46th week of 2018 patent applcation highlights part 29 |
Patent application number | Title | Published |
20180327815 | METHODS OF DETECTING AND TYPING PATHOGENIC STRAINS OF FRANCISELLA TULARENSIS - A method of detecting a presence of | 2018-11-15 |
20180327816 | DETECTION OF EXPOSURE TO RIP II TOXINS - The invention concerns methods for detecting exposure to a RIP II family toxin in a biological sample. The method is based on identifying the enzymatic activity of the toxin on 28sRNA and employs sensitive and specific amplification steps that allow detection in clinical samples. | 2018-11-15 |
20180327817 | Strain Typing Assay and Method Without Need for Isolation in Pure Form and Subsequent Longitudinal Strain Tracking - A system and method for strain typing without need for isolation in pure form and subsequent longitudinal strain tracking. The method includes the steps of locating one or more genetic regions present in a target. The genetic regions contain genetic loci that vary among two or more variants (i.e., strains) of the target. A device detects a unique sequence of each of the genetic loci. After a sample of biological material having the genetic loci is obtained, the device generates an amplicon for the genetic regions present in the target. The amplicons are hybridized to complimentary probes, resulting in hybridized probes and non-hybridized probes, which are detected. The detected hybridized probes are assigned an identifier. The device transforms the identifiers into a pattern. The pattern is recorded and compared to one or more other patterns recorded to determine if the pattern is different from the one or more other patterns. | 2018-11-15 |
20180327818 | METHOD FOR SELECTING A TARGET NUCLEIC ACID SEQUENCE - The present invention relates to a method for selecting a target region of interest (ROI) in a target nucleic acid molecule using a nucleic acid probe comprising a 3′ sequence capable of hybridising to a target nucleic acid molecule and acting as a primer for the production of a complement of the target ROI (i.e. by target templated extension of the primer), and a sequence capable of templating the circularisation and ligation of the extended probe comprising the reverse complement of the target ROI and a portion of the probe. The circularised molecule thus obtained contains the reverse complement of the target ROI and may be subjected to further analysis and/or amplification etc. The probe may be provided as an oligonucleotide comprising a stem-loop structure or as a partially double-stranded construct and comprises a single-stranded 3′ end region containing the target-binding site. A second binding site provided in the probe serves as the ligation template for circularisation, and the stem-loop structure, if present, is cleaved to render the second binding site available for hybridisation to the target complement. Also provided are probes and kits for carrying out such a method. | 2018-11-15 |
20180327819 | BIOSENSOR COMPRISING TANDEM REACTIONS OF STRUCTURE SWITCHING, NUCLEOLYTIC DIGESTION AND AMPLIFICATION OF A NUCLEIC ACID ASSEMBLY - The present application relates to a biosensor for detecting analytes, various kits and methods of use thereof. In particular, the biosensor's mode of operation is based on binding of analytes to a nucleic acid sequence which triggers rolling circle amplification and detection of the amplified product as the indicator of the presence of the analytes. | 2018-11-15 |
20180327820 | METHOD OF MEASURING CHIMERISM - Methods of measuring chimerism in a biological sample use informative copy number variations (CNV) in genetically distinct cell populations. Chimerism describes the co-existence of cells originating from more than one individual. Assessing CNV polymorphisms in genomic DNA provides a useful in-vitro method of measuring chimerism. The accuracy of the methods can be validated using an internal validation step. | 2018-11-15 |
20180327821 | METHOD OF DETECTING CHROMOSOME ABNORMALITY IN EMBRYO BY USING BLASTOCYST CULTURE - Provided is a method of detecting a chromosome abnormality in an embryo by using blastocyst culture. The method comprises: detecting embryonic circulating cell-free DNA in early embryonic in-vitro culture, i.e., blastocyst culture, performing uniform whole genome amplification on trace DNA, and then using a method, such as next generation sequencing, to perform analysis on the amplified DNA product, so as to determine a chromosome condition of an embryo, namely, whether aneuploidy or partial aneuploidy of chormosomes occurs. | 2018-11-15 |
20180327822 | FAST AND HIGHLY SPECIFIC DNA-BASED MULTIPLEX DETECTION - The present invention provides a method for multiplex detection of target DNA. Specifically the invention provides a solid substrate comprising a plurality of DNA probes, wherein each probe contains at least two linear nucleotide chains (LNCs). The present invention is particularly useful in multiplex reactions wherein multiple target sequences are detected in one reaction. Kits useful in the multiple target detection are also provided. | 2018-11-15 |
20180327823 | FLUIDIC CARD FOR ANALYSIS OF BIOCHIPS - A fluidic card assembly comprising a fluidic card housing ( | 2018-11-15 |
20180327824 | MICROARRAYS - Disclosed is a method of producing a two dimensional microarray using a three dimensional or structured microarray. The invention involves forming defined functionalized areas by layering an inert material over the surface structures of the three dimensional microarray. Sufficient of the inert material and of the top of the surface structures are then removed to expose defined areas of the surface structures within the inert material. | 2018-11-15 |
20180327825 | METHODS FOR DETERMINING THE ORIGIN OF DNA MOLECULES - The invention provides methods and nucleic acid molecules for determining the presence of DNA molecules from an origin of interest in a subject. | 2018-11-15 |
20180327826 | Systems and Methods for Calibration Using Dye Signal Amplification - The present teachings relate to a method of generating calibration information during a real-time polymerase chain reaction (RT-PCR) or other amplification reaction. A sample well plate or other support can contain one or more dyes or other reference materials that are subjected to the same RT-PCR thermal cycles or other conditions used to conduct amplification or other reactions on a biological sample. A set of maxima values and a set of minimum values, and/or other calibration information useful for adjusting emission data for sample dyes can be recorded, for example, for 10 cycles, 20 cycles, or each cycle of a complete RT-PCR run. Such testing of dye response under realistic operating conditions can enable more accurate characterization of plate, dye, filter, or instrument response and therefore more accurate calibration corrections and other and/or adjustments. | 2018-11-15 |
20180327827 | METHOD OF ISOLATING NUCLEIC ACID - A method of isolating DNA and RNA from a single cell sample effectively is provided. By the method of isolating, it is possible to isolate DNA and RNA from a single cell sample, and thus genome information and transcriptome information can be simultaneously collected and/or analyzed. | 2018-11-15 |
20180327828 | ION SENSOR DNA AND RNA SEQUENCING BY SYNTHESIS USING NUCLEOTIDE REVERSIBLE TERMINATORS - This disclosure is related to a method for determining the identity of a nucleotide residue of a single-stranded DNA or RNA, or sequencing DNA or RNA, in a solution using an ion-sensing field effect transistor and reversible nucleotide terminators. | 2018-11-15 |
20180327829 | Super-Resolution Sequencing - A method for template-directed sequencing-by-synthesis of an array of target polynucleotide can include:
| 2018-11-15 |
20180327830 | METHOD FOR DETERMINING CELL CLONALITY - The invention relates to a method for determining the clonality of a master cell bank (MCB) in which a transgene has been inserted. The method involves a combination of sequencing methodology and bioinformatic analysis, performed on multiple subclones originating from a common MCB, to establish a reliable set of reference transgene insertion regions in one reference subclone, and corresponding sets of comparative transgene insertion regions in one or more other subclones originating from the same MCB. Based on the degree of congruity between reference and comparative transgene insertion regions, the MCB is determined to be either monoclonal or polyclonal. | 2018-11-15 |
20180327831 | HIGHER TARGET CAPTURE EFFICIENCY USING PROBE EXTENSION - Aspects of the invention include methods for preparing an enriched sequencing library. In some embodiments, the methods involve preparing a sequencing library that is enriched for AT-rich sequences. In certain embodiments, the methods involve determining a presence or an absence of cancer, determining a cancer stage, monitoring cancer progression, and/or determining a cancer classification in a subject by analyzing an enriched sequencing library. | 2018-11-15 |
20180327832 | PROTECTIVE SURFACE COATINGS FOR FLOW CELLS - An example of a method includes providing a substrate with an exposed surface comprising a first chemical group, wherein the providing optionally comprises modifying the exposed surface of the substrate to incorporate the first chemical group; reacting the first chemical group with a first reactive group of a functionalized polymer molecule to form a functionalized polymer coating layer covalently bound to the exposed surface of the substrate; grafting a primer to the functionalized polymer coating layer by reacting the primer with a second reactive group of the functionalized polymer coating layer; and forming a water-soluble protective coating on the primer and the functionalized polymer coating layer. Examples of flow cells incorporating examples of the water-soluble protective coating are also disclosed herein. | 2018-11-15 |
20180327833 | BIOFUNCTIONALIZED NANOSHELL IMMOBILIZED MICROARRAYS AND APPLICATIONS THEREOF - Microarray platforms and methods of fabricating said microarrays without traditional high aspect ratio barriers used to define individual array elements are described herein. Self-assembled nanoshells were stabilized with a polymerized scaffold to enhance the stability in physiological conditions and serve as an optical transducer upon molecular recognition events. Soft photolithography combined with surface chemistry was developed for covalent immobilization of nanoshells onto the pre-patterned arrayed microspots for rapid multiplexed detection of membrane-binding analytes. This robust fabrication methodology is amenable for general lipid structures, and thus facilitates the integration of stable membrane architectures into diagnostic and prognostic platforms. In particular, the microarray platform may be used in diverse applications ranging from the detection of pathogens, such bacterial toxin in biological matrices, to cellular membrane studies. | 2018-11-15 |
20180327834 | METHODS AND SYSTEMS FOR GENETIC ANALYSIS - This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions. | 2018-11-15 |
20180327835 | DIGITAL COUNTING OF INDIVIDUAL MOLECULES BY STOCHASTIC ATTACHMENT OF DIVERSE LABELS - Compositions, methods and kits are disclosed for high-sensitivity single molecule digital counting by the stochastic labeling of a collection of identical molecules by attachment of a diverse set of labels. Each copy of a molecule randomly chooses from a non-depleting reservoir of diverse labels. Detection may be by a variety of methods including hybridization based or sequencing. Molecules that would otherwise be identical in information content can be labeled to create a separately detectable product that is unique or approximately unique in a collection. This stochastic transformation relaxes the problem of counting molecules from one of locating and identifying identical molecules to a series of binary digital questions detecting whether preprogrammed labels are present. The methods may be used, for example, to estimate the number of separate molecules of a given type or types within a sample. | 2018-11-15 |
20180327836 | DIGITAL COUNTING OF INDIVIDUAL MOLECULES BY STOCHASTIC ATTACHMENT OF DIVERSE LABELS - Compositions, methods and kits are disclosed for high-sensitivity single molecule digital counting by the stochastic labeling of a collection of identical molecules by attachment of a diverse set of labels. Each copy of a molecule randomly chooses from a non-depleting reservoir of diverse labels. Detection may be by a variety of methods including hybridization based or sequencing. Molecules that would otherwise be identical in information content can be labeled to create a separately detectable product that is unique or approximately unique in a collection. This stochastic transformation relaxes the problem of counting molecules from one of locating and identifying identical molecules to a series of binary digital questions detecting whether preprogrammed labels are present. The methods may be used, for example, to estimate the number of separate molecules of a given type or types within a sample. | 2018-11-15 |
20180327837 | SYSTEMS AND METHODS FOR GENETIC AND BIOLOGICAL ANALYSIS - The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices. | 2018-11-15 |
20180327838 | TRANSPOSITION OF NATIVE CHROMATIN FOR PERSONAL EPIGENOMICS - Provided herein is a method for analyzing polynucleotides such as genomic DNA. In certain embodiments, the method comprises: (a) treating chromatin isolated from a population of cells with an insertional enzyme complex to produce tagged fragments of genomic DNA; (b) sequencing a portion of the tagged fragments to produce a plurality of sequence reads; and (c) making an epigenetic map of a region of the genome of the cells by mapping information obtained from the sequence reads to the region. A kit for performing the method is also provided. | 2018-11-15 |
20180327839 | METHODS AND SYSTEMS FOR PROCESSING POLYNUCLEOTIDES - The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing. | 2018-11-15 |
20180327840 | OLIGONUCLEOTIDES FOR CONTROLLING AMPLIFICATION OF NUCLEIC ACIDS - Methods and oligonucleotides are provided for detecting an internal control nucleic acid for qualitative and/or quantitative purposes. | 2018-11-15 |
20180327841 | MARKER GENES FOR OOCYTE COMPETENCE - Cumulus cell (CC) gene expression is being explored as an additional method to morphological scoring to choose the embryo with the highest chance to pregnancy. The present invention relates to a novel method of identifying biomarker genes for evaluating the competence of a mammalian oocyte in giving rise to a viable pregnancy after fertilization, based on the use of live birth and embryonic development as endpoint criteria for the oocytes to be used in an exon level analysis of potential biomarker genes. The invention further provides CC-expressed biomarker genes thus identified, as well as prognostic models based on the biomarker genes identified using the methods of the present invention. | 2018-11-15 |
20180327842 | METHOD FOR IDENTIFYING A GREATER RISK FOR DEVELOPING BRONCHOPULMONARY DYSPLASIA - Disclosed is a method of identifying a greater risk for developing bronchopulmonary dysplasia (BPD) in a preterm infant. The method comprises obtaining a genomic DNA sample from the preterm infant's mother, identifying the nucleotide of rs2280789 SNP in the RANTES gene and the nucleotide of rs1800566 SNP in the NQO1 gene, and determining the preterm infant as being at risk of developing BPD when the genotype of rs2280789 SNP carries C nucleotide and the genotype of rs1800566 SNP carries T nucleotide. | 2018-11-15 |
20180327843 | USE OF IL-3, IL-33, AND IL-12p40 FOR CHARACTERIZATION OF THE RESPIRATORY INFECTIONS BY SYNCYTIAL RESPIRATORY VIRUS - The present invention is related to detecting respiratory diseases using molecular markers as prognostic tool of the evolution of respiratory infection cases. Concretely, during the differential diagnostic of respiratory infections caused by the Syncytial Respiratory Virus and human Metapneumovirus, it will be established the expression pattern of the severity markers of IL-3, IL-33 and IL12p40. The expression pattern of the molecular markers can be defined in biological samplers using ELISA assays, flow cytometry or PCR in real time. The confirmation of the etiological agent of the infection in combination to the pattern definition of the molecular markers IL-3, IL-33 and IL12p40 will indicate a prognostic of the disease severity. | 2018-11-15 |
20180327844 | METHODS AND PROCESSES FOR NON-INVASIVE ASSESSMENT OF GENETIC VARIATIONS - Provided herein are methods, processes, systems, machines and apparatuses for non-invasive assessment of genetic variations. | 2018-11-15 |
20180327845 | METHODS OF DIAGNOSING EPILEPSY - Various embodiments include methods of diagnosing susceptibility to epilepsy in an individual or methods of managing treatment of a neurological condition in an individual, comprising: obtaining a sample from the individual; assaying the sample to determine the presence or absence of one or more biomarkers of epilepsy; and diagnosing susceptibility to epilepsy in the individual based on the presence of one or more biomarkers of epilepsy. Various embodiments further include kits for diagnostic use, comprising a diagnostic panel of one or more of the biomarkers: Let-7d-5p, miR-340-3p, miR-484, miR-151, miR-350, miR-770-5p, miR-139-3p, miR-2985, miR-101a-5p, miR-206-3p, miR-760-3p, miR-383-5p, miR-294, and miR-328a-5p. | 2018-11-15 |
20180327846 | MARKERS FOR PRENATAL DIAGNOSIS AND MONITORING - Methods and kits are provided for diagnosing, monitoring, or predicting preeclaimpsia in a pregnant woman, trisomy 18 and trisomy 21 in a fetus, as well as for detecting pregnancy in a woman, by quantitatively measuring in the maternal blood the amount of one or more RNA species derived from a set of genetic loci and comparing the amount of the RNA species with a standard control. | 2018-11-15 |
20180327847 | Methods for the Diagnosis of Fetal Abnormalities - The present invention relates to methods for detecting, enriching, and analyzing rare cells that are present in the blood, e.g. fetal cells. The invention further features methods of analyzing rare cell(s) to determine the presence of an abnormality, disease or condition in a subject, e.g. a fetus by analyzing a cellular sample from the subject. | 2018-11-15 |
20180327848 | SYSTEM AND METHODS FOR DERIVING GENE SIGNATURE BIOMARKERS OF RESPONSE TO PD-1 ANTAGONISTS - A gene expression platform, which is a combination of a set of genes that are correlated with response to a PD-1 antagonist in multiple tumor types and a normalization gene set, is disclosed. A method and system of using the gene expression platform to derive gene signature biomarkers of anti-tumor response to a PD-1 antagonist and to test patient samples for predictive gene signature biomarkers are also disclosed. | 2018-11-15 |
20180327849 | DIAGNOSTIC AND THERAPEUTIC TARGETS IN HUMAN HER2-POSITIVE BREAST CANCER - A method of analyzing tissue in a subject having or suspected of having cancer includes obtaining an expression profile from a sample of tissue obtained from the subject, wherein the expression profile comprises the level of at least one esophageal adenocarcinoma associated lincRNA selected from the group consisting of linc-PRKD, lincRTL, lincMIA, lincNAV, and lincTMEM. | 2018-11-15 |
20180327850 | SNP ARRAYS - Provided herein is technology relating to genetic determinants of disease and particularly, but not exclusively, to methods, compositions, and systems for identifying single nucleotide polymorphisms that are functionally associated with a disease. | 2018-11-15 |
20180327851 | METHOD FOR DETERMINING SENSITIVITY TO SIMULTANEOUS INHIBITOR AGAINST PARP AND TANKYRASE - The present invention relates to a method for determining sensitivity to a simultaneous inhibitor against poly ADP ribose polymerase (PARP) and Tankyrase. According to the present invention, a colorectal treatment effect can be maximized by sorting patients having sensitivity to the simultaneous inhibitor against PARP and Tankyrase. | 2018-11-15 |
20180327852 | MOLECULAR METHODS FOR ASSESSING UROTHELIAL DISEASE - The present disclosure relates to methods of collecting exosomes and microvesicles (EMV) from urine, isolating corresponding mRNA, and analyzing expression patterns in order to diagnose and treat various urothelial cancers. In particular, various expression patterns are analyzed through a unique diagnostic formula. | 2018-11-15 |
20180327853 | PROCESS FOR THE INDENTIFICATION OF PATIENTS AT RISK FOR OSCC - The present disclosure involves a process to identify a patient likely to have OSCC by taking a sample containing miRNA from epithelial cells from the patient's oral cavity and determining the relative level of expression of miRNA sequences which have different levels of expression in epithelial cell OSCC tissue than in benign tissue. The epithelial cells are those that form the mucosal epithelium that consists mainly of keratinocytes with some immune cells. It involves determining the relative level of expression of at least miRNA sequences hsa-miR-130-3p, hsa-miR-7-5p, hsa-miR-101-3p and hsa-miR-146b-5p. It also involves discriminating between benign oral lesions and OSCC using a sample of epithelial cells of the lesion and determining the relative level of expression of miRNA sequences which have different levels of expression in epithelial cell OSCC tissue than in benign tissue. It uses the relative level of expression of at least miRNA sequences hsa-miR-196a-5p and hsa-miR-873-5p. | 2018-11-15 |
20180327854 | ASSAYS AND METHODS FOR SELECTING A TREATMENT REGIMEN FOR A SUBJECT WITH LEUKEMIA - Diagnostic methods for identifying cancer bearing subjects appropriate for treatment with CPX-351 include genetic and ex vivo testing of cells from a candidate subject. Combination treatment with CPX-351 and FLT-3 inhibitors improve CPX-351 uptake and toxicity. | 2018-11-15 |
20180327855 | METHODS OF DETECTING 5-HYDROXYMETHYLCYTOSINE AND DIAGNOSING OF CANCER - A method of detecting the level of 5-hydroxymethylcytosines (5-hmc) in a DNA molecule of a cell having a 5-hmc prevalence lower than 0.002% of total DNA bases is provided. The method comprising:
| 2018-11-15 |
20180327856 | DIAGNOSTIC MIRNAS FOR DIFFERENTIAL DIAGNOSIS OF INCIDENTAL PANCREATIC CYSTIC LESIONS - Embodiments concern methods and compositions for characterizing or evaluating neoplastic pancreatic cells using miRNAs that are measured and used in calculations to determine a risk score for a patient. | 2018-11-15 |
20180327857 | DIAGNOSTIC BIOMARKER AND DIAGNOSTIC METHOD - The present invention relates to a diagnostic biomarker, a method for identifying the diagnostic biomarker, and a diagnostic method using the diagnostic biomarker. Specifically, the present invention uses a ratio of ncRNAs as a diagnostic biomarker, identifies optimal ncRNAs pair associated with diseases based on SVM-RFE algorithm, and then uses the same for diagnosis of the diseases. | 2018-11-15 |
20180327858 | DIGITAL AMPLIFICATION - The identification of pre-defined mutations expected to be present in a minor fraction of a cell population is important for a variety of basic research and clinical applications. The exponential, analog nature of the polymerase chain reaction is transformed into a linear, digital signal suitable for this purpose. Single molecules can be isolated by dilution and individually amplified; each product is then separately analyzed for the presence of pre-defined mutations. The process provides a reliable and quantitative measure of the proportion of variant sequences within a DNA sample. | 2018-11-15 |
20180327859 | METHODS FOR DETECTING EPIGENETIC MODIFICATIONS - A method of detecting a predisposition to, or the incidence of, cancer in a sample comprises detecting an epigenetic change in at least one gene selected from an NDRG4/NDRG2 subfamily gene, GATA4, OSMR, GATA5, SFRP1, ADAM23, JPH3, SFRP2, APC, MGMT, TFPI2, BNIP3, FOXE1, SYNE1, SOX17, PHACTR3 and JAM3, wherein detection of the epigenetic change is indicative of a predisposition to, or the incidence of, cancer. Also described are pharmacogenetic methods for determining suitable treatment regimens for cancer and methods for treating cancer patients, based around selection of the patients according to the methods of the invention. The present invention is also concerned with improved methods of collecting, processing and analyzing samples, in particular body fluid samples. These methods may be useful in diagnosing, staging or otherwise characterizing various diseases. The invention also relates to methods for identifying, diagnosing, staging or otherwise characterizing cancers, in particular gastrointestinal cancers such as colorectal cancers, gastric cancers and oesophageal cancers. The methods of the invention relate, inter alia, to isolating and analyzing the human DNA component from faecal samples and blood-based samples. | 2018-11-15 |
20180327860 | METHODS AND COMPOSITIONS FOR DETECTING AND TREATING DRUG RESISTANT AKT MUTANT - Methods for identifying or diagnosing AKT inhibitor resistant cancers and methods an compositions for treating. | 2018-11-15 |
20180327861 | METHYLATION BIOMARKERS FOR PROSTATE CANCER - Different combinations of methylation status based biomarkers can be used to test for prostate cancer with high sensitivity and high specificity. | 2018-11-15 |
20180327862 | SYSTEMS AND METHODS TO DETECT RARE MUTATIONS AND COPY NUMBER VARIATION - The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease. | 2018-11-15 |
20180327863 | ARID1A AND PPP2R1A MUTATIONS IN CANCER - Two genes, ARID1A (AT-rich interactive domain-containing protein 1A) and PPP2R1A (protein-phosphatase 2, regulatory subunit 1, alpha), can be used in methods which are useful for detecting cancer, diagnosing cancer, contributing to a diagnosis of cancer, confirming a diagnosis of cancer, identifying appropriate treatments for cancer, monitoring treatment of cancer, and evaluating treatment protocols for cancer, including ovarian clear cell carcinoma, breast cancer, colon cancer, gastric cancer, lung cancer, medulloblastoma, pancreatic cancer, and prostate cancer. | 2018-11-15 |
20180327864 | C-CBL MUTATIONS AND USES THEREOF - The present invention relates generally to the fields of molecular biology and growth factor regulation. The invention concerns methods and compositions useful for diagnosing and treating human lung cancer associated with mutated c-CBL. | 2018-11-15 |
20180327865 | METHOD FOR NEXT GENERATION SEQUENCING BASED GENETIC TESTING - A next generation sequencing (NGS) based method includes applying, for one or more genetic loci, respective NGS data for genotype of a first subject, genotype of a second subject, and genotype of an alleged offspring of the first and second subjects to a statistical model calculating a value representing a likelihood the offspring is a true offspring of the first and second subjects. The NGS data includes genotype and sequencing read of the first tested subject; genotype and sequencing read of the second tested subject; and genotype and sequencing read of the alleged offspring. The statistical model utilizes a probability of the genotype of the first tested subject in a subject population; a probability of the genotype of the second tested subject in a subject population; and a probability of the genotype of the alleged offspring in a subject population. | 2018-11-15 |
20180327866 | MASSIVELY PARALLEL SINGLE CELL ANALYSIS - The disclosure provides for methods, compositions, and kits for multiplex nucleic acid analysis of single cells. The methods, compositions and systems may be used for massively parallel single cell sequencing. The methods, compositions and systems may be used to analyze thousands of cells concurrently. The thousands of cells may comprise a mixed population of cells (e.g., cells of different types or subtypes, different sizes). | 2018-11-15 |
20180327867 | MASSIVELY PARALLEL SINGLE CELL ANALYSIS - The disclosure provides for methods, compositions, and kits for multiplex nucleic acid analysis of single cells. The methods, compositions and systems may be used for massively parallel single cell sequencing. The methods, compositions and systems may be used to analyze thousands of cells concurrently. The thousands of cells may comprise a mixed population of cells (e.g., cells of different types or subtypes, different sizes). | 2018-11-15 |
20180327868 | METHOD FOR HIGH-THROUGHPUT SCREENING OF TRANSGENIC PLANTS - The invention relates to a method for quantifying levels of expression and/or quantifying copy number of a heterologous polynucleotide in a transgenic plant using quantitative or real-time polymerase chain reaction (QPCR or real-time PCR), wherein the real-time PCR is performed using a primer set specific to a heterologous terminator sequence operably linked to the heterologous polynucleotide. | 2018-11-15 |
20180327869 | A Method of Screening for Modulation of Cell Signalling Pathways - A method for the identification of new therapeutic targets and protein interaction sites for use in drug discovery. In particular the invention relates to a method for identifying inhibitors of a cell signalling pathway, the method comprising (1) providing a population of mammalian cells, each mammalian cell having an active cell signalling pathway and comprising: (a) a first heterologous nucleic acid comprising; (i) a nucleotide sequence encoding a first detectable reporter and, (ii) a constitutive regulatory element which is operably linked to the nucleotide sequence; and, (b) a second heterologous nucleic acid comprising: (i) a first nucleotide sequence encoding a repressor molecule, for example an RNA or protein, which inactivates, inhibits or suppresses expression of the first detectable reporter, (ii) a second nucleotide sequence encoding a second detectable reporter; and (iii) a signal-activated regulatory element which is activated by said cell signalling pathway, said signal-activated regulatory element being operably linked to the first and second nucleotide sequences, (2) introducing a library of test compounds into said population of mammalian cells, and; (3) determining the expression of the first and the second detectable reporters in one or more of the population of transfected cells, wherein expression of the first detectable reporter but not the second detectable reporter in a transfected cell is indicative that the test biomolecule expressed by the nucleic acid in the cell inhibits said cell signalling pathway. | 2018-11-15 |
20180327870 | PRIMERS AND PROBES FOR DETECTION AND DISCRIMINATION OF TYPES AND SUBTYPES OF INFLUENZA VIRUSES - Methods of detecting influenza, including differentiating between type and subtype are disclosed, for example to detect, type, and/or subtype an influenza infection. A sample suspected of containing a nucleic acid of an influenza virus, is screened for the presence or absence of that nucleic acid. The presence of the influenza virus nucleic acid indicates the presence of influenza virus. Determining whether the influenza virus nucleic acid is present in the sample can be accomplished by detecting hybridization between an influenza specific probe, influenza type specific probe, and/or subtype specific probe and an influenza nucleic acid. Probes and primers for the detection, typing and/or subtyping of influenza virus are also disclosed. Kits and arrays that contain the disclosed probes and/or primers also are disclosed. | 2018-11-15 |
20180327871 | TISSUE MODIFICATION DEVICES, SYSTEMS, AND METHODS - A tissue modification apparatus includes at least a first plurality of grippers aligned in a plane adapted to secure a first edge of a patch of tissue. The plurality of grippers are each secured to a first force actuator. The first plurality of grippers are each adapted to pivot relative to the first force actuator about an axis perpendicular to the plane. In some cases, a plurality of grippers are attached to a force actuator by a passive force transfer mechanism. In some cases, individual force actuators are attached by pivoted connections to individual grippers. Methods of treating tissue can secure tensioned tissue to a frame to retain the tension during a treatment (e.g., cross-linking the tissue with a chemical cross-linker). | 2018-11-15 |
20180327872 | DEVICE AND METHOD FOR PROVIDING A SELECTIVE HEAT TREATMENT ON A METAL SHEET - A device for providing selective heat treatment on a metal sheet comprising boron steel is provided. The device comprises a laser source for emitting a laser beam onto the metal sheet to provide a selective heat treatment thereon, wherein a defined heat treated grid pattern is formed on the metal sheet by the selective heat treatment. The device further comprises a control unit arranged to control the operation of the laser source for providing the defined heat treated pattern onto the metal sheet; and control the case hardness depth of the defined heat treated pattern based on a temperature parameter and a holding time parameter associated with the operation of the laser source. A method for performing controlling the case hardness depth of a selectively heat treated metal sheet of boron steel is also provided. | 2018-11-15 |
20180327873 | Engineering Steel with a Bainitic Structure, Forged Parts Produced Therefrom and Method for Producing a Forged Part - An engineering steel including (in wt.-%) up to 0.25% C, up to 0.45% Si, 0.20-2.00% Mn, up to 4.00% Cr, 0.6-3.0% Mo, 0.004-0.020% N, up to 0.40% S. 0.001-0.035% Al, 0.0005-0.0025% B, up to 0.015% Nb, up to 0.01% Ti, up to 0.10% V, up to 1.5% Ni and up to 2.0% Cu, remainder iron and unavoidable impurities, wherein the Al content % Al, the Nb content % Nb, the Ti content % Ti, the V content % V and the N content % N meet the following condition: % Al/27+% Nb/45+% Ti/48+% V/25>% N/3.75. The steel has a yield strength of at least 750 MPa, a tensile strength of at least 950 MPa and a structure having at least 80 vol.-% bainite and a total of a maximum of 20 vol.-% of retained austenite, ferrite, perlite and/or martensite. | 2018-11-15 |
20180327874 | GAS QUENCHING METHOD - A gas quenching method of the present invention includes a first stage (t | 2018-11-15 |
20180327875 | METHOD FOR MANUFACTURING A MACHINE PART - Provided is a high strength steel machine part. A method for manufacturing a machine part comprises the steps of: preparing a workpiece of steel to be a machine part; and subjecting the workpiece to a quenching process by heating a surface portion of the workpiece, with shear strain applied to the surface portion, to a heating temperature of an A3 transformation point temperature or higher, and subsequently cooling the surface portion. The workpiece has a carbon content of 0.2 mass % or more. In the step of subjecting the workpiece to a quenching process, the heating temperature is 800° C. or higher, and in the quenching process the workpiece has the surface portion cooled at a rate of 35° C./second or faster for a temperature range of 850° C. to 300° C. | 2018-11-15 |
20180327876 | CONTINUOUS-FLOW COOLING APPARATUS AND METHOD OF COOLING STRIP THEREWITH - The invention relates to a continuous flow cooling device ( | 2018-11-15 |
20180327877 | LOW-ALLOY AND CORROSION-RESISTANT STEEL FOR VEHICLE, HAVING IMPROVED CORROSION RESISTANCE UNDER CORROSIVE ENVIRONMENT, AND PREPARATION METHOD THEREOF - A low-alloy and corrosion-resistant steel for a vehicle, may include about 0.001 wt % to about 0.1 wt % of C, about 0.01 wt % to about 0.5 wt % of Si, about 0.1 wt % to about 0.6 wt % of Mn, more than 0 wt % and about 0.18 wt % or less of P, more than 0 wt % and less than about 0.02 wt % of S, about 0.001 wt % to about 0.03 wt % of Nb, more than 0 wt % and about 0.03 wt % or less of Cr, about 0.05 wt % to about 0.3 wt % of Cu, about 0.05 wt % to about 0.2 wt % of Ni, and more than 0 wt % and about 0.2 wt % or less of a combined weight of Sn and Sb, and the balance iron and inevitable impurities. | 2018-11-15 |
20180327878 | HIGH STRENGTH HOT ROLLED STEEL SHEET AND MANUFACTURING METHOD THEREOF - This high strength hot rolled steel sheet has a predetermined chemical composition, in which the structure of the high strength hot rolled steel sheet contains martensite in an area ratio of 20% or more and 60% or less and ferrite in an area ratio of 40% or more, and the total area ratio of the martensite and the ferrite is 90% or more, the average grain size of the martensite is 5.0 μm or more and 50 μm or less, the ratio of the hardness of the martensite to the hardness of the ferrite is 0.6 or more and 1.6 or less, and the tensile strength of the high strength hot rolled steel sheet is 980 MPa or more. | 2018-11-15 |
20180327879 | GRAIN-ORIENTED ELECTRICAL STEEL SHEET AND METHOD FOR MANUFACTURING SAME - The present invention relates to a grain-oriented electrical steel sheet and a method for manufacturing the same. The grain-oriented electrical steel sheet contains 2.0 wt % or more to 5.0 wt % or less of Si, 0.005 wt % or more to 0.04 wt % or less of acid-soluble Al, 0.01 wt % or more to 0.2 wt % or less of Mn, 0.01 wt % or less (excluding 0 wt %) of N, 0.01 wt % or less (excluding 0 wt %) of S, 0.01 wt % or more to 0.05 wt % or less of Sb, 0.02 wt % or more to 0.08 wt % or less of C, 0.0005 wt % or more to 0.045 wt % or less of P, 0.03 wt % or more to less than 0.08 wt % of Sn, and 0.01 wt % or more to 0.2 wt % or less of Cr, and contains balance Fe and other inevitable impurities. | 2018-11-15 |
20180327880 | METHOD OF PRODUCING STEEL MATERIAL, APPARATUS THAT COOLS STEEL MATERIAL, AND STEEL MATERIAL - A method of producing a steel material, wherein when a cooling apparatus having a plurality of cooling sections disposed side by side in a longitudinal direction of a steel material cools the steel material hot worked or cooled/reheated, the steel material is conveyed at a conveyance distance L | 2018-11-15 |
20180327881 | HIGH-STRENGTH SEAMLESS STEEL PIPE FOR OIL COUNTRY TUBULAR GOODS AND METHOD OF PRODUCING THE SAME - A seamless steel pipe having a specific chemical composition. A ratio of Ti to N is in a range of 2.0 to 5.0. The steel pipe has a microstructure including tempered martensite having a volume ratio of 95% or more, and prior austenite grains having a grain size number of 8.5 or more. In a cross-section perpendicular to a rolling direction of the steel pipe a number of nitride-based inclusions having a particle size of 4 um or more is 100 or less per 100 mm | 2018-11-15 |
20180327882 | PROCESSES FOR PRODUCING THICKER GAGE PRODUCTS OF NIOBIUM MICROALLOYED STEEL - A process for controlling austenite grain size in austenite processing through nano-scale precipitate engineering of TiN—NbC composites to produce thicker gage product of niobium microalloyed line pipe steel that includes controlling the base chemistry of the steel to include 0.003-0.004 wt. % nitrogen, 0.012-0.015 wt. % titanium, 0.03-0.07 wt. % carbon, and 0.07-0.15 wt. % niobium; conducting a first stage of roughing above the temperature of dissolution of NbC to refine austenite grain size by static recrystallization below 30 microns, cooling so that the center of the thick rolled slab is about 1040° C., conducting a second stage of roughing to promote strain induced growth of NbC on pre-existing TiN to form TiN—NbC composites to increase Zener pinning pressure on austenite grain boundaries to about 0.1 MPa in order to prevent recrystallization and grain coarsening of austenite grains beyond 30 microns at the end of roughing, and conducting finish rolling below 920° C. | 2018-11-15 |
20180327883 | METHOD FOR PRODUCING NON-ORIENTED ELECTRICAL STEEL SHEET - A method for producing a non-oriented electrical steel sheet by hot rolling a steel slab having a chemical composition including C: not more than 0.0050 mass %, Si: not more than 4.0 mass %, Mn: 0.03-3.0 mass %, P: not more than 0.1 mass %, Se: not more than 0.0010 mass %, Al: not more than 3.0 mass %, Ni: not more than 3.0 mass %, Cr: not more than 5.0 mass %, Ti: not more than 0.003 mass %, and Nb: not more than 0.003 mass % and subjecting the sheet to hot band annealing if necessary, a cold rolling, and further a finish annealing, wherein the heating in the finish annealing is conducted in two stages of performing induction heating and subsequently a radiation heating and a zone from 600° C. to 740° C. in the induction heating is heated at an average heating rate of not less than 50° C./sec, whereby a high magnetic flux density can be obtained stably. | 2018-11-15 |
20180327884 | METHOD FOR MANUFACTURING HIGH-STRENGTH GALVANIZED STEEL SHEET AND HIGH-STRENGTH GALVANIZED STEEL SHEET - A high-strength galvanized steel sheet and a method for producing the steel sheet. The steel sheet has a composition that includes C: 0.030% to 0.250%, Si: 0.01% to 3.00%, Mn: 2.00% to 10.00%, P: 0.001% to 0.100%, S: 0.0001% to 0.0200%, N: 0.0005% to 0.0100%, Ti: 0.005% to 0.200%, on a mass basis, and Fe and inevitable impurities. Additionally, the steel sheet has concentration of solute Mn at a depth of 5 μm or less from a surface of the steel sheet that is 1.50% by mass or less, and a value obtained by dividing the average mass percentage of Mn in retained austenite by the average mass percentage of Mn in ferrite is 2.0 or more. | 2018-11-15 |
20180327885 | METHODS FOR REDUCING IMPURITIES IN MAGNESIUM, PURIFIED MAGNESIUM, AND ZIRCONIUM METAL PRODUCTION METHODS - A method for reducing impurities in magnesium comprises: combining a zirconium-containing material with a molten low-impurity magnesium including no more than 1.0 weight percent of total impurities in a vessel to provide a mixture; holding the mixture in a molten state for a period of time sufficient to allow at least a portion of the zirconium-containing material to react with at least a portion of the impurities and form intermetallic compounds; and separating at least a portion of the molten magnesium in the mixture from at least a portion of the intermetallic compounds to provide a purified magnesium, wherein the purified magnesium includes an increased level of zirconium compared to the low-impurity magnesium, wherein the purified magnesium includes greater than 1000 ppm zirconium, and wherein the purified magnesium includes a reduced level of impurities other than zirconium compared to the low-impurity magnesium. A purified magnesium including at least 1000 ppm zirconium and methods for producing zirconium metal using magnesium reductant also are disclosed. | 2018-11-15 |
20180327886 | Mixer for Producing and Solidifying an Alloy in a Subterranean Reservoir - A downhole tool includes a housing configured to be placed into a subterranean environment and a mixer disposed in the housing. The mixer includes a first inlet configured to receive a fusible metal or alloy component and a second inlet configured to receive a solid metal or semi-metal component. Additionally, the mixer includes a mixing chamber configured to mix the fusible metal or alloy component and the solid metal or semi-metal component to form a liquid or partially liquid alloy. Further, the mixer includes an outlet configured to discharge the liquid or partially liquid alloy into the subterranean environment. The liquid or partially liquid alloy is configured to harden into a solid alloy over time. | 2018-11-15 |
20180327887 | REFRACTORY METAL ALLOY TARGETS FOR PHYSICAL VAPOR DEPOSITION - Refractory metal alloy targets for reducing particles in physical vapor deposition processing and refractory metal-based layer for integrated circuit applications (for example, crystallization barrier layers in non-volatile memory devices) are disclosed herein. An exemplary method for reducing particles in a PVD chamber include positioning a refractory metal alloy target in the PVD chamber, positioning a substrate in the PVD chamber a distance from the refractory metal alloy target, and sputtering material from the refractory metal alloy target to form a refractory metal-based layer over the substrate. The refractory metal alloy target includes a refractory metal (for example, tungsten or molybdenum) alloyed with a body-centered cubic (BCC) metal (for example, niobium, tantalum, vanadium, or a combination thereof). The BCC metal has a Young's modulus lower than a Young's modulus of the refractory metal. | 2018-11-15 |
20180327888 | METHODS OF FORMING SUPPORTING SUBSTRATES FOR CUTTING ELEMENTS, AND RELATED CUTTING ELEMENTS, METHODS OF FORMING CUTTING ELEMENTS, AND EARTH-BORING TOOLS - A method of forming a supporting substrate for a cutting element comprises forming a precursor composition comprising discrete WC particles, a binding agent, and discrete particles comprising Co, one or more of Al, Be, Ga, Ge, Si, and Sn, and one or more of C and W. The precursor composition is subjected to a consolidation process to form a consolidated structure including WC particles dispersed in a homogenized binder comprising Co, W, C, and one or more of Al, Be, Ga, Ge, Si, and Sn. A method of forming a cutting element, a cutting element, a related structure, and an earth-boring tool are also described. | 2018-11-15 |
20180327889 | STEEL WIRE ROD FOR WIRE DRAWING - Provided is a steel wire rod for wire drawing containing, in terms of % by mass, C: from 0.90 to 1.20%, Si: from 0.10 to 1.30%, Mn: from 0.20 to 1.00%, Cr: from 0.20 to 1.30%, Al: from 0.005 to 0.050%, and the balance being composed of Fe and impurities, wherein a content of each N, P, and S, which are contained as the impurities, is N: from 0.0070% or less, P: from 0.030% or less, S: from 0.010% or less, and the steel wire rod having a metallographic structure of which 95% or more by volume ratio is a lamellar pearlite structure, wherein the lamellar pearlite structure has an average lamellar spacing of from 50 to 75 nm, an average length of cementites in the lamellar pearlite structure is 1.0 to 4.0 μm, and a percentage of a number of cementites having a length of 0.5 μm or less among the cementites in the lamellar pearlite structure is 20% or less. | 2018-11-15 |
20180327890 | ALUMINUM ALLOY COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME - The present disclosure concerns embodiments of aluminum alloy compositions exhibiting superior microstructural stability and strength at high temperatures. The disclosed aluminum alloy compositions comprise particular combinations of components that contribute the ability of the alloys to exhibit improved microstructural stability and hot tearing resistance as compared to conventional alloys. Also disclosed herein are embodiments of methods of making and using the alloys. | 2018-11-15 |
20180327891 | Wire arc spray swivel head - Device for spray coating embraces a wire arc spray head that includes arc-making contact points and a carrier gas outlet, which is configured to swivel with feed wire in a pivoting motion. The device can be operated to spray coat a work piece. | 2018-11-15 |
20180327892 | METAL OXY-FLOURIDE FILMS FOR CHAMBER COMPONENTS - An article comprises a body having a coating. The coating comprises a Y—O—F coating or other yttrium-based oxy-fluoride coating generated either by performing a fluorination process on a yttrium-based oxide coating or an oxidation process on a yttrium-based fluorine coating. | 2018-11-15 |
20180327893 | SELF-IONIZED AND INDUCTIVELY-COUPLED PLASMA FOR SPUTTERING AND RESPUTTERING - A magnetron sputter reactor for sputtering deposition materials such as tantalum, tantalum nitride and copper, for example and its method of use, in which self-ionized plasma (SIP) sputtering and inductively coupled plasma (ICP) sputtering are promoted, either together or alternately, in the same or different chambers. Also, bottom coverage may be thinned or eliminated by ICP resputtering in one chamber and SIP in another. SIP is promoted by a small magnetron having poles of unequal magnetic strength and a high power applied to the target during sputtering. ICP is provided by one or more RF coils which inductively couple RF energy into a plasma. The combined SIP-ICP layers can act as a liner or barrier or seed or nucleation layer for hole. In addition, an RF coil may be sputtered to provide protective material during ICP resputtering. In another chamber an array of auxiliary magnets positioned along sidewalls of a magnetron sputter reactor on a side towards the wafer from the target. The magnetron preferably is a small, strong one having a stronger outer pole of a first magnetic polarity surrounding a weaker outer pole of a second magnetic polarity and rotates about the central axis of the chamber. The auxiliary magnets preferably have the first magnetic polarity to draw the unbalanced magnetic field component toward wafer. The auxiliary magnets may be either permanent magnets or electromagnets. | 2018-11-15 |
20180327894 | PHASE-CHANGE TYPE VANADIUM OXIDE MATERIAL AND PREPARATION METHOD THEREFOR - A phase-transition type vanadium oxide material and a preparation method therefor. The preparation method includes the following steps: providing a vanadium oxide base material, and implanting gaseous ions into the vanadium oxide base material, to obtain a phase-transition type vanadium oxide material having a preset phase-transition temperature. Subsequently, optionally, further annealing may be performed to adjust a bubble generation status in vanadium oxide after the gaseous ions are implanted, to further adjust the stress and strain and the phase-transition temperature. The method for preparing a phase-transition type vanadium oxide material consistent with the present invention has simple steps, desirable process reproducibility, high flexibility, and the phase-transition temperature of vanadium oxide can be continuously adjusted by changing an implantation dosage of the gaseous ions. In addition, the present invention has desirable compatibility, and can be combined with other phase-transition temperature methods, to achieve a larger phase-transition temperature adjustment range. | 2018-11-15 |
20180327895 | EVAPORATION APPARATUS - An evaporating apparatus includes a plurality of evaporation sources, and each includes a material chamber, a nozzle, and restriction plates disposed on both sides of each of the evaporation sources, wherein a distance and a height difference between the adjacent restriction plates limit a spray range of the nozzle between the adjacent restriction plates, each of the restriction plates is connected with a moving assembly, and each of the restriction plates is movable within a region between two of the adjacent evaporation sources via the moving assembly for adjusting the spray range of the nozzle. | 2018-11-15 |
20180327896 | SPUTTERING TARGET - A sputtering target includes an indium cerium zinc oxide represented by In | 2018-11-15 |
20180327897 | RE-DEPOSITION FREE SPUTTERING SYSTEM - A cylindrical target assembly for use in a physical vapor deposition (PVD) processing chamber for magnetically enhanced sputtering applications. In embodiments disclosed herein, a cylindrical target, disposed around a rotatable backing tube, has one or more contoured ends that conform to a magnetic sputtering line located outside of a uniform magnetic field. The contoured ends prevent or substantially reduce the accumulation of redeposition material at either end of the cylindrical target assembly desirably reducing particle contamination in the process chamber and on the surfaces of substrates processed therein. | 2018-11-15 |
20180327899 | METAL OXY-FLOURIDE FILMS BASED ON OXIDATION OF METAL FLOURIDES - An article comprises a body having a coating. The coating comprises a Y-O-F coating or other yttrium-based oxy-fluoride coating generated either by performing a fluorination process on a yttrium-based oxide coating or an oxidation process on a yttrium-based fluorine coating. | 2018-11-15 |
20180327900 | Volatile Dihydropyrazinly and Dihydropyrazine Metal Complexes - A composition comprising dihydropyrazinyl anions that can be coordinated as 6 electron ligands to a broad range of different metals to yield volatile metal complexes for ALD and CVD depositions are described herein. Also described herein are undeprotonated dihydropyrazines that can coordinate to metals as stabilizing neutral ligands. In one embodiment, the composition is used for the direct liquid injection delivery of the metal dihydropyrazinyl complex precursor to the chamber of an ALD or CVD chamber for the deposition of metal-containing thin films such as, for example, ruthenium or cobalt metal films. | 2018-11-15 |
20180327901 | METHOD OF CLEANING PLASMA PROCESSING APPARATUS - There is provided a cleaning method for removing a first deposit, formed on an upper electrode through an etching of a metal layer containing a metal, by using a plasma generated between a lower electrode of a lower structure and the upper electrode in a processing chamber of a plasma processing apparatus. The method includes a step of colliding ions with the first deposit formed on the upper electrode and a step of removing a second deposit, which is generated by said colliding and formed on the lower structure. Further, a cycle including the step of colliding and the step of removing is repeated multiple times. | 2018-11-15 |
20180327902 | DEVICE AND METHOD FOR VACUUM COATING - An apparatus for the vacuum treatment of substrates in a vacuum chamber includes a substrate support device with a pylon which can be rotated about a longitudinal axis and has holding means for substrates and a plasma discharge device assigned to the pylon. The plasma discharge device includes more than two plate-shaped electrodes having excitation areas, the excitation areas of which are all oriented in the direction of the pylon and a power supply device for the excitation of a plasma discharge, by at least one electrical voltage applied to at least two of the electrodes, is provided, the excited plasma acting at least on parts of the pylon and on substrates that can be arranged on them. A process performs the vacuum coating by the apparatus. | 2018-11-15 |
20180327903 | BATCH TYPE PROCESSING APPARATUS - A batch type processing apparatus for simultaneously processing a plurality of target objects to be processed, includes a main chamber; a plurality of stages, arranged in the main chamber in a height direction of the main chamber, for mounting thereon the target objects; and a plurality of covers, provided to the stages, for covering the target objects mounted on the stages. The stages and the covers surround the target objects mounted on the stages, thereby forming small processing spaces each of which has a capacity smaller than a capacity of the main chamber. | 2018-11-15 |
20180327904 | FILM FORMING APPARATUS - A film forming apparatus includes a mounting table on which a substrate is mounted; a ceiling plate facing the mounting table, the ceiling plate defining a processing space between the ceiling plate and mounting table; and a gas supply mechanism configured to supply a source gas to the processing space horizontally with respect to the substrate. A facing surface of the ceiling plate or a facing surface of the mounting table is inclined such that a gap between the facing surfaces of the mounting table and the ceiling plate becomes wider at a downstream side than at an upstream side in a flow direction of the source gas. | 2018-11-15 |
20180327905 | HIGH REGISTRATION PARTICLES-TRANSFERRING SYSTEM - Disclosed herein are implementations of a particles-transferring system, particle transferring unit, and method of transferring particles in a pattern. In one implementation, a particles-transferring system includes a first substrate including a first surface to support particles in a pattern, particle transferring unit including an outer surface to be offset from the first surface by a first gap, and second substrate including a second surface to be offset from the outer surface by a second gap. The particle transferring unit removes the particles from the first surface in response to the particles being within the first gap, secures the particles in the pattern to the outer surface, and transports the particles in the pattern. The second substrate removes the particles in the pattern from the particle transferring unit in response to the particles being within the second gap. The particles are to be secured in the pattern to the second surface. | 2018-11-15 |
20180327906 | Film Forming Apparatus, Film Forming Method, and Recording Medium - A film forming apparatus includes a rotary table having a loading area at a first surface side thereof and revolving a substrate loaded on the loading area, a rotation mechanism rotating the loading area such that the substrate rotates around its axis, a processing gas supply mechanism supplying a processing gas to a processing gas supply area so that a thin film is formed on the substrate which repeatedly passes through the processing gas supply area the revolution of the substrate, and a control part configured to perform a calculation of a rotation speed of the substrate based on a parameter including a rotation speed of the rotary table to allow an orientation of the substrate to be changed whenever the substrate is positioned in the processing gas supply area, and to output a control signal for rotating the substrate at a calculated rotation speed. | 2018-11-15 |
20180327907 | METHOD FOR PRODUCING ALUMINUIM OXIDE AND/OR NITRIDE - The present invention relates to a method for producing a layer ( | 2018-11-15 |
20180327908 | GOLD PLATING SOLUTION - Provided is a cyanide-free non-electrolytic gold plating solution including a specific nitrile compound. The plating solution is sustainable and showed good bath stability and plating performance. | 2018-11-15 |
20180327909 | pH STABLE TRIVALENT CHROMIUM COATING SOLUTIONS - A stable trivalent chromium coating solution can be prepared by heating the chromium coating solution and adjusting the pH of the chromium coating solution. The coating solution can be heated to at least 35° C. for no more than 24 hours. While the solution is hot, a basic or acidic material can be added to increase or reduce the pH to a target value, respectively. In some embodiments, the chromium coating solution can have a pH of 3.5 to 4.0 and the pH can vary no more than ±0.15 while in storage for at least 20 days. The trivalent chromium coating solution can include a fluoride compound, a zirconate compound, a corrosion inhibitor compound, a chelating agent, a phosphorous compound, and/or other compounds. | 2018-11-15 |
20180327910 | TREATMENT DEVICE FOR PICKLING AND PHOSPHATING WIRE OR WIRE PARTS, AND TREATMENT METHOD, AND TREATMENT PLANT FOR COATING THE WIRE OR THE WIRE PARTS - A treatment device is provided for treating a metal object, wherein the treatment comprises at least pickling and phosphating of the object, and, by means of the phosphating, a protective layer is produced on a surface of the object. The treatment device comprises a treatment container for holding the object to be treated and for holding a flowable treatment substance, and a pumping apparatus for circulating at least a portion of the treatment substance. The treatment substance is flowable around at least part of the object to be treated, and is a phosphorus- or phosphate-containing solution. The solution consists of water and a reaction substance, and the reaction substance consists of phosphorus or of a phosphate and at least one additional substance that improves treatment effect. The fraction of the phosphorus or the phosphate in the reaction substance is more than 98 vol % and especially preferably more than 99 vol %. | 2018-11-15 |
20180327911 | METHOD OF MANUFACTURING A STRUCTURAL ARRANGEMENT WITH A FIBER REINFORCED POLYMER COMPONENT AND A COLD GAS SPRAYED ELECTRICALLY CONDUCTIVE LAYER - A method of manufacturing a structural arrangement on the basis of a fiber reinforced polymer component, comprising at least the steps of: providing a fiber reinforced polymer component; fixing a polyether sulfone foil on the fiber reinforced polymer component, at least in a region where an electrically conductive layer is to be formed; and performing a cold gas spraying process for spraying electrically conductive particles onto the polyether sulfone foil in order to create the electrically conductive layer. | 2018-11-15 |
20180327912 | CORROSION MITIGATION FOR GEARBOX - A magnesium component of a rotary wing aircraft is provided including a groove including a first sidewall and a second sidewall arranged on opposing sides of a recessed opening. The first sidewall includes a deposit positioned adjacent the recessed opening. The deposit is formed by cold spraying one or more layers or powdered material within an area of the first sidewall from which material was removed. | 2018-11-15 |
20180327913 | ETCHING REACTANTS AND PLASMA-FREE ETCHING PROCESSES USING THE SAME - Disclosed are processes of removing layers from substrates using fluorinated reactants having the formula MF | 2018-11-15 |
20180327914 | LIQUID REMOVAL DEVICE AND LIQUID REMOVAL METHOD - [Object] To provide a liquid removal device capable of removing liquid on a steel sheet without using wringer rolls and a drier. | 2018-11-15 |
20180327915 | MULTIPURPOSE ELECTROLYTIC DEVICE (MPED) FOR FORCED OR SPONTANEOUS ELECTROLYTIC PROCESSES, WITH INDEPENDENT ELECTROLYTES - Multipurpose electrolytic device (EMPD) for forced or spontaneous electrolytic processes, which incorporates selective and unidirectional ion exchange membranes in order to separate between two or more compartments and allow electrical conductivity therebetween, with independent electrolytes for controlled electrolytic ion transformation, regardless of the chemical composition of the electrolyte containing the element of interest, with high faradaic efficiency and high energy performance. The invention also relates to a method. The device can be used for processes such as metal electrowinning (EW), metal electrorefining, electrooxidation (EOXI) and electroreduction (ERED) of ionic species. The device uses two independent, energetically suitable electrolytes, which allow controlled electrolytic ion transformation, with high faradaic efficiency and high energy performance, unlike current forced electrolysis methods, which operate with a common electrolyte. The device can be used in any aqueous medium, for example an acid environment, such as sulphuric, hydrochloric or other acid, a caustic-soda-based alkaline, or ammonium, thiocyanate or thiosulfate salts, with or without the presence of organic reactants. | 2018-11-15 |