46th week of 2018 patent applcation highlights part 24 |
Patent application number | Title | Published |
20180327313 | INORGANIC FIRE PROTECTION AND INSULATION FOAM AND USE THEREOF - A hydraulically binding composition can be used to produce an inorganic fire-protection and/or insulation foam. The composition includes: (i) a hydraulic binder, (ii) a blowing-agent mixture, (iii) a thermally expandable compound, and (iv) optionally a foam stabilizer, where the at least one thermally expandable compound, depending on a particle size thereof and an adjusted density of a foamed composition, is present in a quantity such that a foam structure of the foamed composition is not destroyed by expansion thereof during heating of the composition above an onset temperature thereof. | 2018-11-15 |
20180327314 | SINTERED ZIRCONIA MULLITE REFRACTORY COMPOSITE, METHODS FOR ITS PRODUCTION AND USE THEREOF - The present invention relates to a zirconia mullite refractory composite comprising 55 wt.-% to 65 wt.-% Al | 2018-11-15 |
20180327315 | FERRITE SHEET PRODUCTION METHOD AND FERRITE SHEET USING SAME - A ferrite sheet manufacturing method according to the present invention includes (1) stacking a plurality of molded ferrite sheets to prepare a ferrite stack having gas discharge passages between adjacent molded ferrite sheets, and (2) sintering the ferrite stack. According to the present invention, productivity can be increased, and manufacturing costs can be reduced. In addition, a gas generated during combustion of a binder can be discharged using a gas discharge passage between repeatedly uneven portions disposed in one direction, thereby preventing wrinkles or waviness generated in a peripheral portion of a ferrite sheet. Furthermore, since it is possible to improve durability and reliability of an electromagnetic wave shielding material manufactured using the ferrite sheet, the ferrite sheet can be applied to various electronic products. | 2018-11-15 |
20180327316 | BIOCERAMIC COMPOSITIONS - This invention relates to compositions and applications for a bioceramic composition that includes from about 45 to about 55% by weight of kaolinite (Al | 2018-11-15 |
20180327317 | Non-Ferroelectric High Dielectric and Preparation Method Thereof - Provided is a method for preparing a grain boundary insulation-type dielectric. The method includes the steps of obtaining a titanic acid compound and a ferroelectric having a value less than a melting point of the titanic acid compound; obtaining a mixture by adding the ferroelectric material to the titanic acid compound; and sintering the mixture at a temperature equal to or more than a melting point of the ferroelectric material. | 2018-11-15 |
20180327318 | Manufacturing Method for Ceramic Composite Material - Method for manufacturing a composite material combining a metal oxide or metalloid based matrix suited for allowing light to pass, and a mineral pigment dispersed in the matrix, the method comprising a step of mixing the mineral pigment in powder form with the matrix in powder form, and a step of sintering of the mixture under sufficient pressure such that the densification temperature of the matrix under said pressure is below the breakdown temperature of the mineral pigment, where the sintering temperature is greater than or equal to the densification temperature of the matrix and below the breakdown temperature of the mineral pigment. | 2018-11-15 |
20180327319 | Dental Zirconia Restoration Material With Uniform Transition Of Strength And Color, And Preparation Method Thereof - The application discloses a dental zirconia restoration material with uniform transition of strength and color, and a preparation method thereof. The preparation method includes the following steps: (1) pouring colored zirconia powder into a dry pressing mould in accordance with a sequence of the strength from high to low and the color from dark to light for each layer, and performing dry pressing; (2) performing isostatic cool pressing after the dry pressing; (3) performing pre-sintering after the isostatic cool pressing to obtain a greenware; and (4) performing CAD/CAM cutting on the greenware, and finally performing final sintering to obtain the dental zirconia restoration material. In the present application, the strength of a restoration can gradually increase from a cut end to the neck, the wear to adjacent teeth and jaw teeth is reduced, and long-bridge restoration can be realized due to the high strength of the neck. | 2018-11-15 |
20180327320 | Zr-BASED COMPOSITE CERAMIC MATERIAL, PREPARATION METHOD THEREOF, AND SHELL OR DECORATION - A Zr-based composite ceramic material, a preparation method thereof and a shell or a decoration are provided. The Zr-based composite ceramic material includes a zirconia matrix and a cubic Sr | 2018-11-15 |
20180327321 | Zr-BASED COMPOSITE CERAMIC MATERIAL, PREPARATION METHOD THEREOF, AND SHELL OR DECORATION - A Zr-based composite ceramic material, a preparation method thereof, and a shell or decoration are provided. The Zr-based composite ceramic material includes a zirconia matrix, a cubic Sr | 2018-11-15 |
20180327322 | COATING FORMED ON GRAPHITE SUBSTRATE AND METHOD FOR PRODUCING THE SAME - A gas impermeabe coating composed of mainly silicon carbide (SiC) without cracks, comprising of a metallic silicon powder as a silicon source, a phenolic resin as a carbon source, a silicon carbide (SiC) powder and solvent are mixed. A mixture is applied to a graphite substrate material, dried and treated in an inert gas atmosphere at temperature from 1500° C. to 2500° C., preferably around 2000° C., with the silicon carbide powder existence in the coating mixture. The metallic silicon powder and carbon constituting the phenolic resin are reacted to form silicon carbide (SiC), thereby a coating film with no cracks is obtained on the graphite substrate material, such as carbon fiber felt molded heat insulation material. | 2018-11-15 |
20180327323 | CARBON COMPOSITE COMPOSITION AND CARBON HEATER MANUFACTURED USING THE SAME - A carbon composite composition and a carbon heater are provided. The carbon composite composition may include a phenolic resin as a binder, a lubricant, and a base material that determines a specific resistance of a resistance heating element at a high temperature. The carbon composite composition may prevent a dielectric breakdown, a spark and plasma from occurring in a carbon heater, and may improve radiation efficiency of the carbon heater. | 2018-11-15 |
20180327324 | STRUCTURE OF MICROPOWDER - A method for manufacturing micropowder is provided, which includes (a) mixing a silicon precursor and a carbon precursor to form a mixture, and heating and keeping the mixture at 1600° C. to 1800° C. under a vacuum and non-oxygen condition for 120 to 180 minutes to form a silicon carbide powder; and (b) heating and keeping the silicon carbide powder at 1900° C. to 2100° C. under non-oxygen condition for 5 to 15 minutes, and then cooling and keeping the silicon carbide powder at 1800° C. to 2000° C. under the non-oxygen condition for 5 to 15 minutes to form micropowder, wherein the micropowder includes a silicon carbide core covered by a carbon film. | 2018-11-15 |
20180327325 | MICROWAVE AND INDUCTION HEAT TREATMENT OF CERAMIC COATINGS - Methods comprise loading an article comprising a ceramic coating into an induction heating system or a microwave heating system and heat treating the ceramic coating using the microwave heating system or the induction heating system within a temperature range for a duration of about 1-15 minutes. | 2018-11-15 |
20180327326 | METHODS OF MAKING POROUS CERAMIC ARTICLES - Methods for making ceramic articles, and methods for reducing extrusion pressure during processes of making ceramic articles, are disclosed. The methods include mixing a ceramic batch composition comprising amylose and amylopectin in an amylose:amylopectin ratio ranging from about 30:70 to about 95:5, and extruding the ceramic batch composition through an extrusion die to form an extruded green ceramic article. | 2018-11-15 |
20180327327 | CONTINUOUS FIBER-REINFORCED SILICON CARBIDE MEMBER, MANUFACTURING METHOD THEREOF, AND NUCLEAR REACTOR STRUCTURAL MEMBER - There are provided a continuous fiber-reinforced silicon carbide member and the like which allow sufficient improvement in a mechanical property and environmental resistance. The continuous fiber-reinforced silicon carbide member of an embodiment is a tubular shape and has a first composite material layer and a second composite material layer. In the first composite material layer, continuous fibers of silicon carbide are combined with a matrix of silicon carbide. In the second composite material layer, continuous fibers of carbon are combined with a matrix of silicon carbide. Then, the first composite material layer and the second composite material layer are stacked. | 2018-11-15 |
20180327328 | COMPOSITE FERTILISER SYSTEMS - A fertiliser pellet comprising: a first region of a nitrogen-providing fertiliser composition; and a second region adhered to the exterior of the first region, the second region comprising a fertiliser composition capable of providing (a) two or more alkali metal and/or alkaline earth metal nutrients and (b) sulphur. | 2018-11-15 |
20180327329 | BIOCHARS AND BIOCHAR TREATMENT PROCESSES - Treated biochar and methods for treating biochar are provided. The method for treating the biochar includes forcing, assisting or accelerating the movement of an infiltrant into the pores of the biochar, whereby the treatment affects properties of the biochar that provide for a more reliable and predictable biochar for use in various applications, including, but not limited to, agricultural applications. | 2018-11-15 |
20180327330 | Organic Fertilizer for Vegetables and Its Preparation Method - The present invention provides an organic fertilizer and its method of preparation. The fertilizer is an okra based organic fertilizer comprises sterilized mature okra fruits, a colloidal fluid of bacilli, 10-15 fractions of chicken droppings, 20-25 fractions of soybean residuals, 10-15 fractions of plant ashes and 45-60 fractions of water. The fertilizer can condition the soil, increase the activity of microorganisms in the soil and facilitate to increase the biomass in an individual vegetable by more than 10%; it can contain the growth of the vegetable germs and effectively control various pathogenic bacteria harmful to flowers to significantly improve the vegetable quality with the use of pesticide to less than 90%. This organic fertilizer is applicable to plantation of vegetables or fruits, cereal crops and flowers with a broad application. | 2018-11-15 |
20180327331 | REACTIVE MATERIALS FOR MANIPULATING PROPAGATION RATES AND A RESULTING CHEMICAL TIME DELAY - The present invention is directed to embodiments of reactive material (RM) and an associated chemical time delay that includes an RM, according to an embodiment of the present invention. One embodiment includes a delay material that is an RM patterned on a substrate using lithographic techniques. Another embodiment includes a delay material that is an RM deposited on a patterned substrate such as a mesh. The present invention also includes a chemical time delay that includes either embodiment of the delay material, or any variation on the delay material that would be known to or conceivable to one of skill in the art. | 2018-11-15 |
20180327332 | PROCESS FOR SELECTIVE ETHYLENE OLIGOMERIZATION WITH ANTIFOULING COMPONENTS - A process for selectively producing 1-butene comprises contacting at least one antifouling agent with at least one aluminum alkyl compound to form at least one antifouling compound in a first step. The antifouling compound may comprise a structure comprising a central aluminum molecule bound to an R1 group, bound to an R2 group, and bound to an R3 group. The process further comprises feeding the antifouling compound, an additional amount of the aluminum alkyl compound, at least one titanate compound, and ethylene into a reactor to dimerize ethylene in a second step. The titanate compound is fed as a stream separated from the streams of the antifouling compound and the additional amount of the aluminum alkyl compound. The molar ratio of the sum of the aluminum alkyl compound to the titanate compound is equal to or higher than 1.5 and equal to or lower than 3.0 | 2018-11-15 |
20180327333 | Optimizing An Alkylation Olefins Source - Alkylate is produced by supplying iso-C | 2018-11-15 |
20180327334 | OXIDATIVE COUPLING OF METHANE FOR OLEFIN PRODUCTION - The present disclosure provides natural gas and petrochemical processing systems, including oxidative coupling of methane reactor systems that may integrate process inputs and outputs to cooperatively utilize different inputs and outputs in the production of higher hydrocarbons from natural gas and other hydrocarbon feedstocks. The present disclosure also provides apparatuses and methods for heat exchange, such as an apparatus that can perform boiling and steam super-heating in separate chambers in order to reach a target outlet temperature that is relatively constant as the apparatus becomes fouled. A system of the present disclosure may include an oxidative coupling of methane (OCM) subsystem that generates a product stream comprising compounds with two or more carbon atoms, and a dual compartment heat exchanger downstream of, and fluidically coupled to, the OCM subsystem. | 2018-11-15 |
20180327335 | FCC FEED ADDITIVE FOR PROPYLENE/BUTYLENE MAXIMIZATION - An injection of a small amount of sweet vacuum residue into an FCC feed consisting of sweet gas oil combined with shape selective technology improves propylene and butylene yields significantly. | 2018-11-15 |
20180327336 | OXIDATIVE CRACKING OF ALKANES WITH FLUIDIZED VANADIUM CATALYST - Fluidizable catalysts for the gas phase oxygen-free oxidative cracking of alkanes, such as hexane, to one or more olefins, such as ethylene, propylene, and/or butylene. The catalysts comprise 1-15% by weight per total catalyst weight of one or more vanadium oxides (VO | 2018-11-15 |
20180327337 | STAGED PRESSUE FOR BUTADIENE REACTORS TO ENHANCE ENERGY RECOVERY - A process is presented for the oxidative dehydrogenation of butenes to butadienes. The process includes the use of parallel reactors, wherein the reactors are operated at different pressures. A butene feedstream is split into several portions wherein each portion is passed to a different reactor. Each reactor generates an effluent stream, and the effluent stream is cooled to generate steam for use in a lower pressure reactor. | 2018-11-15 |
20180327338 | SYSTEMS AND METHODS FOR PRODUCING PROPYLENE - According to one embodiment described in this disclosure, a process for producing propylene may comprise at least partially metathesizing a first stream comprising at least about 10 wt. % butene to form a metathesis-reaction product, at least partially cracking the metathesis-reaction product to form a cracking-reaction product comprising propylene, and at least partially separating propylene from the cracking-reaction product to form a product stream comprising at least about 80 wt. % propylene. | 2018-11-15 |
20180327339 | COMPOUNDS FOR ELECTRONIC DEVICES - The present application relates to phenanthrene compounds of a particular formula (I), their use in electronic devices, electronic devices comprising such phenanthrene compounds, as well as processes for the synthesis of such phenanthrene compounds. | 2018-11-15 |
20180327340 | PROCESS FOR DEHYDROHALOGENATION OF HALOGENATED ALKANES - A process for the manufacture of halogenated olefins in semi-batch mode by dehydrohalogenation of halogenated alkanes in the presence of an aqueous base such as KOH which simultaneously neutralizes the resulting hydrogen halide. During the process, aqueous base is continuously added to the haloalkane which results in better yields, lower by-product formation and safer/more controllable operation. | 2018-11-15 |
20180327341 | PROCESS FOR THE PREPARATION OF 2,3,3,3-TETRAFLUOROPROPENE - The present invention provides a process for preparing 2,3,3,3-tetrafluoropropene from 1,1,1,2,3-pentachloropropane and/or 1,1,2,2,3-pentachloropropane, comprising the following steps: (a) catalytic reaction of 1,1,1,2,3-pentachloropropane and/or 1,1,2,2,3-pentachloropropane with HF into a reaction mixture comprising HCl, 2-chloro-3,3,3-trifluoropropene, 2,3,3,3-tetrafluoropropene, unreacted HF, and optionally 1,1,1,2,2-pentafluoropropane; (b) separating the reaction mixture into a first stream comprising HCl and 2,3,3,3-tetrafluoropropene and a second stream comprising HF, 2-chloro-3,3,3-trifluoropropene and optionally 1,1,1,2,2-pentafluoropropane; (c) catalytic reaction of the second stream into a reaction mixture comprising 2,3,3,3-tetrafluoropropene, HCl, unreacted 2-chloro-3,3,3-trifluoropropene, unreacted HF and optionally 1,1,1,2,2-pentafluoropropane and (d) feeding the reaction mixture of step (c) directly without separation to step (a). | 2018-11-15 |
20180327342 | METHOD FOR PRODUCING DIOL - The present invention provides a method for producing a diol having a specific structure in high yields while keeping high selectivity. Provided is a method for producing a diol having a specific structure by oxidizing an olefin having a specific structure in the presence of a ruthenium compound. | 2018-11-15 |
20180327343 | COMPOSITIONS AND METHODS FOR PREPARING BETA,GAMMA-UNSATURATED ACIDS - The present disclosure provides methods for enantioselective synthesis of acyclic α-quaternary carboxylic acid derivatives via iridium-catalyzed allylic alkylation. | 2018-11-15 |
20180327344 | CRYSTAL OF MONOVALENT CATION SALT OF 3-HYDROXYISOVALERIC ACID AND PROCESS FOR PRODUCING THE CRYSTAL - The present invention provides a crystal of a monovalent cation salt of 3-hydroxyisovaleric acid (hereinafter, referred to as HMB), which is excellent in solubility and easy to handle, and a process for producing the crystal. A crystal of a monovalent cation salt of HMB is precipitated in an aqueous HMB solution containing a monovalent cation-containing compound and having a pH of 4.0 to 9.0, and the crystal of a monovalent cation salt of HMB is thereafter collected from the aqueous solution. | 2018-11-15 |
20180327345 | PRODUCTION OF ESTERS OF 3-HYDROXYPROPIONIC ACID AND ACRYLIC ACID - 3-Hydroxypropionic acid esters are obtained by reacting ethylene oxide with carbon monoxide in the presence of a cobalt catalyst, wherein poly-3-hydroxypropionate is obtained; and transesterification of the poly-3-hydroxypropionate with an alcohol in the presence of a transesterification catalyst, wherein the 3-hydroxypropionic acid ester is obtained. The transesterification catalyst is a compound of the formula ML | 2018-11-15 |
20180327346 | POLYOL ESTERS OF METATHESIZED FATTY ACIDS AND USES THEREOF - Polyol esters of metathesized fatty acids are generally disclosed herein. Methods of using such compounds, for example, as cleaning agents, solvents, and coalescents for paints and coatings, are also disclosed. | 2018-11-15 |
20180327347 | ISOMERIZATION OF MDACH - A method for isomerizing a starting mixture comprising 2,4-diamino-1-methylcyclohexane, 2,4-MDACH for short, 2,6-diamino-1-methylcyclohexane, 2,6-MDACH for short, or mixtures thereof, wherein the isomerization is carried out in the presence of a supported catalyst with zirconium dioxide as support and ruthenium as active metal. | 2018-11-15 |
20180327348 | LONG-TERM MEMORY INDUCING AGENT - [Problem] To provide a method for inducing a long-term memory in a subject need thereof. | 2018-11-15 |
20180327349 | PROCESSES FOR THE PREPARATION OF DIASTEREOMERICALLY AND ENANTIOMERICALLY ENRICHED OXAZOLINES - The invention relates to an industrially viable and advantageous process for the preparation of (2S,3R)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid, having the following formula (I) generally known as Droxidopa, or of intermediates useful in the synthesis thereof. | 2018-11-15 |
20180327350 | NEPRILYSIN INHIBITORS - In one aspect, the invention relates to compounds having the formula XII: | 2018-11-15 |
20180327351 | PRODRUGS OF CHLOROKYNURENINES - The present disclosure relates to prodrugs of 7-chlorokynurenic acid. In certain embodiments, the prodrugs include those having the structure of any one of formula (I)-(VIII), wherein R | 2018-11-15 |
20180327352 | METHOD OF REPROCESSING ALKANESULFONIC ACID - The invention relates to a method of reprocessing alkanesulfonic acid employed in a chemical process as an agent, catalyst or solvent and comprising the steps of:
| 2018-11-15 |
20180327353 | SUBSTITUTED BIARYL SULFONAMIDES AND THE USE THEREOF - Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders. | 2018-11-15 |
20180327354 | Unnatural Analogues of Calcitriol and Uses Thereof - Disclosed is a compound of Formula (I) | 2018-11-15 |
20180327355 | ISOINDOLINE DERIVATIVES - Compounds of Formula I are disclosed and methods of treating viral infections with compositions comprising such compounds. | 2018-11-15 |
20180327356 | IMPROVED PROCESS AND NOVEL POLYMORPHIC FORM OF APREMILAST - The present invention provides an improved process for the preparation of Apremilast using novel intermediates. The present invention also relates to the novel crystalline polymorphic form of Apremilast. | 2018-11-15 |
20180327357 | NOVEL ORGANIC COMPOUND, NEAR-INFRARED FLUORESCENT CONSTANT MEDIUM CONTAINING SAME, AND METHOD FOR NANO-GRANULATING CONSTANT MEDIUM - The present invention relates to a novel organic compound, a near-infrared fluorescent constant medium containing the same, and a method for nano-granulating the constant medium. | 2018-11-15 |
20180327358 | PIPERIDINONE FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS - The disclosure relates to compounds of formula I, which are formyl peptide 2 (FPR2) receptor agonists and/or formyl peptide 1 (FPR1) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for example, for the treatment of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases. | 2018-11-15 |
20180327359 | 4-((6-(2-(2,4-DIFLUOROPHENYL)-1,1-DIFLUORO-2-OXOETHYL)PYRIDIN-3-YL)OXY)BEN- ZONITRILE AND PROCESSES OF PREPARATION - Provided herein is a process for the preparation of 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-oxoethyl)pyridin-3-yl)oxy)benzonitrile. | 2018-11-15 |
20180327360 | NOVEL PYRIDINE DERIVATIVES - The invention relates to a compound of formula (I) | 2018-11-15 |
20180327361 | PHENYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS - The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: | 2018-11-15 |
20180327362 | 8-HYDROXYQUINOLINE DERIVATIVES AS DIAGNOSTIC AND THERAPEUTIC AGENTS - The present application provides compounds useful in methods of treating neurological disorders such as Alzheimer's disease, and cancer such as prostate cancer. Also provided herein are radiolabeled compounds useful for imaging techniques, and techniques for diagnosis and monitoring of treatment of neurological disorders and cancer. An exemplary radiolabeled compound provided herein is useful as a radiotracer for positron emission tomography or single-photon emission computed tomography. Methods for preparing radiolabeled compounds and methods for preparing unlabeled compounds are also provided. | 2018-11-15 |
20180327363 | DERIVATIVES OF 5-(HETERO)ARYLPYRAZOL-3-CARBOXYLIC AMIDE OR 1-(HETERO)ARYLTRIAZOL-4-CARBOXYLIC AMIDE USEFUL FOR THE TREATMENT OF INTER ALIA CYSTIC FIBROSIS - The present disclosure is based, in part, on the discovery that disclosed compounds such as those having Formula (IVa), (Va), (IV), or (V) can increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in human bronchial epithelial (hBE) cells. | 2018-11-15 |
20180327364 | MTOR INHIBITORS AND METHODS OF USE THEREOF - Disclosed are small molecule inhibitors of mammalian target of rapamycin (mTOR), and methods of using them. | 2018-11-15 |
20180327365 | HYDROXYPYRIDINONE AND HYDROXYPYRIMIDINONE BASED COMPOUNDS FOR TREATING BACTERIAL INFECTIONS - The present teachings relate to hydroxypyridinone and hydroxypyrimidinone derivatives, pharmaceutical compositions thereof, and methods of using such compounds to treat bacterial infections. | 2018-11-15 |
20180327366 | QUINOXALINE-FUSED DIBENZOSUBERANE BASED HELICENES AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME - A quinoxaline-fused dibenzosuberane based helicene is shown in formula (1), | 2018-11-15 |
20180327367 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS - Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided. | 2018-11-15 |
20180327368 | HETEROCYCLIC COMPOUNDS FOR CANCER IMAGING AND TREATMENT AND METHODS FOR THEIR USE - Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R | 2018-11-15 |
20180327369 | CFTR REGULATORS AND METHODS OF USE THEREOF - Provided herein are compounds that activate CFTR and methods for treating constipation, dry eye disorders, and other diseases and disorders. | 2018-11-15 |
20180327370 | NOVEL SPIROQUINONE DERIVATIVE COMPOUND, PRODUCTION METHOD THEREOF, AND PHARAMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING NEUROLOGICAL DISORDERS WHICH CONTAINS SAME AS ACTIVE INGREDIENT - The present invention relates to a novel spiroquinone derivative compound, a production method thereof, and a pharmaceutical composition for preventing or treating neurological disorders which contains the compound as an active ingredient | 2018-11-15 |
20180327371 | PROTEASE INHIBITORS - Compounds of the formula II: | 2018-11-15 |
20180327372 | METHODS OF CHEMICAL SYNTHESIS OF DIAMINOPHENOTHIAZINIUM COMPOUNDS INCLUDING METHYLTHIONINIUM CHLORIDE (MTC) - Methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methythioninium Chloride (MTC) (also known as Methylene Blue) are provided. | 2018-11-15 |
20180327373 | AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME - Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are methods for treating diseases associated with amyloid or amyloid like proteins. | 2018-11-15 |
20180327374 | Cyanopyridine Derivatives as Liver X Receptor Beta Agonists, Compositions, and Their Use - In its many embodiments, the present invention provides substituted cyanopyridine containing compounds of the Formula (I): and acceptable salts thereof, wherein R | 2018-11-15 |
20180327375 | AROMATIC SURFACTANTS - Disclosed are compounds of the Formula 1 wherein A is an aromatic moiety; H is a hydrophobic group comprising a main alkyl chain having from about 3 to about 26 carbon atoms and comprising a C | 2018-11-15 |
20180327376 | METHODS OF FORMING AROMATIC CONTAINING COMPOUNDS - Methods that include acylating an aromatic containing compound by reacting the aromatic containing compound with an anhydride containing compound to form an acylated aromatic containing compound. | 2018-11-15 |
20180327377 | SYNTHETIC INTERMEDIATE OF 1-(2-DEOXY-2-FLUORO-4-THIO- -D-ARABINOFURANOSYL)CYTOSINE, SYNTHETIC INTERMEDIATE OF THIONUCLEOSIDE, AND METHOD FOR PRODUCING THE SAME - A compound represented by a formula [1D] as shown below (wherein R | 2018-11-15 |
20180327378 | COMPOUND USEFUL FOR MANUFACTURING SALACINOL, METHOD FOR MANUFACTURING THE COMPOUND, METHOD FOR MANUFACTURING SALACINOL, METHODS FOR PROTECTING AND DEPROTECTING DIOL GROUP, AND PROTECTIVE AGENT FOR DIOL GROUP - An object of the present invention is to provide a novel compound useful for manufacturing salacinol, a method for manufacturing the compound, a method for manufacturing salacinol, methods for protecting and deprotecting a diol group, and a protective agent for a diol group. A compound represented by Formula (1) is a compound useful for manufacturing salacinol. | 2018-11-15 |
20180327379 | 2',6'-DIOXO-3'-DEUTERO-PIPERDIN-3-YL-ISOINDOLINE COMPOUNDS - The present application describes 2-(2′,6′-dioxo-3′-deutero-piperidin-3′-yl)isoindoles, deuterated derivatives thereof, stereoisomers thereof, pharmaceutically acceptable salt forms thereof, and methods of treating using the same. | 2018-11-15 |
20180327380 | 4-((6-(2-(2,4-DIFLUOROPHENYL)-1,1-DIFLUORO-2-HYDROXY-3-(1H-1,2,4-TRIAZOL-1- -YL)PROPYL)PYRIDIN-3-YL)OXY)BENZONITRILE AND PROCESSES OF PREPARATION - Provided herein is a process for the preparation of 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile. | 2018-11-15 |
20180327381 | ARYL CYCLOPROPYL-AMINO-ISOQUINOLINYL AMIDE COMPOUNDS - Provided herein are arylcyclopropyl amino-isoquinoline amide compounds. In particular, the disclosure provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds of the disclosure are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, cardiovascular diseases, diseases characterized by abnormal growth, such as cancers, and inflammatory diseases. The disclosure further provides compositions containing isoquinoline amide compounds. | 2018-11-15 |
20180327382 | PYRIDINYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS - The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: | 2018-11-15 |
20180327383 | PROCESS FOR THE PREPARATION OF CRYSTALLINE DEXLANSOPRAZOLE - The present invention relates to a process for the preparation of anhydrous crystalline 2-(R)-[(3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)sulfinyl]-1H-benzimidazole (dexlansoprazole). | 2018-11-15 |
20180327384 | 3-METHYL-PYRROLIDINE-2,5-DIONE DERIVATIVES USEFUL AS CGRP RECEPTOR ANTAGONISTS - The present invention provides a compound of Formula II: | 2018-11-15 |
20180327385 | AMINOPYRAZINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES - Disclosed are compounds of Formula A and Formula A-1, or a salt thereof, and pharmaceutical formulations (pharmaceutical compositions) comprising those compounds, or a salt thereof; wherein “R | 2018-11-15 |
20180327386 | CRYSTALLINE FORMS OF (R)-N-((4-METHOXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)METHYL)-2-METHYL- -1-(1-(1-(2,2,2-TRIFLUOROETHYL)PIPERIDIN-4-YL)ETHYL)-1H-INDOLE-3-CARBOXAMI- DE - The present disclosure relates to a crystalline Forms A, B, and C of (R)—N-((4-methoxy-6-methyl-2-oxo-1,2-di-hydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide, each of which are useful as modulators the activity of histone methyl modifying enzymes. The present disclosure also provides pharmaceutically acceptable compositions comprising the crystalline forms and methods of using said compositions in the treatment of various disorders. | 2018-11-15 |
20180327387 | Cyanine Compounds - Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided. | 2018-11-15 |
20180327388 | APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS AND METHODS OF USE THEREOF - The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, ester, stereoisomer, tautomer, solvate, hydrate, or combination thereof: | 2018-11-15 |
20180327389 | UREA DERIVATIVES AND USES THEREOF - The present invention provides novel compounds of any one of Formulae (I)-(III), and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of Formula (I)-(III) and pharmaceutical compositions thereof that are mucus penetrating. The invention also provides methods and kits for using the inventive compounds, and pharmaceutical compositions thereof, for treating and/or preventing diseases associated with abnormal or pathological angiogenesis and/or aberrant signaling of a growth factor (e.g., vascular endothelial growth factor (VEGF)), such as proliferative diseases (e.g., cancers, benign neoplasms, inflammatory diseases, autoimmune diseases) and ocular diseases (e.g., macular degeneration, glaucoma, diabetic retinopathy, retinoblastoma, edema, uveitis, dry eye, blepharitis, and post-surgical inflammation) in a subject in need thereof. | 2018-11-15 |
20180327390 | UREA DERIVATIVES AND USES THEREOF - The present invention provides novel compounds of any one of Formulae (I)-(III), and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of Formula (I)-(III) and pharmaceutical compositions thereof that are mucus penetrating. The invention also provides methods and kits for using the inventive compounds, and pharmaceutical compositions thereof, for treating and/or preventing diseases associated with abnormal or pathological angiogenesis and/or aberrant signaling of a growth factor (e.g., vascular endothelial growth factor (VEGF)), such as proliferative diseases (e.g., cancers, benign neoplasms, inflammatory diseases, autoimmune diseases) and ocular diseases (e.g., macular degeneration, glaucoma, diabetic retinopathy, retinoblastoma, edema, uveitis, dry eye, blepharitis, and post-surgical inflammation) in a subject in need thereof. | 2018-11-15 |
20180327391 | COMPOUND, COMPOSITIONS, AND METHODS - Compounds having activity as LRRK2 inhibitors are disclosed. The compounds are of formula (I) including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds are also disclosed. | 2018-11-15 |
20180327392 | 3-((HETERO-)ARYL)-ALKYL-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES - The invention relates to 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain. | 2018-11-15 |
20180327393 | AZIRIDINATED TRIGLYCERIDES AND POLYMERS FORMED THEREFROM - Various embodiments disclosed relate to aziridinated triglycerides and polymers formed therefrom. In various embodiments, the present invention provides an aziridinated triglyceride having the structure described herein. In various embodiments, the present invention provides a method of making the aziridinated triglyceride, a method of crosslinking the aziridinated triglyceride to form a polymer, the polymer formed from the aziridinated triglyceride, a triglyceride with at least one pendent unsaturated group that can be used to form the aziridinated triglyceride, and a method of making the triglyceride having at least one pendent unsaturated group. | 2018-11-15 |
20180327394 | BENZOFURAN DERIVATIVE, PREPARATION METHOD THEREOF AND USE THEREOF IN MEDICINE - The present invention relates to a benzofuran derivative, a preparation method thereof and a use thereof in medicine. In particular, the present invention relates to the benzofuran derivative as shown by general formula (I), the preparation method thereof, a pharmaceutical composition containing the derivative, and uses thereof as an EZH2 inhibitor and in the prevention and/or treatment of diseases such as tumours and cancers, etc., and in particular, uses thereof in the prevention and/or treatment of non-Hodgkin's lymphoma, diffuse large B-cell lymphoma, follicular lymphoma and synovial sarcoma, wherein the definitions of the substituents in the general formula (I) are the same as those defined in the description. | 2018-11-15 |
20180327395 | CRYSTALLINE FORM OF CANAGLIFLOZIN AND A METHOD OF ITS PREPARATION - The invention relates to a new crystalline form of Canagliflozin of formula I, with its systematic name (2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl) methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol5 and a method of its preparation. | 2018-11-15 |
20180327396 | NOVEL PYRIDINE DERIVATIVES - The invention relates to a compound of formula (I) | 2018-11-15 |
20180327397 | LACTAM COMPOUND DERIVATIVE AND APPLICATION THEREOF - The present invention relates to a lactam compound derivative, a medicine composition comprising the lactam compound derivative, and uses of the composition and the lactam compound derivative in preparation of a medicine for preventing or treating schizophrenia, the lactam compound derivative having a structure as shown in Formula I. | 2018-11-15 |
20180327398 | PESTICIDALLY ACTIVE AMIDE HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS - Compounds of formula I wherein the substituents are as defined in claim | 2018-11-15 |
20180327399 | HYDROXYALKYL THIADIAZOLE DERIVATIVES - Problem to be Solved There is a need for a new antibiotic having a novel mechanism of action which exhibit strong antibacterial activity not only against sensitive bacteria but also against resistant bacteria thereof, and at the same time possesses excellent solubility an a safety profile amenable to human use. | 2018-11-15 |
20180327400 | DISUBSTITUTED DIARYLOXYBENZOHETERODIAZOLE COMPOUNDS - Disubstituted diaryloxybenzoheterodiazole compound having general formula (I) or (II) wherein —Z represents a sulfur atom, an oxygen atom, a selenium atom; or an NR | 2018-11-15 |
20180327401 | IMIDAZOLIN-5-ONE DERIVATIVE USEFUL AS FASN INHIBITORS FOR THE TREATMENT OF CANCER - Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including those mediated by inhibition of fatty acid synthase (FASN) enzyme, such as, cancer, obesity or related discorders, and liver related disorders. Such compounds are represented by formula (I) as follows: | 2018-11-15 |
20180327402 | TRIAZOLOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF - Provided are triazolopyridine compounds that are inhibitors of JAK kinase, such as JAK1, compositions containing these compounds and methods for treating diseases mediated by a JAK kinase. In particular, provided are compounds of formula (I), stereoisomers, tautomers, solvates, prodrugs or pharmaceutically acceptable salts thereof, where R | 2018-11-15 |
20180327403 | HETEROCYCLIC COMPOUNDS AND USES THEREOF - Provided herein are heterocyclic compounds of Formula (I), pharmaceutical compositions containing such a compound and their therapeutic uses, methods for their preparation, intermediate compounds, pharmaceutical compositions containing such a compound, and their therapeutic uses. | 2018-11-15 |
20180327404 | ERGOLINE COMPOUNDS AND USES THEREOF - Provided herein are ergoline compounds and pharmaceutical compositions thereof. In some embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and pharmaceutical compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT | 2018-11-15 |
20180327405 | THERAPEUTIC COMPOUNDS FOR PAIN AND SYNTHESIS THEREOF - The invention provides compounds of Formula 1: | 2018-11-15 |
20180327406 | THERAPEUTIC COMPOUNDS FOR PAIN AND SYNTHESIS THEREOF - The invention provides compounds of Formula 1: | 2018-11-15 |
20180327407 | COMPOUNDS AND METHODS FOR TREATING SYNOVIAL SARCOMAS - The present invention includes compound and methods that are useful in treating certain cancers, such as synovial sarcomas. | 2018-11-15 |
20180327408 | [1,2,4]TRIAZOLO[1,5-a]PYRIMIDIN-7-YL COMPOUND - The present invention relates to a novel [1,2,4]triazolo[1,5-a]pyrimidin-yl derivative as inhibitor of phosphodiesterase 2 (PDE2). The invention is also directed to pharmaceutical compositions comprising the compound, to processes for preparing such compound and compositions, and to the use of such compound and compositions for the prevention and treatment of disorders in which PDE2 is involved, such as neurological and psychiatric disorder. | 2018-11-15 |
20180327409 | CXCR4 RECEPTOR ANTAGONISTS - The invention generally relates to compounds of formula I which are antagonists of CXCR4. The invention includes pharmaceutically acceptable salts, compositions, methods of making the compounds of formula I, and methods of using the compounds of formula I for therapeutic indications. (I) | 2018-11-15 |
20180327410 | PYRAZOLE COMPOUNDS AND METHODS OF MAKING AND USING SAME - Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain. | 2018-11-15 |
20180327411 | INDOLE AHR INHIBITORS AND USES THEREOF - The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same. | 2018-11-15 |
20180327412 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS - This application relates to compounds of Formula I: | 2018-11-15 |