44th week of 2014 patent applcation highlights part 58 |
Patent application number | Title | Published |
20140323529 | OLIGOMER-CALCIUM CHANNEL BLOCKER CONJUGATES - The invention provides small molecule drugs that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the small molecule drug not attached to the water soluble oligomer. | 2014-10-30 |
20140323530 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS - Provided are amine derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions. | 2014-10-30 |
20140323531 | HDAC INHIBITORS - Compounds of formula (I) inhibit HDAC activity: | 2014-10-30 |
20140323532 | AMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF - Compounds are provided according to formula 1: | 2014-10-30 |
20140323533 | COMBINATION OF ANTI-CTLA4 ANTIBODY WITH TUBULIN MODULATING AGENTS FOR THE TREATMENT OF PROLIFERATIVE DISEASES - Compositions and methods are disclosed which are useful of the treatment and prevention of proliferative disorders. | 2014-10-30 |
20140323534 | USES OF 3'-DESFERRITHIOCIN ANALOGS - Macular degeneration, closed head injury, stroke, irritable bowel disease, and reperfusion injury are all associated with biological injury due to reactive oxygen species, probably due to focal iron overload in many instances. The present invention provides methods and pharmaceutical compositions for treating these diseases and conditions using desferrithiocin analogs of Formula (I). In certain embodiments, the analogs include a polyether moiety at the 3′-position of the phenyl ring of the compound. Formula (I). | 2014-10-30 |
20140323535 | 5-OXO-ETE RECEPTOR ANTAGONIST COMPOUNDS - The present invention relates to novel pharmaceutically-useful compounds which are antagonists of the 5-oxo-ETE receptors, such as the OXE receptor. These compounds have use as therapeutic and/or prophylactic agents for diseases characterized by tissue eosinophilia, such as inflammatory conditions including respiratory diseases. The invention also relates to pharmaceutical compositions, to the use of such compounds and compositions as medicaments, and to therapeutic methods. | 2014-10-30 |
20140323536 | TREATMENT OF ARTERIAL WALL BY COMBINATION OF RAAS INHIBITOR AND HMG-CoA REDUCTASE INHIBITOR - The present invention relates to a pharmaceutical combination composition comprising at least one renin-angiotensin-aldosterone system inhibitor in a subtherapeutic daily dose and at least one HMG-CoA reductase inhibitor in a subtherapeutic daily dose for use in maintaining or improving the functional and morphological properties of the arterial wall in a subject having at least one cardiovascular disorder or having at least one risk factor for cardiovascular disorder. | 2014-10-30 |
20140323537 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF - Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described. | 2014-10-30 |
20140323538 | ANTICANCER P21-ACTIVATED KINASE INHIBITORS - Compounds according to formula I: | 2014-10-30 |
20140323539 | Emulsifiable Concentrate Comprising Pesticide, Dimethyl Sulfoxide, Benzyl Alcohol, Alkyl Lactate and Diester - Subject matter of the present invention is an emulsifiable concentrate comprising a water-insoluble pesticide, dimethyl sulfoxide, benzyl alcohol, alkyl lactate and a diester of the formula (I) | 2014-10-30 |
20140323540 | USE OF A DITHIINO-TETRACARBOXAMIDE FOR THE PROTECTION OF HARVESTED PRODUCTS AGAINST PHYTOPATHOGENIC FUNGI - The present invention relates to methods for the protection of harvested fruits, cutflowers or vegetables against decay caused by certain storage diseases or disorders expressed in storage conditions, which fruits, cutflowers or vegetables have been treated pre-harvest with dithiino-tetracarboximides for formula (I). In particular the invention relates to the application of dithiino-tetracarboximides of formula (I) before harvest to protect harvested fruit, cutflowers or vegetables against phytopathogenic fungi. | 2014-10-30 |
20140323541 | Methods And Compositions For Prevention Or Treatment Of RSV Infection Using Modified Duplex RNA Molecules - Methods and compositions are provided for the prevention or treatment of RSV infection in a human. The methods include administering one or more doses of a composition comprising an siRNA. The dose can be formulated for topical or parenteral administration. Topical administration includes administration as a nasal spray, or by inhalation of respirable particles or droplets. The siRNA preferably comprises a sense strand and antisense strand with modified nucleotides. | 2014-10-30 |
20140323542 | TARGETING DOMAIN AND RELATED SIGNAL ACTIVATED MOLECULAR DELIVERY - Provided herein are signal activatable molecular constructs for enzyme-assisted delivery of molecules and related components, such as a sensor domain, compositions, methods and systems. | 2014-10-30 |
20140323543 | Treatment of Prostate Cancer with eIF4E Antisense Compounds - The present invention provides methods of sensitizing cancer cells to docetaxel and inhibiting the growth of various tumors by employing a modified eIF-4E antisense oligonucleotide and docetaxel in combination. | 2014-10-30 |
20140323544 | EXON SKIPPING COMPOSITIONS FOR TREATING MUSCULAR DYSTROPHY - Antisense molecules capable of binding to a selected target site in the human dystrophin gene to induce exon 44 skipping are described. | 2014-10-30 |
20140323545 | NITRATED SPHINGOSINE 1-PHOSPHATE 3 RECEPTOR AS A PREDICTOR OF ACUTE LUNG INJURY-ASSOCIATED MORTALITY - The disclosure relates to a method of determining risk of mortality from Acute Lung Injury (ALI), sepsis, or a combination thereof in a patient, as well as a method of diagnosing ALI in a patient with sepsis based on the presence of tyrosine-nitrated sphingosine 1-phosphate 3 receptor (S1P3R) protein. The disclosure additionally relates to a method of treating an Acute Lung Injury (ALI) patient with sepsis based on the presence of tyrosine-nitrated S1P3R protein. | 2014-10-30 |
20140323546 | PME-1 AS A BIOMARKER TO PREDICT AND DIAGNOSE AN INCREASED RISK OF ENDOMETRIAL CANCER AND GENE SILENCING OF PME-1 TO INHIBIT EPITHELIAL TO MESENCHYMAL TRANSITION - Disclosed are methods of attenuating activity of the PME-1 gene. siRNAs or shRNAs are used to target against PME-1, thereby reducing the PME-1 mRNA. It is disclosed that the siRNAs or shRNAs targeted against PME-1 attenuate the epithelial to mesenchymal transition, thereby inhibit endometrial cancer development. A kit containing siRNA or shRNA reagents for attenuating the PME-1 gene expression is also disclosed. | 2014-10-30 |
20140323547 | FAT1 GENE IN CANCER AND INFLAMMATION - The present invention demonstrates for the first time that FAT1 plays an important role in modulating PDCD4 expression, which in turn regulates AP-1 dependent transcription, controls processes crucial for migration and invasion in cancer cells, controls induction of a pro-inflammatory micro environment in cancer cells. The study illustrates a link between inflammation and cancer in cells or in a subject. This work highlights the importance of FAT1 in the induction of the cellular pathways of migration and invasion, proteolysis of the ECM and the expression of pro-inflammatory molecules leading to a favorable micro environment for tumor and cancer progression. The present invention also provides the use of FAT1 in regulating neoplastic phenotypes and genotypes including invasiveness and inflammatory micro environment of the cancer cells by acting as a novel apical regulator of a signaling pathway by affecting the AP1 transcriptional activity, affecting the property of both cell migration and invasion and at the same time affecting the expression of inflammatory modulators. The present invention also identifies a novel regulatory pathway for inflammatory mediators and inflammatory cellular responses via PDCD4 and AP1. The invention describes a pathway for the upregulation of inflammatory processes as such, and hence a means of regulating inflammatory pathologies in general. | 2014-10-30 |
20140323548 | NOVEL AMINO ALCOHOL CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY - The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that is more efficacious than traditional cationic lipids. The present invention employs amino alcohols to enhance the efficiency of in vivo delivery of siRNA. | 2014-10-30 |
20140323549 | METHODS AND COMPOSITIONS FOR TREATING DISEASES, DISORDERS OR INJURY OF THE NERVOUS SYSTEM - Disclosed herein are compositions and methods of use thereof for treating diseases, disorders and injuries of the nervous system, comprising a combination of a RTP801 or RTP801L inhibitor, and a Casp2 inhibitor. | 2014-10-30 |
20140323550 | INTESTINAL FIBROSIS TREATMENT AGENT - The present invention relates to a carrier for delivering a substance to extracellular matrix-producing cells in the intestine, the carrier containing a retinoid as a targeting agent, and an agent for treating fibrosis of the intestine utilizing the carrier. | 2014-10-30 |
20140323551 | TARGETING MICRORNAS MIR-409-5P, MIR-379 AND MIR-154* TO TREAT PROSTATE CANCER BONE METASTASIS AND DRUG RESISTANT LUNG CANCER - The present invention describes methods of treating cancer, cancer metastasis, and drug resistant cancers using miRNA inhibitors; for example, inhibitors of miR-409-5p. Also described are methods of using the miRNA as biomarkers; for example, to predict responsiveness to a cancer drug, to detect a disease state of cancer. | 2014-10-30 |
20140323552 | NON-IONIC, LOW OSMOLAR CONTRAST AGENTS FOR DELIVERY OF ANTISENSE OLIGONUCLEOTIDES AND TREATMENT OF DISEASE - Disclosed are compositions comprising an antisense oligonucleotide and a non-ionic, low-osmolar contrast agent. Also disclosed are methods of delivering an antisense oligonucleotide to a target sire comprising incorporating the antisense oligonucleotide into a composition comprising a non-ionic, low-osmolar contrast agent. Also disclosed are methods of treating a neurodegenerative disease comprising administering one or more of the compositions disclosed herein. | 2014-10-30 |
20140323553 | Methods and Compositions Related to MiR-21 & MiR-29a, Exosome Inhibition, and Cancer Metastasis - The present invention provides materials and methods related to the discovery that tumor secreted miR-21 and miR-29a can function by binding as ligands to receptors of the Tolllike receptor family, murine TLR7 and human TLR8, in immune cells, triggering a TLR-mediated prometastatic inflammatory response, which leads to tumor growth and metastasis. Thus, by acting as paracrine agonists of TLRs, secreted miRNAs are key regulators of the tumor microenvironment. This mechanism of action of miRNAs is important in the tumor-immune system communication, in tumor growth and spread, and in cancer treatment. | 2014-10-30 |
20140323554 | NUCLEOTIDE AND OLIGONUCLEOTIDE PRODRUGS - The present invention discloses compounds of formula (I): | 2014-10-30 |
20140323555 | tRNA DERIVED SMALL RNAs (tsRNAs) INVOLVED IN CELL VIABILITY - The present invention features compositions and methods relating to tRNA-derived small RNAs (tsRNAs). Provided herein are oligonucleotide compositions that are complementary to tsRNAs, in particular leuCAGtsRNA, and methods of using the oligonucleotides for the regulation of respective tsRNA. Further provided are methods of inducing apoptosis through the inhibition of leuCAGtsRNA. | 2014-10-30 |
20140323556 | SCALABLE MANUFACTURING PROCESS TO PRODUCE RECOMBINANT LENTIVIRAL VECTORS IN SERUM-FREE SUSPENSION CELL CULTURE SYSTEM - Methods for preparing highly purified rLV vector formulations at the scale needed to meet anticipated demand for human gene therapy are provided. | 2014-10-30 |
20140323557 | COMPOUNDS FOR THE MODULATION OF BETA-CATENIN EXPRESSION AND USES THEREOF - The invention relates to oligomer compounds (oligomers), which target beta-catenin mRNA in a cell, leading to reduced expression of beta-catenin. Reduction of beta-catenin expression is beneficial for a range of medical disorders, such as hyperproliferative disorders, such as cancers. The invention provides therapeutic compositions comprising oligomers and methods for modulating the expression of beta-catenin using said oligomers, including methods of treatment for hyperproliferative disorders including cancers such as multiple myeloma. | 2014-10-30 |
20140323558 | THERAPEUTIC AGENTS - The invention provides well-defined compounds that are either EP | 2014-10-30 |
20140323559 | LONG-ACTING INJECTABLE MOXIDECTIN FORMULATIONS AND NOVEL MOXIDECTIN CRYSTAL FORMS - This invention provides for novel antiparasitic and pesticidal forms of moxidectin, including a long-acting polymeric implant. The resulting compounds may be used in veterinary compositions which are used in treating, controlling and preventing of endo- and ectoparasite infections in animals. | 2014-10-30 |
20140323560 | CHROMAN-DERIVED ANTI-ANDROGENS FOR TREATMENT OF ANDROGEN MEDIATED DISORDERS - Methods for the prevention and/or alleviation of androgen-mediated disorders treatable by administering a chroman-derived anti-androgen compound are provided by the present invention. The invention further provides pharmaceutical and nutraceutical compositions containing chroman-derived anti-androgen compounds useful in the prevention and/or alleviation of androgen-mediated disorders, particularly prostate cancer. | 2014-10-30 |
20140323561 | Control and repellency of biting flies, house flies, ticks, ants, fleas, biting midges, cockroaches, spiders and stink bugs - Control and repellency of biting flies, house flies, ticks, ants, fleas, biting midges, cockroaches, spiders and stink bugs is obtained by contact of the insects with at least one of the compounds of the structure (I). | 2014-10-30 |
20140323562 | THIOSULFINATE ANTIOXIDANTS AND METHODS OF USE THEREOF - The present application provides compound of Formula X | 2014-10-30 |
20140323563 | USE OF STRIGOLACTONES AND STRIGOLACTONE ANALOGS FOR TREATING PROLIFERATIVE CONDITIONS - Compound of formula X wherein P | 2014-10-30 |
20140323564 | COMPOSITION CONTAINING ISOSORBIDE MONOESTER AND ISOSORBIDE DIESTER - What are described are compositions comprising | 2014-10-30 |
20140323565 | Oligomer-Calcimimetic Conjugates and Related Compunds - The invention relates to (among other things) oligomer-calcimimetic conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered compounds. | 2014-10-30 |
20140323566 | SELF-MAGNETIC METAL-SALEN COMPLEX COMPOUND - A new self-magnetic metal-salen complex compound and its derivatives are provided. The present invention is a metal-salen complex compound including any one of the following compounds. | 2014-10-30 |
20140323567 | CONTROLLED RELEASE PHARMACEUTICAL FORMULATIONS - Disclosed herein are drug release polymer compounds and compositions comprising prostacyclin compounds of Formula (I), and methods of preparing the same. A preferred polymer has a repeating unit of the following structure: | 2014-10-30 |
20140323568 | OLIGO-BENZAMIDE COMPOUNDS AND THEIR USE IN TREATING CANCERS - The present invention includes bis- and tris-benzamide compounds that block AR signaling and have activity against prostate cancer. Uses for these compounds, and pharmaceutical compositions containing the same, also are provided. | 2014-10-30 |
20140323569 | MICROBIAL OILS ENRICHED IN POLYUNSATURATED FATTY ACIDS - The present invention is directed to microbial oils that are enriched in their content of polyunsaturated fatty acids, their esters, their acid salts, alcohols formed therefrom, and/or aldehydes formed therefrom. The present invention is further directed to compositions containing the enriched microbial oils and methods of making and using the enriched microbial oils. The present invention is also directed to isolated microorganisms as well as strains and mutants thereof, biomasses, microbial oils, compositions, and cultures; methods of producing the microbial oils, biomasses, and mutants; and methods of using the isolated microorganisms, biomasses, and microbial oils. | 2014-10-30 |
20140323570 | Neuroprotection in Demyelinating Diseases - Methods of treating neurological disorders characterized by extensive demyelination and/or axonal loss are provided. Examples of such disorders include secondary progressive multiple sclerosis and Devic's disease. The disclosed methods include administering to a subject having such a disorder a therapeutically effective amount of, for example, dimethyl fumarate or monomethyl fumarate. | 2014-10-30 |
20140323571 | PREVENTION OF PSYCHOTIC DISORDERS AND/OR TREATMENT OF PSYCHOTIC SYMPTOMS - The present invention relates to methods of preventing a psychotic disorder in a subject in need of intervention including administering to the subject a composition including EPA (eicosapentanoic acid) and DHA (docosahexaenoic acid). Methods of treating pre-psychotic symptoms in a subject, including administering to the subject a composition including EPA and DHA are also included. | 2014-10-30 |
20140323572 | Antimicrobial Mixture of Aldehydes, Organic Acids and Fatty Acid Esters - An antimicrobial composition and method for extending the shelf-life of water, food/feed or food/feed ingredients, comprising: 5-25 wt. % nonanoic acid, 1-25 wt. % organic acid ester, 1-50 wt. % of a single or mixture of C | 2014-10-30 |
20140323573 | METABOLIZABLE SALTS AND USE THEREOF IN DIAGNOSTICS AND THERAPY - The present invention proposes novel salt compounds for use in the diagnosis or therapy of a patient as well as drugs, medical products, diagnostic compositions or blood products containing a salt compound according to the invention. The salt compounds according to the invention comprise the cation of a metabolisable basic amino acid and the anion of a metabolisable carboxylic acid or an anion of carbonic acid. Those salt compounds therefore have the advantage that they are fully metabolisable and thus do not adversely affect the electrolyte balance or the acid-base balance of the patient. The proposed salt compounds are particularly suitable for the therapy of the liquid and electrolyte balance of a patient but also for adjusting the pH-value in a biological or medical sample, for adjusting the osmolality in infusion solutions, as buffer substances, for feeding biocarbonate to a patient and for inhibiting blood coagulation for example in a patient, in extracorporeal blood treatment in the diagnostic determination of blood coagulation or in the production, storage and preparation of blood products. | 2014-10-30 |
20140323574 | INFANT FORMULA WITH HIGH SN-2 PALMITATE AND OLIGOFRUCTOSE - An infant formula having a relatively high content of triglycerides having palmitic acid in the sn-2 position. The formula may include oligofructose. The formula may also include at least one omega 6 fatty acid and at least one omega 3 fatty acid. The formula may also have a relatively low protein content and an alpha-lactalbumin content similar to human milk The invention also includes a method for improving the stool consistency, increasing bifidobacteria in the colon, reducing potentially pathogenic bacteria in the colon and reducing calcium soaps in the stool of a formula-fed infant. | 2014-10-30 |
20140323575 | TYROSINE ISOMERS AS THERAPEUTIC AGENTS - The present invention relates to prevention or treatment of diseases related to abnormal cell proliferation, such as cancer, by administering meta- or ortho-tyrosine to a subject in need thereof, for instance a human subject. More specifically, the present invention provides isomers of tyrosine for its use in the prevention or treatment of a disease and in the preparation of pharmaceutical compositions, methods of treating or preventing diseases, such as cancer and cancer metastases, and pharmaceutical compositions containing meta- and/or ortho-tyrosine. | 2014-10-30 |
20140323576 | METHOD FOR TREATING GLIOBLASTOMAS AND OTHER TUMORS - Methods of treating an astrocytoma with agents effective to inhibit microglia function are provided, as well as methods of enhancing the efficacy of brain tumor radiation therapy on an astrocytoma in a subject. Also provided are methods of treating other solid tumor types, and tumor cell invasion, with guanylhydrazone compounds. | 2014-10-30 |
20140323577 | METHODS FOR REDUCING THE RISK OF CONVERSION TO CLINICALLY DEFINITE MULTIPLE SCLEROSIS - This invention relates to a method for reducing the risk of conversion to clinically definite multiple sclerosis (CDMS) in patients who have experienced their first neurological symptoms consistent with clinically isolated syndrome (CIS). | 2014-10-30 |
20140323578 | POLYMERIC COLORANT COMPOSITIONS AND METHODS OF USE - A composition is disclosed. The composition comprises at least one polymeric colorant having a polymer component with a colorant component covalently bound thereto, a medicament, and a liquid vehicle. The at least one colorant component does not react directly or indirectly with the medicament. Methods of using the polymeric colorants, including a method for the preparation of skin as a site for a surgical procedure and a method of treating a medical condition, are also provided. | 2014-10-30 |
20140323579 | 2,2-DIFLUOROPROPIONAMIDE DERIVATIVES OF BARDOXOLONE METHYL, POLYMORPHIC FORMS AND METHODS OF USE THEREOF - The present invention relates generally to the compound:
| 2014-10-30 |
20140323580 | PHENTERMINE LIQUID DOSAGE FORM - A pharmaceutical composition liquid dosage form of phentermine is provided, the dosage form including a liquid carrier and suspended or dissolved therein one or more pharmaceutically active ingredient selected from phentermine, salts and bases thereof. Also provided is a method of administering phentermine to an obese patient in need thereof and for appetite suppression or related conditions. | 2014-10-30 |
20140323581 | TRANSCRIPTOME WIRING ANALYSIS IN PARKINSON'S DISEASE AND USES THEREOF - The invention is directed to methods to identify predisposition or risk to develop Parkinson's disease, methods to identify agents which have therapeutic effect on Parkinson's disease, and methods to determine the therapeutic effect of an agent in a subject suffering from Parkinson's disease, and to kits and reagents for carrying out the methods of the invention. | 2014-10-30 |
20140323582 | COMPOSITION AND METHOD FOR TREATING NEUROLOGICAL DISEASE - A method of administering amantadine is provided. The method comprises orally administering to a subject a pharmaceutical composition comprising amantadine, or a pharmaceutically acceptable salt thereof, and one or more excipients, wherein at least one of the excipients modifies release of the amantadine. A dose of the composition provides a mean change in amantadine plasma concentration as a function of time (dC/dT) that is less than 40% of the change in amantadine plasma concentration provided by a dose of the same quantity of an immediate release form of amantadine. The change in plasma concentration over time (dC/dT) is measured in a single dose human pharmacokinetic study in a defined time period of 0 to 4 hours after administration. The amantadine, or pharmaceutically acceptable salt thereof, is administered once daily at a dose of 300 to 500 mg per day. | 2014-10-30 |
20140323583 | CINNAMALDEHYDE AND DIALLYL DISULFIDE FORMULATIONS AND METHODS OF USE - The present invention relates to agricultural emulsion concentrates which form stable oil-in-water emulsions when diluted with water. More specifically, the invention relates to stable oil-in-water emulsions which include cinnamaldehyde and diallyl disulfide with a Calsogen® EH and Surfonic® CO 36 emulsion system. The increased stability of the emulsion allows for efficient mixing of the emulsion ingredients and effective storage and application of the cinnamaldehyde and diallyl disulfide to areas in need of nematode protection or treatment. | 2014-10-30 |
20140323584 | MICROBIAL COMPOSITION - A synergistic microbicidal composition comprising: (a) at least one microbicide selected from the group consisting of a monosubstituted phenol and an isopropyl methyl phenol; and (b) at least one microbicide selected from the group consisting of substituted cyclohexyl propyl-1,3-diols, propen-2yl-methyl cyclohexanols and menthadiene alcohols. | 2014-10-30 |
20140323585 | MICROBIAL COMPOSITION - A synergistic microbicidal composition containing synergistic combinations of a phenolic compound selected the class consisting of chlorinated phenols, monosubstituted phenols, fused bicyclic phenols, isopropyl methyl catechols and monosubstituted catechols and an antimicrobial alcohol selected from the class consisting of propen- | 2014-10-30 |
20140323586 | Agent for Reduction of Sensory Irritation - Provision of a TRPA1 activity inhibitor capable of reducing sensory irritation to skin or mucous membrane and an agent for reduction of sensory irritation for skin or mucous membrane. A TRPA1 inhibitor and an agent for reduction of sensory irritation for skin or mucous membrane comprising as an active ingredient a compound represented by the following formula (1) wherein R | 2014-10-30 |
20140323587 | SOLID FORMULATIONS OF LIQUID BIOLOGICALLY ACTIVE AGENTS - The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent; particularly a solid product that can be reconstituted to a clear, stable, stabilized nanodispersion or loaded micelles comprising a polymer as a stabilizing agent and a liquid, preferably water immiscible, biologically active agent. The instant invention is further directed toward a process for the production of the above solid product; particularly to micelles or nanodispersions produced by hydration of a cake or powder of the solid product, produced via an effective treatment of a stabilized solution comprising for example a polymer as a stabilizing agent, such as an amphiphilic block copolymer or a small molecular weight surfactant, loaded with a liquid biologically active agent, such as propofol, an optional additive, and a suitable solvent. | 2014-10-30 |
20140323588 | Topical Formulation for Pain Relief - Described herein are topical pain compositions comprising between 15 and 90% mannitol, for use in the treatment of pain, itch and other cutaneous nerve conditions. The resulting compositions may be in the form of creams, gels, lotions, ointments, foams, suppositories, and sprays. | 2014-10-30 |
20140323589 | Method for the preparation of composite silica alcogels, aerogels and xerogels, apparatus for carrying out the method continuously, and novel composite silica alcogels, aerogels and xerogels - The invention relates to a method for the preparation of composite silica alcogels, aerogels and xerogels, comprising
| 2014-10-30 |
20140323590 | POWDER TREATMENT AGENT COMPRISING SUGAR ALCOHOL-MODIFIED ORGANOPOLYSILOXANE - The present invention has an objective to provide a surface treatment agent which is safe with no generation of hydrogen, can be suitably used in a surface treatment of powder(s), exhibits good compatibility with other raw materials of cosmetics, and therefore, can improve a dispersing property and stability of powder(s) contained in a cosmetic, as well as provide a powder which has been subjected to a surface treatment with the aforementioned powder treatment agent, and a cosmetic raw material and a cosmetic which are produced by blending them, exhibit superior storage stability, have a superior outer appearance, and exhibit a superior sensation during use. A sugar alcohol-modified organopolysiloxane having a specified structure is used in the powder treatment. | 2014-10-30 |
20140323591 | Water-Based Skin Cosmetic - The present invention provides a water-based skin cosmetic comprising the following ingredients (A) and (B)
| 2014-10-30 |
20140323592 | USE OF ISOSORBIDE DIESTERS AS THICKENERS - The use of one or more compounds of the formula (I) | 2014-10-30 |
20140323593 | METHODS AND APPARATUS FOR THE CONTROL OF ADENOSINE TRIPHOSPHATE SYNTHASE ACTIVITY WITHIN LIVING ORGANISMS, AND CONDITIONING OF WATER-BASED FLUIDS AND SUBSTANCES USING MAGNETIC FIELD EXPOSURES OR THEIR WITHDRAWAL - The present invention relates to the control by magnetic fields (MF) of the activity of the mitochondrial enzyme adenosine triphosphate synthase (ATPS). Elimination of alternating and static MFs allows ATPS activity amplification (ATPSA), while a variety of MF frequency-intensity combinations interfere to various degrees with ATPS function (ATPSI). Control of ATPS, which is the endpoint of the mitochondrial oxidative phosphorylation system, allows alteration of intracellular adenosine triphosphate (ATP) levels, a molecule critical to the function of living organisms. Changes in ATP levels may trigger various events in cells, and prolonged ATPSI can lead to cell death. Specific combinations of MF frequencies and intensities maximize ATPSI for cancer cell killing and other health related applications. | 2014-10-30 |
20140323594 | METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE - The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of Cytoplasmic aspartate aminotransferase, soluble Tumor necrosis factor receptor superfamily member 5, soluble CD40 Ligand, soluble C-X-C Motif chemokine 16, S100-A12, Eotaxin, soluble E-selectin, Fibronectin, Granulocyte colony-stimulating factor, Granulocyte-macrophage colony-stimulating factor, Heparin-binding growth factor 2, soluble Hepatocyte growth factor receptor, Interleukin-1 receptor antagonist, Interleukin-1 beta, Interleukin-10, Interleukin-15, Interleukin-3, Myeloperoxidase, Nidogen-1, soluble Oxidized low-density lipoprotein receptor 1, Pappalysin-1, soluble P-selectin glycoprotein ligand 1, Antileukoproteinase, soluble Kit ligand, Tissue inhibitor of metalloproteinase 1, Tissue inhibitor of metalloproteinase 2, soluble Tumor necrosis factor, soluble Vascular cell adhesion molecule 1, and Vascular endothelial growth factor A as diagnostic and prognostic biomarkers in renal injuries. | 2014-10-30 |
20140323595 | GM1 GANGLIOSIDE TO ANNEXIN V MICROPARTICLE POLYPEPTIDE RATIO FOR BIOLOGICAL MONITORING - We describe a method of monitoring the state of a cell, tissue, organ or organism. The method comprises establishing, for a sample of microparticles from the cell, tissue, organ or organism, a ratio. The ratio is of a selected polypeptide in microparticles which comprise GM1 gangliosides, preferably which bind to Cholera Toxin B (CTB) (“GM1 ganglioside microparticle polypeptide”) to the selected polypeptide in microparticles which comprise exposed phosphotidylserine, preferably which bind to Annexin V (“Annexin V microparticle polypeptide”). The GM1 ganglioside microparticle polypeptide to Annexin V microparticle polypeptide ratio so established may be indicative of the state of the cell, tissue, organ or organism. | 2014-10-30 |
20140323596 | GRAPHENE OXIDE REDUCED MATERIAL DISPERSED AT HIGH CONCENTRATION BY CATION-II INTERACTION AND METHOD FOR MANUFACTURING SAME - The present invention relates to a graphene oxide reduced material dispersed at a high concentration by a cation-π interaction and to a method for manufacturing same, and more particularly to a method for manufacturing a graphene oxide reduced material dispersed in a high concentration by a cation-π interaction comprising: a first step of synthesizing graphite oxide flakes in a powder state from graphite flakes in a powder state; a second step of forming a graphene oxide dispersion solution by dispersing the graphite oxide flakes of the first step into a solvent; a third step of preparing a cation reaction graphene oxide dispersion solution through the interaction of a cation and a π-structure in an sp | 2014-10-30 |
20140323597 | METHOD AND SYSTEM FOR PRODUCING METHANOL USING AN INTEGRATED OXYGEN TRANSPORT MEMBRANE BASED REFORMING SYSTEM - A method and system for producing methanol that employs an integrated oxygen transport membrane based reforming system is disclosed. The integrated oxygen transport membrane based reforming system carries out a primary reforming process, a secondary reforming process, and synthesis gas conditioning to produce synthesis gas having a desired module of between about 2.0 and 2.2 for a methanol production process thereby optimizing the efficiency and productivity of the methanol plant. | 2014-10-30 |
20140323598 | METHOD AND SYSTEM FOR PRODUCING A SYNTHESIS GAS USING AN OXYGEN TRANSPORT MEMBRANE BASED REFORMING SYSTEM WITH SECONDARY REFORMING AND AUXILIARY HEAT SOURCE - A method and system for producing a synthesis gas in an oxygen transport membrane based reforming system is disclosed that carries out a primary reforming process within a reforming reactor, and a secondary reforming process within an oxygen transport membrane reactor and in the presence of heat generated from a oxygen transport membrane reactor and an auxiliary source of heat. The auxiliary source of heat is disposed within the reactor housing proximate the reforming reactors and may include an auxiliary reactively driven oxygen transport membrane reactor or a ceramic burner. | 2014-10-30 |
20140323599 | METHOD AND SYSTEM FOR PRODUCING METHANOL USING AN OXYGEN TRANSPORT MEMBRANE BASED REFORMING SYSTEM - A method and system for producing methanol that employs both an oxygen transport membrane (OTM) based reforming system together with a more traditional steam methane reforming (SMR) and/or autothermal (ATR) synthesis gas production system is disclosed. The dual mode system and method for producing the synthesis gas in a methanol production process optimizes the efficiency and productivity of the methanol plant by using the OTM based reforming system as an independent source of synthesis gas. The disclosed methods and systems are configurable either as a retrofit to existing methanol production facilities or as an integrated package into newly constructed methanol production facilities. | 2014-10-30 |
20140323600 | Process for the Conversion of Carbon Dioxide to Methanol - Carbon monoxide conversion processes are described for the conversion of carbon monoxide via hydrogenation to methanol. The process utilizes initial carbon monoxide priming before introduction of 3:1 hydrogen/carbon dioxide mixture to the reactor. After the optimum reaction conditions are established the feed of carbon monoxide may be withdrawn and any required carbon monoxide provided via reactor effluent recycle. The process provides for enhanced catalyst performance and life. | 2014-10-30 |
20140323601 | Fischer-Tropsch Catalyst - The present invention is directed to a catalyst suitable for catalyzing a Fischer-Tropsch reaction, said catalyst comprising cobalt metal supported on zinc-oxide and having the following particle size distribution by volume: <10% having a particle size below 1 micron, 70-99% having a particle size between 1 and 5 micron, and <20% having a particle size above 5 micron. | 2014-10-30 |
20140323602 | DIRECT PRINTING METHOD WITH A BASE LAYER - A method and a device for direct printing onto plastic containers, where an intermediate layer is in a first step using a first device applied onto the container to be printed and the container is in a second step using a second device printed in certain areas, and the intermediate layer enters into a bond with the container and the print layer that is insoluble in aqueous solutions having a pH value between 3 and 10, and is very soluble in aqueous solutions having a pH value in a range less than 3 and/or greater than 10; and a recycling method for a plastic container having an intermediate layer applied. | 2014-10-30 |
20140323603 | PROCESS AND APPARATUS FOR A NANOVOIDED ARTICLES - A process and apparatus for producing a nanovoided article, a nanovoided coating, and a low refractive index coating is described. The process includes providing a first solution of a polymerizable material in a solvent; at least partially polymerizing the polymerizable material to form a composition that includes an insoluble polymer matrix and a second solution, wherein the insoluble polymer matrix includes a plurality of nanovoids that are filled with the second solution; and removing a major portion of the solvent from the second solution. An apparatus for the process is also described, and includes a webline, a coating section, a partial polymerization section, and a solvent removal section. | 2014-10-30 |
20140323604 | DUAL-FOAMED POLYMER COMPOSITION - A polymer foam having high bonding strength and improved compressive hardness characteristics is accomplished by the polymer foam comprising cavities formed by microballoons, and also 2 to 20 vol. %, based on the total volume of the polymer foam, of cavities surrounded by the polymer foam matrix. | 2014-10-30 |
20140323605 | STABLE EMULSIONS AND THEIR USE IN THE PRODUCTION OF FOAMS BASED ON ISOCYANATE - The invention relates to stable emulsions for the production of foams based on isocyanate, at least comprising three polyols A1a, A1b and A1c as well as at least one physical blowing agent T, wherein A1a is a polyether polyol obtained by addition of epoxides to starter compounds selected from carbohydrates and di- or higher-functional alcohols, A1b is a polyether polyol started on an aromatic amine, and A1c is a polyester polyol obtained by esterification of a polycarboxylic acid component and a polyalcohol component, wherein the total amount of aromatic dicarboxylic acid derivatives used in the esterification, calculated on the basis of the free aromatic dicarboxylic acids and based on the total mass of polyalcohol component and polycarboxylic acid component, is less than or equal to 48.5% by mass. | 2014-10-30 |
20140323606 | RUBBER-MODIFIED FLAME-RETARDANT MOULDING COMPOSITIONS AND PRODUCTION THEREOF - The invention relates to thermoplastic moulding compositions comprising A) between 55 to 98% in weight of at least one vinyl aromatic copolymer modified with a particulate graft rubber, B) between 1 to 44% in weight of a flame retardant comprising B1) an expandable graphite, B2) a flame-retardant compound comprising phosphorus, and B3) a fluorine-containing polymer, C) between 1 to 20% in weight of a non-particulate-forming rubber comprising polar groups, and D) between 0 to 40% in weight of additional additives, where the weight percentages are respectively based on the total weight of components A) to D), and said percentages add up to a total of 100% in weight, and the polybutadiene content is between 0 to 11I % in weight. | 2014-10-30 |
20140323607 | COMPOSITION OF NANOCOMPOSITE CONTAINING GRAPHENE SHEETS - A novel nanocomposite having graphene sheets is described. The nanocomposite may be used for medical devices such as bone cement, dentures, paper, paint and automotive industries. A novel Microwave irradiation (MWI) was used to obtain R-(GO-(STY-co-MMA)). The results indicate that the nanocomposite obtained using the MWI had a better morphology and dispersion with enhanced thermal stability compared with the nanocomposite prepared without MWI. An average increase of 136% in hardness and 76% in elastic modulus were achieved through the addition of only 2.0 wt % of RGO nanocomposite obtained via the MWI method. | 2014-10-30 |
20140323608 | POLYMER DISPERSIONS - A polymer dispersion comprises particles of a polymer composition formed at least partially by emulsion polymerization of first and second, simultaneously added, substantially styrene-free monomer feeds in the presence of an initiator in a reaction zone. The first monomer feed comprises monomers selected to produce a copolymer having a glass transition temperature less than or equal to about −10° C., while the second monomer feed comprises monomers selected to produce a copolymer having a glass transition temperature greater than or equal to about 50° C. The relative rate of addition of the first and second monomer feeds into the reaction zone is continuously changed during at least part of the emulsion polymerization and the rate of addition of the initiator is changed step-wise at least once during the addition of the first and second monomer feeds. | 2014-10-30 |
20140323609 | POLYACRYLAMIDE BASED AGRICULTURAL COMPOSITIONS - A polyacrylamide based agricultural composition as a microemulsion is provided in form of a water-in-oil microemulsion with polyacrylamide dissolved in the water phase where the polyacrylamide solids content is from about two up to about 15 percent by weight, which is then further diluted in water at the time of use to impart the desired characteristics of the polymer to the water phase or to the material to which the water phase is applied. | 2014-10-30 |
20140323610 | METHOD FOR PREPARING GRAPHENE OXIDE/WHITE CARBON BLACK/RUBBER NANOCOMPOSITE MATERIAL - A method for preparing a graphene oxide/white carbon black/rubber nanocomposite material is described. The prepared graphene oxide/white carbon black/rubber nanocomposite material contains nanoscale graphene oxide and white carbon black that are highly dispersed. The nanocomposite material has a relatively high modulus, excellent wear resistance and tear resistance, a relatively low rolling resistance, and at the same time has a low air-permeability and excellent self-healing capability. | 2014-10-30 |
20140323611 | STRUCTURAL ADHESIVE SHEET SPECIFICALLY FOR USE IN A MIRROR BASE OF AN AUTOMOBILE INTERIOR REAR-VIEW MIRROR AND A METHOD FOR PRODUCING THE SAME - The present invention provides a structural adhesive sheet specifically for use in a mirror base of an automobile interior rear-view mirror and a method for producing the same, said structural adhesive sheet comprises in parts by weight of 20-100 parts of a nitrile-butadiene rubber, 10-70 parts of a partially cured polysulfide adhesive, 5-40 parts of a bisphenol A type epoxy resin, 0.1-2.5 parts of a crosslinking agent, 0.2-2.5 parts of a softening agent, 3-20 parts of a curing agent, 1-10 parts of an accelerator, 20-100 parts of an inorganic filler, and 0.1-3.0 parts of a silane coupling agent. The structural adhesive sheet of the present invention is obtained by subjecting the above-mentioned components to a compounding process and an extrusion film forming process. The advantages of said structural adhesive sheet include good film-forming property, and simple curing process, while having high structural strength, good toughness, and excellent heat-resistance and cold-resistance after cured. | 2014-10-30 |
20140323612 | ANTIREFLECTION COATING FILM AND ANTIREFLECTION COATING MATERIAL FOR OPTICAL ELEMENT AND OPTICAL ELEMENT - An antireflection coating film for an optical element is provided on a surface of a substrate of an optical material and includes first particles having a refractive index (nd) of at least 2.2 or more for the d-line and an average particle size of 10 to 70 nm, second particles of at least one of silica and sericite and having an average particle size of 1 to 11 μm, a colorant of an organic substance and soluble in an organic solvent, and a resin, in which the first particle content is in the range of 10% to 35% by weight, and second particle content is in the range of 1% to 11% by weight. The antireflection coating film has a high effect of preventing surface reflection, a high effect of preventing inner-surface reflection, satisfactory absorption of visible light, and low levels of reflection and scattering in the film. | 2014-10-30 |
20140323613 | Dual Cure System - Multi-pack curable composition comprising: a first pack comprising a blend of (i) an epoxy resin, (ii) an unsaturated polyester or vinyl ester resin, and optionally (iii) a peroxyester, a second pack comprising an amine curing agent for the epoxy resin and at least one transition metal compound selected from iron, copper, and manganese compounds, and at least when the first pack does not contain a peroxyester, a third pack comprising a peroxide. | 2014-10-30 |
20140323614 | PLASTICIZING MIXTURE FOR A HYDRAULIC COMPOSITION - A mixture for a hydraulic composition, including an inerting agent for at least partially neutralizing the harmful effects of impurities in a hydraulic composition on the workability of the hydraulic composition; a first superplasticizer different from the inerting agent; and a second superplasticizer different from the first superplasticizer and the inerting agent and having a maximum plasticizing action at 20° C. developing after the peak of the plasticizing action at 20° C. of the first superplasticizer. | 2014-10-30 |
20140323615 | WOOD FILLER WITH HOT MELT ADHESIVE - A wood-filling composition that includes at least one hot melt adhesive, wherein the at least one hot melt adhesive further includes ethylene-vinyl acetate, polyethylene, polypropylene, or combinations thereof; and at least one filler, wherein the at least one filler further includes ceramic microspheres, calcium carbonate, wood flour, or combinations thereof. | 2014-10-30 |
20140323616 | EGGSHELL POWDER COMPOSITIONS AND METHODS OF PRODUCING EGGSHELL POWDER COMPOSITIONS - A process for manufacturing eggshell powder for use in the production of bio-based products is provided. The process involves exposing a quantity of eggshell to high air speed at room temperatures to pulverize the eggshell and separate the eggshell component from the inner membrane component. Thus, the process avoids the use of high temperatures and other harsh chemical treatments to remove the inner membrane from the eggshell thereby resulting in an eggshell material that retains the original lipid-protein structure of the native eggshell from which the powder derives. Accordingly, an eggshell powder composition is provided that is substantially free of inner membrane material and possesses a lipid-protein structure substantially similar to that of the eggshell from which the powder is derived. A polymer composite composition comprising an eggshell component and a polymer component is also provided. | 2014-10-30 |
20140323617 | SUBSTRATE BINDING PROCESS - The invention relates to a process and composition for binding of a particulate or fibrous substrate, in particular natural particles or fibres such as for example wood particles and fibers, but also other natural fibers such as straw, flax, grass, straw, hemp, bagasse and bamboo. The current invention describes the composition of a cheap binder that can bind particles and fibers in a fast way, resulting in substrates that have the required mechanical properties. The binder has a good sustainability so that the end product also has an improved sustainability profile. Furthermore, the new binder composition will make the resulting substrates (composite materials) flame retardant. | 2014-10-30 |
20140323618 | CARBOHYDRATE POLYAMINE BINDERS AND MATERIALS MADE THEREWITH - A binder comprising the products of a carbohydrate reactant and polyamine is disclosed. The binder is useful for consolidating loosely assembled matter, such as fibers. Uncured fibrous products comprising fibers in contact with a carbohydrate reactant and a polyamine are also disclosed. The binder composition may be cured to yield a fibrous product comprising fibers bound by a cross-linked polymer. Further disclosed are methods for binding fibers with the carbohydrate reactant and polyamine based binder. | 2014-10-30 |
20140323619 | NON-AQUEOUS LIQUID CONCENTRATE FOR AQUEOUS DISPERSION - A non-aqueous liquid concentrate includes starch, an acrylic acid homopolymer salt, vegetable oil, and clay. The non-aqueous liquid concentrate forms an aqueous dispersion when added to water and is capable of clinging to a surface. | 2014-10-30 |
20140323620 | Solvent-Containing Clearcoat Coating Composition, Process For Preparation Thereof And Use Thereof - Described is a solvent-containing clearcoat coating composition comprising (A) an OH-functional (meth)acrylate (co)polymer component composed of (A1) at least one OH-functional (meth)acrylate (co)polymer having an OH number of 60-200 mg KOH/g and a glass transition temperature T | 2014-10-30 |
20140323621 | RESIN COMPOSITION AND SHAPED ARTICLE - A resin composition includes 100 parts by weight of a polyacetal copolymer, the amount of oxyalkylene units having 2 or more carbon atoms contained in the polyacetal copolymer is, per 100 mol of oxymethylene units of the polyacetal copolymer, 0.4 to 17.0 mol, relative to 100 parts by weight of the polyacetal copolymer, 0.01 to 1.0 part by weight of an amine-substituted triazine compound, 0.01 to 5.0 parts by weight of a hindered phenol, 0.001 to 3.0 parts by weight of a hindered amine, and 0.001 to less than 0.005 part by weight of at least one metal-containing compound selected from the group consisting of a hydroxide, an inorganic acid salt, and an alkoxide of an alkali metal or an alkaline earth metal. | 2014-10-30 |
20140323622 | Acetylated Derivatives of Castor Oil and Their Blends with Epoxidized Fatty Acid Esters - The present disclosure is directed to acetylated castor components and compositions including the same. The acetylated castor component may be an acetylated castor oil and/or an acetylated castor wax. The acetylated castor component may be blended with an epoxidized fatty acid ester. The present acetylated castor components and blends find advantageous application as a plasticizer. | 2014-10-30 |
20140323623 | RESIN COMPOSITION HAVING LIGHT GUIDING PROPERTIES, AND LIGHT-GUIDING MOLDED ARTICLE AND PLANAR LIGHT SOURCE MADE FROM SAME - A transparent resin composition having light guiding properties, alight guide molded article and a surface light source body. | 2014-10-30 |
20140323624 | PHOSPHAZENE COMPOUND HAVING VINYL GROUP, RESIN COMPOSITION CONTAINING THE SAME, AND CIRCUIT BOARD MANUFACTURED FROM THE SAME - A phosphazene compound having a vinyl group is manufactured by a reaction between a vinyl compound and a phosphazene compound having a hydroxyl group and added to a resin composition for manufacturing a prepreg or a resin film so as to be applicable to copper-clad laminates and printed circuit boards to thereby achieve satisfactory circuit laminate properties, namely low coefficient of thermal expansion, low dielectric properties, heat resistant, fire resistant, and halogen-free. | 2014-10-30 |
20140323625 | Flame Retardant Thermoplastic Resin Composition and Article Comprising the Same - The flame retardant thermoplastic resin composition includes about 100 parts by weight of a polycarbonate resin; about 5 parts by weight to about 30 parts by weight of a rubber modified aromatic vinyl-based copolymer resin; about 10 parts by weight to about 30 parts by weight of an aromatic phosphoric acid ester compound; and about 5 parts by weight to about 100 parts by weight of fillers including wollastonite and talc, wherein a weight ratio of wollastonite to talc ranges from about 1:about 0.1 to about 1:about 0.5. In the flame retardant thermoplastic resin composition, wollastonite and talc are present in a specific ratio, which can provide excellent properties in terms of stiffness such as flexural modulus and bending characteristics, and flame retardancy. | 2014-10-30 |
20140323626 | METHOD AND COMPOSITION FOR PREVENTING OXIDATION - A composition for inhibiting oxidation includes an anionic, hydrophilic, water soluble polymer, an anionic surfactant, and water. | 2014-10-30 |
20140323627 | RUBBER COMPOSITION AND TIRE USING THE SAME - In order to provide a rubber composition in which dispersibility of silica is improved and in which a viscosity of an unvulcanized rubber is lowered and a heat build-up improving effect of a vulcanized rubber is well exerted, and a tire prepared by using the rubber composition, the rubber composition is endowed with a constitution in which 100 parts by mass of at least one rubber component selected from natural rubber and/or diene base synthetic rubbers are compounded with 55 to 200 parts by mass of silica and 0.5 to 15 parts by mass of at least one of alkanolamines represented by the following Formula (I): | 2014-10-30 |
20140323628 | Stabilized polyamide compositions - The invention relates to a polyamide that is stabilized toward heat, light and/or bad weather by using a compound comprising at least one amine function and at least two aliphatic hydroxyl functions. The stabilizing compound may also be added to the polyamide to form stabilized polyamide compositions. | 2014-10-30 |