47th week of 2011 patent applcation highlights part 49 |
Patent application number | Title | Published |
20110288237 | Multi-Stage Process for Producing Polyethylene with Lowered Gel Formation - The present inventions relates to a process for producing polyethylene compositions comprising polymerising polyethylene resins in a cascaded multi-stage reaction in which the reaction steps are performed in at least two slurry phase reactors (A) and (B) and at least one gas phase reactor (C) which are arranged in series in any order wherein in reactor (A) a low molecular weight ethylene homo- or copolymer fraction having a MFR | 2011-11-24 |
20110288238 | ENHANCED TRANSPORT USING MEMBRANE DISRUPTIVE AGENTS - Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontopheresis, and/or electrophoresis can also be used with the disrupting agents. | 2011-11-24 |
20110288239 | POLYMERIC POLYAMINES AND METHOD FOR PRODUCING THE SAME - The present invention discloses a polymeric polyamine which can be produced by polymerizing polyoxyalkylene-amine and a linker. The linker can be anhydride, carboxylic acid, epoxy, isocyanate or poly(styrene-co-maleic anhydride) copolymers (SMA). The present invention also discloses a method for stabilizing the Ag nanoparticles with polymeric polyamine. The polymeric polyamine serving as a stabilizer or dispersant is mixed with a water solution of silver salt and then a reducer is provided to reduce the silver ions and form an organic or a water solution of Ag nanoparticles. Water or solvent of this solution can be further removed through a heating, freezing or decompression process, and thus solid content of the solution can be increased. The concentrated solution also can be diluted to obtain a stable dispersion without aggregation. | 2011-11-24 |
20110288240 | NOVEL PHOSPHAZENE-SUPPORTED CATALYST, NOVEL COMPOUND THEREOF AND USE THEREOF - A phosphazene-supported catalyst in which a support is bonded to a group represented by the general formula (1): | 2011-11-24 |
20110288241 | DONOR-ACCEPTOR ROD-COIL DIBLOCK COPOLYMER FOR ORGANIC SOLAR CELLS AND SYNTHESIS METHOD THEREOF - The present invention features a donor-acceptor rod-coil diblock copolymer for an organic solar cell and a method for synthesizing the same. In certain embodiments, the present invention features a donor-acceptor rod-coil diblock copolymer for an organic solar cell based on polythiophene and fullerene and a method for synthesizing the same. Preferably, the block copolymer exhibits a nanofibrillar structure in solid film and, when added to an active layer of a bulk heterojunction organic solar cell consisting of poly(3-hexylthiophene) (P3HT) and [6,6]-phenyl-C | 2011-11-24 |
20110288242 | ADHESIVE POLYURETHANE POWDER CAPABLE OF BEING ACTIVATED BY HEAT - A heat-activable powder adhesive composition for use in bonding a component to a surface such as glass is disclosed. The composition of the disclosed invention includes at least two polymers, at least one solid di- or poly-isocyanate in powder form, and a catalyst. The two polymers each have a melting point above 40° C. and are selected from the group consisting of di-functional polymers and multi-functional polymers. The preferred method of preparing the composition of the disclosed invention includes first forming three parts, including a first melted part comprising the polymers, a second melted part comprising the polymers and a catalyst, and a third part comprising the isocyanate. Once cooled, each of the first and second parts forms solid blocks which are fragmented and sieved. The three dry parts are then brought together to form the adhesive powder of the disclosed invention. The adhesive powder can be pre-applied to the attachment surface of a component to be bonded. The composition does not require either a deactivating agent or a blocking agent for deactivating the isocyanate or the catalyst nor does it require either a deactivated isocyanate or a deactivated catalyst. | 2011-11-24 |
20110288243 | Carbonate Block Copolymers - Disclosed are novel carbonate block copolymers and methods of making the same. Some carbonate block copolymers include oligomeric carbonate blocks bonded to one or more silicon-containing non-carbonate block, wherein the silicon-containing non-carbonate block is comprised of a diamine moiety and the carbonate block is joined to the silicon-containing non-carbonate block through a urethane group. Other carbonate block copolymers include oligomeric carbonate blocks bonded to one or more non-silicon-containing non-carbonate block, wherein the non-silicon-containing non-carbonate block is comprised of a diamine moiety and the carbonate block is joined to the non-silicon-containing non-carbonate block through a urethane group. The carbonate block may include Bisphenol-A moieties. The diamine from which either the silicon-containing or non-silicon-containing non-carbonate block is derived may be primary, secondary or tertiary. | 2011-11-24 |
20110288244 | PHOSPHORUS-FUNCTIONALIZED POLY(ARYL ETHER KETONE)S AND THEIR PREPARATION PROCESS AND USE - A phosphorus functionalized poly(aryl ether ketone) developed by using 9,10-dihydro-9-oxa-10-phosphaphenanthrene 10-oxide (DOPO) to modify a poly(aryl ether ketone) is provided. The phosphorus functionalized poly(aryl ether ketone) can include reactive functional groups, such as hydroxy, amino, and carboxyl groups for further modification. | 2011-11-24 |
20110288245 | ALKOXY-CROSSLINKING RUBBER MIXTURES COMPRISING NIOBIUM OR TANTALUM CONDENSATION CATALYSTS - The invention provides alkoxy-crosslinking rubber mixtures (M) which comprise a compound of the general formula (1) M(OR | 2011-11-24 |
20110288246 | Curable Silicone Composition That Provides A Highly Transparent Cured Silicone Material - A curable silicone composition comprises (A) (A-1) an alkenyl-containing dialkylpolysiloxane and a viscosity of at least 1,000 mPa·s to not more than 20,000 mPa·s and (A-2) an alkenyl-containing, resin-form organopolysiloxane that comprises the SiO | 2011-11-24 |
20110288247 | Continuous Take Off Technique and Pressure Control of Polymerization Reactors - Techniques and systems for producing a polyolefin using reactors in series are described. Described embodiments include techniques and systems for polymerizing a monomer in a first polymerization reactor to form a first polyolefin, discharging a first slurry continuously from the first polymerization reactor to a second polymerization reactor, and discharging a second slurry continuously from the second polymerization reactor. Using continuous take-off devices disposed on either or both reactors, pressure control may be attained such that the rate of transfer between and withdrawal from both reactors are within a desired range. | 2011-11-24 |
20110288248 | Reduced reactor fouling - Fouling in a dispersed phase reactor in the presence of a phosphinimine catalyst and MAO may be reduced by reducing the loading of the phosphinimine catalyst to provide from 0.02 to 0.031 mmol of transition M per g of catalyst while still maintaining a productivity of not less than 2500 g of polymer/gram of catalyst. The catalyst may optionally be used in the presence of an antistatic agent. | 2011-11-24 |
20110288249 | Halogen Substituted Heteroatom-Containing Metallocene Compounds for Olefin Polymerization - Halogen substituted metallocene compounds are described and comprise one or more monocyclic or polycyclic ligands that are pi-bonded to the metal atom and include at least one halogen substituent directly bonded to an sp | 2011-11-24 |
20110288250 | Copolymer and Production Process Thereof - A homopolymer having a monomer unit such as an isopropylidene diallylmalonate unit; a process for producing said homopolymer comprising the step of homopolymerising a monomer such as isopropylidene diallylmalonate; a copolymer containing said monomer unit and an ethylene unit and/or α-olefin unit; and a process for producing said copolymer comprising the step of copolymerizing a monomer such as isopropylidene diallylmalonate with at least ethylene and/or an α-olefin. | 2011-11-24 |
20110288251 | POLYMERISATION INITIATOR - The invention relates to novel O-dialkylamino-isoureas and polymerizable compositions comprising these O-dialkylamino-isoureas of compounds of the general formula (I). The invention further relates to the use of O-dialkylamino-isoureas as polymerization initiators, especially to prepare coatings or for controlled degradation of polyolefins. | 2011-11-24 |
20110288252 | DIALKOXY- OR DIHYDROXYPHENYL RADICALS CONTAINING SILANES, ADHESIVES PRODUCED THEREFROM AND METHOD FOR PRODUCING SILANES AND ADHESIVES - The present invention relates to silanes with the formula (I) R | 2011-11-24 |
20110288253 | MULTI-COLORED CONJUGATED POLYMERS WITH HIGHLY TRANSMISSIVE OXIDIZED STATE - Embodiments of the invention are directed to random conjugated copolymers comprising a plurality of one or more different donor (D) repeating units and a plurality of at least one acceptor (A) repeating unit. At least one of the D units has a solubilizing substituent, statistically a portion of the A repeating units are separated from each other by only one D units and a plurality of the A unit are adjacent to one the D units having the solubilizing substituents. The random conjugated copolymers are black or colored in the neutral state and highly transmissive in the oxidized state. The random conjugated copolymers have the structure -[(D) | 2011-11-24 |
20110288254 | AROMATIC ETHER AND ALKYNYL CONTAINING PHTHALONITRILES - Compounds having the formulas below. R is an aromatic-containing group. Each M is an alkali metal. Each m is a positive integer. The value of n is a positive integer. The value p is 0 or 1. If p is 0 then n is 1. A thermoset made by curing a composition containing the below phthalonitrile monomers. | 2011-11-24 |
20110288255 | METHOD FOR PRODUCING AMIDE COMPOUND - A method for producing an amide compound from a nitrile compound in an aqueous medium in the presence of a catalyst having a nitrile hydratase activity wherein the concentration of benzene in the aqueous medium is 4.0 ppm or less and a method for producing an amide-based polymer excellent in quality from the amide compound. Also provided are a method for more efficiently producing an acrylamide with higher quality by a microbial catalyst containing a nitrile hydratase and the like and a method for producing an acrylamide-based polymer, which is excellent in hue, has a good balance between water solubility and high molecular weight and is excellent in quality. | 2011-11-24 |
20110288256 | PROCESS TO MAKE ALPHA OLEFINS FROM ETHANOL - The present invention relates to a process to make alpha olefins comprising:
| 2011-11-24 |
20110288257 | SEALING MATERIAL FOR OPTICAL ELEMENT AND SEALED OPTICAL ELEMENT - A sealing material for optical elements with excellent transparency, crack resistance, and heat resistance which can produce a cured product of the sealing material and a sealed optical element are provided. The sealing material for optical elements comprising a compound with a ladder structure, which contains a repeating unit of the following formula (A) in the molecule as a major component, the compound being obtained by condensing a compound (1) shown by the formula, R | 2011-11-24 |
20110288258 | CROSSLINKED POLYAMIDE - A process for crosslinking polyamide comprises a diisocyanate or a diacyl halide being reacted with a lactam A at a temperature of from (−30) to 150° C. and next reacting with a lactam B, a catalyst and an activator at a temperature of from 40 to 240° C. | 2011-11-24 |
20110288259 | PROCESS FOR PRODUCTION OF THERMOPLASTIC CURED EPOXY RESIN WITH TRANSPARENCY TO VISIBLE LIGHT, AND THERMOPLASTIC EPOXY RESIN COMPOSITION - A process for the production of a thermoplastic cured epoxy resin which is transparent to visible light, characterized by curing (A) an epoxy compound having two epoxy groups in one molecule with (B) a compound having two phenolic hydroxyl groups in one molecule by means of (C) a cure accelerator consisting of at least one compound represented by general formula (1): | 2011-11-24 |
20110288260 | MAIN-CHAIN BENZOXAZINE OLIGOMER COMPOSITIONS, AND METHOD FOR THE PREPARATION THEREOF - Disclosed are benzoxazine compositions where oxazine rings are part of the polymer main-chain. The benzoxazine oligomers are prepared by the reaction of a bisphenol and an aldehyde, such as formaldehyde or paraformaldehyde, with one or more diamines or polyamines, and optionally with one or more monofunctional amines or monofunctional phenols. Also disclosed are benzoxazine monomers prepared from a bisphenol, an aldehyde, such as formaldehyde or paraformaldehyde, and a monofunctional amine, which benzoxazine monomers may be optionally used as reactive diluents. Further disclosed are benzoxazine monomers are prepared from a diamine, and aldehyde, such as formaldehyde or paraformaldehyde, and a monofunctional phenol, which benzoxazine monomers may also be optionally used as reactive diluents. | 2011-11-24 |
20110288261 | OPTICAL FILM - The object of this invention is to provide an optical film formed of a copolycarbonate having a desired chromatic dispersion and low photoelasticity and having excellent melt processability. | 2011-11-24 |
20110288262 | HIGH MOLECULAR WEIGHT POLY(2,6-DIMETHYL-1,4-PHENYLENE ETHER) AND PROCESS THEREFOR - A poly(2,6-dimethyl-1,4-phenylene ether) having a high molecular weight and a reduced content of low molecular weight species can be prepared by a method that includes specific conditions for the oxidative polymerization, chelation, and isolation steps. The poly(2,6-dimethyl-1,4-phenylene ether) is particularly useful for the fabrication of fluid separation membranes. | 2011-11-24 |
20110288263 | BIOBASED POLYESTERS - The present invention relates to polyesters prepared from benzene, cyclohexene and cyclohexane compounds having carboxylic acid groups at the 1 and 4, and optionally the 2, positions, such as terephthalic acid or dimethyl terephthalates, and alkylene glycols, such ethylene glycol or 1,4-butane diol. The invention also relates to processes for preparing such polyesters. The invention also relates to such polyesters derived from starting materials derived from renewable resources. | 2011-11-24 |
20110288264 | POLYETHER ESTER BLOCK COPOLYMER - To provide a polyether ester block copolymer which has surface hardness suitable to be applied to a structural member and excellent in sound deadening quality and tribological property, a polyether ester block copolymer of the present invention comprises (a) aromatic dicarboxylic acid unit, (b) 1,3-propanediol and/or 1,4-butanediol unit and (c) long chain diol unit mainly including polyoxytrimethylene glycol, wherein the durometer hardness (type D), measured according to the principle of the method described in JIS K6253, is 40 or larger and 78 or smaller. | 2011-11-24 |
20110288265 | PLASTIC CONTAINERS AND CONDUITS - The invention relates to a plastic container or conduit for a cooling system, a heating system, an air intake system, an exhaust system, a pressure system or a fuel system, consisting of or comprising a part or a layer made of a thermoplastic polymer composition comprising a semi-crystalline semi-aromatic polyamide having a glass transition temperature (Tg) of at least 115° C. | 2011-11-24 |
20110288266 | HEAT-SHRINKABLE FILM - A heat-shrinkable film including at least one gas-barrier layer (A). The gas-barrier layer (A) is made of a stretched film of a polyamide resin which is obtained from a diamine component comprising 70 mol % or more of m-xylylenediamine and a dicarboxylic acid component comprising 80 to 98 mol % of α,ω-linear aliphatic dicarboxylic acid having 4 to 20 carbon atoms and 2 to 20 mol % of isophthalic acid. The polyamide resin has a moderate crystallization speed and does not cause whitening even when stretched at low temperature, to provide a heat-shrinkable film combining high heat shrinkability and high transparency. | 2011-11-24 |
20110288267 | Method and Device for Cleaning an Absorptive Polyester - In a method for cleaning an absorptive polyester, the polymer is dissolved in a first solvent ( | 2011-11-24 |
20110288268 | POLYLACTIC ACID RESIN, TEXTILE PRODUCTS OBTAINED THEREFROM, AND PROCESSES FOR PRODUCING TEXTILE PRODUCTS - A flat yarn includes a linear polylactic acid resin prepared from lactic acid monomers, wherein at least 95 mol % of the lactic acid is an L-isomer. | 2011-11-24 |
20110288269 | Design of Spacers To Increase The Expression of Recombinant Fusion Proteins - The present invention relates to fusion proteins. The invention specifically relates to compositions and methods of Tf-based fusion proteins that demonstrate a high-level expression of transferrin (Tf)-based fusion proteins by inserting a helical linker between two protein domains. | 2011-11-24 |
20110288270 | COMPARATIVE LIGAND MAPPING FROM MHC CLASS I POSITIVE CELLS - The present invention relates generally to a methodology for the isolation, purification and identification of peptide ligands presented by MHC positive cells. In particular, the methodology of the present invention relates to the isolation, purification and identification of these peptide ligands from soluble class I and class II MHC molecules which may be from uninfected, infected, or tumorigenic cells. The methodology of the present invention broadly allows for these peptide ligands and their cognate source proteins thereof to be identified and used as markers for infected versus uninfected cells and/or tumorigenic versus nontumorigenic cells, with said identification being useful for marking or targeting a cell for therapeutic treatment or priming the immune response against infected/tumorigenic cells. | 2011-11-24 |
20110288271 | AGENT DERIVED FROM TORTOISE SPLEEN STIMULATING MAMMALIAN HEMOPOIESIS - The present invention relates to a proteinaceous extract derived from tortoise spleen and to a tetrapeptide FTGN, which have stimulatory activity on hematopoietic cells. In particular, this tetrapeptide enhances hemopoietic reconstruction, and bone marrow re-population, reduced as a consequence of a high dose of radiation or chemotherapy exposure. The invention further provides pharmaceutical compositions comprising as an effective ingredient the proteinaceous extract or the FTGN tetrapeptide and ex vivo and in vivo methods of treatment employing them. | 2011-11-24 |
20110288272 | MODIFIED CRY3A TOXINS AND NUCLEIC ACID SEQUENCES CODING THEREFOR - Methods for making a modified Cry3A toxin are disclosed. Such methods include the insertion of a protease recognition site that is recognized by a gut protease of a target insect, such as corn rootworm, into at least one position of a Cry3A toxin so that a modified Cry3A toxin is thus designed. The coding sequence of the modified Cry3A toxin may be transformed into a host cell and the host cell grown under conditions that allow the host cell to produce the modified Cry3A toxin. The host cell may be a plant cell and the plant may be comprised in a transgenic plant. Thus, the transgenic plant may be used to produce the modified Cry3A toxin. | 2011-11-24 |
20110288273 | HIGH YIELD DIALYSIS-FREE PROCESS FOR PRODUCING ORGANOSOLUBLE REGENERATED SILK FIBROIN - The invention relates to a simple and high yield process for producing a regenerated silk fibroin which does not need dialysis. Particularly, a process of the invention is characterized in that the silk fibroin is precipitated by applying a shear stress and/or changing the solvent power of the fibroin solution. The process of the invention simplifies the process of producing silk fibroin and greatly shortens the process time to 1 to 2 hours, whereas the conventional dialysis process is complex and needs around 2 to 3 days. In addition to reducing the time needed, the process of the invention can increase productivity of silk fibroin by at least 8%. | 2011-11-24 |
20110288274 | Designer collagens and use thereof - The present invention identified a recombinant synthetic collagen containing a triple helical backbone protein produced in a prokaryotic expression system where the protein contains at least one ‘inserted’ biologically active sequence(s). | 2011-11-24 |
20110288275 | Modified Proteins, Designer Toxins, and Methods of Making Thereof - The present invention concerns methods of reducing the antigenicity of a proteinaceous compound while maintaining the compounds biological activity, as well as proteinaceous compositions with biological activity but reduced antigenicity. These methods and compositions have significant benefits to a subject in need of such compounds and compositions. Also included are modified toxin compounds that are truncated and/or possess reduce antigenicity. Such designer toxins have therapeutic, diagnostic, and preventative benefits, particularly as immunotoxins. Methods of treating cancer using these immunotoxins are provided. | 2011-11-24 |
20110288276 | CRYSTALS AND STRUCTURE OF A HUMAN IgG Fc VARIANT WITH ENHANCED FcRn BINDING - Provided herein are crystalline forms of a human IgG Fc variant comprising triple-mutation M252Y/S254T/T256E that provides for increased binding affinity to human neonatal Fc receptor, methods of obtaining such crystals and high-resolution X-ray diffraction structures and atomic structure coordinates. Also provided are machine readable media embedded with the three-dimensional atomic structure coordinates of the human IgG Fc variant and methods of using them. | 2011-11-24 |
20110288277 | Media For Membrane Ion Exchange Chromatography Based On Polymeric Primary Amines, Sorption Device Containing That Media, And Chromatography Scheme And Purification Method Using The Same - Media and devices, such as anion exchangers including such media, wherein the media is a membrane having a surface coated with a polymer such as a polyallylamine. The resulting membrane offers stronger binding of protein impurities and superior removal of host cell proteins from biological samples than conventional ligands based on quaternary ammonium salts, including trimethylammonium ligands. Also described is a chromatography scheme and method for purifying monoclonal antibodies, wherein the anion exchange sorber is placed downstream of an affinity column (such as Protein A or Protein G affinity column) and optionally one or more polishing devices such as cationic exchange columns. Little or no dilution of the cation exchanger pool (or affinity column exchange pool where no cation exchanger is used) is necessary to lower the conductivity of the sample. The sorber functions well to strongly bind host cell proteins and other impurities in biological samples even at high conductivities and pH. | 2011-11-24 |
20110288278 | DIAGNOSTIC AGENT AND THERAPEUTIC AGENT FOR PANCREATIC CANCER - The present invention provides a novel diagnostic or therapeutic method for pancreatic cancer employing a blood marker. The present invention provides a diagnostic or therapeutic drug for pancreatic cancer containing an anti-AMIGO2 antibody. | 2011-11-24 |
20110288279 | COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES - Disclosed Herein are Non-Natural Amino Acids and Polypeptides that Include at Least One non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses. | 2011-11-24 |
20110288280 | COELENTERAMIDE ANALOGS - There has been a need for coelenteramide analogs or the like that produce fluorescent proteins which exhibit different fluorescent characteristics from those of the existing fluorescent proteins. Disclosed is a compound represented by general formula (1) (wherein R | 2011-11-24 |
20110288281 | METHOD FOR 2-SULFATION OF GLYCOSIDES - Method for selective 2-sulfation of glycosides. | 2011-11-24 |
20110288282 | METHOD OF PREPARING DEOXYRIBOFURANOSE COMPOUNDS - The invention relates to methods for making deoxyribofuranose compounds such as compound (2) which are useful intermediates in the preparation of pharmaceutical compounds such as 5-amino-3-(2′-O-acetyl-3′-deoxy-β-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidin-2-one and the like. | 2011-11-24 |
20110288283 | PROCESS FOR PRODUCING GLYCOSAMINOGLYCANS - The invention provides a process for the production of a composition comprising a glycosaminoglycan, said process comprising subjecting a homogenate of glycosaminoglycan-containing animal material to chromatography using a chromatographic matrix in the form of a membrane adsorber. | 2011-11-24 |
20110288284 | METHODS AND COMPOSITIONS FOR ISOLATING POLYNUCLEOTIDES - Methods of isolating target double-stranded polynucleotides with internal single-stranded regions are provided. Compositions and kits comprising double-stranded polynucleotides with internal single-stranded regions are also provided | 2011-11-24 |
20110288285 | Novel reagent compounds and methods of making same - The present invention describes novel compounds and methods for capping reactive groups on support and during multistep synthesis. These new capping reagents are also useful for high quality synthesis on solid supports and surfaces used as microarrays, biosensors, or in general as biochips. The compounds are also useful for controlling surface density of reactive groups on a support. The compounds may also be used to modify the hydrophilic/hydrophobic characteristics of a surface or a molecule. The compounds have functional utility in various applications in the fields of genomics, proteomics, diagnostics and medicine. | 2011-11-24 |
20110288286 | PROCESS FOR THE ENZYMATIC PRODUCTION OF CYCLIC DIGUANOSINE MONOPHOSPHATE EMPLOYING A DIGUANYLATE CYCLASE COMPRISING A MUTATED RXXD MOTIF - A process is disclosed for the production of cyclic di-guanosine monophosphate (c-di-GMP) without the use of protecting groups by means of an enzymatic synthesis. The process comprises the coupling of two guanosine triphosphate (GTP) molecules so as to form a c-di-GMP molecule. This is done under the influence of a mutant diguanylate cyclase (DGC) comprising the amino acid sequence V153M154G155G156. It has been found that the DGC is obtainable from inclusion bodies, and therewith can be made available in amounts sufficient to improve the c-di-GMP synthesis. Particularly, the latter synthesis can be conducted in a one-pot method starting from commercially available bulk chemicals and allows upscaling to a commercial production scale. | 2011-11-24 |
20110288287 | Halogen Substituted Saccharide, Method for Producing Same, Reaction Composition of Same and Device for Producing Same - The present invention provides: a method for synthesizing a halogen-substituted saccharide from a leaving group-substituted saccharide in a short-time and continuously; a reaction composition; and a device for synthesis of same, i.e., the method being for synthesizing a halogen-substituted saccharide from a leaving group-substituted saccharide by a halogen-substituted saccharide synthesis reaction using a subcritical fluid or a supercritical fluid as the reaction solvent; the reaction composition of the same being an aqueous solution of halogen-substituted saccharide; and the device for synthesis being a device for producing the same, the method being for producing a halogen-substituted saccharide with a subcritical fluid or a supercritical fluid at a temperature of 100 to 400° C. and a pressure of 0.1 to 40 MPa or a mixed solvent of aprotic organic solvent or inorganic solvent mixed therein as the reaction solvent, under catalyst-free condition, by introducing the leaving group-substituted saccharide and the reaction solvent into a circulating-type high-temperature and high-pressure device to produce selectively a halogen-substituted saccharide while reducing the amount of energy consumption and the amount of waste, at high yield, high selectivity, high speed and continuously. | 2011-11-24 |
20110288288 | Process for the preparation of 17-0-vinyl- triflates as intermediates - A compound of formula (I) or a pharmaceutically-acceptable salt thereof, may be made by a process including a triflating step by which a ketone of formula (II) is converted into a triflate of formula (III) in the presence of a base comprising a tertiary or heterocyclic amine such that the pK | 2011-11-24 |
20110288289 | Preparation of Carbapenem Intermediate and Their Use - The present invention relates to preparing carbapenem intermediates that are useful to produce Ertapenem, Meropenem and Doripenem. | 2011-11-24 |
20110288290 | PROCESS FOR THE PREPARATION OF CARBAPENEM USING CABAPENEM INTERMEDIATES AND RECOVERY OF CABAPENEM - The present invention relates to preparing carbapenem intermediates that are useful to produce Ertapenem, Meropenem and Doripenem; and provides an effective process for recovering ertapenem compounds. | 2011-11-24 |
20110288291 | PYRAZINOOXAZEPINE DERIVATIVES - Provided is a compound having a serotonin 5-HT | 2011-11-24 |
20110288292 | MATERIALS FOR ORGANIC ELECTROLUMINESCENCE DEVICES - The present invention relates to substituted benzo[c]phenanthrene derivatives and to the production and to the use thereof in electronic devices, and to the electronic devices themselves. The present invention relates in particular to benzo[c]phenanthrene derivatives substituted with at least one aromatic unit or at least one diarylamino unit. | 2011-11-24 |
20110288293 | ISOQUINOLINE DERIVATIVE - A compound represented by formula (I) or a pharmaceutically acceptable salt thereof has an effect of inhibiting CRTH2 and, therefore, is useful as a preventive or a remedy for allergic diseases such as asthma, atopic dermatitis and allergic rhinitis. | 2011-11-24 |
20110288294 | Preparation process for an inhibitor of a blood clotting factor - The invention relates to a process for the preparation of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide (I) from 5-chlorothiophene-2-carboxylic acid and 4-[4-((S)-5-aminomethyl-2-oxooxazolidin-3-yl)phenyl]morpholin-3-one (II) | 2011-11-24 |
20110288295 | 1,3,5-TRIAZINE DERIVATIVE, PROCESS FOR PRODUCING SAME, AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME - A 1,3,5-triazine derivative represented by formula (1): | 2011-11-24 |
20110288296 | PRODUCTION AND USE OF ZINC AMIDES - The application relates to a reagent of the general formula | 2011-11-24 |
20110288297 | Pyrrolo[2,3-d]Pyrimidine Derivatives; Their Intermediates and Synthesis - This invention relates to methods and intermediates useful for the synthesis of pyrrolo[2,3-d]pyrimidine compounds. Specifically novel synthetic methods and intermediates for the synthesis of 3-{(3R,4R)-4-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino}-piperidin- | 2011-11-24 |
20110288298 | NOVEL POLYMORPH OF EMTRICITABINE AND A PROCESS FOR PREPARING OF THE SAME - A polymorph of emtricitabine, wherein said polymorph displays angular positions of characteristic peaks in powder X-ray diffraction pattern 13.61±0.2, 15.54±0.2, 19.49±0.2, 20.55±0.2, 25.89±0.2, 28.09±0.2 and 29.10±0.2. A pharmaceutical composition comprising a polymorph of emtricitabine displaying angular positions of characteristic peaks in powder X-ray diffraction pattern 13.61±0.2, 15.54±0.2, 19.49±0.2, 20.55±0.2, 25.89±0.2, 28.09±0.2 and 29.10±0.2. A process for the preparation of a polymorph of emtricitabine comprising the steps of (a) dissolving crude emtricitabine in polar organic solvent by heating at a temperature of at least 40° C. and not more than 150° C. to form a reaction mixture optionally decreasing the concentration of polar organic solvent in said reaction mixture; cooling the reaction mixture obtained in step (a); and separating the solid from the cooled reaction mixture resulted in step (b). | 2011-11-24 |
20110288299 | TRICYCLIC AMINE COMPOUND - A compound represented by the following general formula (I): | 2011-11-24 |
20110288300 | Organic and inorganic photosensitizer dyes - The present invention discloses organic and inorganic photosensitizer dyes as the following formulas (1) to (3), wherein the substituents “A, B, D and G” are as defined in claim | 2011-11-24 |
20110288301 | AZA-INDOLES AND RELATED COMPOUNDS HAVING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ANTAGONIST BIOLOGICAL ACTIVITY - The present invention provides compounds are disclosed herein having the formula: | 2011-11-24 |
20110288302 | Catalyst Coated Honeycomb Substrates and Methods of Using Them - An essentially nonporous honeycomb substrate having greater than 900 cells per square inch and with a catalyst coating having a thickness less than 1 micron. The coated essentially nonporous honeycomb may be used, for example, for gas phase reactions. | 2011-11-24 |
20110288303 | Method of Fabricating I-123-IBOX - A method is provided for fabricating I-123-IBOX. I-123-IBOX is used for SPECT of brain. During the fabrication, radioactivity of reaction vial and purification column can be detected. Thus, I-123-IBOX can be obtained in a short time through a simple process with reduced radioactive harms. | 2011-11-24 |
20110288304 | Process for Preparing 1-Alkyl-3-difluoromethyl-5-hydroxypyrazoles - The present invention relates to a process for preparing 1-alkyl-3-difluoromethyl-5-hydroxypyrazoles, which are valuable intermediates for the production of fungicides. | 2011-11-24 |
20110288305 | Process for the preparation of 5-Fluoro-1-alkyl-3-fluoroalkyl-1H-pyrazole-4-carbonyl Chlorides and Fluorides - The present invention relates to a novel process for the preparation of 5-fluoro-1-alkyl-3-fluoroalkyl-1H-pyrazole-4-carbonyl halides and the intermediates occurring in this process, ethyl 5-chloro-1-methyl-3-difluoromethyl-1H-pyrazole-4-carboxylate and ethyl 5-fluoro-1-methyl-3-difluoromethyl-1H-pyrazole-4-carboxylate. | 2011-11-24 |
20110288306 | METHODS OF MAKING FUSED THIOPHENES - β″-di-R-substituted fused thiophene (DCXFT4) compounds, and a method for making a compound of the formula (V): | 2011-11-24 |
20110288307 | METHOD FOR MANUFACTURING SULFOLENE COMPOUND AND METHOD FOR MANUFACTURING SULFOLANE COMPOUND - An object of the present invention is to provide a method for manufacturing a sulfolene compound, the method being capable of inhibiting generation of polymers. Another object of the present invention is to provide a method for manufacturing a sulfolane compound, the method being capable of controlling inhibition of hydrogenation catalyst activity and smoothly hydrogenating a sulfolene compound. | 2011-11-24 |
20110288308 | PROCESS FOR DIMERIZATION OF ETHYLENE TO BUT-1-ENE USING A COMPOSITION COMPRISING A TITANIUM-BASED COMPLEX AND AN ALKOXY LIGAND FUNCTIONALIZED BY A HETEROATOM - The invention describes a process for the selective dimerization of ethylene to but-1-ene using a catalytic composition comprising at least one organometallic titanium complex, said organometallic complex containing at least one alkoxy type ligand functionalized by a heteroatom selected from nitrogen, oxygen, phosphorus, sulphur, arsenic and antimony or by an aromatic group. | 2011-11-24 |
20110288309 | Sequestration of Carbon Dioxide Using Metal Oxides - Embodiments of the present invention relate to carbon dioxide sequestration systems and methods. In an embodiment, the invention includes a method of sequestering carbon dioxide. The method can include mixing carbon dioxide with an alcohol to form a reaction mixture and contacting the reaction mixture with a metal oxide catalyst under reaction conditions sufficient to produce a carbonate as a reaction product. In an embodiment, the invention includes a carbon dioxide sequestration system. The system can include a carbon dioxide supply source, an alcohol supply source, and a reaction vessel. A metal oxide catalyst can be disposed within the reaction vessel. The system can be configured to mix carbon dioxide from the carbon dioxide supply source with an alcohol from the alcohol supply source to form a reaction mixture and contact the reaction mixture with the metal oxide catalyst. Other embodiments are also described herein. | 2011-11-24 |
20110288310 | CYCLOHEXANE 1,4 CARBOXYLATES - The present invention relates to cyclohexanes having carboxylate derivatives at the 1 and 4, and optionally the 2, position. The invention also relates to processes for preparing such compounds wherein a portion of the starting materials utililzed is derived from renewable resources. | 2011-11-24 |
20110288311 | NOVEL TEREPHTHALIC AND TRIMELLITIC BASED ACIDS AND CARBOXYLATE DERIVATIVES THEREOF - The present invention relates to novel substituted and unsubstituted terephthalic acid and carboxylate derivatives and products prepared therefrom having a significant renewable content. The invention also relates to processes for preparing substituted and unsubstituted terephthalic and carboxylate derivatives thereof wherein a portion of the starting materials utilized is derived from renewable resources. The invention also relates to novel cyclohexene based intermediates prepared in these processes and to conversion of these intermediates to substituted and unsubstituted cyclohexane-1,4-dicarboxylates and carboxylate derivatives thereof and novel forms of the resulting products having renewable content. The invention also relates to products prepared from substituted and unsubstituted terephthalic acid and carboxylate derivatives thereof derived from starting materials derived from renewable resources. | 2011-11-24 |
20110288312 | METHOD FOR STORING AND TRANSPORTING CYCLIC DIESTERS - The present invention relates to a method for storing and/or transporting intramolecular cyclic esters (lactones), in particular lactide. | 2011-11-24 |
20110288313 | PROCESS FOR MODIFYING DRUG CRYSTAL FORMATION - A process for modifying the crystal habit of acicular drug substances, crystals obtained by such a process, and particular crystal forms or modifications of mycophenolic acid or mycophenolate sodium are provided, as well as pharmaceutical compositions comprising the crystals, methods of treatment and uses thereof. | 2011-11-24 |
20110288314 | PHLOROGLUCINOL DERIVATIVES FROM ECKLONIA CAVA HAVING ANTI-HIV-1 INHIBITORY ACTIVITY - The present invention relates to a pharmaceutical composition and health functional food having anti-HIV-1 inhibitory activity containing phloroglucinol derivative, 6,6′-bieckol as an effective ingredient, EC extract and its phloroglucinol derivative, 6,6′-bieckol according to the present invention does not show cytotoxic effect compared to other tannin, and have effects to inhibit the HIV-1 induced syncytia formation and the p24 antigen production as well as the HIV-1 reverse transcriptase activity. | 2011-11-24 |
20110288315 | PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE COMPOUND - A 2-aryl-2-halomethyl-4-chloromethyl-1,3-dioxolane (A) can be produced conveniently without decreasing its optical purity by reacting an optically active monochlorohydrin and an aryl (halomethyl) ketone (starting materials) with each other in the presence of an acid catalyst. From the optically active compound (A) thus produced, an optically active carboxylic acid (2-aryl-2-halomethyl-1,3-dioxolan-4-yl)methyl ester and an optically active sulfonic acid (2-aryl-2-halomethyl-1,3-dioxolan-4-yl)methyl ester (both of which are useful intermediates for the production of ketoconazole) can be produced with good efficiency. An optically active trans-carboxylic acid (2-aryl-2-halomethyl-1,3-dioxolan-4-yl)methyl ester can be isomerized into its cis-form in the presence of an acid catalyst. | 2011-11-24 |
20110288316 | METHOD FOR PRODUCING PROPYLENE OXIDE - A method for producing propylene oxide which comprises reacting propylene, oxygen and hydrogen, in the presence of a titanosilicate and a noble metal supported on silylated active carbon, in a solvent. | 2011-11-24 |
20110288317 | 14-HYDROXY-DOCOSAHEXAENOIC ACID COMPOUNDS - The invention describes novel 14-hydroxy docosahexaenoic acid (DHA) analogues, their preparation, isolation, identification, purification and uses thereof. | 2011-11-24 |
20110288318 | METHOD FOR REMOVING SOLUTE FROM A SOLID SOLUTE-BEARING PRODUCT - The process and apparatus are for removing a solute from a solute-bearing solid product by means of a solvent which remains in liquid state throughout the entire oil extraction process. In one embodiment, the solvent is normally in gaseous state at ambient temperature and pressure values, but is used mainly in liquid state within the method and apparatus of the present invention by maintaining such pressure and temperature values within the apparatus so that the solvent will remain in this liquid state. | 2011-11-24 |
20110288319 | FILTER FOR DEEP FRYER - Disclosed is a filter suitable for use with a deep fryer for filtering foreign particulates, such as solid particles, from cooking oil or shortening to minimize the carbonation of such particles and extend the useful life of the cooking oil. In particular, the filter does not use disposable paper filtration media. | 2011-11-24 |
20110288320 | PURIFICATION TREATMENT OF FATTY MATERIALS - A process for the removal of impurities from fatty materials comprising the steps of providing a fatty material that may already have undergone some purification treatment, adding an aqueous suspension of liquid adsorbent to the fatty material and causing it to form a mixture with the fatty material, optionally adding some water to the mixture, and forming an aqueous phase separate from the fatty material and removing the aqueous phase from the fatty material. | 2011-11-24 |
20110288321 | Nano-Linked Metallocene Catalyst Compositions and Their Polymer Products - The present invention provides polymerization catalyst compositions employing novel dinuclear metallocene compounds. Methods for making these new dinuclear metallocene compounds and for using such compounds in catalyst compositions for the polymerization and copolymerization of olefins are also provided. | 2011-11-24 |
20110288322 | DERIVATIVES OF TRIS(2-HYDROXYPHENYL)METHANE, THEIR PREPARATION AND USE - New types of derivatives of tris(2-hydroxyphenyl)methanes which have, as functional groups, polyalkoxy groups or polyalkoxy groups modified with terminal hydrophilic groups, preparation of such compounds and their use, especially as surfactants and thickeners. | 2011-11-24 |
20110288323 | METHOD FOR PREPARING ACROLEIN FROM GLYCEROL OR GLYCERINE - The invention relates to a method for preparing acrolein from glycerol or glycerine, comprising dehydrating glycerol or glycerine in the presence of a catalyst consisting of at least a) a mixed oxide of zirconium and at least one metal, said metal being selected from niobium, tantalum and vanadium, b) a zirconium oxide and at least one metal oxide, the metal being selected from niobium, tantalum and vanadium, c) a silicon oxide and a mixed oxide of zirconium and at least one metal, the metal being selected from tungsten, cerium, manganese, niobium, tantalum, titanium, vanadium and silicon, d) a silicon oxide and a mixed oxide of zirconium and at least one metal, the metal being selected from tungsten, cerium, manganese, niobium, tantalum, vanadium and titanium, e) a titanium oxide and a mixed oxide of zirconium and at least one metal, said metal being selected from tungsten, cerium, manganese, niobium, tantalum, titanium, vanadium and silicon, f) a titanium oxide and a mixed oxide or zirconium and at least one metal, said metal being selected from tungsten, cerium, manganese, niobium, tantalum, titanium, vanadium and silicon. The method can be used for producing -3-(methylthio)propionic (MMP) aldehyde, 2-hydroxy-4-methylthiobutyronitrile (HMTBN), methionine and analogues thereof from acrolein. | 2011-11-24 |
20110288324 | METHOD FOR MANUFACTURING COMPOUNDS INCLUDING NITRILE FUNCTIONS - A process for the preparation of compounds containing nitrile functions and, more specifically, compounds containing two nitrile functions, such as succinonitrile and adiponitrile, is described. A process for preparing dintrile compounds obtained by reacting ammonia with an aqueous solution of a dicarboxyl compound in the presence of a silicon orthophosphate catalyst is also described. | 2011-11-24 |
20110288325 | METHOD FOR PRODUCING SILICA-SUPPORTED CATALYST, AND METHOD FOR PRODUCING UNSATURATED CARBOXYLIC ACID OR UNSATURATED NITRILE - Disclosed is a silica-supported catalyst having excellent wear resistance, by which an object product can be obtained with excellent yield. Specifically disclosed is a method for producing a silica-supported catalyst which contains Mo, V, Nb and component X (that is Sb and/or Te), and is used in a vapor-phase catalytic oxidation reaction or vapor-phase catalytic ammoxidation reaction of propane. The method for producing a silica-supported catalyst comprises: (I) a step wherein Mo, V, Nb, component X, a silica sol and water are mixed, thereby preparing a starting material blended solution; (II) a step wherein the starting material blended solution is dried, thereby obtaining a dried powder; and (III) a step wherein the dried powder is tired, thereby obtaining a silica-supported catalyst. In the method for producing a silica-supported catalyst, the silica sol contains 10-270 ppm by weight of nitrate ions relative to SiO | 2011-11-24 |
20110288326 | PROCESS FOR ISOMERIZING CIS-2-PENTENENITRILE TO 3-PENTENENITRILES - A process for isomerizing cis-2-pentenenitrile to 3-pentenenitriles, by isomerizing cis-2-pentenenitrile with amidines, tertiary amines or mixtures thereof as a catalyst at temperatures of 80 to 200° C. and a pressure of 0.01 to 50 bar. | 2011-11-24 |
20110288327 | PROCESS FOR THE MANUFACTURE OF COMPOUNDS COMPRISING NITRILE FUNCTIONAL GROUPS - A method for producing compounds including at least one nitrile function by the hydrocyanation of a compound including at least one non-conjugated unsaturation is described. A method for producing compounds including at least one nitrile function by the hydrocyanation of an organic compound including at least one non-conjugated unsaturation including 2 to 20 carbon atoms by reacting with hydrogen cyanide in the presence of a catalytic system including at least one nickel complex in a zero oxidation state with at least one organophosphorus ligand selected from the group including organophosphites, organophosphonites, organophosphinites and organosphosphines and a co-catalyst such as a Lewis acid consisting of a mixture of Lewis acids is also described. | 2011-11-24 |
20110288328 | METHOD FOR PREPARING TRANS-ACETIC ACID ESTER - A method for preparing a trans-{4-[(alkylamino)methyl]cyclohexyl}acetic acid, which is useful as a raw material compound for manufacture of medicaments and the like, comprising the step of reducing amide group of a compound represented by the following general formula (6) (R | 2011-11-24 |
20110288329 | PROCESS FOR THE PREPARATION OF TRANS 4-AMINO-CYCLOHEXYL ACETIC ACID ETHYL ESTER HCL - The invention relates to a process for the preparation of trans 4-amino-cyclohexil ethyl acetate HCl wherein | 2011-11-24 |
20110288330 | OPTICAL ELEMENT COMPOUND, OPTICAL MATERIAL, AND OPTICAL ELEMENT - An optical material organic compound having characteristics that the dispersion characteristic (Abbe number (ν | 2011-11-24 |
20110288331 | PROCESS FOR THE PREPARATION OF CHOLINE SALT OF FENOFIBRIC ACID AND ITS NOVEL POLYMORPH - The present invention relates to an improved process for the preparation of choline salt of fenofibric acid corresponding to formula (I). The present invention also provides crystalline polymorphic form of choline salt of fenofibric acid corresponding to formula (I) designated as form A. | 2011-11-24 |
20110288332 | AMINOCARBOXYLATE POWDERS WITH IMPROVED PURITY AND FLOWABILITY PROPERTIES - Provided is a method for preparing stable free flowing solid aminocarboxylate chelants by adding to a chelant that contains residual alkaline metal hydroxide a free or partially neutralized carboxylic acid such that the free or partially neutralized acid neutralizes at least a portion of the alkaline metal hydroxide; and isolating therefrom the free-flowing solid chelant. | 2011-11-24 |
20110288333 | Processes for Producing Acetic Acid - Processes for the reduction and/or removal of permanganate reducing compounds (PRC'S) formed by the carbonylation of methanol in the presence of a Group VIII metal carbonylation catalyst to produce acetic acid are disclosed. More specifically, processes for reducing and/or removing PRC's or their precursors from intermediate streams during the formation of acetic acid by said carbonylation processes are disclosed. In particular, processes in which a low boiling overhead vapor stream from a light ends column is subjected to a distillation to obtain an overhead that is subjected to an extraction to selectively remove and/or reduce PRC's from the process is disclosed. The processes include steps of recycling one or more return streams derived from the distillation step and/or the extraction step to a light ends column and/or a drying column in order to improve water control in the overall reaction system. | 2011-11-24 |
20110288334 | REACTOR AND PROCESS FOR PREPARING PHOSGENE - A reactor ( | 2011-11-24 |
20110288335 | Preparation of Hop Acids and their Derivatives - A method for preparing a hop acid mixture having an enantiomeric excess of a (+)-tetrahydro-α-acid is disclosed. In the method, a racemate of a tetrahydro-α-acid is contacted with an amine to form a precipitate having an enantiomeric excess of the (+)-tetrahydro-α-acid. A method for preparing a hop acid is also disclosed. In the method, a racemate of a tetrahydro-α-acid is contacted with an amine to form a precipitate comprising a (+)-tetrahydro-α-acid, and the (+)-tetrahydro-α-acid is isomerized to a hop acid selected from the group consisting of (+)-trans-tetrahydro-iso-α-acids, (−)-cis-tetrahydro-iso-α-acids, and mixtures thereof, and reduced to (+)-trans-hexahydroiso-α-acids and (−)-cis-hexahydroiso-α-acids. An additive for flavoring a malt beverage is also disclosed. The additive includes a bittering agent selected from the group consisting of (+)-trans-tetrahydro-iso-α-acids, (−)-cis-tetrahydro-iso-α-acids, (+)-trans-hexahydroiso-α-acids, (−)-cis-hexahydroiso-α-acids, and mixtures thereof. | 2011-11-24 |
20110288336 | METHOD FOR PRODUCING MEMANTINE - Method for producing 1-amino-3,5-dimethyladamantane or a salt thereof, comprising: (i) heating 1-formamido-3,5-dimethyladamantane with a base in a protic solvent. | 2011-11-24 |