49th week of 2015 patent applcation highlights part 41 |
Patent application number | Title | Published |
20150346114 | SYSTEM AND METHOD FOR INSPECTING A BODY - A system for inspecting a body, which includes a first end side, a second end side, and cells extending through the body from the first end side to the second end side, is provided. The system includes at least one light source configured to project light through and out of at least one corresponding group of the cells, a target configured to display the light projected through and out of the at least one corresponding group of the cells, an imaging system configured to determine at least one location of the displayed light on the target, and a system processor configured to compare the determined at least one location of the displayed light with a location of the at least one light source and calculate, from the comparison thereof, at least one of a pointing angle and a pointing vector for the at least one corresponding group of the cells. | 2015-12-03 |
20150346115 | 3D OPTICAL METROLOGY OF INTERNAL SURFACES - Embodiments regard 3D optical metrology of internal surfaces. Embodiments may include a system having an imaging device to capture multiple images of an internal surface, including a first image that is captured at a first location on an axial path and a second image that is captured at a second location on the axial path, and a transport apparatus to move the imaging device along the axial path. The system further includes a control system that is coupled with the imaging, wherein the control system is to receive the multiple images from the imaging device and to generate a 3D representation of the surface based at least in part on content information and location information for the multiple images. | 2015-12-03 |
20150346116 | Metrology Method and Apparatus, Lithographic System and Device Manufacturing Method - A lithographic process is used to form a plurality of target structures (T) on a substrate (W). Each target structure comprises overlaid gratings each having a specific overlay bias. Asymmetry (A) of each grating, measured by scatterometry, includes contributions due to (i) the overlay bias, (ii) an overlay error (OV) in the lithographic process and (iii) bottom grating asymmetry within the overlaid gratings. Asymmetry measurements are obtained for three or more target structures having three or more different values of overlay bias (e.g., −d, | 2015-12-03 |
20150346117 | CONDUCTIVITY MEASUREMENTS - The present invention relates to a system for measuring conductivity in a multiphase fluid flow comprising a fraction of water, the system comprising a measuring section including means for emitting electromagnetic signals into a pipe containing said flow within at least one chosen frequency range and means for detecting resonant frequencies within said range. The measuring section comprising features for providing at least two resonanct frequencies within said at least one frequency range, the system also comprising means for based on at least a first resonant frequency and a first Q-factor related to the corresponding resonance peak as well as the Q-factor of a second resonance peak, calculating the conductivity of the water in said flow. | 2015-12-03 |
20150346118 | Multi-Linear X-Ray Scanning Systems and Methods for X-Ray Scanning - A scanning transmission x-ray imaging system includes an x-ray source producing x-rays at a focal spot and moving about a source movement axis passing through the focal spot, x-ray detector arrays each detecting x-rays from the x-ray source along a detector dimension, and a collimator between the source and the arrays, fixed to the source, and defining slits to collimate the x-rays into a set of linear x-ray beams. The arrays are spaced from the source such that the linear x-ray beam at each of the arrays has the linear x-ray beam substantially impact within a height and width of a respective one of the arrays. The arrays move correspondingly with the source such that each of the linear x-ray beams remain aligned with a respective one of the arrays. | 2015-12-03 |
20150346119 | Determining Perforation Tunnel Impairment Productivity Using Computed Tomography - Disclosed is a method of testing the effectiveness of perforations and well treatments to enhance production, wherein tomographic image data is collected while fluid flow tests are conducted on a formation sample and thereafter three dimensional images are created and analyzed. | 2015-12-03 |
20150346120 | SCANNING ILLUMINATING DEVICE, IMAGING DEVICE COMPRISING SAME AND METHOD OF IMPLEMENTATION - A scanning illuminating device includes an emission centre from which radiation is emitted in an illuminating sector. A cylindrical ring is centred on the source and is rotatably movable about a first axis. The ring includes a plurality of slits regularly distributed about its axis of rotation and having the same angular amplitude α. A cylinder portion is centred on the source and is rotatably movable about a second axis crossing the first axis at the centre and forming a nonzero angle therewith. The cylinder portion includes a slit having an angular amplitude β. A first device control of the rotation of the ring, defining an elementary angular step αα such that an integer N1 other than 1 meets the condition α=N1.αα. A second device controls the rotation of the ring portion defining an angular step ββ such that an integer N2 other than 1 meets the condition β=N2.ββ. | 2015-12-03 |
20150346121 | INTEGRATED RECIPROCAL SPACE MAPPING FOR SIMULTANEOUS LATTICE PARAMETER REFINEMENT USING A TWO-DIMENSIONAL X-RAY DETECTOR - A method for performing an X-ray diffraction analysis of a crystal sample using a multi-dimensional detector that integrates an X-ray diffraction signal while the position of the sample relative to an X-ray source is changed along a scan direction. The resulting image is compressed along the scan direction, but may be collected very quickly. The capture of both on-axis and off-axis reflections in a single image provides a common spatial frame of reference for comparing the reflections. This may be used in the construction of a reciprocal space map, and is useful for analyzing a sample with multiple crystal layers, such as a crystal substrate with a crystalline film deposited thereupon. | 2015-12-03 |
20150346122 | APPARATUS AND METHOD FOR DETECTING WATER OR ICE - The present invention relates to an apparatus and method for detecting the presence of water or ice on a structure, for example on the surface of an aircraft. One or more separate heaters are thermally coupled to a structure (for example on the back of wing leading edge skins). A controller applies power to the heaters to heat the different regions of the surface of the structure. The controller detects the presence of water or ice by comparing the power required to achieve the desired surface temperature, and a reference power, where the reference power is the power required to heat the surface of the structure to the same temperature if the structure were in a dry air environment (i.e. an environment devoid of water). If the power consumed by the heater is greater than the reference power, the presence of water or ice is inferred. | 2015-12-03 |
20150346123 | Method for detecting the degree of soiling of PV modules - A method for detecting the degree of soiling of PV modules of a string comprises the following steps: determination of the deviations of the string power output values from a calculated reference value over the last year; calculation of a historical trend line from the deviations; determination of a maximum difference between the trend line and the deviations; calculation of final deviations of the power output values through subtraction of the maximum difference from the trend line; and determination of the degree of soiling through subtraction of the final deviations from the deviations. | 2015-12-03 |
20150346124 | Method and Apparatus for Determining the Salinity of a Sample - An apparatus for determining the salinity of an ionic sample consisting essentially of: a single current probe having a central aperture large enough to accommodate a tube that contains the ionic sample; a network analyzer electrically coupled to the current probe, wherein the network analyzer is configured to transmit power into the ionic sample when the tube containing the ionic sample is positioned within the central aperture and then further configured to measure the return loss parameter of a signal voltage waveform reflected from the ionic solution; and a reference table of reference sample properties to which the measured return loss parameter may be compared to determine the level of salinity of the ionic sample. | 2015-12-03 |
20150346125 | ELECTRICAL CHARACTERISTIC MEASURING DEVICE - There is provided an electrical characteristic measuring device including a rotating mechanism that rotates a sample container to be filled with blood to be measured, to any angle, and a measurement unit that applies a voltage between a pair of electrodes installed in the sample container, and chronologically measures electrical characteristics of the blood. | 2015-12-03 |
20150346126 | SENSOR, MEASURING DEVICE, AND MEASURING METHOD - A sensor measures a sample in a measuring cell including a helix conductor. The shell structure of the measuring cell is made of an electrically non-conductive material. The measuring cell and at least part of the helix conductor are placeable inside a chamber. A radio-frequency signal input element couples a radio-frequency signal to the chamber to form a helix resonance. A radio-frequency signal output element is responsive to a helix resonance of the helix conductor and transmits a radio-frequency signal for measurement. A device for measuring a sample in a measuring cell includes the sensor, a radio-frequency signal source, and a measuring and control part. The radio-frequency signal source produces a radio-frequency signal to the input element. The measuring and control part measures a property of a sample on the basis of a resonance frequency. | 2015-12-03 |
20150346127 | MOISTURE INGRESS SENSORS - This application relates to a moisture ingress sensor. In particular, this application relates to a moisture ingress sensor that can detect liquid ingress into an electronic device. The moisture ingress sensor can include a resistor, an N-channel MOSFET, an operation amplifier, comparators, and an AND logic gate. The moisture ingress sensor is configured to provide a lower power means for accurately detecting moisture in an electronic device. Multiple areas of the electronic device can include the moisture ingress sensor in order to optimize the detection of moisture for at a variety of regions of the electronic device. Additionally, the electronic device can record signals from the moisture ingress sensor and shut down components of the electronic device that could be affected by the detected moisture. Furthermore, the moisture ingress sensor can be tuned to detect one or more types of liquids. | 2015-12-03 |
20150346128 | Salt-based method to monitor and log the times a data center air goes above a predefined limit - A salt-based method to monitor and log the time periods a data center air's relative humidity goes above a predefined limit. The choice of the salt is such that its deliquescent relative humidity is equal to the desired limit, so that above the desired limit, the salt gets wet and therefore electrically conductive. An alarm can then give notice that relative humidity levels are above acceptable levels so that remedial action may be taken before problems such as electronic malfunction develop. | 2015-12-03 |
20150346129 | TOMOGRAPHIC DETERMINATION OF MULTIPHASE FLOWS IN PIPES AND/OR LIQUID/FROTH INTERFACES IN PROCESS TANKS USING HIGH SPEED MULTIPLEXED ELECTRICAL IMPEDANCE SENSING - Apparatus is provided featuring a signal processor or processing module configured at least to: receive signaling containing information about coded and multiplexed voltages measured across pairs of electrodes in an array of electrodes configured in relation to a fluid processing structure, including a pipe, tank, vessel, vat or container, having a process fluid therein; and determine using a tomographic signal processing algorithm a tomographic indication of the process fluid, based at least partly on the signaling received. The signal processor module may be configured to provide corresponding signaling containing information about the tomographic indication of the process fluid. The tomographic indication includes a 2D or 3D image or visualization of the process fluid, including an analysis of mixing in multiphase flows, liquid interfaces or liquid-froth layers detected in the process fluid. | 2015-12-03 |
20150346130 | Conductive Fabric Seal - Disclosed are several examples of a system and method for detecting if an article is being tampered with. Included is a covering made of a substrate that is coated with a layer of an electrically conductive material that forms an electrically conductive surface having an electrical resistance. The covering is configured to at least partially encapsulate the article such that the article cannot be tampered with, without modifying the electrical resistance of the electrically conductive surface of the covering. A sensing device is affixed to the electrically conductive surface of the covering and the sensing device monitors the condition of the covering by producing a signal that is indicative of the electrical resistance of the electrically conductive surface of the covering. A measured electrical resistance that differs from a nominal electrical resistance is indicative of a covering that is being tampered with and an alert is communicated to an observer. | 2015-12-03 |
20150346131 | SENSOR APPARATUS, SYSTEMS AND METHODS OF MAKING SAME - A sensor system can be configured to perform dielectric spectroscopy (DS). For example, the system can include a sensor configured to measure dielectric permittivity of a fluid in response to an RF input signal. Associated interface electronics can include a transmitter to drive the sensor with the RF input signal and a receiver to receive and process an RF output signal from the sensor in response to the RF input signal. | 2015-12-03 |
20150346132 | APPARATUS FOR IDENTIFYING A VALUE OF A PROPERTY OF A FLUID WHICH IS TO BE MEASURED, METHOD FOR OPERATING AN APPARATUS FOR IDENTIFYING A VALUE OF A PROPERTY OF A FLUID WHICH IS TO BE MEASURED, AND METHOD FOR MANUFACTURING AN APPARATUS FOR IDENTIFYING A VALUE OF A PROPERTY OF A FLUID WHICH IS TO BE MEASURED - An apparatus is provided for identifying a property value of a fluid which is to be measured, a method for operating such an apparatus, and a method for manufacturing such an apparatus. The apparatus encompasses: | 2015-12-03 |
20150346133 | APPARATUS AND METHOD OF DISCRIMINATING REFORMULATED FUEL - Provided is an apparatus of discriminating reformulated fuel, which includes a fuel sensing unit including first and second electrode plates which are spaced and face each other, and a measuring part connected to the first and second electrode plates; a fuel control valve unit including a control valve part blocking the fuel passage and a second actuator driving the control valve part; and a control unit connected to the measuring part and the second actuator, and operating the second actuator based on a capacitance measured from the measuring part. | 2015-12-03 |
20150346134 | DITHIENYLPYRROLE-BASED BIOSENSORS AND METHODS FOR THEIR PREPARATION AND USE - Dithienylpyrrole compounds, compositions containing dithienylpyrrole polymers, and methods for making the compounds and compositions are disclosed herein. The compositions containing dithienylpyrrole polymers, can for example, be used as conducting polymers in biosensors for detecting analytes in a sample. | 2015-12-03 |
20150346135 | Electrochemical Gas Sensor - A gas detector includes an electrochemical gas sensor. The sensor includes a plurality of electrodes. At least one of the electrodes is formed of a catalyst/binder slurry which is halftone printed onto a substrate. The composite printed element and substrate are sintered to form the electrode. | 2015-12-03 |
20150346136 | LIQUID SENSOR - A sensor may be provided with a first electrode having a first opposing surface; a second electrode having a second opposing surface opposing the first opposing surface with an interval in between; an insulator accommodating the first electrode and the second electrode, and contacting a contact surface being a part of a surface of the first electrode other than the first opposing surface, or a part of a surface of the second electrode other than the second opposing surface, or a combination thereof; and a shield electrode surrounding the insulator. The shield electrode may have a third opposing surface opposing the contact surface via the insulator. The third opposing surface may contact the insulator. | 2015-12-03 |
20150346137 | LIQUID SENSOR - A liquid sensor may be provided with a lid disposed at an opening of the container, and having an insertion hole; a control circuit; a case housing the control circuit, and being assembled with the lid; a first electrode integrally fixed to the case, and protruding from the case so as to be positioned on a container side of the insertion hole; a second electrode integrally fixed to the lid, and opposing the first electrode with an interval in between; and a terminal extending from the control circuit and piercing the case, and electrically in contact with the second electrode. | 2015-12-03 |
20150346138 | PHOTOPATTERNABLE GLASS MICRO ELECTROCHEMICAL CELL AND METHOD - A micro electrochemical cell, a micro electrochemical gas sensor, and a method for fabrication of the micro electrochemical cell are described that include a photopatternable glass substrate, two or more embedded electrodes integrated with through-glass vias, and a gas-permeable membrane lid. In an implementation, a micro electrochemical cell includes a photopatternable glass substrate; at least one recess formed in the photopatternable glass substrate; a plurality of through-glass vias formed in the photopatternable glass substrate, at least one electrolyte disposed in the at least one recess; a wicking layer disposed over the at least one electrolyte; and a lid assembly. | 2015-12-03 |
20150346139 | PERACETIC ACID CONCENTRATION METER - A main object of the present invention is to provide a membrane covered type peracetic acid concentration meter that can prevent various common problems, including problems that occur in the event of an internal solution leak into a sample solution. The membrane covered type peracetic acid concentration meter adapted to measure the concentration of peracetic acid in the sample solution includes: a membrane that allows peracetic acid to permeate; and the internal solution that dissolves peracetic acid having permeated the membrane. In addition, as the internal solution, a buffer solution having a buffering action on hydrogen ion concentration is used. | 2015-12-03 |
20150346140 | HYDROGEN QUALITY MONITOR - A pair of fuel cells are configured as a hydrogen purity monitor. A first cell, acting as a reference cell, is configured to generate electrical current from the electrochemical reaction of hydrogen and oxidant and has a first fuel inlet configured to receive hydrogen from a first hydrogen source. A second fuel cell, acting as a test cell, is configured to generate electrical current from the electrochemical reaction of hydrogen and oxidant and has a second fuel inlet configured to receive hydrogen from a second hydrogen source. A control system is configured to apply an electrical load to each fuel cell and determine an electrical output of each fuel cell. The control system has a comparator for comparing the electrical outputs of the first and second fuel cells and a purity monitor output configured to give an indication of hydrogen purity based on an output of the comparator. | 2015-12-03 |
20150346141 | DNA-Decorated Graphene Chemical Sensors - The present invention provides a broad response single-stranded DNA-graphene chemical sensor device. The present invention also provides methods for improving the ability of graphene to work as a chemical sensor by using single-stranded DNA as a sensitizing agent. | 2015-12-03 |
20150346142 | DETERMINATION OF THE REAL ELECTROCHEMICAL SURFACE AREAS OF SCREEN PRINTED ELECTRODES - A method is provided for determining a real electrochemical surface area of a working electrode (WE) of a screen printed sensor. A concentration of a mediator incorporated in a WE paste is determined. The diffusion coefficient of the mediator is then ascertained. A final real electrochemical surface area of the WE is then made. | 2015-12-03 |
20150346143 | A MULTI-FUNCTIONAL SENSOR FOR AN ELECTROCHEMICAL DETECTION SYSTEM - Provided herein is a system, including a platform for performing at least one assay protocol. The platform may include a flow cell that can include at least one sensor. The platform may also include a reader that can be in communication with the sensor. Moreover, the sensor may maintain communication with the reader for the entirety of the performance of the assay protocols to transmit data regarding physical events within the flow cell or an electrochemical state of any substance contained within the flow cell. | 2015-12-03 |
20150346144 | PH METER - Voltammetric sensors prepared from composite materials and optionally using microfabrication techniques enable detection of analyte in sample volumes under ten microliters. | 2015-12-03 |
20150346145 | DEVICE FOR PERFORMING ELECTROPHORESIS PRODUCING MIRROR COPIES OF SEPARATED PROTEINS BY USING THE SAME GEL AND THE SAME SAMPLES - A gel matrix device for performing polyacrylamide gel electrophoresis, comprising: a back plate having spacers on both vertical sides thereof; a front plate, shorter than the back plate; and a middle plate having a middle part shorter than the front plate, two side parts having the same height as the back plate and spacers on both vertical sides thereof, the spacers having the same height as the back plate spacers, wherein said middle plate divides the volume between said back and front plates into two compartments and wherein each one of said two compartments comprises gel up to the height of said middle plate, and wherein the gel continues above the middle plate in an area common to the two compartments, said area comprising wells for sample loading. | 2015-12-03 |
20150346146 | ELECTROPHORESIS METHOD AND ELECTROPHORESIS DEVICE - To provide an electrophoresis method and an electrophoresis device which can reduce difficulty in operation while implementing sufficient staining. An electrophoresis device includes a temperature gradient tank, a dispenser, a holder storage cabinet, a photographing unit, a PCR device, a chip rack, a chip disposal box, a DC power unit, a control unit, an arm, and a liquid feeder. A holder and a cassette removably attached to the holder are put on the temperature gradient tank. The control unit controls a carrying device, the arm, the liquid feeder, the temperature gradient tank, an excitation light source and a camera in the photographing unit, and the DC power unit. The control unit prestores a program for executing the control operation in its internal memory. | 2015-12-03 |
20150346147 | PIPETTES, METHODS OF USE, AND METHODS OF STIMULATING AN OBJECT OF INTEREST - One embodiment of the invention provides a system adapted and configured to generate a localized flow circulation zone. The system includes: a free-standing microfluidic pipette comprising three or more channels with exits separated from each other by an outer surface of the pipette; and a controller programmed to control fluid flows through each of the three or more channels to generate a localized recirculating fluid flow path outside the pipette. Liquid leaving the microfluidic pipette through at least one outlet channel exit is withdrawn through at least two inlet channel exits. | 2015-12-03 |
20150346148 | Method and Apparatus for Manipulating Samples Using Optoelectronic Forces - An apparatus for controlling the motion of a particle and a method for using the same are disclosed. The apparatus includes a channel containing liquid between first and second electrodes. The apparatus also includes an array of variable impedance elements, each variable impedance element connecting the first electrode to a corresponding location in the channel by a path having an average impedance that is continuously variable between first and second impedances when averaged over an update time interval. A controller sets the average impedance of each of the variable impedance elements such that a particle in the channel moves in a predetermined direction when voltage is applied between the first and second electrodes. At least one of the variable impedance elements has an average impedance that is intermediate between the first and second impedances. | 2015-12-03 |
20150346149 | BIOCHEMICAL ANALYSIS INSTRUMENT - An analysis instrument comprises plural modules connected together over a data network, each module comprising an analysis apparatus operable to perform biochemical analysis of a sample. Each module comprises a control unit that controls the operation of the analysis apparatus. The control units are addressable to select an arbitrary number of modules to operate as a cluster for performing a common biochemical analysis. The control units communicate over the data network, repeatedly during the performance of the common biochemical analysis, to determine the operation of the analysis apparatus of each module required to meet the global performance targets, on the basis of measures of performance derived from the output data produced by the modules. The arrangement of the instrument as modules interacting in this manner provides a scalable analysis instrument. | 2015-12-03 |
20150346150 | AUTOSOMAL-DOMINANT POLYCYSTIC KIDNEY DISEASE (ADPKD) - The process for the diagnosis, early detection and prognosis of the clinical development of autosomal-dominant polycystic kidney disease (ADPKD) comprises the step of determining the presence or absence or amplitude of at least three polypeptide markers in a urine sample, the polypeptide markers being selected from the markers characterized in Table 1 by values for the molecular masses and migration times. | 2015-12-03 |
20150346151 | CAPILLARY ELECTROPHORESIS SYSTEM - The invention is an improved multiplex capillary electrophoresis instrument or module with at least four and preferably six user-accessible vertically stacked drawers. An x-z stage moves samples from the user accessible drawers to the capillary array for analysis. A computer program allows users to add capillary electrophoresis jobs to a queue corresponding to the analysis of rows or plates of samples without stopping or interrupting runs in progress. | 2015-12-03 |
20150346152 | MASS SPECTROMETRY SYSTEMS AND METHODS FOR ANALYSES ON LIPID AND OTHER IONS USING A UNIQUE WORKFLOW - The applicants' teachings provide in some aspects methods and apparatus for mass spectrometric analysis that identify the location of carbon-carbon double bonds, if any, in an analyte by (1) obtaining the m/z ratio of the intact analyte ions, (2) subjecting these ions to collision-induced dissociation and (3) determining relationships between masses and/or mass-to-charge ratios of the intact analyte ions and the fragments produced by such collision-induced dissociation. The methods and apparatus selectively subject analyte ions to ozone-induced dissociation based on those relationships and determine location(s) of carbon-carbon double bonds, if any, from reaction products of ozone-induced dissociation. | 2015-12-03 |
20150346153 | METHODS AND SYSTEMS FOR DETECTING NONUNIFORMITIES IN A MATERIAL, COMPONENT, OR STRUCTURE - Methods of detecting non-uniformities in a material are described. Such methods can comprise inducing changes in strain state or changing the magnetic moment of a material and measuring magnetic flux leakage that is synchronous with the changes in strain state or magnetic moment, while simultaneously applying an external magnetic field to control the relative magnitude of the magnetic flux leakage. | 2015-12-03 |
20150346154 | INNER DETECTING DEVICE FOR SUBSEA OIL AND GAS PIPELINE - An inner detecting device for subsea oil and gas pipeline includes a support shaft defining a sealed chamber therein; a packer cup coupled to the support shaft; a hinge assembly coupled to the support shaft, swinging with respect to the support shaft in a radial direction and sliding with respect to the support shaft in an axial direction; a magnetic detector connected to the hinge assembly to move with respect to the support shaft in the radial and axial directions, and the magnetic detector tending to move away from the support shaft in the radial direction; a battery pack; an electric recorder electrically connected to the battery pack; and a mileage recorder recording a travel distance of the inner detecting device within the pipeline. | 2015-12-03 |
20150346155 | DEVICE FOR THE NONDESTRUCTIVE TEST OF A PART - Eddy current testing to detect defects at the surface or at shallow depth in a part, in particular a blade root for an airplane engine fan. The device comprises a probe ( | 2015-12-03 |
20150346156 | METHOD FOR EVALUATING THE CLOGGING OF A HEAT EXCHANGER - The invention relates to a method for evaluating the clogging of the passages of a tube support plate of a tube heat exchanger, in which an eddy current probe is passed through a tube of said exchanger and a measurement signal is measured with said probe, and, to evaluate the clogging at the downstream edge of a tube support plate:
| 2015-12-03 |
20150346157 | METHOD AND DEVICE FOR IMPROVING THE SAFT ANALYSIS WHEN MEASURING IRREGULARITIES - The invention relates to a method and to a corresponding device in which irregularities regarding each detected measurement position within a measurement surface are detected using a local measurement density. Each echo signal received in response to each detected measurement position is then weighted in order to generate an image using a data processing device such that the irregularities are adjusted. | 2015-12-03 |
20150346158 | DEVICE FOR THE AUTOMATED NON-DESTRUCTIVE TESTING OF STIFFENERS OF AN AIRCRAFT COMPOSITE STRUCTURE - A device for testing a stiffener of an aircraft structure made from composite materials. At least one ultrasound sensor is configured to provide measurements relative to a material health state of the stiffener. The device includes a protective enclosure for housing the ultrasound sensor and a mobile gantry configured to move along the stiffener. The protective enclosure with the ultrasound sensor is mounted inside the mobile gantry. A driver is configured to drive the mobile gantry along the stiffener. A clamper is rigidly connected to the protective enclosure and configured to hold the ultrasound sensor pressed against the surface of the stiffener to be controlled. A locator to synchronize each area of the surface of the stiffener with the measurement of the ultrasound sensor. | 2015-12-03 |
20150346159 | SENSOR SYSTEM FOR CORROSION MONITORING - A permanently installed monitoring system for corrosion under insulation (PIMSCUI) and a method for performing the monitoring of said system are provided. The present invention attains the objective of the invention by a fibre optic cable permanently mounted between walls of a pipeline and pipeline insulation surrounding the pipeline and placement of acoustic emitters along the length of the pipeline in mechanical contact with the optical fibre. The acoustic emitters send a pulsed acoustic signal towards the pipeline which is received by the optical fibre, the acoustic signal subsequently travels through the pipeline wall, reflecting from the inner diameter of the pipeline before the reflected pulse is received at the optical fibre. | 2015-12-03 |
20150346160 | RECONFIGURABLE DEVICE FOR CHECKING A COMPOSITE STRUCTURE USING ULTRASOUND - An ultrasound device for checking the quality of a composite material structure during the production cycle. Preferably, the device is incorporated into a production tooling performing the LRI process in which the composite material structure is placed between two molds during the production cycle. A layer of piezoelectric material is deposited on the face of one of the molds, opposite the face which is in contact with the structure. One face of an electrically insulating flexible material film is placed against the outer face of the piezoelectric material layer. The face of the film further includes conductive pads in contact with the piezoelectric material layer. Each pad is energized by electric voltage applied by a conductive strip. Each pad forms an independent ultrasonic transducer with the region of the piezoelectric material layer opposite of its placement. | 2015-12-03 |
20150346161 | SYSTEM AND METHOD OF DIAGNOSING TUBE SENSOR INTEGRITY - A structural health monitoring apparatus is presented. According to an embodiment, the structural health monitoring apparatus comprises: a plurality of transducers configured for coupling to a structure, the structure comprising an outer structure surrounding and coupled to an inner structure, the transducers further configured for coupling to only the outer structure so as to transmit stress waves through the inner structure, and still further configured to receive the transmitted stress waves from the outer structure after they have passed through the inner structure; and an analyzer configured to detect damage within the inner structure according to the received transmitted stress waves from the outer structure. | 2015-12-03 |
20150346162 | DETECTION DEVICE - It is an object to improve the visibility of a display screen on which a detected target is displayed. A detection device | 2015-12-03 |
20150346163 | Fuel Dispensing Environment Component Health Monitoring - Methods and systems for monitoring the health and operational status of components in a fuel dispensing environment. In one aspect, a method includes providing a control system having a memory in which is stored information representative of a first vibration characteristic of a component, providing a sensor in electronic communication with the control system, the sensor operative to sense vibration characteristics of the component, and coupling the sensor with the component. The method also includes sensing a second vibration characteristic of the component using the sensor, transmitting information representative of the second vibration characteristic to the control system, and comparing the information representative of the second vibration characteristic to the information representative of the first vibration characteristic. | 2015-12-03 |
20150346164 | SYSTEM AND METHOD OF DYNAMIC GATING IN NON-DESTRUCTIVE WELD INSPECTION - A phased array ultrasonic inspection system configured for weld inspection includes a data analysis process with automated and optimized gating to take into account the actual distance between a phased array probe and a weld line. The system embodies a weld tracking module and a dynamic gating module. The tracking module produces dynamically corrected overlays of the weld line based on the echo signals, the dynamically corrected overlays having a series of offsets from the corresponding initial overlays. The dynamic gating module purposefully positions a plurality of data analysis gates to filter out noise signals caused by sources unrelated to the weld, and to provide dynamic target gating adjusted by at least part of the offset. | 2015-12-03 |
20150346165 | Liquid Injection Panel For A Field-Mountable Gas Chromatograph - A sample injection system for a field-mountable gas chromatograph is described. The system has a sample injection chamber and a vaporization chamber. An analyzer valve is connected to both the vaporization chamber and the gas chromatograph to provide the liquid sample having a dew point above 60° C. and 15 psig to the gas chromatograph. The system and associated valves can be mounted on a panel that is connected to the gas chromatograph, the source of carrier gas and a calibration cylinder. Also described are the purging, sample collection and sample analysis techniques. | 2015-12-03 |
20150346166 | SAMPLE CONCENTRATION DEVICE - A controller for controlling the operations of an autosampler, a sample push unit, and a make-up unit includes a pump stop timing setting unit for setting a first timing T | 2015-12-03 |
20150346167 | FLOW RATE CONTROL MECHANISM AND GAS CHROMATOGRAPH INCLUDING FLOW RATE CONTROL MECHANISM - One end of carrier gas channel, purge gas channel and split gas channel is connected to sample gasification chamber. The other end of carrier gas channel, purge gas channel, and split gas channel is connected to a flow rate control mechanism in the form of carrier gas flow rate control block, purge gas flow rate control block and split gas flow rate control block respectively. Carrier gas flow rate control block, purge gas flow rate control block and split gas flow rate control block constitute a flow rate control unit. This reduces the possibility of leakage of gas to the outside and admixture of impurities from the outside in the flow rate control mechanism. | 2015-12-03 |
20150346168 | SOLVENT DELIVERY SYSTEM FOR LIQUID CHROMATOGRAPHY THAT MAINTAINS FLUID INTEGRITY AND PRE-FORMS GRADIENTS - A solvent delivery subsystem for a chromatography device performs relatively low pressure, high flow mixing of solvents to form a gradient and subsequent high pressure, low flow delivery of the gradient to the separation column. The mixing of the gradient is independent and does not interfere with the gradient delivery. To form the gradient, the outputs of an aqueous pump and an organic pump are mixed to fill a storage capillary while a downstream point from the storage capillary is vented to atmosphere. After gradient formation, the vent to atmosphere is closed, the solvent delivery system rises to high pressure, and only the aqueous pump runs for gradient delivery. To maintain integrity of the fluid stream, the solvent delivery system uses feed forward compensation and controls at least one parameter selected from the group consisting of pressure and flow in the conduit means to follow a gradual ramp. | 2015-12-03 |
20150346169 | METHOD OF AND DEVICE FOR PACKING A CHROMATOGRAPHY COLUMN - A method and device for packing a chromatography column formed of one or more vibration devices attached to top and/or bottom flanges of the column. Media is added in one or more steps to the column, allowed to settle under the effects of gravity and then subjected to one or more treatments of vibration from the vibration devices until a suitably packed column is obtained. Liquid used to suspend the media while being placed into the column may be at least partially removed before or during the vibration step(s). The remaining liquid is then removed or replaced after the packing has been obtained. | 2015-12-03 |
20150346170 | Extraction, Derivatization, and Quantification of Analytes - The present specification discloses methods for determining the presence one or more analytes in a test sample, materials useful to perform the disclosed methods, and kits comprising reagents useful to practice the disclosed methods. | 2015-12-03 |
20150346171 | DATA PROCESSING DEVICE FOR COMPREHENSIVE TWO-DIMENSIONAL CHROMATOGRAPH - In a GC×GC data processor ( | 2015-12-03 |
20150346172 | APPARATUS WITH TIMED COLOR CHANGE INDICATION - An apparatus with time controlled color change indication comprises an apparatus includes a disposable, limited or restricted use product and an oxygen sensing color changeable dye disposed on a portion of the apparatus, the dye being translucent or having a first color upon application and for a defined time thereafter and the dye changing color after exposure to oxygen for the defined time. For example, a packaging for containing a product for human consumption has a portion with a color changeable dye disposed thereon. The dye changes color after being exposed to oxygen for a controlled and predetermined period of time indicating that the product for human consumption should no longer be consume or has decreased in freshness, quality of taste or potency. | 2015-12-03 |
20150346173 | TOTAL PRESSURE AND TOTAL TEMPERATURE MEASUREMENT IN WET GAS CONDITION - The present probes are miniaturized, total pressure and total temperature, probes able to measure in wet gas conditions, two phase flow, inside pipes or compressor. When measuring in wet gas conditions, the probe measures accurately with a defined amount of liquid phase. Differently from standard probes, such probes are able to generate a gas expansion on the external side of the cup. This guarantees the appropriate purging of the liquid fraction of the flow from the cup, letting the total pressure measurement of the gas. The total temperature probe, beside the purging of the liquid collected, has a miniaturized cup in order to protect the measuring element from the direct impact of the liquid droplets. This permits to measure the total temperature of the gas, without influence of the liquid fraction of the flow. | 2015-12-03 |
20150346174 | EXPOSURE MONITORING - A filter medium of an air purifying respirator captures one or more substances from the air in a worker's environment as the worked breathes. Air contaminants captured by the respirator filter media can be subsequently analyzed and measured. An air flow meter placed at an air channel of the respirator measures air flow and/or total air volume inspired by the worker wearing the respirator. Personal chemical exposure of the worker can be assessed from the filter media measurements and air flow data. | 2015-12-03 |
20150346175 | PROCESS FOR DETERMINING A CARBON CREDIT SURPLUS OR DEFICIT - In an apparatus and system for monitoring and communicating emissions data for a diesel engine, an exhaust gas analyzer uses infrared light to measure the quantity of trace gases and particulates in an exhaust gas outlet from a diesel engine. The gas analyzer includes a logic processor to interpret the measured data and a memory device to store the measured data. A radio transmitter, cellular data transmitter, or Smartphone transmits the measurement data. In a diagnostic and monitoring system for a diesel engine, the exhaust gas analyzer is in contact with the exhaust gases from the diesel engine, preferably in the tailpipe. | 2015-12-03 |
20150346176 | METHODS - The present invention relates to a method of analysing the components of a flavour sample comprising the steps of a) preparing a composition comprising a number (n) of aroma compounds to form a replica of a flavour; b) preparing a further composition comprising the same aroma and/or taste compounds with one of the components being reduced in amount by from 5 to 95% compared to the amount in the first composition; and c) comparing the aroma and/or taste of the first and second compositions. | 2015-12-03 |
20150346177 | TEST STRIP AND OPTICAL ANALYSIS SYSTEM - An example test strip includes a liquid absorbing material, a reagent test portion, and an outer shell that encompasses the liquid absorbing material and the reagent test portion. The liquid absorbing material extends along the test strip and is designed to communicate liquid received through the outer shell to the reagent test portion. The outer shell is formed from a liquid impermeable material and includes a window area that allows an externally provided optical sensor to acquire an optical signal from the reagent test portion. The outer shell also includes a liquid transmission portion that is configured to allow liquid to flow into the area encompassed by the outer shell. | 2015-12-03 |
20150346178 | System and Method to Measure Dissolved Gases in Liquid - A high-resolution in situ sensing system and method for providing continuous measurements of at least one dissolved gas including a sample liquid processing cell having at least a first conduit defining a first passage with at least one gas-permeable wall capable of passing the at least one pre-selected dissolved gas from the sample liquid into a reagent fluid. The at least one gas-permeable wall substantially resists flow of the sample liquid therethrough. Reagent fluid is directed through the first conduit while moving the sample liquid and the reagent fluid relative to each other in one of a concurrent and a countercurrent flow relationship to achieve either partial or full equilibration between the sample liquid and reagent fluid to generate at least partially equilibrated reagent fluid in a substantially continuous manner. | 2015-12-03 |
20150346179 | METHOD OF ASSESSING AT LEAST ONE PETROLEUM CHARACTERISTIC OF A ROCK SAMPLE - The invention is a Method of assessing at least one petroleum characteristic of a rock sample. Starting from a temperature ranging between 50° C. and 120° C., the temperature of a rock sample is raised to a temperature ranging between 180° C. and 220° C. which is maintained for a predetermined time duration. The temperature of the sample is increased to a temperature ranging between 330° C. and 370° C. which is maintained for a predetermined time duration. The temperature of the sample is then raised to a temperature ranging between 630° C. and 670° C. Three quantities representative of the amount of hydrocarbon compounds released during the temperature change stages are measured and at least one petroleum characteristic of the sample is deduced from these quantities. | 2015-12-03 |
20150346180 | FUEL PROPERTY JUDGMENT DEVICE AND METHOD OF JUDGING FUEL PROPERTY - A fuel injection system has a common rail storing fuel, a fuel injector injecting the fuel, a fuel-passage supplying the fuel to the fuel injector, and a fuel-pressure sensor detecting a fuel pressure. An ECU acquires a waveform of a fuel pressure representing a change of a fuel pressure based on the detected fuel pressure at the fuel injection. The ECU calculates a speed of a fuel pressure wave forming the waveform of the fuel pressure based on a period of a pulsation of the waveform of the fuel pressure and a fuel passage length, and a fuel density based on the speed of the fuel pressure wave. The ECU further calculates a fuel cetane number, and a kinematic viscosity of the fuel based on the fuel density and the fuel cetane number. The ECU judges fuel properties based on the kinematic viscosity of the fuel. | 2015-12-03 |
20150346181 | DEVICE AND SYSTEM TO DETERMINE ENGINE LUBRICATION HEALTH - A health analysis system for an engine lubrication system is disclosed. The engine lubrication system includes a sump, a lubricant quality sensor to detect quality related to at least one parameter of a lubricant, and a conduit. The health analysis system includes a bypass line connected from the conduit to the sump to facilitate passage of a sample engine lubricant. Further, a patch containment assembly is included that has a first housing with a first passage. A second housing, defining a second passage, is removably connectable to the first housing. Moreover, a patch member is removably positioned within one of the first housing or the second housing. The first passage is in fluid communication with the second passage through the patch member. | 2015-12-03 |
20150346182 | Portable System and Method for Quality Assurance Testing of Asphalt Binders - A system includes a voltage supply configured to supply a drive voltage. A flexible device connects with the voltage supply. The flexible device is configured to be embedded into a material, e.g., a viscoelastic material. A strain gage connects with the flexible device, and the strain gage is configured to measure a flexing of the flexible device. A processor connects with the strain gage. The processor is configured to determine a measured strain and a phase shift between the drive voltage and the strain when voltage is supplied to the flexible device to produce a fingerprint of the material. The processor can be configured to determine G* and δ to produce a fingerprint of the material. | 2015-12-03 |
20150346183 | C PEPTIDE DETECTION BY MASS SPECTROMETRY - Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques. The present invention provides methods for detecting the presence or amount of C peptide in a sample by mass spectrometry. | 2015-12-03 |
20150346184 | Analyte Sensor Ports - The present disclosure provides a contamination resistant sensor port which includes one or more sealing members positioned so as to limit and/or prevent internal contamination of the sensor port with fluids and/or particles present in the environment outside the sensor port. | 2015-12-03 |
20150346185 | DIAGNOSIS OF CYSTIC FIBROSIS - The present invention provides materials and methods for diagnosis of cystic fibrosis, including atypical cystic fibrosis. | 2015-12-03 |
20150346186 | INTEGRATED DISEASE DIAGNOSTIC SYSTEM USING MATRIX-ASSISTED LASER DESORPTION/IONIZATION TIME-OF-FLIGHT MASS SPECTROMETER - A disease diagnostic system where a sample preparation unit and/or a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer (MALDI-TOF MS) data generation unit may be integrated in one system or a set of a system to improve the user-friendliness of the system. The system may include a sample preparation unit with processing modules and/or a handler to move samples in an autonomous manner to enhance reproducibility of measurement data and/or user-friendliness. A different set of processing modules may be selected for a particular disease type (e.g. such as cancer) to be diagnosed. The system may be used to identify biomaterials such as bacteria, virus, and fungi from body fluids like blood, urine, and saliva and other cells. | 2015-12-03 |
20150346187 | In Vitro Embryo Blastocyst Prediction Methods - Methods, compositions and kits for determining the likelihood of reaching the blastocyst stage for one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans. | 2015-12-03 |
20150346188 | STABILIZED NANOPORE AND MICROPORE STRUCTURES AND METHODS FOR MAKING AND USING THE SAME - The invention relates generally to nanopore and micropore structures, methods for making the structures and use of the structures. In particular, the invention provides nanopore structures (e.g., containing lipid bilayers) in combination with one or more osmoprotective compounds and methods of making and using the same. Compositions and methods of the invention fmd use in a wide range of applications including molecular biology and medical science. | 2015-12-03 |
20150346189 | POINT OF CARE SEPSIS ASSAY DEVICE AND METHOD - Disclosed is a point of care sepsis assay comprising a disposable assay cartridge with a sample inlet for a blood sample, a filter to isolate blood plasma, a source of multivalent cations to cause a turbidity change in the plasma sample and a transparent window to measure the change in turbidity and the use of said assay in the diagnosis of sepsis. | 2015-12-03 |
20150346190 | Gas Sensor Element - Described herein are sensor elements for detecting the presence of organic materials comprising a boron doped n-type semiconductor material with decrease in resistivity upon organic materials exposure with increase in resistivity upon organic materials exposure | 2015-12-03 |
20150346191 | COMPOSITIONS AND METHODS FOR PROGNOSIS AND TREATMENT OF NEOPLASM - A protocol for assessing the prognosis for a patient diagnosed with a neoplasm or suspected of having a neoplasm is provided herein. The protocol involves the steps of determining a mitotic cells to proliferating cells ratio (M:P ratio) in a neoplastic tissue sample obtained from the patient and producing a prognosis for the neoplasm based on the M:P ratio. | 2015-12-03 |
20150346192 | Intracellular Phenotypic Screening - The present invention relates to a method for identifying a cellular target involved in a cell phenotype comprising identifying an intrabody which can modify a cell phenotype and identifying a direct or indirect cellular target of the intrabody. The present invention also relates to intrabodies 3H2-1, 3H2-VH and 5H4 which are capable of inhibiting the degranulation reaction in mast cells triggered by an allergic stimulus, and especially to intrabodies 3H2-1 and 5H4 which are capable of directly or indirectly targeting a protein of the ABCF1 family and of the C120RF4 family respectively. The present invention also relates to ABCF1 and C120RF4 inhibitors for use in therapy, in particular for treating allergic and/or inflammatory conditions. | 2015-12-03 |
20150346193 | SYSTEM AND METHOD FOR LABELING ESSENTIAL OILS - The disclosure extends to systems and methods of labeling compounds of essential oils with a marker. In an implementation, the labeling of the compounds of essential oils may comprise using a fluorescent dye that covalently links the hydroxyl group to the fluorescent dye, such that the compound may be detected using a fluorescence microscope. | 2015-12-03 |
20150346194 | Deglycosylation Reagents and Methods - Compositions and methods are provided for efficiently preparing a completely deglycosylated antibody where efficiency is measured in relative amounts of reagents in soluble or lyophilized form, and time and temperature of the reaction. Compositions and methods are also provided for separating substantially all N-linked glycans from a glycosylated antibody and for preserving functionality of the antibody. The methods are compatible with glycan labeling and protease digestion without the need for prior purification steps. | 2015-12-03 |
20150346195 | SCREENING OF CONJUGATED ANTIBODIES - Provided is a method for the functionalization of immunoglobulins through the use of transglutaminase, including methods for screening functionalized antibodies for characteristics of interest, antibody compositions comprising a plurality of functionalized antibodies, and functionalized antibodies with rodent constant regions. | 2015-12-03 |
20150346196 | ANTIBODY COMPOSITION, KIT FOR PREPARING ANTIBODY COMPOSITION, AND IMMUNOSTAINING METHOD - An antibody composition, which is an aspect of the present invention, contains at least one compound selected from the group consisting of urea and urea derivatives, the compound being contained in the antibody composition at a concentration of not less than 0.1 M and less than 1 M, the antibody composition being a solution. | 2015-12-03 |
20150346197 | APPARATUS, SYSTEMS AND METHODS FOR SENSING AN ANALYTE SUCH AS ETHANOL - According to one aspect, a system for sensing ethanol from human skin, that comprises at least one apparatus for sensing ethanol and a coupling matrix readout extraction unit for performing a method of extracting a coupling-matrix readout. The at least one sensing apparatus and the coupling matrix readout extraction may be mounted on a substrate. The substrate may be adapted such that it can be formed into a wearable accessory that can be worn by a human subject. When the wearable accessory is worn by the human subject such that the subject provides a skin tissue sample to the accessory, the presence or concentration of ethanol and other compounds may be determined from the vapour associated with the tissue sample. | 2015-12-03 |
20150346198 | Lipid Membrane Enveloped Particles with Membrane Proteins - The present invention relates to model lipid bilayers surrounding a nano- or microsized particle comprising, membrane proteins immobilized to the surface of the particle and a sheet of a lipid bilayer interspaced between the membrane proteins and enveloping said particle, wherein said membrane protein is immobilized to the surface of the particle by a linker molecule with a length of at most 5.5 nm, as well as method of using said particles in membrane protein ligand binding or activity assays. | 2015-12-03 |
20150346199 | METHODS AND COMPOSITIONS FOR HYBRID MICROFLUIDIC DEVICES INTEGRATED WITH NANO-BIOSENSORS - Certain embodiments are directed to paper/polymer hybrid microfluidic devices integrated with nano-biosensors for pathogen detection and infectious disease diagnosis. | 2015-12-03 |
20150346200 | ANTIBODIES TO MICROBIOME, STRESS FACTORS AND MAST CELL MARKERS AS DIAGNOSTIC MARKERS FOR IBS - The present invention provides methods for aiding in the diagnosis of irritable bowel syndrome (IBS) in an individual. In particular, the present invention is useful for determining whether a sample from an individual is an IBS sample or a healthy control sample using a statistical algorithm. Thus, the present invention provides an accurate diagnostic prediction of IBS and is useful for guiding treatment decisions. | 2015-12-03 |
20150346201 | SYSTEM AND METHOD FOR PICOLITER VOLUME MICROFLUIDIC DIAGNOSTICS - The present invention provides a method for a picoliter volume microfluidic assay. The method includes the steps of providing a first solution comprising a sensor, preparing a sample comprising at least one analyte, and combining the sample with an indicator, thereby forming a second solution. The method further includes co-encapsulating the first solution and the second solution in a plurality of droplets with a microfluidic device, incubating the plurality of droplets, thereby forming at least one complex comprising the sensor, at least one analyte and indicator, and detecting the at least one complex. A primary signal associated with the at least one complex is distinguishable from a background signal associated with at least one of the sensor, at least one analyte and indicator individually. | 2015-12-03 |
20150346202 | STABILIZED CHEMILUMINESCENT SYSTEM - The present invention relate to formulations, systems, kits and methods for chemiluminescence assays to detect the catalytic activity of a peroxidase. The present invention provides formulations and methods for chemiluminescence reactions that have significantly improved signal duration, which signal lasts for hours. | 2015-12-03 |
20150346203 | Methods and Compositions for Use of Neutrophil Elastase and Proteinase 3 as Diagnostic Biomarkers - Methods and compositions for identifying autoimmune diabetes are provided. One aspect provides a method for the evaluation of risk and progression of autoimmune diabetes in mammalian subjects. The method includes measuring the enzymatic activities and/or protein concentrations of neutrophil elastase and proteinase 3 in a subject and comparing the measured levels of these proteases to respective reference levels. | 2015-12-03 |
20150346204 | MEK Mutations Conferring Resistance to MEK Inhibitors - The present invention relates to methods, compositions and kits concerning resistance to treatment with an anti-cancer agent, specifically an inhibitor of MEK. In particular embodiments, the invention concerns mutations in a MEK sequence that confer resistance to a MEK inhibitor. Identification of such mutations in a MEK sequence allows the identification and design of second-generation MEK inhibitors. Methods and kits for detecting the presence of a mutant MEK sequence in a sample are also provided. | 2015-12-03 |
20150346205 | METHODS OF SUBCLASSIFICATION OF DUCTAL CARCINOMA IN SITU OF THE BREAST - Provided herein are methods of determining the aggressiveness or indolence of a ductal carcinoma in situ lesion. Also provided are methods of development treatment plans for subjects with a ductal carcinoma in situ lesion based on the aggressiveness of the lesion. | 2015-12-03 |
20150346206 | Method of Identifying Treatment Responsive Non-Small Cell Lung Cancer Using Anaplastic Lymphoma Kinase (ALK) as a Marker - Disclosed herein are methods for identifying a subject as having NSCLC that is predicted or is likely to respond to treatment with an ALK inhibitor, for example crizotinib. The methods include identifying a sample including NSCLC tumor cells as ALK-positive or ALK-negative using immunohistochemistry (IBC) and scoring methods disclosed herein. A subject is identified as having NSCLC likely to respond to treatment with an ALK inhibitor if the sample is identified as ALK-positive and is identified as having NSCLC not likely to respond to treatment with an ALK inhibitor if the sample is identified as ALK-negative. According to certain embodiments of the methods, subjects predicted to respond to an ALK inhibitor may then be treated with an ALK inhibitor such as crizotinib. | 2015-12-03 |
20150346207 | A method for predicting the risk of getting cancer or diagnosing cancer in a subject - Subject matter of the present invention is a method for predicting the risk of getting cancer in a subject that does not suffer from cancer or alternatively diagnosing cancer in a subject comprising:
| 2015-12-03 |
20150346208 | PD-L1 Antibodies and Uses Thereof - Provided herein are novel PD-L1 antibodies and methods for using the same for diagnosing a medical condition associated with elevated PD-L1 levels (e.g., cancer) in subjects in need thereof and antigen binding fragments thereof. The PD-L1 antibodies and antigen binding fragments are also useful in evaluating the efficacy of a particular therapeutic regime in a subject diagnosed as having a PD-L1-related medical condition. | 2015-12-03 |
20150346209 | METHOD OF LABELING SULFENIC ACID-CONTAINING PROTEINS AND PEPTIDES - A method of labeling a sulfenic acid (—SOH) group of a cysteine residue in a protein or peptide, comprises contacting said protein or peptide with a beta-ketoester to covalently couple said beta-ketoester to said cysteine residue and form a beta-ketoester-labeled cysteine residue in said protein or peptide. | 2015-12-03 |
20150346210 | MULTIPLEX ASSAY FOR IMPROVED SCORING OF TUMOR TISSUES STAINED FOR PD-L1 - Multiplex assays for improved scoring of tumor tissues stained with PD-L1 featuring PD-L1 staining in a first color plus staining of one or more differentiating markers, such as a marker specific for tumor cells and a marker specific for immune cells, are disclosed. The differentiation between the tumor cells and immune cells may improve the ease of scoring, the accuracy and speed of scoring, and the reproducibility of scoring of PD-L1 positive samples for therapy purposes. | 2015-12-03 |
20150346211 | LATERAL FLOW IMMUNOASSAY FOR COMPLEMENT ACTIVATION AND METHODS OF USE FOR POINT-OF-CARE ASSESSMENT OF COMPLEMENT-ASSOCIATED DISORDERS - A method for treating an individual at risk for a complement-associated disorder is provided, the method including: (a) obtaining a sample of a body fluid from the individual; (b) measuring a complement activation level in the sample via a point-of-care lateral flow immunoassay; (c) correlating the complement activation level in the sample to a risk of a complement-associated disorder by comparing the complement activation level in the sample to a reference level in a control, wherein a deviation in complement activation level in the sample compared to the reference level in the control indicates the individual is at risk for a complement-associated disorder; (d) selecting a treatment for the individual, based on the correlating of step (c); and (e) treating the individual with the treatment selected in accordance with step (d). Lateral flow immunoassays for the qualitative and quantitative point-of-care detection of complement activation and a method of monitoring an individual suffering from a complement-associated disorder are also provided herein. | 2015-12-03 |
20150346212 | SYSTEM FOR DETECTION OF A COMPONENT IN A FLUID - The invention provides a system for detection of a component in a fluid, the system comprising a detector configured to detect presence of the component in the fluid, the detector being partially covered by a fluid-protective seal wherein only a specimen sampling region is uncovered by the fluid-protective seal. The system can be fully submerged in water and still retain its functionality. | 2015-12-03 |
20150346213 | PLASMA CYTOCHROME C AS A BIOMARKER FOR MITOCHONDRIAL TOXICITY DURING ANTIRETROVIRAL THERAPY - The present invention relates to the discovery that measurement of the level of cytochrome c (Cyt-C) in the plasma can be used as a diagnostic signature to predict antiretroviral therapy (ART) toxicity in human immunodeficiency virus (HIV) infected patients. Thus, in various embodiments described herein, the methods of the invention relate to methods of diagnosing a HIV patient with ART toxicity, methods of predicting a patient's risk of having or developing toxicity for ART, methods of assessing if a patient will benefit from a change in the treatment strategies by adjusting the dosage and/or changing the medication or even terminating of ART, and methods of predicting antiretroviral drugs propensity for causing mitochondrial toxicity. Furthermore, the invention encompasses a diagnostic kit for carrying out the aforementioned methods. | 2015-12-03 |