49th week of 2013 patent applcation highlights part 51 |
Patent application number | Title | Published |
20130323673 | DENTAL APPARATUS, MEDICAL APPARATUS AND CALCULATION METHOD - There is provided a dental apparatus including a light source for emitting a light to irradiate at least one of a tooth, a gum, a plaque and a calculus of an oral cavity, a light detector for detecting fluorescence from the oral cavity emitted to the light irradiated from the light source, and a control unit for outputting first data for visualizing a temporal change in a fluorescence intensity based on the fluorescence detected by the light detector. Also, there is provided a calculation method including irradiating an excited light, detecting a fluorescence intensity, and calculating a temporal change in the fluorescence intensity in a depth direction. | 2013-12-05 |
20130323674 | DENTAL APPARATUS, IMAGE ACQUISITION METHOD, AND INFORMATION PROCESSING APPARATUS - A dental apparatus includes a light irradiation unit for emitting a light to irradiate an oral cavity, an image capturing unit for image-capturing the oral cavity light irradiated by the light irradiation unit, and an output unit for outputting data for highlighting and displaying at least one of a plaque site and a calculus site on an image of the oral cavity based on an image captured result by the image capturing unit. | 2013-12-05 |
20130323675 | APPARATUS AND METHOD FOR CONTROLLED FLUID COOLING DURING LASER BASED DENTAL TREATMENTS - A system for dental tissue treatment includes a system for directing a laser beam to an area of dental tissue to be treated, and a fluid-delivery system for directing and controlling a flow of a fluid. The fluid is directed to at least a portion of the area to be treated and the fluid flow is controlled to substantially prevent both a change in laser energy absorption by the dental tissue and attenuation of treatment efficiency due to fluid interference with the laser beam. The fluid present in at least a portion of the area to be treated may prevent or reduce the likelihood of melting of enamel in that area. | 2013-12-05 |
20130323676 | DEVICE FOR CLAMPING CASTS IN DENTAL ARTICULATORS - The invention relates to a device for mounting and temporarily clamping dental casts using multi-functional receiving formwork elements that secure the dental casts, allowing the ratio measurements to be repeated as many times as desired using telescopic cylinders having a memory unit, said cylinders being manual and/or mechanical with screws and/or pneumatic and/or hydraulic and being used to secure, support and universally calibrate the multi-functional receiving formwork element of the dental articulator, thereby allowing the dental record of the casts to be created. | 2013-12-05 |
20130323677 | Individualized endosseous dental implant - The instant invention is an individualized anatomic tooth root implant comprised of zirconia oxide or other biocompatible material, manufactured to very closely approximate an extracted tooth root and the existing extracted tooth root socket morphology. By so doing, invasive drilling and other dental procedures can be avoided. The implant consists of single or multiple root(s), the main implant body, a custom built abutment, and a dental prosthesis (crown), cemented to the abutment once sufficient healing and osseointegration has occurred. The the instant invention will have user defined additions and subtractions with circumferential grooves and ridges cut into the implant body below the coronal lip to insure better fit and retention. | 2013-12-05 |
20130323678 | DENTAL IMPLANT SYSTEM HAVING ENHANCED SOFT-TISSUE GROWTH FEATURES - A dental implant system including an implant and an abutment is disclosed. The implant includes a generally cylindrical body, a central axis, a distal end for anchoring in a patient's bone and a proximal end opposing the distal end. The proximal end includes a roughened lateralized surface that surrounds an abutment-engaging region. The lateralized surface is disposed at a negative slope relative to the central axis. The abutment includes an upper portion for supporting a tooth-like prosthesis and a lower portion for engaging the abutment-engaging region of the dental implant. The diameter of the lower portion of the abutment is smaller than the diameter of the implant at its proximal end. The lower portion includes a first surface with a soft-tissue enhancing material. The first surface and the lateralized surface defining a circumferentially extending recess having a V-shaped cross-section for receiving and attachment to the soft tissue. | 2013-12-05 |
20130323679 | DENTURE STABILIZATION SYSTEM AND METHOD - Provided is a removable denture system including a personalized support beam configured to be fixedly attached to an individual's jaw bone by plurality of dental implants; personalized denture conforming with dental parameters of the individual including bottom surface shaped and sized to constitute a super-structure configured for cooperating with the support beam; and denture locking arrangement for securely locking and unlocking the denture to the support beam, one of the support beam and the super-structure includes one or more positioning grooves extending parallel to a path of insert (POI) of the denture, and the other of super-structure and the support beam, includes one or more corresponding laterally projecting positioning projections, each positioning projection configured to cooperate with a corresponding positioning groove, and configured to provide at least partial snug fit together, the support beam and super-structure are configured to eliminate movement when the super-structure is assembled over the support beam. | 2013-12-05 |
20130323680 | DENTAL RESTORATIVE SYSTEM AND COMPONENTS - Disclosed within is a dental restorative system including a dental abutment having a longitudinal axis, lingual and facial aspects, a base portion for engagement with a dental implant, and a tapered coronal portion. The dental abutment further includes an emergence profile portion between the base portion and the tapered coronal portion. The emergence profile portion includes at least a first concave surface and at least a first convex surface. The dental abutment may further include an interproximally sloping margin shoulder and a reduced terminal portion located at the upper end of the tapered coronal portion. Alternative embodiments of the dental abutment are also disclosed. | 2013-12-05 |
20130323681 | LOCKING TAPER ABUTMENT WITH WEAKENED ZONE - A locking taper abutment with a weakened zone is disclosed, which includes a first portion, a second portion and a third portion. The first portion is used to be disposed inside an opening of a dental implant. The second portion connects to the first portion and has a structurally weakened zone to enable the possible fracture of the locking taper abutment to occur here. The third portion connects to the second portion and is used for joining with a dental prosthesis. After the locking taper abutment is fractured at the structurally weakened zone, the remained second portion protrudes from the opening. Therefore, the remained second portion can be directly taken out by an instrument so as to reduce the difficulty of clinical operation obviously. Furthermore, the opening wall of the dental implant will not be hurt, and the bacterial closure of the dental implant will not be destroyed. | 2013-12-05 |
20130323682 | ARTIFICIAL TEETH - Artificial teeth arranged in plates attachable in an oral cavity as a dental prosthetic appliance, in which arrangement direction indication parts showing a directivity of arrangement in the plates extending in an apical-cervical direction or in a mesiodistal direction are provided at a vestibular side or an oral side. The arrangement direction indication parts extending in the apical-cervical direction are positioned linearly as seen from the vestibular side in an occluded state of mandibular teeth and maxillary teeth. The arrangement direction indication parts extending in the mesiodistal direction are positioned linearly as seen from the vestibular side in the state in which the teeth are arranged in the plates. The artificial teeth are arranged at an appropriate position according to an oral environment of each patient, without requiring advanced skill and experience. | 2013-12-05 |
20130323683 | PHOTOTHERAPY DEVICES AND METHODS - The present disclosure relates to a phototherapy device that can deliver light to tissues to activate photoactive agents that have been applied to the tissues or that are included within a fiber optic tip member of the device which may be coupled to a light source using a sleeve. The present disclosure also relates to methods of phototherapy using the phototherapy device such as anti-bactericidal treatment, anti-fungal treatment, anti-parasitic treatment, anti-viral treatment. | 2013-12-05 |
20130323684 | APPARATUS AND METHOD FOR CONTROLLED FLUID COOLING DURING LASER BASED DENTAL TREATMENTS - A system for dental tissue treatment includes a system for directing a laser beam to an area of dental tissue to be treated, and a fluid-delivery system for directing and controlling a flow of a fluid. The fluid is directed to at least a portion of the area to be treated and the fluid flow is controlled to substantially prevent both a change in laser energy absorption by the dental tissue and attenuation of treatment efficiency due to fluid interference with the laser beam. The fluid present in at least a portion of the area to be treated may prevent or reduce the likelihood of melting of enamel in that area. | 2013-12-05 |
20130323685 | DENTAL RESTORATIVE COMPOSITE WITH LUMINESCENT CRYSTALS - A dental restorative composite and a method of curing the composite are disclosed in which the composite includes a polymerizable organic resin, a radiation activated initiator having an activation wavelength, an inert filler; and luminescent crystals, wherein the luminescent crystals emit radiation at a predetermined wavelength matching the initiator activation wavelength when the luminescent crystals are irradiated with radiation having a wavelength longer than the activation wavelength, the luminescent crystals being up-converting particles that result in those particles emitting radiation at a wavelength that initiates curing. | 2013-12-05 |
20130323686 | EMBEDDED SIMULATOR METHOD AND RELATED SYSTEM - A system and method is disclosed for correlation of received objects offering a valid presentation to an operator. The method correlates actual objects and simulated objects to offer a valuable training presentation environment to an operator. The method may receive a plurality of data streams including sensed data, simulated sensed data, and truth data to correlate among the plurality of data to determine if the data corresponds to a common object. Each of these data streams may be received from an off-board source via datalink or generated by an onboard simulation data source. The system correlates data received from an onboard source with data received from an off-board source to present the best available training scenario to the operator. | 2013-12-05 |
20130323687 | TRAINING DATA MANAGEMENT METHOD AND RELATED SYSTEM - A training data management method and related system is disclosed comprising three integrated elements. A training data network may provide a network linking a remote instructor operating an off-board data network with a student operating an onboard data network. The remote instructor may, via the datalink connection, maintain a level of control of the data set available to the student. A method for providing training data may include an onboard and off-board safety monitor configured for perceiving a safety event and sending a notification thereof to an involved participant. A system for providing training data may include a data guard configured to monitor all communications between two networks and block sensitive information, training data, and classified communications between the networks. | 2013-12-05 |
20130323688 | ALERT GENERATION AND RELATED AIRCRAFT OPERATING METHODS - A method of operating an aircraft during a flight is provided. An onboard monitoring subsystem of the aircraft detects that a flight crew member is fatigued, and an automated flight crew training exercise is activated in response to detecting that the flight crew member is fatigued. The flight crew member is then engaged with the automated flight crew training exercise, including instructions intended to alleviate flight crew fatigue. | 2013-12-05 |
20130323689 | FILL-IN-THE-BLANK AUDIO-STORY ENGINE - Embodiments of the present invention are generally directed to an Audio-Story Engine that includes a repository of prerecorded audio files that, when played in a certain sequence, with user provided recordings placed throughout, tell a story. To obtain the user provided recordings, the Audio-Story Engine asks the user to make audio recordings of various words or phrases. For example, the Audio-Story Engine may ask the user a series of questions in order to record and store the user's audible responses. Upon completion, the Audio-Story Engine plays back a completed story that incorporates the user's audio recordings by playing an appropriate user recording after playing a prerecorded audio file. This is repeated several times in sequence to form a seamless, customized, audio story. In addition, the Audio-Story Engine may alter the pitch or sound of the user's recorded words to match the pitch of the prerecorded story. | 2013-12-05 |
20130323690 | PROVIDING AN UNINTERRUPTED READING EXPERIENCE - An uninterrupted reading experience can be provided by calculating a vocabulary level for a user in a first language and comparing difficulty levels of words within a document in the first language to the vocabulary level of the user in the first language. Each word of the document having a difficulty level that exceeds the vocabulary level of the user in the first language can be selected. | 2013-12-05 |
20130323691 | DEVICE AND METHOD FOR COMPUTER-ASSISTED LEARNING - A method for the computer-assisted learning of orthography, the method includes executing the following steps by a data processing system:
| 2013-12-05 |
20130323692 | Education Game Systems and Methods - The present disclosure provides education game systems and methods that display key words and distractor words simultaneously across a user interface such that a student can practice identifying and applying key words to improve their overall score on standardized exams. | 2013-12-05 |
20130323693 | PROVIDING AN UNINTERRUPTED READING EXPERIENCE - An uninterrupted reading experience can be provided by calculating a vocabulary level for a user in a first language and comparing difficulty levels of words within a document in the first language to the vocabulary level of the user in the first language. Each word of the document having a difficulty level that exceeds the vocabulary level of the user in the first language can be selected. | 2013-12-05 |
20130323694 | SYSTEM AND METHOD FOR IMPROVED HUMAN LEARNING THROUGH MULTI-SENSORY STIMULUS - Disclosed herein are systems, methods, and computer-readable storage media for improving human learning by providing multi-sensory stimulus. A system narrates a text to a user at a narration pace, while determining a focal point of the user's gaze using both a camera and eye tracking analysis. The system determines a user pace based on a shift in the gaze focal point during narration of the text, then adjusts the narration pace based on the user pace. The adjustment is performed based on a selection of a retention mode and a development mode. The retention mode maintains the narration pace with the user pace for maximal user retention of the text. The development mode increases the narration pace with respect to the user pace for user reading rate acceleration. | 2013-12-05 |
20130323695 | SIMULATOR FOR SKILL-ORIENTED TRAINING - A simulator for skill-oriented training is presented. The simulator includes a platform having a platform sensor and provides a training environment depicting a work piece rendered on the platform. The simulator includes a display unit worn by a person operating the simulator. The unit includes a camera, a speaker and a unit sensor. The camera and the speaker provide visual and audio output to the person depicting the training environment. The simulator includes a controller and a data processing system. The controller is operated by the person and includes a controller sensor. The sensors cooperate to provide to the processing system signals representing spatial positioning, angular orientation and movement data of the controller relative to the platform. In response, the processing system renders the work piece, a virtual coating spray pattern, a virtual coating as applied to the work piece and performance guidance in the training environment. | 2013-12-05 |
20130323696 | System and Method for Task-Based Training Assignment for Training on Clinical Trials - The invention provides a method and system for efficiently apportioning, delivering and monitoring training to clinical trial participants. The invention ensures that each person participating in a given clinical trial receives only the training that they actually need in order to perform their assigned tasks on the trial. The invention reduces the amount of unnecessary training typically taken by staff working on a clinical trial, accelerates the startup of the trial and ensures that staff receives the necessary training for the specific tasks they are performing on the trial. | 2013-12-05 |
20130323697 | CRYPTOGRAPHIC EDUCATIONAL PUZZLE - Educational puzzle and game comprising a cryptographic object that carries an invisible ciphertext that can transformed to a visible state from its invisible state only in response one or more operations or manipulations. The puzzle-solver or game player can strategize on how to perform operations on the cryptographic object, which in can comprises trial and error methods based on his or her educational or scientific background. | 2013-12-05 |
20130323698 | METHODS AND APPARATUS FOR INTERPERSONAL COORDINATION ANALYSIS AND TRAINING - Methods and systems for interpersonal coordination analysis and training are provided. In an example embodiment of a method for interpersonal coordination analysis and training, at least one physical action is selected to be performed. A leader subject is instructed to perform the at least one physical action in the presence of at least one follower subject. The at least one physical action of the leader subject is tracked. The at least one follower subject is instructed to mimic the at least one physical action of the leader subject. The at least one physical action of the at least one follower subject is tracked. Tracking data obtained from the tracking of the leader subject and the at least one follower subject is analyzed. From the analyzing of the tracking data, a responsiveness of the at least one follower subject to mimic the leader subject can be determined. | 2013-12-05 |
20130323699 | SIMULATED MEDICAMENT DELIVERY DEVICE HAVING AN ELECTRONIC CIRCUIT SYSTEM - Medicament delivery devices and simulated medicament delivery devices are described herein. An apparatus includes a simulated medicament injector. The simulated medicament injector includes a battery isolation member and an electronic circuit system having a processor. The battery isolation member is configured to selectively decouple a battery from the processor. | 2013-12-05 |
20130323700 | HYBRID PHYSICAL-VIRTUAL REALITY SIMULATION FOR CLINICAL TRAINING CAPABLE OF PROVIDING FEEDBACK TO A PHYSICAL ANATOMIC MODEL - Systems and methods facilitating training in clinical procedures via mixed reality simulations are disclosed. Such a system can comprise a physical model and a virtual model of an anatomic region associated with the procedure, wherein the virtual model associates tissue types with locations in the physical model. The system can include a tracking component that tracks locations of at least one clinical instrument relative to the models, and an anatomic feedback component that can produce perceptible changes in the physical model based on the interaction between the instrument and virtual model. A clinical device interface can detect outputs of clinical devices like electrical signals, pressure or flow, wherein feedback to the physical model depends on the tracked position of a clinical device and output from the same or different clinical device. Another component can generate feedback effects to the clinical device. Aspects can simulate anesthesiology procedures like local nerve blockade. | 2013-12-05 |
20130323701 | DEMONSTRATOR OF MULTIPLE STRESSES - An article is described that can be used as a demonstrator of multiple stresses making it possible notably to compare the results of simulation tests for various types of mechanical stresses. The demonstrator can be an article made in a single piece out of plastic material having a ribbed central beam and two lateral plates. Bending, tensile, compression and torsion tests can notably be carried out on such a demonstrator. | 2013-12-05 |
20130323702 | METHODS AND APPARATUS FOR DISTRIBUTING AND CONTROLLING THE DISTRIBUTION OF KARAOKE SHOW SONGS - A system, method and software allows a karaoke host's music collection to reside in one physical location (such as a CD server) or as a digital copy (on a central server) and all the music can be accessed via client karaoke hosting software. When a client karaoke show hosting application is playing a song from the central client/server, the software marks that song as being “checked out” while it is being played/in use. This keeps that song from being able to be played by multiple hosts at the same time. Discs or digital files are able to be stored centrally, preventing loss or damage, and multiple clients can use the same karaoke collection without violating licensing laws. The software allows the discs to be stored centrally, avoiding the need to carry them to shows and manually handle them, thereby minimizing the risk of lost, damaged, or stolen discs. | 2013-12-05 |
20130323703 | Study Aid for Academic Competition - Disclosed is a study aid with multiple modes that allows users (especially students who participate in academic competitions) to develop expertise within a given subject by playing a game where detailed clues to entries related to the subject are provided in a random order from hardest to easiest. The clues and the ancillary information provided with the clues may also be studied without playing the game. The study aid uses a data interface device such as a computer, smartphone or tablet, including the Apple Computer, Inc. iPhone and iPad. | 2013-12-05 |
20130323704 | SYSTEMS AND METHODS FOR ASSESSMENT OF FLUID INTELLIGENCE - A computing device determines a matrix reasoning assessment (MRA) to assess fluid intelligence of a user operating a client computer/device. The MRA includes a matrix having designs in design spaces, where the designs form one or more patterns. The matrix has one or more design spaces in the matrix that are missing a design. Examples of a design include, without limitation, a number, a letter, a symbol. a shape, a picture, an image, a photograph, an icon, an animation, a video, audio, or any other symbol, character, or representation that can be used in a pattern. In one embodiment, the computing device transmits the matrix to the client device. The user responds with a design for the “empty” design space (i.e., the design space previously missing a design) and the computing device receives this design selection. | 2013-12-05 |
20130323705 | CONTENT PROVIDING SYSTEM AND CLIENT TERMINAL - An exemplary content providing system includes a server in which a learning management system is established using teaching material data and a client terminal which downloads the teaching material data from the server and presents the data. The teaching material data includes teaching material management data and content data, which are associated with each other. The client terminal includes a processor which downloads the content data from the server at a predetermined time, and a storage device which stores the content data that has been downloaded. The processor downloads management data, which is associated with the content data downloaded, at or after the predetermined time, and combines the management data and the content data together according to the association between the management data and the content data, thereby generating teaching material data to present. | 2013-12-05 |
20130323706 | Electronic performance management system for educational quality enhancement using time interactive presentation slides - This patent refers to a method of achieving greater quality assurance of teaching in classroom settings by the use of an electronic performance management system; the basis being modifying the use and nature of presentation slides. Essentially, this patent deals with timed presentation slides and interactive elements within these slides. Each slide is assigned an estimated duration and then compared with actual recorded duration; furthermore, certain words within the slide are made interactive. Based on this comparison and whether the interactive words are stimulated, the proposed software allows real-time monitoring of teaching variables such as coverage, depth, contact hours, etc. | 2013-12-05 |
20130323707 | INFORMATION BOARD WITH INTERCHANGEABLE GRAPHIC LAYER - Information boards include a graphic layer and a transparent or translucent dry erase writing surface. The information boards include one or more non-permanent attachment mechanisms that allow for selective removal and replacement of the graphic layer. Additionally, the information boards can optionally include a magnetically attractable layer positioned behind the graphic layer. The magnetically attractable layer can allow for the attachment of notes or other objects to the dry erase writing surface via a magnet. One will appreciate that implementations of the present invention are particularly suited for use in homes, schools, hospitals, businesses, and other locations where removing and replacing a graphic layer in a dry erase board may be desired. | 2013-12-05 |
20130323708 | ISOLATED ADULT CELLS, ARTIFICIAL ORGANS, REHABILITATED ORGANS, RESEARCH TOOLS, ORGAN ENCASEMENTS, ORGAN PERFUSION SYSTEMS, AND METHODS FOR PREPARING AND UTILIZING THE SAME - One aspect of the invention provides a method for harvesting adult cells from an organ. The method includes perfusing the organ with a perfusate and isolating adult cells from the organ, thereby harvesting the adult cells from the organ. Another aspect of the invention provides a method for rehabilitating an organ. The method includes: dividing the organ into a first portion and a second portion, perfusing the first portion with a decellularization medium, isolating adult cells from the second portion, and recellularizing the first portion with a suspension of the adult cells, thereby rehabilitating the organ. | 2013-12-05 |
20130323709 | Treating Heart Tissue - Some embodiments of a system or method for treating heart tissue can include a catheter device that provides a user with the ability to perform a number of heart treatment tasks (before, during, and after a cardiac surgery or a percutaneous coronary intervention). In particular embodiments, the catheter device can be used to (i) precondition heart muscle tissue before the heart is isolated from the circulatory system, (ii) deliver cardioplegia into the coronary sinus during the cardiac surgery when the heart is isolated from the circulatory system, and (iii) control the blood flow through the heart after the heart is reconnected with the circulatory system. In some embodiments, the catheter device can perform some or all of: (i) intermittently occluding the coronary sinus, (ii) delivering a treatment fluid into the coronary sinus, and (iii) monitoring a flow rate of blood passing from the coronary sinus to the right atrium. | 2013-12-05 |
20130323710 | Methods for Inducing the Differentiation of Blood Monocytes into Functional Dendritic Cells - Methods are provided for treating blood monocytes to produce functional antigen presenting dendritic cells. An extracorporeal quantity of a subject's blood is treated to separate the blood into a plasma component containing proteins, a platelet component and a buffy coat component. A plastic treatment device is provided having plastic channels that allow transmittance of light to the interior of the plastic device and a light source that produces light of a wave length selected to activate the photoactivatable agent. The plasma component containing proteins is first pumped through the plastic treatment device, followed by the platelet component and finally the buffy coat component. The resulting treated cells may be incubated or reinfused directly to the subject. | 2013-12-05 |
20130323711 | APPARATUS AND METHOD FOR ISOLATING LEUKOCYTES AND TUMOR CELLS BY FILTRATION - The present invention provides novel apparatuses and methods for isolating or recovering a subset of blood cells such as leukocytes and/or circulating tumor cells from blood samples by filtration without changing the intracellular concentration of a therapeutic agent such as an anticancer drug. Contrary to the art, the apparatuses and methods of the present invention advantageously provide cell lysates from recovered cells such as leukocytes and/or circulating tumor cells without substantial dilution of a therapeutic agent such as an anticancer drug. | 2013-12-05 |
20130323712 | METHOD AND MATERIAL FOR SEPARATING LEUKOCYTES OR MONONUCLEAR CELLS - An object of the present invention is to provide a separation system and a separation material for efficiently separating white blood cells or mononuclear cells from a biological fluid containing blood cell components. White blood cells or mononuclear cells can be efficiently separated by contacting a biological fluid containing blood cell components with a separation material having an average fiber diameter of at least 2.0 μm but not more than 6.0 μm and an air permeability coefficient M of at least 6.2 but not more than 35 to capture white blood cells on the separation material, and recovering the captured white blood cells or mononuclear cells using a detachment solution. | 2013-12-05 |
20130323713 | SUN TRACKING LIGHT DISTRIBUTOR SYSTEM HAVING A V-SHAPED LIGHT DISTRIBUTION CHANNEL - A sun-tracking light distributor system for use in one of an open-ended system and a closed photo-bioreactor for a photosynthetic culture having an aqueous liquid. The sun-tracking light distributor system comprises two light distribution walls, provided at an angle and oriented to converge at a bottom end, the light distribution walls being made of a transparent material allowing sunlight to pass therethrough, the two converging light distribution walls creating an elongated V-shaped channel with an interior space adapted to receive the sunlight and an exterior surface adapted to be partly immersed in the aqueous liquid in use; and a displacement system operatively connected to at least one of the two light distribution walls, the displacement system being adapted to change an orientation of at least one of the two light distribution walls to track a solar position with respect to at least one axis. | 2013-12-05 |
20130323714 | SYSTEM AND METHOD FOR MICRO-AERATION BASED FERMENTATION - A method and apparatus for micro-aeration of large scale fermentation systems is provided. The micro-aeration system includes a fermentation reactor, a sparging apparatus, and a micro-aeration gas mixture delivered to the fermentation reactor via the sparging apparatus. The micro-aeration gas mixture is a very low oxygen concentration mixture comprising an oxygen containing gas and an inert carrier gas that is preferably recycled through the fermentation reactor. The inert carrier gas is preferably nitrogen whereas the oxygen containing gas is oxygen or and is introduced to the fermentation reactor at a minimum superficial velocity of about 0.02 m/sec to produce a uniform dispersion of the oxygen/air throughout the fermentation broth while concurrently mixing the entire fermentation broth. The micro-aeration method and apparatus further comprises a controller operatively coupled to one or more control valves for regulating the micro-aeration conditions in the fermentation reactor. | 2013-12-05 |
20130323715 | CONTAINER STORING FREEZE-DRIED BIOLOGICAL SAMPLE - Embodiments of the invention relate to a container holding, and a method of storing, freeze-dried biological samples. In particular, there is provided a container holding a freeze-dried material comprising a biological sample, the container comprising a chamber having an upper portion and a lower portion, the chamber comprising a wall and the lower portion being fluidly connected to the upper portion such that, when liquid is received at the upper portion, the received liquid can pass to and accumulate in the lower portion. Further, the freeze-dried material is located in the lower portion, and the container comprises a physical structure in the form of a stop protruding inwards from the wall, the physical structure being for inhibiting the freeze-dried material from moving from the lower portion of the chamber to the upper portion of the chamber. This ensures that the biological sample can be kept in a lower portion of the tube, ensuring that, when the biological sample is subsequently reconstituted by inserting water, substantially all of the biological sample is dissolved. | 2013-12-05 |
20130323716 | SIGNAL ENCODING AND DECODING IN MULTIPLEXED BIOCHEMICAL ASSAYS - This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte. | 2013-12-05 |
20130323717 | REPEAT-CHAIN FOR THE PRODUCTION OF DIMER, MULTIMER, MULTIMER COMPLEX AND SUPER-COMPLEX - The present invention relates to a method for manufacturing multimers by making repeat-chains comprising repeatedly linked affinity domains binding specifically to monomers, and by using the same to create a repeat-chain/multiple-monomer complex created from the repeat-chains and a multiple number of monomers, thereby facilitating the formation of bond bridges between the monomers in the complex to produce inter-monomeric bond bridged multimer. | 2013-12-05 |
20130323718 | Methods for the Characterization of Microorganisms on Solid or Semi-Solid Media - The present invention relates to methods and systems for scanning, detecting, and monitoring microorganisms on solid or semi-solid media using intrinsic fluorescence (IF) measurements. The methods are further directed to detection, characterization and/or identification of microorganisms on a solid or semi-solid media using intrinsic fluorescence (IF) measurements that are characteristic of said microorganisms. | 2013-12-05 |
20130323719 | NEW IRIDIUM-BASED COMPLEXES FOR ECL - Novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, for example in the electrochemiluminescence based detection of an analyte. | 2013-12-05 |
20130323720 | COMBINATION OF BIOMARKERS FOR THE DETECTION AND EVALUATION OF HEPATITIS FIBROSIS - The application concerns means for determining the stage of hepatic tissue damage, in particular the hepatic fibrosis score of subjects infected with one or more hepatitis viruses. In particular, the means of the invention involve measuring the levels of expression of selected genes, said selected genes being:
| 2013-12-05 |
20130323721 | HEPATOCYTES FOR IN VITRO GENOTOXICITY TESTS - The invention relates to a method for carrying out genotoxicity tests of chemical, biological and physical active substances or agents with the aid of cell culture systems of proliferating physiologically active liver cells. | 2013-12-05 |
20130323722 | Methods for High Fidelity Production of Long Nucleic Acid Molecules - In a method for generating a long nucleic acid molecule, nucleic acids immobilized on a surface and having overlapping complementary sequences is released into solution. The overlapping complementary sequences are hybridized to form hybridized nucleic acids, followed by extension or ligation of the hybridized nucleic acids to synthesize the long nucleic acid molecule. The nucleic acids may comprise first and second series of nucleic acids having redundant overlapping sequences, wherein nucleic acids from the first and second series are complementary to each other. The complementary nucleic acids are hybridized to form the hybridized nucleic acids. The generated long nucleic acid molecule may have a predetermined sequence element, and it may be introduced into a system wherein the predetermined sequence element is required for replication, such that replication of the synthesized long nucleic acid molecule is indicative of the presence of the predetermined sequence element in the long nucleic acid molecule. | 2013-12-05 |
20130323723 | SOLID SUPPORT AND METHOD OF RECOVERING BIOLOGICAL MATERIAL THEREFROM - The present invention relates to solid supports that are used for the storage and further processing of biological materials. The invention is particularly concerned with solid supports which have at least one surface coated with a chemical mixture that enhances the recovery of the biological material from the support. Methods of preparing and using the solid supports are also described. | 2013-12-05 |
20130323724 | Chemiluminescence Proximity Nucleic Acid Assay - This invention relates to the detection and quantitation of target nucleic acids in a heterogeneous mixture in a Sample and the methods of use thereof. The detection system includes a chemiluminescent molecule, a chemiluminescent substrate, a dye that is light responsive when intercalated into nucleic acids and nucleic acids. This invention is useful in any application where detection of a specific nucleic acid sequence is desirable, or where the detection of enzymes that modify nucleic acids is desirable such as diagnostics, research uses and industrial applications. | 2013-12-05 |
20130323725 | TARGET ENRICHMENT AND LABELING FOR MULTI-KILOBASE DNA - This disclosure provides a method comprising: a) clamping the top and bottom strands of a double stranded DNA molecule to produce a duplex in which the top and bottom strands are linked; b) denaturing the duplex to produce a denatured product; and c) renaturing the denatured product in the presence of a labeled oligonucleotide that is complementary to a sequence of nucleotides in the double stranded DNA molecule, thereby producing a D-loop-containing product. Kits for performing the method and products made by the method are also provided. | 2013-12-05 |
20130323726 | METHODS AND MATERIALS USING SIGNALING PROBES - The present invention relates to methods of isolating cells, generating cell lines, and detecting RNAs in cells using signaling probes that produce a signal upon hybridization to a target sequence. Other methods that utilize the signaling probe include methods of detecting or quantifying the effect of an agent on RNAs in a cell, methods of quantifying the level of RNA expression, methods for identifying genetic recombinational events in living cells and methods of generating a transgenic animal using the isolated cells. The invention also provides protease probes. Signaling probes and protease probes that form stem-loop structures, three-arm junction structures, and dumbbell structures are provided. | 2013-12-05 |
20130323727 | METHOD OF DESIGNING PRIMERS, METHOD OF DETECTING SINGLE NUCLEOTIDE POLYMORPHISMS (SNPs), METHOD OF DISTINGUISHING SNPs, AND RELATED PRIMERS, DETECTABLE OLIGONUCLEOTIDES, AND KITS - A method of designing a primer for detecting a single nucleotide polymorphism (SNP), a method of detecting an SNP, a method of distinguishing SNPs, primers, detectable oligonucleotides, and kits. | 2013-12-05 |
20130323728 | METHODS AND KITS FOR DETECTION OF 5-HYDROXYMETHYLCYTOSINE - The present invention relates to methods and kits for the detection of 5-hydroxymethylcytosme (5hmC). In some embodiments, the present invention relates to methods and kits for detection of 5hmC in nucleic acid (e.g., DNA, RNA). In some embodiments, the present invention relates to detection of 5hmC in genomic DNA, e.g., mammalian genomic DNA. | 2013-12-05 |
20130323729 | Proximity Ligation Technology for Western Blot Applications - The invention provides a method for detecting a biomolecular feature (a protein, protein complex, or modified protein such as a phosphorylated protein) by a modified Western blot type of assay, which method either electrophoretic gel separation followed by transfer, or direct spotting of a sample containing the biomolecular feature onto a membrane; providing a proximity probe pair, each probe comprising a binding moiety with affinity for a different binding site on the bio molecular feature and a reactive oligonucleotide, coupled thereto; binding the proximity probes to their respective binding sites on the biomolecular feature through the binding moiety, adding a splint oligonucleotide and a backbone oligonucleotide which are complementary to the reactive oligonucleotide pair, and allowing hybridization among them; ligating the hybridized DNA oligonucleotides to create a circularized DNA molecule when both probes bind sufficiently close to each other on the bio molecular feature, amplifying the circularized DNA by isothermal amplification; and detecting the presence and quantity of the bio molecular feature using a detection oligonucleotide complementary to the amplification product. Also provided are methods for multiplexed detection of more than one bio molecular feature, as well as kits for performing the assays. | 2013-12-05 |
20130323730 | METHOD FOR DETERMINING PLOIDY OF A CELL - A method for determining the ploidy of a test genome is provided. In some embodiments, the method may comprises: a) obtaining a plurality of ratios for polymorphisms that are distributed throughout a test genome, wherein each of the ratios is a ratio of the measured copy number of uncut allele in a polymorphic site relative to the measured copy number of the uncut allele in the reference sample; b) taking the log of the ratios and plotting a distribution of the reference corrected log ratios of the SNP probes; and c) determining the ploidy of said the genome based on the number of peaks in that distribution. | 2013-12-05 |
20130323731 | DETERMINATION OF THE DEPTH COVERAGE OF THE FETAL GENOME - Systems, methods, and apparatus for determining at least a portion of fetal genome are provided. DNA fragments from a maternal sample (maternal and fetal DNA) can be analyzed to identify alleles at certain loci. The amounts of DNA fragments of the respective alleles at these loci can be analyzed together to determine relative amounts of the haplotypes for these loci and determine which haplotypes have been inherited from the parental genomes. Loci where the parents are a specific combination of homozygous and heterozygous can be analyzed to determine regions of the fetal genome. Reference haplotypes common in the population can be used along with the analysis of the DNA fragments of the maternal sample to determine the maternal and paternal genomes. Determination of mutations, a fractional fetal DNA concentration in a maternal sample, and a proportion of coverage of a sequencing of the maternal sample can also be provided. | 2013-12-05 |
20130323732 | SINGLE-PARTICLE ANALYSIS OF PARTICLE POPULATIONS - In certain embodiments, the invention provides methods and devices for assaying single particles in a population of particles, wherein at least two parameters are measured for each particle. One or more parameters can be measured while the particles are in the separate reaction volumes. Alternatively or in addition, one or more parameters can be measured in a later analytic step, e.g., where reactions are carried out in the separate reaction volumes and the reaction products are recovered and analyzed. In particular embodiments, one or more parameter measurements are carried out “in parallel,” i.e., essentially simultaneously in the separate reaction volumes. | 2013-12-05 |
20130323733 | METHODS OF ASSESSING A RISK OF DEVELOPING NECROTIZING MENINGOENCEPHALITIS - Methods of using single nucleotide polymorphisms (SNPs), SNP haplotype block, and haplotype to predict whether or not a subject will develop necrotizing meningoencephalitis (NME) and probe sets that facilitate those methods are disclosed. In preferred forms, the subject is a canine species. | 2013-12-05 |
20130323734 | Genetic Determinants of Prostate Cancer Risk - Described are methods of determining if a subject has a genetic predisposition to developing prostate cancer (PCa), e.g., an American or Caribbean subject of African descent and of reducing their risk. | 2013-12-05 |
20130323735 | MEANS AND METHODS FOR INVESTIGATING NUCLEIC ACID SEQUENCES - The invention provides improved methods for investigating nucleic acid sequences, wherein at least one additional probe is used which is specific for a (pseudo)gene variant of a target nucleic acid. | 2013-12-05 |
20130323736 | POLYNUCLEOTIDE PRIMERS - A polynucleotide primer comprising at least the final six nucleotides of one of the following primer sequences, or a sequence complementary thereto: SEQ. ID NOS. 1 to 18, 21 to 45 or 74 to 77. | 2013-12-05 |
20130323737 | METHOD AND SYSTEM FOR ANALYZING A SAMPLE - A method and system for analysing a sample are provided, wherein one or more process steps and/or sample processors are provided separately from the instrument, for instance a sample receiving step and sample preparation step and sample extraction step and sample retention step and/or purification step and washing step and elution step, and one or more process steps and/or sample processors provided by the instrument as an integrated set, the one or more process steps and/or sample processors provided by the instrument including a sample receiving step and amplification step and denaturing step and investigation step and detection step and results analysis step and results output step. Other combinations of the split in location of the steps are possible. The optimisation of the split allows the accurate processing by a cartridge based instrument of the sample, whilst fully interfacing with a variety of sample collection and/or preparation approaches. | 2013-12-05 |
20130323738 | Detection of Amplification Products - Compositions and methods are provided for quantitative detection of amplification products, the methods being suitable for multiplexing. A first oligonucleotide that includes a primer sequence for priming an amplification reaction and also is labeled with a fluorescent label or quencher is mixed with a second oligonucleotide which has a sequence suitable for hybridizing to a portion of the first oligonucleotide and has a fluorescent label if the first oligonucleotide has a quencher or a quencher if the first oligonucleotide has a fluorescent label; and a third nucleotide which includes some or all the primer sequence contained in the first oligonucleotide but is not labeled, the first and third oligonucleotide being combined in a molar ratio of 2.8 to 8.2. | 2013-12-05 |
20130323739 | METHOD FOR DETERMINING RECURRENCE OR STABLE DISEASE AFTER TREATMENT FOR PROSTATE CANCER - This invention describes compositions and methods for use in PSA assays having low functional sensitivity which are useful, for example, in the detection of early stage recurrence of prostate disease following treatment and in the determination of whether patients have prostate cancer recurrence or stable disease. | 2013-12-05 |
20130323740 | DIRECT BLOOD ASSAY FOR DETECTION OF CIRCULATING MICRORNA IN CANCER PATIENTS - Methods of diagnosing, determining the progression, or determining a prognosis of a cancer in a subject are provided. Such methods may include steps of measuring a test level of one or more miR molecules in a biological sample from the subject; comparing the test level to a control level of the one or more miR molecules; and diagnosing a subject as having a cancer, differentiating between a locoregional cancer and a cancer that has progressed to a cancer with visceral or distant metastasis, or determining a prognosis for the subject having a cancer when the test level is significantly different than the control level. | 2013-12-05 |
20130323741 | AMPLIFICATION SYSTEM WITH SPATIAL SEPARATION - An automated nucleic acid analysis method and analytical system are described comprising separate modules, wherein the air flow of any one of said modules is controlled and wherein at least the air flow between the module for isolation and purification of the analyte and the module for analysis of the analyte are separated. | 2013-12-05 |
20130323742 | Systems and Methods for Enhanced Nucleic acid Seperation - Methods and apparatus for separating, concentrating and/or detecting molecules based on differences in binding affinity to a probe are provided. The molecules may be differentially modified. The molecules may be differentially methylated nucleic acids. The methods can be used in fields such as epigenetics or oncology to selectively concentrate or detect the presence of specific biomolecules or differentially modified biomolecules, to provide diagnostics for disorders such as fetal genetic disorders, to detect biomarkers in cancer, organ failure, disease states, infection or the like. | 2013-12-05 |
20130323743 | RATE BASED IDENTIFICATION OF REACTION POINTS - An apparatus for identifying transition points in a chemical reaction, the apparatus comprising: a property value receiver, configured to receive a plurality of values of a physical property of the chemical reaction, a function calculator, associated with the property value receiver, configured to calculate a function and verify that the function has a line of best fit with a same slope as a linear function connecting two of the received values, the two values pertaining to a start and end of a time period, a difference calculator, associated with the function calculator, configured to calculate a difference between the calculated function and a plurality of the received values pertaining to the time period having the start and end, and a transition point identifier, associated with the difference calculator, configured to identify at least one transition point of the chemical reaction, using the calculated difference. | 2013-12-05 |
20130323744 | Signatures and Determinants Associated with Cancer and Methods of Use Thereof - The present invention provides methods of detecting cancer using biomarkers. | 2013-12-05 |
20130323745 | METHOD OF DETECTING VIABLE CELLS IN A CELL SAMPLE - The invention relates to a method for determining the presence and/or amount of viable cells in a liquid sample. | 2013-12-05 |
20130323746 | GENOTOXICITY AS A BIOMARKER FOR INFLAMMATION - The invention provides a method for detection of inflammatory disease in a subject that comprises assaying a test sample of peripheral blood from the subject for a marker of DNA damage. An elevated amount of marker present in the test sample compared to control sample is indicative of inflammatory disease activity, including sub-clinical inflammation. The method can be adapted for quantitatively monitoring the efficacy of treatment of inflammatory disease in a subject. Markers of DNA damage include single- and/or double-stranded breaks in leukocytes, oxidative DNA damage in leukocytes, or a marker of nitric oxide oxidative activity (protein nitrosylation in leukocytes). The inflammatory disease can be inflammatory bowel disease (ulcerative colitis or Crohn's disease). The invention may also be used for detection of other types of inflammatory disease, such as non-immune intestinal inflammatory disease (diverticulitis, pseudomembranous colitis), autoimmune diseases (rheumatoid arthritis, lupus, multiple sclerosis, psoriasis, uveitis, vasculitis), or non-immune lung diseases (asthma, chronic obstructive lung disease, and interstitial pneumonitis). This unexpected discovery of markers of genotoxicity present in circulating leukocytes enables detection of inflammation occurring at a localized site with a relatively simple and minimally invasive assay using peripheral blood. | 2013-12-05 |
20130323747 | TARGETING AND TRACING OF ANTIGENS IN LIVING CELLS - The present invention relates to a method of detecting the presence, amount or subcellular location of an antigenic structure of interest in a cell. | 2013-12-05 |
20130323748 | METHOD OF JUDGING RISK OF CANCER RECURRENCE AND COMPUTER PROGRAM - There is provided a method of judging a risk of cancer recurrence based on the activity value and expression level of the first CDK, the activity value and expression level of the second CDK, and the expression levels of uPA and PAI-1 and a computer program. | 2013-12-05 |
20130323749 | GRANZYME A AND GRANZYME B DIAGNOSTICS - A method for identifying a subject being at risk for or having a chronic Inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease is provided. The method may include determining the concentration of GrA and/or GrB in a blood or serum sample from said subject; and comparing the concentrations to the corresponding concentration in a control sample, wherein an elevated concentration of GrA and/or GrB may be indicative of a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease. The method may further include identifying concentrations of fibrinogen, elastin and/or fibrillin. | 2013-12-05 |
20130323750 | Method for Analyzing Apoptosis Inducing Factor-2 - A method for analyzing apoptosis inducing factor-2 (AIF-2) is disclosed, which has not been found in urine samples of human patients with chronic kidney disease, to establish AIF-2 as a non-invasive biomarker for chronic kidney disease. The method includes: collecting a plurality of urine samples; conducting western blot for each urine sample for detecting the AIF-2 protein content in each urine sample; and conducting statistical analysis of the AIF-2 protein content in each urine sample to establish AIF-2 as a biological marker for chronic kidney disease. | 2013-12-05 |
20130323751 | Urine Biomarkers For Prediction Of Recovery After Acute Kidney Injury: Proteomics - This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, renal recovery. For example, renal recovery can be determined by monitoring urine biomarkers related to the development of chronic kidney disease. For example, a normalized time course of approximately fourteen Days measuring urinary proteins can be used to establish the risk of recovery versus non-recovery in patient's having suffered an acute kidney injury. Alternatively, the invention describes signature protein expression profiles to establish the probability of renal to recovery and/or renal non-recovery. | 2013-12-05 |
20130323752 | BLID; a novel protein domain for interaction with the Bcl-2 family of proteins - In this invention, a novel protein interaction domain is provided along with several of its variants. This domain is involved in protein-protein interactions with the Bcl-2 family of proteins. It is named BLID (Bcl2 family of proteins Like Interaction Domain). Use of BLID and its variants for modulating cellular activity is presented. BLID, its variants and or anti-BLID antibodies could be useful as a screening tool as well as for discovery of drugs that help fight pathological states like degenerative diseases, cerebral or cardiac ischemic hypoxic disorders, cancer and autoimmunity. | 2013-12-05 |
20130323753 | METHODS AND KITS FOR IDENTIFICATION OF ANTI-EXCITOTOXIC COMPOUNDS - The instant invention provides methods and kits for screening for anti-excitotoxic compounds which increase the total amount of EAAT-1 protein or the surface amount of EAAT-1 protein. | 2013-12-05 |
20130323754 | Diagnostic Kit as Well as a Metho dfor the Examination of a Human Patient Sample for the Presence of Neuromyelitis Optica-Specific Antibodies - A diagnostic kit as well as a method for the examination of a human patient sample for the presence of neuromyelitis optica-specific antibodies are described, for which an initial substrate is incubated with human sample material, and said incubated initial substrate is examined using indirect immunofluorescence, whether neuromyelitis optica-specific antibodies have at least partially bound to said initial substrate. | 2013-12-05 |
20130323755 | DIAGNOSTIC TUMOR MARKERS, DRUG SCREENING FOR TUMORIGENESIS INHIBITION, AND COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER - The invention provides a series of compositions, methods, kits, articles and species associated primarily with the diagnosis and/or treatment of cell proliferation, specifically cancer. Cell proliferation associated with aberrant expression of MUC1 is particularly focused upon. Mechanisms associated with MUC1 cell proliferation are discussed. | 2013-12-05 |
20130323756 | METHODS AND COMPOSITIONS FOR QUANTIFYING EXOSOMES - Embodiments of the present invention relate to methods, compositions and kits for quantifying exosomes. In particular, methods, composition and kits that utilize lectins to quantify exosomes are provided. | 2013-12-05 |
20130323757 | Method and System for Characterizing the Movement Speed of Particles Contained in a Liquid, such as Blood Particles - The method according to the invention is capable of characterizing a variation in the speed of particles or agglomeration of particles, the particles, such as blood particles, being contained in a liquid ( | 2013-12-05 |
20130323758 | MEASUREMENT DEVICE AND MEASUREMENT METHOD - A measurement device that includes a plurality of lines for conveying a reaction container containing a sample and measures a predetermined material included in the sample while conveying the reaction container by the plurality of lines, wherein the plurality of lines include: a first reaction line for conveying a reaction container at a first convey speed; a second reaction line for conveying a reaction container at a second convey speed; and a measurement line for measuring a predetermined material included in a sample reacted with a reagent within the reaction container in the first reaction line and a sample reacted with a reagent within the reaction container in the second reaction line, the measurement line conveying the reaction containers at a third convey speed that is higher than the first convey speed and the second convey speed. | 2013-12-05 |
20130323759 | SPINAL MUSCULAR ATROPHY DIAGNOSTIC METHODS - The present invention relates to the discovery of the human survival motor-neuron gene or SMD gene, which is a chromosome 5-SMA (Spinal Muscular Atrophy) determining gene. The present invention further relates to the nucleotide sequence encoding the SMN gene and corresponding amino acid sequence, a vector containing the gene encoding the SMN protein or a DNA sequence corresponding to the gene and transformant strains containing the SMN gene or a DNA sequence corresponding to the gene. | 2013-12-05 |
20130323760 | COMPOSITION OF DIAGNOSTIC BIOMARKER FOR STOMACH CANCER AND METHOD OF DIAGNOSING STOMACH CANCER USING THE COMPOSITION - Provided are a composition of a diagnostic biomarker for stomach cancer and a method of diagnosing stomach cancer using the same. The composition of a diagnostic biomarker for stomach cancer and the method of diagnosing stomach cancer using the same may be useful to determine stomach cancer from a patient with suspected stomach cancer. | 2013-12-05 |
20130323761 | BIOMARKERS AND THERAPEUTIC TARGETS FOR TREATING CARDIOMYOPATHIES AND CONGESTIVE HEART FAILURE - In alternative embodiments, the invention provides methods for predicting or diagnosing a heart disease or a defect in cardiac muscle contractility in an individual, or a defect in rate of cardiac muscle twitch relaxation and/or ventricular torsion, or detecting a cardiac trauma, in an individual or in a cardiac cell, or (by testing) a serum or a blood sample. In alternative embodiments, the invention provides methods for screening for a composition that can treat, ameliorate, prevent or reverse a heart disease or a congestive heart failure in an individual, or a defect in cardiac muscle contractility, or a defect in rate of cardiac muscle twitch relaxation and/or ventricular torsion in an individual or a cardiac muscle cell. | 2013-12-05 |
20130323762 | ANTI-IDIOTYPE ANTIBODY AGAINST AN ANTIBODY AGAINST THE AMYLOID BETA PEPTIDE - The present invention is directed to an anti-idiotype antibody binding to the complementary determining region of an antibody against the amyloid β peptide. In one embodiment said antibody binds to the same epitope or an overlapping epitope as the antibody obtainable from the cell line DSM ACC2939. Also reported is an immunoassay for the determination of an antibody against the amyloid β peptide and for determination of an anti-idiotype antibody binding to an antibody against the amyloid β peptide. | 2013-12-05 |
20130323763 | METHOD FOR DIAGNOSING ACUTE LUNG INJURY - The present invention provides a useful examination method and diagnostic reagent, which are capable of diagnosing acute lung injury in clear distinction from chronic progressive interstitial pneumonia. Specifically, the present invention provides a method of determining whether or not a test subject is affected with acute lung injury, which comprises quantifying heat shock protein 47 in a biological sample derived from the test subject. | 2013-12-05 |
20130323764 | ASSAY TEST CARD - The present invention relates to the use of surfaces that exhibit different surface energies wherein the difference in surface energies is configured to disrupt capillary laminar flow of a fluid travelling between the two surfaces. The invention further relates to the use of such surfaces in assay methods including a device utilising same. | 2013-12-05 |
20130323765 | Method For Determining The Activity Of A Proteolytic Coagulation Factor In A Sample - A method for determining the activity of a proteolytic coagulation factor in a sample may include (a) providing and incubating a reaction mixture comprising (i) the sample, (ii) an agent for direct or indirect activation of the proteolytic coagulation factor in the sample, (iii) a cleavable substrate which has at least one cleavage site for the activated coagulation factor, (iv) a solid phase to which the cleavable substrate is bound or becomes bound during the incubation; (b) separating off the solid phase; and (c) determining the amount of solid-phase-bound, uncleaved substrate, wherein the determined amount of solid-phase-bound, uncleaved substrate indicates a quantitative measure of the activity of the proteolytic coagulation factor in the sample. | 2013-12-05 |
20130323766 | Production of Malonyl-CoA Derived Products Via Anaerobic Pathways - The present invention provides for novel metabolic pathways to convert biomass and other carbohydrate sources to malonyl-CoA derived products, such as hydrocarbons and other bioproducts, under anaerobic conditions and with the net production of ATP. More specifically, the invention provides for a recombinant microorganism comprising one or more native and/or heterologous enzymes that function in one or more engineered metabolic pathways to achieve conversion of a carbohydrate source to, e.g., long-chain hydrocarbons and hydrocarbon derivatives, wherein the one or more native and/or heterologous enzymes is activated, upregulated, downregulated, or deleted. The invention also provides for processes to convert biomass to malonyl-CoA derived products which comprise contacting a carbohydrate source with a recombinant microorganism of the invention. | 2013-12-05 |
20130323767 | Method to Identify Liver Toxicity Using Metabolite Profiles - The present disclosure relates to a methodology that identifies the underlying mechanisms that lead to hepatotoxicity. This is done by using the alterations in cellular metabolite profiles obtained before and after therapy/drug treatment in combination with a model of liver metabolism. Subsequently, by using a covariance matrix adaptation followed by evolutionary selection, it compares the drug-induced metabolite profiles obtained experimentally with those generated using the in silico model, automatically shortlists potential parameters whose alterations could have produced the drug-treated metabolite profile. Values of these parameters are estimated by formulating an optimal control problem to minimize the differences between the model-generated metabolite values and experimentally observed data. The estimated parameters are given as an input to the homeostatic liver model and simulations are carried out, thereby the results providing a mechanistic explanation for the development of toxicity. | 2013-12-05 |
20130323768 | CULTURE SUBSTRATE COMPRISING CELLULOSE GEL, SOLID MEDIUM USING SAME, AND CELLULASE ACTIVITY ASSAY METHOD USING MEDIUM - A cellulose gel medium having good visibility of microbial colonies, a cellulose gel culture substrate for manufacturing the cellulose gel medium, a method for manufacturing the cellulose gel culture substrate, a method for screening cellulase-producing microorganisms or cellulase activity with greater efficiency and rapidity, and a culture substrate, which includes a cellulose gel containing cellulose and water as medium-solidifying components, the cellulose has the viscosity of 12 to 35 mPa·S as measured at 26° C. with a solution prepared by dissolving the cellulose at a concentration of 2.5 mg/mL in dimethylacetamide containing 8% (W/V) lithium chloride. | 2013-12-05 |
20130323769 | ENDOPLASMIC RETICULUM CALCIUM ATPASE KINETICS INDICATOR AND USE THEREOF - The present invention provides a fusion protein including sarco/endoplasmic reticulum calcium ATPase, a fluorescence donor for FRET, and a fluorescence acceptor, one of the fluorescence donor and the fluorescence acceptor being linked to the N-terminus side of the ATPase, the other of the fluorescence donor and the fluorescence acceptor being inserted between the above one of the fluorescence donor and the fluorescence acceptor and the ATPase or being inserted in an amino acid sequence of the ATPase, the amino acid sequence corresponding to (i) amino acids 1 through 6 in SERCA2a, (ii) amino acids 369 through 380 in the SERCA2a or (iii) amino acids 572 through 583 in the SERCA2a. | 2013-12-05 |
20130323770 | SUBSTRATES AND METHODS FOR STAINING LIVE STEM CELLS - The invention relates to novel substrates and methods for staining live stem cells. The stain may be used to identify induced pluripotent stem cell colonies during the process of somatic cell reprogramming. | 2013-12-05 |
20130323771 | COPOLYMER-1, PROCESS FOR PREPARATION AND ANALYTICAL METHODS THEREOF - The present invention relates to analytical methods such as molecular weight determination of polypeptide, in particular Glatiramer acetate. The present invention further relates to an improved process for preparation of polypeptides or pharmaceutically acceptable salts thereof, particularly Glatiramer acetate also known as Copolymer-1. The present invention further relates to characterization of Glatiramer acetate by peptide mapping. | 2013-12-05 |
20130323772 | 3-HYDROXYPROPIONIC ACID AND OTHER ORGANIC COMPOUNDS - Methods and materials related to producing 3-HP as well as other organic compounds are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, and methods and materials for producing 3-HP and other organic compounds are disclosed. | 2013-12-05 |