47th week of 2012 patent applcation highlights part 42 |
Patent application number | Title | Published |
20120295275 | Monoclonal Antibodies and Uses Thereof - The technology relates to monoclonal antibodies useful in the identification of cancer cells. In one embodiment, mAbs with specificity for tumor antigens are provided. In one embodiment, methods for treating cancer using mAbs are provided. In another embodiment, methods for detecting cancerous cells are provided. In another embodiment, kits for detecting cancerous cells are provided. | 2012-11-22 |
20120295276 | MASS SPECTRAL ANALYSIS - The invention generally relates to mass spectral analysis. In certain embodiments, methods of the invention involve analyzing a lipid containing sample using a mass spectrometry technique, in which the technique utilizes a liquid phase that does not destroy native tissue morphology during analysis. | 2012-11-22 |
20120295277 | DEVICE AND METHOD FOR DETECTING THE PRESENCE OF HEMOGLOBIN IN A BIOLOGICAL SAMPLE - A device and method for detecting the presence of hemoglobin in a biological sample, more particularly, the presence of blood in a fecal sample as an indicator of upper or lower gastrointestinal tract bleeding. | 2012-11-22 |
20120295278 | FLUORESCENCE DETECTING METHOD, METHOD FOR PRODUCING FLUORESCENT BEADS, AND FLUORESCENT BEADS - Two or more kinds of fluorescent beads containing at least two kinds of basic fluorochromes different in fluorescence intensity, fluorescence wavelength, and fluorescence relaxation time from each other, wherein a content ratio between the at least two kinds of basic fluorochromes and absolute amounts of contents of the basic fluorochromes are set so as to be different between different kinds of fluorescent beads. The fluorescent beads are used in a flow cytometer for fluorescence detection. This makes it possible to identify a greater variety of beads than before with high accuracy in a single measurement. | 2012-11-22 |
20120295279 | PRETREATMENT SOLUTION FOR IMMUNOHISTOCHEMICAL STAINING AND CONDENSED SOLUTION THEREOF - Disclosed are a pretreatment solution for immunohistochemical staining, which elutes a paraffin-containing embedding medium from a glass slide with a tissue specimen embedded in the medium, and retrieves antigenicity of the tissue specimen, and which is usable three or more times, and a pretreatment solution concentrate for immunohistochemical staining which allows ready preparation of the pretreatment solution. The pretreatment solution for immunohistochemical staining contains an antigen retrieving agent, particular nonionic surfactants, and cyclodextrin or a derivative thereof, with the balance being not less than 80 mass % of water. The content of the antigen retrieval agent is such that the pH of the pretreatment solution is in a predetermined range, and the content of cyclodextrin or a derivative thereof is a particular amount. | 2012-11-22 |
20120295280 | CITRULLINATED PEPTIDES FOR DIAGNOSING AND PROGNOSING RHEUMATOID ARTHRITIS - The present invention provides novel citrullinated peptides, their use in methods for aiding, assisting, improving, or facilitating the diagnosis or prognosis of rheumatic diseases such as rheumatoid arthritis (RA), and methods for identifying novel citrullinated peptides that are immunoreactive with anti-citrullinated protein antibodies (ACPAs). The present invention also provides methods for detecting rheumatoid factor (RF) using novel RF detection reagents as a means to aid, assist, improve, or facilitate the diagnosis or prognosis of rheumatic diseases such as RA. Kits comprising at least one of the novel citrullinated peptides and/or RF detection reagents of the present invention are also provided. | 2012-11-22 |
20120295281 | SPECIFIC SALIVARY BIOMARKERS FOR RISK DETECTION, EARLY DIAGNOSIS, PROGNOSIS AND MONITORING OF ALZHEIMER'S AND PARKINSON'S DISEASES - Methods by which specific biomarkers in saliva are used for risk detection, early diagnosis, prognosis and monitoring of Alzheimer's and Parkinson's diseases. | 2012-11-22 |
20120295282 | METHODS OF DIAGNOSING OR TREATING PROSTATE CANCER USING THE ERG GENE, ALONE OR IN COMBINATION WITH OTHER OVER OR UNDER EXPRESSED GENES IN PROSTATE CANCER - The present invention relates to oncogenes or tumor suppressor genes, as well as other genes, involved in prostate cancer and their expression products, as well as derivatives and analogs thereof. Provided are therapeutic compositions and methods of detecting and treating cancer, including prostate and other related cancers. Also provided are methods of diagnosing and/or prognosing prostate cancer by determining the expression level of at least one prostate cancer-cell-specific gene, including, for example, the ERG gene or the LTF gene alone, or in combination with at least one of the AMACR gene and the DD3 gene. | 2012-11-22 |
20120295283 | FLUORESCENT MOLECULAR PROBES FOR USE IN ASSAYS THAT MEASURE TEST COMPOUND COMPETITIVE BINDING WITH SAM-UTILIZING PROTEINS - Assay methods may generally comprise forming homogeneous assay mixtures comprising target SAM-utilizing protein, fluorescent detection analyte, and test compound, incubating, and measuring FP or TR-FRET signal emitted in order to determine a measure of test compound-SAM-utilizing protein binding. Assay mixtures comprise a SAM-utilizing protein, and a fluorescent detection analyte that binds with the SAM-utilizing protein in the absence of test compound. Assay mixtures may further comprise a test compound. Assay mixture embodiments may generate FP or TR-FRET signal properties that are a function of the inherent binding interactions of both the test compound and the detection analyte with the SAM-utilizing protein. Fluorescent detection analytes comprise a fluorophore moiety, a covalent linker moiety, and a SAM-utilizing protein ligand moiety and could be utilized in FP or TR-FRET assays to measure test compound binding. | 2012-11-22 |
20120295284 | Fluorecent Saccharide Conjugates - The present invention relates to improved fluorescently labeled monosaccharide and low molecular weight oligosaccharide conjugates for immunofluorescent staining, confocal microscopic imaging and flow cytometry/fluorescence activated cell sorting (FACS). These fluorophore conjugates target cells, components of cell surfaces and extracellular components; and are useful as probes for tumor targeting and cellular uptake. | 2012-11-22 |
20120295285 | Ordered Assembly of Membrane Proteins During Differentiation of Erythroblasts - Disclosed herein are methods for the isolation, identification, and quantification of red blood cells and red blood cell precursors at different developmental stages. Also disclosed are methods for monitoring ex vivo proliferation and differentiation of red blood cells and red blood cell progenitors. | 2012-11-22 |
20120295286 | Methods for the Diagnosis, Prognosis and Monitoring of Cancer Therapy Using BP1 - The invention described herein relates to method for diagnosing or monitoring the progression of a cancer, e.g., breast cancer, prostate cancer or brain cancer, in a subject by determining the amount of one or more biomarkers in a bodily fluid sample, where the biomarkers comprise pBP1. The invention described herein also relates to method for assessing the efficacy of a treatment of a subject having or suspected of having a cancer, by determining the amount of one or more biomarkers in a bodily fluid sample. | 2012-11-22 |
20120295287 | PREPARING HAPTEN-SPECIFIC ANTIBODIES AND THEIR APPLICATION FOR IMMUNODIAGNOSTICS AND RESEARCH - This document provides methods and materials related to detecting neurotransmitters and other biologically active small molecules. For example, methods for detecting and measuring hapten levels in a biological sample using antibodies specific for conjugated haptens are provided. | 2012-11-22 |
20120295288 | SEROLOGICAL MARKER FOR DETECTING PANCREATIC CANCER AND A METHOD FOR USING THE SEROLOGICAL MARKER - UL16 binding protein 2 (ULBP2) is a protein overexpressed in pancreatic cancer tissues, and the ULBP2 levels are significantly higher in pancreatic cancer patients than those in healthy controls. This invention provides a method to detect pancreatic cancer using ULBP2 as a serological marker. The combination of ULBP2 and CA19-9 promotes the efficacy of pancreatic cancer detection. When measuring the blood ULBP2 levels in patients with other cancer types, including colorectal carcinoma, nasopharyngeal carcinoma and gastric cancer illustrates the blood ULBP2 levels are higher in patients with pancreatic cancer than other cancer types. | 2012-11-22 |
20120295289 | DEVICE AND METHOD FOR CULTURING CELLS - A device and method for culturing cells is described. Culture media is continuously or intermittently delivered to the cell culture for diluting concentration of at least one marker component in the cell culture. The concentration of the marker component may be measured continuously or intermittently to determined the culture media delivery rate. | 2012-11-22 |
20120295290 | MAGNETIC BEADS FOR REDUCING LEUKOCYTE INTERFERENCE IN IMMUNOASSAYS - Methods and devices for reducing interference from leukocytes in an analyte immunoassay are provided. In one embodiment, a method is provided comprising the steps of amending a biological sample with magnetic sacrificial beads opsonized to leukocytes, binding leukocytes in the sample to the magnetic sacrificial beads, and magnetically retaining the beads out of contact from an immunosensor. | 2012-11-22 |
20120295291 | Method for Determining the Risk of Clopidogrel Resistance - The present invention relates to a method for identifying patients for whom there is a high probability of their not benefiting from therapy with clopidogrel. It was found that the thrombocyte activity of a patient makes it possible to establish, even before the intake of clopidogrel, whether the patient has an increased risk of clopidogrel resistance (high on-treatment platelet reactivity). | 2012-11-22 |
20120295292 | Detecting Protein Arginine Deiminase (PAD) Activity in Human Tissues and Sera - Methods for diagnosing disease that is characterized by an overabundance of citrullinated proteins such as colitis, rheumatoid arthritis, and/or malignant cancer in a subject are provided. The PAD protein activity level can be measured in a tissue sample (e.g., serum) of the subject and then compared to a control PAD protein activity range of a control group. A finding of an increased PAD protein activity level in the tissue sample of the subject compared to the PAD protein activity level of the control group is indicative of disease characterized by an overabundance of citrullinated proteins in the subject. | 2012-11-22 |
20120295293 | NOVEL ENHANCED SURFACE AREA CONICO-CYLINDRICAL FLASK (ES-CCF) FOR BIOFILM CULTIVATION - A novel enhanced surface area conico-cylindrical flask (ES-CCF) providing increased surface area by virtue of its' inner arrangement and useful in routine small-scale studies of bioactives production by any biofilm-forming marine as well as terrestrial microorganisms. Compared to corresponding Erlenmeyer flask of similar volume the ES-CCF provides more than 80% additional surface for biofilm attachment and growth. The ES-CCF does not require steam sterilization and is durable as the device is constructed of polymethyl methacrylate or any other such hydrophobic material and offers possibility of altering the nature of the growth surface (hydrophilic and hydrophobic). The ES-CCF also provides external aeration like a bioreactor, thus increasing the versatility of applications. Further, the device can be operated as a cylindrical flask, that is without the inner arrangement. | 2012-11-22 |
20120295294 | ENZYMATIC METHOD FOR PREPARING ASPARTAM - An improved method is described for the synthesis of aspartame using a condensation reaction between the alpha-carboxyl group of the L-aspartic acid and the amino group of the methyl L-phenylalaninate catalyzed by an enzyme. The method allowed efficient and cost effective production of aspartame. A method of identifying an enzyme useful for preparing aspartame is also described. | 2012-11-22 |
20120295295 | DETECTING ISOMERS USING DIFFERENTIAL DERIVATIZATION MASS SPECTROMETRY - Methods of evaluating molecular isomers of branched-chain amino acids are featured. The methods can include: derivatizing one or more molecular isomers of branched-chain amino acids in a sample comprising a branched-chain amino acid labeled with one or more heavy atoms as a first standard; adding, to the sample, after derivatization, a nonderivatized or derivatized branched chain amino acid that is labeled with one or more heavy atoms, as a second standard; evaluating the sample using tandem mass spectrometry; and detecting peaks indicative of derivatized and nonderivatized forms of one or more branched-chain amino acids in the sample. | 2012-11-22 |
20120295296 | Chlorite in the Treatment of Neurodegenerative Disease - The invention features methods of treating a macrophage-associated neurodegenerative disease such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), or multiple sclerosis (MS) in a subject by administering chlorite in an amount effective to decrease blood immune cell activation. The invention also features methods of monitoring therapy by assessing blood immune cell activation before and after therapy. | 2012-11-22 |
20120295297 | ASSAY METHOD USING ENCODED PARTICLE-BASED PLATFORM - Provided is an assay method using an encoded particle-based platform. In the assay method, first, a plurality of encoded particles having codes distinguishable from one another according to kinds of included target materials are prepared. The plurality of encoded particles are provided onto a plate including a plurality of wells by pipetting, and disposed in the plurality of wells by a self-assembly method. An analyte is provided into the plurality of wells. The codes of the plurality of encoded particles disposed in the plurality of wells are decoded. The target materials of the plurality of encoded particles are released to cause a reaction between the target materials and the analyte. | 2012-11-22 |
20120295298 | EX VIVO METHOD FOR DETERMINING POTENTIAL GLP-2 RECEPTOR MODULATORS - Disclosed herein is a method for measuring the contractility of intestinal tissue upon treatment with GLP-2 or a GLP-2 ligand. Also disclosed is an assay which directly measures the activity of GLP-2 or GLP-2 ligands ex vivo and permits the screening of putative GLP-2 ligands in native tissue. | 2012-11-22 |
20120295299 | Method and apparatus for rapidly analyzing microorganisms using petri plates - A growth plate or Petri plate and a method for detection and identification of microorganisms by specific or non-specific staining of colonies or microcolonies is described. Analytical substances (chromogenic or fluorogenic substrates, biochemical dyes, dyes indicators of pH, antibiotics and other biological active substances) are applied to the lower surface of a nutrient agar layer. The substances diffuse in the agar, reach cells and react with them. Because colonies or microcolonies are not removed from the media, they retain their shape, color, size and other useful characteristics for analytical purposes. | 2012-11-22 |
20120295300 | VIABILITY CELL COUNTING BY DIFFERENTIAL LIGHT ABSORPTION - Cell counts that distinguish between live and dead cells while providing an accurate count of the total of live and dead cells are obtained by the use of a vital stain in conjunction with illumination of the cell population and the taking of light images at different wavelengths, one which is not absorbed by the stain and one that is absorbed by the stain. Masking and inaccuracies in the counting of dead cells is thereby avoided. | 2012-11-22 |
20120295301 | FLOATING BACTERIA TRAPPING DEVICE, FLOATING BACTERIA COUNTING METHOD AND FLOATING BACTERIA COUNTING SYSTEM - A floating bacteria counting device capable of trapping floating bacteria in air continuously for a long time without decreasing trapping efficiency even if the time before a trapping carrier being replaced is prolonged and a floating bacteria counting method and a floating bacteria counting system using the floating bacteria trapping device are provided. A nozzle ( | 2012-11-22 |
20120295302 | MAGNETIC SEPARATION OF RARE CELLS - A magnetic separation system configured to separate with high qualitative and quantitative yield magnetized cells from cell mixtures, comprising at least one electromagnet structured to generate a magnetic field flux about a plurality of separation zones and sufficient to attract a majority of the magnetized cells in the mixture, and a pump to drive the cell mixture at a controlled flow rate through a tube disposed within the zones thereby separating a majority of the magnetized cells from the mixture. The system is particularly useful to retrieve rare cells from a fluid mixture of cells having low abundance of the rare cells relative to the rest of the cells while sustaining viability of the cells. | 2012-11-22 |
20120295303 | PHOTOSYNTHETIC ORGANISMS AND CELLS ADAPTED TO METABOLIZE PHOSPHITE AS A SOURCE OF PHOSPHORUS - System, including methods and compositions, for making and using photosynthetic organisms and cells that are adapted transgenically to metabolize phosphite as a source of phosphorus for supporting growth. | 2012-11-22 |
20120295304 | METHOD FOR PRODUCING ALPHA-L-ASPARTYL-L-PHENYLALANINE-BETA-ESTER AND METHOD FOR PRODUCING ALPHA-L-ASPARTYL-L-PHENYLALANINE-ALPHA-METHYL ESTER - A method of producing an α-L-aspartyl-L-phenylalanine-β-ester by forming the α-L-aspartyl-L-phenylalanine-β-ester from L-aspartic acid-α,β-diester and L-phenylalanine using an enzyme or enzyme-containing substance that has an ability to selectively link L-phenylalanine to an α-ester site of the L-aspartic acid-α,β-diester through a peptide bond. | 2012-11-22 |
20120295305 | Cysteine Protease Autoprocessing of Fusion Proteins - Disclosed are fusion proteins, polynucleotides that encode the disclosed fusion proteins, and methods for expressing and autoprocessing of the disclosed fusion proteins to obtain a target protein. The disclosed fusion proteins include an autoproteolytic cysteine protease fused to a heterologous polypeptide, which may be isolated as the target protein. Preferably, the protease activity of the cysteine protease is inducible. Suitable autoproteolytic cysteine proteases for the fusion proteins include the cysteine protease of the | 2012-11-22 |
20120295306 | Modified CIPA Gene From Clostridium Thermocellum for Enhanced Genetic Stability - Bacteria consume a variety of biomass-derived substrates and produce ethanol. The scaffoldin gene cipA from | 2012-11-22 |
20120295307 | PICHIA PASTORIS DEFICIENT IN ENDOGENOUS SECRETED PROTEASE - The present invention relates to micro-organisms and to methods of producing proteins. More specifically, the inventions relates to a host cell useful for the expression of heterozygous proteins in which the host cell, | 2012-11-22 |
20120295308 | CARBOHYDATE BINDING MODULES WITH REDUCED BINDING TO LIGNIN - Provided is a modified Family 1 carbohydrate binding module (CBM) comprising amino acid substitutions at one or more of positions 10, 11, 12, 14, 17, 21, 24, 29, 31, 33, and 37, said position determined from alignment of a Family 1 CBM amino acid sequence with SEQ ID NO: 30, and exhibiting from about 50% to about 99.9% amino acid sequence identity to SEQ ID NO: 30. Also provided are modified glycosidase enzymes comprising the modified Family 1 CBM, genetic constructs and genetically modified microbes for expressing the modified Family 1 CBM or modified glycosidase enzyme. The modified Family 1 CBM confers reduced lignin binding and/or increased hydrolysing activity in the presence of lignin to the modified glycosidase enzyme, which may be used in a process for hydrolysing cellulose or hemicellulose in the presence of lignin. | 2012-11-22 |
20120295309 | BACTERIAL HOST STRAIN COMPRISING A MUTANT SPR GENE AND HAVING REDUCED TSP ACTIVITY - The present invention provides a recombinant gram-negative bacterial cell comprising a mutant spr gene encoding a spr protein having a mutation at one or more amino acids selected from D133, H145, H157, N31, R62, I70, Q73, C94, S95, V98, Q99, R100, L108, Y115, V135, L136, G140, R144 and G147 and wherein the cell has reduced Tsp protein activity compared to a wild-type cell. | 2012-11-22 |
20120295310 | NUCLEIC ACIDS ENCODING ANTI-IL-23 ANTIBODIES - The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17, IL-23 via it's p19 subunit or both IL-17 and IL-23 (via p19). IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease. | 2012-11-22 |
20120295311 | Methods and Materials for Nucleic Acid Manipulation - The present invention is concerned with the field of nucleic acid manipulation and particularly DNA manipulation, and uses thereof. Specifically, the invention pertains to methods involving the joining of nucleic acids and uses of such joined nucleic acids, for example for creating transformed microorganisms. Also, the invention pertains to materials useful in such methods. | 2012-11-22 |
20120295312 | ROTATIONAL PCR EQUIPMENT AND PCR METHOD USING THE SAME - A rotational PCR apparatus, a PCR chip for the same and a rotational PCR method using the same. | 2012-11-22 |
20120295313 | PROCESS FOR PRODUCING GRANULES - The present invention pertains to processes for preparing granules comprising cellulose-containing fibers and biocomposites comprising disintegrated fibers, granules and biocomposites produced by the processes of the invention, as well as uses of said granules in methods for producing biocomposites comprising disintegrated fibers. | 2012-11-22 |
20120295314 | METHOD FOR PRODUCING MONATIN - The present invention provides a method of producing 2R,4R-Monatin with a good yield using inexpensive L-Trp rather than expensive D-Trp as a stating material. Specifically, the present invention provides a method for producing 2R,4R-Monatin or a salt thereof, comprising:
| 2012-11-22 |
20120295315 | Nucleic acid encoding a cobalamin-dependent methionine synthase polypeptide - The present invention relates to nulceotide sequences encoding enzymatically active cobalamin-methionine synthase and functional fragments thereof being modified in comparison to the respective wild-type enzyme such that said enzymes show reduced product inhibition by methionine. The present invention also relates to polypeptides being encoded by such nucleotide sequences and host cells comprising such nucleotide sequences. Furthermore, the present invention relates to methods for producing methionine in host organisms by making use of such nucleotide sequences. | 2012-11-22 |
20120295316 | PROCESS FOR PREPARATION OF TACROLIMUS - Genetically modified strains of | 2012-11-22 |
20120295317 | Processes and Recombinant Microorganisms for the Production of Cadaverine - The present invention relates to the use of recombinant microorganisms comprising DNA molecules in a deregulated form which improve the production of cadaverine, as well as to recombinant DNA molecules and polypeptides used to produce the microorganism, said microorganism comprising an intracellular lysine decarboxylase activity and an enhanced lysine import activity or comprising an intracellular and an extracellular lysine decarboxylase activity or comprising an intracellular and extracellular lysine decarboxylase activity and an enhanced lysine import activity. The present invention also relates to a processes for the production of cadaverine using recombinant microorganisms. | 2012-11-22 |
20120295318 | CYCLOPROPENONES AND THE PHOTOCHEMICAL GENERATION OF CYCLIC ALKYNES THEREFROM - Cyclic alkynes (e.g., cyclooctynes such as dibenzocyclooctynes) can be photochemically generated from cyclopropenones as disclosed herein. The cyclic alkynes can be reacted (e.g., in situ) with materials having alkyne-reactive groups (e.g., azide groups in a “click” reaction). In preferred embodiments, the generation and reaction of the cyclic alkyne can proceed in the absence of a catalyst (e.g., Cu(I)). These reactions can be useful, for example, for the selective labeling of living cells that are metabolically modified with azido-containing surface monosaccharides, or for light-directed surface patterning. | 2012-11-22 |
20120295319 | Method of Modifying a Yeast Cell for the Production of Ethanol - The invention relates to a method of modifying a yeast cell for the production of ethanol. According to the invention, the activity of the Gpd1 protein and/or the Gpd2 protein is reduced. | 2012-11-22 |
20120295320 | APPARATUS AND METHOD FOR TREATMENT OF MICROORGANISMS DURING PROPAGATION, CONDITIONING AND FERMENTATION USING STABILIZED CHLORINE DIOXIDE/SODIUM CHLORITE WITH HOPS ACID EXTRACTS - A method of reducing undesirable microorganism concentration, promoting desirable microorganism propagation/conditioning, and increasing desirable microorganism efficiency in an aqueous fluid stream includes (a) introducing a quantity of fermentable carbohydrate, sugar or cellulose to an aqueous fluid stream, (b) introducing a quantity of desirable microorganism to the aqueous fluid stream, (c) introducing a stabilized sodium chlorite solution into the aqueous fluid stream and (d) introducing a hops acid extract into said aqueous fluid stream. An apparatus for the same comprising a stabilized sodium chlorite batch tank, a hops acid extract tank and a process vessel wherein introducing stabilized sodium chlorite and hops acid extract solution from the batch tank and the hops acid extract tank to the process vessel promotes propagation of producing microorganisms present in the vessel. | 2012-11-22 |
20120295321 | Pentose Transporters and Uses Thereof - The invention relates to the production of biofuels, proteins, peptides and other value-added compounds from crude carbon sources. The inventors identified genes encoding novel pentose transporters, in particular transporters of L-arabinose and/or D-xylose. Regulation of the | 2012-11-22 |
20120295322 | METHOD OF PRODUCING LYCOPENE USING RECOMBINANT ESHERICHIA COLI - A method of producing lycopene, with high productivity by means of a recombinant bacterial strain includes preparing the recombinant vector containing genes encoding proteins, which are required for lycopene biosynthesis. The genes involved in lycopene biosynthesis are crtE, crtB and crtI, and at least one of the said three genes (crtE, crtB and crtI) is selected from the group consisting of crtE with the SEQ ID NO:1, crtB with the SEQ ID NO:3 and crtI with the SEQ ID NO:5, of the Sequence List. The said recombinant vector is transformed into | 2012-11-22 |
20120295323 | Inactivation of Proteases - The invention relates to a process for inactivating proteases by repeatedly changing the pH in the cell culture supernatant at the start of the process for the purification of biopharmaceuticals. The pH is adjusted first to 3-5, and then to 7-9. | 2012-11-22 |
20120295324 | OVERPRODUCTION OF LIGNINOLYTIC ENZYMES - Methods, compositions, and systems for overproducing ligninolytic enzymes from the basidiomycetous fungus are described herein. As described, the method can include incubating a fungal strain of | 2012-11-22 |
20120295325 | FIREFLY LUCIFERASE, ITS GENE, AND METHOD FOR PRODUCING FIREFLY LUCIFERASE - A firefly luciferase having the amino acid sequence of firefly luciferase, wherein the amino acid corresponding to position 287 of Heike firefly luciferase is replaced with alanine, or wherein the amino acid corresponding to position 392 is replaced with isoleucine. The firefly luciferase has improved thermostability and storage stability. A firefly luciferase gene coding for the firefly luciferase. By utilizing this gene, it is possible to efficiently produce firefly luciferase with increased stability. It is also possible to obtain firefly luciferase with further increased stability by combination with a mutation in which the amino acid at position 326 is replaced with serine, and/or a mutation in which the amino acid at position 467 is replaced with isoleucine. | 2012-11-22 |
20120295326 | LUCIFERASES AND METHODS FOR MAKING AND USING THE SAME - Briefly described, embodiments of this disclosure include polynucleotides that encode mutant | 2012-11-22 |
20120295327 | Targeted Therapeutic Proteins - Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic agent and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor. Nucleic acids, cells, and methods relating to the practice of the invention are also provided. | 2012-11-22 |
20120295328 | METHOD FOR ISOLATING SMALL RNA - A method for isolating small RNA from a sample is provided, the method comprising binding the RNA to silica particles by contacting the sample with a) at least one alcohol, b) at least one chaotropic salt comprising a chaotropic anion selected from the group consisting of trichloroacetate, perchlorate and trifluoroacetate and c) silica particles and separating the bound RNA from the rest of the sample. The present invention also provides compositions and kits to efficiently isolate small RNA molecules from samples, in particular biological samples such as blood, blood products tissue and body fluids. | 2012-11-22 |
20120295329 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES SHOW IMPROVED CATALYTIC ACTIVITY AND CHIRAL SELECTIVITY - This invention provides novel chemically modified mutant serine hydrolases that catalyze a transamidation and/or a transpeptidation and/or a transesterification reaction. The modified serine hydrolases have one or more amino acid residues in a subsite replaced with a cysteine, wherein the cysteine is modified by replacing the thiol hydrogen in the cysteine with a substituent group providing a thiol side chain comprising a moiety selected from the group consisting of a polar aromatic substituent, an alkyl amino group with a positive charge, and a glycoside. In particularly preferred embodiments, the substitutents include an oxazolidinone, a C | 2012-11-22 |
20120295330 | Methods Of Intracellular Conversion Of Single-Chain Proteins Into Their Di-Chain Form - The present specification discloses expression constructs comprising single-chain proteins comprising a di-chain loop region comprising an exogenous protease cleavage site and a protease that can cleave the exogenous protease cleavage site located within the di-chain loop, cell compositions comprising such expression construct, and intracellular methods of converting the single-chain protein into its di-chain form. | 2012-11-22 |
20120295331 | Savinase Variants Having An Improved Wash Performance on Egg Stains - Subtilase variants having an improved wash performance on egg stains. These subtilases are useful exhibiting excellent or improved wash performance on egg stains when used in e.g. cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions. | 2012-11-22 |
20120295332 | SYSTEMS AND METHODS FOR DELIVERING OXYGEN TO A VESSEL - Oxygen is delivered into a liquid contained within a vessel. Oxygen-rich gas is introduced at an inner mixing region of a vessel toward an agitating element for dissolving some of the oxygen into the liquid. Air is introduced to the liquid at a location different from where the oxygen-rich gas is introduced, minimizing coalescing of bubbles of the oxygen-rich gas and air bubbles. Running the agitating element in the vessel may induce mixing of the liquid and improve oxygen dissolution. Movement of the air bubbles can also generate a mixing effect on the liquid, yet independent from mixing caused by the agitating element. In some embodiments, currents produced by the agitating element are asymmetric with respect to a vertical axis of the vessel. Air bubbles may also form an asymmetric configuration of bubbles about the vertical axis. | 2012-11-22 |
20120295333 | SYSTEMS AND METHODS FOR PRODUCING A GAS DISPERSION IN A BIOLOGICAL SUBSTANCE IN A DISPOSABLE VESSEL - Biological liquid substances in a disposable bioreactor or a disposable fermentor is enriched with a dissolved gas such as oxygen. The gas is provided to the liquid in meeting growth needs of biomass within the disposable vessel. The liquid is processed through a bubble forming element such as a supersonic mixer, a membrane sparger, or the like, to form a gas-liquid dispersion. The dispersion has a high interfacial surface area for facilitating gas dissolution in the liquid. Receptacles of the disposable vessel may be coupled (e.g., magnetically) to one or more processing devices (e.g., motors, pumps, gas sources) outside of the disposable vessel so that components within the disposable vessel are able to perform functions suitable for furthering reaction and/or fermentation processes. | 2012-11-22 |
20120295334 | METHOD FOR THE OXYGENATION OF FERMENTATIONS USING OXYGEN AND AIR OR OTHER OXYGEN REDUCING GASES - An improved fermentation device and method uses a combination of substantially pure Oxygen as the Oxygenation gas and a separate air (or other Oxygen reducing gas) purge through the headspace of a fermentation device. The air injection and air purge vent line are configured to maintain a backpressure within the headspace. The air purge permits improved oxygen utilization and increases safety through dilution and removal of ammonia gas emitted during fermentation. | 2012-11-22 |
20120295335 | PREVENTION OF CONTAMINATION OF NUTRIENT FEED RESERVOIRS & FEED LINES IN BIOREACTOR - A method to prevent contamination of feed line(s) and nutrient feed reservoirs(s) is disclosed. In this method the growth medium which flows from the nutrient feed reservoir through the feed line to the bioreactor contains at least one nutritional component supplied at a concentration which is inhibitory to cell growth. The inhibitory nutritional component in the growth medium prevents back growth of cells from the bioreactor into the feed line(s). The growth medium with inhibitory nutritional component is diluted in the bioreactor. | 2012-11-22 |
20120295336 | Microalgae Cultivation System for Cold Climate Conditions - A system and method are provided for growing microalgae in cold climate areas. The system includes an expanding Plug Flow Reactor with a plurality of ponds used to grow algae by mixing a culture fluid with a nutrient. To minimize the loss of heat due to environmental factors, the expanding Plug Flow Reactor is covered with a translucent, light-transmitting cover and is lined with an insulation liner. In addition, an underground sump and pump are provided and connected to the expanding Plug Flow Reactor. The sump is provided to store the algae at night when ambient air temperature is at its coldest. An adjacent power plant provides: (1) heat byproducts to warm the culture and (2) CO | 2012-11-22 |
20120295337 | ALGAE CULTURE SYSTEM - A microalgae culture system that provides greater control of a culture due to distribution and the shape of its components. The system allows for the possibility to incorporate gases into the medium, resulting in an increased culture yield and lower energy consumption per unit volume. The system generally includes a pool with a circular mantle, PVC parts and a removable lid. | 2012-11-22 |
20120295338 | MONITORING SYSTEMS FOR BIOMASS PROCESSING SYSTEMS - A sensor array is disclosed that includes a conduit having a lumen extending between an inlet and an outlet of the conduit. The sensor array can include a plurality of sensors coupled to the conduit. Each sensor can have a probe member that is disposed within the lumen. The sensors can be configured to measure at least one parameter of an aqueous medium containing a biomass. | 2012-11-22 |
20120295339 | Method and Apparatus for Detection, Analysis, and Collection of Rare Cellular Events - Systems and methods for the detection, analysis, and collection of rare cellular events, wherein rare cellular events are defined by events comprising less than 5% of a total number of cells in a sample. The systems and methods generally include: (1) a flow cell dimensioned so as to permit a flow of a sample through the flow cell at a flow rate greater than 300,000 cells per second; (2) a laser positioned to emit a laser beam directed to the flow cell; (3) one or more deflector components disposed between the laser and the flow cell, wherein the deflector component is configured to affect a position of the laser beam relative to the sample flow; (4) one or more fluorescence emission detectors; and (5) one or more processor configured to detect rare cellular events based on fluorescence emission from cell-binding surface markers introduced into the sample prior to the sample being flowed through the flow cell. | 2012-11-22 |
20120295340 | SEPARATION AND CONCENTRATION OF BIOLOGICAL CELLS AND BIOLOGICAL PARTICLES USING A ONE-DIMENSIONAL CHANNEL - This document discloses, among other things, a method and system for a substrate having a bypass region for fluid flow. The substrate includes a plurality of fluid flow channels with each channel configured to concurrently allow fluid flow while precluding passage of a target particle or object. | 2012-11-22 |
20120295341 | THERMAL TREATMENT APPARATUS AND FLUID TREATMENT METHOD WITH FLUIDIC DEVICE - A thermal treatment apparatus includes a fluidic device including at least one channel, a first temperature-changing unit that changes the temperature of a fluid in part of the channel, and a second temperature-changing unit that changes the temperature of the fluid in another part of the channel. The temperature changes by the first and second temperature-changing units cause at least any one of the expansion and contraction of the fluid in the respective parts of the channel, and the at least any one of the expansion and contraction of the fluid due to the first temperature-changing unit is offset by the at least any one of the expansion and contraction of the fluid due to the second temperature-changing unit. | 2012-11-22 |
20120295342 | PREVENTION OF CONTAMINATION OF FEED RESERVOIRS & FEED LINES IN BIOREACTOR SYSTEMS - A method to prevent contamination of feed line(s) and nutrient feed reservoir(s) is disclosed. In this method a heated zone is established in the feed line close to the location where the feed line connects to the bioreactor. The heated zone prevents back growth of cells from the bioreactor back into the feed line and further into the feed reservoir. | 2012-11-22 |
20120295343 | CLOSURE ASSEMBLY FOR CELL CULTURE APPARATUS - A closure assembly for a cell culture apparatus includes a port and a snap cap. The port has an annular sidewall defining an opening in communication with a cell culture chamber of a cell culture apparatus. The sidewall has (i) external threads for cooperating with internal threads of a twist cap and (ii) an annularly protruding snap cap engagement feature. The snap cap has a top and an annular sidewall extending from the top. The sidewall of the snap cap has an inwardly annularly projecting element configured to engage with the annularly protruding snap cap engagement feature of the port such that, when fully engaged, the snap cap is not readily removed from the port by unaided human force. | 2012-11-22 |
20120295344 | Stem Cell Fusion Model of Carcinogenesis - Model systems and methods for exploring mechanisms of carcinogenesis and the acquisition of metastatic ability, and to provide insights into potential therapeutic targets. The systems include and methods involve fusion of a stem cell and a genetically altered cell to evaluate carcinogenesis and metastasis and for the discovery and evaluation of new therapeutic targets to inhibit metastasis and other markers of carcinogenesis. | 2012-11-22 |
20120295345 | APPARATUSES AND RELATED METHODS FOR DELIVERING BIOLOGICAL MATERIAL INTO A CELL - Systems, devices, and methods for protecting a biological material during delivery into a biological structure are provided. In one aspect, for example, a device for protecting and delivering a preselected biological material into a biological structure can include a lance operable to maintain a charge capable of associating a biological material thereto and at least one protective region formed on or in the lance, where the protective region protects the biological material during delivery into a biological structure. | 2012-11-22 |
20120295346 | METHODS AND COMPOSITIONS FOR MODULATING MEMBRANE POTENTIAL TO INFLUENCE CELL BEHAVIOR - The present invention provides methods for controlling proliferation, differentiation, and/or migration of cells by modulating membrane potential through an endogenously expressed channel protein. The present invention also provides methods for identifying candidate instructor cells, as well as therapeutic agents that are useful for modulating (e.g., promote or inhibit) proliferation and differentiation, as well as promoting regeneration of a desired tissue type. | 2012-11-22 |
20120295347 | Methods and Compositions for Producing Endothelial Progenitor Cells from Pluripotent Stem Cells - Aspects of the present invention are drawn to methods and compositions for producing endothelial progenitor cells (EPCs) in vitro from pluripotent stem cells and compositions containing such EPCs. The methods produce sufficient EPCs to use in therapeutic applications. In certain embodiments the EPCs are bipotent, giving rise to both vascular and lymphatic endothelial cells. In certain embodiments, EPCs express one or more of the following gene products: LYVE-1, PV-1/PAL-E, CD31, and CD34. | 2012-11-22 |
20120295348 | METHOD FOR PROLIFERATING STEM CELLS BY ACTIVATING C-MET/HGF SIGNALING AND NOTCH SIGNALING - The present invention relates to stem cells in which a gene that activates signaling is introduced and to a method for proliferating the stem cells. More specifically, the invention relates to a method of significantly increasing the ability of stem cells to proliferate, either by transfecting stem cells with the Notch intracellular domain (NICD) to activate the Notch signaling pathway, or by transfecting stem cells with the c-MET gene and treating the transfected stem cells with the HGF ligand protein to activate the c-MET/HGF signaling pathway. According to the present invention, as a result of activating the Notch signaling pathway or the c-MET/HGF signaling pathway, stem cells having an excellent ability to proliferate can be produced in large amounts. Particularly, since neural stem cells which have been difficult to culture in vitro can be proliferated in large amounts, thus the neural stem cells will be more useful for the preparation of cell therapeutic agents for treating cranial nerve diseases. | 2012-11-22 |
20120295349 | MAMMAL DEDICATED CELL LINE FROM HUMAN HEPATOCELLULAR CARCINOMA CELL - A mammal dedicated cell line is provided, which is a HepG2 hepatocellular carcinoma cell line (HepG2/NF-kB/Luc/sr39tk)1_18 obtained by co-transformation with NF-kB/Luc and NF-kB/sr39tk. Firstly, a successfully transformed pNF-kB/Luc HepG2 cell is obtained. Then, a dedicated cell line sensitive to TPA and MTX is generated by experimental screening Next, a plasmid construct carrying pNF-kB/sr39tk genome is introduced into the dedicated cell line by means of Superfect protocol. Finally, a HepG2 cell line co-expressing NF-kB/Luc and NF-kB/sr39tk is screened with G418 and ZEOCIN, and transformation result is confirmed by luminescence and radio activity. The (HepG2/NF-kB/Luc/sr39tk)1_18 obtained is suitable to screen drug for treating liver cancer and examine these cells by bioluminescence imaging and nuclear medicine imaging. | 2012-11-22 |
20120295350 | Prospective Identification and Characterization of Breast Cancer Stem Cells - The invention provides methods for treating cancer via administering to a patient having a solid tumor a therapeutically effective amount of an antibody against Delta-like ligand 4(D114) or other Notch pathway components. The solid tumor may comprise solid tumor stem cells. | 2012-11-22 |
20120295351 | METHOD FOR CLONING PLURIPOTENT STEM CELLS - Embodied herein are methods of reprogramming somatic cells or tissue stem cells to a more multipotent state or even a pluripotent state, the methods do not involve gene transfer of master transcription factor genes/proteins. The methods are also useful for rapid and efficient cloning of induced pluripotent stem cells after gene transfer of master transcription factor genes/proteins. | 2012-11-22 |
20120295352 | Systems and Methods for Expanding High Density Non-Adherent Cells - Embodiments described herein generally relate to systems and methods for promoting the expansion of high density non-adherent cells through the use of a cell growth chamber, a mass transfer device, and a fluid circulation loop. Improved cell growth is achieved in the cell growth chamber by using a chamber having a particular orientation and shape, e.g., conical, to create a media-rich reservoir for growing cells. By placing the chamber in a vertical position, the force of media flow along the chamber walls is substantially equal and opposite to the gravitational force on the cells. The interaction of these forces maintains the non-adherent cells in suspension. The use of the cell growth chamber in conjunction with the mass transfer device and fluid circulation loop(s) creates efficiencies by relying on the cumulative and combined features of the devices. | 2012-11-22 |
20120295353 | METHODS OF MAKING AND USING POLYMERS AND COMPOSITIONS - Disclosed are methods of making and using polymers compositions. The polymer compositions may have monomer/oligomer mixtures that may have at least one silicone monomer or oligomer and at least one non-silicone monomer or oligomer, at least one crosslinker, and/or at least one polymerization initiator. The polymer compositions are cured, after which they may be useful in bioapplications, such as for use as freestanding films or coatings on a substrate, such as a mold, for cell culture. | 2012-11-22 |
20120295354 | SULFONYLUREA-RESPONSIVE REPRESSOR PROTEINS - Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell. | 2012-11-22 |
20120295355 | NUCLEIC ACID DELIVERY USING MODIFIED CHITOSANS - The present invention is directed to the delivery of nucleic acids in a non-viral vector to cells by positively charged chitosan derivatives, including but not limited to chitosan-arginine, chitosan-lysine and chitosan-histidine. | 2012-11-22 |
20120295356 | APPARATUS AND METHOD FOR GENETICALLY TRANSFORMING CELLS - A fluid containing cells and free genetic material is acoustically coupled to a propulsion surface of a diaphragm. A blast-receiving surface of the diaphragm is acoustically coupled to an explosion chamber in which an explosive material is disposed. An ignition system ignites the explosive material in the explosion chamber to create a blast wave. The diaphragm transfers momentum from the blast wave to the fluid containing cells and free genetic material sufficient to cause the cells to take up the free genetic material. | 2012-11-22 |
20120295357 | APPARATUS AND METHOD FOR QUANTIFYING BINDING AND DISSOCIATION KINETICS OF MOLECULAR INTERACTIONS - The present invention relates to an apparatus for quantifying the binding and dissociation kinetics of molecular interactions of small molecular bio materials with high sensitivity almost without the influence of a change in the reflective index resulting from a buffer solution by making polarized incident light incident on the binding layer of a bio material, formed in a thin dielectric film, so that the polarized incident light satisfies a p-wave non-reflecting condition and a quantifying method using the same. | 2012-11-22 |
20120295358 | Magnetic Conveyor Systems, Apparatus and Methods Including Moveable Magnet - Disclosed are magnetic conveyor systems and apparatus having a magnetic coupling with a housing and moveable magnet therein. The moveable magnet is substantially constrained in one dimension and adapted to move in another. The moveable magnet is adapted to magnetically couple with an attracting portion of a sample rack and move the rack along a conveying surface. Ease of transfer of sample racks is provided while minimizing spillage from the open sample containers therein. Method of operating the conveyor system are provided, as are other aspects. | 2012-11-22 |
20120295359 | AUTOMATED METHOD AND APPARATUS FOR DETECTING ERRONEOUS SAMPLE COLLECTION IN CLINICAL ASSAYS - An automatic method for identifying biological samples that are collected using the wrong blood preservative for subsequent analytical testing. The method also provides for identification and/or suppression of certain analytical test results that are substantially or partly adversely affected. The invention is particularly suited for use in point-of-care medical diagnostic testing. | 2012-11-22 |
20120295360 | METHOD AND APPARATUS FOR DETERMINING RADIATION - The present invention relates to devices, systems, and methods for determination of ionizing radiation. In some embodiments, the devices comprise nanocomposite materials containing nanostructures (e.g., carbon nanotubes) dispersed in radiation sensitive polymers. In some cases, the device may include a conductive pathway that may be affected upon exposure to ionizing radiation. Embodiments described herein may provide inexpensive, large area, low power, and highly sensitive radiation detection materials/devices. | 2012-11-22 |
20120295361 | MEASURING LEVELS OF A METABOLITE - Described herein are methods for determining an amount of an analyte in a test sample. The methods involve preparing a calibration curve using standard samples containing an isotopically-labeled standard in a biological matrix. | 2012-11-22 |
20120295363 | MATERIAL AND METHOD FOR TRAPPING, DETECTING AND QUANTIFYING HETEROCYCLIC AROMATIC COMPOUNDS AND OTHERS - What is provided includes a porous sol-gel material whose intrinsic pH is lower than 1 and comprising at least one probe molecule chosen from the group consisting of croconic acid, p-dimethyl-aminobenzaldehyde (DMABA), p-dimethyl aminocinnamaldehyde (DMACA), p-methoxybenzaldehyde (MOB) and 4-methoxy-1-naphtaldehyde (MON). In addition, a detection system containing the porous sol-gel material and a method of preparation and use of the porous sol-gel material for trapping and/or detecting and optionally quantifying at least one chemical compound such as indole and indole compounds are provided. | 2012-11-22 |
20120295364 | PHOTOLUMINESCENT PRESSURE PROBE - A self-contained, remotely interrogatable, autonomously positionable, pressure probe and methods of manufacturing and using. The probe ( | 2012-11-22 |
20120295365 | FUEL PROPERTY DETERMINATION METHOD AND FUEL PROPERTY DETERMINATION DEVICE - A fuel property determination method includes a reaction mechanism analysis process (S1) of analyzing elementary reactions that compose chemical reactions between a plurality of types of initial materials including the materials that compose the fuel and obtaining the elementary reactions as fuel elementary reactions, and an octane number determination process (S2) of calculating the combustion characteristics of the fuel by performing a simulation based on the fuel elementary reactions and determining the octane number based on the combustion characteristics of the fuel. | 2012-11-22 |
20120295366 | DIAGNOSTIC SYSTEM - The invention relates to a device for contactless control of magnetic beads on a microfluidic card by means of external magnetic fields, without having to use complicated mechanics or hydraulics. Based on a modulation of the gradient of a magnetic field, magnetic beads are lifted in a first step in a contactless way out of different reaction chambers of the microfluidic card. By means of a translation movement or a variation or modulation of the gradient of a magnetic field, horizontal transport of the magnetic beads over a mechanical barrier of the microfluidic card is facilitated in a second step. It is possible in a third step to use a further modulation of the gradient of the magnetic field to lower the magnetic beads into a desired further fluid zone. | 2012-11-22 |
20120295367 | COMPOSITION AND METHOD FOR ANALYSIS OF TARGET ANALYTES - A method of detecting first and second analytes includes providing a mixture containing first analytes and second analytes; adding microparticles of a first size coated with first competitive inhibitors that compete with the first analytes for binding to first antibodies to the first analytes, and adding microparticles of a second size coated with second competitive inhibitors that compete with the second analytes for binding to first antibodies to the second analytes, adding second antibodies specific to the first antibodies to the first analytes and second antibodies specific to the first antibodies to the second analytes, wherein the second antibodies specific to the first antibodies to the first analytes are labeled with a first fluorescent moiety, and the second antibodies specific to the first antibodies to the second analytes are labeled with a second fluorescent moiety | 2012-11-22 |
20120295368 | KITS FOR DETECTING TARGET MATERIAL AND METHODS OF DETECTING TARGET MATERIAL USING THE KITS - Kits for detecting a target material and methods of detecting a target material by using the kits are provided, the kits include a target material binding portion including a first molecule and a probe linked to the first molecule, and a target material detection portion including a plurality of nanoparticles each having a surface to which a compound having a zwitterion and a second molecule are linked. The first molecule is specifically bound to the second molecule in a pair. | 2012-11-22 |
20120295369 | METHOD FOR DETERMINATION OF AGGREGATES - A method of determining aggregates of a macromolecule monomer in a fluid containing the macromolecule, comprises the steps of:
| 2012-11-22 |
20120295370 | MAGNETIC RANDOM ACCESS MEMORY (MRAM) WITH ENHANCED MAGNETIC STIFFNESS AND METHOD OF MAKING SAME - A STTMRAM element has a free sub-layer with enhanced internal stiffness. A first free sub-layer is made partially of boron (B), annealing is performed of the STTMRAM element at a first temperature to reduce the B content at an interface between the first free sub-layer and the barrier layer, the annealing causing a second free sub-layer to be formed on top of the first free sub-layer and being made partially of B, with an amount greater than the amount of B in the first free sub-layer. The STTMRAM element is cooled to a second temperature that is lower than the first temperature and a third free sub-layer is deposited directly on top of the second free layer, with the third free sub-layer being made partially of boron B. The amount of B in the third sub-free layer is less than the amount of B in the second free sub-layer. | 2012-11-22 |
20120295371 | Process for Reconditioning Semiconductor Surface to Facilitate Bonding - A non-abrading method to facilitate bonding of semiconductor components, such as silicon wafers, that have micro structural defects in a bonding interface surface. In a preferred method, micro structural defects are removed by forming an oxide layer on the bonding interface surface to a depth below the level of the defect, and then removing the oxide layer to expose a satisfactory surface for bonding, thereby increasing line yield and reducing scrap triggers in fabrication facilities. | 2012-11-22 |
20120295372 | METHOD OF MASKLESS MANUFACTURING OF OLED DEVICES - By the invention it is proposed a method of manufacturing of an OLED-device, comprising the steps of providing a carrier substrate, depositing a first electrode material layer on said carrier substrate, forming electrically separated areas within the deposited first electrode material layer, depositing a layer of an organic optoelectronic active material ( | 2012-11-22 |
20120295373 | METHOD OF MANUFACTURING NITRIDE SEMICONDUCTOR LIGHT EMITTING ELEMENT - To provide a method of manufacturing a nitride semiconductor light emitting element, which has a small number of steps and thus, can improve productivity, the method of manufacturing a nitride semiconductor light emitting element including a nitride semiconductor light emitting element structure having an n-type nitride semiconductor layer and a p-side nitride semiconductor layer which are laminated on a substrate, an n-side pad electrode connecting surface and a p-side pad electrode connecting surface which are formed on the same plane of the substrate; a n-side pad electrode on the n-side pad electrode connecting surface; and a p-side pad electrode on the p-side pad electrode connecting surface, and in the manufacturing method, a pad electrode layer forming step, a resist pattern forming step, a pad electrode layer etching step, a protective layer forming step and a resist pattern removing step are sequentially performed. | 2012-11-22 |
20120295374 | LIGHT EMITTING DEVICE, PACKAGE, LIGHT EMITTING DEVICE MANUFACTURING METHOD, PACKAGE MANUFACTURING METHOD AND PACKAGE MANUFACTURING DIE - A light emitting device includes a resin molded body having a circular or an oval recessed section at the center suppresses generation of cracks. The device is provided with a light emitting element, a first resin molded body having a plurality of outer surfaces, and a recessed section at the center. First and second leads are electrically connected to the light emitting element, and a second resin molded body is applied in the recessed section. The light emitting element is placed on the first lead, and the surface of the second resin molded resin forms a light emitting surface. A gate notch is formed on an extended line of a normal line on one point on a circular cross-section of the recessed section in the normal line direction. | 2012-11-22 |
20120295375 | PEELING METHOD AND METHOD FOR MANUFACTURING DISPLAY DEVICE USING THE PEELING METHOD - The present invention provides a simplifying method for a peeling process as well as peeling and transcribing to a large-size substrate uniformly. A feature of the present invention is to peel a first adhesive and to cure a second adhesive at the same time in a peeling process, thereby to simplify a manufacturing process. In addition, the present invention is to devise the timing of transcribing a peel-off layer in which up to an electrode of a semiconductor are formed to a predetermined substrate. In particular, a feature is that peeling is performed by using a pressure difference in the case that peeling is performed with a state in which plural semiconductor elements are formed on a large-size substrate. | 2012-11-22 |