44th week of 2013 patent applcation highlights part 55 |
Patent application number | Title | Published |
20130288894 | METHODS FOR DELAYING MATURITY OF CROPS - Methods for delaying the maturity, coloration and/or senescence of fruits, vegetables, ornamentals, or non-food crops by applying phosphorous acid and/or its salts to the plants; or by applying mixtures of gibberellic acid and/or its salts and phosphorous acid and/or its salts to the plants. Applications may be made pre- or post-harvest at various temperatures and pH ranges. The unique combinations of phosphorous acid/salts with gibberellic acid/salts in embodiments of the present invention have been found to increase the effect of the gibberellic acid/salts on delaying maturation, coloration and senescence of plant tissues, thereby prolonging the shelf life of fruit, vegetables and/or non food crops in ways not previously realized. | 2013-10-31 |
20130288895 | METHODS AND COMPOSITIONS FOR WEED CONTROL - Provided are novel compositions for use in herbicide activity. Specifically, methods and compositions that modulate 5-enolpyruvylshikimate-3-phosphate synthase in plant species. The present invention also provides for combinations of compositions and methods that enhance weed control. | 2013-10-31 |
20130288896 | Uses of thaxtomin and thaxtomin compositions as herbicides - Disclosed is a bacterial secondary metabolite, thaxtomin and optionally another herbicide is an effective herbicide on broadleaved, sedge and grass weeds. Thaxtomin A and structurally similar compounds can be used as natural herbicides to control the germination and growth of weeds in cereal, turf grass, Timothy grass and pasture grass cultures with no phytotoxicity to these crops. | 2013-10-31 |
20130288897 | SYNERGISTIC PESTICIDAL COMPOSITIONS - Synergistic pesticidal compositions including a pesticide/herbicide mixture are provided. | 2013-10-31 |
20130288898 | METHODS AND COMPOSITIONS FOR PROVIDING TOLERANCE TO MULTIPLE HERBICIDES - Methods and compositions are provided related to improved plants that are tolerant to more than one herbicide. Particularly, the invention provides plants that are tolerant of glyphosate and are tolerant to at least one ALS inhibitor, and methods of use thereof. The glyphosate/ALS inhibitor-tolerant plants comprise a polynucleotide that encodes a polypeptide that confers tolerance to glyphosate and a polynucleotide that encodes an ALS inhibitor-tolerant polypeptide. In specific embodiments, a plant of the invention expresses a GAT polypeptide and an HRA polypeptide. Methods to control weeds, improve plant yield, and increase transformation efficiencies are provided. | 2013-10-31 |
20130288899 | SUBSTITUTED PYRIDINES HAVING HERBICIDAL ACTIVITY - The present invention provides substituted pyridine compounds of the formula I | 2013-10-31 |
20130288900 | COMBINATORIAL LIBRARIES OF CONFORMATIONALLY CONSTRAINED POLYPEPTIDE SEQUENCES - The present invention concerns combinatorial libraries of conformationally constrained polypeptide sequences and their uses. In particular, the present invention concerns combinatorial libraries of conformational epitopes and their uses. | 2013-10-31 |
20130288901 | ANALYSIS METHODS - The invention generally relates to methods for analyzing nucleic acids to identify novel mutations associated with diseases. In certain embodiments, methods of the invention involve obtaining nucleic acid from a subject having a disease, identifying at least one mutation in the nucleic acid, and comparing the mutation to a database of mutations known to be associated with the disease, wherein mutations that do not match to the database are identified as novel mutations. | 2013-10-31 |
20130288902 | SYSTEMS AND METHODS FOR PAIRED END SEQUENCING - Systems and methods for analyzing overlapping sequence information can obtain first and second overlapping sequence information for a polynucleotide, align the first and second sequence information, determine a degree of agreement between the first and second sequence information for a location along the polynucleotide, and determine a base call and a quality value for the location. | 2013-10-31 |
20130288903 | Methods For The Diagnosis Of Fetal Abnormalities - The present invention relates to methods for detecting, enriching, and analyzing rare cells that are present in the blood, e.g. fetal cells. The invention further features methods of analyzing rare cell(s) to determine the presence of an abnormality, disease or condition in a subject, e.g. a fetus by analyzing a cellular sample from the subject. | 2013-10-31 |
20130288904 | PHASE-PROTECTING REAGENT FLOW ORDERINGS FOR USE IN SEQUENCING-BY-SYNTHESIS - A method for nucleic acid sequencing includes: disposing a plurality of template polynucleotide strands, sequencing primers, and polymerases in a plurality of defined spaces of a sensor array; exposing template polynucleotide strands to a series of flows of nucleotide species, the series comprising a sequence of random flows; and obtaining, for each of the series of flows of nucleotide species, a signal indicative of how many nucleotide incorporations occurred for that particular flow to determine a predicted sequence of nucleotides corresponding to the template polynucleotide strands. | 2013-10-31 |
20130288905 | METHODS FOR DETECTING MODIFICATION RESISTANT NUCLEIC ACIDS - Methods are provided for, inter alia, detecting nucleic acid molecules resistant to degradation, such as a plurality of RNA molecules bound to a ribosome, using various technologies including deep sequencing. | 2013-10-31 |
20130288906 | DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE - The invention relates to novel variants that associate with Alzheimer's disease AD and their use in kits as a means for diagnosing AD; and also their use in nucleic acid molecules or cells/cell lines for identifying novel therapeutic, label of identification means. | 2013-10-31 |
20130288907 | DNA library, preparation method thereof, and device for detecting SNPs - A DNA library, and a preparing method thereof, a method of determining DNA sequence information, an apparatus and a kit for detecting SNPs, and a method for genotyping may be provided. The method for preparing the DNA library may comprise the steps of: digesting a genomic DNA sample using a restriction endonuclease to obtain a digested product, wherein the restriction endonuclease comprises at least one selected from the group consisting of Mbo II and Tsp 45I; separating the digested product to obtain DNA fragments having a length of 100 bp to 1,000 bp; end-repairing the DNA fragments to obtain an end-repaired DNA fragments; adding a base A to the end of the end-repaired DNA fragments to obtain DNA fragments having a terminal base A; and ligating the DNA fragments having the terminal base A with sequencing adaptors to obtain the DNA library. | 2013-10-31 |
20130288908 | POLYNUCLEOTIDE CONSTRUCT CAPABLE OF DISPLAYING FAB IN A CELL-FREE TRANSLATION SYSTEM, AND METHOD FOR MANUFACTURING AND SCREENING FAB USING SAME - The polynucleotide construct of (1) or (2) below is used to perform ribosome display, CIS display and/or mRNA display in order to screen a Fab against an antigen of interest: (1) a polynucleotide construct which monocistronically comprises a ribosome-binding sequence, Fab first chain-coding sequence, linker peptide-coding sequence, Fab second chain-coding sequence and scaffold-coding sequence in this order, and further comprises at its 3′-end a structure necessary for maintaining a complex with the Fab encoded by itself, and (2) a polynucleotide construct which comprises a Fab first chain-expressing cistron and a Fab second chain-expressing cistron each containing a ribosome-binding sequence, a Fab first chain-coding sequence or Fab second chain-coding sequence, and a scaffold-coding sequence in this order, the first Fab-expressing cistron further comprising at its 3′-end a ribosome stall sequence, said Fab second chain-expressing cistron further comprising at its 3′-end a structure necessary for maintaining a complex with the Fab encoded by itself. | 2013-10-31 |
20130288909 | miRNA DETECTION OF PANCREATIC CANCER - Methods for the diagnosis and/or monitoring of pancreatic cancer by detection of micro-RNAs (miRNA) are provided. In certain embodiments, detection of miR-21, miR-210, miR-155, and/or miR-196a in the plasma, blood, or pancreatic juice of a subject, such as a human patient, may be used to detect, diagnose, or monitor a pancreatic cancer. | 2013-10-31 |
20130288910 | METHODS AND SYSTEMS FOR GENERATING, VALIDATING AND USING MONOCLONAL ANTIBODIES - Provided herein is a library of antibodies, wherein the library of antibodies can comprise a plurality of monoclonal, monospecific, or immunoprecipitating antibodies. Also provided herein is a method for producing and using the library of antibodies. | 2013-10-31 |
20130288911 | FLUOROGENIC HYDRAZINE-SUBSTITUTED COMPOUNDS - The present disclosure is directed to fluorogenic schiff base-forming dyes capable of detecting analytes containing aldehyde and ketone groups. The dyes contain nucleophilic hydrazinyl appendages and are capable of binding and detecting analytes in situ. | 2013-10-31 |
20130288912 | BIOMARKER SIGNATURES AND USES THEREOF - The invention provides a method for determining a Systemic Lupus Erythematosus-associated disease state in a subject comprising the steps of (a) providing a sample to be tested; and (b) measuring the presence and/or amount in the test sample of one or more biomarker(s) selected from the group defined in Table 1, wherein the presence and/or amount in the test sample of the one or more biomarker(s) selected from the group defined in Table 1 is indicative of a Systemic Lupus. The invention also provides an array and a kit suitable for use in the methods of the invention. | 2013-10-31 |
20130288913 | METHOD OF DETERMINING PREDISPOSITION TO SCOLIOSIS - The present invention relates to novel genetic markers associated with scoliosis, risk of developing scoliosis and risk of scoliosis curve progression, and simplified methods and materials for determining whether a human subject has scoliosis, is at risk of developing scoliosis or is at risk of scoliosis curve progression. | 2013-10-31 |
20130288914 | Method Of Determining Administration Effect In Cancer Chemotherapy With S-1 - Provided is a method of determining a therapeutic effect of cancer chemotherapy with an anticancer drug obtained by blending three ingredients, i.e., tegafur, gimeracil, and oteracil potassium as active ingredients (hereinafter abbreviated as S-1) quickly, simply, and accurately before carrying out the cancer chemotherapy. Specifically, provided is a method of determining an administration effect in chemotherapy with S-1, the method comprising: a step (a) of measuring expression level of a decorin gene in a biological sample collected from a subject to be diagnosed; and a step (b) of determining an administration effect of S-1 based on the expression level of the gene obtained from the measurement. | 2013-10-31 |
20130288915 | COMPOSITIONS AND METHODS FOR ALK MOLECULAR TESTING - Disclosed herein are methods of predicting response of a tumor to an ALK inhibitor and methods of determining diagnosis or prognosis of a subject with a tumor. The methods can include detecting presence of an ALK gene fusion (such as EML4-ALK, TFG-ALK, or KIF5B-ALK) in a sample from a subject. Also disclosed herein are arrays for detecting the presence of ALK and/or ROS1 gene fusions in a sample. In some embodiments, the array includes one or more oligonucleotides complementary to an ALK or ROS1 gene fusion. | 2013-10-31 |
20130288916 | REAL-TIME AMPLIFICATION AND MICRO-ARRAY BASED DETECTION OF NUCLEIC ACID TARGETS IN A FLOW CHIP ASSAY - The present method is related to a method for identification and/or quantification of at least one polynucleotide target compound present in a biological sample among possible other ones by its amplification in a cycling flow chip solution passing through different temperatures required for the amplification and its detection in real-time onto a micro-array of specific capture molecules. | 2013-10-31 |
20130288917 | Rapid High Resolution, High Throughput RNA Structure, RNA-Macromolecular Interaction, and RNA-Small Molecule Interaction Mapping - Compositions and methods are provided for a rapid, high-resolution, high-throughput method for determining the intramolecular interactions between the nucleotides present in an polynucleotide, such that single-stranded nucleotides, and nucleotides in a double-stranded configuration are distinguished and identified. Tertiary contacts and solvent accessible regions may also be determined, where such contacts and regions may result from a single stranded configuration, intermolecular interactions with other macromolecules including, without limitation, DNA, protein, RNA, etc.; intermolecular interactions with small molecules which may include drug candidates; or a combination of macromolecules and small molecules. | 2013-10-31 |
20130288918 | Colorectal Cancer Screening Method - The invention relates to a method of screening for colorectal cancer in a subject, comprising a step of measuring the degree of methylation of at least one of the genes selected from NPY, PENK and fragments or variants thereof in a biological sample obtained from said subject. | 2013-10-31 |
20130288919 | LABEL-FREE MOLECULE DETECTION AND MEASUREMENT - A system and method for electrically detecting a target material in a sample without the need for labeling is described. A probe supporting member defining at least one hole is functionalized with target specific probe material and a change in the hole area on binding of target material is detected as a change in an ionic current through the hole. In some embodiments, an electro-chemical cell comprising an electrode having a conducting layer and a porous insulating layer is provided. In some embodiments, an electrically addressable array is provided for detection of a potentially large number of target materials in a sample. | 2013-10-31 |
20130288920 | MULTIANALYTE MOLECULAR ANALYSIS USING APPLICATION-SPECIFIC RANDOM PARTICLE ARRAYS - The present invention provides a method for the generation of novel libraries of encoded magnetic particles from sub-libraries of by the generation of novel sub-libraries of magnetic nanoparticles and encoded particles. The sub-libraries are functionalized on demand are useful in the formation of arrays. The present invention is especially useful for performing multiplexed (parallel) assays for qualitative and/or quantitative analysis of binding interations of a number of analyte molecules in a sample. | 2013-10-31 |
20130288921 | MUTATED PARVOVIRUS STRUCTURAL PROTEINS AS VACCINES - The present invention is related to a method for identifying a parvovirus mutated structural protein capable of specifically binding to a binder for an antigen, a parvovirus mutated structural protein which comprises at least one B-cell epitope heterologous to the parvovirus, a multimeric structure comprising the protein, a nucleic acid encoding the protein, a virus or cell comprising the protein, a method of preparing the protein, a medicament comprising the protein, nucleic acid or multimeric structure and its use. | 2013-10-31 |
20130288922 | ARRAYED DETECTOR SYSTEM FOR MEASUREMENT OF INFLUENZA IMMUNE RESPONSE - A sensor chip for detecting an immune response against an influenza virus, the sensor chip including a substrate having a surface and a plurality of hemagglutinin polypeptides bound to discrete locations on the surface of the substrate, each hemagglutinin polypeptide having a hemagglutinin epitope. Detection devices containing the sensor chip and methods of detecting influenza immune responses are also described herein. | 2013-10-31 |
20130288923 | Nucleotide-Based Probes and Methods for the Detection and Quantification of Macromolecules and Other Analytes - Provided are unimolecular oligonucleotide probes for detecting a target in a sample. The probes use target binding-induced structural changes to detect the presence of the target in the sample. Also provided are methods of using the probes to detect a target in a sample. | 2013-10-31 |
20130288924 | METHOD FOR DIAGNOSING HEMATOLOGICAL DISORDERS - Disclosed is a method for the diagnosis, and/or the classification, of a hematological disorder, including the steps of: a). measuring, the expression level of at least the genes of a sub-group of 6 genes, b). comparing the expression level of each genes measured in step a)., with the expression level of the same genes in healthy control sample, and c). determining the status of the biological sample. | 2013-10-31 |
20130288925 | PRODUCTION OF NUCLEIC ACID - A method for the production of nucleic acid encoding a target protein. The method comprises (a) providing an array of RNA or DNA molecules including one or more encoding the target protein; (b) generating a target protein from the array to form RNA-protein or DNA-protein complexes in which the RNA or DNA molecule is non-covalently or covalently bound to the complex; (c) separating the complexes into compartments wherein most or all of the compartments contain no more than one complex; (d) subjecting the complexes to reaction conditions which allow target protein activity; and (e) selecting nucleic acid encoding the target protein on the basis of the activity associated therewith, wherein when the complex is a DNA-protein complex in which the DNA is non-covalently bound, step b) is performed in the absence of separate compartments for each complex. | 2013-10-31 |
20130288926 | METHODS OF GENERATING AND SCREENING FOR LYTIC CHIMERIC POLYPEPTIDES - The present invention relates to novel methods of generating and screening for chimeric polypeptides, which can be used in the treatment and prophylaxis of pathogenic bacterial contamination, colonisation and infection. The novel methods are based on random recombination of protein domains, and the chimeric polypeptides obtainable by the methods according to the invention are characterized in that they comprise at least one enzymatic active domain (EAD) and at least one cell binding domain (CBD). The present invention also relates to a library of chimeric polypeptides obtainable by the methods of the present invention. | 2013-10-31 |
20130288927 | Fusion Proteins to Facilitate Selection of Cells Infected with Specific Immunoglobulin Gene Recombinant Vaccinia Virus - The present invention relates to a high efficiency method of expressing immunoglobulin molecules in eukaryotic cells. The invention is further drawn to a method of producing immunoglobulin heavy and light chain libraries, particularly using the trimolecular recombination method, for expression in eukaryotic cells. The invention further provides methods of selecting and screening for antigen-specific immunoglobulin molecules, and antigen-specific fragments thereof. The invention also provides kits for producing, screening and selecting antigen-specific immunoglobulin molecules. Finally, the invention provides immunoglobulin molecules, and antigen-specific fragments thereof, produced by the methods provided herein. | 2013-10-31 |
20130288928 | GLYCAN ARRAYS AND METHODS FOR THEIR FABRICATION - The invention relates to glycan arrays with quantified levels of glycan expression and a method for fabricating thereof. The method comprises quantitatively reacting an ω-aminoalkylglycan with an activated polymer of an acrylic acid derivative to obtain glycoconjugated polymer or copolymer and covalently attaching the (co)polymer to a functionalized substrate. The glycan arrays according to the invention comprise an co-aminoalkylglycan covalently attached to a functionalized substrate via a fluorescently labeled (co)polymer of an acrylic acid derivative. The copolymer of an acrylic acid derivative may comprise fluorescein cadaverine as a fluorescent label or lysine or aminated PEG. The functionalized substrate is selected from an epoxylated and aminated glass or plastic. The invention also provides a fluorescently labeled co-aminoalkylglycan conjugated polymer of an acrylic acid derivative for use in the fabrication of glycan arrays. | 2013-10-31 |
20130288929 | Method for Making an Enriched Library - A method for making an enriched library comprising specific nucleic acid sequence information allowing to identifying at least one binding entity that binds to at least one target wherein the specific binding entity has been present in an in vitro display library. | 2013-10-31 |
20130288930 | EFFICIENT METHOD FOR DISPLAYING PROTEIN MULTIMER - The invention provides a method of producing a protein multimer-nucleic acid complex comprising a protein multimer and any one target component of the protein multimer. A nucleic acid encoding the target component is subjected to in vitro translation to provide a translation product containing a target component-nucleic acid complex of the target component and the nucleic acid encoding the target component. A nucleic acid encoding a non-target component constituting the protein multimer together with the target component is translated into the non-target component by adding the nucleic acid encoding the non-target component to the previously provided translation product to provide the non-target component. The non-target component then is associated with the target component contained in the target component-nucleic acid complex to form a protein multimer, thus affording the protein multimer-nucleic acid complex of the protein multimer and the nucleic acid encoding the target component. | 2013-10-31 |
20130288931 | INDEPENDENTLY REMOVABLE NUCLEIC ACID SEQUENCING SYSTEM AND METHOD - A system for sequencing nucleic acids, that includes (a) a table having an arrangement of sites, including a site for receiving a first substrate, and a site for receiving a second substrate, the substrates each having an array for providing sequencing data for a plurality of different nucleic acids in parallel; (b) a plurality of stations configured to carry out manipulations in a sequencing procedure; and (c) a system control interface configured to direct relative movement between the table and the plurality of stations, and to direct different steps of the sequencing procedure to occur at the sites for receiving the different substrates, wherein the first substrate can be removed from the system independently of the second substrate such that the second substrate can be processed to obtain sequencing data independently of the first substrate. | 2013-10-31 |
20130288932 | METHODS OF CRYODESICCATING A BROTH COMPRISING A BIOPOLYMER OF AN EXOPOLYSACCHARIDE - According to an embodiment, a method of providing a biopolymer comprises: cryodesiccating a broth, wherein the broth comprises: (A) a biopolymer, wherein the biopolymer is an exopolysaccharide; and (B) a liquid growth medium. According to certain embodiments, the biopolymer is produced by the fermentation of at least one carbohydrate via a microbe. According to an embodiment, the microbe is a bacterium. According to another embodiment, the microbe is a fungus. | 2013-10-31 |
20130288933 | Rheology Modifiers - A non-aqueous wellbore servicing fluid comprising a rheology modifier wherein the rheology modifier comprises a reaction product of a polysulfide, a dimer acid and a polyfunctional amine. A method of conducting an oilfield operation comprising placing an oil-based mud comprising a rheology modifier into a wellbore wherein the rheology modifier comprises a reaction product of a polysulfide, a dimer acid and a polyfunctional amine. | 2013-10-31 |
20130288934 | Composite Solids System to Prepare Polymer Solutions for Hydraulic Fracturing Treatments - A method of reducing the cost and environmental impact of chemicals used in hydraulic fracturing is to use multiple chemicals that are pre-mixed and then formed into a single solid blended mixture. By forming at least two chemicals into a single solid mixture, the complexity involved in transporting multiple solid or liquid chemicals is avoided. If the solid chemicals were merely premixed they would tend to segregate during shipping, handling, and storage altering the concentration of the chemical mix as it is pumped downhole. Simply having less equipment on the wellsite increases the accuracy of the well treating process and decreases the likelihood of a time consuming and thus costly delay due to equipment failure. | 2013-10-31 |
20130288935 | COMPOSITIONS AND METHODS USEFUL FOR OIL EXTRACTION - The present invention relates to compositions comprising a plant material, and methods for using the same in extracting or removing a hydrocarbon-containing substance from a substrate or remediating a substrate. | 2013-10-31 |
20130288936 | NANOSTRUCTURE OF A REVITALIZING AGENT AND METHOD FOR PRODUCING A STABLE FORM OF A NANOSTRUCTURE OF A REVITALIZING AGENT - The invention relates to the production of materials which can be used in lubricating compositions for treating friction assemblies and also for restoring the friction surfaces of mechanism and machine parts. | 2013-10-31 |
20130288937 | ADDITIVES FOR FUELS AND LUBRICANTS - An additive compound comprising a derivative of particular fatty acids and polyamines has been found to be friction reducing, and particularly readily miscible in fuels and lubricants. The fatty acid has more than 12 carbon atoms and at least one carboxylic group. The polyamine residue has more than two nitrogen atoms. The mole ratio of the carboxylic groups to nitrogen atoms used to form the compound is greater than 0.8 carboxylic groups per 1 nitrogen atom. | 2013-10-31 |
20130288938 | Lubricating Oil Composition - A crankcase lubricating oil composition comprising (A) an oil of lubricating viscosity in a major amount; and (B) an additive component in a minor amount comprising one or more oil-soluble sterically unhindered meta-hydrocarbyl substituted phenols. | 2013-10-31 |
20130288939 | NON-AROMATIC BASED ANTIOXIDANTS FOR LUBRICANTS - A lubricant composition comprises a cycloaliphatic amine alkoxylate and a base oil selected from (a) a polyalkylene glycol; (b) a polyalphaolefin; (c) a naphthenic compound; and (d) combinations thereof; provided that the cycloaliphatic amine alkoxylate and the base oil are miscible. The lubricant may exhibit a viscosity change at 40° C. of less than 5 percent (%) after 13 days at 120° C. in dry air, indicating significant thermoxidative stability with minimal or no aromatic content, thereby enabling use of Groups II and III base oils, in particular, without reduced toxicity and/or quality concerns as compared with Group I base oil lubricants. | 2013-10-31 |
20130288940 | PERFUME COMPOSITION COMPRISING FRAGRANCE ALDEHYDE OR KETONE AND OXAZOLIDINE FRAGRANCE PRECURSOR - The invention relates to perfume compositions encompassing fragrance aldehyde or fragrance ketone, and to an oxazolidine fragrance precursor, corresponding thereto, that can release the same fragrance aldehyde or the same fragrance ketone. The perfume compositions can be incorporated in stable fashion into consumer products such as, for example, washing agents, and enable both efficient product scenting and long-lasting item scenting, in particular of textiles. | 2013-10-31 |
20130288941 | FORMULATIONS, THEIR USE AS OR FOR PRODUCING DISHWASHING COMPOSITIONS AND THEIR PREPARATION - The present invention relates to formulations comprising
| 2013-10-31 |
20130288942 | LAUNDRY DETERGENT COMPOSITION COMPRISING PARTICLES OF PHTHALOCYANINE COMPOUND - The present invention relates to encapsulated phthalocyanine particles, to a process for the preparation thereof, compositions comprising such particles and washing agent formulations. | 2013-10-31 |
20130288943 | LAUNDRY DETERGENT PARTICLE - The present invention provides a coated lenticular or disc detergent particle having perpendicular dimensions x, y and z, wherein x is from 1 to 2 mm, y is from 2 to 8 mm and z is from 2 to 8 mm, wherein the particle comprises: (i) from 40 to 90 wt % surfactant selected from anionic surfactant and non-ionic surfactant; (ii) from 1 to 40 wt % water soluble inorganic salts; and (iii) from 0.0001 to 0.1 wt % pigment, wherein the pigment is selected from organic and inorganic pigments, wherein the inorganic salts are present on the detergent particle as a coating and the surfactant and the pigment are present as a core. | 2013-10-31 |
20130288944 | LIQUID COMPOSITION COMPRISING ETHYLENEDIAMINE DISUCCINIC ACID SALT - A liquid composition comprising 1-hydroxyethylidene-1,1-diphosphonic acid and a salt of ethylenediamine disuccinic acid which salt includes a counterion selected from 5 potassium, rubidium, caesium a substituted ammonium ion or mixtures thereof. | 2013-10-31 |
20130288945 | ABRASIVE CLEANING AGENT, METHOD FOR MANUFACTURING THE SAME, AND METHOD FOR POLISHING USING ABRASIVE CLEANING AGENT - An abrasive cleaning agent is provided which can be used for a polishing process for polishing a surface of a workpiece to form a mirror surface, which suppresses generation of static electricity and adhesion of stains to the workpiece, which decreases a crushing ratio, and which has a low environmental burden when the abrasive cleaning agent is disposed of. The above abrasive cleaning agent includes an elastic material containing a soluble nitrogen substance as a primary component, which is obtained from tubers of devil's tongue and which contains mannan as a primary component, and a 10% to 30% of water; and 1 to 30 percent by weight, with respect to the elastic material, of abrasive grains of size #220 or less, which are supported on surfaces of the elastic material and/or are buried therein, so that the grain diameter on the whole is in the range of 88 to 1,190 μm. | 2013-10-31 |
20130288946 | LIGHT-DUTY LIQUID DETERGENTS BASED ON COMPOSITIONS DERIVED FROM NATURAL OIL METATHESIS - Light-duty liquid detergents derived from metathesized natural oil feedstocks are disclosed. The detergents comprise water, at least one anionic surfactant, and at least one secondary surfactant derived from a metathesis-derived C | 2013-10-31 |
20130288947 | BENZODIOXOLE DERIVATIVES AS WATERY ODORANTS - The present invention relates to compounds of formula (I) in the form of any one of its stereoisomers or a mixture thereof, and wherein R | 2013-10-31 |
20130288948 | ESTABLISHMENT OF MOTIF COMPRISING ACIDIC AMINO ACID, CAPABLE OF STABILIZING PROTEIN IN CELLS, AND APPLICABLE TO PROTEIN THERAPY, CONTROL OF DIFFERENTIATION/UNDIFFERENTIATION OF CELL AND ANTIBODY THERAPY - A motif is searched which can inhibit the proteolysis of a protein that has been administered to a cell or an individual. Thus, disclosed is a method for designing/producing a protein having resistance to proteolysis. Specifically disclosed is a motif capable of inhibiting proteolysis, which comprises an amino acid region lying between the 396 | 2013-10-31 |
20130288949 | COMPOSITIONS FOR OXYGEN TRANSPORT COMPRISING A HIGH OXYGEN AFFINITY MODIFIED HEMOGLOBIN - The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have better stability to auto oxidation and superior oxygen carrying characteristics. | 2013-10-31 |
20130288950 | USE OF TIGHT JUNCTION ANTAGONISTS IN THE TREATMENT OF ACUTE LUNG INJURY AND ACUTE RESPIRATORY DISTRESS - The present application provides compositions and methods for treating acute lung injury and acute respiratory distress syndrome. The methods include administering one or more tight junction antagonists to the lung of a subject in need thereof. | 2013-10-31 |
20130288951 | COMPOSITIONS AND METHODS FOR COATING IMPLANT SURFACES TO INHIBIT SURGICAL INFECTIONS - Infection-inhibiting compositions suitable for coating surfaces of implantable medical implants, including compositions and devices for coating medical devices in the operating room prior to implantation in a patient. Methods for inhibiting infection at the site of implantation of an orthopedic device in a human or animal subject, comprise rubbing a surface of the device, prior to implantation, with an infection-inhibiting composition having a waxy matrix comprising an infection-inhibiting material selected from the group consisting of a lipid, an antimicrobial agent, and mixtures thereof, wherein a thin layer of the infection-inhibiting material is deposited on the surface of the device. Medical implants which may be treated in the methods of this technology include orthopedic implants. Lipids include long-chain diacylglycerides or triacylglycerides, which may be saturated or unsaturated, such as lecithin or a purified form of phosphatidylcholine. | 2013-10-31 |
20130288952 | Polypeptides and Immunizing Compositions Containing Gram Positive Polypeptides and Methods of Use - The present invention provides isolated polypeptides isolatable from a | 2013-10-31 |
20130288953 | USE OF A COMPOSITION COMPRISING AN ANTIMICROBIAL PEPTIDE AS A FOOD PRESERVATIVEUSE OF A COMPOSITION COMPRISING AN ANTIMICROBIAL PEPTIDE AS A FOOD PRESERVATIVE - The inventors provide the use of a composition comprising an antimicrobial polypeptide comprising Blad or an active variant thereof to prevent or inhibit spoilage of a foodstuff by a microorganism. Also provided is a method of preventing or inhibiting spoilage of a foodstuff by a microorganism comprising administering to a foodstuff in need thereof an effective amount of a composition comprising an antimicrobial polypeptide comprising Blad or an active variant thereof. | 2013-10-31 |
20130288954 | USE OF CHELATING AGENT AND PEPTIDE ANTIMICROBIAL COMPOUNDS - The inventors provide the use of a chelating agent and an antimicrobial agent that is effective against a plant pathogenic microorganism to inhibit the growth of and/or kill a plant pathogenic microorganism on a plant; the use of a chelating agent to increase the activity of an antimicrobial that is effective against a plant pathogenic microorganism; a method of inhibiting the growth of and/or killing a plant pathogenic microorganism comprising administering to a plant in need thereof a chelating agent and an antimicrobial agent that is effective against a plant pathogenic microorganism; and a method of increasing the activity of an antimicrobial that is effective against a plant pathogenic microorganism comprising using said antimicrobial with a chelating agent. Also provided is a composition comprising a chelating agent and an antimicrobial agent that is effective against a plant pathogenic microorganism, use of said composition to inhibit the a growth of and/or kill a plant pathogenic microorganism on a plant, and a method of inhibiting the growth of and/or killing a plant pathogenic microorganism comprising administering to a plant in need thereof said composition. Further provided is the use of a composition comprising an antimicrobial polypeptide comprising Blad or an active variant thereof to kill, or inhibit the growth of a plant pathogenic bacterium on a plant, and a method of killing, or inhibiting the growth of a plant pathogenic bacterium on a plant, said method comprising administering to said plant a composition comprising an effective amount of an antimicrobial polypeptide comprising Blad or an active variant thereof. | 2013-10-31 |
20130288955 | STRUCTURAL AND MECHANISTIC BASIS FOR NOVEL COMPOUND BIOSYNTHESIS USING 4-ELECTRON HEXOSE OXIDASE - A novel pharmaceutical composition comprising a compound of formula (I) is disclosed. The novel compound can include a pharmaceutically acceptable carrier. The invention further comprises methods for making compounds of formula (I) using Dbv29, and to the use of compound of formula (I) to treat bacterial infections. | 2013-10-31 |
20130288956 | COMBINED PHARMACEUTICAL COMPOSITION AS ANTIFUNGAL AGENT - An object of the present invention is to provide a pharmaceutical composition having superior antifungal activity. The present invention provides a pharmaceutical composition comprising 3-(3-(4-(pyridin-2-yloxymethyl)-benzyl)-isoxazol-5-yl)-pyridin-2-ylamine or 2-amino-1-((phosphonooxy)methyl)-3-(3-((4-((2-pyridinyloxy)methyl)phenyl)methyl)-5-isoxazolyl)-pyridinium or a salt thereof in combination with an antifungal agent. | 2013-10-31 |
20130288957 | ORAL COMBINATION THERAPY FOR TREATING HCV INFECTION IN SPECIFIC PATIENT SUBGENOTYPE POPULATIONS - The present invention relates to therapeutic combinations comprising (a) Compound (1), or a pharmaceutically acceptable salt thereof, as herein described, (b) Compound (2), or a pharmaceutically acceptable salt thereof, as herein described, and optionally (c) ribavirin, and methods of using such therapeutic combinations for treating HCV infection or alleviating one or more symptoms thereof in a patient that has genetic variations located near the IL28B gene, including SNP rs12979860 with a CC or non-CC genotype and SNP rs8099917 with a TT or non-TT genotype. | 2013-10-31 |
20130288958 | Novel Glucagon Analogues - The present invention relates to novel glucagon peptides, to the use of said glucagon peptides in therapy, to methods of treatment comprising administration of said glucagon peptides to patients in need thereof, and to the use of said glucagon peptides in the manufacture of medicaments. The glucagon peptides of the present invention are of particular interest in relation to the treatment of hyperglycemia, diabetes and obesity, as well as a variety of diseases or conditions associated with hyperglycemia, diabetes and obesity. | 2013-10-31 |
20130288959 | SCREENING METHOD FOR ANTIDIABETIC AGENT USING NEWLY IDENTIFIED INSULIN SECRETION REGULATION FACTOR - It is an object of the present invention to provide a newly identified insulin secretion regulation factor that can control blood sugar in the normal range, and a method for screening an antidiabetic drug using said factor. | 2013-10-31 |
20130288960 | Double-Acylated GLP-1 Derivatives - The invention relates to a derivative of a GLP-1 analogue, which analogue comprises a first K residue at a position corresponding to position 18 of GLP-1 (7-37) (SEQ ID NO: 1), a second K residue at another position, and a maximum of twelve amino acid changes as compared to GLP-1 (7-37); which derivative comprises two protracting moieties attached to said first and second K residue, respectively, via a linker, wherein the protracting moiety is selected from Chem. 1, Chem. 2, and Chem. 3: Chem.: HOOC—(CH | 2013-10-31 |
20130288961 | METHODS FOR TREATING STEATOTIC DISEASE - Methods for treating fatty liver disease, e.g., hepatic steatosis, using peptide fragments of the C-terminal end of glucagon-like peptide-1 (GLP-1), e.g., GLP-1(28-36). | 2013-10-31 |
20130288962 | METHODS AND COMPOSITIONS FOR THE REPAIR AND/OR REGENERATION OF DAMAGED MYOCARDIUM - Methods, compositions, and kits for repairing damaged myocardium and/or myocardial cells including the administration cytokines are disclosed and claimed. Methods and compositions for the development of large arteries and vessels are also disclosed and claimed. The present application also discloses and claims methods and media for the growth, expansion, and activation of human cardiac stem cells. | 2013-10-31 |
20130288963 | ANTICANCER FUSION PROTEIN - A fusion protein comprising domain (a) which is a functional fragment of hTRAIL protein sequence, which fragment begins with an amino acid at a position not lower than hTRAIL95, or a homolog of said functional fragment having at least 70% sequence identity; and domain (b) which is a sequence of an anti-angiogenic effector peptide, wherein the sequence of domain (b) is attached at the C-terminus or N-terminus of domain (a). The fusion protein can be used for the treatment of cancer diseases. | 2013-10-31 |
20130288964 | Use of peptides for promoting wound healing - The current invention relates to the use of a peptide comprising an amino acid sequence in the preparation of a medicament for the regeneration of tissue, preferably for the treatment of a wound. Further the invention relates to compositions comprising such peptides, and use of said peptides in both medical and nonmedical (cosmetic) applications. | 2013-10-31 |
20130288965 | Use of peptides for promoting wound healing - The current invention relates to the use of a peptide comprising an amino acid sequence in the preparation of a medicament for the regeneration of tissue, preferably for the treatment of a wound. Further the invention relates to compositions comprising such peptides, and use of said peptides in both medical and nonmedical (cosmetic) applications. | 2013-10-31 |
20130288966 | Peripheral Administration of Proteins Including TGF-beta Superfamily Members for Treatment of Systemic Disorders and Disease - The present invention is directed to methods and compositions for accomplishing systemic delivery of minimally-soluble bioactive agents such as, but not limited to, proteins of the TGF-β superfamily via a peripheral mode of administration. According to the invention, an exemplary bioactive agent is BMP-7. The invention further provides for minimally-invasive systemic treatment of skeletal disorders such as osteoporosis as well as minimally-invasive systemic treatment of injured or diseased non-mineralized tissues and organs such kidneys. Practice of the invention eliminates adverse side effects at the peripheral site of intravenous administration of the bioactive agent. | 2013-10-31 |
20130288967 | MATERIALS AND METHODS FOR CANCER DIAGNOSIS BY EVALUATION OF THE METHYLATION STATUS OF CPG ISLANDS ON CHROMOSOMES 6 AND 8 - Provided are methods, reagents, and kits for evaluating cancer, such as prostate cancer, in a subject. Disclosed methods of evaluating cancer include methods of diagnosing cancer, methods of prognosticating cancer and methods of assessing the efficacy of cancer treatment. The methods include assaying a biological sample for methylation of a CpG island associated with specified genes. Provided reagents and kits include primers suitable for amplifying at least a portion of a target CpG islands associated with specified genes. | 2013-10-31 |
20130288968 | LEUPROLIDE INJECTION - The present invention provides a sterile solution comprising leuprolide acetate in a pharmaceutically acceptable vehicle, wherein solution is present as a reservoir in a multiple dose pen injection device, the device being adapted to subcutaneously inject a portion of the said reservoir in a single daily dose and further being adapted to provide multiple portions of solution said while the reservoir remains sterile. | 2013-10-31 |
20130288969 | PARATHYROID HORMONE RECEPTOR ACTIVATION AND STEM AND PROGENITOR CELL EXPANSION - The invention relates to methods for manipulating hematopoietic stem or progenitor cells, mesenchymal stem cells, epithelial stem cells, neural stem cells and related products through activation of the PTH/PTHrP receptor in neighboring cells. | 2013-10-31 |
20130288970 | COMPOSITIONS AND METHODS FOR THE DELIVERY OF OXYGEN - H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas O | 2013-10-31 |
20130288971 | SHORT PEPTIDES FOR ENHANCING MUSCLE FUNCTION - The present invention relates to shortened peptides comprising a muscle function enhancing amino acid sequence which is derived from the S100 calcium binding protein family. Furthermore, the present invention provides said peptides for medical use, in particular, for treating or preventing disorders associated with muscular malfunction, such as skeletal muscle or cardiac muscle disorders. The present invention also provides a pharmaceutical compositions comprising said peptides and a method for treating or preventing disorders associated with muscular malfunction using said peptides or said pharmaceutical compositions. | 2013-10-31 |
20130288972 | Compositions and Methods For The Treatment of Orthopedic Disease or Injury - Methods for reducing the severity of an arthritic condition or repairing an osteochondral defect are carried out by administering to a subject compositions comprising a member of the matrilin family of proteins, e.g., a matrilin protein, fragment thereof, or nucleic acid encoding the protein or fragment. | 2013-10-31 |
20130288973 | Decellularized small particle tissue - A process for producing a decellularized small particle tissue which involves selecting an appropriate tissue starting material from which a decellularized small particle tissue is desired to be prepared, treating the tissue with a decellularizing agent at an acid pH to remove at least a portion of the cellular material therefrom and to yield a product comprising a liquid component and a solid component, subjecting the liquid component and the solid component to a plurality of filters, F | 2013-10-31 |
20130288974 | METHOD FOR AMELIORATING PAIN BY MODIFICATION OF NMDA RECEPTORS THROUGH INHIBITION OF SRC - The present invention provides a method for ameliorating inflammatory and/or neuropathic pain in a subject by modifying the activity of N-methyl-D-aspartate (NMDA) receptors in cells of the subject by inhibition of the interaction of the unique domain of the tyrosine kinase Src enzyme and the NMDA receptor complex. | 2013-10-31 |
20130288975 | Methods of Treating Depression and Other Related Diseases - The invention relates to methods for treating depression, anxiety, and other related diseases by administering a peptide NMDAR partial agonist. | 2013-10-31 |
20130288976 | Methods for Determining the Presence or Risk of Developing Facioscapulohumeral Dystrophy (FSHD) - In one aspect, the invention provides a method of screening a human subject to determine if said subject has a genetic predisposition to develop, or is suffering from Facioscapulohumeral Dystrophy (FSHD), said method comprising: (a) providing a biological sample comprising genomic DNA from the subject; and (b) analyzing the portion of the genomic DNA in the sample corresponding to the distal D4Z4-pLAM region on chromosome 4 and determining the presence or absence of a polymorphism resulting in a functional polyadenylation sequence operationally linked to exon 3 of the DUX4 gene, wherein a determination of the absence of a functional polyadenylation sequence operationally linked to exon 3 of the DUX4 gene indicates that the subject does not have a genetic predisposition to develop, and is not suffering from FSHD, and/or wherein a determination of the presence of a functional polyadenylation sequence operationally linked to exon 3 of the DUX4 gene indicates that the subject has a genetic predisposition to develop, or is suffering from Facioscapulohumeral Dystrophy (FSHD). | 2013-10-31 |
20130288977 | METHOD OF REGULATING NEURONAL AXON ELONGATION - The present invention includes a treating step of treating neuronal growth cone with a regulatory factor to regulate macropinocytosis caused by a repulsive axon guidance molecule. The present invention can provide a new neuronal axon elongation regulating method etc. | 2013-10-31 |
20130288978 | DERMATOPONTIN-ACTIVATING PEPTIDES AND COSMETIC COMPOSITIONS INCLUDING SAME - This invention relates to peptides activating dermatopontin in the skin. | 2013-10-31 |
20130288979 | Inhibitors of Apoptosis and Uses Thereof - The invention relates to fragments of the DAXX and FADD proteins that inhibit cell apoptosis, in particular cell apoptosis mediated by the Fas receptor. The invention also relates to derivatives of said anti-apoptotic fragments, conjugates comprising said fragments, pharmaceutical compositions comprising said fragments, and to the medical applications of said fragments, derivatives, conjugates, and pharmaceutical compositions thereof in the treatment or prevention of diseases and conditions associated with apoptosis. | 2013-10-31 |
20130288980 | TARGETING SENESCENT AND CANCER CELLS FOR SELECTIVE KILLING BY INTERFERENCE WITH FOXO4 - The present invention relates to agents that inhibit FOXO4 function and uses thereof in treating cancer and/or removing senescent cells in an individual. | 2013-10-31 |
20130288981 | TARGETING SENESCENT CELLS AND CANCER CELLS BY INTERFERENCE WITH JNK AND/OR FOXO4 - The present invention relates to uses of agents that inhibit Jun kinases and/or FOXO4 in treating cancer and/or removing senescent cells in an individual. | 2013-10-31 |
20130288982 | THERAPEUTIC AGENT FOR PULMONARY SMALL CELL CARCINOMA - The invention aims to clarify further functions of a T-cell leukemia translocation-associated gene (TCTA) protein-derived peptide and provide a novel application of the peptide. The invention provides a therapeutic agent for pulmonary small cell carcinoma or a cell growth inhibitor of pulmonary small cell carcinoma, comprising any peptide described in SEQ ID NOs 1 to 5. | 2013-10-31 |
20130288983 | VARIANT ACTIVIN RECEPTOR POLYPEPTIDES AND USES THEREOF - The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided. | 2013-10-31 |
20130288984 | COMBINATION - The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering a proteasome inhibiting compound, and N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide, or a pharmaceutically acceptable salt thereof, and optional additional antineoplastic agents, to a human in need thereof. | 2013-10-31 |
20130288985 | COMPOSITIONS AND METHODS OF TREATMENT OF CORNEAL ENDOTHELIUM DISORDERS - This application discloses pharmaceutical compositions (e.g., oral, parenteral or topical ophthalmic formulations) for treating Fuchs endothelial corneal dystrophy (FECD) with one or more Nrf2 activators and/or mitochondrially targeted antioxidants. The compositions may be topically administered to the eye and are effective in the treatment of FECD. The invention further provides methods of treating FECD by in a subject in need of such treatment by topical application of one or more Nrf2 activators and/or mitochondrially of the invention. | 2013-10-31 |
20130288986 | POLYMER DRUG CONJUGATES WITH TETHER GROUPS FOR CONTROLLED DRUG DELIVERY - Described herein is a cyclodextrin containing polymer conjugate. | 2013-10-31 |
20130288988 | Diagnostic Methods and Markers for Bacterial Vaginosis - A method of diagnosing bacterial vaginosis in a woman, which involves determining an amount of each of more than one BV-associated bacterium in a vaginal sample obtained from the female and assessing a BV status of the female based on the amount of each of the more than one BV-associated bacterium in the sample. | 2013-10-31 |
20130288989 | NEW USE OF CHEMICAL INGREDIENTS IN CYNOMORIUM AS PHYTOESTROGEN - Use of chemical ingredients in | 2013-10-31 |
20130288990 | CONTROLLING PESTS BY COMBINING INSECTICIDES AND TRANSGENIC PLANTS BY APPLYING DIRECTLY TO LEAVES AND ROOTS - The invention relates to a method for controlling pests using a combination of insecticides and transgenic plants and consequently improving the utilization of the production potential of transgenic plants which comprises treating the plant with active compound combinations comprising an active compound from the group of the anthranilamides and at least one further insecticide. | 2013-10-31 |
20130288991 | BLOCK COPOLYMERS FOR STABLE MICELLES - The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same. Compositions herein are useful for drug-delivery applications. | 2013-10-31 |
20130288992 | GLYCOSIDE COMPOUND - Compounds of formula (I″) | 2013-10-31 |
20130288993 | METHOD FOR DIAGNOSIS AND METHOD OF TREATMENT OF AUTISM SPECTRUM DISORDERS AND INTELLECTUAL DISABILITY - We provide a set of novel mutations in HIST3H3, AMT, GLDC and PEX7 genes which we have discovered as causative of some autism spectrum disorders and/or intellectual disability after analysis of families with more than one affected child and with consanguineous parents. Based on some of these mutations, we also provide novel treatment options for autism spectrum disorders and/or intellectual disability wherein the novel mutations have been diagnosed. The invention is based on the discovery that certain specific mutations, particularly when present in a homozygous, compound heterozygous, or trans heterozygous combinations, result in a phenotype of an autism spectrum disorder and/or intellectual disability. Some mutations also cause the disorder or disease as heterozygous mutation. | 2013-10-31 |
20130288994 | READY TO BE INFUSED GEMCETABINE SOLUTION - A large volume infusion dosage form of gemcitabine, comprising a stable large volume solution of gemcitabine or its pharmaceutically acceptable salt in an aqueous vehicle filled in a large volume infusion container, wherein the solution is ready-to-be-infused. | 2013-10-31 |