45th week of 2010 patent applcation highlights part 40 |
Patent application number | Title | Published |
20100285495 | COMBINATION THERAPY FOR THE TREATMENT OF DIABETES AND CONDITIONS RELATED THERETO AND FOR THE TREATMENT OF CONDITIONS AMELIORATED BY INCREASING A BLOOD GLP-1 LEVEL - The present invention concerns combination of an amount of a GPR119 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a blood glucose level or in increasing a blood GLP-1 level in a subject over that provided by the amount of the GPR119 agonist or the amount of the DPP-IV inhibitor alone and the use of such a combination for treating or preventing diabetes and conditions related thereto or conditions ameliorated by increasing a blood GLP-1 level. The present invention also relates to the use of a G protein-coupled receptor to screen for GLP-1 secretagogues. | 2010-11-11 |
20100285496 | Methods and Devices for the Detection of Biofilm - The present invention provides methods and kits for biofilm detection. | 2010-11-11 |
20100285497 | MARKERS OF ENDOTHELIAL CELLS AND USES THEREOF - Use of a beta tubulin isotype that is differentially expressed between activated endothelial cells and quiescent endothelial cells for identifying an agent which inhibits or promotes angiogenesis and/or vascular function. | 2010-11-11 |
20100285498 | METHODS FOR DETECTING PRE-DIABETES AND DIABETES USING DIFFERENTIAL PROTEIN GLYCOSYLATION - Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid. | 2010-11-11 |
20100285499 | HUMAN p51 GENES AND GENE PRODUCTS THEREOF - Novel human genes falling within the category of family genes relating to p53 gene which is known as a cell proliferation regulatory gene, and gene products thereof. A human p51 gene characterized by containing a base sequence encoding an amino acid sequence represented by SEQ ID NO:1; a human p51 gene having a base sequence consisting of the 145- to 1488-bases in the sequence represented by SEQ ID NO:2; vectors containing these genes; host cells transformed with these vectors; a process for producing a p51 protein having the amino sequence represented by SEQ ID NO:1; which comprises culturing the above host cells and harvesting the protein from the thus obtained culture; and the p51 protein having the amino acid sequence represented by SEQ ID NO:1. | 2010-11-11 |
20100285500 | NEUROFURANS-INDICES OF OXIDANT STRESS - The invention is drawn to a new class of isoeicosanoids that have been identified as products of the oxidation of docosahexaenoic acid (DHA). The invention provides compositions and methods related to the new class of molecules. | 2010-11-11 |
20100285501 | METHODS FOR DIAGNOSING ENDOMETRIOSIS - Provided herein is a method for diagnosing and monitoring endometriosis in a subject by measuring levels of the β-subunit of fibrinogen. | 2010-11-11 |
20100285502 | NOVEL AROMATIC PRENYLTRANSFERASES, NUCLEIC ACIDS ENCODING SAME AND USES THEREFOR - In accordance with the present invention, a novel aromatic prenyltransferase, Orf2 from | 2010-11-11 |
20100285503 | FRET-BASED BINDING ASSAY - The present invention provides for an assay that identifies kinase inhibitors by employing fluorescence resonance energy transfer in a competition binding approach. | 2010-11-11 |
20100285504 | MONOCLONAL ANTIBODY WHICH BINDS MET IN FORMALIN-FIXED AND PARAFFIN-EMBEDDED TISSUES AND RELATED METHODS - In a wide variety of human solid tumors, an aggressive, metastatic phenotype and poor clinical prognosis are associated with expression of the receptor tyrosine kinase Met. Disclosed herein are (a) a monoclonal antibody named Met4, which antibody is specific for Met, and (b) a hybridoma cell line that produces Met4. The Met4 antibody is particularly useful for detecting Met in formalin-fixed tissue. Methods of using the Met4 antibody for detection, diagnosis, prognosis, and evaluating therapeutic efficacy are provided. | 2010-11-11 |
20100285505 | Device and Method for Detecting a Substance by Means of Particle Plasmon Resonance (PPR) or Particle-Mediated Fluorescence Based on Cell Surface Polarizations - The invention relates to devices and methods for detecting a substance by cell surface polarizations and the detection thereof by means of PPR or particle-mediated fluorescence. The device for detecting a substance by cell surface polarization according to the invention has cells, wherein a gene the expression of which leads to the polarized presentation of a protein on the surface of the cell is placed under the control of a promotor which can be regulated by the substance to be detected, nanoparticles which are functionalized with a molecule which can bind specifically to the surface-exposed protein, and at least one optical measurement device, such that an accumulation of the nanoparticles on the surface of the cells can be detected by particle plasmon resonance or particle-mediated fluorescence. | 2010-11-11 |
20100285506 | IMMUNODETECTION ASSAY FOR MYCOBACTERIUM TUBERCULOSIS COMPLEX - The present invention provides a method for specifically detecting a | 2010-11-11 |
20100285507 | PLASMA KALLIKREIN FRAGMENTS AS DIAGNOSTIC BIOMARKERS FOR LUNG CANCERS - Disclosed herein are diagnostic markers for lung cancer, isolated from serum glycoproteins. The disclosed diagnostic markers for lung cancer are specifically expressed only in the sera of lung cancer patients at high levels, and thus will be very useful for diagnosing lung cancer and estimating disease progression and treatment. | 2010-11-11 |
20100285508 | USE OF THE PROTEIN EM6 AS A PERFORMANCE MARKER FOR GERMINATION OF SEED LOTS AND APPLICATIONS THEREOF - The invention relates to the determination of the level, maintenance and/or performance of germination of a seed lot, by quantification of the protein EM6, belonging to the group of Late Embryogenesis Abundant (LEA) proteins. The present invention further relates to antibodies permitting the quantification of the protein EM6. | 2010-11-11 |
20100285509 | Melanoma-Associated Endogenous Retrovirus (MERV) Derived Peptide Sequences And Their Therapeutic/Diagnostic Use - The present invention provides antigenic polypeptides derived from the melanoma-associated endogenous retrovirus (MERV). These antigens are useful compounds for the detection of cancerous cells and melanoma-diagnosis as well as melanoma-prognosis. Furthermore these antigenic polypeptides of the present invention form the basis for anti-cancer vaccines. | 2010-11-11 |
20100285510 | MARKER FOR INFLAMMATORY CONDITIONS - Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described. | 2010-11-11 |
20100285511 | TRANSFORMED CELL WITH ENHANCED SENSITIVITY TO ANTIFUNGAL COMPOUND AND USE THEREOF - The present invention provides a transformed cell in which a polynucleotide having a nucleotide sequence encoding an amino acid sequence of an osmosensing histidine kinase having no transmembrane region is introduced in a functional form into a cell deficient in at least one hybrid-sensor kinase, a method of assaying the antifungal activity of a test substance using the transformed cell, and a method of searching an antifungal compound using the method, and the like. | 2010-11-11 |
20100285512 | FUNCTIONALIZED BIOCHIPS FOR SPR-MS COUPLING - The invention relates to a method for coupling in-line the analysis of molecular interactions by surface plasmon resonance (SPR) with a structural identification by mass spectrometry using the same functionalized support for both types of analysis. | 2010-11-11 |
20100285513 | Methods of Analyzing Peptide Mixtures - The present invention provides for a method of characterizing and classifying a sample of peptide or polypeptide mixtures or a biomolecule comprising a polypeptide component by using mass spectrometry and statistic methods for analyzing the mass spectrometry results. | 2010-11-11 |
20100285514 | ELECTROCHEMICAL BIOSENSOR - Networks of single-walled carbon nanotubes (SWCNTs) decorated with Au-coated Pd (Au/Pd) nanocubes are employed as electrochemical biosensors that exhibit excellent sensitivity (2.6 mA mM | 2010-11-11 |
20100285515 | FLUORESCENT PROBE - A compound represented by the following general formula (I): | 2010-11-11 |
20100285516 | CALCIUM FLUX AS A PHARMACOEFFICACY BIOMARKER FOR INHIBITORS OF HISTONE DEACETYLASE - Described herein are methods for using calcium flux as a biomarker to select and predict patients likely to respond to an apoptotic agent as therapy. Further described herein is a method of using calcium flux as a clinical biomarker to determine whether a tumor is sensitive to an HDAC inhibitor. | 2010-11-11 |
20100285517 | TRIMETHYLAMINE COMPOUNDS AS RISK PREDICTORS OF CARDIOVASCULAR DISEASE - Methods of characterizing a test subject's risk of having or developing cardiovascular disease are provided. The methods include using an analytic device to determine levels of choline-related trimethylamine-containing compounds such as trimethylamine N-oxide, choline, or betaine in a biological sample obtained from the subject and comparing the levels of the choline-related trimethylamine-containing compound in the subject's biological sample to a control value. The test subject's risk of having cardiovascular disease is then characterized as higher if the levels of the choline-related trimethylamine-containing compound are higher than the control value. Also provided are methods of identifying a subject at risk of experiencing a complication of atherosclerotic cardiovascular disease, and methods of evaluating the efficacy of a cardiovascular therapeutic agent in a subject with cardiovascular disease using levels of choline-related trimethylamine-containing compounds. | 2010-11-11 |
20100285518 | PHOTOACOUSTIC DETECTION OF ANALYTES IN SOLID TISSUE AND DETECTION SYSTEM - A preferred system for detecting an analyte in solid tissue, such as an intact lymph node, in vitro includes a laser arranged to generate a pulsed laser beam into solid tissue, which can be a fully intact lymph node. An acoustic sensor, and preferably at least three acoustic sensors are arranged in different positions to span a three dimensional space, such as in an X, Y and Z coordinate system, to detect photoacoustic signals generated within the lymph node. At least one computer receives signals from the acoustic sensor(s). The computer determines the presence or absence of, and preferably the position of analyte, from the signals and the timing of the signals. A preferred method for detecting an analyte in a lymph node in vitro includes exposing an extracted lymph node to a pulsed laser beam. A photoacoustic signal is sensed. The photoacoustic signal is analyzed to confirm the presence or absence of an analyte in the lymph node. Preferably, multiple photoacoustic signals are sensed from sensors that span a three dimensional space and the position of analyte is also determined. | 2010-11-11 |
20100285519 | QUINOLINONE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS - The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds of Formula (I). The invention also provides pharmaceutical compositions comprising such compounds, the use such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds. Wherein; R | 2010-11-11 |
20100285520 | SAMPLE PREPARATION FOR ENVIRONMENTAL SAMPLING - A system and method for preparing samples to test an environmental surface for an analyte of interest. The system can include a deformable self-supporting receptacle comprising a reservoir, and a loaded substrate positioned in the reservoir of the deformable self-supporting receptacle. The loaded substrate can include a substrate and a source collected from the surface. The method can include combining the loaded substrate and a diluent in the reservoir, and agitating the loaded substrate and the diluent to form a liquid composition comprising the source and the diluent. | 2010-11-11 |
20100285521 | ADIPOSE TISSUE COLLECTION AND PRE-PROCESSING DEVICES FOR USE IN LIPOSUCTION PROCEDURE - Devices and methods are described for pre-processing tissue samples containing cells of interest for various therapeutic procedures. Fibrous material may be extracted from the tissue sample through a shredding and separating device, resulting in a non-fibrous sample containing the cells of interest, which may then be washed and centrifuged to remove fluids, oil, and contaminants. The sample may then be digested in a large-volume container, and a piston within the container may push the resulting liberated cell suspension through a cell concentrator such as a hollow-fiber separation module. | 2010-11-11 |
20100285522 | Versatile Multichannel Capillary Biosensor System - The multichannel capillary biosensor system includes a selecting valve system for selection of the sample or a reagent. The selecting valve system is connected to a second valve system accommodating a sensing channel and a first bypass channel. The second valve system is connected to a directing valve system having at least two positions, with a first position being connected to a second bypass channel and a second position being connected to a detector for detecting the analyte. The device has a pump connected at one end to the second bypass channel and the detector and at a second end to a waste vessel. The device also has a control system for controlling the device. The analyte can be selected from the group of microorganisms, macromolecules, and small molecules. | 2010-11-11 |
20100285523 | SYSTEM AND METHOD FOR ANALYZING FLUIDS - A spectrometric sensor for measuring a spectra value of a flowing fluid. The spectrometric sensor comprises a light source for emitting a first light flux toward a sample of the flowing fluid, a light detector for measuring a first intensity of a reflection of the first light flux from the flowing fluid and a second intensity of a second light flux received via the flowing fluid, and a control unit configured for generating at least one spectra value according to at least one of the first and second intensities. | 2010-11-11 |
20100285524 | NOVEL MICROORGANISM AND METHOD FOR PRODUCING CAROTENOID USING THE SAME - [Object] To provide a canthaxanthin selective producing bacterium being able to easily extract and purify canthaxanthin, which is one of carotenoids, and a method for producing canthaxanthin by a culture method. | 2010-11-11 |
20100285525 | METHOD - A method of producing one or more of a carbohydrate ester, a protein ester, a protein subunit ester or a hydroxyl acid ester, which method comprises admixing an acyl donor, an acyl acceptor and water to produce a high water environment comprising 5-98% water, wherein said acyl donor is a lipid substrate selected from one or more of the group consisting of a phospholipid, a lysophospholipid, a triacylglyceride, a diglyceride, a glycolipid or a lysoglycolipid and said acyl acceptor is selected from one ore more of the group consisting of a carbohydrate, a protein, a protein subunit, or a hydroxyl acid; and contacting the admixture with a lipid acyltransferase, such that said lipid acyl transferase catalyses one or both of the following reactions: alcoholysis or transesterification. | 2010-11-11 |
20100285526 | Compositions and Methods for Fusion Protein Separation - The present invention relates to compositions and methods for fusion protein separation utilizing a peptide linker comprising a novel thrombin cleavage site. | 2010-11-11 |
20100285527 | Novel Polypeptide, cDNA Encoding the Same, and Use Thereof - Novel polypeptides produced by a human adult brain tissue, a cell line derived therefrom, a cell line derived from human bone marrow and a human umbilical cord venous endothelial cell line; a process for producing these polypeptides; cDNAs encoding the polypeptides; fragments hybridizable selectively with the cDNA sequences; replication or expression plasmids having the cDNAs integrated thereinto; host cells transformed by the plasmids; antibodies against the above polypeptides; and medicinal compositions containing the peptides or the antibodies. | 2010-11-11 |
20100285528 | METHOD, VECTOR AND SYSTEM FOR EXPRESSING POLYPEPTIDES - Disclosed herein are methods and systems for expressing a polypeptide in a | 2010-11-11 |
20100285529 | FELINE GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR PROTEINS - The present invention relates to canine interleukin-4, canine or feline Flt-3 ligand, canine or feline CD40, canine or feline CD154, canine interleukin-5, canine interleukin-13, feline interferon alpha, and/or feline GM-CSF proteins; to canine interleukin-4, canine or feline Flt-3 ligand, canine or feline CD40, canine or feline CD 154, canine interleukin-5, canine interleukin-13, feline interferon alpha, and/or feline GM-CSF nucleic acid molecules, including those that encode canine interleukin-4, canine or feline Flt-3 ligand, canine or feline CD40, canine or feline CD 154, canine interleukin-5, canine interleukin-13, feline interferon alpha, and/or feline GM-CSF proteins, respectively; to antibodies raised against such proteins; and to inhibitory compounds that regulate such proteins. The present invention also includes methods to identify and obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to regulate an immune response in an animal. | 2010-11-11 |
20100285530 | E.Coli Host Cells with Modified Phos/Psts Periplasmic Phosphate-binding Proteins, and Method of Manufacturing Recombinant Fabs - The present invention provides an | 2010-11-11 |
20100285531 | Therapeutic and Diagnostic Methods and Compositions Targeting 4Ig-B7-H3 and its Counterpart NK Cell Receptor - The present invention relates to the identification of 4Ig-B7-H3 protein as a tumor associated molecule that imparts protection from NK cell-mediated lysis via a 4Ig-B7-H3 receptor on NK cells. The invention provides compounds that interfere with interactions between the 4Ig-B7-H3 protein and its receptor that can be used to potentiate NK cell cytotoxicity. Also provided are compounds that bind 4Ig-B7-H3-expressing cells so as to inhibit or eliminate them. The compounds are particularly useful in the treatment of tumors, inflammatory conditions, infections and transplantation. Also provided are methods for diagnosing disease by detecting a 4Ig-B7-H3 protein. | 2010-11-11 |
20100285532 | PRODUCTION OF HETEROLOGOUS PROTEINS OR PEPTIDES - A method of producing a flagellin-based chimeric protein includes culturing a | 2010-11-11 |
20100285533 | CULTURE MEDIA ADDITIVE AND PROCESS FOR USING IT - The present invention relates to an improved cell culture additive with a content of polyamines and iron, media containing it and processes for using it for an improved cell growth, cell viability or cellular productivity. | 2010-11-11 |
20100285534 | COMBINED THERMOCHEMICAL PRETREATMENT AND REFINING OF LIGNOCELLULOSIC BIOMASS - One aspect of the present invention relates to a method of processing lignocellulosic material, comprising initial steam pretreatment to give pretreated lignocellulosic material with an average particle size, followed by refining to give refined lignocellulosic material with an average particle size, wherein the average particle of the pretreated lignocellulosic material is greater than the average particle size of the refined lignocellulosic material. In certain embodiments, the lignocellulosic material is selected from the group consisting of grass, switch grass, cord grass, rye grass, reed canary grass, miscanthus, sugar-processing residues, sugar cane bagasse, agricultural wastes, rice straw, rice hulls, barley straw, corn cobs, cereal straw, wheat straw, canola straw, oat straw, oat hulls, corn fiber, stover, soybean stover, corn stover, forestry wastes, recycled wood pulp fiber, sawdust, hardwood, and softwood. | 2010-11-11 |
20100285535 | PCR HOT START BY MAGNESIUM SEQUESTRATION - The present invention is directed to a synthetic peptide having a length of not more than 30 amino acids comprising a divalent cation binding site. Such a peptide according to the present invention is part of a composition for nucleic acid amplification and provides for a so-called hot start effect. | 2010-11-11 |
20100285536 | METHOD AND APPARATUS FOR AMPLIFICATION OF NUCLEIC ACID SEQUENCES BY USING THERMAL CONVECTION - The present invention provides a nucleic acid sequence amplification method and apparatuses thereof that are simple in the design and easy to miniaturize and integrate into complex apparatuses, with capability of using DNA polymerases that are not thermostable. In the present invention, a plurality of heat sources are combined to supply or remove heat from specific regions of the sample such that a specific spatial temperature distribution is maintained inside the sample by locating a relatively high temperature region lower in height than a relatively low temperature region. | 2010-11-11 |
20100285537 | SELECTIVE TAGGING OF SHORT NUCLEIC ACID FRAGMENTS AND SELECTIVE PROTECTION OF TARGET SEQUENCES FROM DEGRADATION - Methods are provided for selective tagging of short nucleic acids comprising a short target nucleotide sequence over longer nucleic acids comprising the same target nucleotide sequence. The methods can involve performing one or two cycles of amplification of a sample comprising long nucleic acids and short nucleic acids, each comprising the same target nucleotide sequence with at least two target-specific primers or primer pairs under suitable annealing conditions, wherein the primer pairs comprise: an inner primer or primer pair that can amplify the target nucleotide sequence on long and short nucleic acids (wherein each inner primer comprises a 5′ nucleotide tag; and an outer primer or primer pair that amplifies the target nucleotide sequence on long nucleic acids, but not on short nucleic acids); whereby the amplification after a second cycle produces at least one tagged target nucleotide sequence that comprises two nucleotide tags, one from each inner primer, with the target nucleotide sequence located between the nucleotide tags. | 2010-11-11 |
20100285538 | METHODS FOR NUCLEIC ACID MANIPULATION - A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The recombination intermediate is treated with a high fidelity polymerase to permit the replication and amplification of the target nucleic acid sequence. In preferred embodiments, the polymerase comprises a polymerase holoenzyme. In further preferred embodiments, the recombination factor is bacteriophage T4 UvsX protein or homologs from other species, and the polymerase holoenzyme comprises a polymerase enzyme, a clamp protein and a clamp loader protein, derived from viral, bacteriophage, prokaryotic, archaebacterial, or eukaryotic systems. | 2010-11-11 |
20100285539 | Process for Manufacturing Tagatose Using Soy Oligosaccharide - The present invention relates to a method for producing tagatose using soy oligosaccharide or soluble sugar solution containing the same, more precisely, a method for producing tagatose comprising the following steps; hydrolyzing soy oligosaccharide by using α-galactosidase selectively; producing tagatose continuously by enzymatic isomerization of galactose obtained from the hydrolysate; separating the produced tagatose by chromatography; and recycling the non-reacted materials. | 2010-11-11 |
20100285540 | Process for the preparation of (R)-Beta-Arylalanines by coupled Racemase/Aminomutase catalysis - A process for producing (R)-β-arylalanines is described. The process converts (S)-α-arylalanine to (R)-β-arylalanine using phenylalanine aminomutase and amino acid racemase. The (R)-β-arylalanine product can be used to form pharmaceutically useful drugs. Also disclosed are DNA sequences encloding phenylalanine aminomutase and amino acid racemase enzymes, sequences for PCR primers of the DNA sequences, and sequences for expressed aminomutase and amino acid racemase enzymes. | 2010-11-11 |
20100285541 | TRANSAMINASE BIOCATALYSTS - The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides. | 2010-11-11 |
20100285542 | CATALYZED PREPARATION OF (METH)ACRYLATES OF N-HYDROXYALKYLATED AMIDES - The claimed invention relates to a process for preparing (meth)acrylates of N-hydroxyalkylated amides, in which open-chain N-hydroxyalkylated amides are esterified with (meth)acrylic acid or transesterified with at least one (meth)acrylic ester in the presence of at least one heterogeneous catalyst selected from the group consisting of an inorganic salt and an enzyme. | 2010-11-11 |
20100285543 | Novel Endophytic Fungi And Methods Of Use - This invention provides a novel endophytic fungus, | 2010-11-11 |
20100285544 | Novel aminotransferase, gene encoding the same, and method of using them - The invention relates to a novel aminotransferase, DNA encoding the enzyme, a recombinant vector into which the DNA has been introduced, and a transformant into which the vector has been introduced. Further, the invention also relates to a method for producing an optically active amino compound utilizing the enzyme or transformant. The aminotransferase of the invention has an ability of efficiently converting a ketone compound, particularly a cyclic ketone compound to an optically active amino compound. According to the invention, a method for efficiently producing an optically active amino compound, particularly an optically active cyclic amino compound is provided. | 2010-11-11 |
20100285545 | BIOSYNTHETIC ROUTES TO LONG-CHAIN ALPHA,OMEGA-HYDROXYACIDS, DIACIDS AND THEIR CONVERSION TO OLIGOMERS AND POLYMERS - A substantially pure | 2010-11-11 |
20100285546 | Genetically Modified Microorganisms for Producing Itaconic Acid with High Yields - Genetically modified microorganisms that produce itaconic acid at high yields and uses thereof. | 2010-11-11 |
20100285547 | NEW MICRO-ORGANISMS FOR THE PRODUCTION OF 1,2-PROPANEDIOL OBTAINED BY A COMBINATION OF EVOLUTION AND RATIONAL DESIGN - The present invention concerns a new method combining evolution and rational design for the preparation of a strain of micro-organism for the production of 1,2-propanediol from a carbon source. | 2010-11-11 |
20100285548 | Process And Apparatus For The Microbial Production Of A Specific Product And Methane - The process according to the invention for the microbial production of a specific product and methane comprises the following steps: a) the production in a bioreactor ( | 2010-11-11 |
20100285549 | RECOMBINANT MICROORGANISM HAVING BUTANOL PRODUCTION CAPACITY AND BUTANOL PRODUCTION METHOD - This invention relates to a recombinant microorganism having improved butanol production capacity and butanol production with the use of such recombinant microorganism with good efficiency. In this invention, the acetoacetyl-CoA synthase gene encoding an enzyme capable of synthesizing acetoacetyl-CoA from malonyl-CoA and acetyl-CoA and a group of genes involved in butanol biosynthesis that enables synthesis of butanol from acetoacetyl-CoA are introduced into a host microorganism. | 2010-11-11 |
20100285550 | Delignification of Lignocellulose-Containing Material - The invention relates to processes of delignifying lignocellulose-containing material, wherein the lignocellulose-containing material is treated with a delignification catalyst and a lignin solubilizing agent. | 2010-11-11 |
20100285551 | METHOD OF STIMULATING ETHANOL PRODUCTION AND GROWTH OF AQUATIC PLANTS - A method of stimulating ethanol production and growth of aquatic plants includes the steps of placing aquatic plants in a cell containing water and creating an oxygenated condition within the cell to initiate an aerobic process. The aquatic plants create and store carbohydrates during the aerobic process. The cell is then covered with a light blocking cover during the anoxic condition to inhibit light from entering the cell. An anoxic condition is created within the cell to initiate an anaerobic process by the aquatic plants. The aquatic plants increase in size and release ethanol into the water by metabolism of stored carbohydrates during the anaerobic process. The ethanol is then sequestered from the water. | 2010-11-11 |
20100285552 | Methods for Fermentation of Xylose and Hexose Sugars - Methods and systems for the isomerization and/or fermentation of xylose and hexose sugars are disclosed. | 2010-11-11 |
20100285553 | PROCESS FOR PRETREATING A LIGNOCELLULOSIC MATERIAL WITH A VIEW TO PRODUCING BIOETHANOL, AND BIOETHANOL PRODUCTION PROCESS - A process for pretreating a lignocellulosic plant raw material in order to obtain a pretreated material that is capable of being hydrolyzed and fermented for the production of bioethanol, includes the following successive steps:
| 2010-11-11 |
20100285554 | METHOD OF STIMULATING ETHANOL PRODUCTION AND GROWTH OF AQUATIC PLANTS - A method of stimulating ethanol production and growth of aquatic plants includes the steps of placing aquatic plants in a cell containing water and creating an anoxic condition within the pool to initiate an anaerobic process by the aquatic plants. The aquatic plants increase in size and release ethanol by metabolism of stored carbohydrates during the anaerobic process. An oxygenated condition is then created within the cell to initiate an aerobic process. The aquatic plants create and store carbohydrates during the aerobic process. The steps of creating anoxic and oxygenated conditions are repeated to stimulate increased aquatic plant size and to increase the release of ethanol. | 2010-11-11 |
20100285555 | DISTRIBUTED BIOFUEL MANUFACTURING SYSTEM (DBMS) - The Distributed Biofuel Manufacturing System (DBMS) integrates three critical innovations which may advance the state of the art for biofuels manufacturing to a distributed production and local distribution model. This model yields a sustainable and commercially viable means of production for biofuels. Essential to this new model is a Portable Biorefinery (PBR) which allows for onsite conversion of biomass into biofuels, an accompanying set of advanced biocatalysts, and finally a multi-role harvesting and pre-processing technology to optimize both deliberate and “threat” biomass for biofuels. Utilizing either high yield deliberate biomass “plantations” or salvaging available threat biomass, the portable biorefinery will process high volumes of variable biomass into dense liquid energy format and other energy products which can then be utilized locally. This disclosure seeks to avoid the logistical overhead and economic limitations of traditional centralized industrial fuels manufacturing. | 2010-11-11 |
20100285556 | BIOGAS PLANT AND PROCESS FOR THE PRODUCTION OF BIOGAS FROM LIGNEOUS RENEWABLE RESOURCES - The present invention relates to a biogas plant and to a process for the production of biogas from ligneous renewable resources, in particular straw. Means are provided for pre-treating the ligneous renewable resource in order to bring about chemical, thermal and/or mechanical digestion of said resource before it is introduced into a fermenter in which anaerobic bacterial fermentation takes place. | 2010-11-11 |
20100285557 | Efficient Astaxanthin Production Strains Derived from Haematococcus Pluvialis - The present invention pertains to a method for the efficient production of carotenoids. In particular, the present invention is directed to a method for producing carotenoid and carotenoid-containing cells, especially astaxanthin and astaxanthin-containing cells, by generating mutant microorganisms belonging to the photoautotrophic algae of the Class Chlorophyceae and culturing same. The present invention further relates to methods of generating microorganisms producing high yields of carotenoids, in particular astaxanthin, products containing said microorganisms or said carotenoids, and the use of said carotenoids produced by the microorganisms according to the present invention and deposited mutant strains generated from said microorganisms. | 2010-11-11 |
20100285558 | Apparatus and Method for High-Throughput Micro-Cell Culture with Mechanical Stimulation - A method for high-throughput micro-cell culture with mechanical stimulation includes providing cells on a membrane, supplying a culture medium to the cells, and vibrating the membrane by exerting and varying a fluid pressure on the membrane such that the cells are mechanically stimulated through the membrane. | 2010-11-11 |
20100285559 | RADIATION-RESISTANT MUTANTS OF A HALOPHILIC ARCHAEON AND USES THEREOF - The present invention relates to variants of the model halophile | 2010-11-11 |
20100285560 | RETICULOCYTE MIMETICS AND METHOD OF PREPARATION OF THE SAME - In one aspect of the present disclosure there is provided a method for preparing reticulocyte mimetics. In another aspect of the present disclosure there are provided reticulocyte mimetics obtained using the method. In yet another aspect of the present disclosure there is provided a whole blood reference control including the reticulocyte mimetics as provided. In still another aspect of the present disclosure there is provided a composition useful for preparing reticulocyte mimetics. | 2010-11-11 |
20100285561 | IMMOBILISATION OF BIOLOGICAL MOLECULES - A method of immobilising a biological molecule on a substrate comprises: (i) covalently attaching a substantially three-dimensional polysilane polymer to a substrate; and (ii) attaching a biological molecule onto and/or within the polymer. The method may additionally comprise the steps of coating the substrate (or the chemically protective layer) with a layer of radiation sensitive material, exposing the substrate to a source of radiation, and incubating the substrate in the presence of a first species of biological molecule. | 2010-11-11 |
20100285562 | ISOCYCLOMALTOOLIGOSACCHARIDE(S), ISOCYCLOMALTOOLIGOSACCHARIDE-FORMING ENZYME, THEIR PREPARATION AND USES - A non-reducing saccharide by providing a novel non-reducing saccharide composed of glucose as constituents, a novel enzyme forming the non-reducing saccharide, a method and process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a composition comprising the non-reducing saccharide, and uses thereof are provided by use of an isocyclomaltooligosaccharide(s) having a structure represented by Formula 1, | 2010-11-11 |
20100285563 | Non-Ribosomal Peptide Synthetases - Novel tailor-made artificial non-ribosomal peptide synthetases (NRPSs) for non-ribosomal synthesis and/or modification of peptides of a predetermined length and composition and/or for modification of individual amino acids are described. The fusion of building units of said peptide synthetases in particular linker regions makes it possible to specifically prepare by means of “modular molecule construction kits” NRPSs which are capable of synthesizing peptides of a desired structure. | 2010-11-11 |
20100285564 | Anticalins - The invention relates to the production of novel proteins exhibiting bonding activity for certain ligands, the so-called anticalins. To this end, the structure of peptides of the lipocalin family is modified by amino acid replacement in their natural ligand binding pocket using generic engineering methods. Alike immunoglobulin, the anticalin thus obtained can be used to identify or bond molecular structures. | 2010-11-11 |
20100285565 | ESCHERICHIA COLI EXPRESSING THE CYTOCHROME P-450 GENE AND A METHOD FOR MICROBIAL CONVERSION USING THEM - Disclosed is a means for improving the poor conversion efficiency in a bioconversion system using an | 2010-11-11 |
20100285566 | GLUCOSE DEHYDROGENASE AND METHOD FOR PRODUCING THE DEHYDROGENASE - A novel glucose dehydrogenase, which is an enzyme that has high substrate specificity, can be produced at a low cost, is not affected by oxygen dissolved in a measurement sample and, in particular, has superior, thermal stability is obtained by culturing a microorganism belonging to the genus | 2010-11-11 |
20100285567 | TAT SIGNAL PEPTIDES FOR PRODUCING PROTEINS IN PROKARYOTES - This invention provides polynucleotides encoding TAT fusion proteins, and methods for producing proteins of interest in a host cell. In particular, the present invention relates to polynucleotides, vectors, polypeptides and methods for expressing organophosphate-degrading enzymes e.g. organophosphorus hydrolase (OPH) in host cell, such as a | 2010-11-11 |
20100285568 | RECOMBINANT FACTOR X WITH NO GLYCOSYLATION AND METHOD FOR PREPARING THE SAME - A Factor X (hereinafter referred to as “FX”) with a high activity is provided. The present invention relates to a method for efficiently preparing a recombinant, two-chain FX which comprises intervening glycosylation at such an amino acid sequence that is essential for glycosylation in FX to thereby allow for expression of a recombinant FX with no glycosylation, and the recombinant FX with no glycosylation obtained by said method. | 2010-11-11 |
20100285569 | Pectate lyases with increased thermostability and/or enzymatic activity - Using site-directed mutagenesis to mutate the | 2010-11-11 |
20100285570 | FLUORIDE PROCESSING METHOD - The invention relates to methods for processing [ | 2010-11-11 |
20100285571 | SYSTEMS AND METHODS FOR AUTO-CALIBRATION OF RESISTIVE TEMPERATURE SENSORS - The invention relates to systems and methods for calibrating and using resistance temperature detectors. In one embodiment, the system includes a calibration circuit comprising a resistance temperature detector in a bridge circuit with at least one potentiometer, and a programmable gain amplifier coupled to the bridge circuit. Embodiments of the invention further comprise methods for calibrating the bridge circuit and the programmable gain amplifier for use with the resistance temperature detector and methods for determining the self heating voltage of the bridge circuit. | 2010-11-11 |
20100285572 | Inhibition Assay Method and Device for Detection of Antibiotics - An aspect of the disclosure is a method and device for the detection of antibiotics in a sample. Embodiments include a microbial culture with growth indicators and sensitivity adjustment reagents. Adjustment reagents include a variety of antibiotic binders that can be added to microbial culture to reduce sensitivity to certain antibiotics. Some embodiments include multiple buffers with a variety of pKa ranges. Some embodiments also include a complete self-contained apparatus for sampling and testing. | 2010-11-11 |
20100285573 | Apparatus for processing a sample in a liquid droplet and method of using the same - The invention provides an apparatus and a method of processing a biological and/or chemical sample in a liquid droplet. The apparatus comprises a processing compartment, which is defined by a reservoir and an immobilisation member. The processing compartment is further adapted to accommodate a medium, which is immiscible with the liquid droplet, and of a lower surface energy than the liquid of the liquid droplet. The reservoir is defined by a circumferential wall and a base. The immobilisation member is arranged within the reservoir and comprises a surface that is patterned in such a way that it comprises at least one predefined immobilisation area. The predefined immobilisation area within the patterned surface is of a higher surface energy than the medium. Furthermore the at least one predefined area is of a higher surface energy than the remaining surface and of a sufficient width in the plane of the surface to allow, in said hydrophobic medium, the immobilisation of the liquid droplet on the hydrophilic area via hydrophilic-hydrophilic or hydrophobic-hydrophobic interactions. The remaining surface is of at most about the same surface energy as the medium. In the method of the invention the medium is disposed into the apparatus, such that the predefined immobilisation area is entirely covered by the medium. The liquid droplet is disposed onto the predefined immobilisation area, whereby the liquid droplet is immobilised thereon via hydrophilic-hydrophilic or hydrophobic-hydrophobic interactions. A process is performed on the biological and/or chemical sample in said liquid droplet. | 2010-11-11 |
20100285574 | BIOMASS HYDROTHERMAL DECOMPOSITION APPARATUS AND METHOD - A biomass hydrothermal decomposition apparatus includes, a biomass feeder ( | 2010-11-11 |
20100285575 | BIOREACTOR - The invention relates to a bioreactor which comprises a closed housing with a housing wall and at least one chamber which is connected to the housing wall. The at least one chamber comprises a chamber inlet and outlet for respectively supplying and discharging material to and from the at least one chamber. The housing comprises a housing inlet for supplying material to the chamber inlet and a housing outlet for discharging treated material from the chamber outlet to the outside of the bioreactor. The bioreactor forms a closed volume in which a reactor pressure prevails in the bioreactor which is higher than the external pressure outside the bioreactor, in such a way that the bioreactor is self-supporting. | 2010-11-11 |
20100285576 | Method to produce synthesis gas or liquid fuels from commingled algae and coal feedstock using a steam-hydrogasification reactor and a steam methane reformer with CO2 utilization through an algae farm - This invention involves the conversion of coal-algae or resid-algae commingled slurry feedstock into a high methane content product gas using a steam hydrogasification process. This gas is then reformed into synthesis gas (H | 2010-11-11 |
20100285577 | Isolation, Characterization and Propagation of Germline Stem Cells - Methods are provided for the isolation, characterization and propogation of germline cells stem cells from fetal and adult mammals. Additionally, isolated populations of germline cells having different phenotypes are disclosed wherein the subpopulations are capable of forming long-term cultures of multipotent or pluripotent cells or are capable of differentiating into mature germline cells and repopulating a sterile reproductive organ. The multipotent or pluripotent germline cells are also suitable for differentiation into tissue-specific somatic cells for therapeutic purposes. | 2010-11-11 |
20100285578 | Nucleic Acid Purification - The inventive self-contained apparatus for isolating nucleic acid, cell lysates and cell suspensions from unprocessed samples apparatus, to be used with an instrument, comprises at least one input, and: (i) a macrofluidic component, comprising a chamber for receiving said unprocessed sample from a collection device and at least one filled liquid purification reagent storage reservoir; and (ii) a microfluidic component in communication with said macrofluidic component via at least one microfluidic element, said microfluidic component further comprising at least one nucleic acid purification matrix; and (iii) a drive mechanism on said instrument for driving said liquid purification reagent, through said microfluidic element and said nucleic acid purification matrix, wherein the only inputs to said apparatus are via said chamber and said drive mechanism. | 2010-11-11 |
20100285579 | PREANTRAL FOLLICLE DERIVED EMBRYONIC STEM CELLS - The present invention relates to a method for producing a preantral follicle-derived embryonic stem cell and a preantral follicle-derived embryonic stem cell. The present method comprises the steps of (a) obtaining a preantral follicle from mammalian ovaries; (b) growing the preantral follicle in vitro; (c) maturing an oocyte in vitro present in the cultured preantral follicle; (d) activating the matured oocyte for parthenogenesis; (e) culturing the activated oocyte to form a blastocyst; and (f) culturing inner cell mass (ICM) cells of the blastocyst to produce the preantral follicle-derived embryonic stem cell. | 2010-11-11 |
20100285580 | Cardiac Conduction System (CCS) Progenitor Cells and Uses Thereof - The present invention provides isolated stem cells and progenitor cells, including HCN4-expressing CCS progenitor cells, HCN4- and Islet 1-expressing sinoatrial node cells or progenitor cells thereof, and Islet 1-expressing cardiovascular stem cells that do not express HCN4. The invention further provides differentiated cell types derived from the CCS progenitor cells and cardiovascular stem cells of the invention. In addition, the invention provides methods of differentiating the cells of the invention, methods for screening for agents that affect the differentiation of the cells of the invention, methods for evaluating the potential toxicity of drugs using the cells of the invention, cell therapy using the cells of the invention, and methods of treating heart arrhythmia by ablating HCN4-expressing cells. | 2010-11-11 |
20100285581 | Solid Phase Cell Isolation and/or Enrichment Method - The present invention concerns a solid phase method for isolating and/or enriching predetermined cells from a sample. Such methods are used e.g. to isolate and enrich predetermined cells like fetal cells from a sample of maternal peripheral blood, tumor cells from a sample of body fluid or stem cells from a fluid or fluidized sample of body tissue or body fluid. The solid phase isolation method of the present invention is used for isolating predetermined cells from a sample containing such predetermined cells by binding the predetermined cells to a solid surface. According to the invention the sample is contacted with the solid surface and then removed from the solid surface, wherein the sample or a washing buffer contains a polyol during or after contacting the sample with the solid surface. | 2010-11-11 |
20100285582 | VARIOUS HUMAN DENTAL STEM CELLS HAVING A MINERALIZATION ABILITY AND THE METHOD FOR CULTURING THEM - The present invention relates to various human dental stem cells having a mineralization ability and a method for culturing the same, more precisely postnatal stem cells having a mineralization ability, which are separated from human dental tissues such as dental pulp (DPSCs), periodontal ligament (PDLSCs), periapical follicle (PAFSCs) and mandibular bone marrow (MBMSCs) and a method for culturing the same under the optimum growth conditions. The human dental stem cells of the present invention can be obtained without additional injury as well as new stem cell sources such as teeth extracted from orthodontic purposes, prophylactically extracted nondecayed third molar teeth and discarded bone segments from orthognathic surgery, so that they can be effectively used for regeneration of injured teeth. | 2010-11-11 |
20100285583 | COMPOUNDS AND METHODS FOR INHIBITING PLATELET AGGREGATION - The present invention relates to compounds and methods for inhibiting platelet aggregation. In an embodiment, the compound of the present invention contains the sulfatide binding region of the N-terminal phosphotyrosine binding domain (N-PTB) of Disabled-2 (Dab2). | 2010-11-11 |
20100285584 | ENGINEERED CELLULAR PATHWAYS FOR PROGRAMMED AUTOREGULATION OF DIFFERENTIATION - The present invention provides compositions and methods for programming mammalian cells to perform desired functions. In particular, the present invention provides compositions and methods for programming stem cells to differentiate into a desired cell type. A quorum sensing systems that regulates the expression of cell fate regulators is introduced into mammalian host cells, such as stem cells. The quorum sensing systems generally comprises vectors that express the components of a bacterial quorum sensing pathway, including proteins which catalyze the synthesis of an autoinducer and a gene encoding a regulatory partner of the autoinducer, and vectors in which genes encoding cell fate regulators are operably linked to a promoter induced by the autoinducer/regulatory partner complex. The system can also comprise vectors in which genes encoding additional cell fate regulators are operably linked to a promoter that is induced by a factor synthesized in response to a first stage of differentiation, so that a second stage of differentiation is triggered. | 2010-11-11 |
20100285585 | METHOD FOR EXTRACELLULAR MATRIX MEDIATED DIFFERENTIATION AND PROLIFERATION OF STEM CELLS - There is provided a method of culturing a stem cell on extracellular matrix extracted from support cells and in a stem cell culture medium comprising medium conditioned by the support cells | 2010-11-11 |
20100285586 | METHOD OF PRODUCING A POPULATION OF CELLS - A method is provided for producing an in vitro or ex vivo method of producing a population of lineage committed haematopoietic progenitor, or mature haematopoietic cells, other than cells of the neutrophil lineage, which method comprises the steps of: (a) providing a population of cells comprising haematopoietic progenitor cells; and (b) culturing the population of cells in an animal cell culture medium comprising one or more cytokines that differentiate said progenitor cells into lineage committed haematopoietic progenitor and/or mature haematopoietic cells, under conditions of low oxidative stress, the culture medium being agitated when the cells are at a cell density at which oxygen transfer via the surface of the culture medium is insufficient for growth of the progenitor cells and the progeny thereof under static conditions, to produce a population of lineage committed haematopoietic progenitor, or mature haematopoietic cells, other than cells of the neutrophil lineage. The resulting population of cells can be used to increase the number of haematopoietic cells in a patient. | 2010-11-11 |
20100285587 | Tissue Graft - A method of preparing a tissue graft material is disclosed. The disclosure also relates to a multipurpose tissue graft material and to methods of using same as a replacement for vascular and non-vascular tissue. | 2010-11-11 |
20100285588 | Apparatus and Methods for Cell Isolation - A unitary apparatus for isolating cells from adipose tissue including a lipid separation processor with a dispersing head equipped with a plurality of ports and a digestion chamber for dissociation of the constituent cells disposed in adipose tissue. The lipid separating apparatus is useful for the separation of lipids and adipocytes from a mixed cell population. A cell seeding chamber may be attached to the cell isolation apparatus. The components of the apparatus may be packaged in modular kit form. | 2010-11-11 |
20100285589 | GENERATION OF PLURIPOTENT CELLS FROM FIBROBLASTS - Provided are methods and compositions useful for producing and propagating stem cells from fibroblasts. | 2010-11-11 |
20100285590 | Homologous Recombination in Multipotent Adult Progenitor Cells - The invention relates to methods of altering gene expression by homologous recombination in a multipotent adult progenitor cell (MAPC). In particular, methods of producing a recombinant MAPC, of correcting a genetic defect in a mammal, of providing a functional and/or therapeutic protein to a mammal, and of transforming a MAPC are provided. MAPCs containing an erogenous DNA as well as recombinant MAPCs and their differentiated progeny are also provided. | 2010-11-11 |
20100285591 | CYCLIN D POLYNUCLEOTIDES, POLYPEPTIDES AND USES THEREOF - The invention provides isolated polynucleotides, specifically Cyclin D polynucleotides, and their encoded proteins that are involved in cell cycle regulation. The invention further provides recombinant expression cassettes, host cells, transgenic plants, and antibody compositions. The present invention provides methods and compositions relating to altering cell cycle protein content and/or composition of plants for the purpose of increasing transformation efficiency. | 2010-11-11 |
20100285592 | SINGLE EXPRESSION VECTOR FOR GENERATION OF A VIRUS WITH A SEGMENTED GENOME - The present invention encompasses an expression vector that is capable of generating a virus from a segmented genome. In particular, a single expression vector may be utilized to produce influenza virus in cultured cells. The expression vector can be delivered in a purified DNA form or by a suitably designed bacterial carrier to cells in culture or to animals. This invention increases the virus generation efficiency, which benefits vaccine development. The bacterial carrier harboring such a plasmid encoding an attenuated virus may be used as a vaccine against corresponding viral disease. | 2010-11-11 |
20100285593 | INTERNAL STANDARDS AND METHODS FOR USE IN QUANTITATIVELY MEASURING ANALYTES IN A SAMPLE - The invention provides methods for quantitatively analyzing a plurality of analytes in a sample. Also described are general and specific internal standards useful in such analysis. In particular embodiments, these standards are described as useful in liquid chromatography/mass spectroscopy systems, which are also described herein. Moreover, in certain embodiments, the quantification methods of the present invention are useful in increasing the precision and/or accuracy of multiple analyte quantification for analytes contained in a single sample mixture using known analyte derivatives simultaneously analyzed, and compared to the unknown analytes. | 2010-11-11 |
20100285594 | MICROBEAD KIT AND METHOD FOR QUANTITATIVE CALIBRATION AND PERFORMANCE MONITORING OF A FLUORESCENCE INSTRUMENT - Fluorescently labeled microsphere calibration and quality control particles for use in establishing standardized fluorescence detector setup, monitoring daily QC of flow cytometers and quantitative calibration of the fluorescence detectors in traceable units of measure (molecules equivalent soluble fluorescence; MESF). | 2010-11-11 |