| 47th week of 2021 patent applcation highlights part 10 |
| Patent application number | Title | Published |
|---|
| 20210361747 | RECOMBINANT THROMBOMODULIN DOMAIN 1 FOR USE IN TREATING EYE DISEASES ASSOCIATED WITH PATHOLOGICAL OCULAR ANGIOGENESIS - The present application relates to dual anti-angiogenic and anti-inflammatory effects of recombinant thrombomodulin domain 1 (TMD1). Specifically, an isolated recombinant polypeptide comprising an amino acid sequence that is at least 80% identical to TMD1 for use in treating an eye disease and/or an eye disorder associated with pathological ocular angiogenesis (POA) in a subject in need thereof is disclosed. The length of the recombinant polypeptide is no more than 200 amino acid residues. The eye disease and/or the eye disorder may be at least one selected from the group consisting of retinopathy of prematurity, diabetic retinopathy, and age-related macular degeneration. Use of TMD1 in the manufacture of a medicament for treating an eye disease and/or an eye disorder associated with vascular endothelial growth factor (VEGF)-induced ocular angiogenesis and/or hypoxia-inducible factor-1α (HIF-1α)-VEGF pathway is also disclosed. | 2021-11-25 |
| 20210361748 | PHARMACEUTICAL OR FOOD SUPPLEMENT PREPARATION BASED ON ALPHA-LACTALBUMIN - Pharmaceutical or food supplement preparation including alpha-lactalbumin and at least one short-chain fatty acid (SCFA) or a precursor or derivative thereof for use in the treatment of disorders of the central nervous system; the SCFA or its precursor or derivative may be contained in at least one first dosage unit together with a carrier acceptable from the pharmaceutical or food standpoint and the alpha-lactalbumin in at least one second dosage unit together with a carrier acceptable from the pharmaceutical or food standpoint, and said dosage units may be distinct units intended for simultaneous or separate administration or the preparation may consist of a pharmaceutical or food supplement composition comprising the at least one short-chain fatty acid or a precursor or derivative thereof and alpha-lactalbumin together with a carrier acceptable from the pharmaceutical or food standpoint. | 2021-11-25 |
| 20210361749 | SHEAR-THINNING COMPOSITIONS AS AN INTRAVASCULAR EMBOLIC AGENT - This disclosure relates to methods of using shear-thinning compositions in the treatment of a vascular disorders, cancers, infections, abscesses, and fistulas. | 2021-11-25 |
| 20210361750 | Anti-Viral Lactoferrin Facemask - A breathable biological face covering comprising a fabric material and an anti-pathogen substance on the fabric material. The anti-pathogen substance comprises a lactoferrin protein. The amount of lactoferrin protein on the fabric material may be in the range of 0.6-1.5 grams/m | 2021-11-25 |
| 20210361751 | Enhancing Health in Mammals Using Telomerase Reverse Transcriptase Gene Therapy - Methods of treating an age-related disorder in a subject are provided. Aspects of the methods include administering to the subject a nucleic acid vector including a coding sequence for telomerase reverse transcriptase (TERT) and/or telomerase RNA (TR). Gene therapy methods are also provided. Aspects of the invention further include compositions, e.g., nuclcic acid vectors and kits, etc., that find use in methods of the invention. | 2021-11-25 |
| 20210361752 | Reducing or Inhibiting Ocular Damage by Hyaluronidase Administration - The present disclosure discloses compositions comprising a hyaluronidase, devices comprising such compositions, as well as methods and uses employing such compositions and devices to reduce or eliminate a hyaluronic acid-induced blockage of one or more blood vessels supplying an eye of an individual; methods and uses for employing such compositions and devices to reduce or inhibit a vascular occlusion in an eye of an individual; and methods and uses for employing such compositions and devices to reduce or inhibit a hyaluronic acid-induced loss of vision of an individual. | 2021-11-25 |
| 20210361753 | CYCLOPHILIN 40 FOR REDUCTION OF NEUROTOXIC FIBRILS AND TREATMENT OF NEURODEGENERATIVE DISEASES - The present invention concerns the use of peptidyl-prolyl isomerase cyclophilin 40 (CyP40) for reduction of neurotoxic fibrils and treatment and prevention of neurodegenerative diseases associated with amyloid fibril aggregation. Aspects of the invention include compositions, methods, dosage forms, and kits for treating or preventing a neurodegenerative disease or condition associated with amyloid fibril aggregation in a human or animal subject, and for disaggregating neurofibrillary aggregates in vitro or in vivo, using CyP40, or a biologically active fragment thereof. | 2021-11-25 |
| 20210361754 | METHOD OF PROVIDING PATIENT SPECIFIC IMMUNE RESPONSE IN AMYLOIDOSES AND PROTEIN AGGREGATION DISORDERS - A treatment of Alzheimer's disease and other disorders involving protein misfolding or aggregation is provided by enhancing or sustaining an antibody response against predominantly directed against pathological protein aggregates or neo-epitopes present on pathogenic forms of said protein or protein complex. Furthermore, therapeutic methods are described, wherein ex vivo stimulated antigen-selected peripheral blood lymphocytes are regrafted into the cognate donor. | 2021-11-25 |
| 20210361755 | TUMOR-SPECIFIC NEOANTIGENS AND METHODS OF USING THE SAME - The disclosure relates to methods of manufacturing individualized vaccines that comprise nucleic acid molecules that encode one or more neoantigens specific for antigens that are expressed by a tumor in a subject. Compositions comprising coding regions encoding neoantigens organized in a pattern of nucleic acid sequences are also disclosed as well as methods of immunizing a subject using the same. | 2021-11-25 |
| 20210361756 | PERIODONTITIS VACCINE AND RELATED COMPOSITIONS AND METHODS OF USE - An immunogenic composition, a periodontal vaccine formulation containing the immunogenic composition, and methods for treating or preventing periodontal disease are provided, where the methods involves administering an immunologically effective amount of the composition or vaccine formulation to a subject. The immunogenic composition contains at least one polypeptide that comprises: an Mfa1 antigen sequence that is substantially homologous to an immunogenic amino acid sequence from an Mfa1 fimbrilin protein of a | 2021-11-25 |
| 20210361757 | STREPTOCOCCAL VACCINE FORMULATIONS AND USES THEREOF - The present invention relates to streptococcal vaccine formulations and their use in generating immunity against streptococcal infection. | 2021-11-25 |
| 20210361758 | STREPTOCOCCAL VACCINES AND METHODS FOR USE - The present invention relates to streptococcal vaccine formulations and their use in generating immunity against streptococcal infection. | 2021-11-25 |
| 20210361759 | Vaccine for Prophylaxis or Treatment of an Allergen-Driven Airway Pathology - The present invention relates to a live attenuated | 2021-11-25 |
| 20210361760 | MHC CLASS I ASSOCIATED PEPTIDES FOR PREVENTION AND TREATMENT OF MULTIPLE FLAVI VIRUS - The invention provides a vaccine composition comprising a flavi peptide comprising one or more CD8+ T cell epitopes. | 2021-11-25 |
| 20210361761 | NOVEL YELLOW FEVER NUCLEIC ACID MOLECULES FOR VACCINATION - The present invention is directed to an artificial nucleic acid, particularly to an artificial RNA suitable for use in treatment and/or prophylaxis of an infection with yellow fewer vims (YFV) or a disorder related to such an infection. The invention further concerns a method of treating or preventing a disorder or a disease, first and second medical uses of the artificial RNA, compositions and vaccines. Further, the invention is directed to a kit, particularly to a kit of parts, comprising the artificial RNA, compositions and vaccines. | 2021-11-25 |
| 20210361762 | METHOD OF PURIFYING VIRUS-LIKE-PARTICLES - A method of producing purified FMDV VLPs, comprising contacting cells containing FMDV VLPs with a lysis buffer and allowing the cells to lyse, the lysis buffer comprising 10-20 mM Tris-HCl, 150-200 mM NaCl, 3 mM MgCl | 2021-11-25 |
| 20210361763 | MULTIVALENT LIVE INFLUENZA VACCINE PLATFORM USING RECOMBINANT ADENOVIRUS - The present invention relates to a multivalent live influenza vaccine platform using a recombinant adenovirus. The present invention is a live attenuated vaccine platform using a recombinant virus and it is easy to inoculate because it is infected with the respiratory tract like influenza virus and exhibits a vaccine action and it is a multivalent vaccine which combines two types into one and it is a highly novel vaccine that does not need to mix viruses compared to vaccines using multiple combinations of one vaccine. The present invention is the first vaccine in which a gene obtained by fusion of two influenza antigen genes into one gene is incorporated into a recombinant virus. Instead of using the entire HA gene of influenza, but using a structurally independent HA1 gene, which is about half of the total HA gene, several types of HA genes could be fused into one. When the recombinant virus was inoculated into mice by nasal inhalation, it was confirmed that it is an effective vaccine in which the vaccine effect is induced by two inoculations, and the vaccine platform of the present invention is expected to be useful for the development of a vaccine for human influenza infection. | 2021-11-25 |
| 20210361764 | POLYMERIC CARRIER CARGO COMPLEX FOR USE AS AN IMMUNOSTIMULATING AGENT OR AS AN ADJUVANT - The present invention is directed to a polymeric carrier cargo complex, comprising as a cargo at least one nucleic acid molecule and as a preferably non-toxic and non-immunogenic polymeric carrier disulfide-crosslinked cationic components for use as an immunostimulating agent or as an adjuvant, wherein the polymeric carrier cargo complex is administered in combination with at least one second nucleic acid molecule, which encodes a protein or peptide. The inventive polymeric carrier cargo complex administered in combination with the second nucleic acid molecule allows for both efficient transfection of nucleic acids into cells in vivo and in vitro and/or for induction of an innate and/or adaptive immune response, preferably dependent on the nucleic acid to be transported as a cargo and on the second nucleic acid molecule. The present invention also provides pharmaceutical compositions, particularly vaccines, comprising the inventive polymeric carrier cargo complex and the second nucleic acid molecule, as well as the use of the inventive polymeric carrier cargo complex and the second nucleic acid molecule for transfecting a cell, a tissue or an organism, as a medicament, for therapeutic purposes as disclosed herein, and/or as an immunostimulating agent or adjuvant, e.g. for eliciting an immune response for the treatment or prophylaxis of diseases as mentioned herein. Finally, the invention relates to kits containing the inventive polymeric carrier cargo complex and the second nucleic acid molecule, the inventive pharmaceutical composition and/or the inventive vaccine or any of its components in one or more parts of the kit. | 2021-11-25 |
| 20210361765 | CELL-ASSOCIATING IMMUNOLOGIC ADJUVANTS FOR TREATMENT ENHANCEMENT - This disclosure provides treatment kit that are capable of modulating the immune response. The treatment kit may also be used enhance the immunogenicity of antigens released from cell debris. Also provided are methods of using the treatment kit. | 2021-11-25 |
| 20210361766 | VACCINE COMPOSITIONS AND METHODS OF USE - The present disclosure provides vaccine compositions comprising at least one adjuvant and at least one antigen, wherein the adjuvant is a cationic lipid. The disclosure also provides methods of treating a disease in a mammal, methods of preventing a disease in a mammal, and methods of effecting antigen cross presentation to induce a humoral immune response and a cellular immune response in a mammal utilizing the vaccine compositions. Cross presentation of various antigens can be achieved by formulating the specific antigens with cationic lipids possessing adjuvant properties. | 2021-11-25 |
| 20210361767 | RESCUING CANCER PATIENTS FROM RESISTANCE TO TREATMENT WITH INHIBITORS OF PD-1/PD-L1 INTERACTIONS - Materials and methods for inhibiting sPD-L1 production to prevent downregulation of the immune system and enhance the use of inhibitors of PD-1/PD-L1 interaction are provided herein. The materials and methods can be used in the treatment of cancer, for example. | 2021-11-25 |
| 20210361768 | METHODS AND MATERIALS FOR ASSESSING AND TREATING CANCERS - This document provides methods and materials involved in for assessing and/or treating a mammal having a human epidermal growth factor receptor 2 (HER2)-positive cancer. For example, methods and materials for detecting the presence or absence of an adaptive immune signature and/or a molecular tumor infiltrating lymphocyte signature in a mammal having cancer, thereby identifying that the cancer is likely to respond to a particular cancer treatment, are provided. For example, methods and materials for treating a mammal identified as having a cancer likely to respond to a particular cancer treatment based, at least, in part on the presence or absence of an AIS and/or mTIL are provided. | 2021-11-25 |
| 20210361769 | DRUG REGIMEN FOR TREATMENT OF CEREBRAL ISCHEMIA - Treatment of subjects experiencing cerebral ischemia is improved when the treatment employs a thrombolytic and an inhibitor against vascular endothelial growth factor receptor signal transduction (VEGF-RST) at a reduced, low dosage compared to that used to treat cancer patients. The treatment is also improved to permit point-of-care use by formulating protein drugs for long term stability at room temperature, providing doses appropriate for the method, and by combining the therapeutic agents with a point-of-care diagnostic for blood brain barrier integrity. | 2021-11-25 |
| 20210361770 | INTRANASAL EPINEPHRINE FORMULATIONS AND METHODS FOR THE TREATMENT OF DISEASE - Drug products adapted for nasal delivery comprising formulations with epinephrine and devices comprising such formulations are provided. Methods of treating anaphylaxis with epinephrine products are also provided. | 2021-11-25 |
| 20210361771 | TERPENE COUPLING CONJUGATE - The subject matter of the present invention relates to the use of an optionally branched linear terpene having at most one C═C unsaturation for the production of conjugates provided with self-assembly properties, as well as a self-assembly agent of formula (I): | 2021-11-25 |
| 20210361772 | ENZYME AND RECEPTOR MODULATION - Covalent conjugation of an alpha amino acid ester to a modulator of the activity of a target intracellular enzyme or receptor, wherein the ester group of the conjugate is hydrolysable by one or more intracellular carboxylesterase enzymes to the corresponding acid, leads to accumulation of the carboxylic acid hydrolysis product in the cell and enables improved or more prolonged enzyme or receptor modulation relative to the unconjugated modulator. | 2021-11-25 |
| 20210361773 | COMPOUNDS AND METHODS FOR SELECTIVE PROTEOLYSIS OF GLUCOCORTICOID RECEPTORS - The present disclosure relates to steroidal glucocorticoid receptor (GR) ligands and related compositions that degrade the GR and/or modulate its activity that may be utilized as pharmaceuticals for the treatment of diseases including cancer. | 2021-11-25 |
| 20210361774 | DEGRADERS OF WILD-TYPE AND MUTANT FORMS OF LRRK2 - Disclosed are bifunctional compounds (degraders) that target LRKK | 2021-11-25 |
| 20210361775 | IMPROVED FVIII FUSION PROTEIN AND USE THEREOF - Disclosed are a coagulation factor VIII fusion protein which is conjugated with polyalkylene glycol and which has an extended cyclic half-life, a preparation method therefor and a use thereof, wherein the active moiety of the coagulation factor VIII is directly linked or indirectly linked by a peptide linker to a fusion partner, and the fusion protein is further conjugated to a polyalkylene glycol. The half-life is significantly increased compared to an FVIII fusion protein modified without polyalkylene glycol. | 2021-11-25 |
| 20210361776 | GLYPICAN 3 ANTIBODIES AND CONJUGATES THEREOF - The invention provides murine, chimeric, and humanized antibodies that specifically bind to GPC3 and conjugates thereof. | 2021-11-25 |
| 20210361777 | PHARMACEUTICAL PRODRUGS AND METHODS OF THEIR PREPARATION AND USE - The disclosure provides compounds of Formula (I), wherein X, Y, and Z are defined herein. The disclosure also provides particles comprising one or more compounds described herein, compositions comprising one or more compounds or particles described herein and a pharmaceutically acceptable carrier, and methods of treating a subject in need thereof comprising administering one or more compounds, particles, or compositions described herein to the subject. | 2021-11-25 |
| 20210361778 | ADENO-ASSOCIATED VIRUS COMPOSITIONS FOR IDS GENE TRANSFER AND METHODS OF USE THEREOF - Provided are adeno-associated virus (AAV) compositions that can restore IDS gene function in cells, and methods for using the these AAV compositions to treat disorders associated with reduction of IDS gene function (e.g., Hunter syndrome). Also provided are compositions, systems and methods for making the AAV compositions. | 2021-11-25 |
| 20210361779 | DELIVERY, USE AND THERAPEUTIC APPLICATIONS OF THE CRISPR-CAS SYSTEMS AND COMPOSITIONS FOR TARGETING DISORDERS AND DISEASES USING VIRAL COMPONENTS - The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition. | 2021-11-25 |
| 20210361780 | METHODS FOR TREATING AND DIAGNOSING BLINDING EYE DISEASES - This invention relates to, in part, methods and compositions that are useful for the diagnosis, treatment, or prevention of a blinding eye disease, including in the discovery of drugs that are efficacious against these diseases. Diseases include, for example, age related macular degeneration and reticular pseudodrusen disease, and the methods described herein include, for example, the method named delayed near infrared analysis (DNIRA). | 2021-11-25 |
| 20210361781 | COMPOUNDS HAVING RD TARGETING MOTIFS AND METHODS OF USE THEREOF - The present invention provides compounds that have motifs that target the compounds to cells that express integrins. In particular, the compounds have peptides with one or more RD motifs conjugated to an agent selected from an imaging agent and a targeting agent. The compounds may be used to detect, monitor and treat a variety of disorders mediated by integrins. | 2021-11-25 |
| 20210361782 | COMPLEX OF GADOLINIUM AND A CHELATING LIGAND DERIVED OF A DIASTEREOISOMERICALLY ENRICHED PCTA AND SYNTHESIS METHOD - The present invention relates to a complex of formula (II) constituted of at least 80% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae: | 2021-11-25 |
| 20210361783 | METALLOHYDROPORPHYRINS FOR PHOTOACOUSTIC IMAGING - Provided are photoacoustic imaging contrast agents that include at least one radiation-absorbing component comprising a copper-complexed and/or manganese-complexed chlorin and/or bacteriochlorin and/or a derivative thereof, or a combination thereof. Also provided are methods for using the disclosed photoacoustic imaging contrast agents either singly or in combination for generating an image of a volume, optionally a subject or a body part, cell, tissue, or organ thereof. Further provided are compositions and methods for multiplex photoacoustic imaging of a volume, optionally a subject or a body part, cell, tissue, or organ thereof using photoacoustic imaging contrast agents that include a plurality of the presently disclosed copper-complexed and/or manganese-complexed chlorins and/or bacteriochlorins and/or derivatives thereof simultaneously. | 2021-11-25 |
| 20210361784 | IMAGING AGENTS AND METHODS OF USE - An imaging agent and a method of its use for imaging a necrosis in a tissue of a subject. The imaging method may be positron emission tomography (PET). In at least one embodiment the imaging agent comprises 2-deoxy-2-[ | 2021-11-25 |
| 20210361785 | CONTINUOUS PROCESS FOR THE PREPARATION OF 2-(1H-IMIDAZOL-4-YL) ETHANAMINE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF - The present invention relates to stable pharmaceutical compositions of sulfur colloid, which advantageously provide a high radiochemical purity to | 2021-11-25 |
| 20210361786 | MATERIAL WITH SUPERCAPACITANCE MODIFIED SURFACE AND PREPARATION METHOD AND APPLICATION THEREOF - Disclosed are a material with supercapacitance modified surface and a preparation method and application thereof. Specifically, the present disclosure introduces a material having a controllably supercapacitive surface. The surface is chargeable, the full-charged modified surface can interact with bacteria disturbing the electron transfer of respiratory chain of bacteria and inhibiting the growth and reproduction of bacteria in a short-term. The antibacterial rate can be improved by cyclically charging-discharging without losing capacitance, and prevent formation of biofilm of bacteria. The antibacterial system can quantitatively control the antibacterial process without affecting the biocompatibility of the material, and has the advantages of environmental protection and controllability. | 2021-11-25 |
| 20210361787 | Methods and Systems for the Sterilization of Endoscopes - A method and device for high-pressure, high-temperature steam sterilization of endoscopes includes pressure resistant fittings to attach a steam generator to the ports of an endoscope. The method and device allows for high-pressure, high-temperature steam to circulate throughout the endoscope, exposing various surfaces to steam for sterilization. The method and device also allows for high-pressure, high-temperature steam to circulate selectively through the channels of the endoscope, selectively sterilizing the channels and allowing for use of this method with current high-level disinfection methods. The method and device also allows for movement of the scope elevator channel during the sterilization process, allowing for steam to reach the crevices around the elevator and other moving parts of an endoscope. | 2021-11-25 |
| 20210361788 | APPARATUS AND METHOD FOR STERILIZING FINGERPRINT RECOGNITION AREA - An apparatus for sterilizing a fingerprint recognition area, the apparatus includes at least one finger contact unit for obtaining a fingerprint image on which a body of a user is contacted, a sterilizing light emitting unit configured to emit the sterilizing light onto the at least one finger contact unit for obtaining the fingerprint image, at least one optical sensing unit configured to sense the sterilizing light emitted onto the at least one finger contact unit for obtaining the fingerprint image and a control unit configured to determine an ON timing of the sterilizing light emitting unit after performing user authentication for the user, and determine an OFF timing of the sterilizing light emitting unit based on a result of comparing an accumulated value of the calculated energy of the sterilizing light with a predetermined reference energy. | 2021-11-25 |
| 20210361789 | PROCESS FOR PROVIDING ANTIMICROBIAL TREATMENT TO NON-WOVEN FABRICS - An apparatus and process for disinfecting, and, optionally, sterilizing, fibers and non-woven materials produced from the fibers is disclosed, as well as processes for converting fibers into disinfected and/or sterilized non-woven materials. The process involves contacting the fibers and/or non-woven materials with high temperature steam, and then with UV light, which is preferably UV-C light, or another disinfectant process, such as ozone treatment. The process can also involve process steps such as blending fibers, applying fibers to an air card, subjecting the fibers to one or more carding steps, subjecting the carded fibers to non-woven process steps, and chemically treating the fibers and/or non-woven materials. The resulting non-woven materials can be used, for example, in personal care, baby care (including baby wipes), cosmetic applications, household cleaning, automotive, industrial cleaning applications, industrial uses, and the like. | 2021-11-25 |
| 20210361790 | SYSTEM AND METHOD FOR DISINFECTING FUEL TANKS - A fuel tank disinfection system, including one or more ultraviolet (UV) light emitters disposed within a fuel tank and configured to irradiate one or more water collecting areas within the fuel tank with UV light; and one or more UV light sensors disposed within the fuel tank and in proximity to the one or more water collecting areas and configured to measure the UV light irradiated on the one or more water collecting areas. | 2021-11-25 |
| 20210361791 | AIRCRAFT SANITIZATION SYSTEMS AND DEVICES - An aircraft sanitization system is disclosed. The aircraft sanitization system includes a frame. The aircraft sanitization system further includes a tray operatively coupled to at least first two corners of the frame and is rotatable about a pivot axis. The tray is configured to be in one of a locked state and an unlocked state based on rotation about the pivot axis. In the unlocked state the tray is at an angle greater than zero with respect to the frame and in the locked state the tray is at an angle equal to zero with respect to the frame. The aircraft sanitization system further includes a set of Ultraviolet (UV) Light Emitting Diodes (LEDs) attached on an exposed surface of the frame, wherein the set of UV LEDs is configured to sanitize the tray when the tray is in the locked state. | 2021-11-25 |
| 20210361792 | UV EMITTER MODULE AND USE THEREOF - UV lamp modules for the ultraviolet irradiation of a substrate. The modules include multiple low-pressure mercury lamps, each having a longitudinal axis, located in a waterproof housing having a bottom, a top and a beam exit opening in the bottom which is closed by a beam exit window. To maintain hygiene, homogeneity and compactness, a first airflow zone for the supply of cooling air and a second, separate airflow zone for the discharge of heated cooling air are formed iii the housing. Viewed in a cross-section through the housing perpendicular to the longitudinal axes of the lamps and in a viewing direction from the bottom to the top, the beam exit window, the lamps and the airflow zones are arranged one after the other. The first airflow zone comprises an air supply duct which is equipped with at least one air-guiding mechanism for supplying cooling air to the lamps. | 2021-11-25 |
| 20210361793 | PORTABLE SANITIZING SYSTEMS AND METHODS WITH RANGE GUIDANCE - A sanitizing head includes a housing and multiple range light sources. The housing retains an ultraviolet (UV) lamp, and UV light emitted from the UV lamp exits through a front end of the housing. The range light sources are secured to the housing and arranged in one or more pairs. The range light sources in each pair of the one or more pairs are oriented relative to each other to emit respective light beams that converge at a predetermined distance in front of the UV lamp. | 2021-11-25 |
| 20210361794 | Portable Infection Prevention Systems - A handheld disinfection device includes a housing, at least one reflector within the housing, at least one ultraviolet emitter mounted in each reflector, a window that is substantially transparent to ultraviolet light, adjacent to each reflector, through which ultraviolet light emitted by each ultraviolet emitter travels, and at least one position sensor associated with the housing. Another exemplary handheld disinfection device includes a housing, a disinfectant applicator associated with the housing, and at least one position sensor associated with the housing. | 2021-11-25 |
| 20210361795 | GERMICIDAL HANDLES - A germicidal system includes a handle for opening a door or compartment. An ultra-violet illuminator is mounted proximate the handle for irradiating a surface of the handle to reduce pathogens from the handle between uses. The illuminator can include at least one LED that emits in ultra-violet wavelengths. A sensor can be included proximate the handle. A controller can be operatively connected to the sensor and to the illuminator. The controller can be configured to activate the illuminator based on detection of a user by the sensor. The controller can be configured to activate the illuminator for a predetermined amount of time for each use of the handle. | 2021-11-25 |
| 20210361796 | SANITIZING SYSTEM FOR SANITIZING DEVICES AND METHOD THEREFOR - A sanitizing system for sanitizing multiple shared fungible handheld devices, the system including a sanitizing station including a closure configured to hold enclosed therein at least one of the multiple shared fungible handheld devices, and a radiation source of UV-C radiation coupled to the closure and disposed to irradiate surface(s) of the at least one of multiple shared fungible handheld devices held in the closure effecting sanitization of unsanitary surface(s) of the at least one of the multiple shared fungible handheld devices to a predetermined sanitization characteristic that determines the surface(s) being sanitary, and a sensor configured so as to measure a dosage of radiation received by the unsanitary surface(s) of the at least one of multiple shared fungible handheld devices, via the radiation source, and signal receipt of efficacious measured dose of radiation sanitization to each of the at least one of the multiple shared fungible handheld devices. | 2021-11-25 |
| 20210361797 | SYSTEMS AND METHODS FOR PATHOGEN PROLIFERATION REDUCTION - A system for reducing pathogen proliferation on a device includes a waveguide disposed on a body of the device and including a first layer of transparent material having a first refractive index greater than a second refractive index of the body of the device and a third refractive index of an environment in contact with an outer surface of the first layer. A first light source is configured to emit light having a first range of wavelengths into the first layer. The light is substantially confined within the waveguide by total internal reflection. Total internal reflection is frustrated at points of contact between the pathogens or a medium in which the pathogens are suspended and an outer surface of the waveguide, thereby scattering a portion of the light out of the waveguide and into the pathogens and, thereby, reducing proliferation of the pathogens. Related methods are also provided. | 2021-11-25 |
| 20210361798 | METHOD AND SYSTEM FOR MASK DISINFECTION - A disinfection system includes a mask chamber and a cassette trolley rail mounted to the mask chamber. The system also includes a mask cassette configured to hold one or more masks and configured to mount to the cassette trolley rail such that the mask cassette translates along the cassette trolley rail. The system also includes a first array of lamps mounted to a first lamp mount within the mask chamber, where the first array of lamps is positioned to emit radiation toward a first side of the mask cassette. The system further includes a second array of lamps mounted to a second lamp mount within the mask chamber, where the second array of lamps is positioned to emit radiation toward a second side of the mask cassette that is opposite the first side of the mask cassette. | 2021-11-25 |
| 20210361799 | TROLLEY WITH UV SANITATION - A trolley assembly includes a trolley housing defining an internal cavity. The assembly includes at least one ultra-violet (UV) illumination system contained within the internal cavity in a stowed position. The UV illumination system configured and adapted to extend outward from the internal cavity in a deployed position. The trolley assembly includes a battery in electrical communication with the at least one UV illumination system. | 2021-11-25 |
| 20210361800 | ANTIVIRAL AIRCRAFT INTERIOR COMPONENTS AND METHOD OF ANTIVIRAL PROTECTION - An antiviral system comprises, an interior space, and an ultra-violet (UV) illuminator system fixedly mounted within the interior space for illumination of surfaces within the interior space for destruction of pathogens on the surfaces. A plurality of seats can be arranged within the interior space such that the UV illuminator system is configured to illuminate full or partial surfaces of individual seats of the plurality of seats. | 2021-11-25 |
| 20210361801 | LOOSE OBJECTS AND PROTECTIVE GEAR DISINFECTION GALLEY INSERT - A galley insert assembly for an aircraft galley comprises an insert body including a plurality of insert walls defining an interior space therein. The insert walls are configured to interface with a galley bay of an aircraft with the insert body inserted into the galley bay. A disinfection system is included within the interior space and a door is operatively connected to the insert walls. | 2021-11-25 |
| 20210361802 | FLUID STERILIZER AND ASSOCIATED CONNECTING DEVICE - A sterilizer may include: a first pipe having an inner wall with a light reflecting property; a second pipe disposed in the first pipe so as to pass fluid therethrough and formed of a light transmitting material; and a plurality of UV LEDs arranged on the inner wall of the first pipe and configured to irradiate sterilization UV light onto the fluid. | 2021-11-25 |
| 20210361803 | HEARING AID DRYER AND DISINFECTION KIT WITH UV-REFLECTIVE DRYING TRAY - A portable dryer and disinfection device includes a container having an interior for receiving one or more electronic components for drying and disinfection. A lid is configured to be removably secured to an upper portion of the container. An ultraviolet light source is attached to a bottom portion of the lid, wherein ultraviolet light generated by the ultraviolet light source is directed into the interior of the container below the lid. A power source is disposed in the lid for providing electrical power to the ultraviolet light source. A tray is disposed within the interior of the container on which the one or more electronic components are placed for drying and disinfection. The tray includes holes that provide air flow communication through the removable tray. A removable desiccant holder is disposed at least partially within the interior of the container below the tray. | 2021-11-25 |
| 20210361804 | METHOD OF MANUFACTURING A FRESHENING COMPOSITIONS COMPRISING PARTICLES SUSPENDED IN A STRUCTURED AQUEOUS COMPOSITION - A method of manufacturing an aqueous freshening composition having a plurality of particles suspended by a structurant system is provided. The method includes the steps of: mixing an aqueous carrier and at least 80 wt. % of ion-forming water-soluble ingredients of the freshening composition to form an aqueous premix; subsequently mixing a first polysaccharide into the aqueous premix; mixing a second polysaccharide into the aqueous premix after mixing the first polysaccharide into the aqueous premix to form a structured aqueous composition; and dispersing a plurality of particles into the structured aqueous composition to form the freshening composition. | 2021-11-25 |
| 20210361805 | ANTI-ODOR COMPOSITIONS, STRUCTURES HAVING ANTI-ODOR CHARACTERISTICS, METHODS OF MAKING THE ANTI-ODOR COMPOSITIONS AND THE STRUCTURES - One or more aspects of the present disclosure are directed to aqueous solutions that can be used to make substrates such as an article that can inhibit or limit one or more sources of odor. In an aspect, the aqueous solution can include one or more components, where one of the components is an inhibiting agent that can function to inhibit or limit the sources of odor in an article such as a textile. | 2021-11-25 |
| 20210361806 | SYSTEMS AND METHODS FOR DISINFECTING FOOD PACKAGING - Disclosed is a method for disinfecting packaging. In certain aspects, the method comprises placing the packaging in a contacting chamber and directly contacting the packaging with gaseous ozone for a time interval, wherein the time interval is sufficient to substantially reduce pathogens on the packaging. In certain embodiments, the time interval is from about 3 seconds to about 30 seconds. In certain aspects, the gaseous ozone is comprised of from about 6% to about 12% ozone and the time interval is sufficient to substantially reduce pathogens on the packaging. | 2021-11-25 |
| 20210361807 | ULTRAVIOLET EMITTER FOR SANITATION OF AEROSOLS - A sanitation system for use in an application where contaminated aerosols are exhausted by a person includes at least one light source selectively operable to emit a light having a wavelength capable of neutralizing particles and that does not penetrate human skin. The sanitation system additionally includes a mounting system operable to mount said at least one light source. The mounting system is configured to direct the light emitted from the at least one light source toward the person such that the particles are neutralized as the particles are exhausted by the person. | 2021-11-25 |
| 20210361808 | Disinfecting Enclosure System - A system for disinfecting; the system includes an enclosure, a first disinfecting assembly, a second disinfecting assembly and a power source. The first disinfecting assembly utilizes ultraviolet light and the second disinfecting assembly utilizes a disinfecting solution. The system is useful for disinfecting a body of an individual, their clothing, accessories, etc. upon entry to a building, or upon exit of the building. | 2021-11-25 |
| 20210361809 | INTELLIGENT DISINFECTION CARPET, AND CARPET DISINFECTION METHOD AND DEVICE - The present disclosure relates to an intelligent disinfection carpet, a carpet disinfection method, and a carpet disinfection device. The intelligent disinfection carpet can include a control module and a plurality of mutually independent disinfection elements. The control module is communicatively connected with the disinfection elements for controlling some or all of the plurality of mutually independent disinfection elements to release disinfection media. | 2021-11-25 |
| 20210361810 | MODULAR AND CONFIGURABLE SANITIZATION SYSTEM - A modular and configurable sanitization system includes one or more panels and a processing module. The processing module is operable to obtain configuration data pertaining to one or more of: the one or more panels, one or more configurable sanitizing mechanisms of the one or more panels, and one or more sanitization subjects, determine one or more sanitization protocols based on the configuration data, generate one or more sanitizing mechanism configuration instructions to configure the one or more configurable sanitizing mechanisms based on the one or more sanitization protocols and in accordance with the one or more sanitization subjects, generate one or more panel configuration instructions to configure the one or more panels based on the one or more sanitization protocols and in accordance with the one or more sanitization subjects, and configure the one or more configurable sanitizing mechanisms and the one or more panels. | 2021-11-25 |
| 20210361811 | ELECTRONIC SCENTED CANDLE AND FRAGRANCE CONTAINER - An electronic scented candle is described that includes a movable flame-shaped component, a shell including an installation chamber, a fragrance container that is removably positioned inside the installation chamber and a scent chamber. An electric fan is positioned within the shell to drive the air into the scent chamber and a scent outlet coupled to the scent chamber to allow the fragrance material to leave the scent chamber and to reach an external environment of the electronic scented candle. The electronic candle also includes a receptacle for connecting a power cord on a bottom surface of the electronic candle. The bottom surface includes a plurality of protruding stands that provide a space to allow the power cord to be connected to the receptacle and be routed below the bottom surface. | 2021-11-25 |
| 20210361812 | Scent Glass Diffuser - A fragrance diffuser has a diffuser element connecting a first reservoir to a second reservoir. As a fragrant oil flows between the reservoirs, the diffuser element becomes saturated with oil and diffuses the fragrance or scent. The diffuser is self-contained, easy to interact with, without creating a mess. The diffuser is relaxing and pleasant to watch as it flows through from one end and drips to the other, releasing one small bubble at a time. It is refillable, transportable, and the intensity of the scent release can be controlled easily by saturating the wood more or less often. | 2021-11-25 |
| 20210361813 | WIRELESS ELECTROMECHANICAL DEVICE FOR CONTROLLED RELEASE OF FRAGRANCES AND SCENTS - An electromechanical emitter of fragrances/scents includes a blowpipe constructed in elastomeric material, which has an open edge layered by a latch valve and the other edge, closed, contains a magnet. In the internal side of the blowpipe, there is an absorber element with the fragrance or scent and an electric reel curly in its external side. When the reel receives alternated electric pulses, it generates a form of magnetic inductance shaping an alternated magnetic field attracting and repelling the magnet, making the blowpipe to enter into a frequency where a greater range of movement and greater volume of air in motion through the internal side of the system can be observed, enhancing the scent during the blowpipe vibration. | 2021-11-25 |
| 20210361814 | Disinfectant Fogger - This present invention relates to a novel disinfectant fogger device and a disinfecting solution contained therein for disinfecting or sanitizing an enclosed space. The disinfecting solution is intended to kill germs, bacteria, viruses and other harmful microbes. The disinfectant fogger device is comprised of an aerosol container, the disinfecting solution, and a lock top nozzle that is repositionable from a first position to a second position by depressing the nozzle and then twisting it in a select clockwise or counterclockwise direction. Once activated, the pressurized disinfecting solution is released into the air, thereby killing germs, bacteria, viruses and other harmful microbes from all surfaces in the enclosed space. | 2021-11-25 |
| 20210361815 | UV Sterilization Apparatus, System, and Method for Aircraft Air Systems - A sanitizing unit configured for use in an air distribution system of a passenger aircraft is disclosed. The sanitizing unit may include an input structure connected to a cabin air supply plenum, a UV reflective insert that defines an irradiation chamber, at least one ultraviolet (UV) light emitting diode (LED) positioned to provide UV radiation to an airflow within the irradiation chamber, a UV attenuator; and an output structure connected to at least one overhead passenger vent, wherein the at least one overhead passenger vent is configured to output a treated airflow. | 2021-11-25 |
| 20210361816 | ULTRAVIOLET DISINFECTION DEVICE AND USES THEREOF - The present invention provides a device for generating ultraviolet (UV) radiation whose wavelength is optimally tuned into the range of 240 to 290 nm, with peak wavelength in the range of 260 to 270 nm, which attains a Peak Germicidal Disinfection Effective Index of nearly 100%, superior to conventional UV lights and lamps. This device comprises a light-emitting diode (LED) matrix, a fan, an LED driver, a base and a motion sensor with programmable sensitivity and time delay. It may further comprise components for thermal protection and active air circulation. When operating, the device emits visible UVA radiation and blue light. With special considerations for user safety, the device effectively protects users from exposure to UV hazards and is safe to use. With the built-in thermal protection, this device may be used with either open or enclosed fixtures. | 2021-11-25 |
| 20210361817 | CABIN ISOLATION ASSEMBLIES - An isolation section assembly includes a section housing defining an interior space. The section housing includes a door with access to the interior space. The isolation section assembly includes an enclosure abutting the door. The airlock enclosure defines an interior airlock space. The interior airlock space is configured and adapted to be at a negative pressure relative to a cabin area. An air recirculation system in fluid communication with at least one of the interior space of the section housing or the interior airlock space. | 2021-11-25 |
| 20210361818 | Sterilization mask with UVC reflective chamber - The sterilization mask with UVC reflective chamber includes a chamber with reflective liner, through which inhaled and exhaled air passes. The reflective chamber is also referred to as a sterilization chamber. Using a reflective chamber ensures each photon of UVC light has a long life, thus dissipating slowly. Increasing the life of the UVC photons decreases the quantity of photons that must be created. Thus, less power is required to achieve the sterilization. Sterilization is defined as a 6-log reduction (99.9999%) of various microbes including viruses, bacteria, and spores. The reflective chamber is made reflective using an UVC internal reflective surface. This surface is preferably formed from ePTFE, or other equivalently UVC reflective material. | 2021-11-25 |
| 20210361819 | FAN FOR IMPROVING AIR QUALITY - A fan is for improving air quality, such as in an indoor environment. The fan includes a motor and a rotatable hub coupled to the motor. At least one fan blade includes a first end portion coupled to the rotatable hub and a second end portion radially distant from the rotatable hub. At least one ion generator is carried by the second end portion of the at least one fan blade, such as by a winglet associated therewith. A stationary tube passes through the rotatable hub including a conduit for transmitting power. A rotary coupling is also provided for transmitting power from the conduit to the at least one ion generator. | 2021-11-25 |
| 20210361820 | ANTIMICROBIAL COMPOSITION, DRESSING, DRESSING COMPONENTS, AND METHOD - An antimicrobial composition may comprise a surfactant. The antimicrobial composition may include about 30 μg/ml to about 1,000 μg/ml of the surfactant, by volume of the antimicrobial composition. The surfactant may comprise a docusate salt such as docusate sodium. The antimicrobial composition may comprise an antimicrobial agent. The antimicrobial composition may include from about 0.01% to about 10% of the antimicrobial agent, by weight of the antimicrobial composition. The antimicrobial agent may comprise polyhexanide (PHMB). In some embodiments, the antimicrobial composition may comprise a matrix-forming material. The antimicrobial composition may include at least 90% of the matrix-forming material, by weight of the antimicrobial composition. The matrix-forming material may comprise collagen, oxidized regenerated cellulose, alginate, carboxymethylcellulose, or combinations thereof. | 2021-11-25 |
| 20210361821 | MEDICAL DEVICE HAVING A PHOTOSENSITIZER AND RELATED METHODS - A medical device may include a body and a photosensitizer integrated with the body. The medical device may passively resist colonization of bacteria under ambient light. The medical device may also actively resist colonization of bacteria by releasing reactive oxidative species (ROS) in response to administration of a light dose in a range of 0.5 J/cm | 2021-11-25 |
| 20210361822 | FUNCTIONAL WOUND DRESSING - The invention relates to a functional wound dressing being able to detect and indicate the state of the wound, in particular with regard to infections for example caused by toxins produced by bacteria such | 2021-11-25 |
| 20210361823 | POLYMER PARTICLES - Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents. | 2021-11-25 |
| 20210361824 | MEDICAL SEALANT GLUE CAPABLE OF PROMOTING WOUND HEALING AND PREPARATION METHOD THEREOF - The disclosure provides a medical sealant glue capable of promoting wound healing and a preparation method thereof. The medical sealant glue is formed by covalent cross-linking of two components after being physically mixed by a mixing tool, wherein the first component is a nucleophilic component, and the second component is an electrophilic component. The medical sealant glue has a gelation time of 1-10 s, a swelling ratio of 0-100%, a bursting strength of 100-250 mmHg, and a degradation time of 0.5-300 days. The nucleophilic component of the medical sealant glue contains exosome or hyaluronic acid and chitosan, and thus the medical sealant glue not only has the effect of promoting wound healing, but also has antibacterial and anti-infection effects. | 2021-11-25 |
| 20210361825 | COMPOSITIONS AND METHODS FOR MACROPHAGE CONVERSION - One aspect of the invention provides a method of treating a chronic wound including administering to the wound at least one agent from a delivery system wherein the agent induces sequential conversion of a first population of wound macrophages in the wound to M2A macrophages and a second population of wound macrophages to M2C macrophages. The sequential conversion of the wound macrophages promotes tissue remodeling. | 2021-11-25 |
| 20210361826 | Biodegradable, Thermally Responsive Injectable Hydrogel for Treatment of Ischemic Cardiomyopathy - Provided are novel biocompatible copolymers, compositions comprising the copolymers, and methods of using the copolymers. The copolymers are non-toxic and typically have an LCST below 37° C. Compositions comprising the copolymers can be used for wound treatment, as a cellular growth matrix or niche and for injection into cardiac tissue to repair and mechanically support damaged tissue. The copolymers comprise numerous ester linkages so that the copolymers are erodible in situ. Degradation products of the copolymers are soluble and non-toxic. The copolymers can be amine-reactive so that they can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymers. | 2021-11-25 |
| 20210361827 | ELASTIC BIORESORBABLE ENCASEMENT FOR IMPLANTS - Disclosed herein are elastic, bioresorbable encasements for medical implants, methods for making the same and uses thereof. | 2021-11-25 |
| 20210361828 | INFUSED FIBERS - A method of making infused bone fibers employs the following steps: cutting or shaving whole bone into bone fibers, washing the bone fibers, demineralizing or decalcifying at least partially the whole bone or bone fibers and infusing the bone fibers with a supernatant of biologic material or a polyampholyte cryoprotectant or a combination of both to create infused bone fibers. The step of infusing includes exposing the bone fibers to a negative pressure or vacuum to draw the supernatant and/or the polyampholyte cryoprotectant into the bone fibers, or alternatively, exposing the demineralized whole bone to a positive pressure to drive the supernatant and/or the polyampholyte cryoprotectant into the bone. The resultant method creates an infused bone grafting composition having bone fibers taken from whole bone, demineralized or decalcified at least partially and infused with one or more of a supernatant of biologic material or a polyampholyte cryoprotectant or both. | 2021-11-25 |
| 20210361829 | BRAIDED SILK SCAFFOLD WITH ADJUSTABLE MECHANICAL AND DEGRADATION PROPERTIES, AND PREPARATION METHOD AND USE THEREOF - The present invention discloses a braided silk scaffold with adjustable mechanical and degradation properties, and a preparation method and use thereof, belonging to the field of three-dimensional scaffold materials for tendon/ligament repair. The preparation method includes braiding at least one silk strand to form a silk core; placing 1-6 bundles of silk cores in a braiding machine, and braiding at least one layer of silk cladding on the surface of the silk cores to form a silk base frame; removing sericin from the silk base frame; soaking the silk base frame in a collagen solution with a concentration of 3-20 mg/ml, and cross-linking the silk base frame in a vacuum thermal cross-linking machine to obtain the silk scaffold. The braided silk scaffold with adjustable mechanical and degradation properties according to the present invention has good mechanical properties and biocompatibility. | 2021-11-25 |
| 20210361830 | MEDICAL MATERIALS AND DEVICES - Provided herein is a composite material for use in orthopaedic applications, and an orthopaedic implant made from such material, the composite material comprising a polymeric matrix material and further comprising a filler material comprising TiO | 2021-11-25 |
| 20210361831 | HYBRID SCAFFOLD SUITABLE FOR REGENERATING ANIMAL TISSUES AND PROCESS FOR PRODUCING THE SCAFFOLD - A hybrid scaffold is disclosed which is made of materials that define peripheral layers designed to interface with the tissues in the implant site and one or more intermediate layers. The materials are combined to give the scaffold mechanical properties suitable for withstanding the stresses of the implant site. The materials are fibroin for the peripheral layers and polyurethane combined with fibroin for each intermediate layer. | 2021-11-25 |
| 20210361832 | HIP LABRUM SCAFFOLDS - Hip labrum scaffolds are generally provided. In some embodiments, the hip labrum scaffolds described herein have one or more advantageous features. For instance, some hip labrum scaffolds may have one or more properties that facilitate tissue ingrowth and/or have beneficial mechanical properties. | 2021-11-25 |
| 20210361833 | CONTROLLED HYDROGEL DELIVERY OF FOCAL ADHESION KINASE INHIBITOR FOR DECREASED SCAR FORMATION - The formation of scars at a wound site is reduced by contacting the wound site with an effective dose of an inhibitor of focal adhesion kinase (FAK) formulated in a pullulan hydrogel The release profile of the FAK inhibitor can be adjusted according to the nature of the wound, e.g., excisional wounds, burn wounds, etc. | 2021-11-25 |
| 20210361834 | NITRIC OXIDE RELEASING SURFACES FOR DECREASED FOULING, THROMBOSIS, AND INFECTION OF MEDICAL DEVICES - Embodiments of the present disclosure provide for treated articles of tubing having anti-fouling characteristics, methods of making treated articles of tubing, and the like. Disclosed herein are treated articles of tubing impregnated with a silicone oil and a nitric oxide release agent. Also described are methods for preparing a treated article of tubing and methods for delivering a pharmaceutically acceptable fluid to a subject in need thereof, wherein the fluid is transferred from a fluid source through treated articles of tubing to the subject. | 2021-11-25 |
| 20210361835 | Cell Processing System And Method With Preliminary Process Evaluation - A cell processing system includes a processor connectable to a source container filled with a biological fluid, the processor including a separator configured to separate the biological fluid from the source container into at least two streams according to a process including at least one process parameter, and a controller coupled to the processor and an input. The controller is configured to receive the at least one process parameter, to evaluate the process using the at least one process parameter before performing the process, and to carry out one or more actions based on the evaluation, such as providing an output estimate to the operator, preventing the process from being performed according to a comparison between a calculated condition and a control, or providing an error indication to the operator according to the calculated condition and a measured in-process condition. | 2021-11-25 |
| 20210361836 | MEDICAL SYSTEM AND DISPOSABLE MEDICAL VACUUM DRAINAGE BAG FOR USE WITH SAME - A disposable medical vacuum drainage bag includes a flexible enclosure made of a flexible material. The flexible enclosure is configured to define an interior chamber. The flexible enclosure has a first fluid port and a second fluid port. The flexible enclosure has a collapsed state and an expanded state. A framework is located in the interior chamber. The framework has a plurality of frame structures configured to rotate in unison about separate rotational axes between a collapsed configuration and an expanded configuration, wherein the collapsed configuration facilitates the collapsed state of the flexible enclosure and the expanded configuration facilitates the expanded state of the flexible enclosure. An actuator is coupled to the framework. The actuator is configured to rotatably transition the plurality of frame structures between the collapsed configuration and the expanded configuration. | 2021-11-25 |
| 20210361837 | METHODS AND APPARATUS TO IMPROVE BREAST MILK PRODUCTION - A breast pump having an areola stimulation assembly is provided. The breast pump may include a breast cup. The breast pump may also include a vacuum component that connects to the breast cup. Additionally, the breast pump may include an areola stimulation assembly, contained within the breast pump, that comprises an upper plate; a lower plate; and a mechanism that moves the lower plate with respect to the upper plate. | 2021-11-25 |
| 20210361838 | BREAST PUMP AND FEEDING KIT - A breast pump ( | 2021-11-25 |
| 20210361839 | PASSIVE PUMP - Apparatus is provided, including a flexible intraventricular receptacle positionable within a heart ventricle, and configured to assume a first volume upon passage of fluid that is not blood into the receptacle and a second, smaller volume upon passage of the fluid out of the receptacle. An expandable extracardiac receptacle is positionable outside of the heart, and is configured to expand upon transfer of the fluid into the extracardiac receptacle from the intraventricular receptacle and to contract upon passage the fluid out of the extracardiac receptacle. A transmyocardial conduit is disposed and allows passage of the fluid between the intraventricular receptacle and the extracardiac receptacle responsively to a cardiac cycle. During ventricular systole, a volume of fluid is expelled from the intraventricular receptacle, through the conduit, and the extracardiac receptacle, producing a corresponding decrease in a total volume of the ventricle during isovolumetric contraction of the ventricle. | 2021-11-25 |
| 20210361840 | SYSTEMS AND METHODS FOR PUMPING SALINE THROUGH A STERILIZING FILTER - A method is provided for controlling fluid flow through a tubing segment is provided in which a pump draws fluid through the tubing segment using negative pressure P. The method includes the steps of: a) operating the pump at an initial commanded fluid flow rate to draw fluid through the tubing segment; b) measuring on a continuous basis the P in the tubing segment; c) determining into which of four zones the measured P falls, a first zone being where P>X | 2021-11-25 |
| 20210361841 | BLOOD TREATMENT SYSTEMS AND METHODS - Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations. Fluid handling devices, such as pumps, valves, and mixers that to can be actuated using a control fluid may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm dividing the device into first and second compartments. | 2021-11-25 |
| 20210361842 | Media Supply Arrangement For Supplying A Medical Treatment Device - The present disclosure pertains to a media supply arrangement for supplying a medical treatment device with a medium, in particular for supplying an extracorporeal blood treatment device with a dialysis medium, wherein an air conditioning device for air conditioning of a medical treatment device coupled to the media supply arrangement is provided. | 2021-11-25 |
| 20210361843 | MEDICAL FLUID DELIVERY SYSTEM - An assembly for adding a medication or like substance to a liquid solution in a flexible bag ( | 2021-11-25 |
| 20210361844 | PERITONEAL DIALYSIS SOLUTION - In alternative embodiments, provided are solutions for peritoneal dialysis for use for maintaining or restoring the removal of small solutes and fluids in subjects with end-stage renal disease and/or congestive heart failure. In alternative embodiments, such solutions comprise carnitine, xylitol and at least one of glucose, glycerol and polydextrin. | 2021-11-25 |
| 20210361845 | HLM PUMP STOP REACTION - A heart lung machine (HLM) includes: a pump actuator; an actuator control unit (ACU) operably connected to the pump actuator; a processing unit configured to receive a set of parameter data from the actuator; a display device configured to present a subset of the set of parameter data; and an input control device operably connected to the pump actuator. The input control device includes a rotatable knob. The ACU may be configured to: determine that the pump actuator has been stopped in response to a pump-stop trigger event; determine that the rotatable knob has been rotated to a first position; and in response to determining that the rotatable knob has been rotated to the first position, starting the pump actuator. | 2021-11-25 |
| 20210361846 | Blood Processing Apparatus And Method For Detoxifying Bacterial Lipopolysaccharide - A detoxification method includes the steps of inducing flow of patient blood through an extracorporeal device inlet and outlet in fluid connection to the circulatory system of a patient. Biological agents including lipopolysaccharide (LPS) contained within patient blood can be detoxified by passing patient blood over a biochemical reactor surface having attached or immobilized | 2021-11-25 |
