45th week of 2015 patent applcation highlights part 10 |
Patent application number | Title | Published |
20150313984 | IMMUNOGENIC COMPOSITION - The present invention relates to immunogenic compositions comprising a | 2015-11-05 |
20150313985 | IMMUNOGENIC COMPOSITION COMPRISING ELEMENTS OF C. DIFFICILE CDTB AND/OR CDTA PROTEINS - The present invention relates to immunogenic compositions comprising isolated | 2015-11-05 |
20150313986 | PRODUCTION OF HETEROLOGOUS POLYSACCHARIDES IN PLANTS - The invention relates to a novel method for producing bacterial or viral saccharides, such as capsular, immunogenic or membrane saccharides, in a plant cell. Also provided plants, plant cells, plant parts, and plant products comprising such a bacterial or viral saccharide. The invention is based upon the novel finding that bacterial enzymes can be used in a plant cell to produce bacterial or viral capsular, immunogenic and/or membrane saccharides. | 2015-11-05 |
20150313987 | Low Antigen-dose Immunization for Maximizing T-helper Cell 1 (Th1) Immunity Against a Pathogen - Disclosed are compositions, kits, and methods for inducing an immune response against disease. The dosage of antigen contained or utilized in the presently disclosed compositions, kits, and methods is substantially lower than dosages conventionally used in the field. The compositions, kits, and methods may be utilized to induce a cell-mediated response, such as a T-helper cell response, and/or a humoral response against a pathogen or a disease. In some embodiments, the compositions, kits, and methods may be utilized to induce preferentially a Th1 response versus other types of immune responses such as a Th2 response. | 2015-11-05 |
20150313988 | ARTERIVIRUS - The present invention relates to replication-competent Arteriviruses having a decreased DUB/deISGylating activity due to a mutation in the PLP2 domain of the non-structural protein nsp2, to their use as a medicament, their use as a vaccine and in prophylaxis, to vaccines comprising such Arteriviruses and to Arteriviral PLP2-ubiquitin complexes. | 2015-11-05 |
20150313989 | Immunogenic Influenza Composition - Novel compositions useful as influenza immunogens are provided. The compositions enable a host response to immunogen sites normally not recognized by a host. | 2015-11-05 |
20150313990 | HIV THERAPEUTICS AND METHODS OF MAKING AND USING SAME - HIV neutralizing peptides, sulfated HIV-1 envelope proteins and immunogenic fragments thereof are disclosed, as well as nucleic acids encoding these molecules and methods of producing these peptides, envelope proteins and fragments. Methods are also provided for the treatment or prevention of a human immunodeficiency type 1 (HIV-1) infection. The methods can include administering to a subject an HIV neutralizing peptide, sulfated HIV-1 envelope protein or immunogenic fragment thereof as disclosed herein. In several embodiments, administering the HIV neutralizing peptide, sulfated HIV-1 envelope protein or immunogenic fragment generates an immune response in a subject. | 2015-11-05 |
20150313991 | VACCINATION ADJUVANT, PREPARATION AND VACCINES CONTAINING THE SAME - The invention relates to the composition, preparation and use of a formulation as an adjuvant for human or animal use, said formulation comprising at least one bile acid or salts thereof and saponin, in order to enhance the immune response against an antigen, which may or may not be well defined, including but not limited to bacterins, antigens and antigenic preparations that are viral, bacterial or parasitic, and antigens associated with diseases such as different types of cancer. The antigens used can be isolated from pathogens, as well as products resulting from enzymatic or chemical modification, synthetic or recombinant antigens, or mixtures of the same. | 2015-11-05 |
20150313992 | HOST CELLS WITH ARTIFICIAL ENDOSYMBIONTS - The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell through at least five cell divisions, and methods of introducing such single-celled organisms into eukaryotic cells. The invention also provides methods of using such eukaryotic cells. The invention further provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetotactic bacteria. | 2015-11-05 |
20150313993 | Ultrasonic Method and Device for Cosmetic Applications - A combination of low frequency high amplitude sonic frequency vibrations and high frequency low intensity ultrasonic pressure waves are applied to cosmetic compounds and to the skin to promote improved penetration of the cosmetic compounds into the epidermis. The cosmetic applicator device includes means for generating both sonic frequency vibrations and ultrasonic pressure waves adopted to deliver cosmetic compounds into the epidermis safely without significant temperature rise in the skin. Various removable applicator and skin cleaning attachments are also disclosed. | 2015-11-05 |
20150313994 | SURFACE-MODIFIED IRON OXIDE PARTICLES FOR CANCER ABLATION - An object of the present invention is to provide surface-modified ferromagnetic iron oxide particles suitable for electromagnetic-induction cancer ablation, which have excellent heat generation properties and also have excellent dispersion stability in a medium for injection. The surface-modified iron oxide particles for cancer ablation of the present invention as a means for achieving the object are characterized in that a block copolymer of polyethylene glycol and polystyrene having a phosphorous acid group in the side chain is bound to the surface of ferromagnetic iron oxide particles having a plate-like shape with a length of 20 to 200 nm and a length-to-thickness ratio of 1.5 to 30 and having magnetic properties such that the coercivity is 30 to 300 Oe, the saturation magnetization is 20 to 80 emu/g, and the squareness ratio of the magnetic hysteresis loop is 0.20 to 0.50. | 2015-11-05 |
20150313995 | Magnetic Retention of Regenerative Cells for Wound Repair - Methods are disclosed for promoting wound repair, by magnetically retaining or confining stem cells, or other cells capable of generating the desired tissue, in a target region (e.g., a wound) where tissue regrowth is needed. Also disclosed are magnetic particles and magnetically inducible particles for these methods, as well as sheets comprising magnetic materials. | 2015-11-05 |
20150313996 | COMPOSITION FOR STABILIZING FUSION PROTEIN IN WHICH PROTEIN AND FC DOMAIN ARE FUSED - The present invention relates to a composition for stabilizing a fusion protein of a physiologically active protein and an Fc domain, and more particularly to a method of stabilizing a fusion protein of a protein and an Fc domain using a composition containing an ammonium salt or a combination of an ammonium salt and succinate. The composition containing an ammonium salt or a combination of an ammonium salt and succinate according to the present invention can effectively inhibit the aggregation of the protein-Fc domain fusion protein, and thus enables the fusion protein to be stored for a long period of time. Accordingly, the composition can be widely used in the medical field that uses the protein-Fc domain fusion protein. | 2015-11-05 |
20150313997 | IMMEDIATE RELEASE COMPOSITION RESISTANT TO ABUSE BY INTAKE OF ALCOHOL - The present invention provides immediate release pharmaceutical compositions for oral administration that are resistant to abuse by intake of alcohol. | 2015-11-05 |
20150313998 | DICLOFENAC TOPICAL FORMULATION - The present invention provides a gel formulation comprising diclofenac sodium which has superior transdermal flux properties, which may be used for the topical treatment of pain, such as in osteoarthritis. | 2015-11-05 |
20150313999 | INCREASING THE BIOAVAILABILITY OF FLAVAN-3-OLS BY POLYPHENOLS - The present invention relates generally to the field of flavan-3-ols. In particular, the present invention provides a way to increase the bioavailability of flavan-3-ols. Embodiments of the present invention relate to the use of at least one polyphenolic compound in a composition comprising at least one flavan-3-ol for increasing the bioavailability of said flavan-3-ol, wherein the at least one polyphenolic compound is selected from a group consisting of flavonols, flavones, isoflavones, flavanones, or combinations thereof. | 2015-11-05 |
20150314000 | Pharmaceutically Acceptable Solubilizing Composition and Pharmaceutical Dosage Form Containing Same - Pharmaceutically acceptable solubilizing compositions comprising (i) at least one tocopheryl compound having a polyalkylene glycol moiety and (ii) at least one alkylene glycol fatty acid monoester or mixture of alkylene glycol fatty acid mono- and diester are disclosed. The solubilizing compositions are useful in the manufacture of pharmaceutical dosage forms comprising a melt-processed mixture of at least one active ingredient and at least one pharmaceutically acceptable polymer. The solubilizing compositions enhance the bioavailability of the active ingredient following oral intake. | 2015-11-05 |
20150314001 | LIQUID FORMULATION COMPRISING GM-CSF NEUTRALIZING COMPOUND - The present invention relates to aqueous formulations comprising a compound neutralizing GM-CSF in concentrations of at least about 20 mg/ml, a tonicity modifier and a buffer, wherein the composition is stable. The ingredients of the formulation preferably provide stability to the compound neutralizing GM-CSF in view of long-term storage. In a preferred aspect, the formulation is for use in therapy, preferably for use in the treatment of inflammatory and autoimmune disorders, preferably including allergic and psoriatic disorders, as well as arthritic and asthmatic disorders. Furthermore, a kit comprising the formulation of the invention is provided. | 2015-11-05 |
20150314002 | STABILIZED VANCOMYCIN FORMULATIONS - In one aspect, the invention provides a stabilized lipid-based glycopeptide antibiotic composition and a process for producing the same. In another aspect, the invention provides methods for treating a bacterial pulmonary infection by administering to a subject in need thereof a therapeutically effective amount of the stabilized lipid-based glycopeptide antibiotic composition. | 2015-11-05 |
20150314003 | INJECTABLE SOLUTION AT PH 7 COMPRISING AT LEAST ONE BASAL INSULIN THE ISOELECTRIC POINT OF WHICH IS BETWEEN 5.8 AND 8.5 AND A HYDROPHOBIZED ANIONIC POLYMER - The invention relates to a composition in the form of an injectable aqueous solution, the pH of which is between 6.6 and 7.8, including at least: a) a basal insulin, the isoelectric point pI of which is between 5.8 and 8.5; and b) a hydrophobized anionic polymer. In one embodiment, the compositions according to the invention also include a prandial insulin. | 2015-11-05 |
20150314004 | FREEZE-DRIED EXCIPIENT AND PREPARATION METHOD THEREOF - A freeze-dried excipient and a preparation method thereof. The freeze-dried excipient only comprises an active ingredient and a binder, and does not comprise a support agent. The weight ratio of the active ingredient to the binder is 1:100 to 100:1. The binder is adhesives, cellulose ethers, modified starches, PVP, carbomer, PVA, hyaluronic acids, albumin, chitosan, dextran, agar, polyamino acid, glycan or a combination thereof. | 2015-11-05 |
20150314005 | Compositions and methods for amelioration of diseases and related symptoms in humans - The present invention is generally directed to compositions and methods for amelioration of diseases and related symptoms in humans. In one aspect, the invention is directed to a method of ameliorating the symptoms of arthritis, brain aging, cataracts, diabetes, dermatitis, chronic renal failure, glaucoma, low energy levels or obesity in a human, wherein the method comprises administering a composition to the animal, wherein the composition comprises a Fruit-Based Additive, a Vegetable-Based Additive or a Fruit- and Vegetable-Based Additive. | 2015-11-05 |
20150314006 | PARTICULATE DRUG DELIVERY METHODS - Methods for efficient preparation of drug-polymer (or oligomer) conjugates useful in the preparation of particles, including microparticles and nanoparticles, for delivery of the drug in vivo for therapeutic applications are provided. The invention also provides nanoparticles prepared by nanoprecipitation using drug-polymer/oligomer conjugates of the invention. The drug conjugates are formed during polymerization of the polymer or oligomer in which the drug is employed as an initiator of the polymerization of the monomers which form the polymer and/or oligomer. More specifically, the drug conjugates are formed by ring-opening polymerization of cyclic monomers in the presence of an appropriate ring-opening polymerization catalyst and the initiator (the drug). The method is particularly useful for formation of polymer/oligomer conjugates with drugs and other chemical species containing one or more hydroxyl groups or thiol groups. | 2015-11-05 |
20150314007 | LINKER-PAYLOAD MOLECULE CONJUGATES - The invention relates to novel linker-payload molecule conjugates. The invention also relates to novel cell binder-linker-payload molecule conjugates, in particular antibody conjugates of dolastatin or auristatin derivatives. | 2015-11-05 |
20150314008 | AURISTATIN COMPOUNDS AND CONJUGATES THEREOF - An auristatin compound conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L | 2015-11-05 |
20150314009 | DUAL-ACTION, UNNATURAL PROLINE-RICH PEPTIDES AS ANTIBIOTIC AGENTS AND METHODS THEREOF - The present invention cationic amphiphilic polyproline helices (CAPHs) compounds having increased hydrophobicity and cellular internalization as antimicrobial agents. Antimicrobial compositions and methods of using the same are also provided. | 2015-11-05 |
20150314010 | POTENTIATION OF ANTICANCER AGENTS - The present invention relates to carriers, conjugate and pharmaceutical compositions and their use to increase the potency of drugs and to modify the pharmacokinetics of compounds. More particularly, the present invention relates to conjugates comprising the carrier described herein and their use in the treatment and diagnostic of cancer. | 2015-11-05 |
20150314011 | AMPHIPATHIC PEPTIDE - The present invention is directed to an amphipathic peptide and methods of using the amphipathic peptide for delivering small molecule agents to a cell. Ideally, the amphipathic cell penetrating peptide comprises less than approximately 50 amino acid residues with at least 6 arginine residues, at least 12 Alanine Residues, at least 6 leucine resiues, optionally at least one cysteine residue, and at least two but no greater than three glutamic acids wherein the arginine residues are evenly distributed along the length of the peptide; and the peptide has a defined ratio of arginine to negatively charged amino acid residues and a defined ratio of hydrophilic amino acid residues to hydrophobic amino acid residues. The present invention is also directed to a nanoparticle and cell delivery system comprising the amph ipathic cell penetrating peptide of the invention. The peptide, nanoparticle or cell delivery sys tem of the invention may be used in therapy. For example, the peptide may be used as a therapeutic agent delivery system, in which the therapeutic agent may include nucleic acids or other small molecules. | 2015-11-05 |
20150314012 | Protein Conjugates - The present invention concerns the field of conjugated peptides suitable for the production of drugs having an improved plasma half-life. In particular the present invention relates to a conjugated protein, obtained by an enzymatic reaction via microbial transglutaminase (MTGase), and an improved process for removing residual transglutaminase from peptides or recombinant proteins enzymatically conjugated by microbial transglutaminase (MTGase) to hydrophilic non-immunogenic polymer at a glutamine side-chain through an amidic linkage, allowing to obtain purified conjugated peptides or proteins which are stable against the enzymatic hydrolysis of the amidic bond between the peptide or protein moiety and the hydrophilic polymer and being free from product derived degradation displays the stability required for a drug. | 2015-11-05 |
20150314013 | COMPOSITIONS AND METHODS FOR POLYNUCLEOTIDE TRANSFECTION - A pharmaceutical composition comprising a peptide-polynucleotide complex, and methods of use thereof. | 2015-11-05 |
20150314014 | Inhibitor which is deactivatable by a reagent produced by a target cell - The invention relates to molecules inhibiting biologically active compounds and further comprising moieties specifically cleavable by a reagent produced by a target cell. More specifically, the invention relates to inhibitors that bind, inhibit, suppress, neutralize, or decrease activity of a biologically active agent. Inhibitors comprise at least one moiety that bind, inhibit, suppress, neutralize, or decrease activity of a biologically active agent and at least one moiety that can be cleaved specifically by a reagent produced by target cells. The cleavage deactivates the inhibitor. Following cleavage, the active agent is liberated into the local environment. Administration of the inhibitor alone or together with the active agent suppress the compound's activity until it reaches the proximity of a target cell. This targeted specific release enables the agent concentration in a site to reach levels that have desired therapeutic effects without systemic toxicity. The invention also relates to production and uses of the inhibitors in diagnosis and treatment of a disease. | 2015-11-05 |
20150314015 | VITAMIN RECEPTOR DRUG DELIVERY CONJUGATES FOR TREATING INFLAMMATION - Described herein are compositions, methods, compounds, conjugates, and kits for use in targeted drug delivery using drug delivery conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations, such as inflammatory cells. | 2015-11-05 |
20150314016 | ANTI-CD79B ANTIBODIES AND IMMUNOCONJUGATES AND METHODS OF USE - The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same. | 2015-11-05 |
20150314017 | DISULFUR BRIDGE LINKERS FOR CONJUGATION OF A CELL-BINDING MOLECULE - The present invention relates to novel disulfur bridge linkers containing hydrazine used for the specific conjugation of compounds/cytotoxic agents to a cell-binding molecule, through bridge linking a pair of thiols on the cell-binding molecule. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders. | 2015-11-05 |
20150314018 | METHOD FOR CELLULAR RNA EXPRESSION - The present invention relates to expressing RNA in cells and, in particular, enhancing viability of cells in which RNA is to be expressed. Specifically, the present invention provides methods for expressing RNA in cells comprising the steps of preventing engagement of IFN receptor by extracellular IFN and inhibiting intracellular IFN signalling in the cells. Thus, preventing engagement of IFN receptor by extracellular IFN and inhibiting intracellular IFN signalling in the cells allows repetitive transfer of RNA into the cells. | 2015-11-05 |
20150314019 | FUNCTIONALIZED ULTRABRIGHT FLUORESCENT SILICA PARTICLES - A method for synthesizing ultrabright fluorescent silica particles with hydrophilic functional groups, comprising the steps of: (i) forming a first mixture comprising a plurality of nano-sized silica particles and a gelation agent; (ii) forming a second mixture by combining the first mixture with a surfactant, a plurality of fluorescent dye molecules, and water, wherein fluorescent dye molecules are encapsulated within a plurality of pores of the nano-sized silica particles; (iii) forming a third mixture by adding a co-source of silica to the second mixture, wherein the co-source of silica prevents leakage of the encapsulated fluorescent dye molecules from the pores of the nano-sized silica particles and provides hydrophilic functional groups to the silica particles while preserving the fluorescence of the silica particles; (iv) optional further functionalization of the obtained nanoparticles with functional molecules, exemplified by carboxylic groups and folic acid, and (v) removing excess fluorescent dye from the third mixture. | 2015-11-05 |
20150314020 | COMPOSITIONS AND METHODS USING MICROSPHERES AND NON-IONIC CONTRAST AGENTS - The present invention relates to compositions and methods for treating diseases and disorders including cancer and various other angiogenic-dependent diseases, vascular malfunctions, arteriovenous malformations (AVM), hemorrhagic processes and treatment of pain, in particular tumor-related pain by drug delivery and/or therapeutic embolization using microspheres. More particularly the invention relates to microspheres containing non-ionic contrast agents, to compositions comprising these microspheres, as well as methods for preparing and using such compositions for embolization therapy. The invention further relates to compositions and methods using detectable microspheres for targeted drug delivery, irrespective of whether embolization is also needed. | 2015-11-05 |
20150314021 | STERILIZATION METHOD COMPRISING STERILIZATION FLUID AND ULTRASONICALLY GERERATED CAVITATION MICROBUBBLES - A sterilization method and apparatus uses ultrasonic vibrations and a sterilant bath, preferably ozone or hydrogen peroxide, for cleaning, disinfecting or sterilizing an article, whereby the ultrasonic vibrations generate cavitation microbubbles for damaging microbiological forms in the bath or on the article. The cavitation microbubbles have a diameter of 1-20 microns, preferably 1-10 microns. The use of cavitation microbubbles makes the method and apparatus more effective against microbiological forms. The cavitation microbubbles are generated at ultrasonic vibration frequencies above 100 k Hz and up to 2 Mhz, preferably 250 k Hz to 2 MHz and most preferably at about 500 k Hz. | 2015-11-05 |
20150314022 | STERILIZATION PROCESS DESIGN FOR A MEDICAL ADHESIVE - Medical devices, including medical adhesives, need to be sterile before application to a patient. A dry heat sterilization process can sterilize medical adhesives for patient application. The dry heat sterilization process can be validated for particular equipment arrangements and medical adhesives being utilized. | 2015-11-05 |
20150314023 | TOOTHBRUSH AND RAZOR HOLDER AND SYSTEM FOR PROLONGING THE USEFUL LIFE OF TOOTHBRUSHES AND RAZORS - A system for and method of sanitizing a toothbrush and a razor is provided. The system includes a base member that is configured to support a pair of containers such that at least some light emitted from a sanitizing light propagates into an interior area of each container so as to sanitize the bristles of the toothbrush and the blades of the razor. The method includes pouring a first cleaning fluid, such as mouthwash, into the first container and a second cleaning fluid, such as rubbing alcohol, into the second container. The toothbrush and razor are then placed head-first into the first and second containers, respectively, such that the bristles of the toothbrush and the blades of the razor are completely submerged in respective cleaning fluids. A sanitizing light is then directed towards the bristles of the toothbrush and the blades of the razor. | 2015-11-05 |
20150314024 | METHOD AND APPARATUS FOR LIQUID DISINFECTION BY LIGHT EMITTED FROM LIGHT EMITTING DIODES - An ultraviolet (UV) liquid treatment apparatus is disclosed. The apparatus may include a conduit having an inlet to receive liquid to be treated and an outlet to discharge treated fluid, the conduit defining a plurality of liquid flow paths between the inlet and the outlet. The apparatus may further include an UV light emitting diode (LED) module array to illuminate the liquid, wherein the UV LED module array comprises a plurality of UV LED modules arranged on a curved surface of an array holder, such the UV LED module array is configured to generate a customized spatial light flux distribution within the conduit that matches the liquid flow paths so as to obtain a desired UV dose distribution. | 2015-11-05 |
20150314025 | Synergistic Disinfection Enhancement - An aqueous disinfectant solution comprising peroxyacetic acid and a surfactant such as a polyoxyethylene alkyl ether phosphate, (polyethylene glycol p-(1,1,3,3-tetramethylbutyl)-phenyl ether) or cocoamidopropylamino oxide. The solution is preferably adjusted to provide a pH in the range 5-8 by a pH adjusting agent such as a phosphate buffer; hydroxide; carbonate; bicarbonate; a combination of carbonate and hydroxide; or a combination of carbonate and bi carbonate. | 2015-11-05 |
20150314026 | MOBILE STERILIZATION APPARATUS AND METHOD FOR USING THE SAME - A mobile sterilization system comprising: a sterilization cabinet, the sterilization cabinet comprising: a bottom panel, a top panel, two side panels, a back panel and a door configured so as to define an interior chamber; a plurality of casters or wheels mounted to the bottom panel, each of the plurality of casters or wheels being mounted to the bottom panel by a caster or wheel bracket, wherein the caster or wheel bracket comprises a lateral projection; perforations formed in at least one of the bottom panel, top panel and two side panels; and at least one filter configured to cover the perforations; and a transfer cart, the transfer cart comprising: an upper platform for receiving a sterilization cabinet, the upper platform comprising a pair of transfer cart tracks extending longitudinally along the upper platform, wherein each of the transfer cart tracks comprises a lateral projection; and a lower support structure for supporting the upper platform and for receiving wheels; wherein the sterilization cabinet is received on the transfer cart such that the lateral projections of the caster or wheel brackets engage the lateral projections of the transfer cart tracks, whereby to prevent side-to-side and up-and-down movement of the sterilization cabinet relative to the transfer cart. | 2015-11-05 |
20150314027 | COMPOSITION FOR ODOR REMOVAL COMPRISING CUCURBITURIL - Disclosed herein is a composition for removing odor, the composition including cucurbituril. The composition can capture and remove various kinds of odor materials (particularly, ammonium ion-containing bad odor, such as a fishy smell or the like) because cucurbituril can interact with various odor materials using its hydrophobic cavity and both inlets covered with carbonyl groups. Therefore, this composition can be practically applied to the cleaning of air and the improvement of an environment. | 2015-11-05 |
20150314028 | AROMA DIFFUSING NIGHT LAMP ASSEMBLY - An aroma-diffusing night lamp assembly includes a body holding a coupling socket at the top, a lamp bulb inserted into the coupling socket and electrically connected to the body, a lampshade defining a bottom coupling hole coupled to the coupling socket and a top opening for holding an aroma capsule, and an aroma capsule including a disposable heat-transfer container mounted in the top opening of the lampshade and an aromatic substance contained in the disposable heat-transfer container and heatable by the radiating heat energy of the lamp bulb to release an aromatic smell. | 2015-11-05 |
20150314029 | Decontamination Device and Method - The present invention relates to a device and method for decontamination. The device and method can be used to eradicate airborne and surface organic molecules and microorganisms, including pathogens, bacteria, and imbedded odors either on surfaces or items. The device includes a means to generate vapor-phase hydrogen peroxide, purified ozone and hydrogen radicals using UV light which treats fluids in multi-chambers, with passive or active mixing of the fluids taking place, prior to release of the treated fluid onto the surfaces or items to be treated. The method includes use of the device noted in an enclosed space, operated at a specified temperature and relative humidity range, by an operator outside the enclosed space. The surfaces and items are placed within the enclosed space for treatment. | 2015-11-05 |
20150314030 | AIR FRESHENER - An air freshener removably engages with a structure, such as the supporting post of a rear view mirror of a motor vehicle. The air freshener has a rigidifying core defining a central axis, and an outer portion or sleeve contacting the core that is formed from one or more fragrance loaded polymers. Together, the core and outer portion are shaped to surround a first axis perpendicular to the central axis. The ends of the air freshener are juxtaposed generally opposite one another in closed configuration, and the arm portions of the air freshener flex in directions substantially parallel to the first axis to separate the ends to open the air freshener. A breakable strap and/or connectors may be provided to join the ends together. Alternatively, one end of the air freshener may be inserted within a cavity formed in the opposite end of the air freshener. | 2015-11-05 |
20150314031 | Dispenser For Air Freshener Containers - The dispenser can be used with air fresheners including a container ( | 2015-11-05 |
20150314032 | DISPENSER SYSTEM FOR AEROSOL AND NON-AEROSOL PRODUCTS - A dispensing system for air care products contained in aerosol and non-aerosol containers having spray nozzles includes a dispenser including a contoured surface that is configured to accept an aerosol container within the interior of the dispenser, the dispenser further including an adaptor releasably attached to the contoured surface of the dispenser, the adaptor configured to retain a non-aerosol container within the interior of the dispenser such that the actuator may contact the non-aerosol spray nozzle. | 2015-11-05 |
20150314033 | FIBERGLASS DIELECTRIC BARRIER IONIZATION DISCHARGE DEVICE - A bipolar ionization device in which fiberglass is used as the dielectric. In one embodiment, a fiberglass board is used, with the anode on one side of the board and the cathode on the other side of the board. A number of flat boards can be stacked, with spacing between them to allow air flow to scavenge ions, with stanchions providing both mounting and electrical connections to the ionization devices. In another embodiment, a fiberglass tube is used, with the cathode inside the tube and the anode outside the tube. | 2015-11-05 |
20150314034 | PROCESS FOR PRODUCING WATER-ABSORBING POLYMER PARTICLES - A process for preparing water-absorbing polymer particles, comprising polymerisation of a foamed monomer solution or suspension, drying, grinding, classification and spray-coating the water-absorbing polymeric particles with an elastic film-forming polymer in a fluidised bed reactor in the range from 0° C. to 50° C. and heat-treating the coated particles at a temperature above 0° C. | 2015-11-05 |
20150314035 | FIBROIN-CONTAINING HYDROGELS FOR PELVIC TISSUE TREATMENT - The disclosure provides compositions, systems, and methods for the treatment of pelvic tissue conditions that include use of a silk fibroin-containing hydrogel composition. The composition includes water-soluble fibroin and a water-soluble crosslinkable polymer. The composition can be used as a pre-formed hydrogel or can be delivered to a pelvic tissue site and crosslinked in situ to form a hydrogel. The composition can be used to promote tissue closure, such as vaginal wound or fistula closure. The composition can also be used to enhance attachment or anchoring of a pelvic implant to a pelvic tissue. A hydrogel delivered to a pelvic tissue site, or formed at the site in situ, is associated with a portion of the implant (e.g., a mesh implant) via a tether or implant extension portion, thereby providing improved immobilization of the implant. Systems or kits that include the composition and a delivery needle or insertion tool are also described. | 2015-11-05 |
20150314036 | WOUND HEALING DEVICE - A plasma coating device for treating a wound comprises a plasma chamber having: one or more electrodes, a gas supply inlet, a plasma outlet exposed to ambient pressure, and an ignition system operatively connected to the electrodes for providing a non-thermal equilibrium plasma within the plasma chamber. An aerosol delivery system is operable to introduce a bioresorbable material as an aerosol into the plasma, to produce a coating on the wound surface. | 2015-11-05 |
20150314037 | HEMOSTATIC FOAM - The invention discloses a pharmaceutical hemostatic liquid foam base preparation comprising albumin as foaming agent and a fibrinogen precipitating substance and optionally a coagulation inducing agent, wherein albumin as foaming agent is present in native form; a method for the production of a transient hemostatic liquid foam; the transient hemostatic liquid foam; and a kit for making the foam. | 2015-11-05 |
20150314038 | High Temperature Melting - The present invention relates to methods for making wear and oxidation resistant polymeric materials by high temperature melting. The invention also provides methods of making medical implants containing cross-linked antioxidant-containing tough and ductile polymers and materials used therewith also are provided. | 2015-11-05 |
20150314039 | ABSORBANT AND REFLECTING BIOCOMPATIBLE DYES FOR HIGHLY ACCURATE MEDICAL IMPLANTS - A light-polymerizable composition for additive manufacturing of resorbable scaffolds and implants comprising a biocompatible resin. The biocompatible resin includes a combination of photo-initiators or a dye-initiator package tailored to manufacture implants with the desired physical and chemical properties. A dye or other constituent controls between layer (z) resolution of the manufactured part built in an additive manufacturing device. A light absorber or other constituent controls within layer (x-y) resolution of the manufactured part. | 2015-11-05 |
20150314040 | STABLE HYDROGEL COMPOSITIONS INCLUDING ADDITIVES - The present specification generally relates to hydrogel compositions and methods of treating a soft tissue condition using such hydrogel compositions. | 2015-11-05 |
20150314041 | Apparatus for enhanced recovery of regenerative cells from tissue samples - This document describes methods and an apparatus for recovery of a cell-enriched matrix and cells (e.g., regenerative cells) from a tissue sample. In some embodiments, at least two rounds of acceleration and deceleration are performed. | 2015-11-05 |
20150314042 | BIOPROSTHETIC TISSUE HAVING A REDUCED PROPENSITY FOR IN VIVO CALCIFICATION - A bioprosthetic tissue having a reduced propensity to calcify in vivo, the bioprosthetic tissue. The bioprosthetic tissue comprises an aldehyde cross-linked and stressed bioprosthetic tissue comprising exposed calcium, phosphate or immunogenic binding sites that have been reacted with a calcification mitigant. The bioprosthetic tissue has a reduced propensity to calcify in vivo as compared to aldehyde cross-linked bioprosthetic tissue that has not been stressed and reacted with the calcification mitigant. | 2015-11-05 |
20150314043 | TISSUE PROCESSING APPARATUS AND METHOD - A tissue treatment apparatus and method for treating biologic tissue has a controller, an enclosure, a reagent supply system, a draining configuration, and a gas relief valve is controlled by the controller. Optionally provided is a gas evacuation assembly, a gas supply unit, a thermal unit for heating or cooling reagents or gases, a sonication unit, any or each operated by the controller. The method provides for programming controller to effect a treatment procedure. In an embodiment of the present application the tissue sample is bone material and the treatment procedure effects demineralization of the bone material | 2015-11-05 |
20150314044 | METHOD FOR IN VIVO HAIR MULTIPLICATION - Cosmetic methods providing a significant improvement over existing hair transplantation methods by providing greater hair density per hair implant, which is achieved through the process of an enhanced hair multiplication in vivo (e.g. in the scalp of a subject). The cosmetic methods also provide improved aesthetic results, particularly, more realistic and natural looking results, relative to the results obtained by traditional methods. The cosmetic methods are particularly suitable for hair transplantation in recipient areas of a subject experiencing baldness or lack of hair, optionally due to Androgenic alopecia, burn injuries, cancer chemotherapy, or other genetic or environmental factors or scarring. | 2015-11-05 |
20150314045 | BIO-MATERIAL COPOSITION AND METHOD OF USE - The present invention relates to a bio-material composition and methods of use. Among the preferred embodiments are methods for fusing objects to bone and methods for fixing bone voids without the need for BMP-2. One or more preferred embodiments relate to methods for fusing objects (including bone, tendons, ligaments and implants) to bone using the invented bio-material composition. | 2015-11-05 |
20150314046 | BIODEGRADABLE MEDICAL DEVICE HAVING AN ADJUSTABLE DEGRADATION RATE AND METHODS OF MAKING THE SAME - Disclosed herein are biodegradable medical devices comprising biodegradable materials (e.g., magnesium-calcium alloys) having an adjustable rate of degradation that can be used in various applications including, but not limited to, drug delivery applications, cardiovascular applications, and orthopedic applications to make biodegradable and biocompatible devices. Also disclosed herein are methods of making biodegradable medical devices comprising biodegradable materials by using, for instance, hybrid dry cutting/hydrostatic burnishing. | 2015-11-05 |
20150314047 | BORON COMPOSITE SURFACE COATINGS AND THEIR APPLICATION ON IMPLANTABLE DEVICES TO ACCELERATE OSSEOUS HEALING - The present invention discloses boron composite surface coatings, application of these coatings onto implantable devices, and use of the implantable devices for accelerating osseous healing. The implantable devices have wide applications, including but not limited to treating bone fracture, bone trauma, arthrodesis, and other bone deficit conditions, as well as bone injuries incurred in military and sports activities. | 2015-11-05 |
20150314048 | SURGICAL FLUID MANAGEMENT SYSTEMS AND METHODS - A surgical fluid management system delivers fluid for distending a uterine cavity to allow cutting and extraction of uterine fibroid tissue, polyps and other abnormal uterine tissue. The system comprises a fluid source, fluid deliver lines, one or more pumps, and a filter for re-circulating the distension fluid between the source and the uterine cavity. A controller can monitor fluid retention by the patient. | 2015-11-05 |
20150314049 | ADAPTIVE TUBING CASSETTES FOR USE IN CONNECTION WITH INTERVENTIONAL CATHETER ASSEMBLIES - Peristaltic pump assemblies in which the closing and opening of a pivoting or sliding door is coordinated with movement of the occlusion bed toward and away from the rotor assembly to engage and disengage tubing within the occlusion pathway are disclosed. Linkage mechanisms provided by the interaction of cam surfaces with rollers, as well as bar linkage mechanisms, are disclosed. The linkage mechanism, in addition to providing precise displacement of the occlusion bed, may also provide an over-center feature that enhances safety and pump operation when the door is in a closed position. Latching mechanisms and sensors may be incorporated. Control consoles incorporating such peristaltic pump assemblies are described. Adaptive components such as tubing cassettes routing aspiration and/or infusion tubing in a predetermined configuration to mate with occlusion pathways in aspiration and/or infusion pump assemblies provided in various types of medical devices and control consoles are also provided. | 2015-11-05 |
20150314050 | SURGICAL SUCTION DEVICE - A surgical suction device including: a) a housing defining an internal chamber and including: i) an inlet for receiving material extracted from a subject via a hollow tip including one or more suction openings for receiving the materials from a surgical site on the subject; and, ii) an outlet for coupling the housing to a suction source to allow material to be drawn therethrough; and, b) a mixing apparatus including one or more mixing members positioned inside the chamber for agitating material passing through the chamber from the inlet to the outlet in use to thereby prevent the material clogging the outlet. | 2015-11-05 |
20150314051 | Systems and Methods For Positioning Fluid Supply System - Fluid supply systems and methods for therapeutic fluid delivery systems, including those used for negative pressure wound therapy (NPWT) systems and methods. | 2015-11-05 |
20150314052 | WOUND DRESSING PORT AND ASSOCIATED WOUND DRESSING - A wound dressing for use in a vacuum wound therapy treatment includes a backing layer for positioning over a wound to define a reservoir in which a reduced pressure may be maintained over the wound. A portal member affixed to the backing layer provides a connection to a reduced pressure source through an opening in an ambient surface. A primary port extends between the opening and a primary aperture in a reservoir surface to providing fluid communication between the reservoir and the reduced pressure source. At least one supplemental port establishes fluid communication between the primary port and a supplemental aperture in the reservoir surface that is distinct and substantially spaced from the primary aperture. | 2015-11-05 |
20150314053 | BREAST SHIELD UNIT - A breastshield unit for use with a breastpump for expressing human breastmilk using underpressure has a dimensionally stable breastshield and a flexible breastshield insert for placing in the breastshield. The breastshield has a first, open breastshield end for placing on a mother's breast. The breastshield insert has a first insert end and a second insert end which define a longitudinal direction, the first, open breastshield end having a peripheral edge on which the breastshield insert is securable with the first insert end. In the assembled state, the breastshield insert extends from this first insert end through the inside of the breastshield to the second insert end, wherein the breastshield insert, between the first and second insert ends, extends substantially spaced apart from the breastshield. In the assembled state of the breastshield insert, the second insert end is displaceable in the longitudinal direction relative to the breastshield. The breastshield unit adapts optimally to the shape of the mother's breast and optimizes the bearing force. | 2015-11-05 |
20150314054 | PERMANENT TOTAL ARTIFICIAL HEART DEVICE - The invention is about a permanent total artificial heart device that is developed for the patients who are at the end-stage heart failure and included in the heart transplantation program, and which is placed into the ventricles of the patient's heart completely or placed surgically into the space obtained when a piece of ventricle is removed. The device employs “direct drive technology,” technically using the advantages of brushless electric motors. Special-designed engines require quite little energy for the pulsatile blood flow produced by stopping and starting synchronously with the ECG signals. It is about a permanent total artificial heart device system that will offer high quality of life for many years to the patients as it protects the heart valves and heart conduction system, has wireless charging and longer battery life. | 2015-11-05 |
20150314055 | DIALYSIS SYSTEM AND METHODS - Dialysis systems and methods are described which can include a number of features. The dialysis systems described can be to provide dialysis therapy to a patient in the comfort of their own home. The dialysis system can be configured to prepare purified water from a tap water source in real-time that is used for creating a dialysate solution. The dialysis systems described also include features that make it easy for a patient to self-administer therapy. For example, the dialysis systems include disposable cartridge and patient tubing sets that are easily installed on the dialysis system and automatically align the tubing set, sensors, venous drip chamber, and other features with the corresponding components on the dialysis system. Methods of use are also provided, including automated priming sequences, blood return sequences, and dynamic balancing methods for controlling a rate of fluid transfer during different types of dialysis, including hemodialysis, ultrafiltration, and hemodiafiltration. | 2015-11-05 |
20150314056 | Manifold For Wearable Artificial Kidney - Flexible manifolds configured for use in a wearable artificial kidney are provided and can include an array of manifold plates defining one or more flow path and which are adapted to receive dialysis components including cleaning columns and dialyzers. Wearable artificial kidneys are also provided. For example, a wearable artificial kidney can include a flexible manifold, a first flow path, a second flow path, a third flow path, a first cleaning column, a first dialyzer, a second dialyzer, a second cleaning column, and at least one pump. Systems for performing dialysis are further provided. The systems can include a wearable artificial kidney and manifold inlet and outlet lines for connecting the peritoneum of a dialysis patient to the wearable artificial kidney. Methods for performing dialysis utilizing the flexible manifolds, wearable artificial kidneys, and systems containing the same, are also provided. | 2015-11-05 |
20150314057 | BLOOD PROCESSING CARTRIDGES AND SYSTEMS, AND METHODS FOR EXTRACORPOREAL BLOOD THERAPIES - In embodiments of the invention, there is provided a dialyzer or filter comprising hollow fibers, in which blood flows on the exterior of the hollow fibers, and dialysate or filtrate may flow on the inside. The external surfaces of the hollow fibers may have properties of smoothness and hemocompatibility. The fiber bundle may have appropriate packing fraction and may have wavy fibers. Optimum shear rates and blood velocities are identified. Geometric features of the cartridge, such as pertaining to flow distribution of the blood, may be different for different ends of the cartridge. Air bleed and emboli traps may be provided. Lengthened service life may be achieved by combinations of these features, which may permit additional therapies and applications or better economics. | 2015-11-05 |
20150314058 | DIAPHRAGM REPOSITIONING FOR PRESSURE POD USING POSITION SENSING - Pressure measurement system (e.g., for an extracorporeal treatment system), method and pressure pod apparatus including a position sensor for use in repositioning a diaphragm that separates a liquid side cavity from a transducer side cavity (e.g., operatively connected to a pressure transducer); the liquid side cavity being in fluid communication with an inlet and an outlet. | 2015-11-05 |
20150314059 | EXTRACORPOREAL AMBULATOR ASSIST LUNG - A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moving element to create velocity fields in blood flow contacting the plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers may extend generally perpendicular to the direction of bulk flow of blood through the housing. | 2015-11-05 |
20150314060 | FAT REMOVAL FROM BLOOD - A system for removing undesirable elements from blood. The system includes a centrifuge bowl to separate the blood into components according to relative densities of the components, a pump to provide wash solution that washes the blood in the centrifuge bowl, and a controller to wash the blood in the centrifuge bowl in a first wash and remove first undesirable elements and to wash the blood in the centrifuge bowl in a second wash and remove trapped undesirable elements. The controller to further mix the blood and the wash solution in the centrifuge bowl and provide diluted blood, separate the diluted blood into concentrated blood and the wash solution, fill the centrifuge bowl with previously concentrated blood to build a buffy coat, and empty the centrifuge bowl of the concentrated blood and the previously concentrated blood after the buffy coat is reached. | 2015-11-05 |
20150314061 | NASAL RINSE TIP - A device for nasal lavage is described. The device ejects a gentle flow of fluid under pressure. The fluid stream provides a high quantity of fluid at low pressure. The low pressure fluid stream is more comfortable for a user than a high pressure fluid stream that are delivered by various types of pressurized cans of solution. | 2015-11-05 |
20150314062 | PUMP WITH THERAPY COACHING - An apparatus comprising a pump, an input configured to receive information related to a user, a user interface, and a controller communicatively coupled to the pump, the input, and the user interface. The controller includes a timing module configured to initiate delivery of a drug in time and to adjust delivery according to the received information. Other devices, systems, and methods are disclosed. | 2015-11-05 |
20150314063 | DELIVERY OF A THERAPEUTIC FLUID - Systems, methods and devices for delivering a therapeutic fluid into tissue are disclosed. The system includes an infusion set having a catheter for delivery of a dose of therapeutic fluid into a tissue via an infusion tube, a treatment element that applies treatment to the tissue proximate to the catheter, a catheter adaptor having a first transponder, a pump adaptor, in communication with the catheter adaptor, having a second transponder that communicates with the first transponder, and an infusion detection sensor that detects an infusion of the therapeutic fluid. Upon detection of an infusion of the therapeutic fluid by the infusion detection sensor, the second transponder communicates a signal indicative of the detected infusion to the first transponder causing the catheter adaptor to apply treatment using the treatment element. At least one of a strength and a duration of the treatment corresponds to a dose of the infused therapeutic fluid. | 2015-11-05 |
20150314064 | IMPLANTABLE DRUG-DELIVERY DEVICES, AND APPARATUS AND METHODS FOR FILLING THE DEVICES - In various embodiments, a tool is employed in filling a drug-delivery device. The tool may include, for example, a needle that is admitted through a fill port of the drug-delivery device. | 2015-11-05 |
20150314065 | Methods and Devices for Delivering GLP-1 and Uses Thereof - The invention provides various devices for delivering Glucagon-Like Peptide-1 (7-36), in various infusion patterns and rates, to optimally stimulate carbohydrate metabolism, to inhibit gastropancreatic secretion and gastric motility, and to treat various disease conditions (including diabete) as described in the instant specification. The devices and methods of the invention provide various ways to deliver doses (escalating, constant, on demand, etc.) of GLP-1 in response to different patient need. | 2015-11-05 |
20150314066 | INFUSION PUMP - Provided is an infusion pump in which one or more occlusion sensors includes a Hall element detecting a variation in magnetic flux, of one or more magnets, generated with movement of a plunger caused by a variation of an infusion tube in a radial direction that results from an occlusion of the infusion tube, and changing the variation of an infusion tube in the radial direction into an output voltage. When increasing a movement distance of the plunger to a plurality of predetermined positions D | 2015-11-05 |
20150314067 | SAFETY NEEDLE DEVICE, PARTICULARLY FOR THE PUNCTURE OF A PORT IMPLANTED SUBCUTANEOUSLY IN A HUMAN OR ANIMAL BODY - The invention relates to a safety needle device, particularly for the puncture of a port implanted subcutaneously in a human or animal body, comprising a first housing; a hollow needle, wherein the needle has a first sub-section and a second sub-section, and the first sub-section extends along a puncture axis, which runs at a right angle to the surface of the human or animal body, and the second sub-section of the needle being arranged at a right angle to the first sub-section, substantially parallel to the surface of the human or animal body, wherein the hollow needle is or can be connected to the first housing, particularly in the region of the second sub-section; a cover comprising a through-hole for receiving the first sub-section of the needle, wherein the cover can be moved from a first position into a second position relative to the first housing, wherein the movement occurs substantially along the puncture axis; and an at least partially flexible limiting element for limiting the relative movement between the first housing and the cover in the second position; wherein the device is characterized in that the cover has, on the surface facing away from the human or animal body, a guide sleeve for the first sub-section of the needle. | 2015-11-05 |
20150314068 | DETECTING BLOCKAGE OF A RESERVOIR CAVITY DURING A SEATING OPERATION OF A FLUID INFUSION DEVICE - A fluid infusion device and related operating methods are presented here. An exemplary embodiment of the device includes a drive motor assembly, a force sensor associated with the drive motor assembly, and a reservoir cavity that accommodates fluid reservoirs. An exemplary operating method for the device obtains force measurements for a reservoir seating action of the drive motor assembly, where the force measurements indicate measures of force imparted to the force sensor during the reservoir seating action. The method continues by determining that a vent in the reservoir cavity is blocked, based on an analysis of the force measurements, and by initiating corrective action for the fluid infusion device in response to determining that the vent in the reservoir cavity is blocked. | 2015-11-05 |
20150314069 | Infusion Pump Systems and Methods - Some embodiments an infusion pump system can be used to determine a user's total insulin load (TIL) that provides an accurate indication of the insulin previously delivered to the user's body which has not yet acted. In particular embodiments, the TIL can account for both the bolus deliveries and the basal deliveries that have occurred over a period of time. Such information may be useful, for example, when the infusion pump is operated in conjunction with a continuous glucose monitoring device. | 2015-11-05 |
20150314070 | Chemical Engines and Methods for Their Use, Especially in the Injection of Highly Viscous Fluids - Chemical engines and processes for their use and construction are described. The chemical engines can provide powerful and compact devices, especially autoinjectors for the rapid, powered injection of viscous medicines. Novel formulations and designs of chemical engines and delivery technologies employing the chemical engines are described. | 2015-11-05 |
20150314071 | Valve Permitting Mixing in a Drug Delivery Device | 2015-11-05 |
20150314072 | DOSING MECHANISM - A dosing mechanism ( | 2015-11-05 |
20150314073 | AUTOMATIC INJECTION DEVICE - Automatic injection device includes a housing, a syringe, a plunger, and a syringe carrier. The housing includes a barrel. The barrel includes an elongated window to allow viewing of contents inside the housing. The syringe is disposed within the housing and has a reservoir. The plunger is at least partially disposed within the syringe and includes a visual indicator. The syringe carrier is disposed within the housing and configured to contain the syringe and displace the syringe within the housing between a first position and a second position. The syringe carrier can have at least one opening and at least one pair of legs defining at least a portion of the at least one opening. | 2015-11-05 |
20150314074 | Apparatus And Methods For Purging Catheter Systems - Apparatus and methods for providing controlled pressure-flow pulses which purge a catheter system with turbulent flow flushing. Accomplishment of such controlled pressure-flow pulses is provided by a variety of inventive devices including a special plunger rod for a conventional syringe, other interactive parts for conventional syringes, an in-line catheter attachable device which automatically generates the controlled pressure-flow pulses and also single pulse, digitally operated devices. | 2015-11-05 |
20150314075 | CLUTCH MEMBER FOR AN INJECTION DEVICE - An injection device includes a housing ( | 2015-11-05 |
20150314076 | Automatic Injection Device with a Top Release Mechanism - The present invention relates to a handheld mechanical injection device by which set doses of a liquid medicament can be injected from a medical reservoir. The medicament is expelled through an injection needle by release of a power reservoir in the device, the power reservoir being fully or partially released by actuation of a user operable release member being positioned at or near an upper end of the injection device, the upper end being that end of the injection device which is opposite the injection needle. | 2015-11-05 |
20150314077 | Injection Needle Assembly - The present invention relates to an injection needle assembly ( | 2015-11-05 |
20150314078 | DISPENSING APPARATUS - A dispensing apparatus for a flowable component includes a storage container, an applicator and a closure element. The storage container has a storage chamber configured to receive the component, an outlet flange and a component outlet. The applicator has a component inlet and a dispensing opening, and is connected to the storage container by the outlet flange establishing a connection between the component outlet of the storage container and the component inlet of the applicator. The closure element is independent from the applicator, and configured to selectively adopt a closed position and a dispensing position, the component outlet is closed in the closed position and open in the dispensing position, and is configured to be coupled to the applicator so as to be brought from the closed position into the dispensing position by a rotation of the applicator in a connection direction with respect to the storage container. | 2015-11-05 |
20150314079 | NEEDLE BASE RETRACTABLE-TYPE SAFE SELF-LOCKING-TYPE SELF-DESTRUCTING SYRINGE - A retractable-type safe self-locking-type self-destructing syringe, which comprises a syringe barrel body ( | 2015-11-05 |
20150314080 | Needle Mounting Feature for Ensuring Proper Reconstitution Sequence - In one aspect, a medical injector is provided herein having a body and an overcap releasably attached to the body configured to prevent mounting of a needle prior to mixing of components within the body. In a further aspect, a slidable collet may be provided useable to urge resilient members from an outward disrupted state inwardly to collectively define a needle mount. Advantageously, a medical injector is provided which ensures proper sequence in preparation of the device, particularly with respect to the step of allowing mounting of a medical needle to the device subsequent to preparation of the medicament to be administered. | 2015-11-05 |
20150314081 | INJECTION SENSOR WITH FEEDBACK MECHANISM - The present disclosure provides devices for implanting tissue or other substances within the body. The devices can include a feedback mechanism, which can assist a surgeon in implanting the tissue or other substances by preventing excess shear force or pressure on the tissue or substance to be implanted. | 2015-11-05 |
20150314082 | Dispense Interface with Lockout Element - The invention relates to a dispense interface for use with a drug delivery device with an inner body and with a lockout element, wherein the lockout element is coupled to the inner body, wherein the lockout element is movable from a receptive condition to a locked condition, wherein in the receptive condition the dispense interface is attachable to the drug delivery device, wherein in the locked condition the dispense interface is not-attachable to the drug delivery device and wherein the lockout element is configured to move from the receptive condition to the locked condition when said dispense interface is attached to and detached from said drug delivery device. The invention solves the technical problem of reducing the risk of reuse of a dispense interface, after it has already been used with a drug delivery device. The invention furthermore relates to an apparatus with a dispense interface according to the invention and with a drug delivery device, wherein the dispense interface is removably attached to the drug delivery device. | 2015-11-05 |
20150314083 | System, Method, and Apparatus for Detecting Coupling to a Patient Using One or More Electric-Field Sensors - A pump for infusing fluid, the pump including a pumping mechanism, a fluid delivery device, a plurality of electric field sensors, and a measurement component. The plurality of electric field sensors is configured to estimate either an electric field that is associated with a patient, or an electric field that is associated with a fluid path of the pump, or both. The measurement component is configured to receive the electric field estimates from each of the electric field sensors and further configured to measure the difference between the electric field estimates. | 2015-11-05 |