49th week of 2021 patent applcation highlights part 39 |
Patent application number | Title | Published |
20210381965 | Far-Infrared Light Source and Far-Infrared Spectrometer - The present invention provides a far-infrared light source capable of reducing the shift in the location irradiated with far-infrared light even when the frequency of the far-infrared light changes. A far-infrared light source according to the present invention is configured so that the variation in the emission angle of far-infrared light in a nonlinear optical crystal when the frequency of the far-infrared light changes is substantially offset by the variation in the refractive angle of the far-infrared light at the interface between the nonlinear optical crystal and a prism when the frequency of the far-infrared light changes (see FIG. | 2021-12-09 |
20210381966 | A SYSTEM AND METHOD FOR DETERMINING A GAS CONCENTRATION IN A CONTAINER - An system and method is disclosed for determining a concentration of at least one gas in a container. The system and method includes detecting light reflected by a surface inside or behind the container, or light refracted or scattered by the container, with a detector, wherein the detector provides a first signal related to an intensity of the reflected light, and a second signal related to a position of reflected light being detected. The first and second signals are used for estimating a concentration of the at least one gas inside the container. | 2021-12-09 |
20210381967 | System and Method to Measure Refractive Index at Specific Wavelengths - Apparatus, methods and are disclosed for measuring refractive index of a material film. The method and apparatus utilize a reference measurement and as series of reflectance measurements at a range of wavelengths and thickness values for the material film to determine the refractive index of the material film. | 2021-12-09 |
20210381968 | INTERFEROMETRIC SCATTERING MICROSCOPY - Disclosed is an interferometric scattering microscope. The interferometric scattering microscope includes a remote refocusing system adapted to reproduce light collected by a high numerical aperture objective lens using another objective lens and thus can acquire an image of an object in a sample without vertical movement of the objective lens or the sample. | 2021-12-09 |
20210381969 | BIOPROCESS CONTAINER HAVING AN OPTICAL MEASURING DEVICE - The invention relates to a bioprocess container ( | 2021-12-09 |
20210381970 | METHOD FOR DETERMINING RELATIVE DEGREES OF REFLECTANCE OF A MEASUREMENT SURFACE - A method for determining relative degrees of reflectance of a measurement surface, having the method steps of applying measurement radiation to the measurement surface, such that a measurement spot is produced on the management surface, moving the measurement spot along at least a first straight measurement spot path, over the measurement surface in accordance with a first path movement and along a second straight measurement spot path with a second path movement, recording a first and second image sets of a plurality of locally resolved images of the measurement surface during the first path movement and the second path movement. An evaluation is carried out at intersection points, whose location points on the management surface are defined by evaluation lines, wherein a first group of straight evaluation lines within the first measurement path region and a second group of straight evaluation lines within the second measurement path region are predefined and/or determined. The evaluation lines of the first group are parallel to the first measurement spot path and the evaluation lines of the second group are parallel to the second measurement spot path, and each first group evaluation line has an intersection point with each second group evaluation line. For each intersection point, a maximum greyscale value is determined, and relative degrees of reflectance of the measurements surface are determined at least on a subset of the intersection points, depending on these greyscale values. | 2021-12-09 |
20210381971 | DEHAZE AND BACTERIOSTATIC FILM - A dehaze and bacteriostatic film includes a substrate material layer and a composite surface plasmon layer formed on the substrate material layer. The composite surface plasmon layer includes a particle stacked film layer and a particle suspension layer located on the substrate material layer, and the particle stacked film layer and the particle suspension layer jointly generate a composite surface plasmon wave. Accordingly, the composite surface plasmon wave is excited by visible light, so that different types of surface plasmon waves generated by the structures resonate and multiply with each other. The different surface plasmon waves add up to generate electromagnetic field intensity capable of dissociating spatial materials at a certain distance, such as water vapor to be partially ionized which is rich in hydroxide ions with effects of dehazing and inhibiting growth of bacteria. | 2021-12-09 |
20210381972 | NDIR SENSOR, SAMPLING METHOD AND SYSTEM FOR BREATH ANALYSIS - A gas sensor has a light detector, a gas-tight support structure enclosing the light detector, a window positioned in said support structure, and a light source mounted to the support structure. A sample area is positioned in the support structure to receive a gas to be tested. The light source is aligned with the window, sample area, and the light detector to pass light from the light source through the gas in the sample area to the light detector. The sensor can be provided in a breadth sampling apparatus that has deflects gas to a bypass route so that only a portion of gas reaches the sensor. | 2021-12-09 |
20210381973 | THALLIUM-GADOLINIUM-YTTRIUM NANODOT COMPOSITION - A fluorescent nanocomposite which includes a thallium doped gadolinium chalcogenide having formula Tl | 2021-12-09 |
20210381974 | QUANTUM DOT NANOCOMPOSITE CONTAINING BENZOTHIAZOLIUM - A fluorescent nanocomposite which includes a thallium doped gadolinium chalcogenide having formula Tl | 2021-12-09 |
20210381975 | METHOD AND DEVICE FOR INCREASING THE SENSITIVITY OF AN IN-LINE MEASUREMENT OF THE SURFACE CLEANLINESS OF STEEL STRIPS - A method for automated, in-line measurement of a differentiated surface cleanliness, in terms of carbon, of a continuously-moving metal sheet or strip, having a level of surface carbon pollution lower than 100 mg/m | 2021-12-09 |
20210381976 | MICROSPECTROSCOPIC DEVICE AND MICROSPECTROSCOPIC METHOD - A microspectroscopic device includes: a wavelength-tunable first light source configured to emit pump-light in a mid-infrared wavelength range; a second light source configured to emit probe-light in a visible range; a light source controller configured to change a wavelength of the infrared light source; a first optical system configured to combine the pump-light and the probe-light to acquired combined light and concentrate the combined light on a minute part of a sample; a second optical system configured to block at least the probe-light from transmitted light or reflected light of the sample; a detector configured to detect light incident thereon from the second optical system; a first spectrum acquisition means configured to acquire a spectrum of the incident light during the probe-light emission to the sample as a Raman spectrum or a fluorescence spectrum of the sample; and a second spectrum acquisition means configured to acquire an infrared absorption spectrum of the sample, based on a change in the spectrum of the incident light with respect to a change in a wavelength by the light source controller during the probe-light and pump-light emission to the sample. | 2021-12-09 |
20210381977 | BIOSENSORS FOR BIOLOGICAL OR CHEMICAL ANALYSIS AND METHODS OF MANUFACTURING THE SAME - Biosensor including a device base having a sensor array of light sensors and a guide array of light guides. The light guides have input regions that are configured to receive excitation light and light emissions generated by biological or chemical substances. The light guides extend into the device base toward corresponding light sensors and have a filter material. The device base includes device circuitry electrically coupled to the light sensors and configured to transmit data signals. A passivation layer extends over the device base and forms an array of reaction recesses above the light guides. The biosensor also includes peripheral crosstalk shields that at least partially surround corresponding light guides of the guide array to reduce optical crosstalk between adjacent light sensors. | 2021-12-09 |
20210381978 | METHOD FOR DETECTING SILICA - The present invention relates to utilization of lanthanide time resolved fluorescence for determining silica concentration. In the method sample comprising silica is admixed with a reagent comprising a lanthanide (III) ion and optionally a chelating agent, silica in the sample is allowed to interact with the reagent comprising the lanthanide (III) ion, followed by exciting the sample and detecting a signal deriving from the lanthanide (III) ion, and determining the concentration of the silica in the sample by using the detected signal. | 2021-12-09 |
20210381979 | APPARATUS AND METHOD FOR MULTIPLEXED ROTATING IMAGING BIOASSAYS - Systems and method for versatile multiplexed spinning/rotating bioassays are provided. This bioassay platform can take the advantage of the high-speed spinning motion, which naturally provides on-the-fly cellular imaging at the rate that cannot be reached by the conventional cameras or laser-scanning techniques, but ultrafast imaging modalities. More importantly, the functionalized solid substrates derived from the disk substrate can be compatible with adherent cell culture as well as biochemically-specific cell-capture, which can now be assayed with ultrafast imaging modalities at an ultra-high-speed line-scan rate of >10 MHz. Large-format spinning high-throughput imaging assay could thus be a potent tool for scaling both the assay throughput as well as content/multiplexity as demanded in many applications, e.g. drug discovery, and rare cancer cell screening. | 2021-12-09 |
20210381980 | Multicolor Fluorescence Reader with Dual Excitation Channels - Provided is a fluorescence reader that uses two excitation channels and can read up to seven different fluorescent dyes in a single run. Each excitation channel has one light source and one single excitation filter and one dichroic mirror. One excitation channel is capable of exciting multiple fluorescent dyes and can be used to distinguish multiple dyes in combination with multiple emission filters. The excitation channels are driven by a motor that can automatically switch the two excitation channels for taking images of up to seven different fluorescent dyes. An algorithm to calibrate the crosstalk between different fluorescent dyes is also provided. Also provided is a method for analyzing digital PCR data using a ratio of two fluorescence emission readings. | 2021-12-09 |
20210381981 | GAS SENSOR ELEMENT AND GAS DETECTION DEVICE FORMED FROM THE SAME - A gas sensor element includes: a supporting base material; a first light-emitting layer that is provided on the supporting base material and contains a first light-emitting particle which emits light at a first peak wavelength; a sensor layer that is provided on the first light-emitting layer and adsorbs gas molecules; a second light-emitting layer that is provided on the sensor layer and contains a second light-emitting particle which emits light at a second peak wavelength different from the first peak wavelength; and a protective layer that is provided on the second light-emitting layer, in which the gas sensor element has a laminated structure in which the supporting base material, the first light-emitting layer, the sensor layer, the second light-emitting layer, and the protective layer are laminated in this order, and the laminated structure includes an opening that penetrates a part or entirety of the laminated structure. | 2021-12-09 |
20210381982 | Medium For Resin Particles Containing Fluorescent Dye - An object of the present invention is to provide a medium which is capable of inhibiting precipitation and/or aggregation of fluorescent dye-containing resin particles and enables to use the fluorescent dye-containing resin particles for staining after a long-term storage without having to perform complicated operations. The present invention provides a medium for storing fluorescent dye-containing resin particles, wherein, in a particle-containing liquid obtained by adding fluorescent dye-containing resin particles to the medium, the rate of change in the backscatter intensity (transmitted light) at the center of the height of the particle-containing liquid left to stand for 24 hours after the addition is not less than −1% based on the particle-containing liquid immediately after the addition. | 2021-12-09 |
20210381983 | Methods for Performing a Raman Spectroscopy Measurement on a Sample and Raman Spectroscopy Systems - There is described a method for performing a Raman spectroscopy measurement on a sample. The method generally has sequentially illuminating an area of said sample with first and second excitation signals, said first excitation signal being slightly spectrally spaced-apart from said second excitation signal, resulting in said area sequentially emitting first and second emission signals; upon receiving said first emission signal, measuring a first intensity value being indicative of optical intensity of said first emission signal within at least a detection band; upon receiving said second emission signal, measuring a second intensity value being indicative of optical intensity of said second emission signal within said detection band; and performing said Raman spectroscopy measurement by comparing said first intensity value to said second intensity value. | 2021-12-09 |
20210381984 | pH Responsive Optical Nanoprobe - There is provided a pH responsive optical nanoprobe comprising metallic SWCNTs or graphene coated with a transition metal M. The coated metallic SWCNTs or graphene have an absorption spectrum comprising an optical resonance, and have a Raman scattering spectrum responsive to optical excitation at said optical resonance comprising at least one pH-dependent peak having at least one of a Raman shift value and an intensity that is function of a solution pH, when the nanoprobe is in contact with a solution at said solution pH. There is also provided a method to measure the pH of a solution, by contacting the solution with the nanoprobe; illuminating the nanoprobe with an excitation light beam having a wavelength at said optical resonance, thereby generating a Raman signal from the nanoprobe according to said Raman scattering spectrum; measuring a spectral distribution of the Raman signal; and determining the pH of the solution from the spectral distribution. | 2021-12-09 |
20210381985 | METHODS AND DEVICES FOR DETECTING A STIMULATED-RAMAN-SCATTERING (SRS) SIGNAL IN A SAMPLE - According to one aspect, the present description relates to a device for detecting an SRS resonant non-linear optical signal induced in a sample. The device comprises a light source configured for emitting a first train of pump pulses at a first angular frequency and a second train of Stokes pulses at a Stokes second angular frequency, and first and second amplitude modulators configured to amplitude modulate the train of pump pulses at a first modulation frequency and the train of Stokes pulses at a second modulation frequency different from the first modulation frequency, respectively. The device further comprises optomechanical means for making interact in the sample said amplitude-modulated trains of pump and Stokes pulses, means for optical detection of first and second non-linear optical signals at the first angular frequency and second angular frequency, respectively, and means of synchronous detection of the first and second optical signals at said second modulation frequency and at the first modulation frequency, respectively, allowing an SRL first signal and an SRG second signal that are characteristic of the molecular vibrational resonance of the sample to be extracted. | 2021-12-09 |
20210381986 | TOTAL INTERNAL REFLECTION ENABLED WIDE-FIELD COHERENT ANTI-STOKES RAMAN SCATTERING MICROSCOPY - A system is provided. The system has a femtosecond oscillator to generate pulses used for pump and probe beams. A photonic crystal fiber is disposed in a path of the probe beam and produces pulses for a chirped probe beam. A high NA objective receives the pump and the chirped probe beam, redirects the received beams through a dielectric substrate towards an interface between a sample and the dielectric substrate to cause total internal reflection (TIR) at the sample-substrate interface, and produces corresponding evanescent waves in a portion of the sample adjacent to the sample-substrate interface, and collects a backward-propagating beam of pulses of responsive light. The portion of the sample illuminated by the evanescent waves emits responsive light. The dielectric substrate is transparent to the responsive light, the pump and the chirped probe beam. An image is produced having a specific image size using the received backward-propagating beam. | 2021-12-09 |
20210381987 | BRANCHED-CHAIN AMINES IN ELECTROCHEMILUMINESCENCE DETECTION - The disclosure concerns methods for the detection of an analyte in a sample by electro-chemiluminescence using new reagent compositions. New reagent compositions, reagent kits for measuring electrochemiluminscence (ECL) and electrochemiluminescence detection methods using the new reagent compositions are disclosed. In particular, the disclosure relates to the use of novel combinations of compounds which can be used in said measurements to provide improved assay performance. | 2021-12-09 |
20210381988 | METHOD AND DEVICE FOR DETECTING PYRETHROID PESTICIDE RESIDUES IN CROPS - A method and device for detecting pyrethroid pesticide residues in crops. Reaction membrane is arranged on a bottom plate and provided with a check-up line and a quality control line; a first mounting block and a second mounting block are arranged on the bottom plate; a first slide is arranged in the first mounting block, a second slide is arranged in the second mounting block; a sample pad and a bonding pad are arranged in the first slide; a water absorption pad is arranged in the second slide; a liquid inlet provided with a pipe is formed in the first mounting block, a pressing hole provided with a press block is formed in the second mounting block; protrusions are respectively formed on the pipe and the press block; sliding grooves are formed in the liquid inlet and the pressing hole; and first springs are arranged between the protrusions and the sliding grooves. | 2021-12-09 |
20210381989 | Defect Inspection Device and Defect Inspection Method - The purpose of this invention is to make it possible to efficiently and accurately detect a reticle defect at an earlier stage in a manufacturing process. The inspection device according to this invention uses the results of comparing die images of wafers that have had patterns transferred thereto using the same reticle after subjecting the die images to averaging processing and the results of comparing the die images without subjecting the same to averaging processing to distinguish a random defect signal caused by a huge defect, or the like, and having an extremely high brightness from a repeated defect signal, and only extracts repeated defects with higher accuracy. | 2021-12-09 |
20210381990 | VISUAL INSPECTION DEVICE - A visual inspection device including a pinhole lens optically coupled to a sensor is provided. The pinhole lens has a pinhole placed at the distal end of the lens to capture the rays from an object to be inspected, a front optical group receiving the rays which cross the pinhole, and a rear optical group. The front optical group is configured to focus, on the rear optical group, the rays which cross the pinhole. The rear optical group is configured to focus, on the sensor, the rays received from the front optical group. | 2021-12-09 |
20210381991 | TRAY INSERT FOR SCREENING TRAY - An article for screening includes a top surface and a bottom surface. A forward wall, an aft wall and side walls each extend between the top surface and the bottom surface. A longitudinal recess extends at least partially across the top surface has a first lateral wall extending away from the top surface toward the bottom surface and meeting with a base wall at a predetermined angle therebetween for positioning of a liquid material relative to the first lateral wall and the base wall. The predetermined angle is for restricting data in a data range provided by a scanning operation of the liquid material to data provided within the predetermined angle between the first lateral wall and the base wall of the recess. The liquid material may be contained within a container positioned within the recess. Preferably, the article is an insert for a security screening tray. | 2021-12-09 |
20210381992 | HYPERDIMENSIONAL SCANNING TRANSMISSION ELECTRON MICROSCOPY AND EXAMINATIONS AND RELATED SYSTEMS, METHODS, AND DEVICES - A material identification system includes one or more data interfaces configured to receive first sensor data generated by a first sensor responsive to a material sample, and receive second sensor data generated by a second sensor responsive to the material sample. The material identification system also includes one or more processors configured to generate a set of predictions of an identification of the material sample and a corresponding set of certainty information. | 2021-12-09 |
20210381993 | METHOD TO DETERMINE PORE SIZE DISTRIBUTION OF ROCKS WITH ROUGH SURFACE FROM CAPILLARY PRESSURE BY NUCLEAR MAGNETIC RESONANCE - A method for determining pore size distribution of rocks is provided. Capillary pressure measurements on rock cores are analyzed to determine a pore size distribution, with smaller pores requiring greater capillary pressure to relinquish contained fluid. Large pores with rough surfaces introduce inaccuracies in determining the pore size distribution. Embodiments of the invention correct the rough surface induced inaccuracies by measuring the shift in NMR T2 distribution from full saturation to the current state of desaturation and subtracting the T2 contributions in the desaturated state that have smaller T2 values (i.e., smaller transverse relaxation time) than the smallest T2 values (i.e., shortest transverse relaxation time) in the saturated distribution. | 2021-12-09 |
20210381994 | Methods and Systems of Fabricating Electrical Devices by Micro-Molding - Systems of electrical devices with high-resolution components and methods of fabricating the electrical devices using micro-molding processes are described. Small foot print electrical devices can be achieved by fabricating components with highly conductive materials, and with closely spaced components. | 2021-12-09 |
20210381995 | CERAMIC SMART IMPACT PANEL - An impact panel for protecting mining equipment may include a plurality of ceramic tiles affixed to a base plate. The impact panel may further include at least one fixing hole disposed within the plurality of ceramic tiles and the base plate with a metal frame disposed around an outer peripheral edge of the plurality of ceramic tiles that is also affixed to the base plate. The impact panel may have at least one plug disposed inside the at least one fixing hole to seamlessly cover the at least one fixing hole. The panels may also be wired with sensors that will communicate with process control circuits allowing data collection on remote process and remote mining equipment | 2021-12-09 |
20210381996 | CRACK SENSOR SYSTEM - The present invention comprises: crack detection wiring ( | 2021-12-09 |
20210381997 | ELECTRIC FIELD-ASSISTED JUNCTIONS FOR SEQUENCING - Molecules may be analyzed (e.g., sequencing of nucleic acid molecules) by tunneling recognition at a tunneling junction. Embodiments of the present invention may allow detecting individual nucleotides and the sequencing of a nucleic acid molecule using a tunneling junction. By labeling a specific 5 nucleotide with a moiety, tunneling junctions may generate a signal with a suitable signal-to-noise ratio. An electric field may be applied to move the nucleic acid molecule and the moiety close to the tunneling junction so that a current may travel through the moiety. Because a single nucleotide can be detected with a signal with a suitable signal-to-noise ratio resulting from the tunneling current passing through 10 the moiety, embodiments of the present invention may allow for fast detection of nucleotides using a tunneling current. | 2021-12-09 |
20210381998 | METHOD FOR DETERMINING ANALYTE CONCENTRATION IN A SAMPLE TECHNICAL FIELD - A method for determining a concentration of an analyte in a fluidic sample is described. A sample is applied to a biosensor including an electrochemical cell having electrodes. A predetermined voltage waveform is applied during at least first and second time intervals. At least first and second current values are measured during the first and second time intervals, respectively. A turning point time is determined during the first time interval at which the measured first current values transition from a first to a second profile. The concentration of analyte in the sample is calculated based on determined turning point time and at least one measured current value. In another example, a physical characteristic of the sample is estimated based on measured current values. The concentration is calculated using a first or second model if the estimated physical characteristic of the sample is in a first or second range, respectively. | 2021-12-09 |
20210381999 | SENSOR ELEMENT AND GAS SENSOR - A sensor element includes an element body having a measurement-object gas flow section formed therein, and a porous protective layer arranged to cover first to fifth surfaces of the element body. When an external wall that is the thinnest of parts of an external wall which constitute the element body and extend from the measurement-object gas flow section to the first to fifth surfaces is defined as a thinnest external wall and a surface corresponding to the thinnest external wall is defined as a closest surface, a part of the protective layer which covers the closest surface overlaps the entirety of the thinnest external wall when viewed in a direction perpendicular to the closest surface, and has one or more internal spaces formed therein which overlaps 80% or more of the thinnest external wall when viewed in the direction perpendicular to the closest surface. | 2021-12-09 |
20210382000 | AUTOMATED ANALYZER, AUTOMATIC ANALYSIS SYSTEM, AND AUTOMATIC SAMPLE ANALYSIS METHOD - An analysis unit | 2021-12-09 |
20210382001 | QUANTITATIVE MEASUREMENT OF MEMBRANE PROTEIN FUNCTION ON A BIOSENSOR - Disclosed herein are methods and devices for a cell-free assay platform that enables measurement of membrane protein function by measuring the events that are induced by ligand binding or other stimuli. | 2021-12-09 |
20210382002 | DETECTION METHODS FOR EPITACHOPHORESIS WORKFLOW AUTOMATION - The present disclosure generally relates to systems comprising devices for effecting epitachophoresis and sample detection and methods of using such systems. Epitachophoresis may be used to effect sample analysis, such as by selective separation, detection, extraction, and/or pre-concentration of target analytes such as, for example, DNA, RNA, and/or other biological molecules. Sample detection may be used to trigger automated target analyte collection. Said target analytes may be used for desired downstream applications and further analysis. | 2021-12-09 |
20210382003 | Method and System for Simultaneous Determination of Multiple Measurable Biomarkers During the Development of a Communicable Disease - A diagnostic and prognostic method and system for sequentially analyzing in a biological fluid or tissue extract the presence of an antigenic infectious agent, infectious organism or its toxic product; an antibody response to the antigenic infectious agent, infectious organism or its toxic product; one or more biomarkers formed during infection in response to a communicable disease; and one or more biomarkers to assess the severity of the disease and to monitor the effectiveness of drug therapy or vaccination. | 2021-12-09 |
20210382004 | Capillary Electrophoresis Apparatus - A capillary electrophoresis apparatus is disclosed that does not discharge and achieves both compactness and performance even with a part configuration having insufficient spatial distance or creeping distance. This capillary electrophoresis apparatus is provided with a resistance heater for heating capillaries, an electrode holder that holds capillary electrodes and is connected to a high-voltage unit, and a conductive member that at least partially comprises metal and has been grounded to a low potential. The electrode holder and conductive member are in contact with heat-dissipating rubber disposed there between that composes a structure comprising an insulation member. As a result of this configuration, discharge risk is reduced through the reduction of the potential of parts near the high-voltage unit and the slow reduction of the high potential of the high-voltage unit. | 2021-12-09 |
20210382005 | ION DETECTOR - A dual-mode ion detector for a mass and/or ion mobility spectrometer comprising a first conversion electrode ( | 2021-12-09 |
20210382006 | Apparatus and Methods for Ion Manipulation Having Improved Duty Cycle - An apparatus for ion manipulation having improved duty cycle includes first and second separation regions separated by a switch that alternates between guiding ions to each of the separation regions. The separation regions separate the ions based on mobility over respective time periods that at least partially overlap. The apparatus can additionally or alternatively include a pre-separation region that filters ions prior to accumulating ions, thus allowing an accumulation region to accumulate for a longer time period. The apparatus can additionally or alternatively include a plurality of gates along the separation region(s) to simultaneously filter a plurality of ion packets sequentially released into the separation region(s). Methods for ion manipulation having improved duty cycle involve separating ions on two separation regions over first and second time periods that at least partially overlap, pre-filtering ions prior to accumulation and separation, and/or simultaneously filtering a plurality of ions packets are also provided. | 2021-12-09 |
20210382007 | NON-DESTRUCTIVE TESTING DEVICE FOR DETECTING DAMAGE TO STEEL WIRE ROPE - A non-destructive testing device for detecting damage to a steel wire rope, including a bushing which limits a lower shell and an upper shell through a limiting groove. The lower shell is connected to the upper shell via an opening and closing structure. An air bag is wrapped around the bushing. A PCB is fixed on the upper shell or the lower shell. The PCB is connected to a guide wheel via an electrical connector. A magnetoresistive sensor array is arranged inside the air bag and is uniformly arranged in a circumferential direction of the bushing. A steel wire rope passes through the magnetoresistive sensor array. And when the steel wire rope moves, it drives the guide wheel to rotate and triggers the acquisition of a command. Guide wheel is set with a position coder which is used to calculate a relative position of movement of the steel wire rope. The PCB is connected to a single chip microcomputer via a peripheral interface. And the single chip microcomputer is used to calculate a differential signal of N adjacent magnetoresistive sensors and to determine whether the steel wire rope is damaged. The capability of this non-destructive testing device for detection of a broken wire, a narrowed diameter, and deep damage of the steel wire rope is improved. | 2021-12-09 |
20210382008 | MAGNETIC BODY MANAGEMENT SYSTEM AND MAGNETIC BODY MANAGEMENT METHOD - This magnetic body management system ( | 2021-12-09 |
20210382009 | DAMAGE DETECTION METHOD OF WIRE ROPE, AND SIGNAL PROCESSOR AND DAMAGE DETECTION DEVICE USED FOR DAMAGE DETECTION OF WIRE ROPE - A magnetic detector includes permanent magnets that magnetize a wire rope W in the longitudinal direction, and a search coil that detects a change in the cross sectional area of the wire rope W magnetized by the permanent magnets. The magnetic detector is provided so as to surround a part of the wire rope W. Prior to inspection, the magnetic detector is moved back and forth at least three times across an inspection range of the wire rope W. After the magnetic detector is moved back and forth, the change in the cross sectional area, that is, damage to the wire rope W is inspected by using signals outputted from the search coil. | 2021-12-09 |
20210382010 | NON-CONTACT SPEED ENCODER - An eddy current (EC) detection system comprises an EC probe including a plurality of sensors to provide corresponding EC response signals; and processing circuitry to evaluate speed of the EC probe based on a measurement of similarity of the EC response signals; determine whether the speed of the EC probe is too fast or two slow based on quality of the measurement; and generate a command to adjust speed of the EC probe during further EC the inspection. | 2021-12-09 |
20210382011 | Sensor with Droplet Retaining Structure - This disclosure describes methods and devices that assist in forming biosensors. Specifically, features that align solutions containing molecules to be immobilized on biosensors. A retaining structure may be disposed at least partially around a target surface of a substrate. A resonating structure may be disposed on the target surface. A droplet of functionalized material may be disposed on the resonating structure and the target surface, which may be auto-aligned and retained by the retaining structure on the target surface to consistently cover the resonating structure. | 2021-12-09 |
20210382012 | ULTRASONIC DEVICE - The present disclosure relates to an ultrasonic device for real-time and nondestructive assessment of extracellular matrix stiffness, and the method of making and using the novel ultrasonic device. | 2021-12-09 |
20210382013 | Photo-Acoustic Tomography Defect Testing System And Method - A part defect testing system includes a hammer beam system that provides laser light having a first wavelength. A read-out beam system provides laser light having a second wavelength. A control system is used to direct the generated hammer beam laser light toward a first position on a part to provide an acoustic hammer pulse that induces surface movement of the part. An areal camera is arranged to produce an interferogram derived from reading surface movement of the part using the read-out beam directed to a second position on the part. | 2021-12-09 |
20210382014 | ULTRASONIC MONITORING PROBE FOR INTERNAL SERVICE STRESS OF A MARINE STRUCTURAL COMPONENT - An ultrasonic monitoring probe for internal service stress of a marine structural component. The probe includes a detection wedge provided with two symmetrically arranged inclined surfaces at its top, two connecting channels vertical to the two inclined surfaces and penetrating through the detection wedge and provided with threaded holes close to the inclined surfaces and water storage cavities far away from the inclined surfaces, two ultrasonic transducers mounted in the threaded holes of the two connecting channels and configured for generating and receiving ultrasonic waves; two bottom rings located at a bottom of the detection wedge and arranged relative to the water storage cavities and configured for attachment to a surface of a detected component, a magnet disposed in a magnet placement hole arranged at a central position between the two connecting passages, and a monitoring device electrically connected with the two ultrasonic transducers. | 2021-12-09 |
20210382015 | DEAD ZONE INSPECTION WITH ULTRASONIC TESTING USING SIGNAL INTEGRATION - An ultrasonic inspection system, method, and software. In one embodiment, the ultrasonic inspection system includes an ultrasonic probe that directs ultrasound waves into a structure from a front wall, and receives reflected waves to generate a response signal. The system further includes a processor that rectifies the response signal to generate a rectified signal, integrates a portion of the rectified signal within a detection time window to determine an energy sum, and generates output based on the energy sum. The detection time window is restricted to a front wall reflection and at least a portion of a near-surface dead zone following the front wall reflection. | 2021-12-09 |
20210382016 | DIGITAL TWIN MODEL INVERSION FOR TESTING - Creation and use of a digital twin instance (DTI) for a physical instance of the part. The DTI may be created by a model inversion process such that model parameters are iterated until a convergence criterion related to a physical resonance inspection result and a digital resonance inspection result is satisfied. The DTI may then be used in relation to part evaluation including through simulated use of the part. The physical instance of the part may be evaluated by way of the DTI or the DTI may be used to generate maintenance schedules specific to the physical instance of the part. | 2021-12-09 |
20210382017 | Thermal Modulator - A thermal modulator for a chromatographic system includes a cooler, a thermal valve, a thermal buffer, a heater, and a capillary. The thermal valve thermally-engages the cooler. The thermal buffer thermally-engages the thermal valve. The heater thermally-engages the thermal buffer. The capillary thermally-engages the heater and is configured to transport an analyte in a first direction. | 2021-12-09 |
20210382018 | FLOW PASSAGE SWITCHING VALVE AND LIQUID CHROMATOGRAPH HAVING THE SAME - A liquid chromatograph has a long-life flow passage switching valve with reduced abrasion caused by sliding of flow passage end portions of a stator and flow passage end portions of a rotor seal. The flow passage switching valve includes: a stator; and a rotor seal connected with a rotor configured to rotate and slide on a circumference with respect to the stator. The stator has stator flow passages that open to the rotor seal. The rotor seal has a rotor seal flow passage for coupling two or more of the stator flow passages. A flow passage end portion that is positioned at a tip end in a sliding direction of the rotor seal flow passage is positioned in a direction opposite to the sliding direction of the stator flow passage end portion to be connected to the rotor seal flow passage, at least at the start of sliding. | 2021-12-09 |
20210382019 | System and valve for liquid chromatography - Systems for use with liquid chromatography for provision of continuous flow or gradient flow in connection with two pumps providing mobile phase to a valve. | 2021-12-09 |
20210382020 | CHROMATOGRAPHIC CONTROL DEVICE, CHROMATOGRAPHIC SYSTEM, CHROMATOGRAPHIC CONTROL METHOD AND CHROMATOGRAPHIC CONTROL PROGRAM - A range of pH of a mobile phase that is usable for an analysis with use of each column is registered by a pH range registrar in association with identification information of each column. A pH of each mobile phase is registered by a pH registrar. A column to be used for an analysis is selected by a column selector. A chromatograph is controlled by an analysis controller such that a mobile phase having a registered pH that is out of a range of pH that is registered in association with a selected column is not supplied to the selected column. The chromatograph is controlled by the analysis controller such that an analysis is performed while a mobile phase having a registered pH that is in a range of pH that is registered in association with a selected column is supplied to the selected column. | 2021-12-09 |
20210382021 | SYSTEMS AND METHODS FOR TWO-DIMENSIONAL LIQUID CHROMATOGRAPHY USING SIZE EXCLUSION CHROMATOGRAPHY AS A FIRST DIMENSION - Described herein are systems and methods used for carrying out a two-dimensional liquid chromatography process using size exclusion chromatography as a first dimension. | 2021-12-09 |
20210382022 | SYSTEM FOR COLLECTING LIQUID SAMPLES - Systems and methods are described to determine whether a sample transmitted through a transfer line from a remote sampling system contains a suitable sample to analyze by an analysis system. A system embodiment includes, but is not limited to, a sample receiving line configured to receive a liquid segment a first detector configured to detect the liquid segment at a first location in the sample receiving line; a second detector configured to detect the liquid segment at a second location in the sample receiving line downstream from the first location; and a controller configured to register a continuous liquid segment in the sample receiving line when the first detector and the second detector match detection states prior to the controller registering a change of state of the first detector. | 2021-12-09 |
20210382023 | AUTOMATED ONLINE CHROMATOGRAPHIC SAMPLE DILUTION & PREPARATION SYSTEM - The present disclosure relates to a computer-implemented method for analyzing a product stream of a chemical reaction. The method includes withdrawing a portion of the product stream of the chemical reaction from a reactor, the portion of the product stream having a volume of less than about 200 μL. The method further includes mixing the portion of the product stream with a diluent to produce a sample and then transferring the sample to a liquid chromatography device. A measured chemical profile is then developed, via the liquid chromatography device, which can be used for process monitoring or real time decision making. In some embodiments, the method can include adjusting a reaction condition in the reactor based on differences between the measured chemical profile and a desired chemical profile. | 2021-12-09 |
20210382024 | Sensor Arrangement and Method for Sensing an Amount or a Concentration of a Target Fluid in a Medium with the Sensor Arrangement - According to an embodiment, a sensor arrangement comprises a first micropump, e.g. a microfluidic or peristaltic pump, having a normally closed (NC) safety valve, e.g. at the micropump output, a second micropump, e.g. microfluidic or peristaltic pump, having a normally closed (NC) safety valve, e.g. at the micropump output, and a sensor having a sensor chamber, e.g. a sensor cavity or sensor volume, with a sensor element, e.g. an active sensitive region or layer, in the sensor chamber, wherein the sensor is configured to provide a sensor output signal based on a condition of the fluid, e.g. a gas or liquid, in the sensor chamber. The sensor chamber of the sensor is fluidically coupled between the first and second micropump, and the first and second micropump are configured to provide a defined operation mode of the sensor arrangement based on the respective activation or operation condition of the first and second micropump for providing (1.) a defined negative fluid pressure in the sensor chamber, (2.) a defined positive fluid pressure in the sensor chamber or (3.) a defined fluid flow, e.g. fluid throughput, through the sensor chamber. | 2021-12-09 |
20210382025 | HANDHELD DEVICE USING A LIGHT GUIDE AND METHOD FOR USE THEREOF FOR DETERMINING A PLANT STATUS - The invention relates to a handheld device and method for determining a status of a plant. The device includes a multi pixel digital colour sensor, a light source arranged for providing broadband illumination, wherein the light source and the multi pixel digital colour sensor are arranged in substantially the same plane, a light guide for guiding the light from said light source into the direction of the multi pixel digital colour sensor, a sample space, provided between the multi pixel digital colour sensor and the light source, for insertion of at least a part of the plant therein, and a processing unit configured for controlling at least the multi pixel digital colour sensor and the light source. | 2021-12-09 |
20210382026 | APPARATUS FOR MICROBIAL ACTIVITY DETECTION AND INVENTORY MANAGEMENT, AND PROCESS THEREOF - A system and method for the real time determination of microbial growth in or on perishable products. The system can predict the extent of microbial growth, e.g., whether food is spoiled, in real time by measuring chemicals released, e.g., CO | 2021-12-09 |
20210382027 | SYSTEM AND METHOD FOR MEASUREMENT OF CONTAINER CONTENT QUANTITY AND ANALYSIS OF SAME - A system and method are disclosed for quantity analysis. A quantity identification of an amount of content included in a container is received from a container cover of the container. The quantity identification is analyzed along with a history of past quantity identifications received from the container cover over time to determine an analysis result. An action associated with the content of the container is performed based on the analysis result. A system and method are disclosed that include one or more devices that help users track remaining quantity and expiration of food (e.g., including beverages). | 2021-12-09 |
20210382028 | MEANS AND METHODS FOR DETECTING SOY ALLERGENS - The present invention relates to the field of antibodies and their application in food and feedstuff quality control. In particular, the invention relates to a method for the manufacture of an antibody that specifically binds to soy Gly m 8 protein wherein said method comprises immunising an animal with the purified soy Glym8 protein, wherein said soy Glym8 protein has been obtained by expressing soy Glym8 protein in plants, and preferably, tobacco plants and purifying the soy Glym8 protein from said plants and, preferably, tobacco plants and obtaining an antibody from the animal which specifically bind to soy Gly m8 protein, wherein the animal will be sacrificed. Moreover, the invention contemplates an antibody obtained by said method as well as the use of said antibody for detecting soy material in a food preparation or feedstuff preparation. Further, a method for detecting soy material in a food preparation or feedstuff preparation and a kit for carrying out said method are provided. | 2021-12-09 |
20210382029 | METHOD FOR SCREENING EOR AGENTS EFFECTS ON RESERVOIR ROCK WETTABILITY: AN IN-SITU CONTACT ANGLE MEASUREMENT - A method for determining a contact angle of a hydrocarbon on a rock surface, the method including injecting a first brine fluid into a test cell, the first brine fluid having an initial ionic composition, injecting a hydrocarbon fluid into the test cell, contacting the hydrocarbon fluid with the first brine fluid, forming a droplet, measuring the contact angle of the hydrocarbon fluid, at least partially displacing the first brine fluid with an inert gas, measuring a ionic composition of the displaced first brine fluid in an ionic chromatograph, and comparing the measured ionic composition to the initial ionic composition. | 2021-12-09 |
20210382030 | HYDROCARBON CONDENSATE DETECTION AND CONTROL - Hydrocarbon condensate detection and control. The hydrocarbon condensate detection and control system includes detecting hydrocarbon in an aqueous mixture by sensing fluorescence, turbidity, and color of the aqueous mixture and controlling the flow of the aqueous mixture based on the hydrocarbon content of the aqueous mixture. | 2021-12-09 |
20210382031 | DETECTION DEVICE - A detection device that is capable of being attached to a through hole includes a main body portion, a detection portion, a cover portion, an insulation portion, and an oscillation portion. The main body portion has an insertion portion and a head portion. The detection portion is arranged in the insertion portion and detects the state of a fluid. The cover portion is arranged so as to form a gap with the head portion. The insulating portion has a lateral wall having a cylindrical shape. An oscillation portion is accommodated inside the insulation portion, and performs a wireless output of a detection result of the detection portion by using the head portion, the cover portion and the gap as a slot antenna. | 2021-12-09 |
20210382032 | EMBEDDED WIRELESS MONITORING SENSORS - Concrete can be one of the most durable building materials where consumption is projected to reach approximately 40 billion tons in 2017 alone. Despite this the testing of concrete at all stages of its life cycle is still in its infancy although testing for corrosion is well established. Further many of the tests today are time consuming, expensive, and provide results only after it has been poured and set. Accordingly, by exploiting self-contained wireless sensor devices, which are deployed with the wet concrete, the in-situ curing and maturity measurement data can be established and employed together with batch specific concrete data to provide rapid initial tests and evolving performance data regarding the concrete cure, performance, corrosion of concrete at different points in its life cycle. Such sensors remove subjectivity, allow for rapid assessment, are integrable to the construction process, and provided full life cycle assessment. | 2021-12-09 |
20210382033 | Single Molecule Proteomics - This disclosure comprises devices and methods for determining the identity of individual protein molecules in a complex mixture by unfolding the protein into a polypeptide, tagging selected residues on the polypeptide with selected oligonucleotide sequence tags that recognize selected residues on said polypeptide, and then detecting the oligonucleotide sequence tags. | 2021-12-09 |
20210382034 | NANOPORE DEVICE AND METHOD OF MANUFACTURING SAME - A 3D nanopore device for characterizing biopolymer molecules includes a first selecting layer having a first axis of selection. The device also includes a second selecting layer disposed adjacent the first selecting layer and having a second axis of selection orthogonal to the first axis of selection. The device further includes an third electrode layer disposed adjacent the second selecting layer, such that the first selecting layer, the second selecting layer, and the third electrode layer form a stack of layers along a Z axis and define a plurality of nanopore pillars. | 2021-12-09 |
20210382035 | PRETREATMENT OF BLOOD FOR CLASSIFYING BLOOD CELLS USING MICROCHANNEL - Blood containing cells is brought into contact with a porous surface of a porous material before classification of the cells in the blood by flowing the blood through a microchannel. In an example, the porous material is added to the blood containing the cells and mixed together, thereby bringing the blood containing the cells into contact with the porous surface. In an example, the porous material has particles with the porous surface including polysaccharides. The porous material is added to the blood containing the cells while being suspended in a liquid. In an example, the particles have a predetermined particle size distribution. A median particle size d | 2021-12-09 |
20210382036 | PLATELET AGGREGATION CAPACITY ANALYZER, PLATELET AGGREGATION CAPACITY ANALYSIS METHOD, AND PLATELET AGGREGATION CAPACITY ANALYSIS SYSTEM - To provide a new technology for measuring the aggregation capacity of platelets. Provided is, for instance, a platelet aggregation capacity analyzer including a blood coagulation system-analyzing unit configured to analyze a platelet aggregation capacity on the basis of measurement data during a coagulation process of a platelet-containing sample, and an output control unit configured to control an output of results analyzed by the blood coagulation system-analyzing unit, in which the blood coagulation system-analyzing unit analyzes the platelet aggregation capacity of the platelet-containing sample on the basis of measurement data during a coagulation process with a platelet aggregation inhibitor added to the platelet-containing sample and measurement data during a coagulation process without a platelet agonist or the platelet aggregation inhibitor added to the platelet-containing sample. | 2021-12-09 |
20210382037 | IDENTIFICATION AND USE OF CYTOTOXIC T LYMPHOCYTE (CTL) ANTIGEN-SPECIFIC TARGET CELL KILLING ENHANCER AGENTS - The present invention relates to screening methods for identification of agents (e.g., small molecules) that modulate cytotoxic T lymphocyte antigen-specific target (e.g., tumor) cell killing, as well as to uses of compounds identified thereby as immunomodulatory, including use of EGFR inhibitors as immunomodulatory agents. | 2021-12-09 |
20210382038 | METHOD FOR IDENTIFYING MODULATORS OF NOTCH SIGNALING - The present invention relates to use of inhibitors of Notch signalling pathway selected from the group consisting of 6-(4-Tert-Butylphenoxy)Pyridin-3-Amine (I3), its derivatives, in treating and/or preventing cancers. | 2021-12-09 |
20210382039 | METHOD FOR ASSESSING THE ABILITY OF A SUBSTANCE OR OF A COMPOSITION TO PREVENT, SLOW OR ELIMINATE THE SIGNS OF AGEING OF THE SKIN OR OF THE LIPS - A method for assessing the ability of a chemical substance or of a chemical composition to prevent or to slow the appearance of signs of aging of the human skin or of the lips or even to eliminate the signs; the method including: —a step a) of bringing the chemical substance or the chemical composition into contact with fibroblast cells of the “young” human dermis taken from a culture medium at the passage R6; —a step b) of bringing senescent cells of fibroblasts of the human dermis into contact with the cells of “young” fibroblasts from step a); and—a step c) of measuring the senescence input of the cells of “young” fibroblasts and of comparing it with a reference value. | 2021-12-09 |
20210382040 | DETECTION OF BIOLOGICALS PENETRATION INTO TISSUE SURROGATES - Provided are methods of assessing penetration of biologicals into surrogate tissues. | 2021-12-09 |
20210382041 | IMMUNOASSAY AND MEASUREMENT REAGENT FOR LEUCINE-RICH ALPHA2 GLYCOPROTEIN - An object of the present invention is to provide a measurement method and a reagent for measurement which can measure LRG in a biological sample simply in a short time. The present inventors have intensively studied to achieve the object and made findings that LRG in a biological sample can be measured simply in a short time by an immunoagglutination measurement method in which the biological sample is brought into contact with insoluble carrier particles carrying a first anti-LRG monoclonal antibody and insoluble carrier particles carrying a second anti-LRG monoclonal antibody in a liquid phase, and the invention has been thus completed. | 2021-12-09 |
20210382042 | NANO-ENZYME CONTAINERS FOR TEST ELEMENTS - The present invention relates to a test element for the detection of an analyte comprising an enzyme, wherein the enzyme is incorporated in a nanocapsule. | 2021-12-09 |
20210382043 | METHODS FOR ISOLATING SURFACE MARKER DISPLAYING AGENTS - The invention relates to method and kits for highly specific isolation of surface marker displaying agents by targeting at least two surface markers. The invention further relates to methods and kits for analyzing surface marker displaying agents and their contents. | 2021-12-09 |
20210382044 | METHOD FOR DETERMINATION OF MEMBERS OF THE S100 FAMILY OF CALCIUM BINDING PROTEINS BY IMMUNOTURBIDIMETRY - A method for measuring the presence of calprotectin (S100A8/A) heterodimer in a biological sample using a particle-enhanced turbidimetric immunoassay (PETIA) based on monoclonal antibodies. The method can be adapted on automated standard analyzers and provides a reliable clinical measurement of calprotectin in faecal samples and extracts. The method is comparable to commerical two-site sandwich ELISA. The disclosed method counters spontaneous agglutination caused by calcium ions and low-molecular weight calcium-binding S100 proteins as observed with conventional PETIAs. The method can be used for measuring the presence of human calprotectin in stool, urine, serum, plasma, synovial liquid and other body liquids. Metrological traceability and high commutability with conventional immunoassays (ELISA) has been shown despite of different measurement principles used. | 2021-12-09 |
20210382045 | DYNAMIC EXCITATION AND MEASUREMENT OF BIOCHEMICAL INTERACTIONS - Apparatuses, systems, and methods are disclosed for excitation and measurement of biochemical interactions. Excitation circuitry is configured to apply one or more excitation conditions to a biologically gated transistor that includes a channel, so that one or more output signals from the biologically gated transistor are affected by the excitation condition(s) and by a biochemical interaction of moieties within a sample fluid in contact with the channel surface. Measurement circuitry is configured to obtain information corresponding to the biochemical interaction occurring at one or more measurement distances greater than an electrostatic screening distance from the surface of the channel, by performing a plurality of time-dependent measurements of affected output signals, using a measurement bandwidth that corresponds to the measurement distances. An analysis module is configured to characterize one or more parameters of the biochemical interaction based on the time-dependent measurements. | 2021-12-09 |
20210382046 | CHEMICALLY DIFFERENTIATED SENSOR ARRAY - Apparatuses, systems, and methods are disclosed for chemically differentiated sensor arrays and methods of manufacturing and using the same. In one or more examples. An integrated circuit chip includes a chemically differentiated array of graphene field effect transistors with one or more wells configured to receive a volume of biological sample liquid comprising a plurality of different types of biological substances to be distinguished using electrical measurements of output signals of the graphene field effect transistors. At least one electrode is configured to apply a changing gate bias voltage (V | 2021-12-09 |
20210382047 | APPARATUS - The present invention relates to a biochemical assay apparatus in which a sample processing device is controlled by a detection instrument through a series of linear and rotary actuations to execute a biochemical assay on a biological fluid sample. | 2021-12-09 |
20210382048 | DEVICES AND METHODS FOR THERAPEUTIC DRUG MONITORING - Devices and methods to perform a competitive immunoassay are disclosed. In some embodiments, the competitive immunoassay is for the detection of tacrolimus. The devices comprise a plurality of layers optionally made of cellulose-based material, wherein the plurality of layers comprises at least one read-out layer displaying a colorimetric readout of the device to indicate the result of the test to the user. | 2021-12-09 |
20210382049 | ASSESSING RESPONSIVENESS OF RHEUMATOID ARTHRITIS PATIENTS TO BIOLOGICAL TREATMENT - The relates to the field of diagnosis and treatment of Rheumatoid Arthritis, in particular of assessing responsiveness of rheumatoid arthritis patients to biological treatment. In particular the it has been found that measurement of MDR1 and/or MRP1 transport activities in the early phase of or before a bDMARD treatment is appropriate to provide a prediction on the effectiveness or success of bDMARD therapy once csDMARD therapy has failed. Thus, the invention relates to an in vitro diagnostic method for assessing the responsiveness of a sDMARD treated RA patient to bDMARD therapy, wherein preferably the patient is in need of a switch or modification of the sDMARD therapy by measuring transport activities of the above-mention transporters or their composite activities. The invention also relates to use of kits for the methods of the invention and methods for treatment comprising the diagnosis or prediction of the invention. | 2021-12-09 |
20210382050 | METHOD FOR MONITORING AUTOIMMUNE DISEASE - Provided herein are methods of monitoring progression, regression, or stage of an AID in a subject, measuring a level of expression of a gene, an RNA, or a protein, or a combination thereof, in a sample obtained from a niche at the implantation site of a synthetic scaffold in the subject at a first time point and at a second time point, wherein the expression level measured at the first time point is compared to the expression level measured at the second time point, wherein the difference in the level of expression at the second time point relative to the level of expression at the first time point is indicative of progression, regression, or stage of the autoimmune disease. Related methods of detecting an AID, determining treatment for a subject with an AID, determining efficacy of an AID treatment, or treating an AID, are further provided. | 2021-12-09 |
20210382051 | METHODS AND COMPOUND FOR THE IDENTIFICATION AND TREATMENT OF TUBERCULOSIS - A method to diagnose bacterial infection, including phenotyping cell based resistant mycoplasm, amplification and identification of infection, and performing at least one assay on a cell culture. | 2021-12-09 |
20210382052 | SERODIAGNOSTIC TESTING DEVICE AND SYSTEM FOR EARLY-STAGE LYME DISEASE USING A MULTIPLEXED IMMUNOASSAY - A multiplexed vertical flow serodiagnostic testing device for diseases such as Lyme disease includes one or more multi-piece cassettes that include vertical stacks of functionalized porous layers therein. A bottom piece of the cassette includes a sensing membrane with a plurality of spatially multiplexed immunoreaction spots or locations. Top pieces are used to deliver sample and/or buffer solutions along with antibody-conjugated nanoparticles for binding with the immunoreaction spots or locations. A colorimetric signal is generated by the nanoparticles captured on the sensing membrane containing disease-specific antigens. The sensing membrane is imaged by a cost-effective portable reader device. The images captured by the reader device are subject to image processing and analysis to generate positive (+) or negative (−) indication for the sample. A concentration of one or more biomarkers may also be generated. The testing device is rapid, simple, inexpensive, and allows for simultaneous measurement of multiple antibodies and/or antigens making it an ideal point-of-care platform for disease diagnosis. | 2021-12-09 |
20210382053 | COMPOSITIONS AND METHODS FOR DETECTING PROTEASE ACTIVITY IN BIOLOGICAL SYSTEMS - The invention relates generally to compositions and methods for detecting protease activity in a subject or a biological sample using activatable antibodies, and the use of these compositions and methods in a variety of diagnostic indications. | 2021-12-09 |
20210382054 | METHODS FOR SCREENING UBIQUITIN LIGASE AGONISTS - Disclosed herein are methods for identifying a ubiquitin ligase agonist, and the methods include (a) contacting a ubiquitin ligase with a candidate agonist and a neo-substrate; and (b) determining whether the candidate agonist is effective to result in binding the ubiquitin ligase to the neo-substrate, wherein binding of the ubiquitin substrate to the neo-substrate identifies the candidate agonist as a ubiquitin ligase agonist. | 2021-12-09 |
20210382055 | USES OF 4210 DA PEPTIDE AS A MARKER IN DIAGNOSIS OF LIVER CANCER AND CIRRHOSIS - Disclosed herein are uses of 4210 peptide as a marker in the diagnosis of liver cancer and cirrhosis. The 4210 Da peptide is differentially expressed in the serum samples of subjects with different hepatitis B-associated liver diseases, specifically, the expression level is the highest in patients with chronic hepatitis B, sequentially followed by patients with cirrhosis and hepatocellular carcinoma, and healthy controls and those with natural clearance of hepatitis B virus have the lowest expression level of the 4210 Da peptide. The invention provides a novel marker for assisting the diagnosis of a hepatitis B-associated liver disease, which can effectively assist the diagnosis of the hepatocellular carcinoma and the cirrhosis developed from chronic hepatitis B, benefiting the early diagnosis of hepatitis B-associated liver diseases. | 2021-12-09 |
20210382056 | Method for Rapid Accurate Dispensing, Visualization and Analysis of Single Cells - The present disclosure provides methods, device, assemblies, and systems for dispensing and visualizing single cells. For example, provided herein are systems and methods for dispensing a dispense volume into a plurality of wells of a multi-well device, where, on average, a pre-determined number of cells (e.g., 1-20) are present in the dispense volume, and determining, via a cellular label, the number of cells present in each of the plurality of wells. Such dispensing and cell detection may be repeated a number of times with respect to wells identified as having less than the pre-determined number of cells in order increase the number wells in the multi-well device containing the desired number (e.g., a single cell). | 2021-12-09 |
20210382057 | DETECTION OF PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) EXPRESSION ON CIRCULATING TUMOR CELLS (CTC) - The disclosure provides a method for detecting prostate specific membrane antigen (PSMA) on circulating tumor cells (CTCs) obtained from a patient afflicted with prostate cancer comprising (a) performing a direct analysis comprising immunofluorescent staining and morphological characterization of nucleated cells in a blood sample obtained from the patient to detect circulating tumor cells (CTC), and (b) determining the number of CTCs expressing PSMA. The disclosure also provides a provides a method for identifying a patient afflicted with prostate cancer as a candidate for PSMA targeted therapy comprising (a) performing a direct analysis comprising immunofluorescent staining and morphological characterization of nucleated cells in a blood sample obtained from the patient to detect circulating tumor cells (CTC), (b) determining prevalence of a CTC subpopulation expressing PSMA, and (c) comparing the prevalence of the CTC subpopulation expressing PSMA to a reference value, wherein the prevalence of the CTC subpopulation expressing PSMA above the reference value identifies the patient as a candidate for PSMA targeted therapy. The disclosure further provides a provides a method for predicting resistance to androgen receptor (AR) targeted therapy a patient afflicted with prostate cancer comprising (a) performing a direct analysis comprising immunofluorescent staining and morphological characterization of nucleated cells in a blood sample obtained from the patient to detect circulating tumor cells (CTC), (b) determining prevalence of a CTC subpopulation expressing PSMA, and (c) comparing the prevalence of the CTC subpopulation expressing PSMA to a reference value, wherein the prevalence of the CTC subpopulation expressing PSMA above the reference value is indicative of resistance to androgen receptor (AR) targeted therapy. | 2021-12-09 |
20210382058 | PATIENT SELECTION FOR TREATMENT OF MYC POSITIVE CANCERS WITH INDENOISOQUINOLINES - The present disclosure is directed to a method for selecting a patient with cancer for treatment with a compound of formula (I) by determining if the patient's cancer cells are MYC-positive and when the MYC promoter sequence in those cancer cells contains a nucleic acid sequence capable of forming a MYC G-quadruplex (MYC G4) (i.e. are MYC G4-positive) and treating the patient with a compound of formula (I). | 2021-12-09 |
20210382059 | APTAMERS AND USES THEREOF - Methods and compositions are provided for specific aptamers and aptamer pools that bind biomarkers of interest such as microvesicle surface antigens or functional fragments of microvesicle surface antigens. In various embodiments, aptamers of the invention are used in diagnostic, prognostic, or theranostic processes to screen a biological sample for the presence or levels of biomarkers such as microvesicles that are determined to provide a diagnostic, prognostic, or theranostic readout. The diagnosis, prognosis, or theranosis may be related to cancer or other diseases and disorders. The invention also provides methods and composition to facilitate aptamer library screening and aptamer detection methods. | 2021-12-09 |
20210382060 | FLUORESCENT PROBE AND PREPARATION METHOD AND USE THEREOF - Provided are a fluorescent probe, a preparation method therefor and a use thereof. The fluorescent probe sensitively and specifically responds to viscosity, and can be used for the specific fluorescence labeling of proteins as well as in the quantification, detection or kinetic study of proteins and the imaging of cells, tissues and living bodies. | 2021-12-09 |
20210382061 | MULTIPLEXED SINGLE-CELL ANALYSIS USING OPTICALLY-ENCODED RNA CAPTURE PARTICLES - An apparatus for capturing biological material. The apparatus includes: an optically readable capture particle (ORCP) including: one or more optically readable particles (ORPs) each including an optical barcode to identify the ORCP; and a plurality of biological capture sites associated with the one or more ORPs, each of the plurality of biological capture sites including a cellular barcode to identify the ORCP. | 2021-12-09 |
20210382062 | ANALYSIS APPARATUS - An analysis apparatus ( | 2021-12-09 |
20210382063 | GLUCOSE SENSORS AND METHODS OF USE THEREOF - Described herein are glucose sensors. The sensors are composed of host cells incorporating DNA devices specifically designed to produce fluorescence when the cells come into contact with glucose from a patient sample. Once the fluorescence has been quantified, it can be correlated with the amount of glucose present in the sample. Also described herein are extracts from the host cells that can sense and measure glucose levels in a patient. The devices and extracts disclosed herein are inexpensive but sensitive and accurate enough for use in both home and clinical testing situations. The devices and extracts disclosed herein are also useful for diagnosis of diabetes, pre-diabetes, or other diseases associated with elevated glucose levels. | 2021-12-09 |
20210382064 | GENERATION OF HUMAN ALLERGEN- AND HELMINTH-SPECIFIC IGE MONOCLONAL ANTIBODIES FOR DIAGNOSTIC AND THERAPEUTIC USE - The present disclosure is directed to human monoclonal IgE antibodies, and IgG antibodies engineered therefrom. Such engineered antibodies can be used to blunt pathologic IgE responses in subjects, such as in the treatment or prevention of allergies. | 2021-12-09 |