45th week of 2011 patent applcation highlights part 37 |
Patent application number | Title | Published |
20110275019 | HARDMASK COMPOSITION HAVING ANTIREFLECTIVE PROPERTIES AND METHOD OF PATTERNING MATERIAL ON SUBSTRATE USING THE SAME - A hardmask composition includes an organic solvent and one or more aromatic ring-containing polymers represented by Formulae 1, 2 and 3: | 2011-11-10 |
20110275020 | Methods Of Forming Photoresist Patterns - Methods of forming photoresist patterns may include forming a photoresist layer on a substrate, exposing the photoresist layer using an exposure mask, forming a preliminary pattern by developing the exposed photoresist layer and treating a surface of the preliminary pattern using a treatment agent that includes a coating polymer. | 2011-11-10 |
20110275021 | SILVER HALIDE PHOTOGRAPHIC LIGHT-SENSITIVE MATERIAL FOR MOVIE - A silver halide photographic light-sensitive material for movie, having a specific layer structure by using particles of at least one kind of electroconductive metal oxide and at least one kind of an electroconductive polymer. | 2011-11-10 |
20110275022 | Pilot Light Gas Line Connector Assembly - Pilot light gas line connector assemblies and methods for cleaning a pilot light orifice are disclosed herein. An exemplary connector assembly for coupling to a pilot light gas line and cleaning a pilot orifice has a first fitting end, a second fitting end, and a passageway therebetween. The first fitting end is adapted to receive a first end of the pilot light gas line and the second fitting end is adapted to receive a valve capable of directing forced air from a forced air source into the second fitting end. Methods of cleaning a pilot orifice of a pilot light system include removing the pilot light gas line from a gas port and coupling the pilot light gas line to a pilot light gas line connector assembly. Then forced air is directed into the connector assembly and through pilot light gas line thereby cleaning the pilot orifice. | 2011-11-10 |
20110275023 | Convection Oven - An oven for cooking foods includes a housing having a fire chamber and a cooking chamber disposed generally above the fire chamber. A vessel is receivable in the fire chamber and is adapted to hold combustible material therein to generate heat and smoke for cooking food in the cooking chamber. A blower is mounted on the housing. The blower is selectively operable to move air. A tube is attached to an outlet of the blower and extends into the fire chamber such that when the vessel is received in the fire chamber the tube extends to a position adjacent the vessel so that air from the blower is blown directly into the vessel without first passing a heating element. The oven does not require supplemental heat from a burner or similar heating element. | 2011-11-10 |
20110275024 | HEAT TREATMENT APPARATUS AND HEAT TREATMENT METHOD - The present invention relates to a heat treatment apparatus and a heat treatment method that control temperature distribution during cooling. There is provided a cooling step in which a heated treatment object is cooled using a cooling liquid in mist form, and heat treatment is performed by alternatingly repeating a first step (K | 2011-11-10 |
20110275025 | CIRCUIT BOARD FOR CONTROLLING WIRELESS DENTAL FOOT PEDAL - A system, method, and apparatus including a printed circuit board with electronic circuit components mounted thereon and configured for wireless communication between the various components and devices used in a wireless dental device. | 2011-11-10 |
20110275026 | SYSTEMS AND METHODS FOR PROVIDING A DECORATIVE DENTAL TIP - A decorative dental tip is provided for a dental syringe. The decorative dental tip includes a molded, outer surface portraying an object selected to alleviate an anxiety of a patient. The dental tip further includes a molded, inner lumen in fluid communication with a dental syringe. | 2011-11-10 |
20110275027 | SYSTEM INCLUDING A WIRELESS DENTAL INSTRUMENT AND UNIVERSAL WIRELESS FOOT CONTROLLER - A wireless, remote foot controller and a wireless instrument in direct communication with one another and method of operation. The remote foot controller can determine the wireless instrument in the hand of the dental professional and can determine whether the instrument is operational in an continuously variable mode or whether the instrument is operational at discrete speeds. The remote foot controller can then respond to activation by a user to provide a predetermined signal that drives the handheld unit with the appropriate signal. The remote foot controller is activated by application of pressure to the foot controller that provides tactile, sensory feedback to the user. The foot controller includes a circuit board, antenna and battery so that it is wireless. The circuit board includes communications protocol to permit the foot controller to communicate with several dental instruments. Although the foot controller is capable of controlling multiple dental instruments, it only controls one dental instrument at a time, usually the most recent device in the hands of the dental professional. | 2011-11-10 |
20110275028 | GINGIVAL TISSUE RETRACTION DEVICE AND METHOD - A method and a device for effecting the cordless retraction of the gingival sulcus tissue that includes a dam shaped to be fitted onto a tooth. In one embodiment, the well of the dam is pre-filled with a predetermined amount of a flowable retraction material having a heavy viscosity or putty consistency. In another embodiment a hydrophilic material is added. The preloaded tooth dam is fitted to a prepared tooth so that when pressure is applied onto the tooth dam, the retraction material is displaced under pressure and forced into the sulcus, causing the gingival tissue to retract away from the tooth to enlarge the gingival sulcus. In another embodiment the cap is filled with a dilatant material. In another embodiment, the cap is filled with an impregnated compressible porous material. In yet another embodiment, the cap is pre-dosed with an astringent or hemostatic agent. | 2011-11-10 |
20110275029 | DESIGN METHOD OF SURGICAL SCAN TEMPLATES AND IMPROVED TREATMENT PLANNING - In implant dentistry, scan templates, also known as scan appliances or radiographic guides, are fabricated according to patients' anatomy, and later on transferred into surgical guides through CT scan, image segmentation, surface reconstruction, CAD modification, and manufacturing. This approach may be also applied to other kinds of surgery. The final manufactured surgical guides can hardly match the actual geometry of the initial scan templates, thus cannot fit well into patients' mouths, which can pose serious risks for surgery. | 2011-11-10 |
20110275030 | DENTAL IMPLANT - Dental implant, comprising an abutment ( | 2011-11-10 |
20110275031 | METHOD OF PRODUCING A DENTAL RESTORATION, DENTAL RESTORATION AND USE THEREOF - The invention relates to a method of producing a dental restoration ( | 2011-11-10 |
20110275032 | METHOD AND DEVICE FOR PLACING DENTAL IMPLANTS - The invention relates to a method and device for placing implants using a surgical template which is made from tomographic cuts in the patient's jawbone. Step drills and calibrating drills, having a single standard diameter for each type of implant, are guided through drill bushings which are inserted into bores in the template in order to produce any drilling sequence corresponding to an implant plan. The penetration depth of the drills is controlled by the height of the bores or by the drill rings. The method limits the required number of drills and implant supports to the longest models only. The inventive method and device are particularly suitable for computer-assisted implantology systems. | 2011-11-10 |
20110275033 | Palladium-Cobalt Based Alloys - A nonmagnetic alloy is provided based on a palladium-cobalt binary system with the addition of gold, has a coefficient of thermal expansion (CTE) of about 13.8 to about 15 and may include one or more of the following additive metals: aluminum, boron, chromium, gallium, lithium, rhenium, ruthenium, silicon, tantalum, titanium, and tungsten. | 2011-11-10 |
20110275034 | METHOD AND APPARATUS FOR DETECTION OF CARIES - A method for forming an enhanced image ( | 2011-11-10 |
20110275035 | DENTAL COMPOSITIONS - A self-etching and self-adhesive dental restorative composition is described herein. The composition includes a polymerizable compound having at least one phosphorus containing acidic group, a polymerizable compound having at least one carboxylic acid group, and a copolymerizable multi-functional (meth)acrylate monomers. Compositions described herein demonstrate adhesion to dentin and enamel and are useful as a cavity filler, dental pit and fissure sealants, and restoratives. | 2011-11-10 |
20110275036 | RECOIL SYSTEM FOR FIREARMS | 2011-11-10 |
20110275037 | SYSTEM AND METHOD OF TRANSLITERATING NAMES BETWEEN DIFFERENT LANGUAGES - Both a system and method are provided for transliterating a name written in the letters of an alphabet of a source language to a name in the letters of an alphabet of a target language that is different from the source language. The system includes a CPU, a computer readable memory and a computer readable storage media; and first, second and third program instructions. The first program instructions determine whether the letters of the alphabets of the source and target languages are the same or substantially the same. If so, the second program instructions transliterate the name into the same letters used in the source language alphabet. If not, the third program instructions (1) determine the sound associated with each of the letters of the source language that form the name; (2) transliterate the letters of the name in the source language into letters of the International Phonetic Alphabet (IPA) to create a same or similar sounding name in the letters of the IPA; (3) determine the sound associated with each of the letters of the target language, and (4) transliterate the letters of the IPA form of the name into letters of the target language to create a same or similar sounding name in the letters of the target language. | 2011-11-10 |
20110275038 | Educational Math Game - An educational game for mathematics has a poly outline or spherical shape board with a continuous play path along its edge and is labeled with different mathematical strands. Strands include question cards, segments labeled as mathematical concepts, and a monetary amount. Game pieces are included but are not part of the game board itself. When a player tosses a positive integer with both dice (E.g. cube subtracted from decahedron) and lands on a segment, he/she will receive credit for correctly answering a strand card question. If the dice toss result is negative, he/she may not attempt a question. If segments are credited to other players, he/she must pay a penalty derived from a mathematical equation. Players will have opportunities to place desks/tables on their credited segments. Greater fees occur with desks/tables present. Players track losses/gains on a money tracking card. The player with the most amount of money after a set time, or a player who has made all other players forfeit wins the game. A means of playing the present game is also disclosed. | 2011-11-10 |
20110275039 | TEACHING AND TRAINING HEAD MODEL FOR HAIRCUTTING AND HAIRDRESSING - A teaching and training head model for haircutting and hairdressing includes a soft and flexible synthetic resin casing, a shape keeping arrangement mounted in the casing to keep the shape of the casing and a support stand for supporting the shape keeping arrangement. The support stand includes: a base board; and a guiding bar, a pushing cylinder for lifting plates and a pressing cylinder which are centered about the center of the base board and sequentially positioned on the base board from inside to outside. A fixing ring for fixing the casing is provided at the periphery of the pressing cylinder. The shape keeping arrangement includes components fitted with the support stand and umbrella-shaped supporting components for supporting the casing. The shape keeping arrangement has a simple structure, and it will expand to keep the shape of the casing when the shape keeping arrangement mounted in the casing is inserted into the supporting stand. The shape keeping arrangement is simple to assemble. | 2011-11-10 |
20110275040 | MULTIFUNCTIONAL EDUCATIONAL AND ENTERTAINMENT APPARATUS - Aspects describe a multifunctional apparatus that provides both educational and entertainment value. The multifunctional apparatus can be a meal plate that comprises a stationary base unit that contains a motor that rotates a platform on which the meal plate is attached. Stationary base unit can also cause the meal plate to vibrate. Stationary base unit comprises means for producing audio output communication and/or visual signals. Controls can be operated through interaction with stationary base unit and/or a remote control device. The meal plate can be interchangeable, wherein a multitude of meal plates can be utilized with a single stationary base unit. The multifunctional apparatus can utilize technology that can synchronize an object, such as a meal plate, with the base. | 2011-11-10 |
20110275041 | Training apparatus for calf roping - A calf roping training apparatus incorporating a simulated calf, a support column and a towing structure. The support column has a spin joint and an invert joint. The calf body of the simulated calf is formed by one or more pieces of simulated skin and a simulated head fixed in anatomical form by a body frame. The support column is anchored to the towing structure. The towing structure has a tow member, a pair of long skids, a short skid, and a towing attachment device. The support column base is attached to the short skid which provides for transfer of the weight of the simulated calf to the ground. The support column top is attached to or integrated with the body frame. | 2011-11-10 |
20110275042 | Human-motion-training system - Certain embodiments of the present invention are directed to automated human-motion-training systems. These automated human-motion-training systems include a hardware platform that provides for stored-instruction processing and that includes memory, an I/O interface, and an audio-signal generation and output component, and an operating system or control program that executes on the hardware platform and that provides a program-execution environment. The automated human-motion-training systems further include components of the human-motion-training system that provide for automated proctoring of human-motion exercises and training regimes, including monitoring of a user's body position, producing feedback corresponding to a user's body position, and determining a user's performance in order to modify the exercises and training regimes so that they provide optimal-challenge-point-based training over the course of multiple repetitions and training sessions. | 2011-11-10 |
20110275043 | SYSTEMS AND METHODS FOR FACILITATING GAIT TRAINING - In one embodiment a gait training system includes a patient interface adapted to attach to a patient's thigh, the patient interface defining a channel, a cord that passes through the channel of the patient interface, and connecting means attached to a first end of the cord for connecting the cord to the patient's forefoot, wherein pulling of the cord pulls the patient interface forward and upward to emulate hip flexion and simultaneously pulls the connecting means upward to emulate ankle dorsiflexion. | 2011-11-10 |
20110275044 | INTERVAL FITNESS TRAINING - A computer-implemented method and/or computer program product for developing a physical fitness regimen, including establishing individualized physical fitness parameters based upon individualized information; obtaining physical fitness data from one or more computer database sources; developing a physical fitness regimen based upon the individualized information and the physical fitness data. | 2011-11-10 |
20110275045 | Video Overlay Sports Motion Analysis - Methods and system for providing a video overlay sports motion analysis. An embodiment method comprises receiving files containing video frames recording a professional athlete's performance of a motion and video frames of a student's performance of the motion. A stick figure representation of the professional athlete's motion is provided as a video sequence, and the video sequence is aligned to, and overlaid with, outlines of the student athlete. A playable video file providing a visual comparison between the student athlete's motion and the motion of the professional is created and delivered. Differences between the two motions are ascertained. A representation of the student performing the motion correctly is created and stored to enable playback; enabling the student to mentally visualize himself/herself performing the correct motion. The embodiments provide a turnkey system usable from anywhere worldwide by any student or coach at low cost. | 2011-11-10 |
20110275046 | METHOD AND SYSTEM FOR EVALUATING CONTENT - The present disclosure describes methods, systems, and techniques for evaluating content, such as audio and video content. The content is presented to a respondent for evaluation. Feedback is collected from the respondent using a feedback collection device that presents different kinds of reactions to the respondent for selection during presentation of the content. Feedback is collected using a collection server and stored in a collection database. The feedback can be analyzed and summarized in a report to a pollster. Beneficially, the described methods, systems, and techniques allow for real-time collection of multiple respondent reactions, which facilitates accurate, efficient, and quick evaluation of the content. | 2011-11-10 |
20110275047 | Seeking Answers to Questions - A computer-implemented method of seeking answers to questions comprises receiving one or more questions from users seeking answers, maintaining an inventory of pending questions to be answered, and transmitting a question from the pending question inventory to a network location determined to be topically relevant to the transmitted question based on the content of the network location. | 2011-11-10 |
20110275048 | Educational system and method for testing memorization - The educational system for testing memorization provides a computerized classroom system for testing a student's memorization of a text to be recited, for example, the text of the Qur'an. A set of digital data representing a text of a written work to be memorized by a student, such as the text of the Qur'an, is recorded in a database. Upon selection of a text portion to be tested, the portion is divided into individual words, and the user recites the portion, with the audio input being received and recorded by the system. The audio input from the user is converted into textual data, which is compared with a corresponding word of the portion stored in the database. If the spoken word matches the corresponding word portion stored in the database, the word is instantly displayed on a computer display, and the user may then speak the next word. | 2011-11-10 |
20110275049 | System and method for pre-selection in computer adaptive tests - A system and method for administering tests at a computer terminal in communication with a remote location is provided. The method includes: establishing an initial threshold amount of questions, the initial threshold amount being a positive integer greater than one; sending to the computer terminal a first batch of questions that exceeds the threshold amount, the batch of questions having a substantially equal difficulty level; receiving an answer to one of the batch of questions; selecting, based on the answer to the one of the number of questions, a new question having a difficultly level different than the one of the number of questions; and sending the new question to the computer terminal. | 2011-11-10 |
20110275050 | ELECTRONIC FLASHCARDS - A method, computer-readable medium and system for implementing electronic flashcards are disclosed. Data operable to display a first set of information in a first region of a graphical user interface is generated, wherein the data is further operable to cause a display of the first set of information while a second set of information is not displayed, and wherein the first and second sets of information are associated with a first electronic flashcard. Data operable to display the second set of information in a second region of the graphical user interface is generated, wherein the data is further operable to cause a display of the second set of information responsive to a request to display the second set of information. Data operable to display a second electronic flashcard in a third region of the graphical user interface is generated. | 2011-11-10 |
20110275051 | APPARATUS AND METHOD FOR RECOGNITION OF PATIENT ACTIVITIES WHEN OBTAINING PROTOCOL ADHERENCE DATA - A medication confirmation method and apparatus. The method of an embodiment of the invention includes the steps of capturing one or more video sequences of a user administering medication, storing the captured one or more video sequences, and comparing at least one of the stored video sequences with a corresponding one or more prerecorded video sequences to confirm that the user has properly administered the medication. | 2011-11-10 |
20110275053 | ALCOHOL PRODUCTION PROCESS - The invention relates to the production of products such as alcohols and acids by microbial fermentation, particularly microbial fermentation of substrates comprising CO. It more particularly relates to methods and systems for improving efficiency of products by microbial fermentation. In particular embodiments, the invention provides a method of optimising production of desired products including the step of ascertaining the proportion of CO converted to CO2. | 2011-11-10 |
20110275054 | ENHANCED ANIMAL CELL GROWTH USING ULTRASOUND - A method of increasing the rate of growth of an animal cell or cell culture include the use of ultrasound at a frequency greater than about 1 MHz. | 2011-11-10 |
20110275055 | THERMAL UNIFORMITY FOR THERMAL CYCLER INSTRUMENTATION USING DYNAMIC CONTROL - A method for performing polymerase chain reactions (PCR) for improving thermal non-uniformity is provided. The method includes measuring a first temperature, by a first sensor, of a first sample block sector of a sample block and measuring a second temperature, by a second sensor, of a second sample block sector of the sample block that is adjacent to the first sample block sector. The method further includes calculating, by a thermoelectric controller, a difference in temperature between the first temperature and the second temperature and adjusting, by the thermoelectric controller, the first temperature of the first sample block sector based on the difference in temperature by using one or more thermoelectric coolers. The one or more thermoelectric coolers is configured to heat or cool the first sample block sector by adjusting power output from the thermoelectric controller. | 2011-11-10 |
20110275056 | Method and Apparatus for Controlling a Cell Expansion Apparatus - A method for controlling cell expansion comprising conducting a fluid containing cellular matter into a cellular growth area; providing oxygenated fluid to said cellular growth area to maintain conditions conducive for cell growth in said cellular growth area; monitoring inflow and outflow conditions; determining rates of change (first derivative) for selected conditions and calculating cell numbers therefrom; determining a rate of change of a rate of change (second derivative) for the selected conditions and calculating a predicted process time; and terminating the growth process when adequate cell numbers have been produced and an apparatus for performing the method. | 2011-11-10 |
20110275057 | ALLOSTERIC CONTROL OF PROTEINS BY MANIPULATING MECHANICAL TENSION - A method of altering the conformation of a polypeptide having a known three-dimensional structure is described. The method comprises attaching a first end of a polymer to a first portion of the polypeptide, attaching a second end of the polymer to a second portion of the polypeptide, and altering the mechanical tension of the polymer, thereby altering the conformation of the polypeptide. The alteration of the conformation of the polypeptide may increase or decrease the binding affinity of the polypeptide for a substrate bound by the polypeptide, or alter the catalytic rate of an enzyme. Typically, the polymer is a polynucleotide or polypeptide. | 2011-11-10 |
20110275058 | SELF-CONTAINED BIOLOGICAL ASSAY APPARATUS, METHODS, AND APPLICATIONS - A self-contained, fully automated, biological assay-performing apparatus includes a housing; a dispensing platform including a controllably-movable reagent dispensing system, disposed in the housing; a reagent supply component disposed in the housing; a pneumatic manifold removably disposed in the housing in a space shared by the dispensing platform, removably coupled to a fluidic transport layer and a plurality of reservoirs, wherein the fluidic transport layer, the reservoirs, and a test sample to be introduced therein are disposed in the housing in the space separate from the dispensing platform; a pneumatic supply system removably coupled to the pneumatic manifold in the housing in a space separate from the dispensing platform; and a control system coupled to at least one of the dispensing platform and the pneumatic supply system, disposed in the housing. | 2011-11-10 |
20110275059 | Diagnostic Transcript and Splice Patterns of HR-HPV in Different Cervical Lesions - The present invention relates to a method for differentiating in a subject with HR-HPV between a severe form of HR-HPV infection and a mild form of HR-HPV infection. It further is concerned with a composition comprising a probe oligonucleotide mixture, a device, and a kit for use in conjunction with the method of the invention. | 2011-11-10 |
20110275060 | DIAGNOSING AND MONITORING INFLAMMATORY DISEASES BY MEASURING COMPLEMENT COMPONENTS ON WHITE BLOOD CELLS - The invention is related to methods of diagnosing inflammatory diseases or conditions by determining levels of components of the complement pathway on the surface of white blood cells. | 2011-11-10 |
20110275061 | ASSAYS USING SURFACE-ENHANCED RAMAN SPECTROSCOPY (SERS)-ACTIVE PARTICLES - Disclosed herein are diagnostic assays using surface enhanced Raman spectroscopy (SERS)-active particles, including liquid-based assays; magnetic capture assays; microparticle-nanoparticle satellite structures for signal amplification in an assay; composite SERS-active particles useful for enhanced detection of targets; and sample tubes and processes for using the same. | 2011-11-10 |
20110275062 | Systems And Methods For Integrating A Single DNA Molecule Into A Molecular Electronic Device - The disclosed subject matter provides a techniques for precisely and/or functionally cutting carbon nanotubes, e.g., single walled carbon nanotubes (“SWNTs”) and integrating a single nucleic acid molecule (e.g., a DNA molecule) into a gap formed into the carbon nanotubes. In one aspect, a method of fabricating a molecular electronic device includes disposing a SWNT on a base layer, forming a gap in the SWNT using a lithographic process, and disposing a single DNA strand across the gap so that each end of the nucleic acid contacts a gap termini. The disclosed subject matter also provides techniques for measuring the electrical properties (charge transport) of a DNA molecule which is integrated into an SWNT. Furthermore, a molecular electronic device including an SWNT with an integrated nucleic acid molecule is disclosed. | 2011-11-10 |
20110275063 | SYSTEMS AND METHODS OF DROPLET-BASED SELECTION - The present invention generally relates to fluidic droplets, and techniques for screening or sorting such fluidic droplets. In some embodiments, the fluidic droplets may contain cells (e.g., hybridoma cells) that can secrete various species, such as antibodies, for example. In one aspect, a plurality of fluidic droplets containing cells is screened to determine proteins, antibodies, polypeptides, peptides, nucleic acids, or the like. For example, cells able to secrete species such as antibodies may be se according to certain embodiments of the invention. Examples of such cells include, for instance, immortal cells such as hybridomas, or non-immortal cells such as B-cells. For instance, blood cells may be encapsulated within a plurality of fluidic droplets, and the cells able to produce antibodies may be determined. In some cases, expression or secretion levels may be determined using signaling entities, for example, determinable microparticles present within the fluidic droplet. Other aspects of the invention relate to kits involving such fluidic droplets, methods of promoting the making or use of such fluidic droplets, and the like. | 2011-11-10 |
20110275064 | METHOD FOR HEMATOLOGY ANALYSIS - A method whereby one or more fluorescent dyes are used to bind and stain nucleic acids in certain blood cells, such as, for example, white blood cells, nucleated red blood cells, and reticulocytes, and to induce fluorescent emissions upon excitation of photons from a given source of light, such as, for example, a laser, at an appropriate wavelength. More particularly, this invention provides a method whereby a fluorescent trigger is used in a data collection step for collecting events that emit strong fluorescence, in order to separate white blood cells and nucleated red blood cells from red blood cells and platelets without the need for using a lysing agent. | 2011-11-10 |
20110275065 | METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF THYROID CANCER - Methods for detecting thyroid cancer or thyroid cancer status in a subject are described comprising measuring novel markers or polynucleotides encoding the markers in a sample from the subject. The invention also provides localization or imaging methods for thyroid cancer, and kits for carrying out the methods of the invention. The invention also contemplates therapeutic applications for thyroid cancer employing the novel markers, polynucleotides encoding the markers, and/or binding agents for the markers. | 2011-11-10 |
20110275066 | METHOD OF DNA ANALYSIS USING MICRO/NANOCHANNEL - Methods are provided for tagging, characterizing and sorting double-stranded biomolecules while maintaining the integrity of the biomolecules. | 2011-11-10 |
20110275067 | ANALYSIS OF CHEMICALLY CROSSLINKED CELLULAR SAMPLES - A method of analyzing cellular samples that include a chemically crosslinked analyte is provided. The analysis typically involves the use of mass spectrometry. | 2011-11-10 |
20110275068 | METHOD - The present invention relates to a combination method for A) measuring the copy number frequency of one or more nucleic acid sequences in a sample; and B) analysing the sequence of at least part of the nucleic acid sequence(s), wherein method A) comprises the steps of:
| 2011-11-10 |
20110275069 | Method for the detection of gene transcripts in blood and uses thereof - The present invention is directed to detection and measurement of gene transcripts ad their equivalent nucleic acid products in blood. Specifically provided is analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using gene-specific and/or tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-specific genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen. | 2011-11-10 |
20110275070 | HYBRIDIZATION AND MISMATCH DISCRIMINATION USING OLIGONUCLEOTIDES CONJUGATED TO MINOR GROOVE BINDERS - Conjugates between a minor groove binding molecule, such as the trimer of 1,2-dihydro-(3H)-pyrrolo[3,2- | 2011-11-10 |
20110275071 | Methods and Reagents for Combined PCR Amplification - An oligonucleotide probe is disclosed, the probe including an oligonucleotide, a fluorescer molecule attached to a first end of the oligonucleotide and a quencher molecule attached to the opposite end of the oligonucleotide. The probe is rendered impervious to digestion by the 5′→3′ exonuclease activity of a polymerase and the 5′→3′ extension of by a polymerase. The invention also includes methods for performing combined PCR amplification and hybridization probing, one such method including the steps of contacting a target nucleic acid sequence with PCR reagents and an oligonucleotide probe as described above, and subjecting these reagents to thermal cycling. One preferred refinement of the above method further includes the addition of a strand displacer to facilitate amplification. Additional similar combined PCR hybridization methods are disclosed, such methods not requiring probes having their 5′ ends protected, wherein (i) the polymerase lacks 5′→3′ exonuclease activity, (ii) a 5′→3′ exonuclease inhibitor is included, and (iii) an exonuclease deactivation step is performed. | 2011-11-10 |
20110275072 | EGFR MUTATIONS - The present invention relates to mutations in Epidermal Growth Factor Receptor (EGFR) and methods of detecting such mutations as well as prognostic methods method for identifying a tumors that are susceptible to anticancer therapy such as chemotherapy and/or kinase inhibitor treatment. The methods involve determining the presence of a mutated EGFR gene or mutated EGFR protein in a tumor sample whereby the presence of a mutated EGFR gene or protein indicates the tumor is susceptible to treatment. | 2011-11-10 |
20110275073 | Method for detecting tumor-associated DNA in blood or blood fractions - This invention relates to detection of specific extracellular nucleic acid in plasma or serum fractions of human or animal blood associated with neoplastic or proliferative disease. Specifically, the invention relates to detection of nucleic acid derived from mutant oncogenes or other tumor-associated DNA, and to those methods of detecting and monitoring extracellular mutant oncogenes or tumor-associated DNA found in the plasma or serum fraction of blood by using rapid DNA extraction followed by nucleic acid amplification with or without enrichment for mutant DNA. In particular, the invention relates to the detection, identification, or monitoring of the existence, progression or clinical status of benign, premalignant, or malignant neoplasms in humans or other animals that contain a mutation that is associated with the neoplasm through detection of the mutated nucleic acid of the neoplasm in plasma or serum fractions. The invention permits the detection of extracellular, tumor-associated nucleic acid in the serum or plasma of humans or other animals recognized as having a neoplastic or proliferative disease or in individuals without any prior history or diagnosis of neoplastic or proliferative disease. The invention provides the ability to detect extracellular nucleic acid derived from genetic sequences known to be associated with neoplasia, such as oncogenes, as well as genetic sequences previously unrecognized as being associated with neoplastic or proliferative disease. The invention thereby provides methods for early identification of colorectal, pancreatic, lung, breast, bladder, ovarian, lymphoma and all other malignancies carrying tumor-related mutations of DNA and methods for monitoring cancer and other neoplastic disorders in humans and other animals. | 2011-11-10 |
20110275074 | METHOD AND APPARATUS FOR CHROMOSOME PROFILING - A method and apparatus for generating an Interphase chromosome profile. The method comprises obtaining a sample containing cells having chromosomes for profiling; obtaining species specific DNA probes, wherein the DNA probes are capable of marking at least one chromosome at substantially equidistant locations on said chromosome; hybridizing the sample with the DNA probes with plurality of fluorescent labels; and using visual analysis for determining the profile of the chromosome. | 2011-11-10 |
20110275075 | SOX MODULATORS IN THE TREATMENT OF ALOPECIA - An in vitro method for screening candidate compounds for the preventive or curative treatment of alopecia is described. The method can include determining the capacity of a compound to modulate the expression or the activity of a SOX transcription factor. The use of modulators of the expression or the activity of the transcription factor for the treatment of alopecia is also described. Methods for the in vitro diagnosis or prognosis of the pathology are also described herein. | 2011-11-10 |
20110275076 | BULKED MUTANT ANALYSIS (BMA) - The current invention relates to a new strategy for identification, and optional isolation, of a nucleic acid sequence that is expressed in an organism and that is related to a particular phenotype (trait of a character) of said organism. With the method of the current invention it has become possible to, in contrast to known methods in the art, efficiently identify, isolate or clone genes in, for example, organism like (crop) plants for which no or only limited information with respect to the genome is available. | 2011-11-10 |
20110275077 | Oligonucleotide-Coated Affinity Membranes and Uses Thereof - A method of analyzing tissue sections in a manner that provides information about the presence and expression levels of multiple biomarkers at each location within the tissue section. The method comprises the preparation of membranes having covalently bound oligonucleotides and the use of those membranes for evaluation of various markers in the sample. The membranes may be arranged in stacks, wherein each layer has a different oligonucleotide capture strand. Transfer oligonucleotides complementary to the capture strands are attached through a cleavable bond to antibodies that recognize and bind to specific biomarkers present in the tissue sample. The tissue sample is exposed to the antibody-transfer strand conjugate and then treated with a cleaving reagent. Upon cleavage, the transfer strand migrates through the stack and binds to the capture strand. The level of expression of the biomarker may be determined by measuring expression of a reporter on the transfer strand. | 2011-11-10 |
20110275078 | RNA-Containing Microvesicles and Methods Thereof - Contemplated compositions and methods are directed to the use of microvesicles from an optionally recombinant donor cell to impart a desirable effect to a recipient cell. In certain preferred aspects, RNA of the microvesicles is employed to achieve the desirable effect. For example, microvesicles are used in vitro to increase the number of passages of a cell growing in a medium, reduce serum and/or growth factor requirements of a cell growing in a medium, and/or delay differentiation of a cell growing in a medium. Further preferred aspects include use of the microvesicles as therapeutic agents in which RNA, a membrane protein, and/or a cytosolic protein encapsulated in or coupled to the microvesicle provide a therapeutic effect. Additionally, diagnostic methods are contemplated in which RNA of a microvesicle isolated from a mammal is associated with a condition of the mammal. | 2011-11-10 |
20110275079 | DIAGNOSTIC BIOMARKERS OF DIABETES - Methods are disclosed for the identification of gene sets that are differentially expressed in PBMCs of patients diagnosed with a pre-diabetic disease state and overt type II diabetes. 3 gene and 10 gene signatures are shown to accurately predict a diabetic disease state in a patient. The application also described kits for the rapid diagnosis of diabetic disease states in patients at a point of care facility. | 2011-11-10 |
20110275080 | PROTEOGLYCAN SPLICE VARIANTS AS THERAPEUTICS AND DIAGNOSTICS FOR AMYLOID DISEASES - The identification of novel Syndecan-2 splice variants and their use in the diagnosis and therapeutic intervention of Alzheimer's disease and other amyloid diseases. In addition the use of new animal models expressing or devoid of syndecan-2 splice variants to effectively screen and identify potential therapeutic compounds for Alzheimer's disease. | 2011-11-10 |
20110275081 | BIOMARKER FOR DIAGNOSIS OF CANINE CANCER - The present invention is related to a biomarker for diagnosis of canine cancer, wherein the biomarker is KMO (kynureinie 3-monooxygenase) gene, and the canine cancers including CTVT (canine transmissible venereal tumor) and MGT (mammary gland tumor). The expression level of KMO gene in canine malignant tumor tissues is up-regulated as compared with benign tissues. Furthermore, the expression level of KMO gene in malignant tumor tissue is higher than in the non-metastasis tumor tissue. By detection of the expression level of the present invention biomarker in suspecting tissue specimen, malignancy of tumor tissues can be determined correctly and rapidly. | 2011-11-10 |
20110275082 | GENES INVOLVED IN ESTROGEN METABOLISM - The invention concerns genes that have been identified as being involved in estrogen metabolism, and are useful as diagnostic, prognostic and/or predictive markers in cancer. In particular, the invention concerns genes the tumor expression levels of which are useful in the diagnosis of cancers associated with estrogen metabolism, and/or in the prognosis of clinical outcome and/or prediction of drug response of such cancers. | 2011-11-10 |
20110275083 | GENES INVOLVED IN ESTROGEN METABOLISM - The invention concerns genes that have been identified as being involved in estrogen metabolism, and are useful as diagnostic, prognostic and/or predictive markers in cancer. In particular, the invention concerns genes the tumor expression levels of which are useful in the diagnosis of cancers associated with estrogen metabolism, and/or in the prognosis of clinical outcome and/or prediction of drug response of such cancers. | 2011-11-10 |
20110275084 | METHODS OF DETERMINING SUSCEPTIBILITY OF TUMORS TO TYROSINE KINASE INHIBITORS - This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly FGFR2 variants, which are linked to drug resistance. The disclosure further provides methods of diagnosis and theranosis, and development of new therapeutic agents using these molecules and fragments thereof, and kits for employing these methods and compositions. | 2011-11-10 |
20110275085 | METHOD FOR DETECTION OF AUTOIMMUNE DISEASES - The present invention relates to the field of diagnostics, especially to the detection of autoimmune diseases such as rheumatoid arthritis. Particularly, the invention provides a method for detecting the presence or absence of rheumatoid arthritis, or of a predisposition therefore or for monitoring rheumatoid arthritis in a subject using expression data of target genes related to immune system and tools of bioinformatics. | 2011-11-10 |
20110275086 | NEGATIVE CORRELATION BETWEEN IRP-2 AND TRANSFERRIN RECEPTOR EXPRESSION AS A DIAGNOSTIC OF ALZHEIMER'S DISEASE - A method of diagnosing Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) is disclosed which was identified by the fact that an increased level of iron regulating protein-2 (IRP-2) was identified in Alzheimer's patients. Further, diseases of increased cellular metabolism such as cancer showed high levels of both IRP-2 and transferrin receptor. This suggests that, in diseases of increased cellular metabolism, both aspects of iron accumulation are highly expressed, while in Alzheimer's disease only IRP-2 is highly expressed. From these results, a non-invasive test for Alzheimer's disease may be produced using patient samples containing peripheral blood cells and identifying the level of expression of IRP-2 and Transferrin receptor. Those patients which: 1. over-express IRP-2 as compared with normal controls, and 2. have comparable levels of Transferrin receptor expression to normal controls, can be identified as having or prone to AD and MCI. Further, it can be envisioned that this may be used for further diagnosis and staging of cancers of the blood. | 2011-11-10 |
20110275087 | INSTRUMENTS AND METHODS FOR MIXING THE CONTENTS OF A DETECTION CHAMBER - A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle. | 2011-11-10 |
20110275088 | USE OF EEF1A AS BIOMARKER AND A METHOD OF SCREENING METAP2 INHIBITORS - The invention relates to a method for screening compounds, which inhibit MetAP2 activity, by providing a cellular system or a sample thereof being capable of expressing MetAP2 and/or EEF1A, incubating at least a portion of the system with compounds to be screened, and detecting MetAP2 inhibition by determining EEF1A with N-terminal methionine residue (MetEEF1A). Another object of the invention concerns a method for monitoring physiological and/or pathological conditions, which are caused, mediated and/or propagated by MetAP2 activity, by administering an effective amount of at least a single compound to a mammal in need of such treatment and determining MetEEF1A in a biological sample withdrawn from the mammal. The invention also relates to the use of EEF1A as biomarker. | 2011-11-10 |
20110275089 | Methods for predicting survival in metastatic melanoma patients - Cellular and genetic signatures and methods of using same for subcategorizing stage III melanoma tumors are described herein. The signatures and methods are particularly useful with regard to establishing more distinct criteria on which basis to differentiate stage IIIB and IIIC melanoma patients. Assessment of the cellular and genetic signatures of a melanoma sample using methods described herein yields information on which basis differential survival duration and sensitivity to various cancer therapies can be predicted for a Stage IIIB or Stage IIIC melanoma patients. As described herein, gene expression profiling, determination of mitotic index (MI), and quantification of tumor infiltrating leukocytes (TILs) and CD3+ cells in metastatic lesions may be utilized to predict or assess drug response, drug sensitivity, and clinical outcome in metastatic melanoma patients. | 2011-11-10 |
20110275090 | USE OF ACHROMOPEPTIDASE FOR LYSIS AT ROOM TEMPERATURE - A process for detecting the presence or absence of gram-positive bacteria in a biological sample. The biological sample can be obtained from any mammal and contains, at a minimum, cellular components. The sample is combined with an enzymatic lysing agent such as achromopeptidase, and lysed at room temperature. Ferric oxide is then added to the sample containing achromopeptidase. A magnetic field is applied to the sample and nucleic acids are extracted from the cellular components. Target nucleic acids, if present, are amplified using techniques such as Polymerase Chain Reaction (PCR) and then used to detect the presence or absence of gram-positive bacteria. | 2011-11-10 |
20110275091 | USE OF PRECURSORS OF TACHYKININS AND/OR THEIR FRAGMENTS IN MEDICAL DIAGNOSTIC - The present invention relates to the use of protachykinin and/or fragments thereof that can be isolated from body fluids, tissues or other bioiological samples and therefore, serves as a marker peptide for medical diagnosis of diseases/disorders of the central nervous system, including Alzheimer's disease, Parkinson's disease, depression and/or conditions of pain, neurological, endocrinological, cerebral, muscular, local, systemic, chronic, inflammatory diseases, infectious diseases comprising bacterial and viral infections, meningitis, sepsis, Crohn's disease, colitis ulcerosa, sickle cell anemia, ischemia, amyotrophic lateral sclerosis, arthritis comprising rheumatoid arthritis, bronchitis, hyperalgesia, asthma, intoxication comprising bacterial intoxication, immunological disorders, poly/-trauma comprising cranio-cerebral trauma, tumors/cancer, stroke, stress, atopis dermatitis, HIV, Huntington's disease, burns, schizophrenia, Hirschsprung's disease, allergies, familial dysautononmia (Riley Day syndrome), hematopoietic disorders, gliomas comprising glioblastomas and astrocytomas, disorders of the blood brain barrier. The invention further provides antibodies for binding to certain proteins and their fragments, more specifically protachykinin and protachykinin peptides. In accordance with the invention, a kit useful for the above-mentioned diagnosis is also provided. | 2011-11-10 |
20110275092 | METHOD FOR DETECTING BIOLOGICAL MARKERS BY AN ATOMIC FORCE MICROSCOPE - A method for detecting biological markers involves preparing sample slices using a hard granular labeling material such as hard nano-gold granular material. The sample slices are fixed to sample patches. The sample is scanned using the atomic force microscope (AFM) in tapping mode to collect the height, amplitude and phase data of the hard granular material. The hard labeling material is mainly determined through changes in discrepancies in phase diagram color, while height and amplitude diagrams are used to provide auxiliary evidence of sample morphological features. Integrating these data with the state of the biological target object can thus determine the existence of a marked object. | 2011-11-10 |
20110275093 | NOVEL USE OF ADENOVIRUSES AND NUCLEIC ACIDS THAT CODE FOR SAID VIRUSES - The present invention is related to the use of a virus, preferably an adenovirus, for the manufacture of a medicament, whereby the virus is replication deficient in cells which do not have YB-1 in the nucleus, and the virus codes for an oncogene or oncogene product, in particular an oncogene protein, which transactivates at least one viral gene, preferably an adenoviral gene, whereby the gene is selected from the group comprising E1B55kDa, E4orf6, E4orf3 and E3ADP. | 2011-11-10 |
20110275094 | PHOSPHORYLATED FMS-RELATED TYROSINE KINASE 3 BIOMARKER ASSAY - Provided herein are methods for detecting the presence of human pFLT3 in a sample. An exemplary assay provided herein is an ELISA method (e.g., sandwich ELISA). Also provided herein are methods for detecting FLT3 phosphorylation in a sample, diagnosing a patient having a FLT3-activating mutation, identifying a compound that activates or is otherwise and agonist of human FLT3 phosphorylation, identifying a compound that inhibits or is otherwise an antagonist of human FLT3 phosphorylation, determining the efficacy of a compound for increasing, decreasing or otherwise modulating human FLT3 phosphorylation in a patient. Further provided are kits for carrying out the said methods. Such kits comprise at least a total FLT3 antibody optionally immobilized on a solid support and a labeled pFLT3 antibody. | 2011-11-10 |
20110275095 | Microarrays for Allergen-Specific IgE - Biological samples are assayed for the presence of IgE antibodies specific to unknown allergens in the samples. Known allergens conjugated to biotin are attached as an array of spots on a streptavidin-linked membrane. A sample is incubated with the membrane containing attached known allergens. After washing away excess sample, the membrane is contacted with a labeled anti-IgE, e.g. alkaline phosphatase-labeled anti-IgE, thus attaching anti-IgE to the IgE from the sample, now bound to known allergens. The excess labeled anti-IgE is washed away and the attached IgE remaining on the membrane identified by adding a substrate for the label, thus producing a measurable response. | 2011-11-10 |
20110275096 | Detection of Activation of Endothelial Cells as Surrogate Marker for Angiogenesis - Methods, compositions and kits are provided for assessing angiogenesis through sensitive, direct detection of activation of endothelial cells at molecular levels. In general, activation of endothelial cells is detected by measuring the levels of cellular components and their protein complexes participating in a specific angiogenesis signaling pathway in endothelial cells. The methods can be used for assessing status of diseases associated with undesirable angiogenesis, such as the likelihood of developing the disease, presence or absence of the disease, prognosis of the disease and the likelihood of response or resistance to a particular anti-angiogenic therapy. The methods can also be used to guide the design of effective therapeutic regimens targeting a specific angiogenic signaling pathway, as well as in conjunction with therapeutic intervention of diseases or conditions associated with undesirable angiogenesis. | 2011-11-10 |
20110275097 | DRUG SELECTION FOR LUNG CANCER THERAPY USING ANTIBODY-BASED ARRAYS - The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments. | 2011-11-10 |
20110275098 | Method for Evaluating The Immunogenicity of Proteins - The invention relates to a method for evaluating the immunogenicity of proteins in humans or animals, comprising analysing the CD4+ T lymphocyte response specific to the protein to be tested in individuals of the (human or animal) species in which the immunogenicity of said cell is analysed. | 2011-11-10 |
20110275099 | DIAGNOSTIC METHOD FOR DISEASES BY SCREENING FOR HEPCIDIN IN HUMAN OR ANIMAL TISSUES, BLOOD OR BODY FLUIDS AND THERAPEUTIC USES THEREFOR - The present invention concerns methods and kits for diagnosing a disease condition characterized by non-physiological levels of hepcidin protein, including prohepcidin and fragments thereof, comprising obtaining a tissue or fluid sample from a subject; contacting the sample with an antibody or fragment thereof that specifically binds to a polypeptide corresponding to the amino acid sequence between and including amino acids 25 and 49 of a hepcidin precursor protein, and quantifying the hepcidin precursor level using an assay based on binding of the antibody and the polypeptide; wherein the non-physiological level of prohepcidin is indicative of the disease condition. The present invention also concerns diagnostic methods and kits for applications in genetic technological approaches, such as for overexpressing or downregulating hepcidin. | 2011-11-10 |
20110275100 | SERPIN B 13 AS A MARKER FOR SQUAMOUS CELL CARCINOMA OF THE LUNG - Disclosed is a method aiding in the assessment of squamous cell carcinoma (SCC). It involves the use of the protein serpin B13 as a marker of SCC. Furthermore, the disclosure relates to a method for assessing lung cancer in a tissue sample derived from a patient having non-small cell lung carcinoma (NSCLC) and for differentiating SCC from adenocarcinoma or large cell carcinoma of the lung. | 2011-11-10 |
20110275101 | METHOD FOR USING DIVISION ARRESTED CELLS IN SCREENING ASSAYS - Division arrested cells are used in screening assays to determine the effect of a substance of interest on the cells. The division arrested cells can be used in drug screening assays, signal transduction assays, and are especially useful in large scale, high throughput assays. | 2011-11-10 |
20110275102 | ACTIVATION OF MUTATED RAC-PK - The invention concerns RAC-PK and fragments thereof, as well as activators and inhibitors of RAC-PK for use as medicaments, particularly in the treatment of diseases concerned with abnormalities in processes modulated by insulin, such as cellular proliferation, insulin deficiency and/or excess blood sugar levels. Moreover, the invention provides RAC-PK for use in screening potential mimics or modulators thereof. A method for screening for agents capable of affecting the activity of GSK3 is also disclosed. The invention further provides a screening kit comprising the RAC-PK as an active principle, and a method for screening compounds which are candidate mimics or modulators of RAC-PK activity comprising detecting specific interactions between the candidate compounds and RAC-PK. There is also provided a process for activating RAC-PK comprising treatment thereof with a phosphatase inhibitor. | 2011-11-10 |
20110275103 | EMISSION RATIOMETRIC REPORTERS OF MEMBRANE PDK1 ACTIVATION - Phosphoinositide-dependent kinase 1 (PDK1) activity reporters can be used in high throughput assays for drug screening. | 2011-11-10 |
20110275104 | Device and Method for Detection of Humidity-Compromised Urine Test Strips - The timing of the reaction of moisture-sensitive reagents for detecting the presence of analytes, e.g. leukocytes in urine samples, is used to detect when the reagents have been compromised by excess humidity. The ratio of light reflectance at wavelengths characteristic of the products of reaction between the reagents and the analyte and an infra-red reference dye is measured at two preset times after a urine sample has been applied to a test strip and used to determine whether the reagents have been compromised by excessive humidity. The presence of unusually dark samples is determined from the reflected light at 470 and 625 nm in order to confirm that the test strips are humidity-compromised. | 2011-11-10 |
20110275105 | Methods of inducing pluripotency - Methods are provided for inducing non-pluripotent cells to become pluripotent. Methods also include identifying and isolating induced pluripotent (iPS) cells and uses thereof. Compositions and kits for carrying out the subject methods are also provided. | 2011-11-10 |
20110275106 | DEVICE FOR MEASURING ACTIVITY OF CULTURED CELLS, MICROCHAMBER AND METHOD OF MEASURING ACTIVITY OF CULTURED CELLS - A device for measuring activity of cultured cells includes a position detecting unit specifying a position of a cell to be measured, a microchamber controlling unit disposing in the culture container a microchamber which surrounds the cell and forms a measurement space, the measurement space being minute with respect to a volume of the culture container, and a measuring unit measuring environmental factors contained in the measurement space. | 2011-11-10 |
20110275107 | LONG WAVELENGTH ENGINEERED FLUORESCENT PROTEINS - Engineered fluorescent proteins, nucleic acids encoding them and methods of use. | 2011-11-10 |
20110275108 | METHOD FOR RELEASING REDUCING GLYCAN BY AMMONIUM SALT - An objective of the present invention is to provide a glycan releasing method which can be applied to construction of a system for automation of glycan analysis, and particularly a glycan releasing method capable of analyzing an O-linked glycan. The objective could be achieved as a result of finding that the pH is lowered by using an ammonium salt or ammonium ion in the absence of concentrated aqueous ammonia, not using concentrated aqueous ammonia, thus drastically avoiding an undesired side reaction such as a peeling reaction or the like. Therefore, the present invention provides a method of producing an O-linked glycan from a glycan-binding substance having the O-linked glycan, the method includes the steps of (A) bringing an ammonium salt or ammonium ion into contact with the glycan-binding substance in the absence of concentrated aqueous ammonia (for example, under the conditions of the pH of about 7 or higher and lower than about 11); (B) neutralizing the reaction solution obtained in step (A); and (C) collecting the released glycan. | 2011-11-10 |
20110275109 | Immunity Evaluation Method, Apparatus and Program - An immunity evaluation method, apparatus, and program are provided that can evaluate comprehensive immunity with high precision. An immunity evaluation method for evaluating immunity from collected blood includes measuring a number of specific T cells that are CD8 positive and CD28 positive or negative in the collected blood, and determining a T lymphocyte age based on a regression equation on the basis of a correlation between a specific parameter that is dependent on the number of the specific T cells and age, and the number of specific T cells thus measured. | 2011-11-10 |
20110275110 | METHOD FOR ISOLATING OR COUNTING MICROORGANISMS ON AN AGAR CULTURE MEDIUM - The invention relates to a method for isolating microorganisms on an agar culture medium, including the steps of:
| 2011-11-10 |
20110275111 | MICROFLUIDIC DEVICE FOR FULL BLOOD COUNT - The present invention provides a microfluidic device ( | 2011-11-10 |
20110275112 | Microbial growth detector - The disclosure generally relates to a test device that detects microorganism growth by detecting a gas metabolite (e.g., carbon dioxide) produced during the growth of bacteria or other microorganism in a tested sample. The test device can contain a culture growth media separated from a detection area by a gas-permeable membrane. The gas-permeable membrane permits carbon dioxide to permeate into the detection area. The detection area includes a solidified mixture of pH indicators and a gelling agent in the form of a semi-permeable matrix. The optical properties, including the absorbance of light at various wavelengths, of the detection solution change with alterations in carbon dioxide concentration. This test device can then be placed in an incubation and optical detection instrument to monitor changes in optical properties of the detection are induced during microorganism growth in the culture medium. | 2011-11-10 |
20110275113 | MASS SPECTROPHOTOMETRIC DETECTION OF MICROBES - A method of detecting specified target microbes in different types of sample uses only one to two cultivation steps for the enrichment of the target microbes from the sample, preferably in selective culture media, combined with a mass spectrometric detection method that identifies the target microbes in mixtures with other microbes even if the target microbes account for only a small proportion of the mixture. The sample may be a food sample, a sample from bodies of water used for bathing, a soil sample, a swabbed sample, a stool sample, an impactor sample with collected aerosol particles, amongst many others. The detection method is several days faster than standard methods and less expensive. | 2011-11-10 |
20110275114 | METHOD AND MEDIUM FOR DETECTING THE PRESENCE OR ABSENCE OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) IN A TEST SAMPLE - A dry sample analyzing mixture, a liquid sample analyzing medium, and a sample analyzing method, are described for use in detecting the presence or absence of Methicillin Resistant | 2011-11-10 |
20110275115 | METHOD TO DETECT ENDOTHELIAL CELL MASSIVE CALCIUM ACCUMULATION DEATH - Stains that are specific for calcium ion are used to assess and predict the effects of various treatments on the viability of cell types contained in a sample, wherein said stain detects endothelial cells that have massive calcium accumulation death. | 2011-11-10 |
20110275116 | METHODS FOR CONTROL OF FLUX IN METABOLIC PATHWAYS THROUGH ENZYME RELOCATION - Genetically manipulated cells, lysates of such cells, systems, and methods of use thereof are provided, where one or more enzymes in a pathway of interest are genetically modified to incorporate a peptide sequence that provides for relocation of the protein, e.g., to the periplasm, so as to sequester the enzyme, and where the enzyme controls flux in the pathway of interest. | 2011-11-10 |
20110275117 | PHOTOBIOREACTOR SYSTEM WITH HIGH SPECIFIC GROWTH RATE AND LOW DILUTION RATE - Systems and methods for growing photosynthetic cells that may be used to produce a biomass. The systems and methods recycle liquid and can produce a high cell concentration harvested biomass. | 2011-11-10 |
20110275118 | METHOD OF PRODUCING FATTY ACIDS FOR BIOFUEL, BIODIESEL, AND OTHER VALUABLE CHEMICALS - The present invention relates to a method of producing fatty acids, by inoculating a mixture of at least one of cellulose, hemicellulose, and lignin with a microorganism strain and an algae strain, and growing said inoculated strains under successive aerobic-heterotrophic and either anaerobic-phototrophic or anaerobic-heterotrophic conditions creating symbiosis between the strains. Under a first aerobic-heterotrophic condition, the microorganism strain produces extracellulases that hydrolyze cellulose, hemicellulose and lignin, to produce sugars, such as glucose, cellobiose, xylose, mannose, galactose, rhamnose, arabinose or other hemicellulose sugars that are metabolized by the algae strain which also metabolizes acetic acid, glucose and hemicellulose from pretreatment. Then, either under a subsequent anaerobic-heterotrophic condition, the microorganism uses cellulose and produces fermentation products, and the algae strain uses part of the released sugars and exhibits a slower growth rate, or under a further anaerobic-phototrophic condition, the microorganism uses cellulose and produces fermentation products and CO | 2011-11-10 |
20110275119 | METHODS FOR RIBOSOMAL SYNTHESIS OF POLYPEPTIDES CONTAINING UNNATURAL N-TERMINAL GROUPS AND APPLICATIONS THEREOF - The present invention aims to synthesize a polypeptide having an unnatural structure at the N-terminus via a biosynthetic process by translation of amino acid sequence information encoded by a nucleic acid. A polypeptide having any amino acid at the N-terminus is synthesized by using an ARS ribozyme that catalyzes the acylation of tRNA with any amino acid to attach any amino acid to an initiator tRNA, thereby initiating a translation with the initiator tRNA. | 2011-11-10 |