49th week of 2014 patent applcation highlights part 49 |
Patent application number | Title | Published |
20140356825 | METHOD AND SYSTEM FOR QUANTITATIVE ASSESSMENT OF SPATIAL SEQUENCE MEMORY - A method and system are presented to address quantitative assessment of spatial sequence memory in a subject, where the method comprises the steps of: (1) presenting at least one scene to the subject on a display, the scene comprising a plurality of elements and a background; (2) modulating the saliency of a predetermined section of said scene (3) receiving feedback from the subject via at least one input device; (4) modifying the saliency of the predetermined section; (5) adjusting a functional assessment parameter relative to the scene; (6) moving the predetermined section relative to the scene; (7) receiving refined feedback from the subject via the input device; (8) quantitatively refining the refined feedback; (9) calculating a critical threshold parameter for the subject; and (10) recording the critical threshold parameter onto a tangible computer readable medium. | 2014-12-04 |
20140356826 | METHOD AND SYSTEM FOR QUANTITATIVE ASSESSMENT OF WORD IDENTIFICATION LATENCY - A method and system are presented to address quantitative assessment of word identification latency of a subject, where the method comprises the steps of: (1) presenting at least one scene, comprising a plurality of letters and a background, to a subject on a display; (2) moving the plurality of letters relative to the scene; (3) receiving feedback from the subject via the input device; (4) quantitatively refining the received feedback; (5) modulating the movement of plurality of letters relative to accuracy of the quantitatively refined feedback; ((6) calculating a critical threshold parameter; and (7) recording a critical threshold parameter onto a tangible computer readable medium. | 2014-12-04 |
20140356827 | METHOD AND SYSTEM FOR QUANTITATIVE ASSESSMENT OF LETTER IDENTIFICATION LATENCY - A method and system are presented to address quantitative assessment of letter identification latency of a subject, where the method comprises the steps of: (1) presenting at least one scene to a subject on a display, the scene comprising a plurality of letters and a background; (2) moving the plurality of letters relative to the scene, the movement being tracked by the subject via at least one input device; (3) receiving feedback from the subject via the input device; (4) quantitatively refining the received feedback; (5) modulating the movement of plurality of letters relative to accuracy of the received feedback; (6) calculating a critical threshold parameter; and (7) recording a critical threshold parameter onto a tangible computer readable medium. | 2014-12-04 |
20140356828 | METHOD AND SYSTEM FOR QUANTITATIVE ASSESSMENT OF WORD DETECTION LATENCY - A method and system are presented to address quantitative assessment of word recognition sensitivity of a subject, where the method comprises the steps of: (1) presenting at least one scene to a subject on a display, the scene comprising a plurality of letters and a background; (2) distorting the scene; (3) moving plurality of letters relative to the scene, the movement being tracked by the subject via at least one input device; (4) receiving feedback from the subject via the input device; (5) quantitatively refining the received feedback; (6) modulating the movement of plurality of letters relative to accuracy of the received feedback; (7) calculating a critical threshold parameter; and (8) recording a critical threshold parameter onto a tangible computer readable medium. | 2014-12-04 |
20140356829 | METHOD AND SYSTEM FOR QUANTITATIVE ASSESSMENT OF SOCIAL INTERACTIONS NULLING TESTING - A method and system are presented to address quantitative assessment of social interactions nulling testing of a subject, where the method comprises the steps of: (1) presenting at least one scene to the subject on a display, the scene comprising a plurality of body images and a background; (2) receiving feedback from the subject via at least one input device; (3) quantitatively refining the received feedback; (4) modulating the adjusted body image relative to the accuracy of the received feedback; (5) calculating a critical threshold parameter for the subject; (6) recording a critical threshold parameter onto a tangible computer readable medium. | 2014-12-04 |
20140356830 | METHOD AND SYSTEM FOR QUANTITATIVE ASSESSMENT OF FACIAL EMOTION NULLING - A method and system are presented to address quantitative assessment of facial emotion nulling of a subject, where the method comprises the steps of: (1) presenting at least one scene, comprising a single facial expressions and a background, to a subject on a display; (2) adjusting the facial expression on the scene; (3) receiving feedback from the subject via at least one input device; (4) quantitatively refining the received feedback; (5) modulating the adjusted facial expression relative to the accuracy of the quantitatively refined feedback; (6) transforming the modulated facial expression; (7) calculating a critical threshold parameter; and (8) recording a critical threshold parameter onto a tangible computer readable medium. | 2014-12-04 |
20140356831 | METHOD AND SYSTEM FOR QUANTITATIVE ASSESSMENT OF VERBAL RECOGNITION MEMORY - A method and system are presented to address quantitative assessment of verbal memory of a subject, where the method comprises the steps of: (1) presenting at least one scene to the subject on a display, the scene comprising a plurality of symbols and a background; (2) moving the plurality of symbols relative to the scene, the movement being tracked by the subject via at least one input device; (3) adjusting the saliency of the plurality of symbols relative to the tracked movement; (4) increasing the number of said plurality of symbols; (5) receiving feedback from the subject via said input device; (6) quantitatively refining the received feedback; (7) modulating the movement of the plurality of symbols relative to the accuracy of the quantitatively refined feedback; (8) calculating a critical threshold parameter; and (9) recording a critical threshold parameter onto a tangible computer readable medium. | 2014-12-04 |
20140356832 | METHOD AND SYSTEM FOR QUANTITATIVE ASSESSMENT OF FACIAL EMOTION NULLING - A method and system are presented to address quantitative assessment of facial emotion nulling of a subject, where the method comprises the steps of: (1) presenting at least one scene, comprising a single facial expressions and a background, to a subject on a display; (2) adjusting the facial expression on the scene; (3) receiving feedback from the subject via at least one input device; (4) quantitatively refining the received feedback; (5) modulating the adjusted facial expression relative to the accuracy of the quantitatively refined feedback; (6) transforming the modulated facial expression; (7) calculating a critical threshold parameter; and (8) recording a critical threshold parameter onto a tangible computer readable medium. | 2014-12-04 |
20140356833 | GENERATING INFORMATION RELATING TO A COURSE OF A PROCEDURE - A system for generating information relating to a course of a procedure is described. A current position determiner ( | 2014-12-04 |
20140356834 | Device to Record Competence - A medical training system is disclosed comprising a medical sensor, a student record database having a plurality of records relating to training of students, wherein the student record database is connectable to a medical sensor for monitoring medical procedures on a patient; and a data entry device for entry of student performance data to the student record database, the student performance data being indicative of performance of the students on at least one medical procedure. | 2014-12-04 |
20140356835 | CLINICAL SIMULATION DEVICE - A dental simulator includes a base and a platform connected to the base. The base has a first end, an opposing second end, and a longitudinal axis extending from the first end toward the second end. The platform has at least a first portion which is movably connected to the base. The first portion of the base also includes at least one actuator. The simulator further includes a torso support movably connected to the base and at least a first instrument holder movably connected to the base. At least the first portion of the platform, the torso support, and the first instrument holder are configured to move in unison with respect to the base along the longitudinal axis thereof. | 2014-12-04 |
20140356836 | MODEL NEWBORN HUMAN EYE AND FACE MANIKIN - A model newborn human eye which includes a hemispherical-shaped, integrally molded top assembly comprising a visually transparent cornea portion surrounding a visually opaque sclera portion in combination with a hemispherical-shaped bottom assembly comprising a bowl-shaped substrate disposed therein. The model newborn human eye further comprises a retinal layer comprising a two dimensional image of retinal vasculature disposed on said substrate, where the model newborn human eye is dimensioned for diagnosing Retinopathy of Prematurity (“ROP”) in premature infants. | 2014-12-04 |
20140356837 | SYSTEM AND METHOD FOR GENERATING AN INTERACTIVE LEARNING MAP ON LEARNING MANAGEMENT PLATFORM - Disclosed is a system and method for enabling a student to achieve a proficiency level in a first learning grade on a learning management platform. A learning map generator is configured to generate an interactive learning map comprising a plurality of nodes on the learning management platform. The learning map generator is configured to form a layer comprising a first content object and a first assessment object on a first node of the plurality of nodes. Further, the learning map generator is configured to selectively embed on the first layer a plurality of content objects and a plurality of assessment objects from a Data Store using a recommendation engine. A visualization engine is configured to display the interactive learning map to the student and an instructor. The instructor evaluates the performance of the student accessing and attempting the plurality of content objects and the plurality of assessment objects respectively on the interactive learning map. | 2014-12-04 |
20140356838 | Education Game Systems and Methods - The present disclosure provides education game systems and methods that display test problems including answer options, wherein the systems and methods enable a user to drag the answer options from the test problem to an answer receiving location to improve the user's test taking skills, thereby improving their overall score on standardized exams. | 2014-12-04 |
20140356839 | METHOD AND SYSTEM FOR DEVELOPING PROCESS, PROJECT OR PROBLEM-BASED LEARNING SYSTEMS WITHIN A SEMANTIC COLLABORATIVE SOCIAL NETWORK - The system provides a framework for developing process, project or problem-based learning systems that make use of social networking. The system provides a general purpose framework to create, manage, and deliver online instruction that supports learning methods consistent with social constructivist and experiential learning theories. The framework utilizes personal social software for collaboration, problem-solving, group work, and other activities consistent with those methods. The general framework, based on finite-state automata and other methods for determining similarity of learning objectives, provides individual creators the means to define, implement, and manage experiential instruction within a social network. | 2014-12-04 |
20140356840 | COLLABORATIVE AND INTERACTIVE LEARNING - The present invention helps generate connected communities of students and educators through access to an increased pool of granular learning resources that benefit from standardization of formats for creating and utilizing individual discussions on individual topics. The present invention also circumvents the complexity of existing repository systems by creating a standard platform format. Because this format is de facto implemented for any educator using the platform, standardized question types (e.g., discussion types or topic types) become functionally interchangeable notwithstanding any particular individuals utilizing the invention. The interchangeability of individual topics allows for creation of a global “topic library,” which may be made available to any educator using the system. This global topic library contains the standardized questions or discussion topics thereby allowing for quick review, selection, and incorporation into the individual teaching environment of any teacher utilizing the invention. | 2014-12-04 |
20140356841 | METHOD AND SYSTEM FOR QUANTITATIVE ASSESSMENT OF FUNCTIONAL IMPAIRMENT - A method and system is presented to address quantitative assessment of functional impairment in a subject, comprising: presenting a plurality of tests to a subject on a display, the tests comprising a series of scenes, the scene comprising at least one stimulus, wherein the scene may be associated with visual, auditory, and tactile stimulus arrays; modulating at least one spatial characteristic of at least one stimulus; receiving feedback from the subject via at least one input device; quantitatively refining the scene relative to the received feedback; calculating the relationship between at least one of the scene, the stimulus, and the quantitatively refined scene; adjusting the scene relative to the calculated relationship; determining equilibrated scene parameter of the subject; recording the equilibrated scene parameter onto a tangible computer readable medium; generating at least one diagnosis to the functional impairment associated with the equilibrated scene parameter; recommending treatment to the subject. | 2014-12-04 |
20140356842 | METHOD AND SYSTEM FOR QUANTITATIVE ASSESSMENT OF VISUAL MOTOR RESPONSE - A method and system are presented to address quantitative assessment of visual motor response in a subject, where the method comprises the steps of: (1) presenting at least one scene to a subject on a display; (2) modulating the contrast of a predetermined section of the scene; (3) moving the predetermined section relative to the scene with the movement being tracked by the subject via at least one input device; (4) measuring a kinematic parameter of the tracked movement; (5) quantitatively refining the tracked movement; (6) determining the relationship between at least one of the scene and the quantitatively refined tracked movement; (7) adjusting the modulated contrast relative to the quantitatively refined tracked movement; (8) calculating a critical threshold parameter for the subject; and (9) recording a critical threshold parameter onto a tangible computer readable medium. | 2014-12-04 |
20140356843 | PORTABLE APPARATUS AND SCREEN DISPLAYING METHOD THEREOF - A screen displaying method in a portable apparatus includes displaying a personal screen of an application executed by the portable apparatus in response to input user identification information; detecting a touch on the personal screen; and controlling the personal screen in response to the touch to display a second screen, wherein the second screen includes at least a portion of a common screen which is a screen of an external device connectable through a network. | 2014-12-04 |
20140356844 | COLLABORATIVE LEARNING PLATFORM FOR GENERATING AND PRESENTING CONTEXT-ORIENTED CONTENT ON AN ELECTRONIC DEVICE - The embodiments herein disclose a system and method for presenting a context-oriented content from a plurality of information sources. The method includes receiving a request from an electronic device for the context-oriented content associated with an item of a particular object. Further, the method includes identifying the context-oriented content associated with the item from the plurality of information sources. Furthermore, the method includes generating an overlay framework layers including context-oriented content. Furthermore, the method includes presenting the overlay framework layers associated with the item within the particular object to the user on an electronic device. | 2014-12-04 |
20140356845 | SYSTEM AND METHOD FOR DISTRIBUTED ONLINE EDUCATION - A method for online distributed education comprising, receiving a course materials from a teacher at a processor, publishing a course based on the course materials to a plurality of students using the processor, receiving at least one registration from a first student in the plurality of students to the course at the processor, publishing a customized course experience to the first student using the processor, the first student completing the course, and the first student teaching the course to at least one student in the plurality of students. | 2014-12-04 |
20140356846 | APPARATUS, SYSTEMS AND METHODS FOR INTERACTIVE DISSEMINATION OF KNOWLEDGE - Embodiments of apparatus, systems and methods facilitate knowledge dissemination and promote knowledge acquisition, in part, by automatically presenting elements of an interlinked knowledge base to optimize learning efficiency. In some embodiments, a graphical user interface (GUI) facilitates user interaction with subject items, ordered arrangements of subject items, and display of subject items and their interconnections in the knowledge base. For example, the GUI facilitates operations such as the determination and display of: subject items with the same subject tag, and subject items with similar connectivity. Other operations facilitate simplification and modification of the displayed knowledge graph comprising the subject items. | 2014-12-04 |
20140356847 | Learning Tool - A learning device has been described. The components of the system and methods of use are included. The device has been shown to be generally useful in providing organizational structure and memory techniques to enhance learning in a variety of subject areas. In one embodiment the device is made from printed erasable card stock. In another embodiment the learning device is incorporated into a program that controls a computing device to display and enable interaction with the learning device as shown on a display. In yet another embodiment the device is projected on a wall or screen using a computer and a projector. | 2014-12-04 |
20140356848 | METHODS AND SYSTEMS FOR ARRANGING MEDIA OBJECTS ON A DISPLAY SCREEN TO COMPENSATE FOR USER DISABILITIES - Methods and systems are disclosed herein for arranging media objects on a display screen to compensate for disabilities of a user. For example, if a media guidance application determines that, based on a particular disability, a user cannot see (or has limited vision with respect to) a portion of a screen displaying a media asset, the media guidance application alters the arrangement of media objects in the media asset to compensate for the disability. | 2014-12-04 |
20140356849 | INTEGRATED ORGAN-ON-CHIP SYSTEMS AND APPLICATIONS OF THE SAME - In one aspect of the invention, an integrated bio-object microfluidics chip includes a fluidic network having a plurality of inlets for providing a plurality of fluids, a plurality of outlets, a bio-object chamber for accommodating at least one bio-object, a plurality of fluidic switches, and one or more pumps, coupled to each other such that at least one fluidic switch operably and selectively receives one fluid from a corresponding inlet and routes the received fluid, through the one or more pumps, to the bio-object chamber so as to perfuse the at least one bio-object therein, and one of the downstream fluidic switches selectively delivers an effluent of the at least one bio-object responsive to the perfusion to a predetermined outlet destination, or to the at least one fluidic switch for recirculation. | 2014-12-04 |
20140356850 | APPARATUS FOR OXYGENATION AND PERFUSION OF TISSUE FOR ORGAN PRESERVATION - Systems and methods of the invention generally relate to prolonging viability of bodily tissue in static cold storage and hypothermic machine perfusion techniques by reducing the rate of edema through the application of compressive force to the bodily tissue via a compression device. Compression devices of the invention may comprise biocompatible materials and may apply compressive force through incorporation of elastic materials, through expandable bladders, or other means. Certain embodiments include perfusion devices comprising a pneumatic system, a pumping chamber, and an organ chamber. The pumping chamber is configured to diffuse a gas into a perfusate and to generate a pulse wave for moving the perfusate through a bodily tissue. The organ chamber is configured to receive the perfusate along with a bodily tissue fitted with a compression device. Both the organ chamber and the pumping chamber are configured to substantially automatically purge excess fluid. | 2014-12-04 |
20140356851 | System and Method for the Re-Anticoagulation of Platelet Rich Plasma - A method for the re-anticoagulation of platelet rich plasma in a blood apheresis system includes priming the blood apheresis system with anticoagulant, such that a volume of anticoagulant is transferred to a PRP container. The method may then transfer the anticoagulant within the PRP container to a red blood cell container, and collect a volume of platelet rich plasma within the PRP container. The platelet rich plasma may be collected in a plurality of cycles. Between collection cycles, the method may transfer a portion of the volume of anticoagulant from the red blood cell container to the PRP container. | 2014-12-04 |
20140356852 | SYSTEM AND METHOD FOR MICRO-AERATION BASED FERMENTATION - A method and apparatus for micro-aeration of large scale fermentation systems is provided. The micro-aeration system includes a fermentation reactor, a sparging apparatus, and a micro-aeration gas mixture delivered to the fermentation reactor via the sparging apparatus. The micro-aeration gas mixture is a very low oxygen concentration mixture comprising: (i) an oxygen containing gas; and (ii) an inert carrier gas or reactive carrier gas that is recycled through the fermentation reactor. The gas mixture is introduced to the fermentation reactor at a minimum superficial velocity of about 0.04 m/sec to produce a uniform dispersion of the oxygen throughout the fermentation broth while concurrently mixing the entire fermentation broth. For a reactive gas consuming fermentation process, the amount of reactive carrier gas included as part of the gas mixture exceeds the reaction stoichiometric requirements in order to provide sufficient dispersion and agitation of the broth. | 2014-12-04 |
20140356853 | AUTOMATED NUCLEIC ACID ANALYSIS SYSTEM - A nucleic acid analysis system comprising a seating area configured to receive a microfluidic cartridge; a pneumatic module configured to supply a pneumatic pressure or a vacuum to the cartridge when mounted on the seating area; a thermal module configured to control temperature in a predetermined portion of the cartridge when mounted on the seating area; an optic module positioned to irradiate light onto the cartridge when mounted on the seating area, and detect light generated or reflected from a sample inside the cartridge when mounted on the seating area; a fluid sensing module that determines whether a fluid in a predetermined portion of a cartridge mounted on the seating area is in a gaseous state or a liquid state; a scanning module that moves the optic module and the fluid sensing module relative to the seating area; and a control module that controls operations of the pneumatic module, the thermal module, the optic module, the fluid sensing module, and the scanning module, and processes and analyzes data received therefrom. | 2014-12-04 |
20140356854 | METHODS AND COMPOSITIONS RELATING TO MEVALONATE PHOSPHATE DECARBOXYLASE - Methods and compositions related to a novel mevalonatephosphate decarboxylase enzymes are provided. The methods and compositions provided herein are particularly useful for the synthesis of isopentyl phosphate. The compositions and methods provided herein may also be used in combination with isopentyl phosphate kinase for the synthesis of isopentyl diphosphate. | 2014-12-04 |
20140356855 | METHODS OF DIAGNOSING A DISEASE AND METHODS OF MONITORING TREATMENT OF A DISEASE BY QUANTIFYING A NON-REDUCING END GLYCAN RESIDUAL COMPOUND AND COMPARING TO A SECOND BIOMARKER - Provided herein are methods of diagnosing or monitoring the treatment of abnormal glycan accumulation or a disorder associated with abnormal glycan accumulation. | 2014-12-04 |
20140356856 | Method for Manufacturing and Using a Test Paper and Chemical Composition Thereof - A method for manufacturing a test paper is disclosed in the present invention, and at least comprises the following steps. First, a chemical precursor comprising at least a reducing agent is coated onto a substrate. The substrate is then dipped into a metal salt solution comprising a plurality of metal ions for a predetermined time to reduce the metal ions to form metal particles on the substrate. Finally, the substrate is taken out and dried to complete a manufacture of at least a test paper. In the meantime a method for using the test paper, and a chemical composition used in the abovementioned for manufacturing the test paper are also disclosed in the present invention. | 2014-12-04 |
20140356857 | INTERPARTICLE SPACING MATERIAL INCLUDING NUCLEIC ACID STRUCTURES AND USE THEREOF - Provided is an interparticle spacing material comprising a nucleic acid structure which comprises at least one nucleic acid lattice comprising a double helix domain; and at least one metal particle which is in contact with a plane of the nucleic acid lattice, in a direction extending obliquely or perpendicularly away from the plane; wherein the double helix domain comprises a hybridization area in which a single strand is hybridized with another single strand. | 2014-12-04 |
20140356858 | Biological Tag Tracking of Agricultural Products, Foods, and Other Items - The disclosure relates to compositions and methods for applying a biological tag to a product and detection of the biological tag on the product by another. The compositions and methods are useful for tracing the provenance of a product, such as a food product or an agricultural product. | 2014-12-04 |
20140356859 | DETECTION OF NUCLEIC ACIDS USING UNMODIFIED GOLD NANOPARTICLES - A gold nanoparticle-based colorimetric assay kit for nucleic acids from viral, bacterial and other microorganisms that detects unamplified or amplified polynucleotides in clinical specimens using unmodified AuNPs and oligotargeter polynucleotides that bind to a pathogen's nucleic acids. A method for detecting a pathogen comprising contacting a sample suspected of containing microbes with a polynucleotide that binds to pathogen nucleic acid and with gold nanoparticles, detecting the aggregation of nanoparticles, and detecting pathogen polynucleotides in the sample when the nanoparticles aggregate (solution color becomes blue) in comparison with a control or a negative sample not containing the virus when nanoparticles do not aggregate (solution color remains red). | 2014-12-04 |
20140356860 | METHOD FOR ISOLATING NUCLEIC ACIDS FROM A VETERINARY WHOLE BLOOD SAMPLE - The present invention provides a method for isolating nucleic acids from a veterinary whole blood sample, said method comprising at least the following steps a) preparing a binding mixture comprising—the lysed sample—at least one chaotropic agent—at least one alcohol—at least one polyoxyethylene fatty alcohol ether; b) passing the binding mixture through a column comprising a nucleic acid binding solid phase thereby binding the nucleic acids to the nucleic acid binding solid phase; c) optionally washing the nucleic acids while being bound to the solid phase; d) optionally eluting the nucleic acids from the solid phase. It was found that the addition of the specific non-ionic detergent overcomes the problems of the prior art methods, wherein the column clogs what prevents the efficient nucleic acid isolation from this difficult sample. When the specific non-ionic detergent is included into the binding mixture, no clogging occurs thereby allowing the efficient isolation of nucleic acids from veterinary whole blood samples. | 2014-12-04 |
20140356861 | METHOD FOR CHECKING THE SELF-HEALING PROCESS CARRIED OUT BY THE IMMUNE SYSTEM OF A TEST SUBJECT INFECTED WITH HUMAN PAPILLOMA VIRUS - A method and device for checking the self-healing process carried out by the immune system of a test subject infected with human papillomavirus (HPV) using one or more cell-containing samples taken from the test subject, to prevent the formation of an HPV-induced carcinoma. The method involves: (1) determining whether HPV with at least one HPV-specific stimulus molecule, stimulating the test subject's immune system, is contained in at least one of the samples; (2) determining whether innate HPV antibodies with the stimulus molecule are in the sample or at least one of the other samples; (3) analyzing results from (1) and (2) to determine whether the self-healing process has started based on the presence of the stimulus molecule and/or the antibodies. | 2014-12-04 |
20140356862 | SYSTEM FOR ON-LINE MONITORING AND CONTROLLING OF CHEMICAL REACTIONS IN REACTORS - The application describes an MRD-based reactor. The reactor is characterized by a continuous wall portion, and is in connection with a MRD, adapted for performing localized NMR spectroscopy of the medium inside the reactor. MRD-based reactors, in which the MRD is at least partially inside the reactor or reaction media, and those in which the MRD accommodates the reactor, are also introduced. Lastly, the invention teaches an in situ method for controlling and analyzing of a reaction. The method makes use of an MRD-based reactor; and comprises applying a magnetic field within the reactor, especially for performing a plurality of localized spectroscopic measurements and either real time or offline analyzing and/or controlling of reactions in the flowing media. | 2014-12-04 |
20140356863 | METHODS FOR DETERMINING THE SUSCEPTIBILITY OF A VIRUS TO AN ATTACHMENT INHIBITOR - The present invention provides novel compositions and methods that can be used for determining the susceptibility of virus to an attachment inhibitor. The present invention also provides methods for predicting whether an infected individual will respond to treatment with an attachment inhibitor, thereby allowing an effective treatment regimen to be designed without subjecting the patient to unnecessary side effects. | 2014-12-04 |
20140356864 | ANALYSIS OF COLORIMETRIC OR FLUOROMETRIC TEST ASSAYS - The present invention provides for the analysis of colorimetric or fluorometric assays by way of capturing an image of the assay on the camera ( | 2014-12-04 |
20140356865 | Methods and Compositions for Efficient Base Calling in Sequencing Reactions - The present invention is directed to methods and compositions for acquiring nucleotide sequence information of target sequences. In particular, the present invention provides methods and compositions for improving the efficiency of sequencing reactions by using fewer labels to distinguish between nucleotides and by detecting nucleotides at multiple detection positions in a target sequence. | 2014-12-04 |
20140356866 | COMPUTER READABLE MEDIUM FOR ENABLING A COMPUTER TO CARRY OUT PROVISION OF INFORMATION ON COLON CANCER AND MARKER AND KIT FOR OBTAINING INFORMATION ON COLON CANCER - The present invention is to provide a computer readable medium comprising a computer program for enabling a computer to carry out provision of information on colon cancer in a subject based on an analysis result on methylation status of a novel marker specific for colon cancer. | 2014-12-04 |
20140356867 | NUCLEIC ACID ENRICHMENT USING CAS9 - A method of enriching for a fragment of a genome, as well as corresponding compositions and kits, are provided. In certain embodiments, the method comprises: (a) contacting a sample comprising fragmented DNA with a Cas9-gRNA complex comprising mutant Cas9 protein that has inactivated nuclease activity and a Cas9-associated guide RNA that is complementary to a site in the DNA, to produce a Cas9-fragment complex that comprises a fragment of the fragmented DNA; and (b) isolating the complex. In addition, other methods and compositions for Cas9/CRISPR-mediated nucleic acid manipulation are also provided. | 2014-12-04 |
20140356868 | MACC1 AS A PROGNOSTIC BIOMARKER FOR HEPATOBILIARY TUMORS - The present invention is directed to a method of diagnosis and prognostication of a hepatobiliary tumor, the method comprising the step of determining expression of MACC1 polypeptide or of a nucleic acid encoding said MACC1 polypeptide in a biological sample. | 2014-12-04 |
20140356869 | SINGLE NUCLEOTIDE POLYMORPHISMS ASSOCIATED WITH DIETARY WEIGHT LOSS - The present invention relates to genetic polymorphisms associated with obesity and obesity-related phenotypes and their use in predicting if an individual looses weight during a dietary weight loss intervention program. | 2014-12-04 |
20140356870 | METHOD FOR TRANSCRIPTIONAL AMPLIFICATION OF NUCLEIC ACIDS COMBINING STEPS OF DIFFERENT TEMPERATURES - A method of transcriptional amplification includes: (a) obtaining a mixture by combining (i) a biological sample comprising nucleic acids, (ii) amplification primers, (iii) amplification reagents including enzymes required for amplification, and (iv) at least one polyol capable of stabilizing the enzymes required for amplification; (b) denaturing the nucleic acids by heating the mixture at a temperature above 41° C.; and (c) transcriptionally amplifying at least one target nucleic acid at a temperature above 41° C. when present in the mixture. | 2014-12-04 |
20140356871 | DIAGNOSTIC TESTS FOR THE DETECTION OF INHERITED PERIPHERAL NEUROPATHIES - The disclosure relates to the field of human genetics, particularly the field of peripheral neuropathy, particularly inherited peripheral neuropathy. Specifically, the disclosure relates to methods and materials to detect hereditary peripheral neuropathy, more particularly autosomal recessive Charcot-Marie-Tooth disease. | 2014-12-04 |
20140356872 | HOMOLOGOUS PAIRING CAPTURE ASSAY AND RELATED METHODS AND APPLICATIONS - A Homologous Pairing Capture Assay is described which enables detection of coalignment between homologous DNA sequences. The assay involves ligating closely positioned homologous sequences to each other thereby generating head-to-head ligation products or inverted repeats. DNA fragments containing an inverted repeat are then converted into hairpin DNA molecules. The hairpin DNA molecules can then be readily separated from DNA molecules free of inverted repeats. Also described are various diagnostic applications and kits relating to the assay. | 2014-12-04 |
20140356873 | Derivatives of 1,2-dihydro-7-hydroxyquinolines Containing Fused Rings - The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic rings. Many of the dyes of the invention are useful fluorescent dyes. The invention includes chemically reactive dyes, dye-conjugates, and the use of such dyes in staining samples and detecting ligands or other analytes. | 2014-12-04 |
20140356874 | METHODS AND APPARATUS FOR POINT-OF-CARE NUCLEIC ACID AMPLIFICATION AND DETECTION - Methods and apparatus are provided for point-of-care nucleic acid amplification and detection. One embodiment of the invention comprises a fully integrated, sample-to-answer molecular diagnostic instrument that optionally may be used in a multiplexed fashion to detect multiple target nucleic acid sequences of interest and that optionally may be configured for disposal after one-time use. The instrument preferable utilizes an isothermal nucleic acid amplification technique, such as loop-mediated isothermal amplification (LAMP), to reduce the instrumentation requirements associated with nucleic acid amplification. Detection of target amplification may be achieved, for example, via detection of a color shift or fluorescence in a dye added to the amplification reaction. Such detection may be performed visually by an operator or may be achieved utilizing an imaging technique, e.g., spectrophotometric imaging. | 2014-12-04 |
20140356876 | SYSTEMS AND METHODS FOR IMAGING AND PROCESSING TISSUE - In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest across a portion of the tissue, imaging a plurality of layers of the tissue in a plurality of volumes of the tissue in the region of interest, sectioning the portion of the tissue, capturing the sectioned tissue, and imaging a second plurality of layers of the tissue in a second plurality of volumes of the tissue in the region of interest, and capturing each sectioned tissue, detecting a fluorescence image of the tissue due to said excitation light; and processing three-dimensional data that is collected to create a three-dimensional image of the region of interest. Further, captured tissue sections can be processed, re-imaged, and indexed to their original location in the three dimensional image. | 2014-12-04 |
20140356877 | NUCLEIC ACID SAMPLE PREPARATION - The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples. | 2014-12-04 |
20140356878 | Primers and Methods for Determining RhD Zygosity - Provided herein are primers comprising a nucleotide sequence complementary to a portion of a RhD gene. Also provided herein are methods of determining a RhD zygosity in a subject. Also provided are methods of detecting a weak D allele in a subject. Further provided are kits for determining an RhD zygosity. | 2014-12-04 |
20140356879 | GENES CONFERRING TOLERANCE TO ETHANOL AND HIGH TEMPERATURE FOR YEASTS - Methods of identifying genes conferring ethanol tolerance in yeasts, genes that confer ethanol tolerance, and mutant strains used to identify such genes are described. A gene herein designated HpETT1 was isolated from the yeast | 2014-12-04 |
20140356880 | APPARATUS FOR AUTOMATED DETERMINING OF AT LEAST TWO DIFFERENT PROCESS PARAMETERS - An apparatus for automated determining of at least two different process parameters of a process liquid of a process, especially a bioprocess, comprising: a first measuring cell, which is embodied to provide a first measurement signal dependent on a first process parameter of a first sample of the process liquid; a second measuring cell, which is embodied to provide a second measurement signal dependent on a second process parameter of a second sample of the process liquid; and a control and evaluation system, which serves for monitoring and/or controlling the process, and which is embodied to receive and to process the first and second measurement signals, especially based on the first measurement signal to determine a measured value of the first process parameter and based on the second measurement signal to determine a measured value of the second process parameter; wherein the first measurement signal and the second measurement signal serve different functions in the context of the monitoring and/or controlling of the process. The first process parameter can be a control parameter (critical process parameter, CPP), and the second process parameter can be a product quality parameter (critical quality attribute, CQA) of the process. | 2014-12-04 |
20140356881 | INSPECTION INSTRUMENT, INSPECTION SYSTEM, AND INSPECTION METHOD - With an inspection instrument in which an optical window is disposed so as to enable optical detection in a sample holder, an analysis involving use of a three-order nonlinear Raman scattering microscope, a treatment with an agent, such as staining, and an analysis involving use of a normal optical microscope are serially carried out without opening and closing of the inspection instrument. Thus, in addition to reference information based on result of analysis of a stained sample, more multiple pieces of auxiliary information related to the morphological or functional characteristics of the sample can be obtained from the sample while the reliability of comparison thereof with the reference information is well maintained. | 2014-12-04 |
20140356882 | NON-INVASIVE ENZYME SCREEN FOR TISSUE REMODELLING-ASSOCIATED CONDITIONS - Methods and kits for diagnosing the presence of and prognosing the appearance of tissue remodelling-associated conditions, involving the presence of enzyme complexes in a biological sample, are disclosed. In particular, the method pertains to diagnosing the presence of or prognosing appearance of metastatic cancer by the identification of high molecular weight enzyme complexes comprising MMPs. | 2014-12-04 |
20140356883 | METHOD FOR EVALUATING THE SENSITIVITY AND SPECIFICITY OF FAST MALARIA- DIAGNOSIS TEST KITS - The invention relates to a method for evaluating kits for rapid diagnosis of malaria, in order to determine or to test the sensitivity and specificity thereof. To that end, the reactive strips of the diagnostic kits are exposed to different concentrations of the malaria parasite in a method that allows data on sensitivity and specificity indicated on the technical sheet of the kit to be ascertained. | 2014-12-04 |
20140356884 | Boundary Layer Suction for Cell Capture - Capturing particles includes introducing a fluid sample, which includes particles of a first type, into a first channel of a microfluidic device and flowing the fluid sample past a porous or partially porous membrane. The pores fluidly connect the first channel to a second channel, and the device further includes multiple binding moieties on a first side of the porous membrane adjacent to the first channel. The binding moieties are capable of binding to the first type of particles. Capturing particles also includes creating a pressure difference between the first and second channels to enable the fluid sample to flow from the first channel through the porous membrane into the second channel and to direct the particles toward the binding moieties, thereby capturing the first type of particles. In addition, by creating a modified capture surface that is impermeable near the walls of the channels, capture efficiencies and throughput can be increased. | 2014-12-04 |
20140356885 | Reducing Non-Specifically Bound Molecules on Supports - Methods and reagents are disclosed for preparing a support for reaction of the support with an assay molecule. In the method the support is treated with a detergent at a concentration of about 0.01% to about 5% (by weight) at a temperature of about 4° C. to about 50° C. for a period of about 1 hour to about 24 hours and subsequently the support is washed. The support is contacted with the assay molecule under conditions for covalently binding the assay molecule to the support to form a conjugate of the support and the assay molecule. | 2014-12-04 |
20140356886 | METHOD FOR MEASURING BETA-GLUCAN, AND BETA-GLUCAN-BINDING PROTEIN FOR USE IN THE METHOD - Disclosed are a method for measuring βG comprising the steps of bringing a sample into contact with a βG-binding protein 1 and a βG-binding protein 2, each comprising an amino acid sequence which is identical or substantially identical to an amino acid sequence shown in any one of SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, or SEQ ID NO:20, and having the β-glucan binding activity, to form a complex of the βG-binding protein 1, βG in the sample and the βG-binding protein 2, measuring quantity of the complex, and determining βG concentration in the sample based on the quantity of the complex; a reagent and a kit for use in said method; a novel βG-binding protein; a nucleic acid molecule encoding the βG-binding protein; and a method for producing the aforementioned βG-binding protein. | 2014-12-04 |
20140356887 | GLUCOSE DEHYDROGENASE - Amino acid mutation(s) can be introduced to | 2014-12-04 |
20140356888 | METHOD OF DETECTING A SALMONELLA MICROORGANISM - A method of detecting a | 2014-12-04 |
20140356889 | COMPOSITION FROM LOBSTER HEMOCYTE EXTRACTS FOR DETECTION OF LIPOPOLYSACCHARIDES, PEPTIDOGLYCANS AND 1,3-BETA-D-GLUCANS - The present invention relates to the pharmaceutics, biotechnological and chemical, and particularly to a process for preparing a composition for detecting and measuring the concentration of endotoxins or lipopolysaccharides, peptidoglycans and (1,3)-β-D-glucans, using an extract from the hemocytes of the lobster as a starting material, the changes to the composition to increase the sensitivity, and processes for measuring endotoxins, peptidoglycans and (1,3)-β-D-glucans using said composition. | 2014-12-04 |
20140356890 | METHOD OF RE-COLLECTING TARGET MATERIAL - A method of re-collecting a target material using a filter is provided. The method includes reversely flowing a first fluid from a first flow channel towards a second flow channel through a filter unit so that the target material is included in the first fluid that flows through the second flow channel, wherein the filter includes: the first flow channel, the second flow channel that at least in part overlaps the first flow channel and is disposed above the first flow channel, and the filter unit that is disposed on a region where the first flow channel overlaps the second flow channel and where the target material is captured. | 2014-12-04 |
20140356891 | Determining the Dynamic State of Analytes by Magnetic Flow Measurement - Devices and methods for magnetic flow measurement are provided. Individual analytes are detected in the through-flow, and a dynamic detection of a changing analyte state is carried out, for example with respect to the analyte size or morphology. For this purpose, the analytes to be detected, such as cells for example, are directly marked in the medium surrounding said analytes with magnetic labels and transported through the flow channel of a measuring device comprising at least two magnetic sensors. A characteristic measurement signal is generated by means of the magnetic sensors that are mutually spaced in the flow direction. The magnetic analyte diameter is calculated using the interval between the measurement deflections, and the analyte state can be evaluated using the magnetic analyte diameter. | 2014-12-04 |
20140356892 | Optical Stimulation Device - In an aspect of the disclosure, a stimulation device includes a probe attached to a first support. The probe includes at least one grating coupler for coupling light into the probe. The device further includes at least one optical source for providing an optical stimulation signal mounted on a second support, and at least one means for detachably attaching the first support to the second support. The position of the at least one optical source is aligned with the position of the at least one grating coupler to allow light emitted from the at least one optical source to be received by the at least one grating coupler. | 2014-12-04 |
20140356893 | COMPOSITIONS AND METHODS FOR USING PLATELET-RICH PLASMA FOR DRUG DISCOVERY, CELL NUCLEAR REPROGRAMMING, PROLIFERATION OR DIFFERENTIATION - Methods are described for using compositions containing platelet-rich plasma for the treatment of a variety of tissue lesions, and the use of compositions containing platelet-rich plasma to accelerate or complete the differentiation of a cell line. Particularly, use of platelet-rich plasma in conjunction with cell differentiation. | 2014-12-04 |
20140356894 | SITE-SPECIFIC ORTHOGONAL LABELING OF THE CARBOXY TERMINUS OF ALPHA-TUBULIN IN LIVE CELLS - A technique is provided to visualize microtubules in live cells that does not require genetic manipulation or microinjection. Moreover, this method also avoids perturbation of the endogenous microtubule network that occurs with taxol treatment. This technique exploits tyrosination and detyrosination of tubulin, a posttranslational modification cycle specific to the C-terminus of α-tubulin. Specifically, cells are grown in medium supplemented with a tyrosine derivative possessing a reactive functional group. The cellular enzyme tubulin tyrosine ligase attaches the unnatural amino acid to a single site on tubulin. Addition of fresh medium containing a suitably derivatized fluorophore then yields fluorescent tubulin, which incorporate into cellular microtubules. Importantly, the tubulin labeling approach demonstrated here does not detrimentally affect microtubule network or cell morphology. Thus we present a simple, robust labeling technique that allows microscopic analysis of microtubules in live cells. | 2014-12-04 |
20140356895 | BACTERIA ANALYZING METHOD AND SPECIMEN ANALYZER - Disclosed is a bacteria analyzing method comprising: irradiating with light a measurement sample prepared by mixing a specimen and a reagent; obtaining two types of optical information from each of at least some particles contained in the measurement sample; and generating a measurement result of the specimen with a flag representing morphological characteristics of bacteria contained in the specimen based on both of: (i) information indicative of a characteristic of a distribution pattern of particles plotted in a first region of a coordinate space including at least two axes, wherein the two types of optical information are scalable along the respective axes, and (ii) information representing a number of particles plotted in a second region being a part of the first region. | 2014-12-04 |
20140356896 | Transmembrane Protein as Biosensors - The disclosure relates to engineered transport proteins comprising at last one fluorescent reporter covalently bound to the transporter protein, wherein the transporter proteins comprise a structural inverted repeat motif, with the motif comprising a first and second subunit that are structural inverted repeats of one another and that are joined to one another by a polypeptide loop. | 2014-12-04 |
20140356897 | IN VIVO LABEL-FREE HISTOLOGY BY PHOTOACOUSTIC MICROSCOPY OF CELL NUCLEI - The present disclosure is directed to methods of non-invasively imaging cell nuclei. More particularly, the present disclosure is directed to methods of imaging cell nuclei in vivo using ultraviolet photoacoustic microscopy (UV-PAM), in which ultraviolet light is used to excite unlabeled DNA and RNA in cell nuclei to produce photoacoustic waves. | 2014-12-04 |
20140356898 | DEVICES AND METHODS FOR OVERLAYING BLOOD OR CELLULAR SUSPENSIONS - A device is described that overlays a first fluid, such as blood or a cellular suspension onto a base material, such as a density gradient. In some embodiments, the fluid layering device includes a cylindrical reservoir, a fluid barrier, a coupling extension, a plunger, and an exhaust vent. The fluid layering device can be coupled through its coupling extension to an open end of a container, such as a conical centrifuge tube, including the density gradient. Once attached, the plunger may be lowered to a position above the surface of the density gradient. A first fluid may flow from the reservoir into the conical tube across the plunger, so that a suitable overlay is formed without substantially disturbing a surface of the density gradient. The plunger may be buoyed upward by the first fluid during operation, providing a constant regulation of flow throughout overlaying, regardless of the care and skill of the user. | 2014-12-04 |
20140356899 | Biological Contamination Modeling of Surfaces in Hot Humid Air - A protocol process is provided for testing and evaluating | 2014-12-04 |
20140356901 | Method and Device for Detecting Device Colonization - Technologies are generally described for a method and a device for detecting device colonization. Disclosed herein is an indwelling medical device configured to detect a biofilm. The device comprises a substrate configured to contact blood and a detecting material, disposed with the substrate, configured to detect the presence of a biofilm thereon. The detecting material is soluble in blood, removable by kidneys from the blood, and passable to urine by the kidneys for detection in the urine. A method for detecting the growth of a biofilm on an indwelling medical and a method for making an indwelling medical device are also disclosed herein. | 2014-12-04 |
20140356902 | Method for Discovering Algal Strains with Reduced Pigment to Attain Higher Photosynthetic Efficiency - A method for determining and/or engineering photosynthetic mutant algal strains comprising: (A) pre-screening wild-type or parent strains to select for photosynthetic efficiency; (B) cause genetic mutations in the group of wild-type and/or parent strains from pre-screening (A) to form genetic mutant strains; (C) screening the genetic mutant strains for photosynthetic efficiency in mass cultures; and (D) further screening the genetic mutants resulting from screening (C) by measuring biomass productivity to select strains having relatively high biomass/lipid/starch productivity. | 2014-12-04 |
20140356903 | HEMATOLOGICAL ANALYZER, METHOD FOR ANALYZING BODY FLUID AND COMPUTER PROGRAM PRODUCT - A hematological analyzer for measuring blood, sets a body fluid measurement mode; receives a measurement start instruction; irradiates a measurement sample with light and obtains optical information from cells contained in the measurement sample; and classifies at least white blood cells and nucleated cells other than white blood cells contained in the measurement sample, and counts the white blood cells and nucleated cells other than white blood cells based on the optical information obtained from the cells in the measurement sample prepared from a body fluid sample and white blood cell measuring reagent when the body fluid measurement mode has been set and the measurement start instruction has been selected, is disclosed. A method for analyzing body fluid and a computer program product are also disclosed. | 2014-12-04 |
20140356904 | BACULOVIRUS EXPRESSION SYSTEMS - The present invention relates to an optimized baculovirus construct useful for the production of virus (-like) particles or viral vectors, in particular viral vectors for gene therapy. | 2014-12-04 |
20140356905 | Mammalian Cell Culture System for Large-Scale Expression of Recombinant Proteins - Compositions and methods for large-scale recombinant protein expression are disclosed. | 2014-12-04 |
20140356906 | METHODS AND PRODUCTS FOR TRANSFECTING CELLS - The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed. | 2014-12-04 |
20140356907 | ANTIBODY PRODUCTION - A transgenic non-human mammal containing a heterologous lambda light chain gene locus, and/or a heterologous kappa light chain gene locus, and/or a heterologous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge. | 2014-12-04 |
20140356908 | BINDING MOLECULES - A transgenic non-human mammal containing a heterologous heavy chain gene locus that is capable of producing soluble heavy chain only antibodies and antigen-binding fragments thereof following immunization. | 2014-12-04 |
20140356909 | IL-17 BINDING PROTEINS - Proteins that bind IL-17 and/or IL-17F are described along with their use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions. | 2014-12-04 |
20140356910 | METHODS FOR INCREASING MANNOSE CONTENT OF RECOMBINANT PROTEINS - The present invention relates to methods of upregulating the high mannose glycoform content of a recombinant protein during a mammalian cell culture by manipulating the mannose to total hexose ratio in the cell culture media formulation. | 2014-12-04 |
20140356911 | Method for Producing Protein - The present invention relates to a recombinant host cell, wherein the cell is modified to increase the expression levels of Ero1 and XBP1 relative to the expression levels of Ero1 and XBP1 in an unmodified cell. The present invention also relates to a method of producing a recombinant protein of interest comprising expressing the recombinant protein of interest in the recombinant host cell. | 2014-12-04 |
20140356912 | CELL-BASED PRODUCTION OF NONULOSONATES - The present invention relates to the the cell-based production of bacterial nonulosonates and their biosynthetic precursors. Specifically, the present invention provides recombinant cells for the production of pseudaminic acid, legionaminic acid, UDP-2,4-diacetamido-2,4,6-trideoxy-□-L-altropyranose, and UDP-2,4-diacetamido-2,4,6-trideoxy-□-D-glucopyranose. Methods for producing the sugars are also provided. | 2014-12-04 |
20140356913 | Enzymes Manufactured in Transgenic Soybean for Plant Biomass Engineering and Organopollutant Bioremediation - A strategy for eliminating or greatly reducing the need for physical/chemical treatments or the use of whole microbes for lignocellulosic biomass and organopollutant degradation is disclosed. The soybean is a practical, cost-efficient and sustainable bioreactor for the production of lignin-degrading and cellulose-degrading enzymes. The use of soybean as a transgenic overexpression platform provides advantages that no other industrial scale enzyme expression system can match. Availability of a battery of related plant biomass degrading enzymes in separate transgenic soybean lines provides unprecedented flexibility in industrial and bioremediation processes. Depending upon the particular application, selected soybean-derived powdered enzyme formulations can be used, and their sequential addition can be orchestrated. Manufacturing enzymes using transgenic soybeans wherein these enzymes are capable of lignocellulose and organopollutant degradation into useful or nontoxic products will dramatically change biomass engineering schemes and environmental remediation practices. This technology has a sum of advantages that other protein expression system cannot duplicate, including the manufacturing of individual enzymes in a cost-effective manner that allows flexibility in cocktail composition, ease of application, and long term storage in the absence of a cold chain. | 2014-12-04 |
20140356914 | ENDOGLUCANASE 1B - The present invention provides endoglucanase 1b (EG1b) suitable for use in saccharification reactions. | 2014-12-04 |
20140356915 | INTEGRATED BIOREFINERIES FOR PRODUCTION OF SUGARS, FERMENTATION PRODUCTS, AND COPRODUCTS - Processes are described for fractionating lignocellulosic biomass into cellulose, hemicellulose, and lignin, comprising fractionating lignocellulosic biomass in the presence of a solvent for lignin (such as ethanol), a hydrolysis catalyst (such as sulfur dioxide), and water, to produce a liquor containing hemicellulose, cellulose-rich solids, and lignin; hydrolyzing the hemicellulose to produce hemicellulosic monomers; saccharifying the cellulose-rich solids to produce glucose; recovering the hemicellulosic monomers and the glucose, separately or in a combined stream, as fermentable sugars; and fermenting the fermentable sugars to a fermentation product having a higher normal boiling point than water. Process integration of mass and/or energy is disclosed in many specific embodiments. The fermentation product may include an organic acid, an alcohol, a diol, or combinations thereof. | 2014-12-04 |
20140356916 | PROCESSES AND RECOMBINANT MICROORGANISMS FOR THE PRODUCTION OF FINE CHEMICALS - Recombinant microorganisms with deregulated succinyl-CoA synthetase activity, as well as the uses for producing lysine, β-lysine, cadaverine or N-acetylcadaverine thereby are provided. Recombinant polypeptides comprising an amino acid sequence being at least 80% identical to SEQ ID NO: 51 or 53 are also provided. The method of producing fine chemicals using said recombinant microorganisms, in particular the method of producing lysine, or derivatives thereof, such as β-lysine, cadaverine or N-acetylcadaverine is further provided. | 2014-12-04 |
20140356917 | PROCESS FOR PRODUCING LIPIDS SUITABLE FOR BIOFUELS - The present invention provides a cost effective biotechnological process for production of bio-fuels from isolated and characterized microalgae. The algal strains used in the present invention having higher biomass, higher lipid productivity, higher pH and temperature tolerance are selected from the group consisting of | 2014-12-04 |
20140356918 | PROCESS FOR SYNTHESIZING BIFUNCTIONAL HYDROCARBON-BASED COMPOUNDS FROM BIOMASS - The subject of the present invention is a process for synthesizing bifunctional hydrocarbon-based compounds from biomass, comprising a step of fermentation of the biomass and a step of oxidation of the intermediate compounds resulting from the fermentation step. | 2014-12-04 |
20140356919 | ORGANISMS FOR THE PRODUCTION OF CYCLOHEXANONE - A non-naturally occurring microbial organism has cyclohexanone pathways that include at least one exogenous nucleic acid encoding a cyclohexanone pathway enzyme. A pathway includes a 2-ketocyclohexane-1-carboxyl-CoA hydrolase (acting on C—C bond), a 2-ketocyclohexane-1-carboxylate decarboxylase and an enzyme selected from a 2-ketocyclohexane-1-carboxyl-CoA hydrolase (acting on thioester), a 2-ketocyclohexane-1-carboxyl-CoA transferase, and a 2-ketocyclohexane-1-carboxyl-CoA synthetase. A pathway includes an enzyme selected from a 6-ketocyclohex-1-ene-1-carboxyl-CoA hydrolase (acting on C—C bond), a 6-ketocyclohex-1-ene-1-carboxyl-CoA synthetase, a 6-ketocyclohex-1-ene-1-carboxyl-CoA hydrolase (acting on thioester), a 6-ketocyclohex-1-ene-1-carboxyl-CoA transferase, a 6-ketocyclohex-1-ene-1-carboxyl-CoA reductase, a 6-ketocyclohex-1-ene-1-carboxylate decarboxylase, a 6-ketocyclohex-1-ene-1-carboxylate reductase, a 2-ketocyclohexane-1-carboxyl-CoA synthetase, a 2-ketocyclohexane-1-carboxyl-CoA transferase, a 2-ketocyclohexane-1-carboxyl-CoA hydrolase (acting on thioester), a 2-ketocyclohexane-1-carboxylate decarboxylase, and a cyclohexanone dehydrogenase. A pathway includes an adipate semialdehyde dehydratase, a cyclohexane-1,2-diol dehydrogenase, and a cyclohexane-1,2-diol dehydratase. A pathway includes a 3-oxopimelate decarboxylase, a 4-acetylbutyrate dehydratase, a 3-hydroxycyclohexanone dehydrogenase, a 2-cyclohexenone hydratase, a cyclohexanone dehydrogenase and an enzyme selected from a 3-oxopimeloyl-CoA synthetase, a 3-oxopimeloyl-CoA hydrolase (acting on thioester), and a 3-oxopimeloyl-coA transferase. Each these pathways can include a PEP carboxykinase. A method for producing cyclohexanone includes culturing these non-naturally occurring microbial organisms. | 2014-12-04 |
20140356920 | RECOVERY OF HIGHER ALCOHOLS FROM DILUTE AQUEOUS SOLUTIONS - This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allow recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs. | 2014-12-04 |
20140356921 | Engineering Microorganisms to Increase Ethanol Production by Metabolic Redirection - The present invention provides for the manipulation of carbon flux in a recombinant host cell to increase the formation of desirable products. The invention relates to cellulose-digesting organisms that have been genetically modified to allow the production of ethanol at a high yield by redirecting carbon flux at key steps of central metabolism. | 2014-12-04 |
20140356922 | POLYPEPTIDES HAVING GLUCOAMYLASE ACTIVITY AND METHOD OF PRODUCING THE SAME - The present invention relates to polypeptides having glucoamylase activity with improved properties and to compositions comprising these polypeptides suitable for use in the production of a food, beverage (e.g. beer), feed, or biofuel. Also described is an improved and cost-effective process for isolating glucoamylases suitable for large scale protein purification procedures. Furthermore, different methods and uses related to glucoamylases according to the invention are disclosed, such as in a brewing process. | 2014-12-04 |
20140356923 | BACTERIA WITH RECONSTRUCTED TRANSCRIPTIONAL UNITS AND THE USES THEREOF - The present invention relates to recombinant bacteria and the uses thereof, particularly for the production of ethanol. The invention also relates to methods for the production of such bacteria, as well as to nucleic acid constructs suitable for such production. The invention specifically relates to bacteria having a reconstructed biomass degradation unit. | 2014-12-04 |
20140356924 | Alpha-amylase variant with altered properties - The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered properties relative to the parent alpha-amylase. | 2014-12-04 |
20140356925 | POLYPEPTIDE CAPABLE OF ENHANCING CELLULOSIC BIOMASS DEGRADATION - The saccharification efficiency of cellulase is enhanced within reaction temperature regions of general fermenting microorganisms other than heat-resistant yeast. Cellulosic biomass is saccharified with cellulase in the presence of a polypeptide comprising the amino acid sequence shown in SEQ ID NO: 2 or 4 and having a function of enhancing the saccharifying activity of cellulase. | 2014-12-04 |
20140356926 | Novel sesquiterpene synthase gene and protein - The invention relates to sesquiterpene synthases and methods for their production and use. Particularly, the invention provides nucleic acids comprising the nucleotide sequence of citrus valencene synthase (CVS) which codes for at least one CVS. The invention further provides nucleic acids comprising the nucleotide sequence coding for amino acid residues forming the tier 1 and tier 2 domains of CVS. The invention also provides for methods of making and using the nucleic acids and amino acids of the current invention. | 2014-12-04 |