48th week of 2014 patent applcation highlights part 53 |
Patent application number | Title | Published |
20140350234 | Nucleosides and Oligonucleotides for Studies on Reversal of Cytotoxic and Mutagenic Damage of DNA and as Diagnostics Tools - The present invention is directed to n-alkylated synthetic nucleosides of high regiospecific purity and oligonucleotides that can be utilized for studies on reversal of cytotoxic and mutagenic DNA damage, and as diagnostic tools. | 2014-11-27 |
20140350235 | IN SITU OLIGONUCLEOTIDE SYNTHESIS ON A PARAMAGNETIC SUPPORT - A novel method for attaching oligonucleotides to a paramagnetic solid support is disclosed. Conventional methods of attachment require that oligonucleotides be pre-synthesized with specific end modifications, which is laborious and expensive. Instead, we attached oligonucleotides to paramagnetic beads by direct synthesis of the oligonucleotides on the surface of the beads. An external magnet was used to hold the paramagnetic beads in place during solid-phase synthesis. A magnetic force was applied directly to the beads to prevent their loss, in particular, during reagent purge-to-waste steps that involved high-pressure drain or vacuum. This method can be adapted for use in any laboratory working with conventional synthesis automation, and can be employed, for example, with single columns and multi-well titer plates. | 2014-11-27 |
20140350236 | METHOD OF PREPARING CATIONIC STARCH USING ULTRAHIGH PRESSURE - Disclosed is a method of preparing cationic starch. The method includes preparing a starch suspension containing a cationization agent; performing ultrahigh pressure treatment on the starch suspension; and obtaining cationic starch from the starch suspension subjected to ultrahigh pressure treatment. | 2014-11-27 |
20140350237 | PHOTO-CROSSLINKED GELLAN GUM-BASED HYDROGELS: METHODS AND USES THEREOF - This invention refers to photo-crosslinked hydrogel materials based in gellan gum suitable for tissue engineering and regenerative medicine applications or as drug delivery systems. | 2014-11-27 |
20140350238 | COMPOSITION OF NOVEL CARBOHYDRATE DRUG FOR TREATMENT OF HUMAN DISEASES - Aspects of the invention provide compositions for use in the treatment galectin-dependent diseases. In particular, compositions comprising a selectively depolymerized, branched galactoarabino-rhamnogalacturonate whose backbone is predominantly comprised of 1,4-linked galacturonic acid (GalA) moieties, with a lesser backbone composition of alternating 1,4-linked GalA and 1,2-linked rhamnose (Rha), which in-turn is linked to any number of side chains, including predominantly 1,4-b-D-galactose (Gal) and 1,5-a-L-arabinose (Ara) residues. | 2014-11-27 |
20140350239 | PHARMACEUTICAL COMPOSITION FOR RELIEVING PAIN - The present invention relates to a pharmaceutical composition for relieving pain in a joint disease, including a hyaluronic acid and a pharmaceutically acceptable carrier, in which the hyaluronic acid is cross-linked by cyclizing a double bond in the moiety of a cinnamic acid in a partially amidated hyaluronic acid represented by Formula (1): [Ar—CH═CH—COO—(CH | 2014-11-27 |
20140350240 | PROCESS FOR PREPARING CEFTAROLINE SALTS OR HYDRATES THEREOF - The present invention relates to a process for the preparation of ceftaroline salts or hydrates thereof. | 2014-11-27 |
20140350241 | PHOSPHINATE RUTHENIUM COMPLEXES - Provided herein are ruthenium complexes of Formula I, and processes of preparation thereof. Also provided are methods of their use as a metathesis catalyst. | 2014-11-27 |
20140350242 | PSEUDOROTAXANES, ROTAXANES AND CATENANES FORMED BY METAL IONS TEMPLATING - A pseudorotaxane, a rotaxane and a catenane are provided. The pseudorotaxane includes at least a macrocyclic host molecule, a guest molecule, and a metal ion. The host molecule contains at least a binding unit and an aromatic linking spacer. The guest molecule has at least a recognition unit. The metal ion is used to template the threading of the guest molecule through the macrocycle host molecule by coordinating to a binding pocket formed from the binding unit of the macrocycle and the recognition moiety of the guest molecule. Rotaxanes or catenanes can be synthesized from the pseudorotaxane complexes, with or without the metal template ion in their molecular structures. | 2014-11-27 |
20140350243 | MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES - The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices. | 2014-11-27 |
20140350244 | FUSED PYRIDINE, PYRIMIDINE AND TRIAZINE COMPOUNDS AS CELL CYCLE INHIBITORS - Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are fused pyridine, pyrimide and triazine derivatives. | 2014-11-27 |
20140350245 | TETRAHYDROPYRROLOTHIAZINE COMPOUNDS - The present invention provides a compound of Formula I: | 2014-11-27 |
20140350246 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING THE SAME - The present invention relates to 7-membered nitrogen-containing heterocyclic compounds and methods of making the same. Using a novel aza-[4+3] cycloaddition reaction, the 7-membered heterocyclic compounds are synthesized by reacting a first reactant and a second reactant. Exemplary first reactants and second reactants include α-halohydroxamates and dienes, respectively. | 2014-11-27 |
20140350247 | ARYL-AMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME AS A HOLE TRANSPORT MATERIAL - An aryl amine derivative and an organic electroluminescent device using the aryl amine derivative as a hole transport material, the aryl amine derivative being represented by the following Chemical Formula 1. | 2014-11-27 |
20140350248 | CHEMICAL ENTITIES AND THERAPEUTIC USES THEREOF - Certain chemical entities that modulate PI3 kinase activity, and chemical entities, pharmaceutical compositions, and methods of treatments of diseases and conditions associated with PB kinase activity are described. | 2014-11-27 |
20140350249 | THERAPEUTIC AGENT FOR CEREBRAL INFARCTION - The present invention provides a novel therapeutic drug for cerebral infarction, which contains a piperazine compound as an active ingredient. The compound of the present invention can be provided as a novel therapeutic drug for cerebral infarction having an effect of suppressing brain injury volume or improving neurological deficit, since it suppresses production of plural inflammatory cytokines and chemokines present in the brain such as TNF-α, IL-1β, IL-6 and MCP-1 and the like. | 2014-11-27 |
20140350250 | THERAPEUTIC AGENT FOR CEREBRAL INFARCTION - The present invention provides a novel therapeutic drug for cerebral infarction, which contains a piperazine compound as an active ingredient. The compound of the present invention can be provided as a novel therapeutic drug for cerebral infarction having an effect of suppressing brain injury volume or improving neurological deficit, since it suppresses production of plural inflammatory cytokines and chemokines present in the brain such as TNF-α, IL-1β, IL-6 and MCP-1 and the like. | 2014-11-27 |
20140350251 | HERBICIDAL PYRIMIDINES - Compounds of Formula I, and their N-oxides and agriculturally suitable salts, are disclosed which are useful for controlling undesired vegetation | 2014-11-27 |
20140350252 | PROCESS FOR THE PREPARATION OF VORICONAZOLE AND INTERMEDIATES THEREOF - The present invention relates to an improved stereoselective process for the preparation of (2R,3S/2S,3R)-3-(4-chloro-5-fluoropyrimidin-6-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol intermediate compound. This intermediate compound is further used to prepare voriconazole—a triazole antifungal agent. | 2014-11-27 |
20140350253 | ASYMMETRIC ELECTROPHILIC FLUORINATION USING AN ANIONIC CHIRAL PHASE-TRANSFER CATALYST - The discovery of distinct modes of asymmetric catalysis has the potential to rapidly advance chemists' ability to build enantioenriched molecules. As an example, the use of chiral cation salts as phase-transfer catalysts for anionic reagents has enabled a vast set of enantioselective transformations. A largely overlooked analogous mechanism wherein a chiral anionic catalyst brings a cationic species into solution is itself a powerful method. The concept is broadly applicable to a number of different reaction pathways, including to the enantioselective fluorocyclization of olefins, and dearomatization of aromatic systems with a cationic electrophile-transferring (e.g., fluorinating) agent and a chiral phosphate catalyst. The reactions proceed in high yield and stereoselectivity. The compounds and methods of the invention are of particular value, especially considering the scarcity of alternative approaches. | 2014-11-27 |
20140350254 | Heterocyclic Compounds for the Treatment of Neurological and Psychological Disorders - Lactam compounds of Formula I and their use for the treatment of neurological and psychiatric disorders including schizophrenia, bipolar disorder, anxiety disorder and insomnia is disclosed. | 2014-11-27 |
20140350255 | PROCESS FOR THE PREPARATION OF VILAZODONE OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS - The present invention relates to a process for the preparation of vilazodone or its pharmaceutically acceptable salts. The present invention further provides a crystalline form of vilazodone free base. | 2014-11-27 |
20140350256 | IRON AND MANGANESE COMPLEXES COMPRISING HEXADENTATE MONOCARBOXYLATO-CONTAINING LIGANDS AND THEIR USE FOR THE CATALYSIS OF OXIDATION REACTIONS - The present invention relates to iron and manganese complexes based on hexadentate ligand systems containing one carboxylato donor and five nitrogen donor atoms and to their use in methods for the catalysis of the oxidation of organic substrates. The manganese complexes of the invention also may be used as (pro)-catalysts in methods for the catalysis of water. | 2014-11-27 |
20140350257 | Process for the Preparation of a DPP-IV Inhibitor - The present invention is concerned with an improved process for the preparation of pyrido[2,1-a]isoquinoline derivatives of formula I | 2014-11-27 |
20140350258 | Alpha-Hydrogen Substituted Nitroxyls And Derivatives Thereof As Catalysts - Novel alpha-hydrogen substituted nitroxyl compounds and their corresponding oxidized (oxoammonium cations) and reduced (hydroxylamine) forms, and the use of such compounds, inter alia, for oxidation of primary and secondary alcohols to aldehydes and ketones, respectively; resolution of racemic alcohols; desymmetrization of meso-alcohol; as radicals and spin trapping reagents; and as polymerization agents. Processes for preparing the novel nitroxyl/oxoammonium/hydroxylamine compounds from the corresponding amines, and certain novel amine derivatives and their uses. The compounds and amine precursors are useful as ligands for transition metals and as organocatalysts in e.g., aldol reactions. | 2014-11-27 |
20140350259 | PROCESS FOR THE PREPARATION OF 2-PHENYL-[1,2,4]TRIAZOLO[1,5-A]PYRIDINE DERIVATIVES - The invention relates to a novel process for the preparation of 2-phenyl-[1,2,4]triazolo[1,5-a]pyridine derivatives of formula I or of a salt thereof | 2014-11-27 |
20140350260 | HETEROCYCLIC COMPOUND AND USE THEREOF - The present invention provides a heterocycle derivative having a superior amyloid β production inhibitory activity and/or a superior γ-secretase modulation activity, and use thereof. A compound represented by the formula (I): | 2014-11-27 |
20140350261 | METHOD FOR CATALYTIC ASYMMETRIC SYNTHESIS OF OPTICALLY ACTIVE ISOXAZOLINE COMPOUND, AND OPTICALLY ACTIVE ISOXAZOLINE COMPOUND - There is provided a method for catalytic asymmetric synthesis of optically active isoxazoline compound and an optically active isoxazoline compound. A method for catalytic asymmetric synthesis of optically active isoxazoline compound of a formula (6) including reacting an α,β-unsaturated carbonyl compound of a formula (1) and a hydroxylamine in a solvent in the presence of a base by adding a chiral phase transfer catalyst. An optically active isoxazoline compound of a formula (13) that can be synthesized by the method. | 2014-11-27 |
20140350262 | Reactivators Of Organophosphorous Inhibited Acetylcholinesterase - The present invention relates to organophosphate-inhibited acetylcholinesterase (AChE) reactivators with central nervous system (CNS) bioavailability and their associated methods of preparation including their use for treatment of exposure to AChE inhibitors such as an organophosphate (OP) insecticides and nerve agents. | 2014-11-27 |
20140350263 | RAPID FLUORESCENCE TAGGING OF GLYCANS AND OTHER BIOMOLECULES WITH ENHANCED MS SIGNALS - Reagents comprising MS active, fluorescent molecules with an activated functionality for reaction with amines useful in tagging biomolecules such as N-glycans and uses thereof are taught and described. | 2014-11-27 |
20140350264 | Process for the Preparation of (5-Fluoro-2-methyl-3-quinolin-2-ylmethyl-indol-1-yl)-Acetic Acid Esters - The invention relates to a process for the preparation of a compound of formula (I) wherein R | 2014-11-27 |
20140350265 | Method for producing compounds comprising nitrile functions - The present invention concerns the production of compounds comprising nitrite functions and cyclic imide compounds. More specifically, the invention relates to the production of compounds comprising nitrile functions from compounds comprising carboxylic functions, advantageously of natural and renewable origin, and from methyl-2 glutaronitrile (MGN) or a mixture N of dinitriles comprising methyl-2 glutaronitrile (MGN), ethyl-2 succinonitrile (ESN) and adiponitrile (AdN). | 2014-11-27 |
20140350266 | High-Performing Stable Green Replacements for Ammonium Perchlorate - A highly energetic, high-oxygen carrier suitable as high-performing green replacement for ammonium perchlorate includes halogen-free ionic salts consisting of fuel cations and over-oxidized anions containing multiple nitro- or nitromethyl-substituted azolyl ligands. The over-oxidized anions include a central atom selected from the group consisting of boron, aluminum, or gallium. Characteristically, the carrier has sufficient amounts of oxygen for complete or near complete combustion of the over-oxidized anions, the fuel cations, metal additives and binders. | 2014-11-27 |
20140350267 | PROCESS FOR THE PREPARATION OF N-SUBSTITUTED PYRAZOLE COMPOUNDS - A process for the preparation of a compound of formula I: | 2014-11-27 |
20140350268 | CHIRAL IMIDODIPHOSPHATES AND DERIVATIVES THEREOF - The invention relates to chiral imidodiphosphates and derivatives thereof having the general formula I, | 2014-11-27 |
20140350269 | Acetals Esters Produced from Purified Glycerin for Use and Application as Emollients, Lubricants, Plasticizers, Solvents, Coalescents, Humectant, Polymerization Monomers, Additives to Biofuels - It refers to a new group of acetal monoesters and diesters which have in its structure the ester function and cyclic ethers that give these products excellent properties as solvency, plasticity in polymers, solubility in polar and nonpolar means, spreadability, wetting, low volatility, non-toxicity and biodegradability. These properties make these products excellent candidates as solvents in formulations of pesticides, agricultural herbicides, for the paint and leather industry in domestic or industrial hygiene formulations; as plasticizers for polymers such as polyvinyl chloride, nitrocellulose, cellulose, acrylics, polyvinyl vinyl and its copolymers; as lubricants in industrial formulations, textile industry; as emollients agents which donate oiliness for the cosmetic industry; as wetting agents that are commonly used, and as biodiesel additives to reduce the freezing point and to improve its combustion. | 2014-11-27 |
20140350270 | Crystalline Darunavir - The present invention relates to a non-solvated crystalline Darunavir, process for its preparation and pharmaceutical composition comprising it. The present invention also relates to a process for the preparation of amorphous Darunavir from a non-solvated crystalline Darunavir. | 2014-11-27 |
20140350271 | PROCESS FOR CHEMICAL CONVERSION OF CELLULOSE ISOLATED FROM AROMATIC SPENT BIOMASS TO HYDROXY METHYL FURFURAL - The present invention relates to a process for chemical conversion of cellulose isolated from aromatic spent biomass to hydroxymethyl furfural using an eco-friendly and economical liquids system with recoverable and reusable solid Indion catalysts and zeolite-phosphomolybdic acid hybrid catalysts. The present invention further relates to the preparation of an effective hybrid catalyst i.e. zeolite-phosphomolybdic acid catalyst for synthesis of HMF. The selectivity and yield of HMF is nearly doubled in zeolite-phosphomolybdic acid hybrid catalyst compared to the individual catalysts (zeolite or phosphomolybdic acid) or combination of catalysts viz. zeolite and phosphomolybdic acid. | 2014-11-27 |
20140350272 | CRYSTALLINE FORMS OF DIMETHOXY DOCETAXEL AND METHODS FOR PREPARING THE SAME - The invention relates to anhydrides, solvates and ethanol hetero-solvates and hydrates of dimethoxy docetaxel or (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenyl-propionate of 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1-hydroxy-7β, 10β-dimethoxy-9-oxo-tax-11-ene-13α-yle, and to the preparation thereof. | 2014-11-27 |
20140350273 | PEDIATRIC USES OF CABAZITAXEL - The present invention relates to the compound of formula (I): | 2014-11-27 |
20140350274 | METHODS FOR ASYMMETRIC E POXIDATION USING FLOW REACTORS - Embodiments of the present disclosure relate to asymmetric epoxidation of olefinic alcohols, using a chiral alcohol chelated titanium catalyst and an organic peroxide performed in a microreactor flow reactor system that can comprise multiple microreactor modules. Molecular sieves can be used to remove any adventitious water in the reagent feed solutions and ensure an anhydrous reaction solution. The use of a microreactor flow reactor allows for the epoxidation reaction to be run at elevated temperatures of at least 20, 30, or even 50° C., which dramatically accelerates the reaction, but without a large drop in enantioselectivity. The reaction can therefore be performed with short reaction times resulting in a high throughput. | 2014-11-27 |
20140350275 | MIXED-VALENT TRANSITION METAL-PHOSPHORANIMIDE CATALYSTS - Phosphoranimide-metal catalysts are disclosed. The catalysts comprise first row transition metals such as nickel, cobalt or iron. The hydrocarbon-soluble catalysts have a metal to anionic phosphoranimide ratio of 1:1, and have no inactive bulk phase and no dative ancillary ligands. The electronic state of the clusters can be adjusted to optimize catalytic activity for a range of commercially important reductive transformations, including hydrodesulfurization. A method of synthesis of these catalysts by anionic metathesis of a halide substituted precursor followed by oxidation is also disclosed. | 2014-11-27 |
20140350276 | Phenolytic Kinetic Resolution of Azido and Alkoxy Epoxides - Disclosed herein is a single step catalytic process for the production of enantiomerically pure α-Aryloxy-α′-Azido/Alkoxy alcohols of formula (A). The invention, in particular discloses phenolytic kinetic resolution of racemic anti and syn azido/alkoxy epoxides to generate two stereocentres of high optical purities of formula (A). | 2014-11-27 |
20140350277 | Hydrolysable Silanes - This invention relates to hydrolysable silanes useful in the modification of elastomers, and as coupling agents for diene elastomer compositions containing a filler. In particular the invention relates to novel hydrolysable silanes containing a tertiary amine group and an ether or thioether linkage. | 2014-11-27 |
20140350278 | Polymerizable Hybrid Polysiloxanes and Preparation - The present invention relates to a process of making a polymerizable hybrid polysiloxane or a polymerizable hybrid siloxane. The process includes reacting an organopolysiloxane or organosiloxane having an average of at least 3 silicon hydride (SiH) groups per molecule, a polyoxyethylene, and a catalyst. The process also optionally includes adding a stabilizer, a catalytic inhibitor, a solvent, and an unsaturated reactant selected from substituted and unsubstituted unsaturated organic compounds. | 2014-11-27 |
20140350279 | METHOD FOR PREPARING METHYLCHLOROSILANES - The invention relates to a method for the direct synthesis of methylchlorosilanes by reacting chloromethane with a contact mass containing silicon, copper catalyst and at least 120 ppm by weight of manganese. | 2014-11-27 |
20140350280 | EXTRACTION SOLVENT CONTROL FOR REDUCING STABLE EMULSIONS - Disclosed herein are methods for recovering diphosphite-containing compounds from mixtures comprising organic mononitriles and organic dinitriles, using liquid-liquid extraction. Also disclosed are treatments to enhance extractability of the diphosphite-containing compounds. | 2014-11-27 |
20140350281 | PROCESS FOR MAKING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR - The invention provides a process for the preparation of a compound of Formula 1, | 2014-11-27 |
20140350282 | PRE CALCINATION ADDITIVES FOR MIXED METAL OXIDE AMMOXIDATION CATALYSTS - A process for preparation of catalysts for the production of acrylonitrile, acetonitrile and hydrogen cyanide comprising contacting at an elevated temperature, propylene, ammonia and oxygen in the vapor phase in the presence of a catalyst, said catalyst comprising a complex of metal oxides wherein a heat-decomposable nitrogen containing compound is added during the process for the preparation of the catalyst. | 2014-11-27 |
20140350283 | Compounds and Methods for Preparing Substituted 3-(1-amino-2-methylpentane-3-yl)phenyl Compounds - Compounds and methods for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds from an isomerically pure starting material are described. In particular, methods of preparing a 3-(1-(dimethylamino)-2-methylpentane-3-yl)phenol as a substantially optically pure (R,R) stereoisomer are described. Using a method of the present invention, only the (R,R) and (S,S) stereoisomers of the target compound are produced, increasing the yield and stereoselectivity of the desired (R,R) stereoisomer. | 2014-11-27 |
20140350284 | STEREOSELECTIVE SYNTHESIS OF METYROSINE - Provided herein are compositions including diastereomers in substantially diastereomerically pure form and enantiomers in substantially enantiomerically pure form, and processes for preparing them and converting them to metyrosine. | 2014-11-27 |
20140350285 | NOVEL POLYMORPHS OF N-[2-AMINO-4-(4-FLUOROBENZYLAMINO)-PHENYL] CARBAMIC ACID ETHYL ESTER AND PROCESSES THEREOF - The present invention relates to novel polymorphs of N-[2-amino-4-(4-fluorobenzylamino)-phenyl]carbamic acid ethyl ester, processes for preparing them, and pharmaceutical composition comprising them. In one aspect, the present invention relates to a novel crystalline polymorph of retigabine designated as crystalline Form I, characterized by XRPD having characteristic peaks at about 4.87, 5.04, 7.03, 9.74, 10.02, 11.6, 18.03, 19.9 and 28.5±0.2 degrees two-theta, which is substantially same as depicted in FIG. | 2014-11-27 |
20140350286 | Method for Making Two-Phase Solution of which Phase State Changes as aResult of Temperature Conversion React, and Apparatus for Implementing This - A method for making a number (N) of samples react under the same reaction conditions, wherein the samples have a solution where the phase state of a reaction solvent changes in a reversible manner between a two-phase solution state and a uniform solution state when the temperature fluctuates over or under a certain constant temperature, and the processes are carried out sequentially in the following steps: (A) the constant container heating step of heating a number of reaction containers simultaneously and maintaining the reaction containers at a predetermined temperature; (B) the sample heating step of putting a sample in each heated reaction container and of maintaining a two-phase solution at a predetermined temperature; (C) the reaction step of stirring the sample that has been heated to the predetermined temperature so as to gain a uniform solution, which is maintained for a predetermined period of time; (D) the cooling step of cooling the uniform solution without cooling the reaction container after the predetermined period of time has passed so as to gain a two-phase solution within the reaction container. | 2014-11-27 |
20140350287 | NEW PROCESS FOR THE PREPARATION OF 2,4,5-TRIFLUOROPHENYLACETIC ACID - The present invention relates to a new process for the preparation of 2,4,5-trifluorophenylacetic acid and salts thereof by means of new synthetic intermediates. | 2014-11-27 |
20140350288 | SYNTHESIS OF GALANAL COMPOUNDS AND ANALOGUES THEREOF - The present disclosure provides methods of preparing glucagon-like peptide-1 (GLP-1) receptor modulators, such as compounds of Formula (II) or (VI), or intermediates thereof. The compounds that may be prepared by the described methods are useful for regulating blood glucose levels and/or treating a disease mediated by a GLP-1 receptor (e.g., diabetes). | 2014-11-27 |
20140350289 | NEW ACID CHLORIDE - The present invention relates to new organic compounds, to their synthesis as well as to their use in organic synthesis, especially in processes forming intermediates (building blocks) for the synthesis of vitamin A or β-carotene or other carotenoids. | 2014-11-27 |
20140350290 | LIGHT-COLORED METAL WORKING ADDITIVES - A composition having a compound having the structure: | 2014-11-27 |
20140350291 | PROCESS FOR RECOVERING NOBLE PRODUCTS IN A PROCESS FOR PRODUCING DIALKYLAMINOALKYL (METH) ACRYLATES - The invention relates to a process for recovery of noble products from heavy (meth)acrylic fractions generated during production of (meth)acrylic esters by transesterification, the heavy fractions comprising at least noble products and Michael adducts, the process comprising the steps of: (i) adding at least one antifouling agent and optionally a viscosity-reducing compound to the heavy fractions; (ii) submitting the mixture to temperature and distillation conditions sufficient to crack the Michael adducts into their components; and (iii) recovering the noble products in the form of a stream of distillate, and of a final residue that is sufficiently fluid to be transported by pump. | 2014-11-27 |
20140350292 | SYNTHESIS OF DIESEL FUEL BLENDSTOCK FROM CARBOHYDRATES - Carbohydrates as derived from plant biomass can be converted into mono-alcohols, diols, and/or bi-functional alcohols or into carboxylic acid derivatives. By catalytic transesterification of such carbohydrate derivatives, ester-type diesel-fuel blendstock components may be produced. More specifically, alkyl levulinates are catalytically trans-esterified with hydroxyl-functionalized compounds where both the alcohols and the alkyl levulinates are derived from biomass carbohydrates. Esters produced in this way show physicochemical characteristics that make them suitable for use as diesel fuel blendstock. | 2014-11-27 |
20140350293 | METHOD FOR PRODUCING PRODRUG FROM AMIDOXIME AND N-HYDROXYGUANIDINE CARBOXYLIC ACID ESTERS - The invention relates to a method for improving the bioavailability of pharmaceutical substances and for allowing the pharmaceutical substances to permeate the blood-brain barrier, the pharmaceutical substances having at least one or more amidine, guanidine, N-hydroxyamidine (amidoxime) or N-hydroxyguanidine functions. The invention also relates to medicaments containing the correspondingly modified pharmaceutical substances. | 2014-11-27 |
20140350294 | METHODS OF PRODUCING PARA-XYLENE AND TEREPHTHALIC ACID - The present disclosure provides methods to produce para-xylene, toluene, and other compounds from renewable sources (e.g., cellulose, hemicellulose) and ethylene in the presence of an acid, such as a Lewis acid. For example, cellulose and/or hemicellulose may be converted into 2,5-dimethylfuran (DMF) and 2-methylfuran, which may be converted into para-xylene and toluene, respectively. In particular, para-xylene can then be oxidized to form terephthalic acid. | 2014-11-27 |
20140350295 | METHOD OF SYNTHESIZING LEVOROTATORY P-HYDROXYPHENYLGLYCINE COMPOUNDS - The present invention relates to the field of chemical synthesis, particularly to a method of synthesizing levorotatory p-hydroxyphenylglycine compounds, which eliminates the subsequent processes of resolution, racemization processings, etc., simplifies operational steps; and acids with small organic molecule are chosen as catalyst in the second step, which not only is conducive to the realization of a industrialized production, but also makes the ee value of the end products be 88.1˜98.0% by determining the catalyst, the reaction solvent, the reactive substance, the reaction temperature, and the reaction duration; non-aqueous solvent is used in the second step, to avoid the discharging of phenol-containing waste water, thus environmental pollution is reduced. | 2014-11-27 |
20140350296 | COMPOSITIONS FOR CARBOXYLIC ACID PRODUCTION AND METHODS FOR MAKING AND USING SAME - An alcohol such as methanol is reacted with carbon monoxide in a liquid reaction medium including a catalyst, an alkyl iodide such as methyl iodide, alkyl acetate such as methyl acetate in specified proportions, an additive, and an effective amount of water, where the additive increases an ionic character of the hydrogen iodide bond and the effective amount of water is sufficient to facilitate carboxylic acid release after carbonylation at the catalyst and to reduce anhydride formation. The present reaction system not only provides an acid product at water levels considerable below levels currently used, but also provides unexpected reaction rates and unexpected high catalyst stability. | 2014-11-27 |
20140350297 | Production of Glutaric Acid and Derivatives from Carbohydrate-Containing Materials - The present invention generally relates to processes for the chemocatalytic conversion of a pentose source to a glutaric acid product. The present invention includes processes for the conversion of pentose to a glutaric acid product via pentaric acid or derivatives thereof. The present invention also includes processes comprising the catalytic oxidation of pentose to pentaric acid and catalytic hydrodeoxygenation of pentaric acid or derivatives thereof to a glutaric acid product. | 2014-11-27 |
20140350298 | PROCESS FOR THE (AMM)OXIDATION OF LOWER MOLECULAR WEIGHT ALKANES AND ALKENES - A process for producing unsaturated carboxylic acids or unsaturated nitriles by vapor phase oxidation reaction of their corresponding C | 2014-11-27 |
20140350299 | METHOD AND COMPOSITION FOR INHIBITING ASPHALTENE DEPOSITION IN A HYDROCARBON MIXTURE - A method of inhibiting the deposition of asphaltene in a mixture comprising hydrocarbons, the method comprising contacting the mixture with a composition which comprises at least one poly(hydroxycarboxylic acid) amide salt derivative. | 2014-11-27 |
20140350300 | ALISKIREN HEMIFUMARATE, CRYSTAL FORM AND AMORPHOUS SOLID - Aliskiren hemi fumarate has novel distinctive physico-chemical properties. An amorphous solid is also made of the same Aliskiren hemi fumarate. process for the prepares the forms of Aliskiren hemifumarate. | 2014-11-27 |
20140350301 | NOVEL PROCESSES FOR THE PREPARATION OF PHENYLCYCLOPROPYLAMINE DERIVATIVES AND USE THEREOF FOR PREPARING TICAGRELOR - Provided herein are novel processes for the preparation of phenylcyclopropylamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein are novel, commercially viable and industrially advantageous processes for the preparation of a substantially pure ticagrelor intermediate, trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine. Provided further herein are novel acid addition salts of trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine, and process for their preparation. The intermediate and its acid addition salts are useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof, in high yield and purity. | 2014-11-27 |
20140350302 | (R)-6-(DIMETHYLAMINO)-4,4-DIPHENYLHEPTAN-3-ONE - (R)-6-(dimethylamino)-4,4-diphenylheptan-3-one and a process to produce thereof. | 2014-11-27 |
20140350303 | CATALYSTS FOR THE PRODUCTION OF METHANOL FROM CARBON DIOXIDE - Catalysts for the reduction of CO | 2014-11-27 |
20140350304 | COMPOSITION FOR TREATING DIABETES AND METABOLIC DISEASES AND A PREPARATION METHOD THEREOF - Disclosed is a chalcone composition for treating diabetes and metabolic syndromes. In particular, the chalcone compound bound with 2-halogen in ring A significantly decreases the blood glucose level in the in vitro anti-diabetic effect experiment. In the in vivo animal model, the leading chalcone compound can prevent the progression of diabetes and control the blood glucose level, and there is no significant difference in the gains in body weight. Throughout the seven-week administration, there are no hepatic or renal toxicity observed. | 2014-11-27 |
20140350305 | HYDROFORMYLATION PROCESS - Disclosed is an improved exothermic hydroformylation process having at least two reaction stages. Cooling is provided by externally cooling a stream of reaction mixture from one of the stages, dividing the cooled stream into at least two cooled reaction mixture streams; transferring one cooled reaction mixture stream back into the same reaction stage from which it was removed to cool the reaction mixture in that reaction stage; and transferring at least one cooled reaction mixture stream(s) into and through heat exchange means that cool a different reaction stage, and returning it to the same reaction stage from which it was removed. | 2014-11-27 |
20140350306 | METHOD OF PRODUCING 1-(2-t-BUTYL CYCLOHEXYLOXY)-2-ALKANOL - The present invention relates to [1] a method of producing a 1-(2-t-butylcyclohexyloxy)-2-alkanol including a step of adjusting a raw material mixture containing a 1-(2-t-butylphenyloxy)-2-alkanol represented by the formula (1) to a pH of from 7.5 to 10.0 and hydrogenating it in the presence of a palladium catalyst (A) and a metal catalyst (B) containing one or more kinds of members selected from ruthenium, rhodium, platinum, and nickel; and [2] a perfume composition containing a 1-(2-t-butylcyclohexyloxy)-2-alkanol obtained by the foregoing method. The present invention provides a method of efficiently producing a 1-(2-t-butylcyclohexyloxy)-2-alkanol having a high trans-isomer content and a strong woody or amber-like fragrance as a perfume material and also having excellent persistence of aroma. | 2014-11-27 |
20140350307 | APPARATUS AND METHOD FOR PREPARING ALCOHOL FROM OLEFIN - Disclosed are an apparatus and method for preparing alcohol from olefin. A reactor for hydroformylating olefin comprises a loop reactor for reducing high-boiling point components, a post-treatment device for separating aldehyde comprises a catalyst/aldehyde separator and a divided wall column (DWC) for removing remaining high-boiling point components, and a post-treatment device for separating alcohol comprises a divided wall column (DWC) for removing remaining high-boiling point components. The apparatus and method for preparing alcohol reduce production of high-boiling point components in the preparation of alcohols and efficiently remove remaining high-boiling point components, thus obtaining alcohol containing no high-boiling point components. | 2014-11-27 |
20140350308 | Process For Purifying a Stream Comprising 1,4-Butanediol - A crude product stream of 1,4-butandiol and one or more of γ-butyrolactone, 2-(4-hydroxybutoxy)-tetrahydrofuran, 4-hydroxybutyl(4-hydroxybutyrate), and 3-(4-hydroxybutoxy)-tetrahydrofuran is supplied to a first distillation column. A side-draw of 1,4-butanediol and light components is removed, with the light components including at least some of those produced by reaction in the first distillation column. The stream is passed to a hydrogenation zone and subjected to hydrogenation in the presence of a hydrogenation catalyst. A 1,4-butanediol product stream having a reduced content of 2-(4-hydroxybutoxy)-tetrahydrofuran is recovered and passed to a second distillation column operated such that (4-hyroxybutyl)-4-hydroxybutyrate is removed as a bottom stream and a 1,4-butanediol stream is removed as overhead. The overhead stream removed is passed to a third distillation column and a purified 1,4-butanediol stream is recovered. | 2014-11-27 |
20140350309 | PROCESS FOR PRODUCING 2,3,3,3-TETRAFLUOROPROPENE - The present invention relates, in part, to the discovery that the presence of impurities in a reactor for dehydrochlorinating HCFC-244bb to HFO-1234yf results in a reduced conversion rate and/or a selectivity changeover from HFO-1234yf to HCFO-1233xf. By substantially removing such impurities, it is shown that the conversion rate may be improved and selectivity to HFO-C 1234yf via dehydrochlorination of HCFC-244bb is also improved. | 2014-11-27 |
20140350310 | CATALYTIC PROCESS OF MAKING 1,3,3,3-TETRAFLUOROPROPENE - This disclosure relates to processes of making 1,3,3,3-tetrafluoropropene. The processes involve dehydrofluorinating 1,1,1,3,3-pentafluoropropane in vapor phase in the presence of a catalyst comprising a metal compound supported on alumina to produce a product mixture comprising 1,3,3,3-tetrafluoropropene, wherein said metal compound is selected from the group consisting of salts of sodium, potassium, zinc, magnesium, calcium, cobalt, copper, and chromium, and mixtures thereof. | 2014-11-27 |
20140350311 | METHOD FOR PRODUCING FLUORINATED ORGANIC COMPOUNDS - Disclosed are processes for the production of fluorinated olefins, preferably adapted to commercialization of CF | 2014-11-27 |
20140350312 | METHOD FOR PREPARING 2,3,3,3-TETRAFLUOROPROPENE - Provided are a fluorination catalyst for preparing 2,3,3,3-tetrafluoropropene and a method using the catalyst for preparing 2,3,3,3-tetrafluoropropene. The catalyst has the following structural formula: Crx(Y,Z) | 2014-11-27 |
20140350313 | Additive Composition for Control and Inhibition of Polymerization of Aromatic Vinyl Monomers, and Method of Use Thereof - The present invention relates to an improved additive composition for control and inhibition of polymerization of aromatic vinyl monomers including styrene comprising one or more of aromatic nitro compounds and one or more of aliphatic tertiary amines. In one embodiment, the present invention also relates to method of use of presently provided composition. In another embodiment, the present invention also relates to method of controlling and inhibiting polymerization of aromatic vinyl monomers including styrene by employing presently provided composition. In still another embodiment, the present invention also relates to method of preparation of presently provided composition. | 2014-11-27 |
20140350314 | BIORENEWABLE NAPHTHA - The present technology generally relates to a method for producing a naphtha product from a biorenewable feedstock. The method includes hydrotreating the biorenewable feedstock to produce a hydrocarbon product stream, hydrocracking hydrocarbons from the hydrocarbon product stream to produce a distribution of cracked hydrocarbons, and separating a biorenewable naphtha fraction from the distribution of cracked hydrocarbons. | 2014-11-27 |
20140350315 | METHOD FOR CONVERSION OF AROMATIC HYDROCARBONS - A method of converting hydrocarbons requires contacting a hydrocarbon stream containing alkylated aromatic hydrocarbons with a catalyst of a phosphorus-containing pentasil zeolite in a reactor. The phosphorus-containing pentasil zeolite having a phosphorus content of 7.5% or less by weight of zeolite, a pore volume of at least 0.2 ml/g, and a | 2014-11-27 |
20140350316 | Production of Paraxylene - The process concerns ethylbenzene conversion and xylene isomerization with a catalyst pretreated by sulfiding. | 2014-11-27 |
20140350317 | HYDROGENATION OF CARBOXYLIC ACIDS TO INCREASE YIELD OF AROMATICS - The present invention provides methods, reactor systems, and catalysts for increasing the yield of aromatic hydrocarbons produced while converting carboxylic acids to aromatic hydrocarbons. The invention includes methods of using catalysts to increase the yield of benzene, toluene, and mixed xylenes in the hydrocarbon product. | 2014-11-27 |
20140350318 | Ni/CGO and Ni-Ru/CGO Based Pre-Reforming Catalysts Formulation for Methane Rich Gas Production from Diesel Processing for Fuel Cell Applications - In one aspect, the invention provides a catalyst for converting diesel type liquid hydrocarbons to methane rich gas. The catalyst includes a nickel component, a cerium oxide component, and gadolinium oxide component. The catalysts provide high conversion, selectivity, and stability compare to the state of the art commercial catalysts. The catalyst compositions can improve the overall fuel cell efficiency for both mobile and stationary fuel cell applications. | 2014-11-27 |
20140350319 | PROCESS FOR REMOVING OXYGENATED CONTAMINANTS FROM AN HYDROCARBONSTREAM - The present invention is a process for removing oxygenated contaminants and water from an hydrocarbon stream comprising: | 2014-11-27 |
20140350320 | PROCESSING OF CHLORINE-CONTAINING CARBON-BASED RADIOACTIVE WASTE - A system and method for processing of carbon-based radioactive waste, comprise at least: a) soaking in an acid solution, and b) a heat treatment, of a thermal shock type, said acid solution recovering radioactive material resulting from said waste at least after the implementation of step b). | 2014-11-27 |
20140350321 | PROCESS AND APPARATUS FOR SAFE DISPOSAL OF USED IONIC LIQUID CATALYST - We provide a process and apparatus for preparing a used ionic liquid catalyst for safe disposal, comprising hydrolyzing the used ionic liquid catalyst comprising an anhydrous metal halide with a basic solution at a temperature from −20° C. to 90° C. to produce a hydrolyzed product, evolve a hydrogen halide gas, and dissolve the hydrogen halide gas into the basic solution. | 2014-11-27 |
20140350322 | INTENSITY-MODULATED PROTON THERAPY - The therapeutic treatment of a patient using intensity-modulated proton therapy is described. In one example, a method of creating a proton treatment plan is presented that divides volumes of interest into sub-volumes, applies dose constraints to the sub-volumes, finds one or more feasible configurations of a proton therapy system, and selects a proton beam configuration that improves or optimizes one or more aspects of proton therapy. In some implementations, the method of dividing volumes into sub-volumes includes creating fractional sub-volumes based at least in part on proximity to a target volume boundary. In some implementations, the method of finding an improved or optimal proton beam configuration from a set of feasible configurations includes finding a minimum of a cost function that utilizes weighting factors associated with treatment sites. | 2014-11-27 |
20140350323 | Particulate System For Use in Diminishing Cell Growth/Inducing Cell Killing - The Invention relates to a particulate system for use in diminishing cell growth, in particular the growth of cancer cells, comprising one or more water soluble lanthanide compounds that are embedded in a solid biodegradable polymer particle, the polymer being selected from the group consisting of polycarbonic acids, polylactic acids, polyglycolic acids, polypeptides or combinations thereof. | 2014-11-27 |
20140350324 | PARTICLE BEAM IRRADIATION APPARATUS AND PARTICLE BEAM THERAPY SYSTEM - A scanning power source that outputs the excitation current for a scanning electromagnet and an irradiation control apparatus that controls the scanning power source; the irradiation control apparatus is provided with a scanning electromagnet command value learning generator that evaluates the result of a run-through, which is a series of irradiation operations through a command value for the excitation current outputted from the scanning power source, that updates the command value for the excitation current, when the result of the evaluation does not satisfy a predetermined condition, so as to perform the run-through, and that outputs to the scanning power source the command value for the excitation current such that its evaluation result has satisfied the predetermined condition. | 2014-11-27 |
20140350325 | AFTERLOADING DEVICE, AND USE THEREOF - An afterloading device for effectuating a brachytherapy treatment, comprising a first elongated flexible transport element, arranged to maneuver a radiation source between a storage position inside the afterloading device and a treatment position outside the afterloading device, the afterloading device further comprising a second elongated flexible transport element, having at least one transducer, the second transport element being arranged to move the at least one transducer between a first transducer position and a second transducer position. | 2014-11-27 |
20140350326 | Brachytherapy Seed with Fast Dissolving Matrix for Optimal Delivery of Radionuclides to Cancer Tissue - A system, method and device for treating tumor cells utilizing a resorbable therapy seed made up of microspheres containing a beta- or alpha-particle-emitting radiation source and a resorbable polymer matrix. These seeds are implanted within the tumor and then rapidly dissolved so as to release the microspheres from the polymer matrix. These microspheres then spread within a preselected target area and provide radiation therapy in a predetermined amount and at a preselected rate according the specific needs and necessities of the users. The configuration of the microspheres, the types of radiation provided and the location and use of these microspheres provides desired localized treatment to target cells while preferentially avoiding or minimizing undesired damage to surrounding tissue. The present invention provides a method for making the seeds, as well as a method for utilizing the seeds as a part of the treatment method. | 2014-11-27 |
20140350327 | Device and method for interfering with sympathetic chain signaling for attenuating hot flashes, post-traumatic stress disorder, pain and dysautonomia - Provided herein are a device and method for attenuating posttraumatic stress syndrome, menopause symptoms, dysautonomia and pain by interfering with sympathetic chain signaling, particularly by blocking stellate ganglion conduction. | 2014-11-27 |
20140350328 | CATHETER TO ASSIST THE PERFORMANCE OF A HEART - In a catheter ( | 2014-11-27 |
20140350329 | INORGANIC PYROPHOSPHATE AND USES THEREOF - The present invention provides a new and improved sperm stimulating additive comprising a certain amount of inorganic pyrophosphate (PPi). Addition of PPi in the media for human/animal in vitro fertilization (IVF) improves fertilization rate; addition of PPi in the semen extender for farm animal artificial insemination (AI) may improve pregnancy rates; furthermore, mamalian oocytes matured in vitro in a medium including PPi attain improved fertilization and developmental potential, while embryos cultured in medium supplemented with PPi have improved development to blastocyst. | 2014-11-27 |
20140350330 | EXPANSION INSTRUMENT - An expansion instrument includes an elongated vaginal-insertion member insertable into the vaginal lumen which is adjacent the urethral lumen with biological tissue interposed between the two, an elongated urethral-insertion member insertable into the urethral lumen, an interlock device interlocking the vaginal-insertion member and the urethral-insertion member to allow the insertion members to be brought closer together and brought farther apart, and a vaginal-side restriction that restricts the positional relationship, with respect to the biological tissue, of the vaginal-insertion member after being inserted into the vaginal lumen. The vaginal-side restriction is on the vaginal-insertion member and has a configuration such that in a state where the vaginal-insertion member is in the vaginal lumen, the urethral-insertion member is in the urethral lumen, and the positional relationship has been restricted by the vaginal-side restriction, moving the vaginal-insertion member farther away from the urethral-insertion member widens the biological tissue in the moving away direction. | 2014-11-27 |
20140350331 | Production of materials having an anisotropic structure - The present invention relates to a process for the production of a multi-layered material having anisotropic pores. It further relates to a multi-layered material which can be produced by the process according to the invention, and to the use of a multi-layered material as a chondral support matrix, a meniscus support matrix or an intervertebral disc support matrix. | 2014-11-27 |
20140350332 | SYSTEM FOR TREATING PELVIC ORGAN PROLAPSE INCLUDING A SHELL AND AN ANCHOR - A system for treating pelvic organ prolapse includes a shell and an anchor. The shell is made of biodegradable material that is insertable into a vagina. The shell has a convex exterior apex that is sized to contact an interior apical portion of the vagina. The anchor has a proximal portion that is attachable to the apex of the shell and a distal portion that is provided with a tissue fixation device that is attachable to tissue exterior the vagina such that the anchor and the shell combine to support and elevate the interior apical portion of a vagina. | 2014-11-27 |
20140350335 | ENDOSCOPIC DEVICE AND SYSTEM - An endoscopic system may include a catheter or tubing and at least one optical sensor disposed along the catheter or tubing and configured to capture image information from a body lumen when disposed within the body lumen and activated. The system may further include an untethered module operatively arranged with the at least one optical sensor and configured to store or transmit image information captured by the at least one optical sensor. The catheter or tubing, at least one optical sensor and module may be portable during use. | 2014-11-27 |