46th week of 2010 patent applcation highlights part 40 |
Patent application number | Title | Published |
20100291584 | MICROFLUIDIC IMAGING CYTOMETRY - A microfluidic system has a pipette system comprising a plurality of pipettes, a microfluidic chip arranged proximate the pipette system, an imaging optical detection system arranged proximate the microfluidic chip, and an image processing system in communication with the imaging optical detection system. The microfluidic chip has a plurality of cell culture chambers defined by a body of the microfluidic chip, each cell culture chamber being in fluid connection with an input channel and an output channel defined by the microfluidic chip. The pipette system is constructed and arranged to at least one of inject fluid through the plurality of pipettes into the plurality of input channels or extract fluid through the plurality of pipettes from the plurality of output channels while the microfluidic system is in operation. | 2010-11-18 |
20100291585 | METHODS AND COMPOSITIONS FOR DIAGNOSING COMPLICATIONS OF PREGNANCY - The present invention provides methods and compositions for identifying subjects at risk of developing a complication of pregnancy, such as preeclampsia or preterm labor. The compositions are microRNAs and associated nucleic acids. | 2010-11-18 |
20100291586 | METHOD FOR THE DIAGNOSIS OR THE SCREENING OF AN ARBOVIRUS INFECTION, REAGENTS USEFUL IN SAID METHOD AND THEIR APPLICATIONS - Method for the diagnosis or the screening of an arbovirus infection and preferably a flaviviridae infection and more preferably a flavivirus infection, reagents useful in said method and their applications. Said method comprises: (i) contacting a sample from the subject or animal with a solid support sensitized with an Ig binding protein which is directed against a specific class of Ig molecules of the subject or animal species under consideration and (ii) incubating the immunocomplex formed in (i) with a detector molecule consisting of a hybrid protein comprising at least an arboviral ED3 domain and an alkaline phosphatase (PhoA), the detection of said immunocomplex being the sign of the presence of an arbovirus in said sample. | 2010-11-18 |
20100291587 | BIOMARKER FOR DIAGNOSING HEART DISEASE AND THE USE THEREOF - The invention relates to the following methods [1] to [3] and to a kit for carrying out the methods: | 2010-11-18 |
20100291588 | SYSTEMS AND METHODS INCLUDING SELF-CONTAINED CARTRIDGES WITH DETECTION SYSTEMS AND FLUID DELIVERY SYSTEMS - Methods, systems, and apparatus for detecting the presence of analytes are described. A fluid or gas sample may pass through a microsieve-based detection system and/or a particle-based detection system of a cartridge. Detection and analysis techniques may be applied to determine the identity and quantity of the captured analytes. | 2010-11-18 |
20100291589 | COMBINATION THERAPY FOR THE TREATMENT OF DIABETES AND CONDITIONS RELATED THERETO AND FOR THE TREATMENT OF CONDITIONS AMELIORATED BY INCREASING A BLOOD GLP-1 LEVEL - The present invention concerns combination of an amount of a GPR119 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a blood glucose level or in increasing a blood GLP-1 level in a subject over that provided by the amount of the GPR119 agonist or the amount of the DPP-IV inhibitor alone and the use of such a combination for treating or preventing diabetes and conditions related thereto or conditions ameliorated by increasing a blood GLP-1 level. The present invention also relates to the use of a G protein-coupled receptor to screen for GLP-1 secretagogues. | 2010-11-18 |
20100291590 | METHODS FOR THE DIAGNOSIS AND THE PROGNOSIS OF A BRAIN TUMOR - The present invention relates to methods for the diagnosis of a brain tumor and for the estimation of a prognosis for patients having a brain tumor using the presence/absence of a particular IDH1 mutation as a marker. | 2010-11-18 |
20100291591 | NOVEL PLATING MEDIA - Plating media contains enzyme substrates (ES) used to detect enzyme activity associated with a target organism and that include a binding motif (BM) that serves to bind detectable enzymes (DE) (also called marker enzymes in this disclosure). A signalogenic substructure (SG) produces detectable signals and an enzyme labile group (ELG) is labile to the action of a marker enzyme and it typically includes the binding motif. The enzyme labile group links to the signalogenic substructure via a labile bond (LB) which is cleaved by the action of the marker enzyme separating the signalogenic substructure and the enzyme labile group. In some embodiments a linker is inserted between the signalogenic substructure and the enzyme labile group. Presence of the enzyme and thus the organism is detected by presence of a fluorogenic, precipitate that can be detected in single colonies. | 2010-11-18 |
20100291592 | NOVEL MARKER FOR SENSITIVITY AGAINST SULFONAMIDE COMPOUND - The sensitivity of a tumor cell to a sulfonamide compound or the anti-tumor effect of a sulfonamide compound can be examined by determining the expression level of EGFR1 in the tumor cell and employing the variation in the EGFR1 expression level as a measure. Thus, a method for determination of the sensitivity of a tumor cell to a sulfonamide compound; a method for determination of the anti-tumor effect of a sulfonamide compound; and a test kit for use in these methods are provided. | 2010-11-18 |
20100291593 | METHOD OF IDENTIFYING DIAGNOSTIC REAGENTS - Disclosed herein are methods for identifying diagnostic reagents (e.g., antigen-binding molecules, such as antibodies) that are useful, for instance, as primary diagnostic, prognostic, and/or predictive (e.g., companion diagnostic) reagents in a disease state, such as cancer. | 2010-11-18 |
20100291594 | ErbB Surface Receptor Complexes as Biomarkers - The invention is directed to a new class of biomarker in patient samples comprising dimers of ErbB cell surface membrane receptors. In one aspect, the invention includes a method of determining the status of a disease or healthful condition by correlating such condition to amounts of one or more dimers of ErbB cell surface membrane receptors measured directly in a patient sample, in particular a fixed tissue sample. In another aspect, the invention includes a method of determining a status of a cancer in a specimen from an individual by correlating measurements of amounts of one or more dimers of ErbB cell surface membrane receptors in cells of the specimen to such status, including presence or absence of a pre-cancerous state, presence or absence of a cancerous state, prognosis of a cancer, or responsiveness to treatment. Preferably, methods of the invention are implemented by using sets of binding compounds having releasable molecular tags that are specific for multiple components of one or more types of receptor dimers. After binding, molecular tags are released and separated from the assay mixture for analysis. | 2010-11-18 |
20100291595 | BLOOD MONOCYTE CD163 EXPRESSION AS A BIOMARKER IN HIV-1 INFECTION AND NEUROAIDS - The invention provides a method for detecting CD163+/CD16+ cell population in peripheral blood mononuclear cells in a biological sample from a subject infected with HIV-1 which comprises contacting the biological sample with an anti-CD163 antibody, so that levels of CD163+/CD16+ peripheral blood mononuclear cells in the biological sample can be quantified. The method of the present invention is particularly useful for monitoring the course of HIV-1 infection and/or HIV Encephalopathy | 2010-11-18 |
20100291596 | SCREENING METHOD FOR AGENTS SUITABLE FOR THERAPY OF ALZHEIMER'S DISEASE - Described is a method of screening for therapeutic agents for the prophylaxis and therapy of Alzheimer's disease (AD), wherein agents that (i) do not interfere with the biological activity of gamma-secretase, (ii) do not exhibit cytotoxicity, (iii) lead to reduced amounts of Abeta42 and (iv) are capable of binding to an APP-GxxxG motif thereby weakening or inhibiting dimerization of the APP transmembrane sequence are suitable for prophylaxis or treatment of AD. | 2010-11-18 |
20100291597 | SECRETOGRANIN AND VGF PEPTIDE BIOMARKERS AND USES THEREOF - Secretogranin II and VGF peptides are biomarkers for major depressive disorder. They are useful in methods of diagnosing, monitoring and screening. | 2010-11-18 |
20100291598 | PRION ELISA - Assays for detecting PrP | 2010-11-18 |
20100291599 | LARGE AREA SCANNING APPARATUS FOR ANALYTE QUANTIFICATION BY SURFACE ENHANCED RAMAN SPECTROSCOPY AND METHOD OF USE - Raman spectra of protein immunoblots or enzyme linked immunosorbant assay procedures are acquired with a scanning Raman spectrometer. The sensitivity of the measurement is increased by conjugating secondary antibodies used in the Western blot and ELISA methods to surface enhanced Raman Scattering (SERS) labels. The resulting blot or well plate is analyzed with a Raman system that has forms a pixel map of the sample. More specifically, the Raman system generates an effectively line-shaped illumination pattern and scans the sample in the direction perpendicular to the line while the signal is accumulating on the detector. Each pixel is therefore a rectangle defined by the length of the illumination and the distance traveled by the sample within the duration of signal accumulation on the detector. The pixels are sequentially acquired to generate a map of the sample. | 2010-11-18 |
20100291600 | Immunoassay - The present invention provides an immunoassay method for detecting or determining the amount of salvinorin A, salvinorin B and/or analogues thereof in an in vitro sample, an antibody for salvinorin A, salvinorin B and/or analogues thereof and a kit for detecting the presence of or determining the amount of salvinorin A, salvinorin B and its analogues thereof in a sample. | 2010-11-18 |
20100291601 | CARBOHYDRATE BINDING MODULE AND USE THEREOF - The present invention relates to an antibody mimetic of carbohydrate binding module (CBM) which specifically binds to an epitope on HIV glycoprotein. The present invention also relates to a method of detecting HIV glycoprotein. | 2010-11-18 |
20100291602 | CLINICAL DIAGNOSIS OF HEPATIC FIBROSIS USING A NOVEL PANEL OF LOW ABUNDANT HUMAN PLASMA PROTEIN BIOMARKERS - The inventors have proposed a novel panel of human plasma protein biomarkers for diagnosing hepatic fibrosis and cirrhosis. Presently there is no reliable non-invasive way of assessing liver fibrosis. A 2D-PAGE based proteomics study was used to identify potential fibrosis biomarkers. Plasma from patients with hepatic cirrhosis induced by infection with the hepatitis C virus (HCV) were analysed. Several proteins associated with liver scarring and potentially also related to viral infection were identified. These proteins include 14-3-3 protein zeta/delta, adiponectin, afamin, alpha-1-antitrypsin, alpha-2-HS-glycoprotein, apolipoprotein C-III, apolipoprotein E, C4b-binding protein beta chain, intact/cleaved complement C3dg, corticosteroid-binding globulin, fibrinogen gamma chain, beta haptoglobin at pH 5.46-5.49, haptoglobin-related protein, hemopexin, immunoglobulin J chain, leucine-rich alpha-2-glycoprotein, lipid transfer inhibitor protein, retinol-binding protein 4, serum paraoxonase/arylesterase 1, sex hormone-binding globulin and zinc-alpha-2-glycoprotein. These biomarkers can be used in conjunction with polypeptides in WO/2008/031051. The concentrations of these novel biomarkers can be determined using an immunoassay where the concentrations would reflect the extent of fibrosis. A fibrosis scoring scale for each of the novel biomarkers is proposed. The additive result from the scores of all the novel biomarkers would give a more reliable indication of the degree of fibrosis rather than examining individual biomarkers. | 2010-11-18 |
20100291603 | ASSESSING BLOOD COMPONENTS - This document relates to methods and materials involved in assessing blood components (e.g., assessing von Willebrand factor activity or platelet activity) in mammals. For example, methods and materials involved in using labeled platelets to assess von Willebrand factor activity in a sample (e.g., plasma) from a mammal (e.g., a human) are provided. | 2010-11-18 |
20100291604 | PREDICTIVE TREATMENT OF DYSGLYCEMIC EXCURSIONS ASSOCIATED WITH DIABETES MELLITUS - A predictive technique for treating diabetes mellitus is described whereby a patient's blood glucose levels are monitored “continuously” over an extended period of time and a life-event diary is maintained records all significant life-events (e.g., food intake, medication, exercise, mood/emotions, etc.). This information is analyzed to derive a mathematical model that closely matches the patient's glucose level variations for the period of monitoring. Specific daily time periods of dysglycemic vulnerability are determined by calculating when the mathematical model predicts that crossings of predetermined hyperglycemic and hypoglycemic threshold levels will occur. These predicted periods of vulnerability are then used to devise a therapeutic plan that administers treatment in anticipation of predicted dysglycemic excursions, thereby limiting the extent of those excursions or eliminating them altogether. | 2010-11-18 |
20100291605 | ASSAYS FOR S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASES - Disclosed are novel methyltransferase assay methods, comprising: including, in a reaction mixture for a methyltransferase activity, a purified or recombinant adenosine nucleosidase activity that catalyses release of an adenine or adenine derivative moiety from a transmethylation product, and a purified or recombinant adenine deaminase activity that catalyses deamination of the released moiety to hypoxanthine or respective derivative and ammonia, wherein the methyltransferase activity is rate-limiting; and determining the methyltransferase activity by spectrophotometric or chromatographic monitoring of the coupled deamination reaction products, or of subsequent enzymatic or chemical reactions coupled thereto. Coupled oxidation of the hypoxanthine to uric acid and hydrogen peroxide is optionally affected using purified or recombinant xanthine oxidase, wherein the methyltransferase activity is rate-limiting, and wherein determining the methyltransferase activity comprises monitoring of the coupled oxidation reaction. Variations are disclosed comprises monitoring of reaction products (e.g., to detect NH3, Hypoxanthine, H2O2, and Uric Acid). | 2010-11-18 |
20100291606 | SCREENING SYSTEM FOR DETECTING INHIBITORS OF HIV INTEGRASE-LEDGF/p-75 INTERACTION - The development and validation of a cell-based, homogeneous high throughput screening (HTS) assay for small compounds inhibiting the HIV integrase-LEDGF/p75 interaction is described herein. The HTS strategy has the potential to identify small-molecules interfering with the interaction of HIV integrase-LEDGF/p75. These small molecules represent starting scaffolds for therapeutic drug development. | 2010-11-18 |
20100291607 | TRANSFORMED CELL WITH ENHANCED SENSITIVITY TO ANTIFUNGAL COMPOUND AND USE THEREOF - The present invention provides a transformed cell in which a polynucleotide having a nucleotide sequence encoding an amino acid sequence of an osmosensing histidine kinase having no transmembrane region is introduced in a functional form into a cell deficient in at least one hybrid-sensor kinase, a method of assaying the antifungal activity of a test substance using the transformed cell, and a method of searching an antifungal compound using the method, and the like. | 2010-11-18 |
20100291608 | NOVEL GTP CYCLOHYDROLASE TYPE IB - This invention relates to a novel, bacterial GTP Cyclohydrolase Type IB enzyme, and the crystal structure thereof. | 2010-11-18 |
20100291609 | Reducing Optical Interference in a Fluidic Device - This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications. In particular, the medical device reduces interference with an optical signal which is indicative of the presence of an analyte in a bodily sample. | 2010-11-18 |
20100291610 | Regulating Stem Cells - A composition of matter is provided, comprising a population of cultured cells that comprises a sub-population of cells that both stain as CD31Bright and demonstrate uptake of Ac-LDL+, and secrete IL-8. A method is also provided, comprising stimulating in vitro an initiating cell population (ICP) of at least 5 million cells that have a density of less than 1.072 g/ml, wherein at least 1% of the cells of the ICP is CD34+CD45−/Dim, and at least 25% of the cells of the ICP are CD31Bright, to differentiate into a progenitor/precursor cell population (PCP). Other embodiments are also described. | 2010-11-18 |
20100291611 | Assays - A device includes a substrate that defines, at least in part, a microfluidic network including an inlet in communication with a first detection zone and with a second detection zone. A cobalt reagent and a nickel reagent are disposed within the microfluidic network. First electrodes are in communication with the first detection zone and second electrodes arc in communication with the second detection zone. The device is configured to receive a blood derived sample introduced to the inlet, partition the blood sample into first and second blood sample portions, form a first mixture including at least some of the first blood sample portion and at least some of the cobalt reagent, and form a second mixture including at least some of the second blood sample portion, at least some of the cobalt reagent and at least some of the nickel reagent. | 2010-11-18 |
20100291612 | Peptide Markers for Diagnosis of Preeclampsia - The present invention relates to a method for detecting preeclampsia, comprising determining the expression level of calcyclin in chorionic villi. The invention further relates to a marker for detecting preeclampsia wherein said marker is calcyclin. | 2010-11-18 |
20100291613 | Method of Positioning an Organic, Biological and/or Medical Specimen - The invention relates to a method of positioning an organic, biological and/or medical specimen in a desired partial region of a specimen carrier, comprising the steps arrangement of a gel in a partial region of the specimen carrier, polymerisation or gelification of the gel, by means of which a polymerised gel is obtained, whereby the polymerised gel at least partially, in particular horizontally, delimits the desired partial region and introduction of the specimen into the specimen carrier, in particular into the desired partial region of the specimen carrier. | 2010-11-18 |
20100291614 | IN VITRO METHOD FOR DETERMINING THE RISK OF AND DIAGNOSIS OF AN ARTERIAL VASCULAR DISORDER - An in vitro method is disclosed for (i) determining the risk to an individual of developing an arterial vascular disorder, or (ii) diagnosing an arterial vascular disorder. In at least one embodiment, the method includes at least the following: (a) determining at least one biomarker characteristic of a vascular disorder and/or an early stage of an inflammation in a biological sample of an individual, (b) determining the state of a vessel displayed using an imaging method, wherein the information obtained in (a) and (b) is correlated with (i) or (ii). | 2010-11-18 |
20100291615 | System and method for automatically venting and sampling a culture specimen container - Apparatus for automated venting and/or sampling of a specimen container having a closure sealing the interior of the specimen container from the environment is disclosed. The apparatus includes a rack holding the specimen container; a venting and/or sampling device having a needle, a chamber in fluid communication with the needle and a port in fluid communication with the chamber; a robotic transfer mechanism moveable relative to the rack; a sample removal apparatus attached to the robotic transfer mechanism having gripping features for gripping the venting device. The sample removal apparatus and robotic transfer mechanism are moveable relative to the specimen container so as to automatically insert the needle of the venting device through the closure of the specimen container to thereby vent the interior of the specimen container and obtain equilibrium between the interior of the specimen container and the atmosphere and withdraw a portion of the sample from the specimen container into the venting and/or sampling device. | 2010-11-18 |
20100291616 | NOVEL GENES, COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION AND THERAPY OF CERVICAL CANCER - The invention relates to newly discovered nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are provided. | 2010-11-18 |
20100291617 | RAPID DETECTION OF VOLATILE ORGANIC COMPOUNDS FOR IDENTIFICATION OF MYCOBACTERIUM TUBERCULOSIS IN A SAMPLE - In various embodiments, the invention relates to a method for identifying the presence of particular bacteria in a sample. The method includes collecting a sample that includes or has been exposed to the particular bacteria and detecting, in the sample, at least one volatile organic compound indicative of the presence of the bacteria. | 2010-11-18 |
20100291618 | Methods for rapid identification and/or characterization of a microbial agent in a sample - A method of testing a specimen sample contained within a sealed specimen container. A test sample is removed from the specimen container with a disposable sampling device. Non-microbial agent components of the test sample are lysed, thereby producing a lysed sample. The lysed sample is delivered to a disposable separation device. A microbial agent present in test sample is concentrated within the disposable separation device. The concentrated microbial agent is interrogated, e.g., spectroscopically. | 2010-11-18 |
20100291619 | Combined detection instrument for culture specimen containers and instrument for identification and/or characterization of a microbial agent in a sample - A detection instrument determines whether a specimen container (e.g., blood culture bottle) is positive for presence of microbial agent growth therein. When the container is deemed positive it is made available (e.g, transferred or exposed to) to an automated instrument performing identification and/or characterization of the microbial agent. The identification and/or characterization instrument removes a portion of the sample from the specimen container and places it into a disposable separation and concentration device. The microbial agent is concentrated via optional selective lysis of non-microbial agent cellular material which may be present and centrifugation. A reading module reads the concentrated microbial agent using spectroscopic methods, e.g., measurements of intrinsic fluorescence. Such interrogation may occur while the microbial agent remains concentrated in the disposable device. | 2010-11-18 |
20100291620 | BIO-FUEL PRODUCTION SYSTEM - A biological material production system having an enclosure; a plant advancer located within th enclosure, the plant advancer configured to move one or more plants from a first position to a second position in a predetermined path; and at least one harvester positionable proximate the second position and configured to remove at least a portion of the one or more plants from the plant advancer. A biofuel production system having a biological material production system a harvesting device configured to harvest the biological material as the biological material matures, at least a portion of the harvesting system being substantially within the enclosure, the harvesting system configured to extract liquid from the biological material; a fermenting device proximate the harvesting system and configured to accept and ferment the liquid from the harvesting system; and a distillation device proximate the fermenting device and configured to distill the fermented liquid. | 2010-11-18 |
20100291621 | ANAEROBIC PROCESS - An anaerobic process uses a continuous oscillatory flow reactor ( | 2010-11-18 |
20100291622 | NOVEL COMPOUND, PROCESS FOR PRODUCTION THEREOF, AND USE THEREOF - The present invention provides compounds which exhibit an inhibitory effect on undecaprenyl diphosphate synthase of microbes and thereby they are expected to be used clinically as pharmaceutical agents for infectious diseases caused by bacteria. | 2010-11-18 |
20100291623 | PROCESS FOR PRODUCING ALPHA-GLYCOSYLATED DIPEPTIDE AND METHOD OF ASSAYING ALPHA-GLYCOSYLATED DIPEPTIDE - The present invention relates to a method for producing α-glycated dipeptide, which comprises causing protease to act on N-terminal-glycated peptide or N-terminal-glycated protein. The present invention further relates to a method for determining the amount of α-glycated dipeptide, which comprises causing a fructosyl peptide oxidase to act on the α-glycated dipeptide obtained by the above method and then determining the amount of the thus generated hydrogen peroxide. According to the present invention, a method for producing α-glycated dipeptide is provided, which enables the simple, rapid, and efficient production of α-glycated dipeptide from glycated protein or glycated peptide. Furthermore, according to the present invention, a method for determining the amount of α-glycated dipeptide is provided, which enables to determine the amount of α-glycated dipeptide in a highly precise manner within a short time period. | 2010-11-18 |
20100291624 | COMPOSITIONS AND METHODS FOR IMPROVED GLYCOPROTEIN SIALYLATION - The present invention provides compositions and methods for the production of glycoproteins with enhanced sialylation. In particular, the invention provides cell lines comprising disrupted sialidase expression and methods of using the cell lines to produce glycoproteins with enhanced sialylation. | 2010-11-18 |
20100291625 | REGULATION OF TRANSLATION OF HETEROLOGOUSLY EXPRESSED GENES - The present invention pertains to a method of expressing a protein of interest, preferably a heterologous protein, in preferably a plant. In a preferred embodiment said plant is a doubled haploid homozygous transgenic | 2010-11-18 |
20100291626 | ENHANCED EXPRESSION AND STABILITY REGIONS - Expression-enhancing nucleotide sequences for expression in eukaryotic systems are provided that allow for enhanced and stable expression of recombinant proteins in eukaryotic cells. Enhanced expression and stability regions (EESYRs) are provided for expression of a gene of interest in a eukaryotic cell. Chromosomal loci, sequences, and vectors are provided for enhanced and stable expression of genes in eukaryotic cells. | 2010-11-18 |
20100291627 | METHOD FOR PRODUCTION OF ANTIBODY - The present invention provides a method of producing a recombinant antibody efficiently and at low cost. | 2010-11-18 |
20100291628 | Cells in which activity of the protein involved in transportation of GDP-fucose is reduced or lost - A cell in which the activity of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body is more decreased or deleted than its parent cell; a process for producing an antibody composition using the cell; a transgenic non-human animal or plant or the progenies thereof, in which genome is modified so as to have a decreased or deleted activity of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body; a process for producing an antibody composition from the animal or plant; and a medicament comprising the antibody composition. | 2010-11-18 |
20100291629 | USE OF DELEUCOCYTATION FILTERS FOR DEFENSIN PURIFICATION - The invention concerns the use of deleucocytation filters for defensin purification. More precisely, the invention concerns a method for purifying defensins, including the following steps: passing a blood sample on a deleucocytation filter; detaching the cells retained on the deleucocytation filter, inducing exocytosis of the defensins by those cells. | 2010-11-18 |
20100291630 | METHOD FOR PRODUCING A FOAMING AGENT - A method for producing a foaming agent is provided, the method comprising cultivating a host cell in a fermentation medium wherein the host cell extra-cellularly secretes a foaming agent and wherein the fermentation medium contains an antifoam which has a cloud point; and then removing the antifoam5 while the temperature of the fermentation medium is above the cloud point. | 2010-11-18 |
20100291631 | Novel Beta-Galactoside-Alpha 2,3-Sialyltransferase, a Gene Encoding Thereof, and a Method for Producing Thereof - The present invention provides a novel β-galactoside-α2,3-sialyltransferase and a nucleic acid encoding the sialyltransferase. The present invention also provides a microorganism producing the sialyltransferase, as well as a method for producing the sialyltransferase using such a microorganism. The present invention further provides a vector carrying a nucleic acid encoding the sialyltransferase, and a host cell transformed with the vector, as well as a method for producing a recombinant β-galactoside-α2,3-sialyltransferase. The present invention further provides a method for preparing a sialylsugar chain, which uses the sialyltransferase of the present invention. | 2010-11-18 |
20100291632 | Method for the production of cladribine - A method for producing cladribine (2-chloro-2′-deoxyadenosine) comprising the steps of: | 2010-11-18 |
20100291633 | METHOD OF CLONING AT LEAST ONE NUCLEIC ACID MOLECULE OF INTEREST USING TYPE IIS RESTRICTION ENDONUCLEASES, AND CORRESPONDING CLONING VECTORS, KITS AND SYSTEM USING TYPE IIS RESTRICTION ENDONUCLEASES - The present invention refers to methods of (sub)cloning at least one nucleic acid molecule of interest. One embodiment relates to a method of (sub)cloning at least one nucleic acid molecule of interest comprising a) providing at least one (replicable) Entry vector into which the at least one nucleic acid molecule of interest is to be inserted, wherein the at least one Entry vector carries two recognition sites for at least one first type IIS and/or type IIS like restriction endonuclease and wherein said at least one nucleic acid molecule of interest can be excised from the at least one Entry vector at two combinatorial sites with one (same) or more (different) cohesive ends that are formed by the at least one first type IIS or type IIS like restriction endonuclease, and b) providing an Acceptor vector, into which the at least one nucleic acid molecule of interest is transferred from the at least one Entry vector carrying the at least one nucleic acid molecule of interest, wherein said Acceptor vector comprises at least one recognition site for at least one second type IIS restriction endonuclease and/or at least one recognition sites for at least one type IIS like restriction endonuclease, and wherein said Acceptor vector provides two combinatorial sites identical to the two combinatorial sites present in the Entry vector. The inventions also relates respective cloning vector and kits. | 2010-11-18 |
20100291634 | Annealing control primer and its uses - The present invention relates to an annealing control primer for improving annealing specificity in nucleic acid amplification and its applications to all fields of nucleic acid amplification-involved technology. The present primer comprises (a) a 3′-end portion having a hybridizing nucleotide sequence substantially complementary to a site on a template nucleic acid to hybridize therewith; (b) a 5′-end portion having a pre-selected arbitrary nucleotide sequence; and (c) a regulator portion positioned between said 3′-end portion and said 5′-end portion comprising at least one universal base or non-discriminatory base analog, whereby said regulator portion is capable of regulating an annealing portion of said primer in association with annealing temperature. | 2010-11-18 |
20100291635 | CHIMERIC PRIMERS FOR IMPROVED NUCLEIC ACID AMPLIFICATION REACTIONS - Methods are provided for amplification of a nucleic acid sequence. The method use RNA/DNA chimeric oligonucleotides as primers. The primers have RNA residues scattered along their length and no two ribonucleotides in the prime are adjacent to one another. The methods are useful for reducing non-specific amplification products, such as primer dimers. The invention also provides kits comprising RNA/DNA chimeric oligonucleotide primers for practicing the amplification methods. | 2010-11-18 |
20100291636 | METHOD FOR INTRODUCING COMMON AND/OR INDIVIDUAL SEQUENCE ELEMENTS IN A TARGET NUCLEIC ACID MOLECULE - The invention relates to a method for introducing common and/or individual sequence elements in a target nucleic acid molecule in a sample containing sample nucleic acid molecules, comprising the steps: i) denaturing the sample nucleic acid molecules, if the sample nucleic acid molecules are double-stranded, to obtain single stranded sample nucleic acid molecules; ii) bringing the sample nucleic acid molecules in contact with primary, secondary and tertiary probe nucleic acid molecules, wherein the 3′-end of the tertiary probe comprise a part complementary to the primary probe and the 5′-end of the tertiary probe comprise a part complementary to a 5′-part of the target nucleic acid molecule; the 3′-end of the secondary probe is complementary to a 3′-part of the target nucleic acid molecule and the 5′-end of the secondary probe is not complementary to the target nucleic acid molecule; wherein said primary, secondary and tertiary probes comprise said common and/or individual sequence elements; iii) ligating the 3′-end of the primary probe to the 5′-end of the target nucleic acid molecule; and iv) elongating the 3′-end of the secondary probe by means of a nucleic acid polymerase; or iv′) elongating the 3′-end of the target nucleic acid molecule. | 2010-11-18 |
20100291637 | METHOD FOR MODIFYING NUCLEOTIDE CHAIN - A method for modifying a nucleotide chain, which includes: allowing a catabolic enzyme specific to a nucleotide sequence containing a specific base such as hypoxanthine (Hx) to act on a nucleotide chain (I) to be modified having the above described nucleotide sequence containing a specific base on the 3′-terminal side thereof; and forming a functional group (for example, an aldehyde group) capable of binding to a desired modifier (for example, NH | 2010-11-18 |
20100291638 | THERMOSTABLE DNA POLYMERASES AND METHODS OF USE - Thermostable viral and microbial polymerases exhibiting a combination of activities selected from proofreading (3′-5′) exonuclease activity, nick translating (5′-3′) nuclease activity, synthetic primer-initiated polymerase activity, nick-initiated polymerase activity, reverse transcriptase activity, strand displacement activity, terminal transferase activity, primase activity, and/or efficient incorporation of chain terminating analogs. Some of the polymerases provided herein include a first motif and a second motif. The first motif preferably has the sequence X | 2010-11-18 |
20100291639 | Chemical cavitation and cleaning process - Cavitation is an often used mechanism for accelerating chemical reactions and for cleaning purposes. This invention describes a very simple process for generating cavitation with a vibration table through vertical excitations which generates a “water hammer” that generates very effective cavitation. A simple example is given for an industrial application of this process—splitting cellulose via sulfuric acid to glucose. | 2010-11-18 |
20100291640 | PROCESS FOR PREPARING URETHANE-CONTAINING (METH)ACRYLIC ESTERS - A process for preparing urethane-containing (meth)acrylic esters (U) by reacting a urethane-containing alcohol (A) with a (meth)acrylic ester of a saturated alcohol (G) in the presence of at least one polymerization inhibitor (P) with an enzyme (E) as a catalyst in a reactor, wherein
| 2010-11-18 |
20100291641 | PROCESS FOR CONTINUOUSLY PREPARING URETHANE-CONTAINING (METH)ACRYLIC ESTERS - A process for preparing urethane-containing (meth)acrylic esters (U) by reacting a urethane-containing alcohol (A) with a (meth)acrylic ester of a saturated alcohol (G) in the presence of at least one polymerization inhibitor (P) with an enzyme (E) as a catalyst in a reactor, wherein the (meth)acrylic ester of a saturated alcohol (G) and the urethane-containing alcohol (A) are passed continuously through at least one fixed bed reactor filled with an immobilized enzyme (E) as a catalyst. | 2010-11-18 |
20100291642 | Process For Preparing Dipeptidyl Peptidase IV Inhibitors And Intermediates Therefor - A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structure | 2010-11-18 |
20100291643 | METHOD FOR PRODUCING ENATIONMERICALLY PURE D-PPT - A method of producing enantimoerically pure D-Phosphinothricin (D-PPT) by providing a mixture of D and L PPT, N-acetylating L-PPT and then recovering and purifying D-PPT. | 2010-11-18 |
20100291644 | PROCESS FOR PREPARING METHACRYLIC ACID OR METHACRYLIC ESTERS - The present invention relates to a process for the preparation of methacrylic acid or methacrylic esters, comprising the process steps of
| 2010-11-18 |
20100291645 | XYLOSE REDUCTASE MUTANTS AND USES THEREOF - Engineered mutant xylose reductases demonstrate higher preference to xylose than arabinose. Amino acid mutations were engineered in to native xylose reductase from | 2010-11-18 |
20100291646 | Process for the Recovery of a Fermentation Product - The present invention provides a process for the purification and concentration of a partially water-soluble organic product from a source containing the same at concentration C0, which process comprises the steps of: (i) concentrating said product by means of a resin to form a first aqueous solution at concentration of C1; and (ii) fractionating an aqueous solution by temperature adjustment to form a second aqueous solution and a third aqueous solution with concentrations C2 and C3, respectively, wherein C2>C3 and C2>C1>C0. | 2010-11-18 |
20100291647 | Microorganisms Having Enhanced Resistance To Acetate And Related Compositions And Methods of Use - The present invention provides isolated or genetically modified strains of microorganisms that display enhanced resistance to acetate as a result of increased expression of a sodium proton antiporter. The present invention also provides methods for producing such microbial strains, as well as related promoter sequences and expression vectors. Further, the present invention provides methods of producing alcohol from biomass materials by using microorganisms with enhanced resistance to acetate. | 2010-11-18 |
20100291648 | Global transcription machinery engineering - The invention relates to global transcription machinery engineering to produce altered cells having improved phenotypes. | 2010-11-18 |
20100291649 | CONTROL OF CONTAMINANT YEAST IN FERMENTATION PROCESSES - A fermentation process for the production of ethanol from natural sources, such as corn, comprising introducing a fermentable sugar, an inoculant yeast, and a stabilized chlorine dioxide into a fermentation system is disclosed. The stabilized chlorine dioxide is added preventatively to the fermentation system to substantially prevent growth of contaminating microorganisms such as contaminant yeast. | 2010-11-18 |
20100291650 | Methods for reducing enzyme consumption in second generation bioethanol fermentation in the presence of lignin. - Provided are methods of liquefaction, saccharification and fermentation of pre-treated lignocellulosic biomass in production of bioethanol. Addition of PEG or surfactant is effective to enhance cellulase hydrolysis yields at high dry matter (>20%) at surprisingly low concentrations compared with comparable results in low dry matter hydrolysis. This effect is most pronounced at comparatively low cellulase loading <7 FPU (g DM) | 2010-11-18 |
20100291651 | RECOMBINANT HYDROGEN-PRODUCING CYANOBACTERIUM AND USES THEREOF - A recombinant cyanobacterium comprising an oxygen-tolerant, hydrogen-evolving hydrogenase, kit, and methods of use. | 2010-11-18 |
20100291652 | YEAST STRAINS AND METHODS OF MAKING AND USING SUCH YEAST STRAINS - The present disclosure provides genetically-modified yeast that are able to produce more ethanol and less glycerol than yeast lacking the corresponding genetic modifications. The approaches described herein involve disrupting the ability of the yeast to produce and/or transport glycerol and increasing the amount of a polypeptide involved in maintaining the redox balance of the yeast cell. | 2010-11-18 |
20100291653 | BIOTRANSFORMATION USING GENETICALLY MODIFIED CANDIDA - A substantially pure | 2010-11-18 |
20100291654 | PREPARATION FOR PHOTODYNAMIC CONTROL OF MICROORGANISMS AND USE THEREOF - The invention relates to a preparation for the photodynamic control of micro-organisms, said preparation being in a liquid or pasty form and containing a photosensitiser which comprises a dyestuff and produces singlet oxygen when irradiated by means of light. The micro-organisms can be marked by means of the dyestuff. The aim of the invention is to improve said preparation in order to enable an improved photodynamic control. To this end, the preparation contains an active ingredient for amplifying or weakening the oxidative action of the singulet oxygen by chemical manipulation of the dyestuff or the nanoenvironment thereof. In a particular form of embodiment, a rinsing solution is used before the irradiation. | 2010-11-18 |
20100291655 | NOVEL GLUCOSE DEHYDROGENASE AND METHOD FOR PRODUCING THE DEHYDROGENASE - A novel glucose dehydrogenase, which is an enzyme that has high substrate specificity, can be produced at a low cost, is not affected by oxygen dissolved in a measurement sample and, in particular, has superior thermal stability is obtained by culturing a microorganism belonging to the genus | 2010-11-18 |
20100291656 | METHOD AND SYSTEM FOR PROTEIN PURIFICATION - The present invention provides a method and a system for protein purification using a starch binding protein (SBP)-tagged recombinant protein. SBP-binding matrixes are also disclosed in the invention to recover the SBP-tagged recombinant protein. Thus, purifying a target protein is re-usable, convenient and low cost by the present invention. | 2010-11-18 |
20100291657 | RIBONUCLEASES IN WHICH AN AMINO ACID SEQUENCE OF A KNOWN RIBONUCLEASE IS PRECEDED BY AT LEAST ONE RESIDUE AT THE N-TERMINUS, AND METHODS OF MAKING THEM RECOMBINANTLY - New RNases, and methods of making them, are disclosed. Each includes an amino acid sequence that is disclosed in U.S. Pat. No. 6,239,257 B1, but that is preceded by a different N-terminus residue or leader sequence. | 2010-11-18 |
20100291658 | PROCESS FOR SEPARATING NONPROTEINANEOUS BIOMOLECULES, IN PARTICULAR NUCLEIC ACIDS, FROM PROTEINANEOUS SAMPLES - The present invention relates to method of isolating non-protein-containing biomolecules, in particular nucleic acids, characterized in that protein degradation is carried out on a solid phase. | 2010-11-18 |
20100291659 | Methods and Apparatuses for Reducing Emissions of Volatile Organic Compounds from Pumps and Storage Tanks for Voc-Containing Fluids - A method is provided for reducing emissions of a volatile organic compound (“VOC”) from a source of the VOC. The method includes the steps of: (A) operatively positioning a VOC-absorbing material between the source of the VOC and the atmosphere, wherein the VOC from the source of the VOC must pass through the VOC-absorbing material before being vented to the atmosphere, and wherein the VOC-absorbing material comprises: (i) a permeable substrate; and (ii) a stripper for the VOC; and (B) exposing the stripper of the VOC-absorbing material to bacteria, wherein the bacteria is selected for being capable of converting the VOC to another compound. A method for pumping a fluid from a low-pressure fluid source to a high-pressure fluid outlet and a method for storing or transporting a fluid are also provided, wherein the fluid comprises a VOC. | 2010-11-18 |
20100291660 | Method of staggered release or exposure of microorganisms for biological remediation of hydrocarbons and other organic matter - A methodology, and related systems and structures for accomplishing the methodology, of biological remediation of hazardous or undesirable organic matter, wherein a plurality of carrier members are disposed in a localized retaining member, the carrier members releasing or exposing microorganisms to the undesirable organic matter on a staggered basis over an extended period of time, the microorganisms being capable of biologically remediating the undesirable organic matter by utilizing the organic matter as a food source, thereby converting it into environmentally safe bi-products. Carrier members containing nutrients necessary for the survival of the microorganisms and having release times corresponding to the release times of the microorganisms are also provided to insure that the microorganisms remain viable upon release. | 2010-11-18 |
20100291661 | METHOD OF REMOVING HARMFUL SUBSTANCES - [Problem to be Solved] Method for removing a toxic substance to remove the toxic substances such as carbon monoxide, carbon dioxide and the particulate matter is provided without using a catalyst by the rare metal from the gas which an internal combustion engine and an incinerator exhausted. | 2010-11-18 |
20100291662 | CONTAINER FOR THE PREPARATION, PRESERVATION AND STORAGE OF BIOLOGICAL SAMPLES USING A DRYING AGENT - The invention relates to a sample container ( | 2010-11-18 |
20100291663 | CULTURE APPARATUS - The present invention relates to a culture apparatus that enables cells to be observed and dispensed without damaging the cells. An internal space of an incubator unit is provided with a dispensing area for arranging dispensers for dispensing into a culture vessel, an observation area for arranging an observation unit for observing a sample placed in the culture vessel through an observation optical system, and a transport area for arranging a transport unit for transporting the culture vessel in the horizontal and vertical directions, the dispensing area and the observation area are respectively arranged adjacent to the transport area in the horizontal direction which is a direction of transport of the transport unit, and the transport unit transports the culture vessel between the dispensing area and the observation area. The present invention can be applied to a cell culture apparatus that houses a culture vessel containing a sample in an internal space and cultures the sample under prescribed environmental conditions. | 2010-11-18 |
20100291664 | Laboratory Apparatus with Incubator - Laboratory apparatus comprises at least one cabinet; at least one incubator; at least one transfer hatch; and means for circulating air within the apparatus, wherein the at least one cabinet is connected to an incubator and a transfer hatch; wherein the at least one incubator comprises at least two discrete compartments each accessible by independent openings; and wherein the apparatus is substantially sealed against exchange of air between the cabinet and the external environment. | 2010-11-18 |
20100291665 | BIOCOMPATIBLE THREE DIMENSIONAL MATRIX FOR THE IMMOBILIZATION OF BIOLOGICAL SUBSTANCES - The present invention relates to a method of producing a solid coated carrier carrying biological material. Furthermore, the invention relates to a solid coated carrier to which biological material is attached and uses of the solid coated carrier for the preparation of a medical product. Moreover, the invention provides a method for the contacting, filtration or cleaning of blood, lymph or liquor cerebrospinalis of a patient, a method for the diagnosis of a disease and a diagnostic composition. | 2010-11-18 |
20100291666 | Molecular diagnostics system and methods - The present invention relates to automated devices and methods for the extraction of nucleic acids from cells, the amplification of segments of nucleic acid and the detection of nucleic acids, all in a convenient and portable manner. The invention is particularly suited for use in point-of-care medical diagnostic testing. | 2010-11-18 |
20100291667 | OPTICAL DETECTOR - Disclosed herein is an optical detector at least including: a first substrate in which a plurality of wells are formed; a second substrate in which a heating section is provided to heat the wells; a third substrate in which a plurality of photoirradiation sections are provided in alignment with the wells; and a fourth substrate in which a plurality of photodetection sections are provided in alignment with the wells. | 2010-11-18 |
20100291668 | Apparatus for Performing Amplicon Rescue Multiplex PCR - The present disclosure is a cassette for PCR amplification and detection of DNA amplicons, the cassette having a cassette pipette which may be moved vertically and horizontally within the cassette, at least one reagent chamber, and at least one detector, such as a microarray, for the detection of DNA amplified during the PCR amplification steps. | 2010-11-18 |
20100291669 | System for rapid identification and/or characterization of a microbial agent in a sample - An automated instrument for identification and/or characterization of a microbial agent present in a sample. The instrument includes (a) a sample removal apparatus operative to remove a test sample from a specimen container and add the test sample to a disposable separation device; (b) a separation and concentration apparatus operative on the separation device to separate the microbial agent from other components which may be present in the test sample and concentrate the microbial agent within the separation device; and (c) a identification and/or characterization module interrogating the concentrated microbial agent to identify and/or characterize the microbial agent. | 2010-11-18 |
20100291670 | Method for Detecting Candida on Skin - A method and system for rapidly detecting | 2010-11-18 |
20100291671 | Modified Viral Vector Particles - This invention relates to viral vector particles, including capsid proteins with an attachment site for the specific chemical modification of the vector particles. Furthermore, the invention relates to procedures for the production of these viral vector particles. Furthermore, the invention relates to the use of these viral vector particles as a therapeutic, prophylactic or diagnostic means in humans and primates as well as other vertebrates like cattle, pigs, birds, fish, or rodents. | 2010-11-18 |
20100291672 | REAGENT FOR INTRODUCTION OF PROTEIN OR GENE - The present invention provides a reagent for introducing a protein or gene into a cell. The reagent of the present invention is, for example, a reagent for introducing a protein or gene into a cell, which comprises a composition comprising a cationic amino acid type lipid represented by the following formula (I)-1: | 2010-11-18 |
20100291673 | ALTERNATIVE EXPORT PATHWAYS FOR VECTOR EXPRESSED RNA INTERFERENCE - The present invention is directed to nucleic acid molecules containing a loop sequence designed to circumvent exportin-5 mediated export, and methods using these novel molecules. | 2010-11-18 |
20100291674 | DISPOSABLE BIOREACTOR, KIT FOR THE SAME AND METHOD FOR ITS PRODUCTION - The present invention discloses a disposable bioreactor, consisting of a container and a cap, which is connectable to the same and cannot be detached without destruction. For this purpose, the cap comprises a retaining structure with a plurality of locking arms running in the lateral direction, while the locking arms are adapted to be resiliently shortened in the longitudinal direction and to be locked vertically to the longitudinal direction in the container by way of a retaining surface. | 2010-11-18 |
20100291675 | IgM-MEDIATED RECEPTOR CLUSTERING AND CELL MODULATION - Materials and methods for using multivalent molecules (e.g., antibodies) to modulate cellular function. A molecule can be targeted to a particular type of cell, either through direct binding to an epitope on the surface of the cell, or through a linker that recognizes both the multivalent molecule and a marker on the cell surface. | 2010-11-18 |
20100291676 | HUMANIZED ANTI-CD4 ANTIBODY WITH IMMUNOSUPPRESSIVE PROPERTIES - A humanized antibody derived from mouse monoclonal anti-CD4 antibody B-F5 is able to activate CD25+CD4+ regulatory T cells and is useful for preparing immunosuppressive compositions. | 2010-11-18 |
20100291677 | REDUCER OF IMMUNOSUPPRESSION BY TUMOR CELL AND ANTITUMOR AGENT USING THE SAME - In order to provide a gene expression enhancer for enhancing expression of FoxP3 gene in a cell; a cell differentiation inducer for inducing differentiation of a cell into a regulatory T cell; an immunosuppressor for suppressing immunity and an agent for treating hyperimmune diseases based on the abovementioned actions; an inhibitor of enhancement of gene expression for inhibiting enhancement of expression of FoxP3 gene in a cell; an inhibitor of induction of cell differentiation for inhibiting induction of differentiation of a cell into a regulatory T cell; a reducer of immunosuppression for reducing immunosuppression, a stimulator of tumor immunity and an antitumor agent based on the abovementioned actions; and the like, for example, an agent containing at least one of a cell expressing Snail protein, MCP1 protein, FSTL1 protein, membrane IL-13Ra2 protein or secretory IL-13Ra2 protein, or MCP1 protein, FSTL1 protein or secretory IL-13Ra2 protein, is used as a gene expression enhancer for FoxP3, an inducer of regulatory T cell differentiation, an immunosuppressor or an agent for treating hyperimmune diseases; and an agent containing an anti-MCP1 antibody, an anti-FSTL1 antibody or an anti-IL-13Ra2 antibody is used as an inhibitor of enhancement of FoxP3 gene expression, a reducer of immunosuppression, a stimulator of tumor immunity, an antitumor agent, or the like. | 2010-11-18 |
20100291678 | Regulatory T Cells and Their Use in Immunotherapy and Suppression of Autoimmune Responses - Based upon a strong correlation between regulator T cells (Treg cells) and suppressing or preventing a cytotoxic T cell response, provided are methods for the production of ex vivo activated and culture-expanded isolated CD4 | 2010-11-18 |
20100291679 | COMPOSITION FOR COLLECTING AND PRESERVING PLACENTAL STEM CELLS AND METHODS OF USING THE COMPOSITION - The present invention provides improved compositions and methods for the collection of stem cells from an organ, e.g., placenta. The invention provides a stem cell collection composition comprising an apoptosis inhibitor and, optionally, an enzyme such as a protease or mucolytic enzyme, vasodilator, necrosis inhibitor, oxygen-carrying perfluorocarbon, or an organ preserving compound. The invention provides methods of using the stem cell collection composition to collect stem cells and to preserve populations of stem cells. | 2010-11-18 |
20100291680 | METHODS AND COMPOSITIONS FOR INHIBITION OF MEMBRANE FUSION-ASSOCIATED EVENTS, INCLUDING HIV TRANSMISSION - The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID NO:1) peptide corresponding to amino acids 638 to 673 of the HIV-1 | 2010-11-18 |
20100291681 | Methods and compositions for selecting siRNA of improved functionality - Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed. | 2010-11-18 |
20100291682 | SYSTEM FOR TRANSPOSING HYPERACTIVE RECOMBINANT DERIVATIVES OF MOS-1 TRANSPOSON - The invention concerns a system for transposing a hyperactive recombinant derivative of Mos-1 transposon, comprising at least the two following partners: a) a Mos-1 pseudo-transposon in which an exogenous nucleotide sequence of interest replaces the nucleotide sequence encoding the original Mos-1 transposase; and b) a Mos-1 tranposase provided in trans in said pseudo-transposon, at least one of said partners being appropriately genetically modified to improve the transposition frequency of said exogenous nucleotide sequence of interest. Additionally to such systems, the invention concerns hyperactive Mos-1 transposons, hyperactive Mos-1 transposases, kits. The invention further concerns the use of one or more of abovementioned means for carrying out sequence transpositions, and more particularly efficient gene transfers. | 2010-11-18 |
20100291683 | Modified Antigen Presenting Cells and Methods of Use - The invention provides compositions comprising and methods of using antigen presenting cells into which has been introduced at least a first nucleotide sequence that encodes calnexin, wherein expression of calnexin in the antigen presenting cell increases the antigen presenting cell's ability to activate a T cell response. | 2010-11-18 |