49th week of 2009 patent applcation highlights part 56 |
Patent application number | Title | Published |
20090298676 | Unimolocular Micelles Containing Metal Nanoparticles and their Use as Catalyst for Synthesis of Carbon-Carbon-Bonds - Disclosed are metal nanoparticle containing unimolecular micelles comprising selected star-shaped block-copolymers. These unimolecular micelles can be used as catalysts in coupling reactions forming carbon-carbon-bonds, for example as catalysts in the Heck reaction. | 2009-12-03 |
20090298677 | Method of Making Hydroprocessing Catalyst - A chelated hydroprocessing catalyst exhibiting low moisture is obtained by hearing an impregnated, calcined carrier to a temperature higher than 200° C. and less than a temperature and for a period of time that would cause substantial decomposition of the chelating agent. | 2009-12-03 |
20090298678 | STRENGTHENING IRON FISCHER-TROPSCH CATALYST BY CO-FEEDING IRON NITRATE AND PRECIPITATING AGENT OR SEPARATELY PRECIPITATING FROM FERROUS NITRATE AND FERRIC NITRATE SOLUTIONS - A method of producing a catalyst precursor comprising iron phases by co-feeding a ferrous nitrate solution and a precipitation agent into a ferric nitrate solution to produce a precipitation solution having a desired ferrous:ferric nitrate ratio and from which catalyst precursor precipitates; co-feeding a ferric nitrate solution and a precipitation agent into a ferrous nitrate solution to produce a precipitation solution having a desired ferrous:ferric nitrate ratio and from which catalyst precursor precipitates; or precipitating a ferrous precipitate from a ferrous nitrate solution by contacting the ferrous nitrate solution with a first precipitation agent; precipitating a ferric precipitate from ferric nitrate solution by contacting the ferric nitrate solution with a second precipitation agent and combining the ferrous and ferric precipitates to form the catalyst precursor, wherein the ratio of ferrous:ferric precipitates is a desired ratio. | 2009-12-03 |
20090298679 | PHOTO-ENERGY TRANSFORMATION CATALYSTS AND METHODS FOR FABRICATING THE SAME - Photo energy transformation catalysts and methods for fabricating the same are provided. The method includes mixing a solution containing a positive valence element of Group IB, a solution containing a positive valence element of Group IIIA, and a solution containing a negative valence element of Group VIA to obtain a composition and forming a film from the composition by liquid phase deposition, wherein the film contains compounds including the elements of Group IB, Group IIIA, and Group VIA. | 2009-12-03 |
20090298680 | ALUMINUM PRODUCT AND METHOD FOR PRODUCING SAME - An aluminum product includes an aluminum substrate, a porous alumina film formed on the aluminum substrate, and a photo-catalyst film. The alumina film has an array of pores defined on a surface thereof. The photo-catalyst film is formed on the surface of the alumina film and inner walls of the alumina film located in the pores. An exemplary method for producing the aluminum product is also provided. | 2009-12-03 |
20090298681 | STABLE FERROUS-FERRIC NITRATE SOLUTIONS FOR FISCHER-TROPSCH CATALYST PREPARATION - A method of producing stable ferrous nitrate solution by dissolving iron in nitric acid to form a ferrous nitrate solution and maintaining the solution at a first temperature for a first time period, whereby the Fe(II) content of the ferrous nitrate solution changes by less than about 2% over a second time period. A method of producing stable Fe(II)/Fe(III) nitrate solution comprising ferrous nitrate and ferric nitrate and having a desired ratio of ferrous iron to ferric iron, including obtaining a stable ferrous nitrate solution; dissolving iron in nitric acid to form a ferric nitrate solution; maintaining the ferric nitrate solution at a second temperature for a third time period; and combining amounts of stable ferrous nitrate solution and ferric nitrate solution to produce the stable Fe(II)/Fe(III) nitrate solution. A method of preparing an iron catalyst is also described. | 2009-12-03 |
20090298682 | CATALYST COMPOSITIONS AND PROCESS FOR OXYCHLORINATION - Oxychlorination catalyst compositions which include a catalytically effective amount of an oxychlorination catalyst and a diluent having certain chemical composition and/or physical properties are disclosed. Processes using such oxychlorination catalyst compositions are also described. Some oxychlorination catalyst compositions and processes disclosed herein can increase the optimal operating temperature, and thereby increase the production capacity of an existing reactor, such as a fluid-bed reactor, compared to other oxychlorination catalyst compositions. | 2009-12-03 |
20090298683 | PRODUCTION OF A MATERIAL COMPRISING A MIXTURE OF NOBLE METAL NANOPARTICLES AND RARE-EARTH OXIDE NANOPARTICLES - The invention relates to the production of a material comprising a mixture of noble metal nanoparticles and rare-earth oxide nanoparticles. The process comprises the following successive steps:
| 2009-12-03 |
20090298684 | METHOD OF MANUFACTURING MULTICOMPONENT NANOPARTICLES - Multicomponent nanoparticles include two or more dissimilar components selected from different members of the group of noble metals, base transition metals, alkali earth metals, and rare earth metals and/or different groups of the periodic table of elements. The two or more dissimilar components are dispersed using a polyfunctional dispersing agent such that the multicomponent nanoparticles have a substantially uniform distribution of the two or more dissimilar components. The polyfunctional dispersing agent may include organic molecules, polymers, oligomers, or salts of these. The molecules of the dispersing agent bind to the dissimilar components to overcome same-component attraction, thereby allowing the dissimilar components to form multicomponent nanoparticles. Dissimilar components such as iron and platinum can be alloyed together using the dispersing agent to form substantially uniform multicomponent nanoparticles, which can be used alone or with a support. At least a portion of the dispersing agent is removed by reduction and/or oxidation. | 2009-12-03 |
20090298685 | WATER ABSORBING AGENT, WATER ABSORBENT CORE USING THE AGENT, AND MANUFACTURING METHOD FOR WATER ABSORBING AGENT - A water absorbing agent of the present invention has an internal crosslinking structure obtained by polymerization of a water-soluble unsaturated monomer. The agent satisfies conditions (a) to (d): (a) the agent contains water-insoluble inorganic particles at an amount of from 10 ppm to 1,900 ppm inclusive; (b) the agent contains 5 mass % or less particles which have such a size that they can pass through a sieve having a mesh opening size of 150 μm; (c) the agent has an absorbency against a pressure of 4.83 kPa (AAP) of 18 g/g or more; and (d) the water-insoluble inorganic particles reside on a surface of the water absorbing resin or near the surface. | 2009-12-03 |
20090298686 | Metallic carrier for catalysts or particle separators and the use of this carrier - A metallic carrier for a catalytic converter or particle separator and the use of a metallic carrier for exhaust gas cleaning of internal combustion engines, especially diesel engines, is provided. The metallic carrier comprises an aluminum alloy having an aluminum content of 75 to 99.5 percent by mass. The metallic carrier helps achieve an advantageous reduction in the mass of the carrier and thermal capacity, as a result of which the light-off temperature is reached more rapidly. The reduction of mass and thermal capacity is not at the expense of a reduction in the catalytic carrier surface. | 2009-12-03 |
20090298687 | PRINTABLE IDENTIFICATION MEDIUM FOR USE WITH THERMAL PRINTERS - An identification device in the form of a wristband, labels, tags or cards, including a clear thermal sensitive coating laminated between a clear plastic coating and a liner ply having colored regions or printed matter. The colored regions or printed matter is visible through the clear thermal sensitive coating and clear plastic coating until the thermal sensitive coating is activated and becomes selectively opaque. The clear plastic coating having a uniform thickness allows for reliable thermal printing on the thermal sensitive coating with the clear plastic coating in place. | 2009-12-03 |
20090298688 | Slow-Release Fertilizer and Method of Making and Using Same - There is disclosed a fertilizer composition comprising a water-insoluble slow-release reacted nitrogen fertilizer and an effective amount of a water-soluble, non-aromatic poly(amino acid) of the group poly(aspartic acid), poly(glutamic acid), poly(glycine), poly(lysine) a copolymer of cystein and glutamic acid and a terpolymer of cystein and glutamic acid and aspartic acid, wherein the poly(amino acid) has a molecular size larger than that which can be absorbed by a plant. A method of making and using the fertilizer composition is also disclosed. | 2009-12-03 |
20090298689 | Method of suspending weed growth in soil - Introducing chlorine dioxide solution into an agricultural soil in an amount effective to suspend weed and pathogen growth in the soil. The chlorine dioxide is allowed to decompose in the soil. Then, a crop is planted in the treated soil. The decomposed chlorine dioxide provides nutrients for the crops as they grow. | 2009-12-03 |
20090298690 | VINASSES-DERIVED PRODUCT AND METHOD OF PRODUCTION THEREOF - The present invention provides a product for agricultural use in the form of granules or pellets, characterised by comprising at least 30% (w/w) of vinasses and/or sludge measured as a dry extract of vinasses and/or sludge, and an organic or inorganic solid support. In addition, the present invention provides a procedure for producing said product, its use in agriculture, stockbreeding or as biodiesel. | 2009-12-03 |
20090298691 | METHODS AND COMPOSITIONS FOR CONTROL OF AQUATIC WEEDS USING HERBICIDAL COMBINATIONS WITH FLURIDONE - Described are preferred methods and compositions for controlling aquatic weeds that involve the use of fluridone in combination with at least one additional selected herbicidal agent, which is preferably penoxsulam, bensulfuron-methyl, bispyribac-sodium, and imazamox (ALS inhibitors). Additional preferred compositions and methods can further involve the use of triclopyr or 2,4-d (auxinic herbicides) in the herbicidal composition. Preferred herbicidal combinations allow for enhanced control and/or selectivity when treating a body of water to control a target weed population, such as a hydrilla, watermilfoil, curlyleaf pondweed, and/or Brazilian elodea weed populations. | 2009-12-03 |
20090298692 | COMPOSITIONS AND METHODS FOR CONTROLLING THE DIRECTION OF GROWTH OF PLANTS WITH ROOTLETS - Described herein are compositions including an herbicide, a capsaicinoid, and an acrylic for controlling the direction of growth of plants with rootlets. Also described herein are methods for making and using the compositions. | 2009-12-03 |
20090298693 | CONTROL OF AQUATIC WEEDS WITH ENDOTHALL AND ALS-INHIBITING AGENT - Described are preferred methods and compositions for controlling aquatic weeds that involve the use of an ALS-inhibiting herbicidal agent such as penoxsulam in combination with endothall. Preferred herbicidal combinations allow for enhanced control when treating a body of water to control a target weed population, such as hydrilla. | 2009-12-03 |
20090298694 | Herbicidal Composition and Method for Removing Unwanted Foliage - This invention relates to a method of preparing a spray tank mix of glyphosate comprising (a) providing glyphosate acid concentrate; (b) providing an alkaline composition; and (c) forming a mixture of glyphosate acid concentrate and alkaline composition in the spray tank by addition of a composition comprising the glyphosate acid concentrate to a diluted aqueous mixture of the alkaline composition. | 2009-12-03 |
20090298695 | Low use rate agricultural compositions and methods for use - A substantially dry, flowable adjuvant compositions comprising, based on 100 parts by weight (“pbw”) of the adjuvant composition: (a) from about 25 pbw to about 75 pbw of a polysaccharide and (b) from about 75 pbw to about 20 pbw of a salt composition. In one embodiment, the salt composition is diammonium hydrogen phosphate, sodium carbonate or a combination thereof, and the polysaccharide is a derivatized guar. Also disclosed are methods of preparing such agricultural compositions comprising adding, to a heel solution, (a) a water dispersible adjuvant composition, in an amount effective to provide deposition and/or drift control properties, comprising, based on 100 pbw of the adjuvant composition: (i) from about 25 pbw to about 75 pbw of a polysaccharide, and (ii) from about 75 pbw to about 20 pbw of a salt composition, wherein an aqueous solution of the adjuvant composition has a pH value of between about 7 and about 12, and (b) an effective amount of an active. The adjuvant composition can further comprise (iii) from about 20 pbw to about 30 pbw of a dispersing agent, wherein typically the dispersing agent is sodium polyacrylate. | 2009-12-03 |
20090298696 | Low resistance splice for high temperature superconductor wires - Under one aspect, a laminated, spliced superconductor wire includes a superconductor joint, which includes (i) first and second superconductor wires, each wire including a substrate, a superconductor layer overlying the substrate, and a cap layer overlying the superconductor layer; and (ii) a conductive bridge, the conductive bridge including a substrate, a superconductor layer overlying the substrate, and a cap layer overlying the superconductor layer, wherein the cap layer of the conductive bridge is in electrically conductive contact with a portion of the cap layer of each of the first and second superconductor wires through an electrically conductive bonding material. The spliced wire also includes (b) a stabilizer structure surrounding at least a portion of the superconductor joint, wherein the superconductor joint is in electrical contact with the stabilizer structure; and (c) a substantially nonporous electrically conductive filler, wherein the filler substantially surrounds the superconductor joint. | 2009-12-03 |
20090298697 | MULTIFILAMENTARY SUPERCONDUCTING ARTICLES AND METHODS OF FORMING THEREOF - A superconducting article is provided that includes a multifilamentary superconducting tape segment having a substrate tape, a buffer layer overlying the substrate, and filaments comprising a high temperature superconducting (HTS) material overlying the buffer layer. The filaments extend along a length of the substrate and are laterally spaced apart from an adjacent filament by a space. The multifilamentary superconducting tape segment comprises a critical current retention ratio is at least about 0.4. | 2009-12-03 |
20090298698 | HIGH-TEMPERATURE SUPERCONDUCTOR LAYER ARRANGEMENT - A high-temperature superconductor layer arrangement includes at least one substrate and a textured buffer layer made of oxidic material that permits textured growth of a high-temperature superconductor. Surprisingly, a layer of the buffer material made of a rare-earth element cerium oxide containing lanthanum as the rare-earth element may be used to produce a homogeneous buffer layer in just one coating operation, where appropriate. The buffer layer material may be a rare-earth oxide of the general formula: Ln′ | 2009-12-03 |
20090298699 | PROCESS FOR PRODUCING RAW MATERIAL POWDER FOR OXIDE SUPERCONDUCTOR - The invention offers a production method of a material powder of an oxide superconductor. The production method is provided with both a step of producing a dry powder by removing solvent from a solution containing elements for constituting the oxide superconductor and a step of producing oxides of the elements for constituting the oxide superconductor by scattering the dry powder in a high-temperature furnace. Provided with the above steps, the production method not only can achieve the uniform presence of the elements for constituting the oxide superconductor but also enables the mass production of the material powder. | 2009-12-03 |
20090298700 | MONOCLONAL ANTIBODY SPECIFICALLY RECOGNIZING MODIFICATION SITE AFTER TRANSLATION OF P53 AND KIT FOR ASSAYING MODIFICATION SITE CONTAINING THE SAME - The present invention provides a monoclonal antibody recognizing modification after translation of p53 in a manner specific to a modification site, an antibody microarray comprising the antibody immobilized on a substrate, etc. Disclosed is a monoclonal antibody which reacts specifically with a peptide consisting of an amino acid sequence of at least 6 consecutive amino acids containing a predetermined amino acid residue of the amino acid sequence represented by SEQ ID NO: 1, wherein the amino acid residue is phosphorylated or acetylated, or with a peptide having one to several arbitrary amino acids added to the above peptide, but does not react with the above peptide which is not phosphorylated or acetylated. | 2009-12-03 |
20090298701 | PREDICTORS OF PATIENT RESPONSE TO TREATMENT WITH EGF RECEPTOR INHIBITORS - The present invention provides methods and compositions to facilitate determining whether an EGFR-expressing cancer in an individual is an EGFR inhibitor-responsive cancer, as well as methods for determining the likelihood that a patient having an EGFR-expressing cancer will exhibit a beneficial response to an EGFR inhibitor therapy. The methods generally involve determining a normalized expression level of a gene product that correlates with EGFR inhibitor responsiveness. | 2009-12-03 |
20090298702 | NUCLEIC ACID SEQUENCING USING A COMPACTED CODING TECHNIQUE - Methods and apparatuses for nucleic aced sequencing using a compacted code technique are disclosed. In one embodiment, a method includes providing a nucleic acid to be sequenced, determining the identity of each base in a subsequence of bases in the nucleic acid, encoding the identity of the subsequence in a format having a number of bytes that is less than the number of bases, and storing the encoded identity. | 2009-12-03 |
20090298703 | Method for Automated Tissue Analysis - The invention provides an improved method for identifying and interpreting tissue specimens and/or cells derived from tissue specimens. A panel of cell-based reagents provides a number of readouts of cellular states or biomarkers that together define a profile of a diversity of cellular states or biomarkers in a tissue specimen representing the “systems” nature of biology. This cellular profile is interpreted using informatics tools, to identify similarities between specimens, in vivo medical conditions, and suggest options for treating medical conditions. | 2009-12-03 |
20090298704 | Wireless CMOS Biosensor - System and methods for detection and measurement of interactions in microarrays or within a human body are described. The system includes a CMOS sensor which can be placed in a fluidic environment, and is capable of measuring DNA interactions and protein binding kinetics, as well as cellular interactions and signals within the body. The sensor can be placed in close proximity with the sample and eliminates the need for optics, and in some embodiments is a wireless device. | 2009-12-03 |
20090298705 | METHODS AND ASSAYS FOR OVERSULFATED GLYCOSAMINOGLYCANS - Methods and assays for oversulfated glycosaminoglycans are provided. In an embodiment, the present disclosure provides a method for detecting oversulfated glycosaminoglycan (OS-GAG) in a heparin sample. The method comprises placing the heparin sample onto a support comprising immobilized heparin and contacting the heparin sample on the support with a binding compound that attaches to the heparin and forms a heparin-binding compound complex. The binding compound also has a greater affinity for attaching to the OS-GAG than to the heparin in the heparin sample and forms an OS-GAG-binding compound complex. The method can further comprise detecting an amount of the heparin-binding compound complex on the support, and determining an amount of OS-GAG in the heparin sample based on the amount of the heparin-binding compound complex on the support. | 2009-12-03 |
20090298706 | METHOD FOR CELL SURFACE DISPLAYING OF TARGET PROTEINS USING BACILLUS ANTHRACIS EXOSPORIUM - The present invention relates to a method for expressing a target protein on the surface of a microorganism using | 2009-12-03 |
20090298707 | SPARSE MATRIX SYSTEM AND METHOD FOR IDENTIFICATION OF SPECIFIC LIGANDS OR TARGETS - In certain embodiments, this invention pertains to the creation of “Sparse Matrix” libraries of compounds. The sparse matrix libraries of this invention typically span an n-dimensional parameter (property) space at extremely sparse intervals and thereby provide a relatively small library of compounds (e.g., a library of about 200 or fewer compounds) that can be used to quickly and efficiently screen the compound parameter space for one or more desired physical, chemical, or biological properties (e.g., binding specificity, binding avidity, γtoxicity, solubility, mobility, cell permeability, serum half-life, biocompatibility, etc.). | 2009-12-03 |
20090298708 | 2'-DEOXY-2'-FLUORO-BETA-D-ARABINONUCLEOSIDE 5'-TRIPHOSPHATES AND THEIR USE IN ENZYMATIC NUCLEIC ACID SYNTHESIS - The invention relates to arabinose modified nucleoside 5′ triphosphates and to the biosynthesis and amplification of oligonucleotides containing and/or from templates containing arabinose modified nucleosides. The invention further relates to methods of generating modified oligonucleotide libraries for use in selection strategies, such as SELEX. The arabinose modified oligonucleotides of the invention are useful for modulating target nucleic acid expression, such as RNA. | 2009-12-03 |
20090298709 | Assays for determining telomere length and repeated sequence copy number - Methods of detecting copy number of a repeated sequence element, including methods of determining telomere length, are provided. The methods can be multiplexed for detection of repeated sequence element copy number on two or more nucleic acid targets simultaneously. Compositions, kits, and systems related to the methods are also described. | 2009-12-03 |
20090298710 | System for Screening Particles - Screening of a library of particles in vivo and/or in vitro using Polyplex Iterative Combinatorial Optimization (PICO) allows for the design of particles for targeting a specific organ, tissue (e.g., cancer), or cell. Particles may, for example, include different targeting agents (e.g., aptamers or plurality of aptamers) on their surfaces, and the aptamer or aptamers may be evolved to provide better targeting of the particles. Libraries of particles are enriched in characteristics of particles that have been found to migrate to a tissue of interest, be taken up by cells, etc. The process may be repeated to engineer particles of a desired specificity or biological function. | 2009-12-03 |
20090298711 | VASOPRESSIN PATHWAY POLYMORPHISMS AS INDICATORS OF SUBJECT OUTCOME IN CRITICALLY ILL SUBJECTS - The invention provides methods, nucleic acids, compositions and kits for predicting a subject's response to treatment with one or more vasopressin receptor agonists to identify subjects having a greater benefit from treatment with vasopressin receptor agonist(s). The method generally comprises determining a vasopressin pathway associated gene polymorphism genotype(s) of a subject for one or more polymorphisms in the these genes, comparing the determined genotype with known genotypes for the polymorphism that correspond with an improved response genotype to identify potential subjects having an inflammatory condition who are more likely to benefit from treatment with a vasopressin receptor agonist and subsequent to treatment recover from the inflammatory condition. The invention also provides for methods of treating such subjects with vasopressin receptor agonists based on the subject's genotype. | 2009-12-03 |
20090298712 | ARRAY OF MICROCAPSULES FOR CONTROLLED LOADING OF MACROMOLECULES, NANOPARTICLES AND OTHER NANOSCALE ITEMS AND A METHOD OF FABRICATING IT - The invention provides a microcapsule array comprising a plurality of microcapsules immobilised on a surface, optionally in microwells in said surface. Each of the microcapsules comprises an outer layer or shell defining a microcapsule interior, said outer layer having a permeability towards a nanoscale species which is dependent on an environmental condition to which said array is exposed. | 2009-12-03 |
20090298713 | POLYNUCLEOTIDES WHICH ARE OF NATURE B2/D+ A- AND WHICH ARE ISOLATED FROM E. COLI, AND BIOLOGICAL USES OF THESE POLYNUCLEOTIDES AND OF THEIR POLYPEPTIDES - The present invention relates to products which are of nature B2+ A−, isolated from | 2009-12-03 |
20090298714 | NOVEL GLYPHOSATE-N-ACETYLTRANSFERASE (GAT) GENES - Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds, diversification methods involving the novel compounds, and methods of using the compounds. Some of the novel methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate. | 2009-12-03 |
20090298715 | Process Vessel with Integral Evaporator - A process vessel containing both an evaporation zone for evaporating a liquid feed and a treatment zone for treating the resulting vapor comprises an injector having an orifice, the orifice being in the evaporation zone, at least one evaporation surface for evaporating feed and generating vapor, the evaporation surface being located in the evaporation zone, wherein the injector orifice and the evaporation surface are positioned to prevent the formation of a drop at the orifice, a treatment zone for treating the vapor and at least one heater associated with at least a portion of the process vessel. | 2009-12-03 |
20090298716 | COMPOSITE ARRAYS UTILIZING MICROSPHERES WITH A HYBRIDIZATION CHAMBER - The invention relates to sensor compositions comprising a composite array of individual arrays, to allow for simultaneous processing of a number of samples. The invention further provides methods of making and using the composite arrays. The invention further provides a hybridization chamber for use with a composite array. | 2009-12-03 |
20090298717 | MICRO-PARTICLE ARRAY ANALYSIS SYSTEM, MICRO-PARTICLE ARRAY KIT, AND CHEMICAL ANALYSIS METHOD - There is provided means for analyzing organism-related molecules, dealing with multi item analysis, that are captured according to probe species, and for collecting according to the probe species. A magnetic micro-particle array is fixed with magnets that are configured with magnetic micro-particles in a capillary and with an array of glass beads to which DNA probes of different types from each other are immobilized. A syringe pump and a cross valve are operated to circulate a sample solution in the magnetic micro-particle array, which is reacted with probe DNAs on a glass bead with a probe. Subsequently, a washing solution is introduced to wash inside of the capillary. Next, respective beads are measured for fluorescence intensities. Furthermore a particular bead is collected based on results of fluorescence measurement. Target molecules captured on a surface of the collected bead may be separated by heat-denaturation, which then may be subjected to next analysis. | 2009-12-03 |
20090298718 | METHOD AND DEVICE FOR FORMING AN ASSEMBLY - Methods and devices for producing an assembly, and the thus produced assembly, are provided. The assembly may be used in screening applications. In various embodiments, the assembly may comprise a first portion and a second portion. The first portion and second portion may be co-formed or may be separately formed. The assembly may be formed as a blank or may be formed with wells therein. The assembly may be further processed, for example via thermal processing, to form or modify wells in the assembly. In some embodiments, wells in the assembly may have custom volumes, custom shapes, or be arranged in a custom pattern. | 2009-12-03 |
20090298719 | Method for treating subterranean formation with enhanced viscosity foam - A method for treating a subterranean formation by introducing into a gas or oil well a stable foam well treatment fluid which exhibits high viscosity. The well treatment fluid is prepared by first forming a mixture of crosslinking agent and foaming agent and then introducing the mixture to an aqueous fluid containing a crosslinkable polymer followed by the addition of a gas or gaseous liquid. | 2009-12-03 |
20090298720 | Methods for maintaining fracture conductivity - The present invention provides methods to maintain fracture conductivity in subterranean formations. In one embodiment, the methods comprise: providing a first treatment fluid, a second treatment fluid, and a consolidating agent; injecting the first treatment fluid into the subterranean formation at a pressure sufficient to create one or more fractures in the subterranean formation; injecting the second treatment fluid into the subterranean formation to increase the permeability of at least a portion of the subterranean formation comprising at least a portion of the one or more fractures; and injecting the consolidating agent into a portion of the subterranean formation in an amount sufficient to at least partially stabilize at least a portion of the subterranean formation. | 2009-12-03 |
20090298721 | Friction Reducer Performance in Water Containing Multivalent Ions - A variety of methods and compositions are disclosed, including, in one embodiment, a method that comprises: introducing a treatment fluid into a subterranean formation, wherein the treatment fluid comprises water and a concentrated polymer composition comprising a complexing agent and a friction reducing polymer. Also disclosed is a method that comprises combining at least water and a concentrated polymer composition to form a treatment fluid, wherein the concentrated polymer composition comprises a complexing agent and a friction reducing polymer; and introducing the treatment fluid into a subterranean formation. Also disclosed is a concentrated polymer composition comprising: a friction reducing polymer in an amount of about 15% to about 60% by weight of the composition; and a complexing agent. | 2009-12-03 |
20090298722 | Emulsion Breaker - This invention provides acrylate polymers having at least two different ester groups. The ester groups are selected from the following:
| 2009-12-03 |
20090298723 | Method for Treating Wells by Small-Size Additive-Containing Emulsions - The invention relates to a method for treating a reservoir rock, wherein the following stages are carried out:
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20090298724 | Method for Applying Remedial Cement to a Wellbore - A cement composition and method of applying remedial cement to a downhole perforation is described. The method involves the sequential delivery of a phosphate acid activator and a silicate suspension to the perforation to allow in situ reaction of the activator with the binder within the perforation, thereby forming a phosphosilicate plug. | 2009-12-03 |
20090298725 | Enhancing thermal conductivity of fluids with graphite nanoparticles and carbon nanotube - Fluid compositions that have enhanced thermal conductivity, up to 250% greater than their conventional analogues, and methods of preparation for these fluids are identified. The compositions contain at a minimum, a fluid media such as oil or water, and a selected effective amount of carbon nanomaterials necessary to enhance the thermal conductivity of the fluid. One of the preferred carbon nanomaterials is a high thermal conductivity graphite, exceeding that of the neat fluid to be dispersed therein in thermal conductivity, and ground, milled, or naturally prepared with mean particle size less than 500 nm, and preferably less than 200 nm, and most preferably less than 100 nm. The graphite is dispersed in the fluid by one or more of various methods, including ultrasonication, milling, and chemical dispersion. Carbon nanotube with graphitic structure is another preferred source of carbon nanomaterial, although other carbon nanomaterials are acceptable. To confer long term stability, the use of one or more chemical dispersants is preferred. The thermal conductivity enhancement, compared to the fluid without carbon nanomaterial, is somehow proportional to the amount of carbon nanomaterials (carbon nanotubes and/or graphite) added. | 2009-12-03 |
20090298726 | HEAT-RESISTANT BEARING MATERIAL - A heat-resistant bearing material consisting of an austenitic iron matrix alloy should, under high temperatures, have good solid lubricant properties with a high heat resistance and a high creep resistance. To this end, an iron matrix alloy is used, containing a sufficient sulphur part for obtaining a solid lubricant action on the bearing surfaces thereof, and between 1 and 6 wt. % of at least one of the following alloy elements: tungsten (W), cobalt (Co), niobium (Nb), rhenium (Re), molybdenum (Mo), tantalium (Ta), vanadium (V), hafnium (Hf), yttrium (Y), zirconium (Zr), and/or comparably high-melting alloy elements. | 2009-12-03 |
20090298727 | Lubricant Composition for a Final Drive Axle - A lubricant composition for a final drive axle oil comprising an oil of lubricating viscosity, one or more dispersants and one or more phosphorus compounds wherein the kinematic viscosity of the lubricant composition at 100° C. is greater than 10 mm2/s and wherein the amount by weight of the dispersant is greater than the amount by weight of the phosphorus compounds and any sulfur compounds which may optionally be present. | 2009-12-03 |
20090298728 | Lubricants, Greases and Aqueous Fluids Containing Additives Derived from Dimercaptothiadiazole Polymers - The present invention relates to the composition comprising an oil of lubricating viscosity and a mixture of at least one dimercaptothiadiazole polymer or derivative thereof; and at least one carboxylic acid. These products generally show an ability to improve antiwear (including extreme pressure) and corrosion properties in lubricants. | 2009-12-03 |
20090298729 | Star Polymer Lubricating Composition - The invention provides a lubricating composition containing (a) 0.001 wt % to 15 wt % of a polymer with radial or star architecture; (b) an overbased detergent; (c) a dispersant; and (d) an oil of lubricating viscosity. The invention further provides a method for lubricating a mechanical device with the lubricating composition. | 2009-12-03 |
20090298730 | METALWORKING OIL COMPOSITION, METALWORKING METHOD AND METALWORK - The invention provides a metalworking oil composition which is used for a very small amount of oil-feeding type metalworking method, said composition comprising a base oil selected from the group consisting of natural fats and oils, derivatives thereof and synthetic ester oils; and an antirust agent comprising a sorbitan fatty acid ester and a phospholipid, and a metalworking method using the composition and metalwork obtained by the metalworking method. The oil composition shows excellent lubricity and antirust property and is suitably used for metalworking of metallic materials such as cast iron, steel, stainless steel, and nonferrous metal (such as Al alloy and Mg alloy) by a method in which a very small amount of oil is supplied. | 2009-12-03 |
20090298731 | Method of Lubricating Food Processing Equipment and Related Food Grade, High Temperature Lubricants and Compositions - Methods of lubricating food processing equipment that include applying a food grade, high temperature lubricant composition to the food processing equipment are described. The composition includes a polyol polyester base oil that is a reaction product of at least one neopentyl polyhydric alcohol and at least one monocarboxylic acid. Also described are methods of preparing a food grade, high temperature composition comprising reacting at least one neopentyl polyhydric alcohol and at least one monocarboxylic acid. The composition may be a lubricant composition. Additionally, the invention provides a food grade, high temperature lubricant composition comprising a polyol polyester base oil that is a reaction product of at least one neopentyl polyhydric alcohol and at least one monocarboxylic acid. | 2009-12-03 |
20090298732 | GEAR OIL COMPOSITIONS, METHODS OF MAKING AND USING THEREOF - A gear oil composition is provided. The composition comprises a sufficient amount of an isomerized base oil in a base oil matrix comprising at least at least a polyalphaolefin for the gear oil composition to have for the gear oil composition to have an average volume change in a rubber seal between −10 and +10, a change in shore A hardness between −7 and +10 when tested with SRE NBR28 at 100° C., 168 hours per DIN53521 and DIN53505, a viscosity increase of less than 3% per US Steel S-200 oxidation stability test, a precipitation of less than 1% per US Steel S-200 oxidation stability test, and a Timken OK Load of greater than 60 lb. The isomerized base oil has consecutive numbers of carbon atoms and less than 10 wt % naphthenic carbon by n-d-M. In one embodiment, the sufficient amount of isomerized base oil ranges from 20 to 75 wt. % based on the total weight of the gear oil composition. | 2009-12-03 |
20090298733 | ACID CLEANING STRIPPER WITH VISUAL DOSAGE AND RINSING INDICATOR - The present invention relates to a liquid stripper comprising a strong acid, and a colored indicator capable of assuming different colors, in particular for non measurable pH (i.e. below 1), depending on the acid concentration and on the polarity of the stripping solution, as well as to its use. | 2009-12-03 |
20090298734 | PIPE UNBLOCKER VISUAL TEMPERATURE AND RINSING INDICATOR - The present invention relates to a liquid pipe unblocker comprising at least one strong acid, and a colored indicator capable of assuming different colors, depending on the acid concentration and on the polarity of the pipe unblocker solution. | 2009-12-03 |
20090298735 | Cleaning Compositions with Amphiphilic Graft Polymers Based on Polyalkylene Oxides and Vinyl Esters - Laundry detergent and cleaning compositions comprising amphiphilic graft polymers based on water-soluble polyalkylene oxides (A) as a graft base and side chains formed by polymerization of a vinyl ester component (B), said polymers having an average of ≦1 graft site per 50 alkylene oxide units and mean molar masses M | 2009-12-03 |
20090298736 | Cleaning Compositions For Glass Surfaces - Multi-armed silyl polyalkoxylates of the formula (I), (H-A) | 2009-12-03 |
20090298737 | Acidic Cleaning Composition Containing A Hydrophilizing Polymer - An acidic cleaning composition designed to clean hard surfaces and to prevent soil build-up comprising a hydrophilizing polymer, a surfactant, and an acid and to methods of using the composition to remove limescale and/or soapscum. | 2009-12-03 |
20090298738 | Biodegradable scale control composition for use in highly concentrated Alkaline hard surface detergents - An alkaline concentrated detergent composition for use in cleaning hard surfaces, medical instruments and other metal components (parts, tools, utensils, vessels, equipment) having superior cleaning efficacy at much lower alkali content than traditional alkaline cleaners and enhanced scale control properties even when diluted to about 1/40 ounce per gallon to about 1/10 ounce per gallon in potable water and even in exceptionally hard water. The inventive composition maintains its superior cleaning efficacy and scale control properties during use. | 2009-12-03 |
20090298739 | Surfactant Concentrate - The present relates to a surfactant concentrate comprising at least 75% of an essentially completely neutralized anionic sulphated surfactant and 5% to 25% carboxylic acid, of which 4% to 96% of the carboxylic acid is in its free acid form, the process for making it and a detergent composition containing it. | 2009-12-03 |
20090298740 | NOVEL NUCLEOTIDE SEQUENCES - The present invention relates to the field of cancer therapy. More specifically, the invention relates to use of certain nucleotide sequences for the treatment of cancer. | 2009-12-03 |
20090298741 | Trophic Factor Combinations for Nervous System Treatment - The present invention relates to a composition including an effective amount of at least one of an antimicrobial peptide and a substance having an antimicrobial peptide effect and an effective amount of a neurotrophin. The composition can also include an effective amount of at least one of a growth factor and a neuropeptide. The present invention also relates a method of treating an injury to a nervous system of an animal that includes the steps of identifying the injury to the nervous system and applying to the injury an effective amount of at least one of antimicrobial peptide and a substance having an antimicrobial peptide effect. The method can also include applying an effective amount of one or more trophic factors selected from the group consisting of a growth factor, a neurotrophin, and a neuropeptide to the injury. | 2009-12-03 |
20090298742 | PROCESS FOR MANUFACTURING LACTOSE - A process for forming crystalline lactose suitable for use in a pharmaceutical formulation comprises subjecting a solution comprising a plurality of nanosized lactose particles to conditions sufficient to cause crystallization to occur on the nanosized lactose particles such that a plurality of lactose particles are formed therefrom having a median diameter ranging from about 4 μm to about 20 μm. | 2009-12-03 |
20090298743 | HYDROPHOBIC COMPOSITIONS CONTAINING RECONSTITUTION ENHANCER - Disclosed are compositions comprising a hydrophobic active agent, a polymer and a reconstitution enhancing agent. Reconstitution of the lyophilized form of the compositions takes less time than in the absence of the enhancing agent. | 2009-12-03 |
20090298744 | HETEROCYCLIC COMPOUNDS AS ADENOSINE RECEPTOR ANTAGONIST - Compounds of the present disclosure are fused pyrimidine compounds of formula (I), its tautomers, polymorphs, stereoisomers, prodrugs, solvate or a pharmaceutically acceptable salts thereof, as Adenosine receptor antagonists. | 2009-12-03 |
20090298745 | Treatment of Diabetes with Glycogen Phosphorylase Inhibitors - The invention provides a method of treatment of diabetes, particularly type II diabetes, or a diabetes related condition, comprising night time dosing of an inhibitor of glycogen phosphorylase, optionally in combination another anti-diabetic therapy. | 2009-12-03 |
20090298746 | Pegylated hemoglobin and albumin and uses thereof - The present invention provides PEGylated hemoglobins and PEGylated albumins comprising polyethylene glycol (PEG) conjugated to hemoglobin or to albumin, wherein the PEG is a maleimide PEG, an alkylamide PEG, an iodoacetamide PEG, a p-nitro thio-phenyl PEG, a vinyl sulfone PEG, or a mixed disulfide PEG; and PEGylated albumins and PEGylated hemoglobins comprising polyethylene glycol (PEG) attached to a thiolated amino group of albumin or hemoglobin, wherein the amino group is thiolated using dithio sulfo succinimidyl propionate (DTSSP) or dithiosuccinimidyl propionate (DTSP) or dithiobispropionimidate. The invention also provides methods of preparing PEGylated hemoglobins and PEGylated albumins comprising a) reacting hemoglobin or albumin with a thiolating agent and with a PEGylating agent, and b) capping unPEGylated reactive thiols of hemoglobin or albumin with N-ethyl maleimide. | 2009-12-03 |
20090298747 | Methods and Compositions For Treatment of Nitric Oxide-Induced Clinical Conditions - The present invention provides compositions and methods for modulating cellular nitric oxide (NO) production and for treating a clinical condition associated therewith. | 2009-12-03 |
20090298748 | METHODS OF ADMINISTERING DALBAVANCIN FOR TREATMENT OF BACTERIAL INFECTIONS - The invention provides methods and compositions for treatment of bacterial infections. Methods of the invention include administration of dalbavancin for treatment of a bacterial infection, in particular a Gram-positive bacterial infection of skin and soft tissue. Dosing regimes include once weekly administration of dalbavancin, which often remains at therapeutic levels in the bloodstream for at least one week, providing prolonged therapeutic action against a bacterial infection. | 2009-12-03 |
20090298749 | DALBAVANCIN COMPOSITIONS FOR TREATMENT OF BACTERIAL INFECTIONS - The invention provides methods and compositions for treatment of bacterial infections. The composition may be a combination of factors, which include A | 2009-12-03 |
20090298750 | DAPTOMYCIN FOR THE TREATMENT OF BIOFILM AND CATHETER SALVAGE - Daptomycin can be used for biofilm treatment (particularly central venous catheter salvage for | 2009-12-03 |
20090298751 | Arylalkyl and Heteroarylalkyl Derivaties of Cyclosporine a for the Treatment and Prevention of Viral Infection - This invention provides compounds of general formula (T): (I) wherein A, B, R | 2009-12-03 |
20090298752 | APLIDINE TREATMENT OF CANCERS - Aplidine demonstrates considerable promise in phase (I) clinical trials for treatment of tumors, and various dosing regimes are given. Tumor reduction has been observed in several tumor types including renal carcinoma, colorectal cancer, lung carcinoid, medullary thyroid carcinomas and melanoma. It has also been found that aplidine has a role in inhibiting angiogenesis, complementing the anti-tumor activity. | 2009-12-03 |
20090298753 | METHODS FOR THE THERAPEUTIC USE OF CYCLOSPORINE COMPONENTS - Methods of treating humans or animals having various conditions are disclosed which include administering a therapeutically effective amount of a cyclosporine component to the human or animal, thereby treating the condition. Among the conditions treated are systemic lupus eryhematosis, multiple sclerosis, maloplabia of the skin, oral frictional hyperkeratosis, oral manifestations of autoimmune blistering disease, oral lichen planus, aphthous ulcers, nasal polyps, rhinosporiodosis, sinusitis, iritis, carcinoid lung, laryngitis and atrophic gastritis. | 2009-12-03 |
20090298754 | Hai-1 and hai-2 in cancer therapy - The invention relates to a novel therapeutic composition for treating cancer, and particularly prostrate and breast cancer, the composition comprises mixture of two hepatocyte growth factor activator inhibitors HAI-1 and HAI-2. | 2009-12-03 |
20090298756 | FUNCTIONS AND USES OF GPR39 GENE IN MAMMALIAN CENTRAL NERVOUS SYSTEM - The present invention provides mammalian GPR39 gene, its coded products, and the uses in regulating appetite and pain sensitivity. A pharmaceutical composition and a health product comprising GPR39 protein are also provided. The health product and the pharmaceutical composition for suppressing appetite or decreasing pain sensitivity comprise a safe and efficient amount of antagonists of mammalian GPR39 protein (for example, 0.01-99%) and a bromatologically or pharmaceutically acceptable carrier in a suitable amount (for example 1-99.99 wt %). | 2009-12-03 |
20090298757 | OXYNTOMODULIN ANALOGUES AND THEIR EFFECTS ON FEEDING BEHAVIOUR - Compounds of the invention are novel peptide analogues of oxyntomodulin (oxm) in which one or more amino acids of the oxm sequence have been changed. Changing amino acids 15-24 of oxm to either amino acids 968-977 of the α-latrotoxin peptide (and variations thereof) or amino acids 15-24 of exendin-4 (and variations thereof), or combinations of sequences from these sources, and/or changing amino acids 27-33 of oxm to amino acids 27-33 of exendin-4, and/or the addition of amino acids to the C-terminus of the peptide, results in a series of analogues of oxm that demonstrate the oxm like activity of reducing food intake, and with certain embodiments a greater ability to decrease food intake. | 2009-12-03 |
20090298758 | THYMOSIN BETA 4 DERIVATIVES AND USE THEREOF - The present invention relates to thymosin β4 (Tβ4) derivatives, Gly-Tβ4 and Ala-Tβ4. The present invention further relates to a pharmaceutical composition comprising the said Tβ4 derivatives. The present invention also relates to the use of said Tβ4 derivatives in manufacture of a medicament for treatment of skin lesion, heart injury, corneal lesion and/or coronary heart disease. The present invention further relates to a method of treatment for skin lesion, heart injury, corneal lesion and/or coronary heart disease by using the said Tβ4 derivatives. | 2009-12-03 |
20090298759 | C-Reactive Protein and Its Use to Treat Systemic Lupus Erythematosus and Related Conditions - The present invention relates to the use of C-reactive protein, its mutants, metabolites and polypeptides and related compounds thereof for the treatment of various disease states and conditions associated with systemic lupus erythematosus (SLE), including lupus of the skin (discoid), systemic lupus of the joints, lungs and kidneys, hematological conditions including hemolytic anemia and low lymphocyte counts, lymphadenopathy and CNS effects including memory loss, seizures and psychosis, among numerous others as otherwise disclosed herein, in another aspect of the invention, the reduction in the likelihood that a patient who is at risk for an outbreak of a disease state or condition with systemic lupus erythematosus will have an outbreak is an additional aspect of the present invention. | 2009-12-03 |
20090298760 | Modified Coagulation Factor VIIa With Extended Half-Life - The present invention relates to the fields of Factor VII (FVII) and Factor VIIa (FVIIa) albumin linked polypeptides. More specifically, the invention relates to cDNA sequences coding for human Factor VII and Factor VIIa and derivatives genetically fused to a cDNA coding for human serum albumin which may be linked by oligonucleotides which code for intervening peptidic linkers such encoded derivatives exhibiting improved stability and extended functional plasma half-life, recombinant expression vectors containing such cDNA sequences, host cells transformed with such recombinant expression vectors, recombinant polypeptides and derivatives which do have biological activities of the unmodified wild type protein but having improved stability and prolonged shelf-life and processes for the manufacture of such recombinant proteins and their derivatives. The invention also covers a transfer vector for use in human gene therapy, which comprises such modified DNA sequences. | 2009-12-03 |
20090298761 | Methods of treating cartilage defects using a soluble morphogenic protein complex - The present invention provides methods of repairing and regenerating cartilage tissue using a soluble morphogenic protein complex comprising (a) a morphogenic protein; and (b) a morphogenic protein pro region isolated from a morphogenic protein, or a conservative substitution variant or a fragment of said pro region, wherein said pro region or variant or fragment is noncovalently linked to the morphogenic protein, and wherein said complex is more soluble in an aqueous solvent than said morphogenic protein alone. | 2009-12-03 |
20090298762 | CONJUGATES OF BIOLOGICALLY ACTIVE PROTEINS HAVING A MODIFIED IN VIVO HALF-LIFE - Disclosed are biologically active protein conjugates that comprise a biologically active polypeptide coupled via a peptide bond to a polypeptide comprising from 2 to about 500 units of a repeating peptide motif, wherein the biologically active protein conjugate exhibits a modified plasma half-life compared to the intrinsic half-life of the unconjugated biologically active polypeptide or protein. Also disclosed are methods of making and using the conjugated proteins, as well as methods for determining whether a given conjugate exhibits a modified half life relative to the intrinsic half life of the unconjugated polypeptide. | 2009-12-03 |
20090298763 | POLYNUCLEOTIDES AND POLYPEPTIDE SEQUENCES INVOLVED IN THE PROCESS OF BONE REMODELING - This invention relates, in part, to unique and newly identified genetic polynucleotides involved in the process of bone remodeling, variants and derivatives of the polynucleotides and corresponding polypeptides, uses of the polynucleotides, polypeptides, variants and derivatives, and methods and compositions for the amelioration of symptoms caused by bone remodeling disorders. Disclosed in particular are the isolation and identification of polynucleotides polypeptides variants and derivatives involved in osteoclast activity, validation of the identified polynucleotides for their potential as therapeutic targets and use of the polynucleotides, polypeptides, variants and derivatives for the amelioration of disease states and research purposes. | 2009-12-03 |
20090298764 | GENE AND PATHWAY AND THEIR USE IN METHODS AND COMPOSITIONS FOR PREDICTING ONSET OR PROGRESSION OF AUTOIMMUNE AND/OR AUTOINFLAMMATORY DISEASES - Embodiments of the present invention concern methods, compositions and uses thereof, relating to at least one of vitiligo, or vitiligo-associated autoimmune/autoinflammatory disease (VAAAD). In particular embodiments, genetic variations in the NALP1 gene are of use to detect, diagnose, predict the risk of or treat at least one of vitiligo or VAAAD. In more particular embodiments, the presence of genetic variations such as single-nucleotide polymorphisms (SNPs) in NALP1 genetic region are of use to detect, diagnose or predict the risk of VAAAD. In other embodiments, inhibitors targeted to NALP1, caspase-1 or caspase-5, ASC (PYCARD), interleukin-1β, interleukin-1β receptor, or interleukin 18 may be administered to a subject to treat VAAAD. | 2009-12-03 |
20090298765 | Metastin derivatives and use thereof - The invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, etc.). By modifying the constituent amino acids of metastin with specific modifying groups, metastin derivatives having more improved blood stability, etc. than native metastin and showing excellent cancer metastasis suppressing activity or cancer growth suppressing activity have been found. Furthermore, it has been found that these metastin derivatives exhibit effects of suppressing gonadotropic hormone secretion, suppressing sex hormone secretion, etc., which are wholly different from the effects heretofore known. | 2009-12-03 |
20090298766 | DETECTION AND TREATMENT OF CANCERS - The present invention relates to methods and compositions for the detection and treatment of melanoma and skin cancers. More particularly, the invention discloses that BCSC-1 expression is altered in melanoma and skin cancer cells, allowing the design of effective detection methods and kits for such conditions. The invention also shows that restoring or increasing expression of BCSC-1 in melanoma and skin cancer cells suppresses tumorigenicity and represents a novel and effective approach for the treatment of melanoma and skin cancers. The invention may be used to detect the presence, stage or type of melanoma and skin cancers, as well as any predisposition thereto. The invention may be used in any mammalian subject, particularly human subjects. | 2009-12-03 |
20090298767 | FORMULATION COMPRISING WHEY PROTEIN AND HYDROLYSATES FOR IMPROVING MUSCLE RECOVERY - The present invention relates to a formulation comprising whey protein or a hydrolysate of whey protein, which formulation is capable of inhibiting the expression of TNFα in lipopolysaccharide-stimulated macrophages in vitro. Also provided are uses of the formulation for attenuating a reduction in muscle function which results from muscle damage and/or for enhancing recovery from muscle damage and/or for enhancing the force generating capacity of muscle and methods of making the formulation. | 2009-12-03 |
20090298768 | STABLE LIQUID FORMULATION OF HUMAN GROWTH HORMONE - Disclosed herein is a stable liquid formulation comprising human growth hormone; L-lysine, L-arginine or polyethylene glycol 300; and poly(oxyethylene) poly(oxypropylene) copolymer, polyethylene glycol-15 polyoxystearate or polyethylene glycol-35 castor oil. | 2009-12-03 |
20090298769 | COMPOUNDS AND METHODS OF MODULATING ANGIOGENESIS - A method of modulating angiogenesis in a tissue comprises administering to the tissue a therapeutically effective amount of an agent that modulates complex formation of α | 2009-12-03 |
20090298770 | MAMMALIAN RELAXIN RECEPTORS - High affinity relaxin receptors, polypeptide compositions related thereto, as well as nucleotide compositions encoding the same, are provided. These proteins, herein termed LGR7 and LGR8, are orphan leucine-repeat-containing, G protein-coupled receptors. These receptors have a wide and a unique tissue expression pattern. The receptors, particularly soluble fragments thereof, are useful as therapeutic agents capable of inhibiting the action of relaxin and InsL3. The receptors and fragments thereof also find use in the screening and design of relaxin agonists and antagonists. Conditions treatable with relaxin agonists or antagonists include prevention or induction of labor, treatment of endometriosis, treatment of skin conditions such as scleroderma that require collagen or extracellular matrix remodelling. Additionally, relaxin has been implicated in the dilation of blood vessels' smooth muscle cells directly and through release of nitric oxide and atrial natriuretic peptide. Relaxin has also been used in the treatment of severe chronic pain, particularly pain arising from stretching, swelling, or dislocation of tissues. | 2009-12-03 |
20090298771 | USE OF SECRETED PROTEIN PRODUCTS FOR PREVENTING AND TREATING PANCREATIC DISEASES AND/OR OBESITY AND/OR METABOLIC SYNDROME - This invention relates to the use of secreted SF01-SF13 proteins, to the use of polynucleotides encoding these, and to the use of effectors/modulators thereof in the diagnosis, study, prevention, and treatment of pancreatic diseases (e.g. diabetes mellitus), obesity and/or metabolic syndrome and to the use in regeneration of tissues such as pancreatic tissues and others. | 2009-12-03 |
20090298772 | THERAPEUTICS TO INHIBIT MLL-MENIN INTERACTION FOR TREATING LEUKEMIA - Cell permeable peptides derived from MLL that block the interaction of MLL with menin for the treatment of acute mycloid and acute lymphoid leukemia are disclosed. Small molecules interfere with the interaction of MLL with any of its binding partners. | 2009-12-03 |
20090298773 | METHODS OF PRODUCING FUNCTIONAL MISO - According to the present invention a miso with good flavor and a processed food containing the miso are provided, wherein the miso and the food are expected to have an repressing effect on an increase in blood pressure or hypotensive effect by continually taking the miso or food for routinely dietary habit. The present invention also provides a method of producing a miso, wherein peptides with ACE inhibitory activity are effectively produced in the miso without lowering the quality in flavor of miso. In an embodiment of the present invention, animal milk is added at a content of 10% during a mixing step, or a fermentation and ripening step. | 2009-12-03 |
20090298774 | Bifunctional Molecules for Inhibiting HIV Entry - Disclosed herein are bifunctional molecules which inhibit HIV entry into the target cell. Also disclosed are novel anti-HIV therapeutics for treatment of patients infected by HIV, including non-B and multi-drug resistant strains. | 2009-12-03 |
20090298775 | METHOD OF MEASURING NEPRILYSIN ACTIVITY - The present invention provides a method of measuring the activity of neprilysin, etc. More specifically, the present invention provides a method of measuring the activity of neprilysin in nerve cells; a method of screening a protein, a peptide or a compound enhancing the activity or expression of neprilysin in nerve cells by measuring the activity of neprilysin; a method of enhancing the activity or expression of neprilysin; and so on. Thus, the compound enhancing the activity and/or expression of neprilysin, which is obtained by the screening method characterized by using the method of measuring the activity of neprilysin in accordance with the present invention, is useful as a preventive and/or therapeutic agent for Alzheimer's disease. The method of measuring the activity of the present invention can be used for presymptomatic diagnosis of Alzheimer's disease. | 2009-12-03 |
20090298776 | SPINAL FUSION METHODS AND DEVICES - Methods, devices and compositions for fusing adjacent vertebrae, and otherwise localizing bone growth, are provided. In one form of the invention, a method for fusing adjacent vertebrae includes preparing a disc space for receipt of an intervertebral disc implant in an interwertebral disc space between adjacent vertebrae, inserting the implant into the intervertebral disc space and providing an osteoinductive composition that includes an osteoinductive factor in a pharmaceutically acceptable carrier. The carrier is advantageously substantially impermeable to efflux of the osteoinductive factor and is released as the carrier is resorbed or biodegraded. Preferred carriers include a hardened, resorbable carrier, such as a calcium phosphate cement that retains at least about 50% of the osteoinductive factors greater than about 2 days. Preferred osteoinductive factors are growth factors and include bone morphogenctic proteins and LIM mineralization proteins. In alternative forms of the invention, the method may be performed without utilization of a load-bearing spinal implant by disposing the osteoinductive composition in the disc space. The method is advantageously performed on lumbar vertebrae by a posterior approach. Intervertebral fusion devices and methods for their preparation are also provided. | 2009-12-03 |