45th week of 2010 patent applcation highlights part 39 |
Patent application number | Title | Published |
20100285395 | FUEL CELL - In a fuel cell having a cell structure in which a gas flow passage is formed by an expanded metal, a bond portion connecting a mesh of the expanded metal stands partially upright in a position where a bond length is shortened so as to form a part of a strand portion. Hence, in an opening formed by the mesh of the expanded metal, a surface area on which front and rear openings overlap in a direction increases when seen from an direction. Thus, a sectional area of gas flow passages constituted by a continuum in the direction of the openings overlapping in the direction increases. As a result, a gas flow flows without making repeated narrow turns, leading to a reduction in gas pressure loss. | 2010-11-11 |
20100285396 | NON-NOBLE METAL INEXPENSIVE CONDUCTIVE COATINGS FOR FUEL CELL BIPOLAR PLATES - One embodiment of the invention includes a process including providing an electrically conductive fuel cell component having a first face, and depositing a graphitic/conductive carbon film on the first face of the electrically conductive fuel cell component comprising sputtering a graphite target using a closed field unbalanced magnetron field. | 2010-11-11 |
20100285397 | Hybrid catalyst, method of fabricating the same, and fuel cell comprising the same - A hybrid catalyst is disclosed, which has a structure of Pt/oxygen-donor/carbon-nanotube. The hybrid catalyst has a superior electrochemical characteristic and high carbon monoxide conversion efficiency even in a low reacting temperature, and thus is useful at detoxification of carbon monoxide. Besides, the oxygen-donor utilized in the present invention is cheap and is commercially reachable, therefore the hybrid catalyst of the present invention is advantageous in commercial usage. Also, a method of fabricating the above hybrid catalyst and a fuel cell comprising the above hybrid catalyst are disclosed. | 2010-11-11 |
20100285398 | TAMPER INDICATING ARTICLE - Tamper indicating articles that include a surface-feature image-generating layer and an adhesive layer are described. The surface-feature image-generating layer generates a visible, surface-feature-generated image upon exposure to light. The intensity of the surface-feature-generated image is reduced when taped-over. Single-image and dual-image tamper indicating articles are also described, including buried dual-image and adjacent dual-image tamper indicating articles. | 2010-11-11 |
20100285399 | WAFER EDGE EXPOSURE UNIT - A wafer edge exposure unit comprises a chuck for supporting a wafer. The chuck is rotatable about a central axis. A plurality of light sources are positioned or movably positionable with a common radial distance from the axis of the rotatable chuck, each light source configured to direct exposure light on a respective edge portion of the wafer simultaneously. | 2010-11-11 |
20100285400 | POSITION DETECTING APPARATUS, POSITION DETECTING METHOD, EXPOSURE APPARATUS AND DEVICE MANUFACTURING METHOD - A position detecting apparatus includes a light source which supplies a detecting light; a light-collecting optical system which collects the detecting light onto a diffracted light generating portion provided on the object; a light guiding optical system which guides, to a predetermined position, a diffracted measuring light generated from the diffracted light generating portion by receiving the detecting light and a reference light generated from a reference surface by receiving the detecting light; and a photodetector which is arranged at the predetermined position and which detects interference fringes generated by the diffracted measuring light and the reference light. Three-dimensional positional information of, for example, a mask pattern surface or an exposure surface of a photosensitive substrate can be highly accurately detected by a relatively simple construction. | 2010-11-11 |
20100285401 | CURABLE TONER COMPOSITIONS AND PROCESSES - Processes for producing emulsion aggregation toners are provided. In embodiments, methods of the present disclosure may be utilized to produce toners suitable for low melt applications, including use in flexible packaging applications, where low pile height is desired for low cost and flexibility. In embodiments, the EA toners may be prepared by optimizing the particle size of the emulsion, the choice of and amount of aggregating agent utilized, and the solids content of the emulsion. | 2010-11-11 |
20100285402 | TONER AND METHOD OF MANUFACTURING TONER - A toner is provided which includes a first binder resin, a second binder resin that is a reaction product of a compound having an active hydrogen group with a polymer reactive with the active hydrogen group, a colorant, and a release agent. The toner includes the second binder resin in an amount of from 6.4 to 40.9% by weight, and the reaction product includes organic-solvent-insoluble components in an amount of from 20 to 95% by weight. A method of manufacturing the toner is also provided. | 2010-11-11 |
20100285403 | CURABLE TONER COMPOSITIONS AND PROCESSES - Processes for producing emulsion aggregation toners are provided. In embodiments, methods of the present disclosure may be utilized to produce toners suitable for low melt applications, including use in flexible packaging applications, where low pile height is desired for low cost and flexibility. In embodiments, the EA toners may be prepared by optimizing the particle size of the emulsion, the choice of and amount of aggregating agent utilized, and the solids content of the emulsion. | 2010-11-11 |
20100285404 | METHOD FOR PRODUCING POLYAMIDE AND RESIN COMPOSITION - Disclosed is a method for producing polyamide, wherein a diimidazolide compound represented by the general formula (1) shown below is reacted with a diamine compound represented by the general formula (2) shown below. The present invention provides a method for producing a chlorine-free high molecular weight alkali-soluble polyamide by simple process. | 2010-11-11 |
20100285405 | RADIATION-SENSITIVE RESIN COMPOSITION - A radiation-sensitive resin composition includes a resin, a radiation-sensitive acid generator, an acid diffusion controller, and a mixed solvent. The radiation-sensitive acid generator includes a compound (I) shown by a following general formula (I). The mixed solvent includes about 50 mass % to about 90 mass % of propylene glycol monomethyl ether acetate, | 2010-11-11 |
20100285406 | ABLATABLE ELEMENTS FOR MAKING FLEXOGRAPHIC PRINTING PLATES - Flexographic printing plates and other relief images can be formed from a laser-ablatable element having a laser-ablatable layer that is from about 300 to about 4,000 μm in thickness. The laser-ablatable layer includes a film-forming material that is a laser-laser-ablatable material or the film-forming material has dispersed therein a laser-ablatable material. The laser-ablatable material is a polymeric material that when heated to 300° C. at a rate of 10° C./minute, loses at least 60% of its mass to form at least one predominant low molecular weight product. The laser-ablatable material also comprises at least 0.01 weight % of a depolymerization catalyst that is a Lewis acid or organometallic based catalyst. The element can be imaged by ablation at an energy of at least 1 J/cm | 2010-11-11 |
20100285407 | Composition for forming a silicon-containing antireflection film, substrate having the silicon-containing antireflection film from the composition and patterning process using the same - There is disclosed a thermosetting silicon-containing antireflection film-forming composition, to form a silicon-containing antireflection film in a multilayer resist process used in a lithography, wherein the composition is at least capable of forming—on an organic film that is an underlayer film having a naphthalene skeleton—a silicon-containing antireflection film whose refractive index “n” and extinction coefficient “k” at 193 nm satisfy the following relationship: 2n−3.08≦k≦20n−29.4 and 0.01≦k≦0.5. There can be provided, in a multilayer resist process used in a lithography, a thermosetting silicon-containing antireflection film-forming composition to form a silicon-containing antireflection film which can form an excellent pattern having depressed reflection of an exposing light at the time when a photoresist film is formed on the silicon-containing antireflection film formed on an organic film having a naphthalene skeleton as a resist underlayer film and subsequently a resist pattern is formed; has excellent dry etching properties between the photoresist film—which is the upperlayer of the silicon-containing antireflection film—and the organic film—which is the underlayer—; and has an excellent storage stability, and a substrate having the silicon-containing antireflection film from the composition for forming the silicon-containing antireflection film, and a patterning process using the same. | 2010-11-11 |
20100285408 | PHOTOSENSITIVE RESIN COMPOSITION, PHOTOSENSITIVE ELEMENT, METHOD FOR FORMING RESIST PATTERN AND METHOD FOR PRODUCING PRINTED WIRING BOARD - A photosensitive resin composition comprising: (A) a binder polymer; (B) a photopolymerizable compound that has an ethylenically unsaturated bond; and (C1) a compound represented by general formula (1) below, | 2010-11-11 |
20100285409 | METHOD FOR MANUFACTURING SEMICONDUCTOR DEVICE - A reverse pattern is formed once by combining a negative exposure mask having a wiring pattern with a positive resist, and then a positive wiring pattern is formed by use of the reverse pattern. That is, a positive resist applied on a semiconductor substrate is exposed by use of the exposure mask having an opening part in a region corresponding to the wiring pattern, and then the exposed part is removed by development to form a resist pattern, thereby forming the wiring pattern in the region corresponding to the opening part of the resist pattern. Consequently, it is hardly affected by flare during EUV exposure, thereby fabricating a fine wiring pattern with higher exposure latitude. | 2010-11-11 |
20100285410 | Method For Manufacturing A Semiconductor Device Using A Modified Photosensitive Layer - The present disclosure provides a method for manufacturing a semiconductor device. The method includes coating a photoresist on a substrate. The photoresist is exposed to radiation. The radiation exposed photoresist is baked. The radiation exposed and baked photoresist is developed to create an image pattern. The image pattern is treated with a treating material. An ion implantation process is performed to the substrate and the treated image pattern. The image pattern is stripped from the substrate. A carbon atom ratio of the treating material is less than a carbon atom ratio of the photoresist. | 2010-11-11 |
20100285411 | MICRO-FLUID EJECTION DEVICES WITH A POLYMERIC LAYER HAVING AN EMBEDDED CONDUCTIVE MATERIAL - Micro-fluid ejection devices, methods for making a micro-fluid ejection device, and methods for reducing a size of a substrate for a micro-fluid ejection head. One such micro-fluid ejection device has a polymeric layer adjacent a substrate and at least one conductive layer embedded in the polymeric layer. The polymeric layer comprises at least two layers of polymeric material. | 2010-11-11 |
20100285412 | METHOD FOR FABRICATING 3D MICROSTRUCTURE - A method for fabricating 3D microstructure is disclosed. A matching fluid is arranged between the mask and the photoresist layer. When the mask and photoresist layer perform the relative scanning and exposure process simultaneously, the matching fluid will reduce the diffraction error, so that the gap between the mask and the photoresist layer becomes more tolerable. Besides, the matching fluid also acts as a lubricant for achieving a smooth scanning process, so as to fabricate a high-precision large-area 3D optical microstructure. | 2010-11-11 |
20100285413 | Apparatus and Methods For Providing Uniformly Volume Distributed Combustion of Fuel - A combustor apparatus and method for the combustion of viscous fuels are provided. The combustor apparatus can include a precombustion chamber particularly adapted to heat and at least partially combust a heavy primary fuel, and a main combustion chamber adapted to combust the primary fuel uniformly through the main combustion chamber (in flameless mode). The precombustion chamber can include at least one air injection inlet port positioned to induce a first stage vortex in the main body portion of the housing of the precombustion chamber. Further, the precombustion chamber can be interfaced with a main combustion chamber to induce a second stage vortex within the main combustion chamber. The main combustion chamber can have an extended axial length in order to accommodate heavier fuels that require additional time to sufficiently combust (oxidize) within the combustion chamber. | 2010-11-11 |
20100285414 | FUEL SUPPLY DEVICE - A fuel supply device for generating mixed gas in which air and/or oxygen are mixed into fuel gas and supplying the mixed gas to a burning appliance comprises a flow rate control module disposed in a supply path of the fuel gas and flow rate control modules disposed in supply paths of the air and/or the oxygen. The flow rate control module includes a thermal mass flow rate sensor, a first calculator for calculating the thermal flow rate of the fuel gas from the output of the thermal mass flow rate sensor, a control computing unit for controlling the flow rate of the fuel gas via a flow rate regulating valve according to the calculated thermal flow rate, a second calculator for calculating the calculated calorific value per unit volume of the fuel gas, and a computing unit for computing the ratio of the calculated calorific value to the reference calorific value per unit volume of the fuel gas in a reference state. The ratio is used for the control of the flow rates of the air and/or oxygen by the flow rate control modules. | 2010-11-11 |
20100285415 | Burner Element and Burner Having Aluminum Oxide Coating and Method for Coating a Burner Element - A burner element is provided. The burner element includes a surface that potentially comes into contact with a fuel. The surface potentially coming into contact with the fuel has a coating including aluminum oxide. A burner including the burner element is also provided. Further, a method for coating a surface of a burner element potentially coming into contact with a fuel is described, wherein the surface potentially coming into contact with the fuel is coated with aluminum oxide. | 2010-11-11 |
20100285416 | Portable Catalytic Heating System for Off Grid Application - A portable catalytic heating system for off grid application, in which the heating system comprises a heating unit with a handle ( | 2010-11-11 |
20100285417 | System For Securing Intraoral Objects And Related Oral Structures - The present disclosure provides for a system for securing intraoral objects and related oral structures during a dental procedure, the system includes a predetermined length of wire having a first end portion and a second end portion; and a first sleeve defining a cavity for slidably engaging the first end portion of the wire therein wherein the engagement of the first sleeve to the wire enhances the strength of the wire without reducing the malleability thereof and increases the safety of a dental professional and patient during the dental procedure. The system may further include a second sleeve having a cavity for slidably engaging the second end portion of the wire therein. | 2010-11-11 |
20100285418 | ORTHODONTIC LIGATURE SYSTEMS AND METHODS - Ligature systems retain an arch wire within a slot of an orthodontic bracket. According to some embodiment, the ligature system retains an arch wire within a slot of an orthodontic bracket by means of a retaining element which is capable of being unidirectionally mechanically locked within the slot of the orthodontic bracket to retain an arch wire therewithin. The retaining element may comprise a pair of opposed outwardly projecting retaining edges. In some embodiments, the retaining element comprises a planar or curved retaining plate. The ligature system may include a central block in which the retaining plate is embedded such that the retaining edges extend outwardly therefrom. The ligature system may also include spike protruding outwardly from such central block so as to engage with the arch wire positioned subjacently thereto. In some embodiments of the invention, the retaining element is integral with the arch wire, while in other embodiments of the invention, the retaining element is integral with the slot in the orthodontic bracket. A dispenser may also provided according to the invention for dispensing individual ligature systems. | 2010-11-11 |
20100285419 | ORTHODONTIC ARTICLE HAVING PARTIALLY HARDENED COMPOSITION AND RELATED METHOD - An orthodontic article is provided for bonding to a tooth structure comprising an orthodontic appliance, a layer of partially hardened hardenable composition adjacent the appliance, and a bonding adhesive adjacent the partially hardened hardenable composition. A method of making an orthodontic article for orthodontic bonding is provided, comprising partially hardening a hardenable composition adjacent the base of an orthodontic appliance. | 2010-11-11 |
20100285420 | ORTHODONTIC BRACKET HAVING A LINGUALLY BIASED CLOSURE MEMBER AND ASSOCIATED METHOD - An orthodontic bracket includes a bracket body having an archwire slot configured to receive the archwire and a base surface that at least in part defines the archwire slot. A movable member is engaged with the bracket body and movable between an opened position and a closed position. A resilient member is configured to engage the movable member to impose a force that biases the movable member toward the base surface of the archwire slot. A method of moving a tooth includes inserting the archwire into the archwire slot, closing the movable member to capture the archwire within the archwire slot, and imposing a force on the movable member that biases the movable member toward the base surface of the archwire slot. | 2010-11-11 |
20100285421 | Self-Ligating Orthodontic Bracket - A self-ligating orthodontic bracket with a replaceable closing spring member detachably connected to the upper structure of a tooth-attachable base member. Particular preferred embodiments relate to the form of detachable connection of the closing spring member with the upper structure, with one particularly preferred embodiment being torsion tabs that are reversibly deformable to maintain pivoting engagement of spring member and upper structure when desired and easy removal of the spring members when desired. | 2010-11-11 |
20100285422 | LOW PROFILE ORTHODONTIC BITE CORRECTOR - A bite corrector for moving the relative positions of the jaws includes a telescoping assembly with an outer member and an inner member received in the outer member. The outer and inner members have matching, curved configurations. Both of the members remain in close proximity to the patient's dentition during opening and closing movement of the jaws and the likelihood of contact of the bite corrector with adjacent tissue in the patient's oral cavity is reduced. | 2010-11-11 |
20100285423 | Dental Hand-Held Instrument for Generating Measurement Results - A dental diagnostic system comprising a hand-held instrument that is equipped with means for detecting measured values and a transmission unit which is integrated into the housing and is used for wireless transmission of said measured values by means of infrared signals, and an external display and/or evaluation unit. The transmission unit of the hand-held instrument is designed in such a way that the infrared signals are emitted in at least two different directions. | 2010-11-11 |
20100285424 | DENTAL APPLICATOR DEVICE - A dental applicator device is disclosed. Generally, the dental applicator device includes a trough comprising a first wall, a second wall, and a floor, wherein at least one of the first wall, second wall, and floor comprises a contact surface, wherein at least a portion of the contact surface comprises a reticulated foam material. Methods of applying a dental agent to a target surface of a subject's dentition are also disclosed. Generally, the methods include providing a dental applicator device that includes a trough having a first wall, a second wall, and a floor, wherein at least one of the first wall, second wall, and floor comprises a contact surface, wherein at least a portion of the contact surface comprises a reticulated foam material, and a dental agent disposed in at least a portion of the trough; applying the dental applicator device to at least a portion of the subject's dentition for a time effective to transfer an effective amount of the dental agent to at least a portion of the target surface; and removing the dental applicator device. | 2010-11-11 |
20100285425 | Air activated impression syringe to deliver impression material around tooth in crown preparation - An air driven impression syringe designed to be held with a pen type grip and capable of precise placement of impression material. An embodiment of the device is a dental tool useful in the fabrication of dental prostheses capable of extruding impression material comprising a cylindrical grip body with two ends, an air-driven piston with a center rod; and | 2010-11-11 |
20100285426 | Coupling assembly, particularly for dental implants - A coupling assembly, particularly for dental implants, comprising at least one pin, which can be coupled rigidly to a bone portion, and a supporting element, which can be associated with a prosthesis. The pin has, at its end portion that lies opposite the one designed for connection to the bone portion, a protruding tab that can be accommodated by elastic forcing in a respective cavity formed in the supporting element so as to produce a stable coupling configuration between the pin and the supporting element. The tab is shaped like a substantially equatorial portion of a sphere with an outer lateral surface adapted to abut, with at least one part thereof, against the internal side wall of the cavity, to determine stable coupling configuration. | 2010-11-11 |
20100285427 | Dental implant fixture mount-abutment and ball impression screw - A dental implant fixture mount-abutment, comprising a fixture mount is a 2 to 7 mm coronal extension/metal collar at a coronal end for serving as an impression coping, temporary/permanent abutment and fixture mount, wherein the internal slots in said coronal end for receiving the fixture mount driver, wherein the driven channel in said coronal end for receiving a ball impression screw, wherein said the fixture mount has two small flat facets, located on opposite side of the fixture mount, extended between said coronal end and circumferential groove, an abutment which is a taper cylinder body having a shoulder and a circumferential curvature, wherein the shoulder on the abutment portion is a part of the abutment, wherein the circumferential curvature is designed to avoid engaging alveolar bone so as to be easily removed later, wherein said the abutment has two large flat facets, located on opposite side of the abutment, extended between said circumferential groove and shoulder, and the root of the DIFMA is a male connector for internally connecting to the dental implant, wherein the three engaging jaws, each of which has two stairs, protruded from the root for inserting and engaging in the engaging slots of the dental implant, wherein the two stairs are adapted to be inserted into the engaging slots of the dental implant | 2010-11-11 |
20100285428 | DENTAL IMPLANT THAT INCREASES BONE SUPPORT - This describes an implant design that increases the amount of bone around the implant by increasing its length in order to place a longer implant without the need for a sinus elevation surgery in the posterior maxillary region where bone stock is not sufficient by employing the principles of displacement procedures in implantology which rely on regeneration of patient's own bone and have been used for years in the dentistry for orthodontic procedures. The implant system we have designed has a pressure adaptor ( | 2010-11-11 |
20100285429 | COMPOUND SMC DENTAL MILL BLANKS - A dental mill blank is formed from a number of different self-supporting, malleable, curable (SMC) materials distributed within the blank so that a dental article machined from the blank closely resembles natural dentition in appearance or function. When in an uncured state, a single mill blank can be adapted to fit a variety of different tooth sizes and shapes, thus reducing the inventory of mill blank types required for fabrication of the range of possible tooth shapes and sizes. | 2010-11-11 |
20100285430 | APPARATUS, SYSTEMS, AND METHODS FOR APPLYING SPIN-ART TO FABRIC - A system, apparatus, and method for creating designs on an underlying material by spinning a platform on which the material is positioned while applying a coloring agent on the material through an aperture in an upper surface of a casing that houses the spinning platform. | 2010-11-11 |
20100285431 | CROCHETED YARN MODEL ENABLING EASY, QUICK AND UNIFORM HAND KNIT HANDICRAFT PROJECTS - The present invention a crocheted yarn model enabling persons to make easy, quick and uniform hand knit like handicraft projects. Users will be able to make handicraft projects easily and uniformly in a very short period of time without any special skill or expertise. | 2010-11-11 |
20100285432 | INTUITIVELY ORDERED TACTILE CHARACTERS READABLE BY VISUALLY IMPAIRED PERSONS - A reduced number of selectable inputs that enable efficient communication. Simplified tactile and optically machine readable code of raised embossments, particularly for unsighted and visually impaired persons is provided, in which each character is represented by a cell of indicia of an intuitive systematic code. For the alphabet, the cells are configured in ordered positions, which correspond to the order of the alphabet, and thereby, assist in tactile perception so that a person may easily identify the character by touch. Also, optical machines are enabled to easily read the characters; and a keyboard is provided for producing the same. | 2010-11-11 |
20100285433 | GOOD BEHAVIOR MOTIVATION GAME FOR CHILDREN AND METHOD OF USE - A game and method of play for motivating children to exhibit good behavior is disclosed. The game includes a game board, plural tickets, plural reward markers, and at least one bank. The board represents a store at which various real-world reward items may be acquired. Each token represents a predetermined value. The tokens are acquired in response to completing an assigned task or in response to taking an action exhibiting good behavior. The reward markers are arranged to be releasably secured to the board and represent a real-world reward that can be acquired by the child who accumulates a sufficient number of tickets equaling a redemption value of the reward marker. The bank is assigned to the child for receipt of acquired tokens and can be opened to remove the tokens for redemption so that the child may claim the real-world reward represented by the reward marker. | 2010-11-11 |
20100285434 | Automated Annotation - To automatically annotate an essay, a sentence of the essay is identified and a feature associated with the sentence is determined. In addition, a probability of the sentence being a discourse element is determined by mapping the feature to a model. The model having been generated by a machine learning application based on at least one annotated essay. Furthermore, the essay is annotated based on the probability. | 2010-11-11 |
20100285435 | METHOD AND APPARATUS FOR COMPLETION OF KEYBOARD ENTRY - A teaching machine generates a list of likely completions of an incomplete typed word, based upon previous keyboard input. This may include not only the incompletely typed word, but a number of completely typed, preceding words, in order have the word completion based upon context. The incompletely typed word is then subjected to a phonetic transcription, or other tests based upon knowledge by the system of the user, to further narrow the prediction list. | 2010-11-11 |
20100285436 | System, method, and apparatus for a portable, combination incubator, dehydrater, and micropropgation science unit - The present invention is a system, method that uses a cost-effective, portable, combination unit that can function as an incubator, dehydrator, and micro-propagation apparatus in the school classroom, at home, in an industrial setting, in a homeland security setting, in a forensic environment, and in the field for culturing, growing, blooming, propagating, and micro-propagating of various plants. In addition, the combination science unit can be use with bio-tissue. | 2010-11-11 |
20100285437 | DIDACTIC TOOLS FOR LEARNING MATHEMATICS - Didactic tools for learning mathematics contain a set of jigsaws, inserters, abacuses, three-dimensional arrangeable and separable models, mental maps, arranging pads, Multiplication tables without numbers, cylinders, and other spatially situated mathematical sizes and open the possibility of many combinations for arranging and displaying mathematical contents. These contents range from mathematical basis (relations, numbers and spaces, shapes and quantities) to theorems and rules of higher mathematical levels (multiplication, division, squaring, cubing, Pitagora's and binomial theorem, sum of square sequences and other regularities, some of which are new and unknown). With their inner consistency and coherence, they enable numerous combinations and research, and every tools can function independently in a clear and unambiguous way, based on natural mental abilities of logics and perception, close even to the earliest pre-school age. There is no need for additional instructions and lessons, or the knowledge of mathematical language, because the rules and relations are not proved by formulas, but are shown in a visible and tangible way. All this is achieved with a realistic display of quantities and their relations, the shape, position and colour, with the help of squares and cubeletes. It all enables arranging, categorizing, equalizing, joining, sequencing etc., so that adding or mere counting is sufficient for checking the visible quantities and their relations. They vividly enable discovery and understanding of mathematical laws by direct noting, by themselves. In that way they provide the joy of cognition, which enables more pleasurable, faster and easier understanding, practicing and memorizing. | 2010-11-11 |
20100285438 | Method And System For Minimally-Invasive Surgery Training - The present invention may be embodied as a method of minimally-invasive surgery (“MIS”) training wherein a simulator having a display, a computer, and a first input device, is provided. A video of an MIS is displayed on the display, and a first surgical tool is visible in at least a portion of the video. A match zone corresponding to a position on the first surgical tool is determined. A computer-generated virtual surgical tool (“CG tool”) is superimposed on the displayed video. The CG tool is selectively controlled by the first input device. A target position of the CG tool is determined. If the target position is not determined to be within the match zone, further steps may be taken. For example, the video may be paused, a message may be displayed to the operator, or the computer may signal the input device to move to a position such that the target position is within the match zone. | 2010-11-11 |
20100285439 | DEVICE FOR SIMULATING VARIABLE LUNG COMPLIANCE - Device for simulating variable lung compliance, comprising a structure having two main components ( | 2010-11-11 |
20100285440 | System and Method to Stimulate Human Genius - An interactive education system for stimulating higher cognitive processes of at least one user includes an interactive interface for communicating with at least one user, a feedback component includes an assessment module and a biofeedback module, a host processor includes a multimedia module. The multimedia module includes at least one teaching module and a storage module. The storage module performs at least one modification in the at least one teaching module of the multimedia module in response to data received from the assessment module and/or the biofeedback module and a communication network for coupling the feedback component to the host processor. | 2010-11-11 |
20100285441 | Global Computer Network Self-Tutoring System - A global computer network method and apparatus for creating and deploying many types of self-tutoring systems across many different platforms is disclosed. A run time engine supports several types of tutorials, in both a client and server context. A Builder enables development and testing of tutorials, formed of teacher composed problems, or an existing approved problems set, or student-user composed problems. The system simplifies the process of tutorial construction to allow educators and students with little or no ITS experience to develop content of problems and teaching strategies (i.e., format of problems including hints, messages and sequencing of related problems). The system provides a Web based interface as a means to build and store these tutorials. A web based reporting component allows for live database reporting to teachers, showing how students are performing. A testing component is web based and allows a teacher to test the quality of student composed problems. Further, the testing component allows addition of the student content to the existing approved problem set as is pertinent. Automated analysis and reporting of experimental tutorials developed by either teacher or student is included. | 2010-11-11 |
20100285442 | METHOD FOR APTITUDE TEST - An embodiment of the present invention provides a method for an aptitude test. The method includes receiving information concerning a request for an aptitude test service from the user terminal using the central server, and providing the aptitude test service to the user terminal using the central server, wherein the aptitude test service includes video content recorded in database. | 2010-11-11 |
20100285443 | Diagnostic Methods for Diseases Caused by a HPV Infection Comprising Determining the Methylation Status of the HPV Genome - Methods and kits for diagnosing and/or monitoring the progression of or otherwise staging a disease caused by a human papillomavirus (HPV) infection in a test sample obtained from a subject comprise determining the methylation status of a HPV genome. The presence of hypermethylation of the HPV genome indicates a positive diagnosis of the disease and/or an increased level of methylation of the HPV genome indicates the progression of the disease to a more advanced form. Suitable diseases linked to HPV infection include cancers such as cervical cancer. High risk HPV types such as HPV16 are generally assessed in the methods and using the kits of the invention. The HPV16 methylome is provided. | 2010-11-11 |
20100285444 | HBV precore protein capable of forming particles - There is provided a HBV precore protein having an ability of forming particles, and a means for determining it. A novel HBV precore protein that forms the virus (like) particles of HBV was identified. The present invention provides this novel HBV precore protein. Furthermore, there are provided core-like particles and virus-like particles formed by this HBV precore protein. These virus-like particles can be used for vaccines and therapeutic agents. The present invention also provides a method of determining the HBV precore protein and a method of determining the anti-HBV precore protein antibody. | 2010-11-11 |
20100285445 | CHIMERIC CONSTRUCT OF MUNGBEAN YELLOW MOSAIC INDIA VIRUS (MYMIV) AND ITS USES THEREOF - A recombinant DNA construct, recombinant vectors and host cells comprising the dimers of DNA A and DNA B of Mungbean Yellow Mosaic India Virus (MYMIV) in a single Ti plasmid are provided herein. | 2010-11-11 |
20100285446 | Methods for Detecting Metabolic States by Laser Ablation Electrospray Ionization Mass Spectrometry - According to certain embodiments, a method of mass spectrometry may generally comprise subjecting a sample comprising at least one indicator to laser ablation electrospray ionization mass spectrometry; determining a relative intensity of the indicator; and comparing the relative intensity of the indicator to a standard indicator intensity. Subjecting a sample to laser ablation electrospray ionization mass spectrometry may comprise ablating the sample with an infrared laser under ambient conditions to form an ablation plume; intercepting the ablation plume by an electrospray plume; and detecting the indicator by mass spectrometry. The method of mass spectrometry may comprise classifying the sample as belonging to or not belonging to the standard indicator intensity. A sample not belonging to the standard indicator intensity may indicate that the sample is predicted to comprise a disease state. | 2010-11-11 |
20100285447 | Methods for Antimicrobial Resistance Determination - The present invention relates to methods and systems for determining the antibiotic-resistance status of microorganisms. The invention further provides methods for determining the antibiotic-resistance status of microorganisms in situ within a single system. | 2010-11-11 |
20100285448 | RETROVIRAL NUCLEIC MATERIAL AND NUCLEOTIDE FRAGMENTS, IN PARTICULAR ASSOCIATED WITH MULTIPLE SCLEROSIS AND/OR RHEUMATOID ARTHRITIS, FOR DIAGNOSTIC, PROPHYLACTIC AND THERAPEUTIC USES - An isolated polynucleotide having a nucleotide sequence selected from the group consisting of (a) SEQ ID NO: 21, (b) the full-length sequences encoding a polypeptide having a peptide sequence selected from the group consisting of SEQ ID NOs: 25 and 26, and (c) the full-length complementary sequences to the sequences set forth in (a) or (b). | 2010-11-11 |
20100285449 | Human G-Protein Chemokine Receptor (CCR5) HDGNR10 - Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein chemokine receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein chemokine receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host. | 2010-11-11 |
20100285450 | COMPOSITIONS AND ASSAYS TO DETECT INFLUENZA VIRUS A AND B NUCLEIC ACIDS - Methods for detecting influenza virus A and influenza virus B nucleic acids in biological samples by using in vitro amplification and detection are disclosed. Compositions that are target-specific nucleic acid sequences and kits comprising target-specific nucleic acid oligomers for amplifying in vitro influenza virus A or influenza virus B nucleic acid and detecting amplified nucleic acid sequences are disclosed. | 2010-11-11 |
20100285451 | DETECTION OF SUB-CELLULAR COMPARTMENT LOCALIZATION OF A MOLECULE USING A REDUCED AFFINITY ENZYME COMPLEMENTATION REPORTER SYSTEM - Methods and compositions for detecting the sub-cellular localization of a molecule are provided. Aspects of the invention include detecting translocation of a cell-surface receptor to a sub-cellular compartment, e.g., the endosome, using a reduced affinity enzyme complementation reporter system. Also provided are systems and kits for use in practicing embodiments of the methods. | 2010-11-11 |
20100285452 | Molecular Markers for the Diagnosis and Treatment of Tumors - The invention relates to the diagnosis, prognosis, monitoring, and treatment of neoplastic diseases such as tumor diseases, especially tumor diseases of the endometrium and the metastases thereof. | 2010-11-11 |
20100285453 | CELL CULTURE ARTICLE AND METHODS THEREOF - A biosensor or cell culture article including: a substrate having a bio-compatible layer. The bio-compatible layer can be obtained from surface oxidation of a substrate coating comprising the reaction product of a suitable oxidizable polymer and modifier compound, such as a triamine, attached to the oxidizable polymer. Methods for making the biosensor or cell culture article and methods for performing an assay of a ligand with the biosensor article are also disclosed. | 2010-11-11 |
20100285454 | ENCLOSED UNIT FOR RAPID DETECTION OF A TARGET NUCLEIC ACID AMPLIFICATION PRODUCT - The invention relates to a method for rapid detection of a target nucleic acid amplification product while preventing cross-contamination between target nucleic acid amplification products and avoiding false positives, comprising the steps of: a) leaving the reaction tube unopened after the amplification reaction is finished, so as to prevent the target nucleic acid amplification product from leaking out and resulting in contamination; b) placing the unopened reaction tube inside an enclosed unit, making the target nucleic acid amplification product be transferred to a test strip from the reaction tube in a physically enclosed environment; c) performing detection in a visual read-out manner, and determining the result; d) discarding the enclosed unit in a safety place as a whole without opening it after the detection. The invention also relates to a totally enclosed unit for detecting a target nucleic acid amplification product, and still relates to applications of the totally enclosed rapid detection unit in detection of infectious pathogens, food industry, agriculture, livestock husbandry, customs quarantine control, and determination of DNA. | 2010-11-11 |
20100285455 | PREDICTION OF SCHIZOPHRENIA RISK USING HOMOZYGOUS GENETIC MARKERS - Provided are methods of identifying a genetic profile influencing the relative probability of a subject manifesting a phenotype that is at least partially heritable. Also provided are methods of determining the relative likelihood that a subject will manifest a phenotype that is at least partially heritable. Additionally, methods of determining the relative risk of a human subject for manifesting schizophrenia are provided. Further provided are methods of screening a human embryo in vitro for the risk of becoming a human manifesting schizophrenia. Also, methods of identifying a single nucleotide polymorphism (SNP) variant affecting the risk of a human subject for manifesting schizophrenia are provided. Methods of screening for a compound that may affect schizophrenia are additionally provided. | 2010-11-11 |
20100285456 | Method for using DNA repair capacity as a biomarker of breast cancer risk in women - Methods for the development of a breast cancer biomarker aimed at determining the risk of a woman to 1) develop breast cancer, 2) be free of breast cancer based on levels of overall DNA repair capacity as determined in blood lymphocytes. Examples on applicability of the methods to a human population are presented in terms of its potential for differential diagnosis, risk assessment and screening of breast cancer. | 2010-11-11 |
20100285457 | High-Throughput Diagnostic Assay For the Human Virus Causing Severe Acute Respiratory Syndrome (SARS) - The present invention relates to a high-throughput diagnostic assay for the virus causing Severe Acute Respiratory Syndrome (SARS) in humans (“hSARS virus”). In particular, the invention relates to a high-throughput reverse transcription-PCR diagnostic test for SARS associated coronavirus (SARS-CoV). The present assay is a rapid, reliable assay which can be used for diagnosis and monitoring the spread of SARS and is based on the nucleotide sequences of the N (nucleocapsid)-gene of the hSARS virus. The present method eliminates false negative results and provides increased sensitivity for the assay. The invention also discloses the S (spike)-gene of the hSARS virus. The invention further relates to the deduced amino acid sequences of the N-gene and S-gene products of the hSARS virus and to the use of the N-gene and S-gene products in diagnostic methods. The invention further encompasses diagnostic assays and kits comprising antibodies generated against the N-gene or S-gene product. | 2010-11-11 |
20100285458 | Gene Expression Profiling for Identification, Monitoring, and Treatment of Lupus Erythematosus - A method is provided in various embodiments for determining a profile data set for a subject with lupus or conditions related to lupus based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount of RWA corresponding to at least one constituent from Tables 1-7, 9-13, and 15-20. The profile data set comprises the measure of each constituent, and amplification is performed under measurement conditions that are substantially repeatable. | 2010-11-11 |
20100285459 | Human Diabetes Susceptibility TNFRSF10A gene - The present invention relates to a diagnostic method of determining whether a subject is at risk of developing type 2 diabetes, which method comprises detecting the presence of an alteration in the TNFRSF10A gene locus in a biological sample of said subject. | 2010-11-11 |
20100285460 | Biological Detection System and Method - The present disclosure, according to some embodiments, relates to phage-based biological detection systems, compositions, and methods. In some embodiments, it relates to a detection system and method using phage binding and bacterial infection to detect the presence of a target molecule (e.g., a toxin). One detection system may include a genetically engineered phage that expresses a surface molecule able to bind a target molecule and/or target microorganism; a bacterium susceptible to infection by the phage; and a detection component able to determine whether the bacterium has been infected by the phage. Infection of a bacterium by a phage may be indicative of phage binding to the target molecule and/or target microorganism. One method may include placing a sample suspected of containing the target molecule and/or target microorganism with a binder; adding a genetically engineered phage having reporter genetic material and able to bind the target molecule and/or target microorganism; washing away unbound phage; releasing phage bound to the target molecule and/or target microorganism; infecting a bacterium with the released phage; and detecting the presence of any reporter genetic material in the bacterium. Reporter material in the bacterium may correlate with target molecule and/or target microorganism in the sample. In some embodiments, the disclosure relates to a detection system and method using phage comprising a reporter to infect a microorganism (e.g., | 2010-11-11 |
20100285461 | Methods Of Producing And Sequencing Modified Polynucleotides - The present invention encompasses methods for producing a modified polynucleotide sequence that comprises a (e.g., one or more) phosphorothiolate linkage, methods for determining a polynucleotide sequence comprising a (e.g., one or more) phosphorothiolate linkage, and methods for separating forward and reverse extension products that comprise a (e.g., one or more) phosphorothiolate linkage. The invention also encompasses kits for producing and/or determining the sequence of a modified polynucleotide that comprises a (e.g., one or more) phosphorothiolate linkage. | 2010-11-11 |
20100285462 | METHODS AND MATERIALS RELATED TO HAIR PIGMENTATION AND CANCER - This document relates to methods and materials for determining whether or not a horse contains a Grey allele. For example, diagnostic methods such as nucleic acid-based detection methods and materials such as nucleic acid probes and primer pairs that can be used to determine whether or not a horse contains a duplication in intron 6 of STX17 nucleic acid are provided. This document also relates to methods and materials for treating a mammal having or being likely to develop cancer (e.g., benign, malignant, or metastatic cancer). For example, methods and materials for treating cancer in a mammal by administering an agent having the ability to reduce expression of an STX17 polypeptide and/or an NR4A polypeptide (e.g., an NR4A1, NR4A2, or NR4A3 polypeptide) in the mammal are provided. | 2010-11-11 |
20100285463 | SELECTING NUCLEIC ACID SAMPLES SUITABLE FOR GENOTYPING - The present invention relates to a method for selecting a DNA sample comprising genomic DNA suitable for genotyping, comprising the steps of: i) pre-genotyping said genomic DNA using a set of polymorphic markers; ii) determining out of said set of polymorphic markers the percentage of polymorphic markers for which said genomic DNA is homozygous; and iii) selecting said DNA sample when said genomic DNA is homozygous for less than 70% of said set of polymorphic markers. Furthermore, a method of genotyping comprising a step of using a DNA sample selected by the method in accordance with the present invention and/or a step of applying the method provided herein is disclosed. The present invention also relates to a method for identifying a gene or a locus on a genome, said method comprising a step of using a DNA sample selected by the method provided herein and a step of applying the method described herein. Further, the present invention relates to a kit for carrying out the method in accordance with the present invention comprising primers for the amplification of the set of polymorphic markers employed herein. | 2010-11-11 |
20100285464 | A CONSERVED REGION OF THE HIV-1 GENOME AND USES THEREOF - The present invention discloses sequences having a structure and sequence homology to lox-P recombinase target site corresponding to a highly conserved region within the Long Terminal Repeats (LTR) of HIV and to the use thereof for the identification of recombinase enzymes useful in treating HIV-1. | 2010-11-11 |
20100285465 | Molecular Typing of Neisseria Strains by Determining the Presence of Genes Involved in Lipooligosaccharide (LOS) Biosynthesis - The present invention relates to a method of LOS molecular typing of a | 2010-11-11 |
20100285466 | ESOPHAGEAL CANCER MARKERS - The present invention is directed to methods for diagnosing cancer in a subject. Morphologically normal epithelial cells of the esophagus are assayed for marker expression. Characteristic expression of the markers indicates the presence of cancer or the predisposition to cancer. A panel of eleven markers are particularly good at identifying cancer and the predisposition to cancer. | 2010-11-11 |
20100285467 | RAPID AND SENSITIVE METHOD FOR DETECTION OF BIOLOGICAL TARGETS - The present invention relates to a method of biological labeling that occurs via a free radical chain reaction. The labeling occurs due to deposition of a detectable reporter molecule from a media comprising a substance comprising at least two moieties of a peroxidase enzyme substrate (termed herein ‘cross-linker’) in a target site comprising peroxidase activity and a biological marker. The labeling reaction described herein may generally be used to detect targets in a host of experimental schemes for detecting and visualizing a biological or chemical target, including immunohistochemistry (IHC), in situ hybridization (ISH), antibody-based staining methods such as ELISA, Southern, Northern, and Western blotting, and others. | 2010-11-11 |
20100285468 | DETECTION AND/OR QUANTIFICATION OF NUCLEIC ACIDS - The present invention provides compositions, methods, and kits for nucleic acids analyses. In particular, melting analyses are used to detect the presence or absence and to quantify nucleic acids. | 2010-11-11 |
20100285469 | METHOD OF TUMOR SCREENING - A method for tumor screening using urine of a mammal, the method includes obtaining a total urine nucleic acid (e.g., DNA) from a urine sample of a mammal, extracting a high molecular weight urine nucleic acid (above 1000 bp) by contacting the total urine nucleic acid with an adsorbent in the presence of a buffer which promotes binding of the high molecular weight urine nucleic acid to the adsorbent, replacing the buffer which promotes binding of the high molecular weight urine nucleic acid with a buffer which promotes binding of the low molecular weight urine nucleic acid to the adsorbent, extracting the low molecular weight urine nucleic acid by contacting with the adsorbent, eluting the low molecular weight urine nucleic acid, and assaying the low molecular weight urine nucleic acid for a presence or absence of a gene sequence specific to a certain type of tumor. | 2010-11-11 |
20100285470 | MONOMETHINE DYES - Monomethine dyes that have no or minimal fluorescence in buffer or in the presence of single stranded DNA or RNA, but strongly fluoresce in the presence of double-stranded DNA. In one embodiment, the dye is useful in quantitative RT-PCR. | 2010-11-11 |
20100285471 | Methods and Compositions for the Diagnosis and Treatment of Esphageal Adenocarcinomas - Methods and compositions for the diagnosis, prognosis and/or treatment of esophageal adenocarcinoma and Barrett's esophagus associated adenocarcinoma are disclosed, along with more markers where a difference is indicative of esophageal adenocarcinoma and squamous cell carcinoma, and/or Barrett's esophagus associated adenocarcinomas or a predisposition thereto. The invention also provides methods and compositions of identifying anti-cancer agents therefor. | 2010-11-11 |
20100285472 | PRIMERS AND PROBES FOR DETECTION OF HIGH RISK GROUP GENO-TYPE HUMAN PAPILLOMAVIRUS DNA, A QUALITATIVE ASSAY METHOD OF THE SAME DNA USING THEM AND A QUALITATIVE ASSAY KIT OF THE SAME DNA - The present invention relates to a method for qualitative assay of high risk group Human Papillomavirus (HPV) DNA by PCR method using primers designed to detect the infection of 13 high risk group HPV which are closely associated with cervical cancer in a simple and precise way, and a kit for qualitative assay of high risk group HPV DNA. | 2010-11-11 |
20100285473 | THERMOPHILIC HELICASE DEPENDENT AMPLIFICATION TECHNOLOGY WITH ENDPOINT HOMOGENOUS FLUORESCENT DETECTION - Disclosed herein are methods of amplifying a target nucleic acid in a helicase-dependent reaction. Also disclosed are methods of amplifying and detecting a target nucleic acid in a helicase-dependent reaction as well as modified detection labels to assist in the detection. | 2010-11-11 |
20100285474 | DIAGNOSTIC, PREDICTIVE AND PROGNOSTIC TESTING FOR CANCER - The present invention relates to a method for determining a prognosis of progression of a cancer in a subject, a method for determining a treatment protocol for a subject having cancer or a method for determining efficacy of a therapeutic treatment of a subject, the method comprising the steps of:
| 2010-11-11 |
20100285475 | FUSED GENES - There is provided at least one isolated fused gene comprising at least one first gene and/or fragment thereof fused to at least one second gene and/or fragment thereof, wherein at least the first and/or the second gene, independently, is selected from the group consisting of: RCC2, CENPF, ARFGEF2, SULF2, MTAP, ATXN7, BCAS3, RPS6KB1, TMEM49, EAP30, a gene having the nucleotide sequence SEQ ID NO:1, and a gene having the nucleic acid SEQ ID NO:2, or a fragment thereof. There is also provided a diagnostic method and/or a kit for detecting the susceptibility, prognosis, and/or to tumour in a subject. | 2010-11-11 |
20100285476 | METHODS OF IDENTIFYING HISTONE DEACETYLASE INHIBITORS USEFUL FOR NEUROLOGICAL DISORDERS - A method of identifying a candidate compound for treatment of a neurological condition includes obtaining a test compound; assaying a first activity of the test compound to inhibit histone deacetylase activity of a histone deacetylase 3 (HDAC3); assaying a second activity of the test compound to inhibit histone deacetylase activity of a histone deacetylase other than a HDAC3; and identifying the test compound as a candidate compound for treatment of a neurological condition if the first activity of the test compound is greater than the second activity of the test compound. | 2010-11-11 |
20100285477 | Method for Predicting the Response to a Therapy - The invention concerns an in vitro method for selecting the therapy for a steroid resistant patient, wherein the method comprises isolating cells from a sample taken from said patient; cultivating said isolated cells in the presence of a steroid, an immunomodulatory oligonucleotide or a mixture thereof; determining an expression level of at least one marker gene in said isolated cells; and comparing said expression level of said at least one marker gene to a value obtained from the cultivation of cells from a healthy person in the presence of a steroid, an immunomodulatory oligonucleotide or a mixture thereof, or to a normalized value obtained from a healthy population. Examples of marker genes are CD163, Tsp1, IL1-R2, TLR2, TLR4, MKP-1 and TXK. | 2010-11-11 |
20100285478 | Methods, Compositions, and Kits for Detecting Allelic Variants - In some embodiments, the present inventions relates generally to compositions, methods and kits for use in discriminating sequence variation between different alleles. More specifically, in some embodiments, the present invention provides for compositions, methods and kits for quantitating rare (e.g., mutant) allelic variants, such as SNPs, or nucleotide (NT) insertions or deletions, in samples comprising abundant (e.g., wild type) allelic variants with high specificity and selectivity. In particular, in some embodiments, the invention relates to a highly selective method for mutation detection referred to as competitive allele-specific TaqMan PCR (“cast-PCR”). | 2010-11-11 |
20100285479 | SYSTEMS AND METHODS FOR POINT-OF-CARE AMPLIFICATION AND DETECTION OF POLYNUCLEOTIDES - Composition and methods for amplifying and detecting solution-state polynucleotide targets in a single device are described. In one aspect, a method for a coupled isothermal amplification and detection process utilizes a coated solid support, including a solid substrate, a cationic layer, and a plurality of target-specific probes attached to the coated solid support. Polynucleotide targets in the sample are amplified by an isothermal amplification process involving in situ hybridization onto the coated solid support. The entire process can be carried out with a high degree of specificity under low salt conditions in less than one hour. Further aspects of the present invention include methods for coupled hybridization/detection of polynucleotide targets, coated silicon biosensors optimized for use with the coupled detection systems to provide visual detection of polynucleotide targets under visible light conditions, and kits for practicing in the above described methods. | 2010-11-11 |
20100285480 | TCL-1 GENE AND PROTEIN AND RELATED METHODS AND COMPOSITIONS - The present invention relates to nucleotide sequences of TCL-1 genes and amino acid sequences of their encoded proteins, as well as derivatives and analogs thereof, and antibodies thereto. The TCL-1 gene sequence is preferentially expressed early in T and B lymphocyte differentiation. The present invention further relates to the use of TCL-1 genes and their encoded proteins as diagnostic and therapeutic reagents for the detection and treatment of disease states associated with chromosomal abnormalities. | 2010-11-11 |
20100285481 | METHODS FOR NUCLEIC ACID MANIPULATION - A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The recombination intermediate is treated with a high fidelity polymerase to permit the replication and amplification of the target nucleic acid sequence. In preferred embodiments, the polymerase comprises a polymerase holoenzyme. In further preferred embodiments, the recombination factor is bacteriophage T4 UvsX protein or homologs from other species, and the polymerase holoenzyme comprises a polymerase enzyme, a clamp protein and a clamp loader protein, derived from viral, bacteriophage, prokaryotic, archaebacterial, or eukaryotic systems. | 2010-11-11 |
20100285482 | METHODS FOR NUCLEIC ACID MANIPULATION - A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The recombination intermediate is treated with a high fidelity polymerase to permit the replication and amplification of the target nucleic acid sequence. In preferred embodiments, the polymerase comprises a polymerase holoenzyme. In further preferred embodiments, the recombination factor is bacteriophage T4 UvsX protein or homologs from other species, and the polymerase holoenzyme comprises a polymerase enzyme, a clamp protein and a clamp loader protein, derived from viral, bacteriophage, prokaryotic, archaebacterial, or eukaryotic systems. | 2010-11-11 |
20100285483 | Molecular diagnostic method and treatment in dementia with Lewy bodies - The invention describes methods of molecular diagnosis of a concrete form of α-synucleinopathy, the dementia with Lewy bodies (DLB), associated to the levels of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) or the alteration of its ubiquityl-ligase activity. It also refers to the use of compounds that permit the modification of the UCH-L1 levels or of the enzymatic activity of UCH-L1. This invention has application in the diagnosis and treatment of patients suffering from DLB. | 2010-11-11 |
20100285484 | APOPTOSIS INDUCING POSITIVE CONTROL FOR EXPRESSION MODULATION EXPERIMENTS - The invention pertains to a method for performing an expression modulating analysis or assay, wherein an apoptosis inducing expression modulating compound targeting a repetitive element present in the untranslated region, in particular the 3′ UTRs of protein coding gene transcripts is introduced into cells to induce apoptosis in the cells as a positive control. Also provided are suitable kits and compositions. | 2010-11-11 |
20100285485 | PRIMER, PROBE, DNA CHIP CONTAINING THE SAME AND METHOD FOR DETECTING HUMAN PAPILLOMAVIRUS AND DETECTION KIT THEREOF - The present invention discloses a primer, a probe, a DNA chip, and a test kit for diagnosis and genotyping of Human Papilloma Virus (HPV) as well as a method for testing HPV genotype. According to the present invention, it is possible to screen HPV genotypes with high sensitivity and specificity, and to diagnose infection by multiple HPV types which was not possible in other conventional HPV testing methods | 2010-11-11 |
20100285486 | Non-Invasive Detection of Bladder Cancer by Fluorescence in Situ Hybridization of Aurora A - We disclose a method of detecting bladder cancer in a patient, comprising isolating bladder cells from the patient's urine; hybridizing the bladder cells with a labelled DNA probe, wherein the probe recognizes at least a portion of the aurora kinase A gene, to yield a sample of bladder cells hybridized with the labeled DNA probe; and counting the number of bladder cells in the sample, the number of copies of the aurora kinase A gene in each bladder cell in the sample, and the number of bladder cells in the sample having at least a first threshold number of copies of the aurora kinase A gene. | 2010-11-11 |
20100285487 | FLUORESCENT TWO-HYBRID (F2H) ASSAY FOR DIRECT VISUALIZATION OF PROTEIN INTERACTIONS IN LIVING CELLS - The present invention relates to an in vitro method for detecting protein-protein interactions comprising: (a) expressing in a eukaryotic cell a first fusion protein comprising (i) a (poly)peptide that, when expressed in a cell, accumulates at distinct sites in the nucleus of the cell or interacts with proteinaceous or non-proteinaceous structures accumulated at distinct sites in the nucleus of the cell; and (ii) a (poly)peptide specifically binding to GFP; (b) expressing in the same cell a second fusion protein comprising (i) GFP; and (ii) a bait (poly)peptide; (c) expressing in the same cell a third fusion protein comprising (i) a fluorescent (poly)peptide, the excitation and/or emission wavelength of which differs from that of GFP; and (ii) a prey (poly)peptide; and (d) detecting the fluorescence emission of the fluorescent parts of the second and the third fusion protein in the cell upon excitation, wherein a co-localization of the fluorescence emission of both fusion proteins in the cell nucleus is indicative of an interaction of the bait and the prey (poly)peptide. The invention also relates to an in vitro method for detecting protein-protein interactions comprising: (a) expressing in a eukaryotic cell a first fusion protein comprising (i) a fluorescent (poly)peptide; (ii) a (poly)peptide that, when expressed in a cell, accumulates at distinct sites in the nucleus of the cell; and (iii) a bait (poly)peptide (b) expressing in the same cell a second fusion protein comprising (i) a fluorescent (poly)peptide, the excitation and/or emission wavelength of which differs from that of the fluorescent (poly)peptide comprised in said first fusion protein; and (ii) a prey (poly)peptide and (c) detecting the fluorescence emission of the fluorescent parts of the first and the second fusion protein in the cell upon excitation, wherein a co-localization of the fluorescence emission of both fusion proteins in the cell nucleus is indicative of an interaction of the bait and the prey (poly)peptide. Furthermore, the present invention relates to methods for identifying a compound modulating the interaction of two (poly)peptides and methods of determining the relative strength of the interaction of two proteins with a third protein. | 2010-11-11 |
20100285488 | T-STRUCTURE INVASIVE CLEAVAGE ASSAYS, CONSISTENT NUCLEIC ACID DISPENSING, AND LOW LEVEL TARGET NUCLEIC ACID DETECTION - The present invention relates to systems, methods and kits for low-level detection of nucleic acids, detecting at least two different viral sequences in a single reaction vessel, and increasing the dynamic range of detection of a viral target nucleic acid in a sample. The present invention also relates to T-structure invasive cleavage assays, as well as T-structure related target dependent non-target amplification methods and compositions. The present invention further relates to methods, compositions, devices and systems for consistent nucleic acid dispensing onto surfaces. | 2010-11-11 |
20100285489 | METHOD FOR DIAGNOSING RENAL DISEASES OR PREDISPOSITIONS - The invention provides a method of diagnosing a disease or a predisposition to contract a disease by assaying for mutations of uromodulin (UMOD) within a test subject or patient. The presence of a mutation in the UMOD supports a diagnosis of a disease or a predisposition to contract a disease within the patient. | 2010-11-11 |
20100285490 | DETECTION APPARATUS - The present invention relates to, in part, methods, reagents and apparatuses for the detection of agents. The present invention also relates, in part, to compositions including, but not limited to, flow cells, assay chambers, reagent reservoir delivery units and devices for holding an assay chamber. The present invention also provides various components and combinations of components for various detection apparatuses. The present invention also relates to a portable agent detection apparatus that can be used in the field or at a point of care and is not limited to specialized laboratories or limited to use by highly skilled users. | 2010-11-11 |
20100285491 | USE OF IGFBP-7 IN THE ASSESSMENT OF HEART FAILURE - The invention relates to a method for assessing heart failure in vitro comprising the steps of measuring in a sample the concentration of the marker IGFBP-7, of optionally measuring in the sample the concentration of one or more other marker(s) of heart failure, and of assessing heart failure by comparing the concentration determined in for IGFBP-7 and the concentration(s) determined for the optionally one or more other marker to the concentration of this marker or these markers as established in a reference population. Also disclosed are the use of IGFBP-7 as a marker protein in the assessment of heart failure, a marker combination comprising IGFBP-7 and a kit for measuring IGFBP-7. | 2010-11-11 |
20100285492 | USE OF SLIM-1 IN THE ASSESSMENT OF HEART FAILURE - The invention relates to a method for assessing heart failure in vitro comprising the steps of measuring in a sample the concentration of the marker SLIM-1, of optionally measuring in the sample the concentration of one or more other marker(s) of heart failure, and of assessing heart failure by comparing the concentration determined in for SLIM-1 and the concentration(s) determined for the optionally one or more other marker to the concentration of this marker or these markers as established in a reference population. Also disclosed are the use of SLIM-1 as a marker protein in the assessment of heart failure, a marker combination comprising SLIM-1 and a kit for measuring SLIM-1. | 2010-11-11 |
20100285493 | METHOD FOR DETERMINING AMINO-TERMINAL PROANP IN PATIENTS HAVING A CARDIAC DISEASE OR BEING SUSPECTED OF DEVELOPING OR HAVING A CARDIAC DISEASE - The present invention relates to an in vitro method for medical diagnosis, prognosis and therapy follow-up for patients having a cardiac disease or being suspected of developing or having a cardiac disease comprising the steps of: providing a sample of a patient having a cardiac disease or being suspected of developing or having a cardiac disease, determining amino-terminal proANP or partial peptides thereof having from 12 to 98 amino acids in said sample using at least one antibody that binds specifically to a partial sequence of amino-terminal proANP, attributing the determined amino-terminal proANP level or the level of partial peptides thereof to a clinical picture wherein the attribution is carried out independent of the BMI of the patient. The present invention further concerns a rapid test assay and a kit for conducting the method of the present invention and the use of antibodies suitable for the method and assays according to the present invention. | 2010-11-11 |
20100285494 | COMBINATION THERAPY FOR THE TREATMENT OF DIABETES AND CONDITIONS RELATED THERETO AND FOR THE TREATMENT OF CONDITIONS AMELIORATED BY INCREASING A BLOOD GLP-1 LEVEL - The present invention concerns combination of an amount of a GPR119 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a blood glucose level or in increasing a blood GLP-1 level in a subject over that provided by the amount of the GPR119 agonist or the amount of the DPP-IV inhibitor alone and the use of such a combination for treating or preventing diabetes and conditions related thereto or conditions ameliorated by increasing a blood GLP-1 level. The present invention also relates to the use of a G protein-coupled receptor to screen for GLP-1 secretagogues. | 2010-11-11 |