43rd week of 2010 patent applcation highlights part 48 |
Patent application number | Title | Published |
20100273942 | Method for Producing Water-Absorbing Polymer Particles - A process for producing water-absorbing polymer particles, comprising the addition of a solid additive to a polymer gel by means of a conveying screw ( | 2010-10-28 |
20100273943 | PEPTIDE CONJUGATES AND FLUORESCENCE DETECTION METHODS FOR INTRACELLULAR CASPASE ASSAY - Polypeptides labelled with a donor and acceptor pair of dyes selected from a dibenzorhodamine dye and a diamino-benzophenoxazine dye are peptide conjugates which are useful for intracellular and bead-based assays with fluorescence detection. Peptide conjugates with a caspase-recognition site undergo cleavage into peptide fragments which may be detected, located, and quantitated by the changes in fluorescence. Intracellular cleavage of peptide conjugates is correlated with apoptosis. | 2010-10-28 |
20100273944 | THERMOPLASTIC RESIN COMPOSITION, PRODUCTION METHOD THEREOF, AND MOLDED ARTICLE - A thermoplastic resin composition includes a thermoplastic resin (A) and a reactive functional group-containing resin (B), which has a specific structure in the morphology of the resin composition observed by transmission electron microscopy tomography, and the relaxation time T1C of each carbon nucleus by the solid NMR measurement of the thermoplastic resin composition containing a polyamide resin is kept in a specific range. The composition is excellent in the balance between contradictory properties such as impact resistance and heat resistance, remarkably exhibits a peculiar viscoelastic behavior not observed in the conventional polymeric materials, and is remarkably excellent in impact energy absorbing performance and vibration energy absorbing performance at the time of high-speed deformation. | 2010-10-28 |
20100273945 | THERMOPLASTIC VULCANISATE BLEND - The invention relates to a new polymer blend comprising:
| 2010-10-28 |
20100273946 | MICROCAPSULE, METHOD FOR MAKING THE SAME, AND COMPOSITE USING THE SAME - A carbon nanotube microcapsule includes at least one carbon nanotube and a shell encapsulating the at least one carbon nanotube. The shell includes a plurality of first functional groups. A composite using the carbon nanotube microcapsule, and a method for making the carbon nanotube microcapsule is also disclosed. | 2010-10-28 |
20100273947 | HOT-MELT ADHESIVE POLYESTER CONJUGATE FIBER - To obtain an ultrafine heat-shrinkable conjugate fiber at high productivity, in which a flow-drawing state of a polyester undrawn yarn is realized easily and stably. | 2010-10-28 |
20100273948 | FLUORINE-CONTAINING POLYMER POWDER, METHOD FOR PRODUCING THE SAME AND COATED ARTICLE - A stabilized fluorine-containing polymer powder having an average particle size of 5 to 100 μm is prepared by contacting a fluorine-containing polymer powder, which is prepared by milling the fluorine-containing polymer and removing fine particles, fibrous particles and coarse particles by classification, with a fluorinating agent so that the total number of unstable terminal groups is decreased to 7 to 50 per 10 | 2010-10-28 |
20100273949 | Star macromolecules for personal and home care - A polymer composition comprising star macromolecules is provided. Each star macromolecule has a core and five or more arms, wherein the number of arms within a star macromolecule varies across the composition of star molecules. The arms on a star are covalently attached to the core of the star; each arm comprises one or more (co)polymer segments; and at least one arm and/or at least one segment exhibits a different solubility from at least one other arm or one other segment, respectively, in a reference liquid of interest. | 2010-10-28 |
20100273950 | MICROWAVE HEATABLE MONOVINYL AROMATIC POLYMERS - A method for melt-processing a polymer of a monovinyl aromatic compound, such as styrene, is disclosed. The method may include heating a polymer of a monovinyl aromatic compound volumetrically with microwave energy, wherein the polymer of a monovinyl aromatic compound includes: a discontinuous rubber phase; and a continuous poly(monovinyl aromatic) phase comprising up to 49 weight percent of at least one of an acrylate comonomer and a vinyl cyanide comonomer. | 2010-10-28 |
20100273951 | ANTI-BLOCKING AGENT MASTER BATCH AND POLYOLEFIN-BASED RESIN FILM USING THE SAME - An anti-blocking agent master batch is provided, obtained by compounding 100 parts by mass of a polyolefin-based resin with 1 to 40 parts by mass of polymer fine particles, the polymer fine particles obtained by: causing two or more fluids including a liquid medium, a monomer or monomers, and a polymerization initiator to continuously and successively pass through a plurality of net bodies which are disposed at given intervals in a cylindrical passage and each have a surface crossing a direction of the passage to obtain an emulsion including liquid droplets containing the monomer or monomers and the polymerization initiator, the liquid droplets being dispersed in the liquid medium; and heating this emulsion to polymerize the monomer or monomers. Also provided is a manufacturing method thereof. The anti-blocking agent master batch can prevent the generation of die build-up during the manufacture of a master batch for a polyolefin-based resin film by compounding an anti-blocking agent into a polyolefin-based resin. | 2010-10-28 |
20100273952 | CONTROLLED POLYMERIZATION - The present invention discloses an emulsion polymerization process that comprises: (1) preparing an aqueous polymerization medium which is comprised of (a) at least one monomer, (b) a polymerization control agent, and an emulsifier, wherein the emulsifier is prepared in-situ within the aqueous polymerization medium; and (2) initiating polymerization of said monomer within the aqueous polymerization medium. The subject invention more specifically reveals an emulsion polymerization process that comprises: (1) preparing a monomer solution which is comprised of (a) at least one monomer, (b) a conjugate acid of a surfactant with a pK | 2010-10-28 |
20100273953 | FUNCTIONALIZED POLYARYL ETHERS - Branched polyaryl ether copolymers which are made up of the building blocks of the general formulae I and II | 2010-10-28 |
20100273954 | CROSS-LINKED PRODUCT OF METAL-CONTAINING POLYAMIC ACID, CROSS-LINKED PRODUCT OF METAL-CONTAINING POLYIMIDE INCLUDING THE CROSS-LINKED PRODUCT OF METAL-CONTAINING POLYAMIC ACID, METHOD OF MANUFACTURING THE CROSS-LINKED PRODUCT OF METAL-CONTAINING POLYIMIDE, AND POLYIMIDE FILM INCLUDING THE CROSS-LINKED PRODUCT OF METAL-CONTAINING POLYIMIDE - A cross-linked metal-containing polyamic acid includes a metal and a cross-linked polyamic acid which is a condensation product of an acid anhydride represented by Formula 1 and a diamine compound: | 2010-10-28 |
20100273955 | 6,6-Polyimide Copolymers and Processes for Preparing Them - The present invention provides a process for preparing a solvent-soluble polyimide copolymer synthesized from a 6,6-imide segment having an imide oligomer with PMDA at both ends produced by adding 4 molar equivalents of pyromellitic dianhydride (PMDA) and 2 molar equivalents of diaminotoluene (DAT) to an imide oligomer produced by heating 1 molar equivalent of biphenyltetracarboxylic dianhydride (BPDA) and 2 molar equivalents of diaminodiphenyl ether (DADE) at 160-200° C. in the presence of a catalyst in an organic polar solvent. | 2010-10-28 |
20100273956 | COPOLYESTERS HAVING IMPROVED THERMAL STABILITY AND METHODS FOR MAKING THEM - Processes for producing polyethylene terephthalate copolyesters are disclosed, that include the steps of:
| 2010-10-28 |
20100273957 | Prosthetic devices - A prosthetic device comprising at least one part consisting of a polymer composition comprising at least one polyarylene (P1) and at least one polyarylether selected from the group consisting of poly(aryl ether ketone)s (P2) and poly(aryl ether sulfone)s (P3). | 2010-10-28 |
20100273958 | ACRYLIC-BASED RUBBER MODIFIED THERMOSET COMPOSITION - The invention relates to a liquid rubber acrylic block copolymer, and its use in modifying a thermoset composition. The liquid rubber acrylic block copolymer adds toughness and flexibility to a thermoset composition. The acrylic block copolymers are especially useful for modifying epoxy compositions. | 2010-10-28 |
20100273959 | RESIN COMPOSITION AND MOLDED ARTICLE USING THE SAME - This invention provides a resin composition comprising a polyolefin-based polymer and an aliphatic polyester-based polymer, which has an excellent balance of impact resistance and rigidity and excellent properties, such as processability. The resin composition comprises a polyolefin-based polymer (A), an aliphatic polyester-based polymer (B), an elastomer (C), which has a melt flow rate (MFR), measured at 190° C. under a load of 21N, of 0.5 to 3.0 g/10 minutes, and an epoxy group-containing polyolefin-based polymer (D). | 2010-10-28 |
20100273960 | SLURRY PHASE POLYMERISATION PROCESS - Process for producing a multimodal polyethylene in at least two loop reactors connected in series, in which 20-80 wt % of a high molecular weight (HMW) polymer is made in suspension in a first reactor and 20-80 wt % of a low molecular weight (LMW) polymer is made in suspension in a second reactor, one polymer being made in the presence of the other in either order, wherein the ratio of the average activity in the LMW reactor to the average activity in the HMW reactor is from 0.25 and 1.5, where average activity in each reactor is defined as the rate of polyethylene produced in the reactor (kgPE/hr)/[ethylene concentration in the reactor (mol %)×residence time in the reactor (hours)×feed rate of catalyst into the reactor (g/hr)], residence time being defined as the mass of the polymer in the reactor (kg)/the output rate of polymer from the reactor (kg/hr), and the volumes of the two reactors differ by less than 10%. | 2010-10-28 |
20100273961 | Slurry Loop Reactors - Reactor systems suitable for the polymerization of an olefin monomer including first and second loop reactors effective for the polymerization of an olefin monomer and polymers formed therefrom are described herein. Each of said reactors generally include at least one settling leg connected to said reactor for receiving polymer slurry from said reactor and sequentially discharging settled polymer from said at least one settling leg to withdraw said polymer slurry from said reactor; a transfer line extending from the outlet at least one first reactor settling leg to an inlet for said second loop reactor; a flash line extending from said transfer line at a valve location intermediate said first reactor settling leg and said inlet for said second reactor; and a multiway valve located in said transfer line at said valve location intermediate said first reactor settling leg and the inlet to said second reactor and having one position in which said multiway valve provides for the flow of polymer slurry through said transfer line to said second reactor and another position in which said first reactor settling leg is connected to said flash line for the discharge of polymer slurry from said first reactor settling leg to said flash line and removal of said polymer from said polymer system. | 2010-10-28 |
20100273962 | Polyethylene Materials Prepared Using Mixed Ziegler-Natta Catalyst Systems - A polyethylene may be prepared using a mixture of a silica supported catalyst and a magnesium chloride supported catalyst. By changing the ratio of the two catalysts, the polyethylene produced may have a varying bulk density and shear response. The method allows for the tuning or targeting of properties to fit a specific application, such as a blow molding or vapor barrier film. | 2010-10-28 |
20100273963 | PROCESS FOR PRODUCING POLYDIENES - A process for preparing a polydiene, the process comprising the step of polymerizing conjugated diene monomer in the presence of a dihydrocarbyl ether, where said step of polymerizing employs a lanthanide-based catalyst system. | 2010-10-28 |
20100273964 | HETEROGENEOUS LEWIS ACID CATALYSTS FOR CATIONIC POLYMERIZATIONS - A process for cationically polymerizing olefin monomers in a reaction mixture includes the step of contacting olefin monomers and a catalytically effective amount of an initiating composition containing (A) a heterogeneous Lewis acid coinitiator selected from the group consisting of open chain and cyclic aluminoxane compounds and (B) an initiator selected from the group consisting of (i) organic compounds, (ii) halogens, (iii) interhalogens; (iv) Brönsted acids, (v) boron halides; and (vi) silicon compounds. A novel initiator system is further disclosed. | 2010-10-28 |
20100273965 | POLYMERIC ADDITIVES OBTAINED BY SALIFICATION OF COPOLYMERS - The present invention relates to a salified copolymer that can be obtained by salification, in an aqueous medium, using at least one amine containing at least one nitrogenous heterocyclic group, of a copolymer obtained from at least one cyclic anhydride-based or carboxylic acid-based monomer and from at least one styrene-based monomer, such as a styrene/maleic anhydride (SMA) copolymer. It also relates to the process for producing this salified copolymer, to a composition containing same, and also to the use of this composition for surface-treating, in particular coating, sizing and finishing, paper or cardboard. | 2010-10-28 |
20100273966 | Procatalyst Composition with Adamantane and Method - Disclosed are procatalyst compositions having an internal electron donor which includes an adamantanedicarboxylate and optionally an electron donor component. Ziegler-Natta catalyst compositions containing the present procatalyst compositions produce propylene-based olefins with broad molecular weight distribution. | 2010-10-28 |
20100273967 | FLUORINATED POLYMER, NEGATIVE PHOTOSENSITIVE RESIN COMPOSITION AND PARTITION WALLS - To provide a fluorinated polymer which enables to reduce the amount of residual ink on partition walls and to form an ink layer having high uniformity in film thickness, and a negative photosensitive composition. | 2010-10-28 |
20100273968 | Addition reaction to fluoroallylfluorosulfate - The invention pertains to a process for preparing compounds of formula (I-A) or (I-B) here below: by reaction of perfluoroallylfluorosulfate (FAFS) of formula (II): with at least one hypofluorite of formula (II-A) or (II-B): wherein: R | 2010-10-28 |
20100273969 | Support For Solid-Phase Synthesis and Process for Producing the Same - The present invention relates to a support for solid-phase synthesis, which contains a porous copolymer particle, the copolymer particle containing 25 to 60% by weight of an aromatic-vinyl structural unit, 20 to 55% by weight of a vinyl cyanide structural unit, 5 to 18% by weight of an ethylenically-unsaturated-carboxylic-acid structural unit, and 2 to 15% by weight of an aromatic-divinyl structural unit. The support according to the invention fluctuates little in the degree of swelling depending on the kind of the organic solvent in contact therewith. | 2010-10-28 |
20100273970 | PROCESS FOR PREPARATION OF HIGH PURITY METHACRYLIC ACID - The present invention relates to a process for preparation of pure methacrylic acid, at least comprising the process steps: a) gas phase oxidation of a C4 compound to obtain a methacrylic acid-comprising gas phase, b) condensation of the methacrylic acid-comprising gas phase to obtain an aqueous methacrylic acid solution, c) separation of at least a part of the methacrylic acid from the aqueous methacrylic acid solution to obtain at least one crude methacrylic acid-comprising product; d) separation of at least a part of the methacrylic acid from the at least one crude methacrylic acid-comprising product by means of a thermal separation process to obtain a pure methacrylic acid. | 2010-10-28 |
20100273971 | Reactor System and Process for the Catalytic Polymerization of Olefins, and the Use of Such Reactor System in Catalytic Polymerization of Olefins - The invention relates to a reactor system for the catalytic polymerization of olefin monomer and optionally comonomer(s), having one or more inlets for olefin monomer, catalyst, optionally for comonomer, chain growth controllers or chain transfer agents, and/or inert gas, an outlet for gas and an outlet for polymerized particles. The reactor system has at least one fluidized bed unit and at least one moving bed unit, wherein the fluidized bed unit has means for maintaining a fluidized bed in the fluidized bed unit and wherein the moving bed unit is provided with an inlet and an outlet which are directly connected to the fluidized bed unit, wherein the outlet of the moving bed unit is provided with means for pneumatically displacing polymer particles from the moving bed unit into the fluidized bed unit. | 2010-10-28 |
20100273972 | Method of Preparing a Silicone Resin - A method of preparing a silicone resin, the method comprising reacting at least one halodisilane and, optionally, at least one halosilane with at least one alcohol in the presence of an organic solvent to produce an alcoholysis product; reacting the alcoholysis product with water to produce a hydrolyzate; and heating the hydrolyzate to produce the resin. | 2010-10-28 |
20100273973 | CONTINUOUS PRODUCTION METHOD AND PRODUCTION APPARATUS OF AROMATIC POLYCARBONATE - The object of the present invention is to provide a method of producing plural kinds of aromatic polycarbonates by a melt process without changeover loss and quality deterioration. The present invention relates to a production method of an aromatic polycarbonate, comprising supplying a molten mixture of raw materials of an aromatic dihydroxy compound and/or a carbonic diester prepared in the absence of an ester exchange catalyst to polycondensation steps of two lines each equipped with three vertical reactors connected in series and one horizontal reactor, and at the same time, continuously conducting polycondensation reaction in the presence of an ester exchange catalyst. | 2010-10-28 |
20100273974 | POLYIMIDE RESIN COMPOSITION, POLYIMIDE PRECURSOR RESIN COMPOSITION FOR THE SAME, PRODUCTION METHOD THEREOF, AND POLYIMIDE FILM AND PRODUCTION METHOD THEREOF - An object of the present invention, which was made to solve the problems above, is to provide a polyimide precursor resin composition superior in transparency allowing reduction of the residual volatile material rate during molding and giving a polyimide resin composition (e.g., polyimide film) superior in mechanical properties and transparency even when a cheaper polyamide-imide is used. The present invention relates to a polyimide precursor resin composition, comprising a polyamide-imide (A) containing a diamine monomer unit represented by the following formula (1) and a polyamic acid (B) containing at least one kind of monomer unit selected tetracarboxylic acid monomer units represented by the following formulae (2p) to (2r), wherein the haze of the film having a thickness of 40 μm obtained by imidation of the polyimide precursor resin composition is 4% or less: | 2010-10-28 |
20100273975 | POLYOLS BASED ON MODIFIED AMINO RESINS, THEIR PREPARATION AND - Disclosed herein is a polyol (A) based on modified amino resins, prepared by reacting: an amino resin (B) comprising three acetalized or etherified N-methylol groups of the general formula (I)>N—CHR—OR | 2010-10-28 |
20100273976 | POLYIMIDE-BASED MATERIAL, COMPOSITION AND FILM, AND MANUFACTURING METHOD THEREOF - A polyimide-type material that exhibits an excellent heat resistance and moldability such as easiness of molding into a film configuration and low process load, and a film made from this polyimide-type material are provided. The polyimide-type material contains a polyamic acid and/or polyimide obtained by reacting (A) at least one acyl compound selected from the group consisting of 1-cis-2-cis-3-trans-4-trans-cyclopentanetetracarboxylic acid, 1-cis-2-cis-3-trans-4-trans-cyclopentanetetracarboxylic acid dianhydride, and reactive derivatives thereof, with (B) an imino-forming compound. | 2010-10-28 |
20100273977 | PROCESS FOR THE PREPARATION OF ECHINOCANDIN DERIVATIVES - A subject of the invention is a process for the preparation of the compounds of formula (I): | 2010-10-28 |
20100273978 | Modified polypeptides suitable for acceptace of amino acid substited molecules - The invention provides compositions and methods of identifying, modifying and producing modified target molecules, including therapeutic molecules by modification with non-natural amino acids. Certain aspects of the invention include methods of adding a chemical moiety to a target molecule, and the compositions resulting therefrom. Certain aspects of the invention also relate to kits for identifying, modifying and producing modified target molecules described herein. | 2010-10-28 |
20100273979 | COMPOSITIONS, METHODS AND USES - The present invention relates to a class of engineered polypeptides having a binding affinity for albumin. It also relates to new methods and uses that exploit binding by these and other compounds to albumin in different contexts, some of which have significance for the treatment of disease in mammals including humans. | 2010-10-28 |
20100273980 | FUNGAL PEPC INHIBITOR - The present invention relates to an isolated polypeptide having PepC inhibitory activity as well as to a method for producing a heterologous polypeptide of interest in an | 2010-10-28 |
20100273981 | Use of Silintaphin for the Structure-Directed Fabrication of (Nano)Composite Materials in Medicine and (Nano)Technology - The invention concerns the application of silintaphin-1 in the sustainable fabrication of hierarchically ordered silica structures from nano- to macro-scale at environmentally benign conditions and low energy costs (low temperature, low pressure, absence of caustic chemicals). | 2010-10-28 |
20100273982 | PROCESS FOR PRODUCTION OF BIVALIRUDIN - The invention relates to methods for the preparation of high purity Bivalirudin. The polypeptide is prepared in a high purity of at least 98.5% (by HPLC), wherein the total impurities amount to less than 1.5%, comprising not more than 0.5% [Asp | 2010-10-28 |
20100273983 | METHOD OF PURIFYING PEPTIDES BY SELECTIVE PRECIPITATION - A method is provided for purifying peptides by selective precipitation of contaminating proteins, such as host cell proteins and cleaved fusion partners. Also provided is a method of cleaving fusion proteins in cell lysates. | 2010-10-28 |
20100273984 | METHOD FOR ENRICHING PHOSPHOPEPTIDES - The invention relates to a method for enriching phosphopeptides. Said method is characterized in that a carrier is used which carries phosphate groups and/or phosphonate groups on the surface thereof. The phosphate groups and/or phosphonate groups are functionalized with zirconium ions and are bonded to the carrier by means of linker structures which have at least one alkyl chain containing at least 5 C atoms. Also disclosed are corresponding carriers and suitable kits for enriching phosphopeptides. | 2010-10-28 |
20100273985 | POST-TRANSLATIONAL MODIFICATIONS AND CLOSTRIDIAL NEUROTOXINS - The present invention discloses modified neurotoxins with altered biological persistence. In one embodiment, the modified neurotoxins are derived from Clostridial botulinum toxins. Such modified neurotoxins may be employed in treating various conditions, including but not limited to muscular disorders, hyperhidrosis, and pain. | 2010-10-28 |
20100273986 | POST-TRANSLATIONAL MODIFICATION AND CLOSTRIDIAL NEUROTOXINS - The present invention discloses modified neurotoxins with altered biological persistence. In one embodiment, the modified neurotoxins are derived from Clostridial botulinum toxins. Such modified neurotoxins may be employed in treating various conditions, including but not limited to muscular disorders, hyperhidrosis, and pain. | 2010-10-28 |
20100273987 | Soybean Cultivar 89146110 - A soybean cultivar designated 89146110 is disclosed. The invention relates to the seeds of soybean cultivar 89146110, to the plants of soybean 89146110, to plant parts of soybean cultivar 89146110 and to methods for producing a soybean plant produced by crossing soybean cultivar 89146110 with itself or with another soybean variety. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. This invention also relates to soybean cultivars or breeding cultivars and plant parts derived from soybean variety 89146110, to methods for producing other soybean cultivars, lines or plant parts derived from soybean cultivar 89146110 and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants and plant parts produced by crossing the cultivar 89146110 with another soybean cultivar. | 2010-10-28 |
20100273988 | ANTI-CANCER AGENT COMPRISING ANTI-HB-EGF ANTIBODY AS ACTIVE INGREDIENT - A monoclonal antibody having a neutralizing activity on HB-EGF is disclosed. The monoclonal antibody of the present invention is preferably an antibody that does not bind to the HB-EGF protein on the cell surface of HB-EGF-expressing cells. Also provided are an anti-cancer agent and a cell proliferation inhibitor, which comprise the monoclonal antibody of the present invention as an active ingredient, and a method of treating cancer, the method comprising administering the monoclonal antibody of the present invention. Cancers that can be treated by the anti-cancer agent of the present invention include pancreatic cancer, liver cancer, esophageal cancer, melanoma, colorectal cancer, gastric cancer, ovarian cancer, bladder cancer, and brain tumors. | 2010-10-28 |
20100273989 | ANGIOTENSIN CONVERTING ENZYME HOMOLOG AND USES THEREFOR - The present invention relates to the discovery of novel genes encoding an angiotensin converting enzyme, Angiotensin Converting Enzyme-2 (ACE-2). The invention provides therapeutics, prognostic and diagnostic methods for treating blood pressure related disorders as well as various types of allergic conditions, among others. Also disclosed are screening assays for identifying compounds for treating and preventing these conditions. | 2010-10-28 |
20100273990 | Notch-based fusion proteins and uses thereof - This invention provides a method for treating a subject having a tumor and a method for inhibiting angiogenesis in a subject, both comprising administering to the subject an effective amount of a composition of matter comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety. This invention also provides a composition of matter comprising the extracellular domain of Notch4 receptor protein operably affixed to a half-life-increasing moiety. This invention further provides an article of manufacture. Finally, this invention provides a replicable vector which encodes a polypeptide comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety, a host vector system which comprises such replicable vector and a method of producing such polypeptide. | 2010-10-28 |
20100273991 | METHOD OF COVALENTLY MODIFYING PROTEINS WITH ORGANIC MOLECULES TO PREVENT AGGREGATION - A system and method for preventing protein aggregation is developed by covalent modification of proteins with organic molecules that can preserve the native protein folding. Proteins are covalently modified with sugar alcohols or cyclodextrins (organic Kosmotropes) or other small molecule drugs by water-driven bioorganic reactions in water. In the water-driven bioorganic reactions, the reagent is stable in water and can modify lysine residues or cysteine residue of a protein at physiological conditions with high yield and fast rate. Proteins and antibodies will be modified by non-natural sugar alcohols. As a result, the efficacy of protein drugs (reduction in aggregation and enzymatic degradation, and increase in blood stream life time) may be improved. | 2010-10-28 |
20100273992 | METHOD FOR THE PRODUCTION OF AN IMMUNOSTIMULATING MUCIN (MUC1) - The present invention relates to a method for producing or identifying a MUC1 molecule which is able to generate an immune response in humans. The invention also relates to a method for producing or identifying a cell, cell lines or cell lysates containing a MUC1 molecule that is able to generate an immune response in humans. The invention further relates to methods for producing medicaments and diagnostic agents. Also disclosed is the use of the MUC1 molecules, cells or cell lysates obtained by means of the methods according to the invention for producing a medicament used for treating or preventing tumours. Further disclosed is a purified MUC1 molecule that can be obtained by means of the methods according to the invention and has an immunostimulating effect on humans. The invention additionally relates to the use of a MUC1 antibody for the production of a medicament used for treating or preventing tumours. | 2010-10-28 |
20100273993 | METHOD FOR THE EXTRACTION OF MEMBRANE PROTEINS - The present invention relates to the use of linear, amphipathic carbohydrate polymers for the extraction of membrane proteins from biological samples, to a method for the extraction of membrane proteins, to a kit for the extraction of these proteins, and to the use thereof. | 2010-10-28 |
20100273994 | HYBRID COMPOUNDS CONTAINING POLYSACCHARIDE(S) AND AT LEAST ONE POLYOXYALKYLENE, METHOD FOR PREPARING SAME, AND APPLICATIONS THEREOF - The invention relates to novel hybrid compounds containing at least one polysaccharide entity (PS), such as guar, in which at least one hydroxyl function is substituted by at least one A polyoxyalkylene entity (PEG). The swivel Ro between the entity PS and the entity A is obtained by click chemistry and has the following formula (II.1) or (II.2), in which Z is a carbon or nitrogen atom. These hybrid compounds can be used as emulsifiers, particularly in cosmetics. | 2010-10-28 |
20100273995 | Polynucleotides and their use for detecting resistance to streptogramin a or to streptogramin B and related compounds - The present invention pertains to polynucleotides derived from staphylococcal genes encoding resistance to streptogramin A or to streptogramin B and chemically related compounds. This invention also relates to the use of the polynucleotides as oligonucleotide primers or probes for detecting Staphylococcal strains that are resistant to streptogramin A or to streptogramin B and related compounds in a biological sample. In another embodiment, the present invention is directed to the full length coding sequences of the staphylococcal genes encoding for resistance to streptogramin A or to streptogramin B from | 2010-10-28 |
20100273996 | Method - A method of producing a replication defective retrovirus comprising transfecting a producer cell with the following: iii) a retroviral genome; iv) a nucleotide sequence coding for retroviral gag and pot proteins; and iii) nucleotide sequences encoding other essential viral packaging components not encoded by the nucleotide sequence of (ii); characterised in that the nucleotide sequence coding for retroviral gag and pot proteins is codon optimised for expression in the producer cell. | 2010-10-28 |
20100273997 | Ribozyme to cleave coronavirus gene - Provided is a ribozyme to cleave a coronavirus gene and a therapeutic agent for a coronavirus infectious disease. A common base sequence in coronaviruses such as SARS-CoV and MHV was searched to design a ribozyme including a base sequence complementary thereto. Moreover, a therapeutic agent for a coronavirus infectious disease including such ribozyme was obtained. | 2010-10-28 |
20100273998 | METHODS AND COMPOSITIONS FOR MODULATING TISSUE FACTOR - The present invention features nucleic acid molecules, specifically short interfering RNA molecules, that are able to modulate the expression of TF and methods for using such molecules for the treatment of coagulative disorders and for the prevention and treatment of cancer. | 2010-10-28 |
20100273999 | Preparation of Nucleotide Oligomer - The present invention provides a method for preparing nucleotide oligomers, including (a) coupling a nucleotide dimer or nucleotide trimer to a nucleoside attached to solid supports or to universal solid supports as a starting material; (b) sequentially coupling nucleotide monomers to the resulting structures of Step (a) to prepare a nucleotide oligomer; and (c) removing the nucleotide oligomers from the solid supports. | 2010-10-28 |
20100274000 | LIGHT-RESPONSIVE ARTIFICIAL NUCLEOTIDE HAVING PHOTO-CROSSLINKING ABILITY - The present invention provides a photoreactive crosslinking agent that is capable of crosslinking a sequence which cannot be photo-crosslinked by psoralen, and is capable of photo-crosslinking using a light having a longer wavelength, as compared with psoralen. The present invention also provides a compound having a group represented by formula (I) coupled with a group represented by formula (II). | 2010-10-28 |
20100274001 | METHOD FOR PRODUCING CELLULOSE ETHER DERIVATIVE - The present invention relates to a process for producing a cellulose ether derivative in an industrially convenient and efficient manner by reacting a low-crystalline powdery cellulose with an epoxy compound in the presence of a catalyst. | 2010-10-28 |
20100274002 | CYCLODEXTRIN-SILANE COMPLEXES - Complexes of silanes and cyclodextrin or derivatives thereof are storage stable and allow target release of silane or decomposition products thereof. | 2010-10-28 |
20100274003 | ACID ADDITION SALTS OF SYNTHETIC INTERMEDIATES FOR CARBAPENEM ANTIBIOTICS AND PROCESSES FOR PREPARING THE SAME - The present invention provides a process for preparing an acid addition salt of a synthetic intermediate for carbapenem antibiotics and a novel acid addition salt of a synthetic intermediate for carbapenem antibiotics obtained from the process. The present invention also provides a process for preparing a carbapenem antibiotic using the acid addition salt. According to the process of the present invention, an acid addition salt of a synthetic intermediate for carbapenem antibiotics can be prepared in a high yield and high purity, without conducting column chromatography. Thus, the process of the present invention can be applied to mass production with an industrial scale. Furthermore, since the acid addition salts have solid forms, they are easy to handle and keep in a manufacturing site. | 2010-10-28 |
20100274004 | BICYCLIC PIRAZOLE COMPOUNDS AS ANTIBACTERIAL AGENTS - Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection. | 2010-10-28 |
20100274005 | BICYCLIC PYRAZOLE COMPOUNDS AS ANTIBACTERIAL AGENTS - Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection. | 2010-10-28 |
20100274006 | Clathrate compound, method for controlling concentration of aqueous agricultural chemical active ingredient solution, and agricultural chemical formulation - A clathrate compound containing a polymolecular host compound as a host compound and an agricultural chemical active ingredient having a saturated solubility in water at 25° C. of not less than 500 ppm as a guest compound. | 2010-10-28 |
20100274007 | PROCESS FOR PREPARING POLYMORPHIC FORMS OF (S)-6-CHLORO-(CYCLOPROPYLETHYNYL)-1,4-DIHYDRO-4-(TRIFLUOROMETHYL)-2H-3,1-- BENZOXAZIN-2-ONE - Disclosed herein is a novel process for preparing polymorphic Forms of (S)-6-chloro-(cyclopropylethynyl)-1,4-di-hydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one referred as M | 2010-10-28 |
20100274008 | METHOD FOR THE PRODUCTION OF AN AMINE - Processes for preparing an amine, the processes comprising: reacting a reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones, and mixtures thereof, with hydrogen and a nitrogen compound selected from the group consisting of ammonia, primary amines, secondary amines and mixtures thereof, in the presence of a zirconium dioxide-, copper- and nickel-containing catalyst; wherein the catalyst comprises a catalytically active composition which comprises, before reduction with hydrogen, oxygen compounds of zirconium, copper, and nickel, and 1.0 to 5.0% by weight of an oxygen compound of cobalt, calculated as CoO, and 0.2 to 5.0% by weight of a polyoxometalate. | 2010-10-28 |
20100274009 | METHOD FOR PRODUCING AN AMINE - Processes for preparing an amine, the processes comprising: reacting a reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones, and mixtures thereof, with hydrogen and a nitrogen compound selected from the group consisting of ammonia, primary amines, secondary amines and mixtures thereof, in the presence of a zirconium dioxide-, copper- and nickel-containing catalyst; wherein the catalyst comprises a catalytically active composition which comprises, before reduction with hydrogen, oxygen compounds of zirconium, copper, nickel, no oxygen compounds of cobalt, and 0.2 to 5.0% by weight of at least one oxygen compound of phosphorus or gallium, calculated as H | 2010-10-28 |
20100274010 | METHOD FOR PRODUCING AN AMINE - Processes for preparing an amine, which processes comprise: reacting a reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones, and mixtures thereof, with hydrogen and a nitrogen compound selected from the group consisting of ammonia, primary amines, secondary amines and mixtures thereof, in the presence of a zirconium dioxide-, copper- and nickel-containing catalyst; wherein the catalyst comprises a catalytically active composition which comprises, before reduction with hydrogen, oxygen compounds of zirconium, copper, and nickel, and 0.2 to 40% by weight of an oxygen compound of cobalt, calculated as CoO, 0.1 to 5% by weight of an oxygen compound of iron, calculated as Fe | 2010-10-28 |
20100274011 | METHOD FOR THE PRODUCTION OF AN AMINE - Processes for preparing an amine, the processes comprising: reacting a reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones, and mixtures thereof, with hydrogen and a nitrogen compound selected from the group consisting of ammonia, primary amines, secondary amines and mixtures thereof, in the presence of a zirconium dioxide-, copper- and nickel-containing catalyst; wherein the catalyst comprises a catalytically active composition which comprises, before reduction with hydrogen, oxygen compounds of zirconium, copper, and nickel, 1.5 to 4.5% by weight of an oxygen compound of cobalt, calculated as CoO, and 0.2 to 5.0% by weight of at least one oxygen compound of niobium, sulfur, phosphorus, gallium, boron, lead or antimony, calculated in each case as Nb | 2010-10-28 |
20100274012 | Photochemical Crosslinkers for Polymer Coatings and Substrate Tie-Layer - The invention describes novel crosslinking compounds that include photoactivatable moieties. Several families of compounds are disclosed that can include one or more hydrophilic moieties that help to solubilize the compounds in aqueous environments. | 2010-10-28 |
20100274013 | DIPEPTIDYL PEPTIDASE-IV INHIBITING COMPOUNDS, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS ACTIVE AGENT - Disclosed herein are novel compounds of Formula (1) as defined in the specification having excellent inhibitory activity against dipeptidyl peptidase-IV (DPP-IV), methods of preparing the same and pharmaceutical compositions comprising the same as an active agent. | 2010-10-28 |
20100274014 | PROCESS FOR MANUFACTURING ROSUVASTATIN POTASSIUM AND CRYSTALLINE AND AMORPHOUS FORMS THEREOF - A process of manufacturing of Rosuvastatin Potassium of formula (I) | 2010-10-28 |
20100274015 | SYNTHESIS OF 4/5-PYRIMIDINYLIMIDAZOLES VIA SEQUENTIAL FUNCTIONALIZATION OF 2,4-DICHLOROPYRIMIDINE - This invention relates to methods of making pyrimidinyl-substituted imidazole compounds by sequential substitution of the 4- and 2-chloro groups of 2,4-dichloropyrimidine, nucleophilic substitution to form pyrimidinylalkyne derivatives, oxidation to the corresponding 1,2-diketones, and cyclocondensation reactions. | 2010-10-28 |
20100274016 | SYNTHESIS OF 4/5-PYRIMIDINYLIMIDAZOLES VIA SEQUENTIAL FUNCTIONALIZATION OF 2,4-DICHLOROPYRIMIDINE - This invention relates to methods of making pyrimidinyl-substituted imidazole compounds by sequential substitution of the 4- and 2-chloro groups of 2,4-dichloropyrimidine, nucleophilic substitution to form pyrimidinylalkyne derivatives, oxidation to the corresponding 1,2-diketones, and cyclocondensation reactions. | 2010-10-28 |
20100274017 | PROCESSES FOR THE PREPARATION OF SITAGLIPTIN AND PHARMACEUTICLLY ACCEPTABLE SALTS THEREOF - There is provided salts and polymorphs of sitagliptin, processes for the preparation thereof, and pharmaceutical compositions comprising the same. | 2010-10-28 |
20100274018 | PROCESS FOR THE RESOLUTION OF ZOPICLONE AND INTERMEDIATE COMPOUNDS - The present invention refers to a process for the resolution into one of its enantiomers of the racemate of compound of formula (I): | 2010-10-28 |
20100274019 | PROCESS FOR PREPARING OXYMORPHONE, NALTREXONE, AND BUPRENORPHINE - Methods are provided which include converting oripavine to other opiates, including converting oripavine to naltrexone, buprenorphine, 14-hydroxymorphinone and/or converting 14-hydroxymorphinone to oxymorphone. Purification and salt formation are optionally included. | 2010-10-28 |
20100274020 | PROCESS FOR THE PREPARATION OF PHARMACEUTICAL INTERMEDIATES - The invention relates to a process for the preparation of cyclopropyl benzyl ketone compounds of formula (II) wherein R | 2010-10-28 |
20100274021 | METHOD FOR PRODUCING 2,2-DIFLUOROETHYLAMINE DERIVATIVES BY IMINE HYDROGENATION - Process for preparing 2,2-difluoroethylamine derivatives, wherein compounds of the general formula (IV) are hydrogenated to the corresponding 2,2-difluoroethylamine derivatives of the general formula (III), where the A radical is as defined in the description: | 2010-10-28 |
20100274022 | G PROTEIN-COUPLED RECEPTOR INHIBITOR AND PHARMACEUTICAL PRODUCT - Disclosed are a substance and a pharmaceutical product inhibiting activation of a G protein-coupled receptor. Specifically disclosed is a G protein-coupled receptor inhibitor containing a specific compound represented by the following formula (1): | 2010-10-28 |
20100274023 | NOVEL INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF MESO-SUBSTITUTED CYANINE, MEROCYANINE AND OXONOLE DYES - The present invention provides new intermediate compounds enabling the preparation of N-meso substituted cyanine, merocyanine or oxonole dyes wherein the N-meso substituent comprises electron withdrawing groups and wherein such N-meso substituents are introduced at the intermediate level. These intermediates enable the formation of dyes having in the meso-position N-substituents comprising electron withdrawing groups without the need for further derivatization of the meso-substituent at the dye level. | 2010-10-28 |
20100274024 | A Compound Absorbing Sunlight And Converting The Sunlight Into Electrical Energy, And Method For Manufacturing The Same - A compound for absorbing sunlight and converting the sunlight into electrical energy, which is formed by coupling a fullerene with at least one or more triarylamine derivatives. The fullerene is selected from among those having carbon numbers C | 2010-10-28 |
20100274025 | METHODS AND COMPOUNDS FOR PRODUCING DIPEPTIDYL PEPTIDASE IV INHIBITORS AND INTERMEDIATES THEREOF - Methods and compounds for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided. | 2010-10-28 |
20100274026 | Virus therapeutic drug - The object of the present invention is to provide a pharmaceutical composition for preventing or treating viral infectious diseases. The compounds of the present invention have extremely potent anti-HCV activity and HCV growth inhibitory effects, and since they also only demonstrate mild cytotoxicity in vivo, a pharmaceutical composition containing the compound of the present invention is extremely useful as an anti-HCV preventive/therapeutic agent. | 2010-10-28 |
20100274027 | ORGANIC COMPOUNDS - The invention provides a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Allskiren. Inter alia, the invention provides a process for the manufacture of a compound of the formula III, | 2010-10-28 |
20100274028 | REMOVAL OF POLAR ORGANIC COMPOUNDS AND EXTRANEOUS METALS FROM ORGANOSILANES - The invention relates to a process for treating a composition comprising organosilanes and at least one polar organic compound and/or at least one extraneous metal and/or a compound containing extraneous metal, wherein the composition is contacted with at least one adsorbent and a composition in which the content of the organic polar compound and/or of the extraneous metal and/or of the compound containing extraneous metal is reduced is subsequently obtained, and also to a corresponding composition in which the content of polar organic compounds and/or extraneous metals has been reduced to traces, and to the use of organic resins, activated carbons, silicates and/or zeolites for reducing the amounts of the compounds mentioned. | 2010-10-28 |
20100274029 | METHOD OF PREPARING (6R)-3-HEXYL-4-HYDROXY-6-UNDECYL-5, 6-DIHYDROPYRAN-2-ONE, AND INTERMEDIATE USED IN THE METHOD - Provided is a method of preparing a (6R)-3-hexyl-4-hydroxy-6-undecyl-5,6-dihydropyran-2-one, and a (5R)-2-hexyl-5-hydroxy-3-iminohexadecanoate derivative used in said method as an intermediate. | 2010-10-28 |
20100274030 | CYCLIC ETHERS - A process of preparing cyclic ethers is described. The process involves the reaction of at least one organic compound such as a dioi or a polyol which it has at least one pair of hydroxyl groups separated by 4 or 5 carbon atoms, and which is capable of being converted into an ether linkage, with an organic carbonate in the presence of a base. The base is an alkoxy, a carbonate or a hydroxide base or is a mixture of such bases. At least one of the hydroxyl groups of the organic compound is not a tertiary hydroxyl group. | 2010-10-28 |
20100274031 | METHODS FOR THE SYNTHESIS OF AMRUBICIN - Methods for producing amrubicin and structural analogs thereof. The present invention encompasses synthetic pathways for the production of amrubicin (Formula I) and structural analogs thereof. The synthetic pathways of the present invention preferably employ as a starting material an anthracycline compound having the generic Formula II: | 2010-10-28 |
20100274032 | METHOD FOR PREPARING PROSTAGLANDIN DERIVATIVE - Disclosed is a method for preparing a prostaglandin derivative of formula (A): | 2010-10-28 |
20100274033 | PRODUCTION OF FATTY ACID ESTERS - Methods of producing fatty acid esters, such as fatty acid ethyl esters, from genetically engineered microorganisms are described. | 2010-10-28 |
20100274034 | METHOD AND APPARATUS FOR PRODUCING FATTY ACID ALKYL ESTER AND/OR GLYCERIN - The present invention provides a method of producing a fatty acid alkyl ester and/or glycerin by bringing an oil and an alcohol into contact with each other, the method including: reacting the oil and alcohol with each other; performing solid-liquid separation for removing a solid sterol from a reaction liquid obtained in the step of reacting; and performing phase separation for separating the reaction liquid into a hydrophobic phase and a hydrophilic phase after the reaction liquid is subjected to the step of performing the solid-liquid separation, the hydrophobic phase containing the fatty acid alkyl ester, and the hydrophilic phase containing glycerin. Thereby, the present invention provides a method allowing stable continuous operation for a long time period for production of a fatty acid alkyl ester and/or glycerin. | 2010-10-28 |
20100274035 | Process for Recycling Cyclopentadienyl Derivatives and Preparing Metallocenes From Recycled, Substituted Cyclopentadienyl Derivatives - The present invention relates to a process for recycling cyclopentadienyl derivatives of the formulae (I) and (I′), a process for preparing metallocenes of the formula (III) from cyclopentadienyl derivatives of the formulae (I) and (I′) or from bridged biscyclopentadienyl derivatives of the formula (II), in which the cyclopentadienyl derivatives of the formulae (I), (I′) or (II) which are used have been at least partly recovered and purified by means of liquid-solid chromatography, and the use of liquid-solid chromatography for purifying substituted, recovered cyclopentadienyl derivatives of the formulae (I), (I′) or (II). | 2010-10-28 |
20100274036 | ORGANIC/INORGANIC COMPOSITIVE DISPERSANT INCLUDING INORGANIC CLAY AND ORGANIC SURFACTANT - The present invention provides an organic/inorganic compositive dispersant and a method for producing the same. The compositive dispersant comprises a complex of inorganic clay and an organic surfactant. The compositive dispersant is produced by reacting inorganic clay with the organic surfactant in a solvent to generate a complex. The inorganic clay is layered or platelet. The organic surfactant is an anionic surfactant such as alkyl sulfates, a nonionic surfactant such as octylphenol polyethoxylate and polyoxyethylene alkyl ether, or a cationic surfactant such as fatty (C12˜C32) quaternary ammonium salts and fatty (C12˜C32) quaternary ammonium chlorides. | 2010-10-28 |
20100274037 | ALLYLIC POLYSULFANES - Diallylic polysulfides (polysulfanes) are provided with sulfur chain lengths of 9 to 22. Also provided are bis(2-methyl-2-propenyl) polysulfides with sulfur chain lengths of 3 to 22. Also provided are 2-substituted bis(2-propenyl) polysulfides with sulfur chain lengths of 3 to 20. Also provided are the 2-cycloalken-1-yl polysulfides, 2-cyclohexen-1-yl polysulfides and 2-cyclopenten-1-yl polysulfides, with sulfur chain lengths of 3 to 20. Also provided are processes for extending the sulfur chain length of diallylic polysulfides and 2-substituted analogues thereof and allyl methyl polysulfides by bringing such compounds into contact with elemental sulfur and heating, or by mixing with molten sulfur. | 2010-10-28 |
20100274038 | METHOD FOR SYNTHESIS OF ACROLEIN FROM GLYCEROL - The invention provides a technology for producing acrolein from glycerol while maintaining high reagent partial pressures, which leads to higher yield. The invention more particularly relates to a method for producing acrolein from glycerol that comprises the intermediate step of forming glycerol and acrolein cyclic acetals. | 2010-10-28 |
20100274039 | CATALYST COMPOSITION INCLUDING ZIRCONIUM COMPOUNDS FOR ESTERFICATION REACTION AND METHOD FOR PREPARING ESTER COMPOUNDS - The present invention relates to an esterification catalyst composition that includes a zirconium compound and a method for producing an ester compound, which includes the steps of esterifying alcohol and carboxylic acid compounds by using the same, and it may be applied to a mass synthesis process. | 2010-10-28 |
20100274040 | 1,1'-Bi-2-Naphthol Derivatives Having (Meth)acrylate Groups - The present invention relates to 1,1′-bi-2-naphthol derivatives having (meth)acrylate groups, which can be used for preparing photocurable coating and has a refractive index of 1.53 or more. By using the present 1,1′-bi-2-naphthol derivatives, optical components with high refractive index and less light dispersion can be produced. | 2010-10-28 |
20100274041 | METHOD FOR PREPARING A CARBAMATE, A CATALYST APPLIED IN THE METHOD, A METHOD FOR PREPARING THE CATALYST AND USE THEREOF - The present invention pertains to a novel method for preparing a carbamate, in which the method comprises reacting an aliphatic substituted urea and/or its derivatives, with a hydroxyl group containing compound to obtain a carbamate. In addition, the present invention provides a novel catalyst which is suitable for catalyzing the reaction to form a carbamate, and a method for preparing the novel catalyst. The method of the present invention for preparing a carbamate does not involve the application of carbon monoxide which is toxic, and the reaction conditions are relatively mild with high catalytic activity, high reaction selectivity of the catalyst, and a relatively short reaction time. Furthermore, the catalyst is separated from the reaction system and reused easily, which will facilitates scale up and industrial application. | 2010-10-28 |