| 47th week of 2021 patent applcation highlights part 23 |
| Patent application number | Title | Published |
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| 20210363048 | METHOD AND APPARATUS OF MANUFACTURING GLASS PRODUCTS - Provided is a method of manufacturing a glass product including the following steps. An intermediate glass product is provided. A portion of the intermediate glass product is heated to a predetermined temperature. A tool and the heated portion of the intermediate glass product are brought into contact. Under a state that a tool contacts the heated portion, at least one of the tool and the intermediate glass product is rotated so that the tool and the intermediate glass product relatively rotate, wherein a part of the tool that contacts the heated portion comprises or is made of glassy carbon. | 2021-11-25 |
| 20210363049 | NOZZLE STRIP FOR A BLOW BOX FOR THERMALLY PRESTRESSING GLASS PANES - A nozzle strip for a blow box for thermally prestressing glass panes, which nozzle strip has a row of nozzles each having a nozzle inlet and a nozzle opening for impinging on a surface of a glass pane with a stream of air through the nozzle openings, wherein the nozzle openings are arranged on merlon-like elevations of a side surface of the nozzle strip. | 2021-11-25 |
| 20210363050 | LASER-INDUCED SEPARATION OF TRANSPARENT OXIDE GLASS - A method of cutting a glass sheet comprising a transparent oxide glass includes directing a laser beam from a middle-infrared (mid-IR) laser source onto a major surface of the glass sheet. A wavelength of the laser beam is tuned thereby adjusting an absorption depth of the laser beam in the glass sheet. The glass sheet is cut using the laser beam. | 2021-11-25 |
| 20210363051 | ALKALI-FREE GLASS - An alkali-free glass includes, in mol % in terms of oxides: SiO | 2021-11-25 |
| 20210363052 | GLASS COMPOSITION AND COOKING APPLIANCE - Provided is a glass composition comprising a glass frit containing P | 2021-11-25 |
| 20210363053 | METHOD FOR PRODUCING AN ELECTRONIC STRUCTURE ON A GLASS PANE AND GLASS SHEET HAVING AT LEAST ONE GLASS PANE OF THIS TYPE - A method for producing an electronic structure on a glass pane which has, at least on one of its two glass pane surfaces, a functional coating having at least one electrically conductive functional layer, preferably having multiple electrically conductive functional layers, the functional coating being structured by means of laser radiation in such a way that the electronic structure, preferably a capacitive sensor system or a conductor loop, is created. A glass sheet having at least one glass pane of this type. | 2021-11-25 |
| 20210363054 | METHOD FOR MANUFACTURING A COATED CHEMICALLY STRENGTHENED GLASS ARTICLE - A method of manufacturing a coated glass article that includes (i) preparing a glass substrate having a first and second opposed main surfaces, (ii) irradiating at least the first main surface of the glass substrate with a laser to form at least one separating line defining contour lines, for dividing at least one glass article from the glass substrate, the glass article having a shape and/or size different from the glass substrate of step (i), (iii) chemically strengthening the glass substrate on which at least one separating line is formed, the separating line extending in a depth direction from the first main surface to the second main surface, and (iv) separating of the at least one glass article from the glass substrate according to the at least one separating line. In addition, the glass substrate is coated between steps (iii) and (iv). | 2021-11-25 |
| 20210363055 | APPLYING PROTECTIVE COATINGS TO OPTICAL FIBERS - Apparatus, systems, and methods that provide coats on a glass optical fiber including of an inner layer and an outer layer. The method includes two steps. First, a conductive polymer coating is applied to the optical fiber as it is being produced. Second, a protective coating is applied to that conductive polymer coating. The conductive polymer coating is applied immediately after the fiber is drawn from preform to fiber. | 2021-11-25 |
| 20210363056 | TWISTED REINFORCEMENT FIBERS AND METHOD OF MAKING - A concrete structure formed of a mixture of concrete and a plurality of custom manufactured twisted steel micro-rein-forcements (TSMRs). Each TSMR has a twist pitch of two or more twists per 25.4 mm applied along its longitudinal axis. The TSMRs are made from a common base stock and have the number of twists predetermined such that a concrete structure formed with at least 10 wt. % per unit volume less TSMRs than fibers in a conventional concrete structure exhibits the same or better performance than the conventional concrete structure in one or more of a stress, deflection, energy, or crack mouth opening (CMOD) properties as determined through defined standard tests. The performance requirement may be based on the actual test result and/or the consistency (coefficient of variation of the result). | 2021-11-25 |
| 20210363057 | NOVEL METHOD OF PRODUCING IMPROVED LIGHTWEIGHT CERAMIC SAND AND USES THEREOF - The present invention discloses a novel, improved, simple and economic process for manufacturing lightweight ceramic sand. The lightweight ceramic sand is produced from the industrial wastes, wherein the major raw materials are fly ash, bauxite residue and biomass-coal fly ash. The present invention relates to the production of new fine particulates at high throughput and at low manufacturing cost to provide an alternative or substitute to the fast-depleting natural sand including crushed stones and lightweight fine aggregates produced from expanded clay, expanded glass and volcanic activities. Lightweight ceramic sand of the present invention can be used as a building and construction material and foundry sand. | 2021-11-25 |
| 20210363058 | CEMENT AND PROCESS FOR PRODUCING SELF-PROTECTING CEMENT - A process for producing cement includes combining a cement precursor and a wax, wherein the wax includes alkyl ketene dimer wax and/or alkenyl ketene dimer wax, grinding the cement precursor and the wax to yield cement grains coated with the wax. A cement includes cement powder grains and a coating of wax on the Portland cement powder grains, wherein the wax includes alkyl ketene dimer wax and/or alkenyl ketene dimer wax. A process for making cementitious material includes combining a cement with water to yield a slurry, wherein the cement includes cement powder grains and a coating of wax on the cement powder grains, wherein the wax includes alkyl ketene dimer wax and/or alkenyl ketene dimer wax, and allowing the slurry to set. | 2021-11-25 |
| 20210363059 | NATURAL MATERIAL-BASED ASH MORTAR COMPOSITION - A mortar composition, which includes (i) a treated palm oil fuel ash, wherein the treated palm oil fuel ash is the only binder present, (ii) a fine aggregate, (iii) an alkali activator containing an aqueous solution of sodium hydroxide and sodium silicate, and (iv) aluminum hydroxide as a strength enhancer. A cured mortar made from the mortar composition is also disclosed with advantageous compressive strength properties. | 2021-11-25 |
| 20210363060 | Chemical-Resistant Quartz-Based Casting Composition - A quartz-based casting composition provides excellent resistance to attack by chemicals, including weak and strong acids. The quartz-based casting composition is useful as concrete in various construction applications where corrosion resistance is needed. The casting composition includes a dry component and a wet component. The dry component includes about 25% to about 100% by weight quartz and the corrosion resistance increases with increasing quartz content. | 2021-11-25 |
| 20210363061 | Method of Making Chemical-Resistant Quartz-Based Concrete - A method of making a chemical-resistant concrete composition, namely a quartz-based casting composition, is provided. The quartz-based casting composition provides excellent resistance to attack by chemicals, including weak and strong acids. The quartz-based casting composition is useful as concrete in various construction applications where corrosion resistance is needed. The casting composition includes a dry component and a wet component. The dry component includes about 25% to about 100% by weight quartz and the corrosion resistance increases with increasing quartz content. | 2021-11-25 |
| 20210363062 | TWO-COMPONENT SYSTEM FOR FORMATION OF COHESIVE BONDS OR FOR CHEMICAL ANCHORING - A two-component system for forming adhesive bonds or for chemical anchoring comprises a curable binder component A and an activator component B. The component A comprises: A-1) an inhibited hydraulic binder selected from among calcium aluminate cement, calcium sulfoaluminate cement and mixtures thereof; the component B comprises: B-1) a curing activator. At least one of the components A and/or B comprises: V-1) an organic binder; and V-2) a filler having a Mohs hardness of at least 5. The system is an aqueous system which is unproblematical from a health point of view. It is easy to process and quickly attains high strengths. | 2021-11-25 |
| 20210363063 | CERAMIC PARTICULATE MIXTURE COMPRISING COAL COMBUSTION FLY ASH - A non-spray-dried, dry-granulated ceramic particulate mixture including at least 40 wt % coal combustion fly ash and from 4 wt % to 9 wt % water. At least 90 wt % of the particles have a particle size of from 80 μm to 600 μm. | 2021-11-25 |
| 20210363064 | BATCH COMPOSITIONS COMPRISING PRE-REACTED INORGANIC PARTICLES AND METHODS OF MANUFACTURE OF GREEN BODIES THEREFROM - Batch compositions containing pre-reacted inorganic spheroidal particles, small amount of fine inorganic particles (“fines”), and an extremely large amount of liquid vehicle. The batch compositions contain pre-reacted inorganic particles having a particle size distribution with 20 μm≤D50≤100 μm, D90≤100 μm, and D5≥10 μm; less than 20 wt % of fine inorganic particles (fines) whose particle distribution(s) have a median diameter of less than 5 μm; and a liquid vehicle in a weight percent (LV %≥28%) by super-addition to all inorganic particles in the batch composition. Fast extruding batch compositions having extremely high Tau Y/Beta ratios are provided. Green bodies, such as green honeycomb bodies and methods of manufacturing green honeycomb bodies are provided, as are other aspects. | 2021-11-25 |
| 20210363065 | LITHIUM-GARNET COMPOSITE CERAMIC ELECTROLYTE - A sintered composite ceramic, including: a lithium-garnet major phase; and a lithium-rich minor phase, such that the lithium-rich minor phase comprises Li | 2021-11-25 |
| 20210363066 | PROCESS FOR THE MANUFACTURE OF A FUSED BLOCK HAVING A HIGH ZIRCONIA CONTENT - A process for the manufacture of a refractory block including more than 80% zirconia, in percentage by weight based on the oxides. The process includes the following successive stages: melting, under reducing conditions, of a charge including more than 50% zircon, in percentage by weight, such as to reduce the zircon and obtain a molten material, application of oxidizing conditions to the molten material, casting of the molten material, and cooling until at least partial solidification of the molten material in the form of a block. Also, the process can include heat treatment of the block. | 2021-11-25 |
| 20210363067 | LOW TEMPERATURE CARBON/BN/ALUMINUM OXIDE COATING - A method of forming an activated coating composition is disclosed. The method includes providing (a) boron nitride, (b) carbon, (c) aluminum oxide and (d) a liquid carrier. Each of the boron nitride, carbon and aluminum oxide are in particulate form. The coating composition is activated to form an activated coating composition. The activated coating composition includes active components having from about 60.0 wt % to about 90.0 wt % boron nitride, from about 16 wt % to about 24 wt % carbon and from about 4 wt % to about 6 wt % aluminum oxide. A coating method, coated substrate and activated coating composition are also disclosed. | 2021-11-25 |
| 20210363068 | MULTILAYER ZIRCONIA CERAMIC BLOCK WITH UNIFORM TRANSITION AND METHOD FOR PREPARING THE SAME - The present disclosure belongs to the field of biological materials, and particularly relates to a multilayer zirconia ceramic with uniform transition and a method for preparing the same. The specific technical solution of the present disclosure is as follows: a zirconia ceramic with a formula comprising, in percentage by mass, 0-3% of lanthana, 1.5-16% of yttria, 0-2.5% of silicon carbide nano-whiskers, and 0-1.5% of a coloring agent, the balance being zirconia. Correspondingly provided are a multi-layer zirconia ceramic with uniform transition prepared using the formula and a method for preparing the same. By using the method of the present disclosure, multilayer zirconia ceramics with good and uniformly transitioning core properties can be quickly and conveniently prepared, meeting the requirements of patients with dental disorders on the use and esthetics of dentures. | 2021-11-25 |
| 20210363069 | METHOD TO PRODUCE DENSE CERAMIC MATRIX COMPOSITES - Disclosed is a method for making a ceramic matrix composite. The method includes infiltrating an initial ceramic matrix composite with a molten silicon infiltration material to form a silicon infiltrated composite; cooling the silicon infiltrated composite; heating a first portion of the cooled silicon infiltrated composite to a temperature in excess of the melt temperature of the silicon infiltration material in the presence of a carbon source; heating a second portion of the cooled silicon infiltrated composite to a temperature in excess of the melt temperature of the silicon infiltration material in the presence of a carbon source after heating the first portion; and cooling the heated portions to form a final ceramic matrix composite, wherein the first portion and second portion of the cooled silicon infiltrated composite are adjacent or overlap. | 2021-11-25 |
| 20210363070 | FERTILIZER COMPOSITION - A fertilizer composition comprising an ammonium nitrate material and an effective amount of a stabilizer material to result in a specific impulse reduction of at least 10% when compared the specific impulse of a commercially available ammonium nitrate composition. The stabilizer material may comprise huntite or magnesite. In one embodiment, stabilizer material is about 10 to about 25 wt. % of the total fertilizer composition. | 2021-11-25 |
| 20210363071 | MICROALGAE ENHANCED BIOLOGICAL CROP NUTRITION GRANULES - A combined microalgae and mycorrhizal fungi granular formulation includes a microalgae inoculant combined with a mycorrhizal fungi inoculant with demineralized water to maintain moisture and applied to carrier granules such as a natural clay-based or mineral-based material. The coated granules are dried and may be applied to agricultural areas in dried granular form. | 2021-11-25 |
| 20210363072 | FERTILIZERS DERIVED FROM DATE SYRUP - The fertilizers derived from date syrup may include date sugar acids chelated to at least one metal ion useful for promoting plant growth. The date acids may be synthesized from waste or non-consumable dates. The fertilizers derived from date syrup may be synthesized by extracting date syrup from dried dates, oxidizing the date syrup to obtain date acids, and chelating the date acids to at least one metal ion. The at least one metal ion may be selected from the group consisting of potassium, calcium, magnesium, copper, iron, manganese, molybdenum, zinc, and a combination thereof. | 2021-11-25 |
| 20210363073 | SMART RELEASE NITROGEN-CONTAINING FERTILIZER GRANULES - There is provided a nitrogen fertilizer granule in which the nitrogen release can be timed and the nitrogen release rate can be controlled according to the needs of the plants to be fertilized. The smart release nitrogen-containing fertilizer granule comprises a nitrogen-containing fertilizer core; an organic functional layer covering the core, wherein the organic functional layer comprises at least one functional organic compound that is an enzyme inhibitor, a microbial suppressor, a phosphorus solubilizer, and/or a plant hormone; a controlled release layer covering the organic functional layer, wherein the controlled release layer comprises water-swellable copolymeric nanoparticles; and an anticaking layer covering the controlled release layer, wherein the anticaking layer comprises water-insoluble copolymeric nanoparticles. | 2021-11-25 |
| 20210363074 | METHOD FOR PREPARING ETHYLENE AND APPARATUS FOR PREPARING ETHYLENE - A method for preparing ethylene, including: passing a feed stream containing C1 and C2 hydrocarbon compounds through a first heat exchanger and feeding the feed stream passed through the first heat exchanger to a second gas-liquid separator; feeding a part of a bottom discharge stream of the second gas-liquid separator to a demethanizer, passing an overhead discharge stream of the second gas-liquid separator through a second heat exchanger, feeding the overhead discharge stream of the second gas-liquid separator passed through the second heat exchanger to a third gas-liquid separator; feeding a bottom discharge stream of the third gas-liquid separator to the demethanizer; feeding a bottom discharge stream of the demethanizer to a C2 separator; feeding an overhead discharge stream of the C2 separator to a second compressor; passing a part of a compressed discharge stream of the second compressor through the first heat exchanger and feeding the part of the compressed discharge stream of the second compressor passed through the first heat exchanger to the second compressor as a first circulation flow; passing a part of the compressed discharge stream of the second compressor through the second heat exchanger and feeding the part of the compressed discharge stream of the second compressor passed through the second heat exchanger to a first compressor as a second circulation flow; and feeding a compressed discharge stream of the first compressor to the second compressor, and an apparatus for preparing ethylene for implementing the same. | 2021-11-25 |
| 20210363075 | METHOD OF REFINING RAFFINATE-2 - A method for separating and refining 1-butene with a high purity and a high yield from a raffinate-2 stream. The method includes: feeding raffinate-2 to a first distillation column; obtaining heavy raffinate-3 from a lower part of the first distillation column; recovering an upper part fraction containing 1-butene from an upper part of the first distillation column; feeding the upper part fraction containing 1-butene to a second distillation column; recovering a first lower part fraction rich in 1-butene from a lower part of the second distillation column and light raffinate-3 from an upper part of the second distillation column. Heat of the upper part fraction recovered from the upper part of the first distillation column is fed to the lower part of the second distillation column through a first heat exchanger. Thus, 1-butene is obtained with high purity and high yield while maximizing an energy recovery amount by double-effect distillation. | 2021-11-25 |
| 20210363076 | METHOD FOR PREPARING 2-METHYLALLYL CHLORIDE FROM 1,2-DICHLOROTERT-BUTANE - The present invention relates to a method for preparing 2-methylallyl chloride from 1,2-dichloro-tert-butane. The method is characterized in that 1,2-dichloro-tert-butane and a sodium hydroxide aqueous solution are used as raw materials; reactive rectification is performed in a combined rectifying tower to eliminate hydrogen chloride so as to obtain 2-methylallyl chloride. A plate type tower is provided at the lower part of the combined rectifying tower; a packing tower is provided at the upper part of the combined rectifying tower; an inner reflux condenser is provided at the top of the combined rectifying tower. The sodium hydroxide aqueous solution is added from a first plate of the plate type tower; and 1,2-dichloro-tert-butane is added from the middle part of the plate type tower. The method has the advantages that the raw material 1 and | 2021-11-25 |
| 20210363077 | METHOD FOR PRODUCING DIFLUOROMETHYLENE COMPOUND - The problem to be solved by the present invention is to provide a novel method for producing a difluoromethylene compound, in particular, a simple method for producing a difluoromethylene compound. This problem is solved by a method for producing a difluoromethylene compound (I) containing at least one —CF | 2021-11-25 |
| 20210363078 | METHOD FOR PRODUCING TETRAFLUOROMETHANE - Provided is a method for producing tetrafluoromethane, and the method is unlikely to damage a reaction apparatus and can produce tetrafluoromethane safely, inexpensively, and stably. To a raw material liquid ( | 2021-11-25 |
| 20210363079 | PROCESS FOR THE PREPARATION OF METHANOL - Process for the preparation of a methanol product comprising the steps of a) providing a first process stream consisting essentially of carbon dioxide; b) providing a second process stream consisting of hydrogen by electrolyzing water in an electrolysis unit; c) mixing the first and second process in amount to obtain a methanol synthesis gas with a mole ratio of H2 and CO2 of between 2.5 and 3.5; d) catalytic converting the methanol synthesis gas into raw methanol in at least one methanol reactor; e) purifying the raw methanol in a distillation unit; and recovering waste heat generated in the electrolysis unit in step (b) by transferring the waste heat to a circulating heat transfer medium by indirect heat exchange with the waste heat and by indirect heat exchange of the heated heat transfer medium with steam used for the distillation of the raw methanol, wherein the heated transfer medium is compressed upstream the indirect heat exchange with steam. | 2021-11-25 |
| 20210363080 | PROCESSES FOR PRODUCING ALCOHOLS FROM BIOMASS AND FURTHER PRODUCTS DERIVED THEREFROM - Processes for producing alcohols from biomass are provided. The processes utilize supercritical methanol to depolymerize biomass with subsequent conversion to a mixture of alcohols. In particular the disclosure relates to continuous processes which produce high yields of alcohols through recycling gases and further employ dual reactor configurations which improve overall alcohol yields. Processes for producing higher ethers and olefins from the so-formed alcohols, through alcohol coupling and subsequent dehydration are also provided. The resulting distillate range ethers and olefins are useful as components in liquid fuels, such as diesel and jet fuel. | 2021-11-25 |
| 20210363081 | ALCOHOL SOLVENT RECOVERY AND PLANT OIL DECARBOXYLATION APPARATUS AND METHOD - A method of and apparatus for recovering an alcohol solvent from a liquid mixture of the solvent and plant oil and decarboxylating the plant oil may include, pressurizing the liquid mixture to a super-atmospheric pressure, recirculating the pressurized liquid mixture a plurality of times through at least one membrane separator to separate some of the solvent from the mixture to provide a concentrated mixture of the plant oil with less solvent, reducing the pressure of the liquid concentrated mixture to less than 15 psig, heating it at a pressure of less than 15 psig to a temperature sufficient to vaporize the solvent in the concentrated mixture, removing sufficient heat from the vaporized solvent to condense it to a liquid solvent at atmospheric pressure and temperature conditions, and heating the plant oil to a temperature desirably of at least 215° F. to decarboxylate the plant oil. | 2021-11-25 |
| 20210363082 | TREATMENT OF RESIDUAL STREAMS FROM THE MANUFACTURE OF BISPHENOLS - A method is disclosed for treating a residual stream from bisphenol manufacture, wherein the residual stream comprises unreacted phenols, bisphenol isomers, trisphenols, organic sulfides and water. The method comprises contacting at least a portion of the residual stream or a reaction product thereof with an acidic catalyst under conditions sufficient to allow acid-catalyzed hydrolysis of organic sulfides in the residual stream to the corresponding thiols and produce an effluent stream, and then distilling at least a portion of the effluent stream to recover distillate products comprising phenols and thiols and produce a bottoms product comprising bisphenol isomers and trisphenols, and having a lower content of organic sulfides than the residual stream. | 2021-11-25 |
| 20210363083 | PROCESS FOR SEPARATING A CONSTITUENT/CANNABINOID USING A CHROMATOGRAPHIC RESIN - A method for purification and separation of cannabinoids, such as cannabidiol and tetrahydrocannabinol, e.g., from dried hemp and | 2021-11-25 |
| 20210363084 | Etherification Process - The present invention relates to a process for preparing ethers, particularly unsymmetrical ethers, and preferably ethers suitable for use as base stocks for lubricant compositions. In particular, the process involves the reaction of an α,β-unsaturated aldehyde with a trihydrocarbyl orthoester to form an α,β-unsaturated acetal and conversion of the α,β-unsaturated acetal to an ether through hydrogenation and hydrogenolysis. | 2021-11-25 |
| 20210363085 | PROCESSES FOR PRODUCING ETHERS AND OLEFINS FROM PRIMARY ALCOHOLS - Provided are two-stage processes by which primary alcohols such as ethanol or 1-butanol are converted into distillate-range ethers and olefins utilizing Guerbet coupling followed by intermolecular dehydration. The ethers can be used, for example, as cetane-improvers in diesel fuel, while the olefins can be hydrogenated to afford paraffins. | 2021-11-25 |
| 20210363086 | BIOBASED ALKYL GLYCERYL ETHERS AND METHODS OF MAKING AND USING THE SAME - The present invention relates to biobased alkyl, alkenyl, or alkynyl glyceryl ether compounds and compositions and formulations comprising same, processes for preparing the inventive biobased compounds, as well as applications thereof including the use of the inventive compounds and compositions in formulations of products or components of products. | 2021-11-25 |
| 20210363087 | Chemical Conversion of Carbon Dioxide and Gaseous Hydrocarbons to Solvents - Catalytic chemical conversion of carbon dioxide gas combined with a hydrocarbon gas, comprising natural gas, methane, ethane, propane, butane or pentane, over a transition metal oxide, produces organic solvent products. The process converts oxidized carbon compounds to valued organic products and can reduce or eliminate the carbon footprint of industrial electric power generation industry. Catalytic processes are taught for chemical conversion of oxides of carbon, principally carbon dioxide (formed by combustion of hydrocarbons), to solvent compounds comprising acetone, butanol, pentane and related organic products. The catalysts are transition metal oxides, selected from the group comprising manganese, iron and cobalt or combinations thereof. | 2021-11-25 |
| 20210363088 | METHOD FOR MANUFACTURING 1,4-BIS (4-PHENOXYBENZOYL)BENZENE AT AN ELEVATED TEMPERATURE - A method for manufacturing 1,4-bis(4-phenoxybenzoyl)benzene, including: providing a solvent, a Lewis acid, a first reactant and a second reactant, wherein the first reactant and the second reactant are respectively terephthaloyl chloride and diphenyl ether, or reversely; mixing the first reactant in the solvent to make a starting mixture; and, adding the second reactant to the starting mixture; wherein the Lewis acid is mixed, at least partly, to the starting mixture before adding the second reactant to the starting mixture, and/or wherein the Lewis acid is mixed, at least partly, with the second reactant and added together to the starting mixture, and wherein the temperature of the starting mixture is greater than 5° C. during at least part of the step of adding the second reactant to the starting mixture; so as to obtain a product mixture comprising a 1,4-bis(4-phenoxybenzoyl)benzene-Lewis acid complex. | 2021-11-25 |
| 20210363089 | CONTINUOUS PROCESS FOR PREPARING METHACROLEIN - Methacrolein is prepared in a continuous process by a Mannich condensation reaction of formaldehyde with propanal. A methacrolein polymerization inhibitor is introduced during the production process and a part thereof is recycled back into the reactor where the Mannich condensation reaction is carried out. | 2021-11-25 |
| 20210363090 | METHOD AND APPARATUS TO PRODUCE FATTY ACIDS FROM METHYL ESTERS THROUGHOUT NON-CATALYTIC PROCESS - An autocatalytic process for producing fatty acids from fatty acids methyl esters with an overall conversion higher than 90% which includes multiple hydrolysis reactions in series, in purely thermal conditions, with intermediate separation of phases after each hydrolysis reaction and before the subsequent, operating in excess of water, in order to separate the methanol/water phases from the equilibrium phase and favor the formation of fatty acids product. | 2021-11-25 |
| 20210363091 | ELECTRIC HEATING OF BOILER FEEDWATER IN THE MANUFACTURE OF PURIFIED AROMATIC CARBOXYLIC ACIDS - Processes for manufacturing purified aromatic carboxylic carboxylic acids includes: generating high-pressure steam ( | 2021-11-25 |
| 20210363092 | METHOD FOR PURIFYING ORGANIC ACIDS - Provided is a method for purifying organic acids, comprising:
| 2021-11-25 |
| 20210363093 | BEXAROTENE DERIVATIVES AND THEIR USE IN TREATING CANCER - This disclosure relates to compositions and methods for treating cancer. Specifically, this disclosure relates to bexarotene derivatives, methods for treating cancer, autoimmune disorders, and/or skin dermatitis, and/or methods for increasing peripheral blood counts and/or improving immune system function. | 2021-11-25 |
| 20210363094 | A METHOD FOR PRODUCTION OF METHYL METHACRYLATE BY OXIDATIVE ESTERIFICATION USING A HETEROGENEOUS CATALYST - A method for preparing methyl methacrylate from methacrolein and methanol. The process comprises contacting in a reactor a mixture comprising methacrolein, methanol and oxygen with a heterogeneous catalyst comprising a support and a noble metal, wherein said catalyst has an average diameter of at least 200 microns, liquid and gaseous reactants flow downward in the reactor and wherein the continuous phase in the reactor is a gas which has no more than 7.5 mol % oxygen at reactor inlets. | 2021-11-25 |
| 20210363095 | METHOD CAPABLE OF REALIZING PREPARATION AND IN-SITU SEPARATION OF OLIGOMERIC RICINOLEATE - The disclosure is about a method capable of realizing the preparation and in-situ separation of the oligomeric ricinoleate, which uses the ricinoleic acid as raw material, and uses a protonic acid-type ionic liquid as a catalyst to cause the dehydration and esterification reactions between ricinoleic acid molecules. By continuously distilling out the generated water under a reduced pressure, the oligomeric ricinoleate with a polymerization degree of 2 to 10 is obtained. After the reaction, a method of washing with water or static stratification is selected to recover the catalyst according to the miscibility of the catalyst and reaction system. In his disclosure, renewable raw materials are used, the process is clean and pollution-free, and the operation is simple. | 2021-11-25 |
| 20210363096 | COMPOUND, MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMINTS, ORGANIC ELECTROLUMINESCENT ELEMENT AND ELECTRONIC DEVICE - A compound represented by formula (1) provides a high performance organic electroluminescence device and a novel material for realizing such an organic electroluminescence device: | 2021-11-25 |
| 20210363097 | METHOD FOR PRODUCING C2-C4 MONO ALKANOL AMINES USING AN ACID CATION EXCHANGER AS A CATALYST - A process for continuous production of C | 2021-11-25 |
| 20210363098 | DIVERSITY-ORIENTED SYNTHESIS OF N,N,O-TRISUBSTITUTED HYDROXYLAMINES FROM ALCOHOLS AND AMINES BY N-O BOND FORMATION - In one aspect, the disclosure relates to a method for the direct synthesis of complex N,N,O-trisubstituted hydroxylamines by N—O bond formation. In another aspect, the method can successfully be employed using a wide variety of commercially available alcohols and secondary amines and enables the construction of large fragment-based libraries of trisubstituted hydroxylamines for drug discovery purposes. Also disclosed are N,N,O-trisubstituted hydroxylamines having low basicity, high stability at ambient temperatures, and an inherent lack of reactivity towards acetylating and sulfonylating enzymes that confer mutagenicity on less-substituted hydroxylamines. | 2021-11-25 |
| 20210363099 | METHOD FOR PREPARING ALIPHATIC ISOCYANATE - The present invention relates to a method for preparing aliphatic isocyanate. More specifically, the present invention relates to a high purity isocyanate preparation method that can effectively recover unreacted materials and recycle them to a reaction step, and reduce energy consumed when separating reactants. | 2021-11-25 |
| 20210363100 | A UREA PRODUCTION PROCESS AND PRODUCTION PLANT USING CO2 PRODUCTED BY OXY-COMBUSTION - A urea production process comprises a step of synthesis of urea by reaction of ammonia and carbon dioxide, where at least part of the carbon dioxide for the urea reaction synthesis is produced in an oxy-combustion process; the oxy-combustion process is specifically a flameless oxy-combustion process. | 2021-11-25 |
| 20210363101 | CRYSTALLINE FORMS OF GFT-505, PROCESSES FOR PREPARATION AND USE THEREOF - The present disclosure relates to novel crystalline forms of GFT-505, processes for preparation and uses thereof. The crystalline form CS1, crystalline form CS2, crystalline form CS5 and crystalline form CS6 of GFT-505 provided by the present disclosure have high purity, good stability, low hygroscopicity, good solubility and good mechanical stability. The present disclosure provides a new and better choice for the preparation of drug products containing GFT-505 and is of great significance for drug development. | 2021-11-25 |
| 20210363102 | SULFONIUM SALT PHOTOINITIATOR, PREPARATION METHOD THEREFOR, PHOTOCURABLE COMPOSITION COMPRISING SULFONIUM SALT PHOTOINITIATOR, AND USE THEREOF - The present invention provides a sulfonium salt photoinitiator, a preparation method therefor, a photocurable composition comprising sulfonium salt photoinitiator, and use thereof. The sulfonium salt photoinitiator has a structure represented by formula (I). By modifying the structure of an existing sulfonium salt photoinitiator, a sulfonium salt photoinitiator having a new structure is obtained, which can exhibits a higher photosensitivity and an excellent as well as characteristics of low odor and low toxicity, when being used in a photocurable composition. This is significantly superior to existing similar photoinitiators. | 2021-11-25 |
| 20210363103 | CRYSTALLINE FORMS OF ERAVACYCLINE - The invention relates to crystalline forms of the bis-HCl salt of a compound represented by Structural Formula 1, and pharmaceutical compositions comprising crystalline forms of the bis-HCL salt of a compound represented by Structural Formula 1 described herein. The crystalline forms of the bis-HCl salt of a compound of Structural Formula 1 and compositions comprising the crystalline forms of the compound of Structural Formula 1 provided herein, in particular, crystalline Form I, crystalline Form J, crystalline Form A, and crystalline Form B, or mixtures thereof, can be incorporated into pharmaceutical compositions, which can be used to treat various disorders. Also described herein are methods for preparing the crystalline forms (e.g., Forms I, J, B and A) of the bis-HCl salt of a compound represented by Structural Formula 1. | 2021-11-25 |
| 20210363104 | DEUTERATED TRYPTAMINE DERIVATIVES AND METHODS OF USE - The present disclosure is directed to chemical compounds and to the use of such compounds in the treatment of diseases associated with a serotonin 5-HT | 2021-11-25 |
| 20210363105 | CRYSTALLINE (R)-5-CARBAMOYLPYRIDIN-3-YL-2-METHYL-4-(3-(TRIFLUOROMETHOXY)BENZYL)PIPERA- ZINE-1-CARBOXYLATE, COMPOSITIONS AND METHODS OF USE THEREOF - Provided herein are crystalline forms of (R)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl)piperazine-1-carboxylate. Pharmaceutical compositions comprising crystalline forms of (R)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl)piperazine-1-carboxylate are also disclosed. | 2021-11-25 |
| 20210363106 | PROCESS FOR PRODUCING SUBSTITUTED 2-ALLYLANILINES AND SUBSTITUTED 4-AMINOINDANES - The present invention primarily relates to a process for producing certain substituted 2-allylanilines of the hereinbelow-defined formula (I) and their use in a process for producing substituted 4-aminoindane derivatives of the hereinbelow-defined formula (V). The present invention further relates to a process for producing fungicidal indanyl carboxamides. In particular, the present invention relates to a process for producing 2-(difluoromethyl)-N-(1,1-dimethyl-3-propyl-2,3-dihydro-1H-inden-4-yl)nicotinamide and/or 3-(difluoromethyl)-N-[(R)-2,3-dihydro-1,1,3-trimethyl-1H-inden-4-yl]-1-methylpyrazole-4-carboxamide. | 2021-11-25 |
| 20210363107 | MICROBIOCIDAL COMPOUNDS - Compounds of the formula (I), wherein the substituents are as defined in claim | 2021-11-25 |
| 20210363108 | Derivatives of 4-aminoantipyrine as anti-Alzheimers butyrylcholinesterase inhibitors - One embodiment of the invention relates to the treatment of diseases associated with increased butyrylcholinesterase (BuChE) enzyme activity such Alzheimer's Disease (AD), involving administering an effective amount of a compound selected from a group of new N, N′-disubstituted benzylamine derivatives (1-8) of 4-aminoantipyrine (ampyrone). The kinetic studies of two potent compounds 4-(Bis(4-iodobenzyl) amino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one (5) (IC | 2021-11-25 |
| 20210363109 | PHENYL CYCLOHEXANONE DERIVATIVES AND METHODS OF MAKING AND USING THEM - Phenyl cyclohexanone based active agents, pharmaceutical preparations containing such active agents, methods of modifying cellular activity by contacting cells with such active agents, and methods of treating various conditions by administering such active agents to a patient are described. | 2021-11-25 |
| 20210363110 | 4-METHYLDIHYDROPYRIMIDINONE COMPOUNDS AND PHARMACEUTICAL USE THEREOF - The present invention relates to 4-methyldihydropyrimidinone compounds, or pharmaceutically acceptable salts thereof, having RORγ antagonist activity, pharmaceutical compositions comprising the same, and pharmaceutical use thereof. A compound of Formula (1) or (2) or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same, and pharmaceutical use thereof are provided. | 2021-11-25 |
| 20210363111 | METHODS OF COUPLING A CARBON CONTAINING MOIETY TO AN AMINE CONTAINING MOIETY - The invention generally relates to methods of coupling a carbon containing moiety to an amine containing moiety. | 2021-11-25 |
| 20210363112 | POLYMORPHS OF PYRIMIDINE CYCLOHEXYL GLUCOCORTICOID RECEPTOR MODULATORS - The present invention provides crystalline forms of (E)-6-(4-Phenylcyclohexyl)-5-(3-trifluoromethylbenzyl)-1H-pyrimidine-2,4-dione, and methods of making and using the same. | 2021-11-25 |
| 20210363113 | INHIBITORS OF PLATELET FUNCTION AND METHODS FOR USE OF THE SAME - Disclosed herein are small molecule inhibitors of platelet function, and methods of using the small molecules to treat diseases, such as platelet hemostasis and thrombosis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the substituents are as described. | 2021-11-25 |
| 20210363114 | BIODERIVED EPOXIDE TRIAZINE NETWORKS AND METHODS OF MAKING THE SAME - The present disclosure relates to a method that includes a first reacting of a first molecule and formaldehyde and/or a paraformaldehyde to form a triazine-containing intermediate and a second reacting of the triazine-containing intermediate with a second molecule having an epoxy group to form a triazine-containing product. As described herein, the triazine-containing product may be bioderived and biodegradable. | 2021-11-25 |
| 20210363115 | CYCLOOLEFIN SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE - The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, and/or solvates, racemic mixtures, enantiomers, diasteromers, and tautomers thereof, wherein A, R | 2021-11-25 |
| 20210363116 | CRYSTAL FORM OF TAFAMIDIS AND PREPARATION METHOD THEREFOR AND USE THEREOF - The present disclosure relates to novel crystalline forms of tafamidis (hereinafter referred to as compound I) and processes for preparation thereof. The present disclosure also relates to pharmaceutical composition containing the novel crystalline forms, use of the novel crystalline forms for preparing drugs treating disease caused by transthyretin-mediated amyloidosis. The crystalline forms of tafamidis of the present disclosure have one or more improved properties compared with crystalline forms of prior art and have significant value for future drug optimization and development. | 2021-11-25 |
| 20210363117 | IMPROVED PROCESS FOR PREPARING OZANIMOD - The presented invention relates to a process for preparation of compound of formula (1) or a salt thereof (i.e.) ozanimod: (1). The invention also relates to intermediates used in the process. | 2021-11-25 |
| 20210363118 | PREPARATION METHOD FOR HIGH OPTICAL INDOXACARB INTERMEDIATE - A field of asymmetric catalytic synthesis, and in particular a preparation method for a high optical indoxacarb intermediate includes reacting 5-chloro-2-methoxycarbonyl-1-indanone ester (or indanone ester for short) with an oxidizing agent in the presence of a chiral Zr-salen polymer to obtain an indoxacarb intermediate (2S)-5-chloro-2,3-dihydro-2-hydroxy-1-oxo-1H-indole-2-carboxylic acid methyl ester. The yield is stabilized between 86% and 90%, and the S-enantiomer content is up to 99%. Such catalyst can replace catalysts such as cinchonine, and greatly increase the content of the effective S-enantiomer of the indoxacarb, so that the content of the hydroxyl intermediate S-enantiomer of the indoxacarb is raised from 75% to 99% or more. In addition, the chiral Zr-salen polymer catalyst is recycled without retreatment, and can be recycled at least 5 times or more, greatly reducing the production cost and laying a foundation for the industrial production of high quality indoxacarb. | 2021-11-25 |
| 20210363119 | PROTEASOME INHIBITORS - The disclosure provides proteasome inhibitors that can be used to halt cell division of rapidly dividing cells by preventing the degradation of cell cycle-regulating proteins, such as cyclins, cyclin-dependent kinase inhibitors, and p53. The proteasome inhibitor compounds can be used to inhibit the proliferation of cancer cells. | 2021-11-25 |
| 20210363120 | Biomass Conversion - Processes and reactor systems for biomass conversion are described. A continuous process for the conversion of carbohydrate-containing feed material into furanic compounds comprises a reaction step comprising subjecting said feed material to reaction conditions in a reaction medium comprising two immiscible liquid phases, including a reactive phase and an extractive phase, and a Brønsted acid as catalyst, wherein the reaction medium comprises a solid component comprising at least a part of a carbohydrate-containing fraction of said feed material. | 2021-11-25 |
| 20210363121 | NOTCH INHIBITORS FOR USE IN THE TREATMENT OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA - Compounds of formula (I) in the capacity of compounds with anti-tumor activity for the treatment of T-cell acute lymphoblastic leukemia (T-ALL). | 2021-11-25 |
| 20210363122 | COMPOUNDS FOR OPTICALLY ACTIVE DEVICES - The present invention relates to novel compounds, particularly to compounds comprising a photoactive unit, said novel compounds being particularly suitable for ophthalmic devices as well as to ophthalmic devices comprising such compounds. | 2021-11-25 |
| 20210363123 | SLC26A3 INHIBITORS AND USE THEREOF - Provided herein are inhibitors of SLC26A3, which is an anion (CV, HCO | 2021-11-25 |
| 20210363124 | HETEROCYCLYL POLYMETHINE IR CHROMOPHORES - The present disclosure provides NIR- and SWIR-active small molecule polymethine dyes with improved properties for use in optical imaging, photothermal therapy, and photodynamic therapy. | 2021-11-25 |
| 20210363125 | METHODS AND RELATED TOOLS FOR CBD CONVERSION TO THC - The present invention is directed to methods of producing THC from CBD utilizing non-harsh methodology and resulting in substantially increased yields, as well as devices built upon these novel methods. The methods and devices are material efficient, and in certain embodiments, solvent-free. In particular, in certain embodiments, these methods and related devices are suitable for commercial production of THC from CBD. Furthermore, in certain embodiments, the present invention provides methods of producing THC from CBD in manner that affords tunability to select the ratio of THC-8 to THC-9. | 2021-11-25 |
| 20210363126 | PROCESS FOR THE PREPARATION OF PIPERINE - The present application relates to a process for the preparation of piperine of high purity having low concentrations of isomeric impurities. | 2021-11-25 |
| 20210363127 | PROCESS FOR THE PREPARATION OF 2,2-DIFLUORO-1,3-BENZODIOXOLE AND INTERMEDIATES THEREOF - A process for preparing 2,2-difluoro-1,3-benzodioxole is provided that comprises a step of reacting 1,3-benzodioxole with chlorine in benzotrifluoride in the presence of a radical initiator. Additional processes are provided for preparing 2,2-dichloro-1,3-benzodioxole, which is used as an intermediate in preparation of 2,2-difluoro-1,3-benzodioxole. | 2021-11-25 |
| 20210363128 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 - Binding of the transcriptional co-activator, YAP1, to the transcription factor Oct4, induces Sox2, which is a transcription actor necessary for the self-renewal of stem-like cells from non-small cell lung cancer. The WW domain of YAP1 binds to the PPxY motif of Oct4 to induce Sox2. Delivering a peptide corresponding to the WW domain could prevent the induction of Sox2 and sternness. Similarly, peptides and mimetics of the PPxY motif would be able to inhibit sternness. Disclosed are compounds that affect el the Yap1:Oct4 interaction. | 2021-11-25 |
| 20210363129 | PREPARATION METHOD FOR EFINACONAZOLE - The present invention provides a preparation method for Efinaconazole, comprising the following steps: in the presence of a bromide and a base, subjecting (2R,3S)-2-(2,4-difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazole-1-yl)methyl]oxirane and an inorganic acid salt of 4-methylenepiperidine to a ring-opening addition reaction in a reaction solvent, to obtain Efinaconazole. The preparation method for Efinaconazole in the present invention has mild reaction conditions, high product yield, high purity, and low production costs, and is suitable for industrial production. | 2021-11-25 |
| 20210363130 | HETEROCYCLIC COMPOUND - Provided is a compound that may have a superior CDK12 inhibitory action and is expected to be useful as a prophylactic or therapeutic drug for cancer and the like. A compound represented by the following formula (I): | 2021-11-25 |
| 20210363131 | Antifibrotic Compounds And Related Methods - This discloses that compounds of Formula 1 have antifibrotic properties. In particular, this discloses a pharmaceutical composition including one or more compounds of Formula 1 and methods of using compounds of Formula 1 in fibrosis treatment and inhibiting type 1 collagen synthesis. | 2021-11-25 |
| 20210363132 | NOVEL COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING THE SAME - Provided is a compound of Chemical Formula 1: | 2021-11-25 |
| 20210363133 | PLURALITY OF HOST MATERIALS AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME - The present disclosure relates to a plurality of host materials comprising at least one first host compound represented by formula 1 and at least one second host compound represented by formula 2 and an organic electroluminescent device comprising the same. By comprising the host materials according to the present disclosure, an organic electroluminescent device having low driving voltage and/or high luminous efficiency and/or long lifespan can be provided. | 2021-11-25 |
| 20210363134 | NOVEL ANTHRANILAMIDES, THEIR USE AS INSECTICIDE AND PROCESSES FOR PREPARING THE SAME - The present invention relates to novel anthranilamides of Formula I, | 2021-11-25 |
| 20210363135 | COMPOUND OF 3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE-BASED BISOXAZOLINE LIGAND, INTERMEDIATE THEREOF, PREPARATION METHOD THEREOF AND USE THEREOF - Provided are a compound of 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-based bisoxazoline ligand, an intermediate, a preparation method and uses thereof. The compound of bisoxazoline ligand is a compound having a structure represented by formula I, or an enantiomer, a raceme, or diastereomer thereof. The bisoxazoline ligand can be prepared via a preparation scheme in which the cheap and easily available 6,6′-dihydroxyl-3,3,3′,3′-tetramethyl-1,1′-spirobiindane is used as a starting raw material and the compound represented by formula II serves as the key intermediate through a series of reactions. The new bisoxazoline ligand developed by the present application can be used in catalytic organic reaction, in particular as a chiral bisoxazoline ligand that is widely used in many asymmetric catalytic reactions of metal catalysis, and thus it has economic practicability and industrial application prospect. | 2021-11-25 |
| 20210363136 | MODULATORS OF THE INTEGRATED STRESS PATHWAY - Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions. | 2021-11-25 |
| 20210363137 | HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS - Disclosed are compounds of Formula (I′), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections. | 2021-11-25 |
| 20210363138 | SET8 LYSINE METHYLTRANSFERASE INHIBITOR AND PREPARATION METHOD AND APPLICATION THEREOF - The present invention provides an SET8 lysine methyltransferase inhibitor and a preparation method and application thereof. The structural formula of the inhibitor is as follows: | 2021-11-25 |
| 20210363139 | CXCR4 INHIBITORS AND USES THEREOF - The present invention provides compounds, compositions thereof, and methods of using the same. | 2021-11-25 |
| 20210363140 | COMPOUNDS USEFUL FOR INHIBITING RET KINASE - Provided herein are RET kinase inhibitors according to the formula: | 2021-11-25 |
| 20210363141 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE - Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (MAT) act to improve the disease state or condition. Further provided are compositions comprising the compounds. Further provided are methods for treating diseases or conditions, the methods comprising administering compounds according to the invention. One such disease may be glaucoma for which, among other beneficial effects, a marked reduction in intraocular pressure (IOP) may be achieved. | 2021-11-25 |
| 20210363142 | AGONISTS OF THE APELIN RECEPTOR AND METHODS OF USE THEREOF - Provided herein are small molecule agonists of the apelin receptor for the treatment of disease. The compounds disclosed herein are useful for the treatment of a range of cardiovascular, renal and metabolic conditions. The present invention is based on the seminal discovery of a series of potent small molecule agonists of the apelin receptor, which are useful for the treatment of diseases including heart failure, chronic kidney disease, hypertension, and metabolic disorders such as insulin resistance/diabetes and obesity. The compounds disclosed herein are highly specific for the apelin receptor versus the angiotensin II receptor (ATI). | 2021-11-25 |
| 20210363143 | PYRIDO-IMIDAZO RIFAMYCINS - The present invention relates to novel pyrido-imidazo rifamycins, characterized by a highly selective antibacterial activity and low absorption by oral route. | 2021-11-25 |
| 20210363144 | PYRROLO(PYRAZOLO)PYRIMIDINE DERIVATIVE AS LRRK2 INHIBITOR - The present invention relates to a pyrrolo(pyrazolo)pyrimidine derivative having efficacy as an LRRK2 inhibitor, a preparation method therefor, and a pharmaceutical composition for preventing or treating degenerative brain diseases, containing the same. | 2021-11-25 |
| 20210363145 | NOVEL MODULATORS OF THE SIGMA-2 RECEPTOR AND THEIR METHOD OF USE - Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of sigma-2 receptor activity. | 2021-11-25 |
| 20210363146 | TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE - Bivalent compounds, compositions comprising one or more of the bivalent compounds, and methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof are provided. Methods for identifying such bivalent compounds are provided, either. | 2021-11-25 |
| 20210363147 | NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS - Invented are compounds of formula I | 2021-11-25 |
