuables, which can suppress the loss of valuables in recovering the valuables is provided. The method for recovering valuables of the disclosure comprises: a preparation step of preparing a treatment object including a valuables-containing member that contains valuables on or above a surface of a base material; an immersion step of immersing the treatment object in a liquid such that the valuables-containing member of the treatment object is disposed in the liquid; a collection step of irradiating the valuables-containing member of the treatment object immersed in the liquid with laser light through the liquid so as to remove the valuables-containing member from the treatment object, thereby collecting removed matter of the valuables-containing member into the liquid; and a recovery step of recovering the removed matter of the valuables-containing member from the liquid. | 2021-12-16 |
20210388462 | PROCESS FOR THE SELECTIVE RECOVERY OF TRANSITION METALS FROM ORGANIC RESIDUES - There is a process for the selective recovery of transition metals from an organic stream containing transition metals. The organic stream and possibly a first extractor if solid, are melted up to the liquid state. The extractor consists of an ionic liquid or a mixture of two or more ionic liquids and the ionic liquid contains an ammonium salt as cation and as anion an anion with chelating properties. A melted organic stream and a first extractor, optionally melted, are fed to a first liquid-liquid extraction unit working at a temperature of at least 150° C. where the liquid-liquid extraction is carried out obtaining a liquid mixture containing an ionic liquid, or a mixture of two or more ionic liquids, and metals. After extraction, the liquid mixture is cooled at a temperature between 0° C. and 70° C. and becomes biphasic; then the cooled mixture is sent to a first separation unit, to separate a liquid phase that contains ionic liquids and metals, and a metal-depleted solid phase. After the first separation, the separated metal-depleted solid phase is optionally sent to a washing unit to which a solvent is fed, so as to eliminate the residual ionic liquid by transferring it into the solvent and obtaining a metal-depleted solid phase. Then the separate liquid phase containing ionic liquids and metals is sent into a liquid-liquid precipitation and separation unit, adding a counter-solvent, thereby obtaining a solid phase containing the metals and a liquid stream containing counter-solvent and ionic liquids. | 2021-12-16 |
20210388463 | METHOD AND SYSTEM FOR ASH TREATMENT - A method of the invention for treatment of particulate material for metal recovery includes heating a furnace to a first temperature, feeding a particulate material into the furnace, and before or after heating of the raw material, feeding a reducing gas flow through the furnace. The particulate material is heated in the furnace for volatilizing one or more metals contained in the ash into the gas flow, and the volatilized particles are recovered in one or more collection units. A system for treatment of particulate material for metal recovery includes a heated furnace for receiving flows of reduction gas and particulate material, a collection unit for volatilized particles, and a collection unit for non-volatilized material. | 2021-12-16 |
20210388464 | CONCENTRATION OF PRECIOUS METALS AND RARE EARTH ELEMENTS - Methods of recovering precious metals from unconventional feed water sources. In approaches, the methods use a combination of one or more of ultrafiltration, nanofiltration, and/or reverse osmosis membranes. The unconventional feed water source may be salt lake brines, coal-fired plant flue-gas scrubber blowdown water, high salinity brines, concentrated brine from desalination of seawater and the like sources. The recovered precious metals may include gold tetrachloride, gold sulfate, silver tetrachloride, silver sulfate, rare earth elements, or mixtures thereof. | 2021-12-16 |
20210388465 | MEMBRANE ELECTRODE MATERIAL, ITS PREPARATION METHOD AND APPLICATION IN LITHIUM EXTRACTION BY ADSORPTION-ELECTROCHEMICAL COUPLING TECHNOLOGY - This invention provides a membrane electrode material and its preparation method, as well as the application of the material into lithium extraction by adsorption-electrochemical coupling method. The membrane electrode material is described as MnO@C. The preparation steps are as follows: LiMn | 2021-12-16 |
20210388466 | Process For Purifying And Concentrating Rare Earths From Phosphogypsum - The present invention relates to a process for purifying and concentrating rare earths contained in phosphogypsum, characterised in that it comprises the following steps of:
| 2021-12-16 |
20210388467 | Ni-Based Forged Alloy Article and Turbine High-Temperature Member Using Same - An objective of the invention is to provide a Ni-based forged alloy article based on a superhigh precipitation-strengthening Ni-based alloy material that has mechanical properties balanced at higher level than before, and a turbine high-temperature member formed of the forged alloy article. There is provided a Ni-based forged alloy article comprising crystal grains of the γ phase and precipitation particles of the γ′ phase, and having a chemical composition enabling to precipitate a γ′ phase in an amount of 50-70 volume % at 700° C. within a matrix of a γ phase. The γ′ phase comprises: aging precipitation γ′ phase particles precipitating within the γ phase grains; and eutectic reaction γ′ phase particles precipitating between/among the γ phase grains. The eutectic reaction γ′ phase particles comprise a higher content of Ni and Al than the aging precipitation γ′ phase particles and have an average particle size of 2 to 40 μm. | 2021-12-16 |
20210388468 | HIGH STRENGTH RECYCLED ALUMINUM ALLOYS FROM MANUFACTURING SCRAP WITH COSMETIC APPEAL - The disclosure provides an aluminum alloy including iron (Fe) in an amount of 0.10 wt % to 0.50 wt %; silicon (Si) in an amount of 0.50 wt % to 1.00 wt %; magnesium (Mg) in amount of 0.50 wt % to 0.90 wt %; one of manganese (Mn) or chromium (Cr) in amount from 0.040 to 0.500 wt %; additional non-aluminum (Al) elements in an amount not exceed 3.5 wt %; and the remaining wt % being Al and incidental impurities, wherein the alloy has a Mg/Si ratio of equal to or greater than 0.90. | 2021-12-16 |
20210388469 | NANO-TREATMENT OF HIGH STRENGTH ALUMINUM ALLOYS FOR MANUFACTURING PROCESSES - A metal matrix nanocomposite includes: (1) a matrix including an aluminum alloy; and (2) nanostmctures dispersed in the matrix, wherein the matrix includes grains having aspect ratios of about 3 or less. Manufacturing processes include subjecting the nanocomposite to solidification processing, fusion welding, extrusion, thixocasting, additive manufacturing, and heat treatment. | 2021-12-16 |
20210388470 | METAL SHEET MADE OF HIGH-STRENGTH 2XXX ALLOY FOR AN AIRCRAFT FUSELAGE - The invention relates to a thin metal sheet which is made of an alloy based on substantially recrystallized aluminum and which has a thickness of 0.25 to 12 mm, the alloy comprising, in percent by weight, Cu 3.4-4.0; Mg 0.5-0.8; Mn 0.1-0.7; Fe #0.15; Si #0.15; Zr #0.04; Ag #0.65; Zn #0.5; inevitable impurities #0.05 each and #0.15 in total, the remainder consisting of aluminum. The invention also relates to a process for manufacturing such a metal sheet and to the use thereof as a fuselage panel or sheet metal for the production of composite products such as fiber metal laminates (FML) for wing or fuselage applications in the aeronautical industry. | 2021-12-16 |
20210388471 | ALUMINUM ALLOY, WIRE AND CONNECTING ELEMENT MADE OF THE ALUMINUM ALLOY - An aluminum alloy for manufacturing wire for cold forming, in particular for manufacturing connecting elements, includes an alloy content of aluminum greater than 88 mass % and an alloy content of copper greater than or equal to 5 mass % as main alloy elements. The aluminum alloy contains no boron. Nickel and silicon are additional alloy elements, with an alloy content of nickel greater than or equal to 0.15 mass %, and an alloy content of silicon less than or equal to 1.0 mass %. A wire for manufacturing connecting elements or screws and a connecting element or screw made of the aluminum alloy are also provided. | 2021-12-16 |
20210388472 | CEMENTED CARBIDE FOR HIGH DEMAND APPLICATIONS - Provided is a corrosion, erosion and wear resistant cemented carbide for high demand applications including, for example, use as a component within oil and gas production. The cemented carbide includes a hard phase and a binder phase. The cemented carbide may include, for example. Ni, Cr and Mo. The binder phase content of the cemented carbide is between 7 to 11 wt %. The WC of the cemented carbide may have an average grain size of from 0.1 to 2 μm. | 2021-12-16 |
20210388473 | IRON ALLOY MANUFACTURING METHOD - An iron alloy manufacturing method which can suppress occurrence of distortion and crack in formed iron alloy layers is provided. During execution of a forming step, in a first temperature control step, an iron alloy layer temperature T | 2021-12-16 |
20210388474 | HIGH MAGNETIC FLUX DENSITY SOFT MAGNETIC FE-BASED AMORPHOUS ALLOY - According to the present invention, provided is a high magnetic flux density soft magnetic Fe-based amorphous alloy represented by a composition formula of the following formula (I): | 2021-12-16 |
20210388475 | CRYOGENIC AUSTENITIC HIGH-MANGANESE STEEL HAVING EXCELLENT CORROSION RESISTANCE, AND MANUFACTURING METHOD THEREFOR - The cryogenic austenitic high-manganese steel having excellent corrosion resistance, according to one aspect of the present invention, comprises 0.2-0.5 wt % of C, 23-28 wt % of Mn, 0.05-0.5 wt % of Si, 0.03 wt % or less of P, 0.005 wt % or less of S, 0.5 wt % or less of Al, and 3-4 wt % of Cr, with the remainder being Fe and other unavoidable impurities, also comprises at least 95 area % of austenite as a microstructure, and has Cr concentration sections continuously formed within an area of 50 μm in the thickness direction from the surface, wherein the | 2021-12-16 |
20210388476 | STRIP OF A COBALT IRON ALLOY, LAMINATED CORE AND METHOD OF PRODUCING A STRIP OF A COBALT IRON ALLOY - A method of producing a strip from a CoFe alloy is provided. A slab consisting substantially of 35 wt %≤Co≤55 wt %, 0 wt %≤V≤3 wt %, 0 wt %≤Ni≤2 wt %, 0 wt %≤Nb≤0.50 wt %, 0 wt %≤Zr+Ta≤1.5 wt %, 0 wt %≤Cr≤3 wt %, 0 wt %≤Si≤3 wt %, 0 wt %≤Al≤1 wt %, 0 wt %≤Mn≤1 wt %, 0 wt %≤B≤0.25 wt %, 0 wt %≤C≤0.1 wt %, the remainder being Fe and up to 1 wt % of impurities, is hot rolled and then quenched from a temperature above 700° C. to less than 200° C. The hot rolled strip is cold rolled. The cold rolled strip is stationary annealed to produce an intermediate strip, and the intermediate strip is continuously annealed. | 2021-12-16 |
20210388477 | HOT-DIP PLATING METHOD - Provided is a hot-dip plating method that achieves good plating wettability between a metal material and a hot-dip plating bath and that makes it possible to reduce the amount of consumed energy as compared to conventional techniques. In a plating step included in the hot-dip plating method, vibration is applied to a hot-dip plating bath such that the ratio of the average sound pressure level (excluding noise) over ranges each lying between sound pressure peaks at harmonic frequencies of a fundamental frequency to the average sound pressure level (excluding noise) over the measured frequency range in an acoustic spectrum is greater than 0.2. | 2021-12-16 |
20210388478 | Preparation Method of a Zirconium-Titanium-Based Alloy Embedded Aluminized Layer - The present invention provides a preparation method of a zirconium-titanium-based alloy embedded aluminized layer, and relates to the technical field of metal surface modification. The preparation method provided by the invention comprises the following steps: putting a zirconium-titanium-based alloy and an aluminiferous penetrant into a mould from bottom to top in the sequence of a first penetrant layer, a first zirconium-titanium-based alloy, a second penetrant layer, a second zirconium-titanium-based alloy and a third penetrant layer, and compacting to obtain a mixed sample; sequentially covering the surface of the mixed sample with activated carbon powder and alkali metal halide, and then sequentially carrying out heat treatment and cooling to obtain a zirconium-titanium-based alloy embedded aluminized layer. The preparation method provided by the invention does not need to adopt a special heating furnace or carry out heat treatment under a vacuum condition in the actual application process, simplifies the operation process and the operation condition, has small technical difficulty and small equipment investment, and is suitable for large-scale production and application. | 2021-12-16 |
20210388479 | FULL-SIZE MASK ASSEMBLY AND MANUFACTURING METHOD THEREOF - Disclosed herein is a full-size mask assembly and a manufacturing method thereof. The full-size mask assembly according to an embodiment of the present invention includes a frame having a frame opening formed therein and a support surrounding the frame opening, a structural auxiliary mask supported by the support and having a plurality of shafts in a grid shape to form a plurality of structural auxiliary mask openings, and a plurality of cell unit masks supported by the structural auxiliary mask and each of which has a deposition pattern portion through which a deposition material passes. | 2021-12-16 |
20210388480 | HIGH-PERFORMANCE WAFER-LEVEL LEAD SULFIDE NEAR INFRARED PHOTOSENSITIVE THIN FILM AND PREPARATION METHOD THEREOF - Provided are a method for preparing a high-performance wafer-level lead sulfide near infrared photosensitive thin film. Firstly, a surface of the selected substrate material is cleaned; next, a vaporized oxidant is introduced into a vacuum evaporation chamber under a high background vacuum degree, and a Pbs thin film is deposited on the clean substrate surface to obtain a microstructure with medium particle, loose structure and consistent orientation. Finally, under a given temperature and pressure, a high-performance wafer-level Pbs photosensitive thin film is obtained by sensitizing the film prepared at step S | 2021-12-16 |
20210388481 | PVD Coatings with a HEA Ceramic Matrix with Controlled Precipitate Structure - The present invention discloses a PVD coating process for producing a multifunctional coating structure comprising the steps of producing a HEA ceramic matrix on a substrate and the targeted introduction of a controlled precipitate structure into the HEA ceramic matrix to generate a desired specific property of the coating structure. | 2021-12-16 |
20210388482 | Vanadium Aluminium Nitride (VAlN) Micro Alloyed with Ti and/or Si - The present invention discloses a high-temperature stable ceramic coating structure including a microalloy comprising the elements Al, V and N producible by a gas phase deposition process. | 2021-12-16 |
20210388483 | METHOD FOR PRODUCING A COATED CUTTING TOOL - A method for producing a coated cutting tool includes depositing on every flank face and every rake face of the cutting tool an Al | 2021-12-16 |
20210388484 | ANTI-MICROBIAL COATING PHYSICAL VAPOR DEPOSITION SUCH AS CATHODIC ARC EVAPORATION - A bioactive coated substrate includes a base substrate, an outermost bioactive layer disposed over the base substrate, and a topcoat layer disposed on the outermost bioactive layer. Characteristically, the topcoat layer defines a plurality of pinholes that expose the outermost bioactive layer. A method for forming the bioactive coated substrate is also provided. | 2021-12-16 |
20210388485 | METHOD FOR PREPARING BACTERICIDAL FILM ON FIBER CLOTH - A method for preparing a bactericidal film on fiber cloth, comprising cleansing a reel of fiber cloth; placing the reel of fiber cloth into a vacuum chamber; supplying a DC power and a mid-frequency power; introducing argon gas to increase the chamber pressure to 0.3 Pa; position sputtering targets in the following order: silicon target, silicon carbide target, silver target, silicon carbide target, silver target, silicon carbide target and silver target, and then sputtering the targets simultaneously; wherein the silicon targets act as a bonding layer between the bactericidal film and the substrate; stopping the silicon targets, the silicon carbide targets and the silver targets first, and then turning off the argon gas; injecting air into the chamber until the pressure in the chamber and the atmospheric pressure are balanced. | 2021-12-16 |
20210388486 | EVAPORATOR BOAT CONTROL SYSTEM, PVD MACHINE AND METHOD OF OPERATING THE PVD MACHINE - The invention relates to a system for controlling evaporator boats, having a fixture ( | 2021-12-16 |
20210388487 | METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE, SUBSTRATE PROCESSING APPARATUS, AND RECORDING MEDIUM - There is provided a technique capable of forming a low resistance film. The technique includes sequentially repeating: a first step including a first process of supplying a reducing gas containing silicon and hydrogen and not containing halogen, in parallel with supply of a metal-containing gas, to a substrate in a process chamber; a second step including: a second process of stopping the supply of the metal-containing gas, and maintaining the supply of the reducing gas; and a third process of supplying an inert gas into the process chamber with the supply of the reducing gas stopped, and maintaining a pressure in the third process equal to a pressure in the second process or adjusting the pressure in the third process to a pressure different from the pressure in the second process; and a third step of supplying a nitrogen-containing gas to the substrate. | 2021-12-16 |
20210388488 | METHOD OF GROWING TWO-DIMENSIONAL TRANSITION METAL CHALCOGENIDE FILM AND METHOD OF MANUFACTURING DEVICE INCLUDING THE SAME - Provided are a method of growing a two-dimensional transition metal chalcogenide (TMC) film and a method of manufacturing a device including the two-dimensional TMC film. The method of growing a two-dimensional TMC film includes placing a metal layer having a predetermined pattern on a surface of a substrate; separately supplying a chalcogen precursor to a reaction chamber provided with the substrate; supplying a transition metal precursor to the reaction chamber; and evacuating the chalcogen precursor, the transition metal precursor, and by-products generated therefrom from the reaction chamber, wherein an amount of the chalcogen precursor and an amount of the transition metal precursor supplied to the reaction chamber may be controlled. | 2021-12-16 |
20210388489 | Methods for Depositing a Conformal Metal or Metalloid Silicon Nitride Film and Resultant Films - Described herein are conformal films and methods for forming a conformal metal or metalloid doped silicon nitride dielectric film wherein the conformal metal is zirconium, hafnium, titanium, tantalum, or tungsten. A method includes providing a substrate in a reactor; introducing into the reactor an at least one metal precursor which reacts; purging the reactor with a purge gas; introducing into the reactor an organoaminosilane precursors to react on at least a portion of the surface of the substrate to provide a chemisorbed layer; introducing a plasma comprising nitrogen and an inert gas into the reactor to react with at least a portion of the chemisorbed layer and provide at least one reactive site wherein the plasma is generated; and optionally purge the reactor with an inert gas; and the steps are repeated until a desired thickness of the conformal metal nitride film is obtained. | 2021-12-16 |
20210388490 | LAMINATED BODY, FLEXIBLE ELECTRONIC DEVICE, AND LAMINATED-BODY MANUFACTURING METHOD - The present disclosure relates to a laminated body including at least a base material layer containing at least a flexible base material and an inorganic thin film layer, in which a distribution curve of I | 2021-12-16 |
20210388491 | DEGRADABLE RESIN MOLDING AND PRODUCTION METHOD FOR DEGRADABLE RESIN MOLDING - Disclosed is a degradable film ( | 2021-12-16 |
20210388492 | REACTION CHAMBER COMPRISING A ROTATING ELEMENT FOR THE DEPOSITION OF A SEMICONDUCTOR MATERIAL - The reaction chamber ( | 2021-12-16 |
20210388493 | FILM FORMING APPARATUS AND FILM FORMING METHOD - A film forming apparatus for forming a film on a substrate includes a chamber, a substrate support, a gas supply unit, a gas injection member, and a filter. The substrate support is disposed in the chamber to support a substrate placed thereon and maintain the substrate at a film forming temperature. The gas supply unit is configured to supply a gas containing a film forming source gas. The gas injection member is disposed to face the substrate support and has a gas injection area for injecting the gas containing the film forming source gas supplied from the gas supply unit. Further, the filter is disposed to cover at least the gas injection area on a surface of the gas injection member opposite to a surface facing the substrate support, the filter being configured to trap particles in the gas containing the film forming source gas while the gas passes therethrough. | 2021-12-16 |
20210388494 | PROCESSING CHAMBER CONDITION AND PROCESS STATE MONITORING USING OPTICAL REFLECTOR ATTACHED TO PROCESSING CHAMBER LINER - A system includes a reflector attached to a liner of a processing chamber. A light coupling device is to transmit light, from a light source, through a window of the processing chamber directed at the reflector. The light coupling device focuses, into a spectrometer, light received reflected back from the reflector along an optical path through the processing chamber and the window. The spectrometer detects, within the focused light, a first spectrum representative of a deposited film layer on the reflector using reflectometry. An alignment device aligns, in two dimensions, the light coupling device with the reflector until maximization of the focused light received by the light coupling device. | 2021-12-16 |
20210388495 | ASYMMETRIC EXHAUST PUMPING PLATE DESIGN FOR A SEMICONDUCTOR PROCESSING CHAMBER - Exemplary semiconductor processing chambers may include a chamber body including sidewalls and a base. The chambers may include a substrate support extending through the base of the chamber body. The substrate support may include a support platen configured to support a semiconductor substrate. The substrate support may include a shaft coupled with the support platen. The chambers may include a foreline conduit offset from a center of the base for exhausting a gas from the chamber body, and an exhaust volume coupled to the foreline conduit. The chambers may include a pumping plate comprising a central aperture through which the shaft extends, and further comprising exit apertures for directing at least a portion of the gas from the chamber body to the exhaust volume. The exit apertures may be disposed at locations opposite the foreline conduit so as to reduce nonuniformity in gas flow. | 2021-12-16 |
20210388496 | MOUNTINGS FOR FULLY COATING BODIES, IN PARTICULAR STENTS, BY MEANS OF PECVD - A device for holding a plurality of workpieces, which each include a circumferential wall structure surrounding an interior, includes a plurality of rotatable holding elements for holding the workpieces. The holding elements are configured to secure the workpieces. The workpieces can be stents and the method of coating can be deposition, particularly plasma enhanced chemical vapor deposition. The holding elements can include at least one connecting element which facilitates electrical charging of the holding elements and hence workpieces when connected to the holding elements by being connected to a charging unit. | 2021-12-16 |
20210388497 | THIN LAYER DEPOSITION WITH PLASMA PULSING - Methods of depositing thin films for an electronic device, for example a semiconductor device include applying a first pulsed plasma with or without a reactant and a second continuous plasma with a reactant. | 2021-12-16 |
20210388498 | ATOMIC LAYER DEPOSITION AND VAPOR DEPOSITION REACTOR WITH IN-CHAMBER MICROPLASMA SOURCE - An in-chamber plasma source in a deposition reactor system includes an array of microcavity or microchannel plasma devices having a first electrode and a second electrode isolated from plasma in microcavities or microchannels. An inlet provides connection to deposition precursor. A region interacts deposition precursor with plasma. An outlet directs precursor dissociated with the plasma onto a substrate for deposition. A reactor system includes a substrate holder across from the outlet, a chamber enclosing the in-chamber plasma source and the substrate holder, an exhaust from the chamber, and conduit supplying precursors from sources or bubblers to the inlet. A reactor system can conduct plasma enhanced atomic layer deposition at high pressures and is capable of forming a complete layer in a single cycle. | 2021-12-16 |
20210388499 | LOW-K FILMS - Methods for plasma enhanced atomic layer deposition (PEALD) of low-K films are described. A method of depositing a film comprises exposing a substrate to a silicon precursor having the general formula (I) | 2021-12-16 |
20210388500 | METHOD AND APPARATUS FOR DEPOSITING A MULTI-SECTOR FILM ON BACKSIDE OF A SEMICONDUCTOR WAFER - A patterned backside stress compensation film having different stress in different sectors is formed on a backside of a substrate to reduce combination warpage of the substrate. The film can be formed by employing a radio frequency electrode assembly including plurality of conductive plates that are biased with different RF power and cause local variations in the plasma employed to deposit the backside film. Alternatively, the film may be deposited with uniform stress, and some of its sectors are irradiated with ultraviolet radiation to change the stress of these irradiated sectors. Yet alternatively, multiple backside deposition processes may be sequentially employed to deposit different backside films to provide a composite backside film having different stresses in different sectors. | 2021-12-16 |
20210388501 | SEMICONDUCTOR DEPOSITION MONITORING DEVICE - The present disclosure provides a semiconductor deposition monitoring device comprising a supporting table, a chamber, a lamp, an optical sensor, a conduit, a plurality of sensors in the conduit, and a heat exchanger. The supporting table supports a deposition target wafer on which a deposition material is deposited. The chamber comprises an upper dome and a lower dome. The lamp emits light to the chamber. The optical sensor receives the irradiated light and measures the deposition material formed in the chamber. The conduit has an inlet conduit through which air is injected into the chamber and an outlet conduit through which the air is discharged from the chamber. The plurality of sensors sense information of the air. The sensed information may be used to control the heat exchanger. | 2021-12-16 |
20210388502 | METHOD AND APPARATUS FOR DEPOSITING A MULTI-SECTOR FILM ON BACKSIDE OF A SEMICONDUCTOR WAFER - A patterned backside stress compensation film having different stress in different sectors is formed on a backside of a substrate to reduce combination warpage of the substrate. The film can be formed by employing a radio frequency electrode assembly including plurality of conductive plates that are biased with different RF power and cause local variations in the plasma employed to deposit the backside film. Alternatively, the film may be deposited with uniform stress, and some of its sectors are irradiated with ultraviolet radiation to change the stress of these irradiated sectors. Yet alternatively, multiple backside deposition processes may be sequentially employed to deposit different backside films to provide a composite backside film having different stresses in different sectors. | 2021-12-16 |
20210388503 | ATOMIC LAYER DEPOSITION AND ETCHING OF TRANSITION METAL DICHALCOGENIDE THIN FILMS - Vapor deposition methods for depositing transition metal dichalcogenide (TMDC) films, such as rhenium sulfide thin films, are provided. In some embodiments TMDC thin films are deposited using a deposition cycle in which a substrate in a reaction space is alternately and sequentially contacted with a vapor phase transition metal precursor, such as a transition metal halide, a reactant comprising a reducing agent, such as NH | 2021-12-16 |
20210388504 | SURFACE TREATMENT SOLUTION COMPOSITION CONTAINING TRIVALENT CHROMIUM AND INORGANIC COMPOUND, AND METHOD FOR MANUFACTURING HOT DIP GALVANIZED STEEL SHEET SURFACE-TREATED USING SAME - Provided is a surface treatment solution composition comprising: 30 to 51 wt % of a trivalent chromium compound comprising chromium phosphate (A) and chromium nitrate (B) and having a content ratio of A/(A+B) that satisfies 0.3 to 0.6; 5 to 15 wt % of silane coupling agent; 0.2 to 3 wt % of vanadium-based anti-corrosive rust inhibitor; 3 to 12 wt % of colloidal silica; 0.5 to 5 wt % of polysiloxane copolymer; and 14 to 61.3 wt % of water, a hot dip galvanized steel sheet surface-treated using same, and a manufacturing method thereof. The hot dip galvanized steel sheet treated with the surface treatment solution composition containing trivalent chromium has an excellent corrosion resistance, blackening resistance, pipe-forming oil reactivity, and alkali resistance. | 2021-12-16 |
20210388505 | Fastener Member - There is provided is a black metal fastener member that can be manufactured at low cost. A fastener member comprises a base material made of a copper alloy containing zinc at a concentration of 30% by mass or more and 43% by mass or less, and a black copper oxide coating covering at least a part of the base material. | 2021-12-16 |
20210388506 | PREPARATION METHOD FOR WEAR-RESISTANT COATING ON CYLINDRICAL INNER WALL SURFACE OF ALUMINUM ALLOY - A method for producing an abrasion-resistant coating on the inner wall of an aluminum alloy workpiece is provide. The steps include mixing a graphene powder and Al powder to obtain a mixed powder; combining and heating the mixed power with a polyvinyl alcohol (PVA) liquid, and performing spray granulation to obtain a low-temperature self-propagating composite; stirring a slurry comprising the low-temperature self-propagating composite and sodium silicate; injecting the slurry into a cylindrical inner cavity of an aluminum alloy workpiece mounted on a horizontal rotary table for rotation, the aluminum alloy workpiece is heated with the rotation at a second temperature of 80-100° C. so that the slurry is uniformly solidified on the cylindrical inner surface of the cylindrical inner cavity; and burning the slurry, after the slurry is uniformly solidified and while the rotation is maintained, with an oxyacetylene flame to form the wear-resistant coating. | 2021-12-16 |
20210388507 | Electronic Devices Having Corrosion-Resistant Coatings - An electronic device such as a wristwatch may include a conductive housing. A corrosion-resistant coating may be deposited on the conductive housing. The coating may include transition layers and an uppermost alloy layer. The transition layers may include a chromium seed layer on the conductive housing and a chromium nitride layer on the chromium seed layer. The uppermost alloy layer may include TiCrCN or other alloys and may provide the coating with desired optical reflection and absorption characteristics. The transition layers may include a minimal number of coating defects, thereby eliminating potential sites at which visible defects could form when exposed to salt water. This may allow the electronic device to exhibit a desired color and to be submerged in salt water without producing undesirable visible defects on the conductive housing structures. | 2021-12-16 |
20210388508 | TREATMENT LIQUID FOR SEMICONDUCTOR WITH RUTHENIUM AND METHOD OF PRODUCING THE SAME - Provided is a treatment liquid for a semiconductor with ruthenium, containing a hypobromite ion. Also provided is a treatment liquid for a semiconductor with ruthenium, containing at least a bromine-containing compound, an oxidizing agent, a basic compound, and water which are added and mixed, wherein the liquid has the bromine-containing compound added in an amount of 0.01 mass % or more and less than 2 mass % as a bromine element content with respect to the total mass of the liquid, has the oxidizing agent added in an amount of 0.1 mass % or more and 10 mass % or less with respect to the total mass, and has a pH of 8 or more and 14 or less. Further provided is a method of producing a treatment liquid for a semiconductor with ruthenium, including a step of mixing a bromine-containing compound with a solution containing a hypochlorous acid compound and a basic compound. | 2021-12-16 |
20210388509 | METHOD FOR PREVENTING CORROSION OF SPENT NUCLEAR FUEL CANISTER BY USING ELECTROLYTIC CORROSION PROTECTION - A method for preventing corrosion of a spent nuclear fuel canister by using electrolytic corrosion protection, according to the present invention, has an effect of enabling a semi-permanent operation and, particularly, has effects of preventing oxidation and corrosion problems of a canister made of a metal material, in consideration of various environmental variables that may cause corrosion, and ensuring the structural stability of the canister so as to enable a semi-permanent operation. | 2021-12-16 |
20210388510 | SHORT MESSAGE SERVICE TRANSCEIVER MODULE - A cathodic protection system comprising a short message system (SMS) transceiver. The SMS transceiver comprises a modem having a telephone number uniquely associated with it and a processor coupled to the modem. The processor is configured to retrieve sensor data from an input module of the cathodic protection system in response to an incoming SMS message from a remote telecommunication device when the incoming SMS message complies with a predetermined format. The processor is also configured to retrieve output voltage and current data from a rectifier monitor of the cathodic protection system in response to an incoming SMS message from the remote telecommunication device when the incoming SMS message complies with the predetermined format. The processor then sends the retrieved data to the remote telecommunication device via an outgoing SMS message. | 2021-12-16 |
20210388511 | PROCESS FOR ELECTROCHEMICAL PREPARATION OF AMMONIA - A process for preparing ammonia via an electrolysis cell may involve feeding nitrogen as a first reactant into the electrolysis cell and using water or water vapor as a second reactant for electrolysis. In at least one step downstream of the electrolysis, there is a separation of other components from the ammonia, such as an at-least-partial separation of nitrogen, water, argon and/or hydrogen. Recovery of the reactants is connected upstream of the ammonia electrolysis. The nitrogen used as the first reactant may be procured beforehand in an air fractionation plant. The process may further involve removing from the electrolysis cell oxygen formed as a by-product in the electrolysis at an anode. | 2021-12-16 |
20210388512 | PROCESS FOR SHORT CHAIN ALKANE SYNTHESIS WHILE MAINTAINING FARADAIC EFFICIENCY - There is disclosed a process for synthesis of a C2-8 alkane comprising: (a) providing an electrolyte formulation comprising from about 3N to about 6N C2-C5 carboxylic acid and from about 2 M to about 4 M alkali C2-C5 carboxylate, wherein the C2-C5 carboxylate and carboxylic acid have the same carbon alkyl length into a pressure vessel having an electrode cell or stack; (b) adding electrical current to the electrode cell or stack; (c) pressurizing the pressure vessel; and (d) recovering a gas stream from the pressure vessel comprising a C2-8 alkane, CO | 2021-12-16 |